Job Description Q4JIM5 Confidence 100.00% Date Tue Jul 30 13:05:37 BST 2013 Rank 4 Aligned Residues 434 % Identity 44% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å Model Dimensions (Å) X:67.683 Y:76.827 Z:48.690

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		111	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150			.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.
Predicted Secondary structure																																										.	.
Query SS confidence																																										.	.
Query Sequence		L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	Q	N	G	E	W	S	E	V	R	S	.	.	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N	S	L
Query Conservation																																										.	.
Alig confidence																																.										.	.
Template Conservation																																.
Template Sequence		T	F	V	A	L	Y	D	Y	E	S	R	T	E	T	D	L	S	F	K	K	G	E	R	L	Q	I	V	N	N	T	.	E	G	D	W	W	L	A	H	S	L	S	T	G	Q	T	G	Y	I	P	S	N	Y	V	A	P	S	D	S	I
Template Known Secondary structure						S	S		B				S	S	S	B			B		T	T									S	.	S	S	S							T	T	T								G	G	G				T	T	S	G
Template Predicted Secondary structure																																.
Template SS confidence
		85	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.		.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.
		169	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190			.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.						.	.	.	.	.	.	220	.
Predicted Secondary structure																								.	.																								.	.	.	.	.
Query SS confidence																								.	.																								.	.	.	.	.
Query Sequence		E	K	H	S	W	Y	H	G	P	V	S	R	S	A	A	E	Y	L	L	S	S	L	.	.	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	L	S	I	S	L	R	Y	.	.	.	.	.	E	G	R	V	Y	H	Y	R
Query Conservation																								.	.																								.	.	.	.	.
Alig confidence																								.	.																								.	.	.	.	.
Template Conservation
Template Sequence		Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E	R	L	L	L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	K	G	A	Y	C	L	S	V	S	D	F	D	N	A	K	G	L	N	V	K	H	Y	K
Template Known Secondary structure		G	G	S	T	T	B			S											T		T	T			T	T								S	S	S	T	T											T	T	T
Template Predicted Secondary structure
Template SS confidence
		144	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.
		222	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	N	T	T	T	D	S	K	V	Y	V	T	A	E	S	R	F	S	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	V	T	T	L	H	Y	P	A	P	K	C	N	K	P	T	V	Y	G	V	S	P	I	H	D	K	W
Query Conservation
Alig confidence																																																					.	.	.
Template Conservation																																																					.	.	.
Template Sequence		I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S	L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H	R	L	T	T	V	C	P	T	S	K	P	Q	T	Q	G	.	.	.	L	A	K	D	A	W
Template Known Secondary structure			B		.			S						T	T				S	S													T	T	S	S	S														S	S	.	.	.	S	S	T	T		S
Template Predicted Secondary structure																																																					.	.	.
Template SS confidence
		204	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.				.	.	.	.	.	260
		282	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	V	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	F	K	E	D	T	M	E	V	E	E	F	L	K	E	A	A	V	M	K	E	I	K	H
Query Conservation
Alig confidence																														.
Template Conservation																														.
Template Sequence		E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M	G	T	W	N	G	.	T	T	R	V	A	I	K	T	L	K	P	G	T	M	S	P	E	A	F	L	Q	E	A	Q	V	M	K	K	L	R	H
Template Known Secondary structure		B			G	G	G											S	S									T	T	.	T										T	T	S	S
Template Predicted Secondary structure																														.
Template SS confidence
		261	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.		.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.
		342	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	N	L	V	Q	L	L	G	V	C	T	L	E	P	P	F	Y	I	V	T	E	Y	M	P	Y	G	N	L	L	D	Y	L	R	E	C	S	R	E	E	V	T	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E
Query Conservation
Alig confidence													.
Template Conservation													.
Template Sequence		E	K	L	V	Q	L	Y	A	V	V	S	.	E	E	P	I	Y	I	V	T	E	Y	M	S	K	G	S	L	L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E
Template Known Secondary structure		T	T	B									.	S	S	S									T	T								S					T	T
Template Predicted Secondary structure													.
Template SS confidence
		320	.	.	.	.	.	.	.	.	.	330		.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.
		402	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	K	N	F	I	H	R	D	L	A	A	R	N	C	L	V	G	E	N	H	V	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L	V	G	E	N	L	V	C	K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I	K	W	T	A	P	E	A	A	L	Y	G	R
Template Known Secondary structure			T	T				S			S	G	G	G					G	G	G							T	T	S	T	T	T								T	T		S	T	T	S		G	G	G	S
Template Predicted Secondary structure
Template SS confidence
		379	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.
		462	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y	D	L	L	E	K	G	Y	R	M	E	Q	P	E	G	C	P	P	K	V	Y	E	L	M	R	A	C
Query Conservation
Alig confidence
Template Conservation
Template Sequence		F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K	G	R	V	P	Y	P	G	M	V	N	R	E	V	L	D	Q	V	E	R	G	Y	R	M	P	C	P	P	E	C	P	E	S	L	H	D	L	M	C	Q	C
Template Known Secondary structure																			T	T	T	T			S	S	T	T												T	T							T	T
Template Predicted Secondary structure
Template SS confidence
		439	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.
		522	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550
Predicted Secondary structure
Query SS confidence
Query Sequence		W	K	W	S	P	A	D	R	P	S	F	A	E	T	H	Q	A	F	E	T	M	F	H	D	S	S	I	S	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		W	R	K	E	P	E	E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y	F	T	S	T	E	P	Q	Q
Template Known Secondary structure		T		S	S	G	G	G	S												T	S	S				S
Template Predicted Secondary structure
Template SS confidence
		499	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.