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Job DescriptionQ62077
Confidence100.00%DateTue Jul 30 13:20:18 BST 2013
Rank1Aligned Residues728
% Identity34%Templatec3ohmB_
PDB info PDB header:signaling protein / hydrolaseChain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3
Resolution2.70 Å
Model Dimensions (Å)X:114.883 Y:87.783 Z:59.211

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   25....30.........40.........50.........60.........70.........80....
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Query Sequence  LCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPG
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Template Sequence  VVETLRRGSKFIKWDEETSSRN. LVTLRVDPNGFFLYWTGP. NMEVDTLDISSIRDTRTG
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TT

S

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TTS

G.GG
GGGT
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   18.20.........30......... 40.........50....... ..60.........70.....
 
   85....90.........100.........110..... ....120.........130.........140...
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Query Sequence  KTSRDFDRYQEDPAFRPDQSHCFVILYGMEF. RLKTLSLQATSEDEVNMWIKGLTWLMED
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Template Sequence  RYARLPK. . . DPKIREVLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMN
Template Known Secondary structure  TTS



...S


TT
SSGGG
SSSS
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   76...80.. .......90.........100.........110.........120.........130..
 
   144.....150.........160.. .......170.........180.. .......190.........
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Query Sequence  TLQAATPLQIERWLRKQFY. . SVDRNREDRISAKDLKNMLS. . QVNYRVPNMRFLRERLT
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Template Sequence  ILAQNAS. . RNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNR
Template Known Secondary structure  T

..S

TTS
TTGGGTTT


ST
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   142...... .150.........160.........170.........180.........190.........
 
   200.........210.........220.........230.........240.........250.........
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Query Sequence  DLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNALRTGERPEHCQVSLSEFQQFLL
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Template Sequence  SESIRPDEFSLEIFERFLNKL. . CLRPDIDKILLEI. . . . . . GAKGKPYLTLEQLMDFIN
Template Known Secondary structure  T

GGG

..S

T......T

STT
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   200.........210.........220 .........230... ......240.........250.
 
   260........ .270.........280.........290.........300.........310..
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Query Sequence  EYQGELWAV. . . . . . . DRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNS
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Template Sequence  QKQRDPRLNEVLYPPLRPSQARLLIEKY. EPNQQFLERDQMSMEGFSRYLGGEENGILPL
Template Known Secondary structure  SS
TTS
TTTS



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TT
TSTTS
SS
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   252.......260.........270......... 280.........290.........300.........310
 
   313......320.........330.........340.........350.........360.........370.
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Query Sequence  QLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG.
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Template Sequence  EALDLSTD. MTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGR
Template Known Secondary structure  SS
S
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S
GGG

BSSTTBSS
SS
B
STT




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   311....... .320.........330.........340.........350.........360.........
 
   372.......380.........390.........400.........410....... ..420.........
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Query Sequence  . PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHC. SIAQQRNMAQHF
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Template Sequence  PPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYC
Template Known Secondary structure  SSS



STTS

TTSS

S



TT
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   370.........380.........390.........400.........410.........420.........
 
   430.........440.... .....450.........460.........470.........480.....
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Query Sequence  RKVLGDTLLTKPVDI. . . . AADGLPSPNQLRRKILIKHKKLAEGSAYEEVPTSVMYSEND
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Template Sequence  RSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHT. . . . . . . . . . . . . . . . .
Template Known Secondary structure  GGGB

S
BTTB
SSSS




TTTTTT






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   430.........440.........450.........460.........470..
 
   486...490.........500.........510.........520.........530.........540.....
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Query Sequence  ISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELH
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Template Conservation  ............................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
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   546...550.........560.........570.........580.........590.........600.....
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Query Sequence  SSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKV
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
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   606...610.........620.........630.........640.........650.........660.....
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Query Sequence  QHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHES
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
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   666...670.........680.........690.........700.........710.........720.....
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Query Sequence  KEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVM
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   726...730.........740.........750.........760.........770.........780.....
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Query Sequence  LGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVE
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
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   786...790.........800.........810.........820.........830.........840.....
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Query Sequence  ANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNY
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
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   846...850.........860.........870.........880.........890.........900.....
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Query Sequence  VEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVA
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ............................................................
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   906...910.........920.........930.........940.........950.........960.....
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Query Sequence  QWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPF
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DEGTASSEVNATEEMSTLVNYIEPVKF
Template Known Secondary structure  .................................TTGGGTT




TT
SS



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   576...580.........590.........600..
 
   966...970.........980.........990.........1000.........1010.........1020.....
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Query Sequence  DEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDP
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Template Sequence  KSFEAARKRNKCFEMSSFVETKAMEQL. TKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMP
Template Known Secondary structure 

T
TT.SS


TT
TT




T
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   603......610.........620......... 630.........640.........650.........660.
 
   1026...1030.........1040.........1050.........1060.........1070... ......1080...
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Query Sequence  LPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEA. . FDPFDKSSLR
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Template Sequence  QLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVD
Template Known Secondary structure  TTT
S
B
TT

STTGGG
S

GGGT
TT



TT
SS

T
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   662.......670.........680.........690.........700.........710.........720.
 
   1084.....1090.........1100.........1110.........1120...... ...1130.........1140..
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Query Sequence  GLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ. KTEFVVDNGLNPVWPA
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Template Sequence  GIVANALRVKVISGQFLSDRK. . . VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDE
Template Known Secondary structure  T


S

SS
...

SSTTT
B







SS
SSS
B


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   722.......730.........740.. .......750.........760.........770........
 
   1143.... ..1150.........1160.........1170.........1180.........1190.........1200.
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Query Sequence  KPFHF. QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLE
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Template Sequence  EPFDFPKVVLPTLASLRIAAFEEG. . . . GKFVGHRILPVSAIRSGYHYVCLRNEANQPLC
Template Known Secondary structure 

S
GGG
TT....TTTT



TTS
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   779780.........790.........800.. .......810.........820.........830....
 
   1202.......1210.........1220.........1230.........1240.........1250...
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Query Sequence  LASLLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARY
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Template Sequence  LPALLIYTEAS. . . . . . DYIPDDHQDYAEALINPIKHVSLMDQRARQLAALI
Template Known Secondary structure  ......


GGG
T
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   835....840..... ....850.........860.........870.........880
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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