Job Description P26450 Confidence 100.00% Date Tue Jul 30 13:13:01 BST 2013 Rank 8 Aligned Residues 213 % Identity 31% Template c1a81E_ PDB info PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam Resolution 3.00 Å Model Dimensions (Å) X:45.000 Y:63.771 Z:37.235

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		327	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.			.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.
Predicted Secondary structure																							.	.																																					.
Query SS confidence																							.	.																																					.
Query Sequence		S	L	Q	D	A	E	W	Y	W	G	D	I	S	R	E	E	V	N	E	K	L	.	.	R	D	T	A	D	G	T	F	L	V	R	D	A	S	T	K	M	H	G	D	Y	T	L	T	L	R	K	G	G	N	N	K	L	I	K	I	.
Query Conservation																							.	.																																					.
Alig confidence																							.	.																	.																				.
Template Conservation																																									.
Template Sequence		S	A	N	H	L	P	F	F	F	G	N	I	T	R	E	E	A	E	D	Y	L	V	Q	G	G	M	S	D	G	L	Y	L	L	R	Q	S	R	N	Y	.	L	G	G	F	A	L	S	V	A	H	G	R	K	A	H	H	Y	T	I	E
Template Known Secondary structure			G	G	G		T	T			S	S												T	T	T			T	T								S	S	S	.	T	T									S	S	S
Template Predicted Secondary structure																																									.
Template SS confidence
		9	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.		.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.
		384	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	H	R	D	G	K	Y	G	F	S	D	P	L	T	F	N	S	V	V	E	L	I	N	H	Y	R	N	E	S	L	A	Q	Y	N	P	K	L	D	V	K	L	L	Y	P	V	S	K	Y	Q	Q	D	Q	V	V	K	E	D	N	I	E
Query Conservation
Alig confidence																																	.	.	.	.	.
Template Conservation																																	.	.	.	.	.
Template Sequence		R	E	L	N	G	T	Y	A	I	A	G	G	R	T	H	A	S	P	A	D	L	C	H	Y	H	S	Q	E	S	D	G	.	.	.	.	.	L	V	C	L	L	K	K	P	F	N	R	P	Q	G	V	Q	P	K	T	P	Q	L	E	K
Template Known Secondary structure				T	T	T					T	T	S			B	S	S									T	T			T	T	.	.	.	.	.	S	S	S				S	B					T	T
Template Predicted Secondary structure																																	.	.	.	.	.
Template SS confidence
		68	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.						.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.
		444	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	V	G	K	K	L	H	E	Y	N	T	Q	F	Q	E	K	S	R	E	Y	D	R	L	Y	E	E	Y	T	R	T	S	Q	E	I	Q	M	K	R	T	A	I	E	A	F	N	E	T	I	K	I	F	E	E	Q	C	Q	T	Q	E	R
Query Conservation
Alig confidence							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		L	I	A	T	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure						T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		157	.	.	160	.
		504	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	S	K	E	Y	I	E	K	F	K	R	E	G	N	E	K	E	I	Q	R	I	M	H	N	H	D	K	L	K	S	R	I	S	E	I	I	D	S	R	R	R	L	E	E	D	L	K	K	Q	A	A	E	Y	R	E	I	D	K	R	M
Query Conservation
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		564	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	S	I	K	P	D	L	I	Q	L	R	K	T	R	D	Q	Y	L	M	W	L	T	Q	K	G	V	R	Q	K	K	L	N	E	W	L	G	N	E	N	T	E	D	Q	Y	S	L	V	E	D	D	E	D	L	P	H	H	D	E	K	T
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	A	H	E	K	M	P
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	G	G	G		T
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
																																																								162	.	.	.	.	.
		624	.	.	.	.	.	630	.	.	.	.	.	.	.	.			.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.
Predicted Secondary structure																	.	.
Query SS confidence																	.	.
Query Sequence		W	N	V	G	S	S	N	R	N	K	A	E	N	L	L	.	.	R	G	K	R	D	G	T	F	L	V	R	E	S	S	K	Q	G	C	Y	A	C	S	V	V	V	D	G	E	V	K	H	C	V	I	N	K	T	A	T	G	Y	G	F
Query Conservation																	.	.
Alig confidence																	.	.
Template Conservation
Template Sequence		W	F	H	G	K	I	S	R	E	E	S	E	Q	I	V	L	I	G	S	K	T	N	G	K	F	L	I	R	A	R	D	N	N	G	S	Y	A	L	C	L	L	H	E	G	K	V	L	H	Y	R	I	D	K	D	K	T	G	K	L	S
Template Known Secondary structure		T																S	S				T	T								S	S	S	S									T	T											T	T	S
Template Predicted Secondary structure
Template SS confidence
		168	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.
		682	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	E	P	Y	N	L	Y	S	S	L	K	E	L	V	L	H	Y	Q	H	T	S	L	V	Q	H	N	D	S	L	N	V	T	L	A	Y	P	V	Y
Query Conservation
Alig confidence																							.	.	.	.	.
Template Conservation																							.	.	.	.	.
Template Sequence		I	P	E	G	K	K	F	D	T	L	W	Q	L	V	E	H	Y	S	Y	K	A	.	.	.	.	.	D	G	L	L	R	V	L	T	V	P	C	Q
Template Known Secondary structure			T	T	S			B	S										T	T			.	.	.	.	.	T	T	S	S	S				S	B
Template Predicted Secondary structure																							.	.	.	.	.
Template SS confidence
		228	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.						.	250	.	.	.	.	.	.	.	.	.	260

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D