BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (126 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_O88890 SH2 domain-containing protein 1A n=11 Tax=Eutele...   261   3e-69
UniRef50_O60880 SH2 domain-containing protein 1A n=36 Tax=root R...   226   1e-58
UniRef50_UPI0000F2E785 PREDICTED: hypothetical protein n=1 Tax=M...   205   4e-52
UniRef50_UPI00016E9D38 UPI00016E9D38 related cluster n=1 Tax=Tak...   139   3e-32
UniRef50_C1BZH2 SH2 domain-containing protein 1A n=3 Tax=Euteleo...   118   5e-26
UniRef50_UPI00003A9BD4 PREDICTED: similar to SH2 domain-containi...   112   3e-24
UniRef50_O14796 SH2 domain-containing protein 1B n=17 Tax=Theria...   107   1e-22
UniRef50_UPI0000EAFFB4 SH2 domain-containing protein 1B (EWS/FLI...   107   2e-22
UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   100   1e-20
UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun seq...    98   7e-20
UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...    98   8e-20
UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tet...    92   3e-18
UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosph...    92   4e-18
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...    84   1e-15
UniRef50_O15357 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...    82   4e-15
UniRef50_O60880-5 Isoform E of SH2 domain-containing protein 1A ...    81   1e-14
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...    70   2e-11
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...    69   4e-11
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...    67   2e-10
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS           65   5e-10
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...    65   5e-10
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...    65   6e-10
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO           65   6e-10
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...    65   7e-10
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...    65   8e-10
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...    65   8e-10
UniRef50_UPI0000E1FA37 PREDICTED: similar to signaling inositol ...    63   3e-09
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...    62   5e-09
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...    62   8e-09
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...    62   8e-09
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...    61   8e-09
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...    61   9e-09
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...    61   1e-08
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...    61   1e-08
UniRef50_UPI000194BAA4 PREDICTED: KIAA1524 n=1 Tax=Taeniopygia g...    60   1e-08
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...    60   2e-08
UniRef50_Q4SNX7 Chromosome 15 SCAF14542, whole genome shotgun se...    60   3e-08
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...    60   3e-08
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...    59   5e-08
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI          59   6e-08
UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichop...    58   1e-07
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...    57   1e-07
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...    56   3e-07
UniRef50_C4QKJ6 Proto-oncogene tyrosine-protein kinase abl1, put...    56   4e-07
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...    56   4e-07
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...    55   6e-07
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    55   7e-07
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...    54   1e-06
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...    54   1e-06
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...    54   1e-06
UniRef50_A9V255 Predicted protein n=1 Tax=Monosiga brevicollis R...    53   3e-06
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...    53   3e-06
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...    52   5e-06
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...    52   7e-06
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    52   7e-06
UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostom...    52   8e-06
UniRef50_Q4SYS7 Chromosome undetermined SCAF11965, whole genome ...    52   8e-06
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...    51   9e-06
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...    50   1e-05
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...    50   2e-05
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...    50   2e-05
UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepI...    50   3e-05
UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n...    49   4e-05
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...    49   4e-05
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...    49   4e-05
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...    49   5e-05
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...    48   7e-05
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...    48   8e-05
UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=...    48   1e-04
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...    48   1e-04
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    47   2e-04
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...    47   3e-04
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...    47   3e-04
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...    46   3e-04
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE         46   4e-04
UniRef50_UPI0001552956 PREDICTED: similar to EAT2b n=1 Tax=Mus m...    46   4e-04
UniRef50_C4Q4M0 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    46   4e-04
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...    45   5e-04
UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa ...    45   6e-04
UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine ki...    45   7e-04
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN          45   8e-04
UniRef50_UPI0001760433 PREDICTED: similar to beta chimerin n=1 T...    45   8e-04
UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax...    45   0.001
UniRef50_A8PJS1 RhoGAP domain containing protein n=5 Tax=Chromad...    44   0.001
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...    44   0.001
UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound p...    44   0.001
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...    44   0.001
UniRef50_UPI0001555F0B PREDICTED: similar to SH2 domain-containi...    44   0.001
UniRef50_UPI000180D2FE PREDICTED: similar to SYK n=1 Tax=Ciona i...    44   0.002
UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.002
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...    44   0.002
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...    44   0.002
UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS          44   0.002
UniRef50_A9V2L8 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.002
UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_S...    44   0.002
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...    44   0.002
UniRef50_UPI000192628F PREDICTED: similar to chimerin (chimaerin...    44   0.002
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    44   0.002
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...    44   0.002
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...    44   0.002
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...    43   0.003
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...    43   0.003
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...    43   0.003
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...    43   0.003
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...    43   0.003
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...    43   0.003
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    43   0.003
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...    43   0.004
UniRef50_Q5C0L2 SJCHGC05893 protein (Fragment) n=1 Tax=Schistoso...    42   0.004
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...    42   0.004
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...    42   0.004
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...    42   0.005
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...    42   0.005
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...    42   0.005
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...    42   0.005
UniRef50_UPI000180D0F7 PREDICTED: similar to dual adaptor of pho...    42   0.006
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...    42   0.006
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...    42   0.006
UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain...    42   0.007
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...    42   0.007
UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=...    42   0.007
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...    42   0.008
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...    42   0.009
UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein act...    41   0.009
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...    41   0.009
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...    41   0.011
UniRef50_C4QAI3 Chimerin-related rho-gtpase-activating protein n...    41   0.011
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...    41   0.011
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...    41   0.012
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...    40   0.016
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...    40   0.017
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...    40   0.017
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...    40   0.018
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...    40   0.022
UniRef50_Q1KL02 Chimerin 2 n=3 Tax=Tetraodontidae RepID=Q1KL02_T...    40   0.033
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...    40   0.033
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...    39   0.035
UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347...    39   0.040
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...    39   0.041
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...    39   0.043
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...    39   0.046
UniRef50_UPI0000E48B80 PREDICTED: hypothetical protein n=1 Tax=S...    39   0.048
UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X...    39   0.051
UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specif...    39   0.051
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...    39   0.052
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...    39   0.059
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...    38   0.083

