Job Description P32020 Confidence 99.92% Date Tue Jul 30 13:21:56 BST 2013 Rank 45 Aligned Residues 309 % Identity 22% Template c3hhdC_ PDB info PDB header:transferase, hydrolase Chain: C: PDB Molecule:fatty acid synthase; PDBTitle: structure of the human fatty acid synthase ks-mat didomain2 as a framework for inhibitor design. Resolution 2.15 Å

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		38	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.					.	60	.	.	.	.	.	.																						.	.	.	70	.	.
Predicted Secondary structure																							.	.	.	.									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																							.	.	.	.									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		M	A	K	E	A	G	Q	K	A	L	E	D	A	Q	I	P	Y	S	A	V	E	.	.	.	.	Q	A	C	V	G	Y	V	Y	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	G	D	S	T	S	G
Query Conservation																							.	.	.	.									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																							.	.	.	.									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		L	L	L	E	V	T	Y	E	A	I	V	D	G	G	I	N	P	D	S	L	R	G	T	H	T	G	V	W	V	G	V	S	G	S	E	T	S	E	A	L	S	R	D	P	E	T	L	V	G	Y	S	M	V	G	C	Q	R	A	M	M
Template Known Secondary structure														T	T			G	G	G	G	T	T	S																		T	S		T	T	T			T							S	T	T
Template Predicted Secondary structure
Template SS confidence
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
		73	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	R	A	I	Y	H	S	L	G	L	T	G	I	P	I	I	N	V	N	N	N	C	S	T	G	S	T	A	L	F	M	A	H	Q	L	I	Q	G	G	L	A	N	C	V	L	A	L	G	F	E	K	M	E	R	G	S	I	G	T	K
Query Conservation
Alig confidence														.
Template Conservation														.
Template Sequence		A	N	R	L	S	F	F	F	D	F	R	G	.	P	S	I	A	L	D	T	A	C	S	S	S	L	M	A	L	Q	N	A	Y	Q	A	I	H	S	G	Q	C	P	A	A	I	V	G	G	I	N	V	L	L	K	P	N	T	S	V	Q
Template Known Secondary structure										T			S	.								G	G	G															T	T	S		S
Template Predicted Secondary structure														.
Template SS confidence
		141	.	.	.	.	.	.	.	.	150	.	.		.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.
		133	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	S	D	R	T	T	P	T	D	K	H	I	E	V	L	I	D	K	Y	G	L	S	A	H	P	I	T	P	Q	M	F	G	Y	A	G	K	E	H	M	E	K	Y	G	T	K	V	E	H	F	A	K	I	G	W	K	N	H	K	H	S
Query Conservation
Alig confidence											.	.	.																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation											.	.	.																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		F	L	R	L	G	M	L	S	P	.	.	.	E	G	T	C	K	A	F	D	T	A	G	N	G	Y	C	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure						T		B		T	.	.	.	T	S				T	T	B	T	T				B		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure											.	.	.																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		200	.	.	.	.	.	.	.	.				.	210	.	.	.	.	.	.	.	.	.	220	.	.	.
		193	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		V	N	N	T	Y	S	Q	F	Q	D	E	Y	S	L	E	E	V	M	K	S	K	P	V	F	D	F	L	T	I	L	Q	C	C	P	T	S	D	G	A	A	A	A	I	L	S	S	E	E	F	V	Q	Q	Y	G	L	Q	S	K	A	V
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	R	S	E	G	V	V	A	V	L	L	T	K	K	S	L	A	.	.	.	.	R	R	V	Y	A	T
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	B	B											G	G	G		.	.	.	.	S	S		S
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																	.	.	.	.
Template SS confidence
																																				224	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.					240	.	.	.	.	.
		253	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	I	V	A	Q	E	M	M	T	D	L	P	S	T	F	E	E	K	S	I	I	K	V	V	G	Y	D	M	S	K	E	A	A	R	R	C	Y	E	K	S	G	L	T	P	N	D	V	D	V	I	E	L	H	D	C	F	S	V	N	E
Query Conservation
Alig confidence		.										.	.	.	.																																													.	.
Template Conservation		.										.	.	.	.																																													.	.
Template Sequence		.	I	L	N	A	G	T	N	T	D	.	.	.	.	G	F	K	E	Q	G	V	T	F	P	S	G	D	I	Q	E	Q	L	I	R	S	L	Y	Q	S	A	G	V	A	P	E	S	F	E	Y	I	E	A	H	G	T	G	T	K	.	.
Template Known Secondary structure		.										.	.	.	.				T	T		T	T	S																		T			G	G	G												T	.	.
Template Predicted Secondary structure		.										.	.	.	.																																													.	.
Template SS confidence
			246	.	.	.	250	.	.	.	.					.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.
		313	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	I	T	Y	E	A	L	G	L	C	P	E	G	Q	G	G	T	L	V	D	R	G	D	N	T	Y	G	G	K	W	V	I	N	P	S	G	G	L	I	S	K	G	H	P	L	G	A	T	G	L	A	Q	C	A	E	L	C	W	Q	L
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.																																.	.
Template Conservation		.	.	.	.	.	.	.	.																																.	.
Template Sequence		.	.	.	.	.	.	.	.	V	G	D	P	Q	E	L	N	G	I	T	R	A	L	C	A	T	R	Q	E	P	L	L	I	G	S	T	K	S	N	M	.	.	G	H	P	E	P	A	S	G	L	A	A	L	A	K	V	L	L	S	L
Template Known Secondary structure		.	.	.	.	.	.	.	.	T														S	S	S		S	S							T					.	.		B		G	G	G
Template Predicted Secondary structure		.	.	.	.	.	.	.	.																																.	.
Template SS confidence
										299	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.			330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.
		373	.	.	.	.	.	.	380	.	.																														.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.
Predicted Secondary structure												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		R	G	E	A	G	K	R	Q	V	P	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	G	A	K	V	A	L	Q	H	N	L	G	L	G	G	A	V	V	V	T	L	Y
Query Conservation												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence			.	.	.	.						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation			.	.	.	.
Template Sequence		E	.	.	.	.	H	G	L	W	A	P	N	L	H	F	H	S	P	N	P	E	I	P	A	L	L	D	G	R	L	Q	V	V	D	Q	P	L	P	V	R	G	G	N	V	G	I	N	S	F	G	F	G	G	S	N	V	H	I	I	L
Template Known Secondary structure			.	.	.	.		T	B					S	S			S	B		T	T							T	S						S			B			S										T	T	S
Template Predicted Secondary structure			.	.	.	.
Template SS confidence
		349					350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.
		404	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	M	G	F	P	E	A	A	S	S	F	R	T	H	Q	V	S	A	A	P	T	S	S	A	G	D	G	F	K	A	N	L	V	F	K	E	I	E	K	K	L	E
Query Conservation
Alig confidence																		.	.	.
Template Conservation																		.	.	.
Template Sequence		R	P	N	T	Q	P	P	P	A	P	A	P	H	A	T	L	.	.	.	P	R	L	L	R	A	S	G	R	T	P	E	A	V	Q	K	L	L	E	Q	G	L	R
Template Known Secondary structure													S	G	G	G	S	.	.	.									S	S
Template Predicted Secondary structure																		.	.	.
Template SS confidence
		405	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420				.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.