Email l.a.kelley@imperial.ac.uk Description O88890 Date Wed Jul 10 14:08:25 BST 2013 Unique Job ID 8b2bbfb33b9c3421

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1ka6A_ 100.0 94 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 2 d1d4ta_ 100.0 95 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 3 d1a81e1 100.0 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 4 d2oq1a1 100.0 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 5 d1i3za_ 100.0 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 6 c2ysxA_ 100.0 42 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 7 c2oq1A_ 100.0 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 8 c2dlyA_ 100.0 27 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 9 d1a81a1 100.0 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 10 c4fl2A_ 100.0 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 11 c2gsbA_ 99.9 25 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 12 d2oq1a2 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 13 d1a81e2 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 14 c2ozoA_ 99.9 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 15 d1blja_ 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 16 d1lkka_ 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 17 c2eo6A_ 99.9 25 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 18 d1csya_ 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 19 d1a81a2 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 20 c2ge9A_ 99.9 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 21 d1rjaa_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 22 d1opka2 not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 23 c2augB_ not modelled 99.9 23 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 24 d1k9aa2 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 25 d1nrva_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 26 d1jwoa_ not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 27 d1o48a_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 28 d2shpa2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 29 c2ablA_ not modelled 99.9 33 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 30 d1qcfa2 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 d1f2fa_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 32 c2fo0A_ not modelled 99.9 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 33 d2qmsa1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 c1a81E_ not modelled 99.9 27 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 35 d1luia_ not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 36 c2eobA_ not modelled 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 37 d3c7ia1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 38 d1fhsa_ not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 39 c2dm0A_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 40 d1g83a2 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 41 c3hizB_ not modelled 99.9 27 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 42 d1bkla_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 43 c2ekxA_ not modelled 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 44 c1x27F_ not modelled 99.9 23 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 45 c2eo3A_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 46 c1y57A_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 47 c3nhnA_ not modelled 99.9 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 48 c2lqnA_ not modelled 99.9 19 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 49 d2izva2 not modelled 99.9 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 50 c2hdxB_ not modelled 99.9 24 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 51 c1oplA_ not modelled 99.9 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 52 c1x6cA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 53 c2y3aB_ not modelled 99.9 31 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 54 c2shpA_ not modelled 99.9 26 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 55 c2crhA_ not modelled 99.9 23 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 56 c2h8hA_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 57 d2fcia1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 c2c9wA_ not modelled 99.9 18 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 59 c2dlzA_ not modelled 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 60 d1pica_ not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 c2el8A_ not modelled 99.9 15 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 62 c2hmhA_ not modelled 99.9 19 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 63 c3mazA_ not modelled 99.9 18 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 64 c2c0iA_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 65 d1ayaa_ not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 c2knoA_ not modelled 99.9 22 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 67 c2lctA_ not modelled 99.9 23 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 68 c1k9aB_ not modelled 99.9 30 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 69 c2ci8A_ not modelled 99.9 28 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 70 c2vifA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 71 d2cs0a1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 72 d2eyva1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 73 c3ps5A_ not modelled 99.9 20 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 74 c2izvA_ not modelled 99.9 19 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 75 c2b3oA_ not modelled 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 76 d1jyra_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d2shpa3 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 c2kk6A_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 79 c3gqiB_ not modelled 99.9 26 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 80 d1mila_ not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 81 d1cwea_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 c1g83A_ not modelled 99.9 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 83 d1r1qa_ not modelled 99.9 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1fu6a_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 d1qada_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 86 c2dcrA_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 87 d1rpya_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 d2c9wa2 not modelled 99.9 16 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c1rqqC_ not modelled 99.8 29 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 90 c2eyzA_ not modelled 99.8 21 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 91 d1xa6a2 not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 92 c2dvjA_ not modelled 99.8 19 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 93 c3qwxX_ not modelled 99.7 24 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 94 c2eyyA_ not modelled 99.7 20 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 95 c3qwyA_ not modelled 99.7 25 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 96 c3gxxB_ not modelled 99.7 12 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 97 c2cr4A_ not modelled 99.7 19 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 98 c2dx0B_ not modelled 99.7 26 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 99 c3or8A_ not modelled 99.6 11 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 100 c2xp1A_ not modelled 99.6 14 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 101 d1bf5a3 not modelled 99.5 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 102 c1xa6A_ not modelled 99.4 34 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 103 d1uura3 not modelled 99.4 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 104 d1bg1a3 not modelled 99.2 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 c3cblA_ not modelled 99.1 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide 106 c2cblA_ not modelled 98.2 14 PDB header:complex (proto-oncogene/peptide) Chain: A: PDB Molecule:proto-oncogene cbl; PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70 107 c3bunB_ not modelled 98.2 14 PDB header:ligase/signaling protein Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl; PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4 108 c1uusA_ not modelled 98.1 19 PDB header:signal transduction Chain: A: PDB Molecule:stat protein; PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form 109 c1y1uA_ not modelled 97.9 27 PDB header:signaling protein Chain: A: PDB Molecule:signal transducer and activator of transcription 5a; PDBTitle: structure of unphosphorylated stat5a 110 c1bg1A_ not modelled 97.7 22 PDB header:transcription/dna Chain: A: PDB Molecule:protein (transcription factor stat3b); PDBTitle: transcription factor stat3b/dna complex 111 c1yvlB_ not modelled 97.7 32 PDB header:signaling protein Chain: B: PDB Molecule:signal transducer and activator of transcription PDBTitle: structure of unphosphorylated stat1 112 c1bf5A_ not modelled 97.6 33 PDB header:gene regulation/dna Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: tyrosine phosphorylated stat-1/dna complex 113 c3cwgA_ not modelled 96.2 34 PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment 114 c1fbvA_ not modelled 94.0 14 PDB header:ligase Chain: A: PDB Molecule:signal transduction protein cbl; PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases 115 d3buxb3 not modelled 91.8 14 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 116 c3op0B_ not modelled 87.0 16 PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide 117 c1griA_ not modelled 80.4 21 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 118 c1x60A_ not modelled 35.7 17 PDB header:hydrolase Chain: A: PDB Molecule:sporulation-specific n-acetylmuramoyl-l-alanine PDBTitle: solution structure of the peptidoglycan binding domain of2 b. subtilis cell wall lytic enzyme cwlc 119 d1wlha1 not modelled 34.9 21 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 120 c1ksrA_ not modelled 33.3 21 PDB header:actin binding protein Chain: A: PDB Molecule:gelation factor; PDBTitle: the repeating segments of the f-actin cross-linking2 gelation factor (abp-120) have an immunoglobulin fold, nmr,3 20 structures