>UniRef50_O88890 SH2 domain-containing protein 1A n=11 Tax=Euteleostomi
           RepID=SH21A_MOUSE
          Length = 126

 Score =  261 bits (668), Expect = 3e-69,   Method: Compositional matrix adjust.
 Identities = 126/126 (100%), Positives = 126/126 (100%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE
Sbjct: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD
Sbjct: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120

Query: 121 ICLNAP 126
           ICLNAP
Sbjct: 121 ICLNAP 126


>UniRef50_O60880 SH2 domain-containing protein 1A n=36 Tax=root RepID=SH21A_HUMAN
          Length = 128

 Score =  226 bits (577), Expect = 1e-58,   Method: Compositional matrix adjust.
 Identities = 112/128 (87%), Positives = 115/128 (89%), Gaps = 2/128 (1%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MDAV VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY GYIYTYRVSQTE
Sbjct: 1   MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE-KSSGRGPQAPTG-RRD 118
           TGSWSAETAPGVHKR+FRK+KNLISAFQKPDQGIV PLQYPVE KSS R  Q  TG R D
Sbjct: 61  TGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIRED 120

Query: 119 SDICLNAP 126
            D+CL AP
Sbjct: 121 PDVCLKAP 128


>UniRef50_UPI0000F2E785 PREDICTED: hypothetical protein n=1 Tax=Monodelphis domestica
           RepID=UPI0000F2E785
          Length = 197

 Score =  205 bits (521), Expect = 4e-52,   Method: Compositional matrix adjust.
 Identities = 95/104 (91%), Positives = 100/104 (96%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MD+V+VYHG ISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ+E
Sbjct: 1   MDSVSVYHGNISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQSE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           TGSWSAETAPGV KR FRK+KNLISAFQKPDQGIV PLQ+PVEK
Sbjct: 61  TGSWSAETAPGVQKRLFRKIKNLISAFQKPDQGIVIPLQHPVEK 104


>UniRef50_UPI00016E9D38 UPI00016E9D38 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9D38
          Length = 130

 Score =  139 bits (349), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 64/102 (62%), Positives = 78/102 (76%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+ + VYHG I +E GE+ L   G DG YL+R+S+SVPGVYCLCVL  GY+YTYR+ Q  
Sbjct: 1   MENLPVYHGPIGKEEGERRLGQDGRDGCYLVRNSDSVPGVYCLCVLCHGYVYTYRLYQDH 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
            GSW+A+T PGV KR FR ++NLI+AFQKP QGIV PL YPV
Sbjct: 61  GGSWAADTTPGVPKRSFRHIRNLIAAFQKPGQGIVMPLLYPV 102


>UniRef50_C1BZH2 SH2 domain-containing protein 1A n=3 Tax=Euteleostei
           RepID=C1BZH2_ESOLU
          Length = 147

 Score =  118 bits (296), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 61/109 (55%), Positives = 71/109 (65%), Gaps = 9/109 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           + + VYHG  S+E GE  L   G DGSYL+R+SES  GVYCLCVL         +     
Sbjct: 4   EKLPVYHGATSKEEGELRLWKDGRDGSYLIRNSESRDGVYCLCVL---------LFMDGE 54

