|   |   |
11 | . | . | . | . | . | . | . | . | 20 | . | |
. | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | 30 | . | . | . | . | |
|
|
|
|
| Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  | . |  |
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
| . | . | . | . | . |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
| Query Sequence |   |
L | R | R | V | F | V | V | G | V | G | M | . |
T | K | F | M | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
K | P | G | G | E | N | S | R | D | . |
. |
. |
. |
. |
| Query Conservation |   |
|
|
|
|   |
|
|
|
|
|   | . |
|
|
|   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|   |
|   |   |   |   |   |
| . | . | . | . | . |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
| . | . | . | . | . |
| Template Conservation |   |
|
|
|
|   |
|
|
|   |
|   |   |
|
|   |
|   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |
| Template Sequence |   |
M | K | R | A | V | I | T | G | L | G | I | V | S | S | I | G | N | N | Q | Q | E | V | L | A | S | L | R | E | G | R | S | G | I | T | F | S | Q | E | L | K | D | S | G | M | R | S | H | V | W | G | N | V | K | L | D | T | T | G | L | I |
| Template Known Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  | B | T | T | B | S | S |  |  |  |  |  |  |  |  |  |  | T |
|
|
|  |  |  |
|  |  |  |  |  | T | T |
| S |
|
|  |  |  |
|
|
|
|
|
| T | T | S | S |
| Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|  |  |  |
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 |
|   |
|   |   |
|
|
|
|
|
|
|
|
|
|
35 | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | |
|
|
|
|
. | . | 60 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
| Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |
| . | . | . | . | . |
|  |  |  |  |  |  |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . |
| Query SS confidence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
| Query Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
Y | P | D | M | A | K | E | A | G | Q | K | A | L | E | D | A | Q | I | P | Y | S | A | V | . |
. |
. |
. |
. |
E | Q | A | C | V | G | Y | V | Y | G | D | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
| Query Conservation |   |
. | . | . | . | . | . | . | . | . | . |   |   |
|
|
|   |
|
|   |   |   |
|
|   |
|
|
|
|   |   |   |
|
| . | . | . | . | . |
|   |
|   |   |
|   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . |
| Alig confidence |   |
. | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . |
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |
|   |   |   |
|
|   |
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
D | R | K | V | V | R | F | M | S | D | A | S | I | Y | A | F | L | S | M | E | Q | A | I | A | D | A | G | L | S | P | E | A | Y | Q | N | N | P | R | V | G | L | I | A | G | S | G | G | G | S | P | R | F | Q | V | F | G | A | D | A | M |
| Template Known Secondary structure |   |
|  |  |  |  | T | T |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|
|  |  |  |  | T | T |
| T | T |  |  |  |  |  |  |
| S | S |
|
|  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
61 | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 |
|   |
|   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
69 | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 |
| Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
S | T | S | G | Q | R | A | I | Y | H | S | L | G | L | T | G | I | P | I | I | N | V | N | N | N | C | S | T | G | S | T | A | L | F | M | A | H | Q | L | I | Q | G |
| Query Conservation |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |
|
|   |   |
|
|
|   |   |   |
|   |   |   |
|   |   |   |
|
|
|
|   |   |
|
|   |   |
|   |   |   |
|   |
|
| Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|   |   |   |   |
|   |
| . |
|   |   |   |
|   |   |
|
|
|
|
|
|   |
|
|   |   |
|   |   |   |
|   |   |
| Template Sequence |   |
R | G | P | R | G | L | K | A | V | G | P | Y | V | V | T | K | A | M | A | S | G | V | S | A | C | L | A | T | P | F | K | I | H | G | . |
V | N | Y | S | I | S | S | A | C | A | T | S | A | H | C | I | G | N | A | V | E | Q | I | Q | L |
| Template Known Secondary structure |   |
T | S | T | T | T |  |  |  |  |
| T | T |  |  |  |  |  | S | T | T |  |  |  |  |  |  |  | T | T | T | T |
|
| S | . |
|  |  |
|
|
|
| G | G | G |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
| Template Predicted Secondary structure |   |
 |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
121 | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | |
. | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
111 | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | |
|
. | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
G | L | A | N | C | V | L | A | L | G | F | E | K | M | E | R | G | S | I | G | T | . |
. |
K | F | S | D | R | T | T | P | T | D | K | H | I | E | V | L | I | D | K | Y | G | L | S | A | H | P | I | T | P | Q | M | F | G | Y | A | G | K |
| Query Conservation |   |
|   |   |
|
|
|
|
|   |
|   |
|   |
|
|   |   |   |   |   |   | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . |
| Template Conservation |   |
|   |   |
|   |
|
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |   |   |   |
|   |   | . | . | . | . | . | . | . | . | . |
| Template Sequence |   |
G | K | Q | D | I | V | F | A | G | G | G | E | E | L | C | W | E | M | A | C | E | F | D | A | M | G | A | L | S | T | K | Y | N | D | T | P | E | K | A | S | R | T | Y | D | A | H | R | D | G | F | V | . |
. |
. |
. |
. |
. |
. |
. |
. |
| Template Known Secondary structure |   |
T | S |
| S |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  | T | T |
| B |
|
| S |
| T | T | S | G | G | G | S |
|
| T | T |
| T | T |
|
| S | B |
| . | . | . | . | . | . | . | . | . |
| Template Predicted Secondary structure |   |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  | . | . | . | . | . | . | . | . | . |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | |
|
|
|
|
|
|
|
|
|   |
|   |   |
169 | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |
|
|
|  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | H | M | E | K | Y | G | T | K | V | E | H | F | A | K | I | G | W | K | N | H | K | H | S | V | N | N | T | Y | S | Q | F | Q | D | E | Y | S | L | E | E | V | M | K | S | K | P | V | F | D | F | L | T | I | L | Q | C | C | P | T | S |
| Query Conservation |   |
  |
|
|   |   |
|
|   |
|   |
|   |
|
|   |
|
|
|
|   |   |   |   |
|   |   |
|
|   |
|   |   |
|   |   |   |
|   |
|
|
|
|   |
|   |   |
|
|   |
|
|
|   |   |
|   |
|   |   |
|
| Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
| Template Conservation |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |
|
| Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
I | A |
| Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| B |
| Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
231 | . |
|   |
|   |   |
229 | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |
|  |  |  |  |  |  |
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
D | G | A | A | A | A | I | L | S | S | E | E | F | V | Q | Q | Y | G | L | Q | S |
| Query Conservation |   |
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |
|   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|
|   |   |
|
|
|
|   |   |   |   |
|   |   |
|
|
|   |
|
| Template Sequence |   |
G | G | G | G | M | V | V | V | E | E | L | E | H | A | L | A | R | G | A | H | I |
| Template Known Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |
|
|
|
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
233 | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . |
|   |