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           GSW+AETA GV +R+FRK+KNLISAFQKPDQGI T L YPV     R P
Sbjct: 55  GSWTAETAAGVERRYFRKIKNLISAFQKPDQGIATHLLYPVTVQINRNP 103


>UniRef50_UPI00003A9BD4 PREDICTED: similar to SH2 domain-containing molecule EAT2 n=2
           Tax=Neognathae RepID=UPI00003A9BD4
          Length = 134

 Score =  112 bits (281), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 54/114 (47%), Positives = 79/114 (69%), Gaps = 2/114 (1%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HGKISR+  E LL   G +GSYL+R+SE+V G  CLCVL++  IYTYR+ +   G +  
Sbjct: 6   FHGKISRKACEDLLCKKGKNGSYLIRESETVAGALCLCVLFEKVIYTYRIFREYEGCYKV 65

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK--SSGRGPQAPTGRRD 118
           +T+ GV ++ F+ +K+LI  ++KP+QG+VT L+YPV+K  SS R  +  TG  D
Sbjct: 66  QTSEGVPQKVFKTLKDLIYNYEKPNQGLVTKLRYPVKKTSSSRRSQRFKTGNDD 119


>UniRef50_O14796 SH2 domain-containing protein 1B n=17 Tax=Theria RepID=SH21B_HUMAN
          Length = 132

 Score =  107 bits (266), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 47/100 (47%), Positives = 73/100 (73%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG+++++  E LLL  G+DG++LLRDSES+PGV CLCV ++  +YTYR+ + + G +  
Sbjct: 6   YHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRI 65

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           +TA G  K+ F  +K LIS F+KP+QG+V  L  P++++S
Sbjct: 66  QTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTS 105


>UniRef50_UPI0000EAFFB4 SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2)
           (EAT-2). n=2 Tax=Canis lupus familiaris
           RepID=UPI0000EAFFB4
          Length = 134

 Score =  107 bits (266), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 51/111 (45%), Positives = 72/111 (64%), Gaps = 4/111 (3%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG +S++  E LLL  G+DG++LLRDSES+PGV CLCV ++  +YTYR+ +   G ++ 
Sbjct: 6   YHGPLSKKDCETLLLKDGIDGNFLLRDSESLPGVLCLCVSFKNLVYTYRIFEERRGFYNI 65

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
           +T  G  K  F  +K LIS F+KP QG+V  L  P++K+S      P  RR
Sbjct: 66  QTVEGAPKEIFPNLKELISKFEKPSQGLVMHLIQPIKKASS----CPRWRR 112


>UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2B n=7
           Tax=Clupeocephala RepID=SHP2B_DANRE
          Length = 1226

 Score =  100 bits (249), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 47/115 (40%), Positives = 69/115 (60%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YH  ISR   E+LL   G+DGS+L+RDSESVPG Y LC+L+Q +++TYR+    
Sbjct: 1   MTGAPWYHRDISRVRAEELLAHAGIDGSFLVRDSESVPGAYALCLLFQRHVHTYRILPDA 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
            G  + +   GV    FR + +L+  +Q P++G+V PL YPV + S    ++  G
Sbjct: 61  DGLLAVQATQGVQVNCFRTLGDLVLGYQNPNKGLVAPLLYPVMRESEANDESSDG 115


>UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RP74_TETNG
          Length = 968

 Score = 98.2 bits (243), Expect = 7e-20,   Method: Compositional matrix adjust.
 Identities = 47/112 (41%), Positives = 69/112 (61%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YH  ISR   E+LL   G DGSYL+RDSESVPG Y LC+L+Q +++TYR+    
Sbjct: 9   MATAVWYHRDISRVQAEELLARAGKDGSYLVRDSESVPGAYALCLLFQRHVHTYRILPDA 68

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            G  + +T  GV    FR +++L+  +Q+P +G+V+PL Y V +    G ++
Sbjct: 69  DGLLAVQTTQGVQVNCFRTLEDLVFGYQQPHKGLVSPLLYGVPRDMDIGDES 120


>UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 n=40
           Tax=Euteleostomi RepID=SHIP1_HUMAN
          Length = 1189

 Score = 97.8 bits (242), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 49/110 (44%), Positives = 69/110 (62%), Gaps = 3/110 (2%)

Query: 8   HGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAE 67
           HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY+  +YTYR+   E   ++ +
Sbjct: 7   HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66

Query: 68  TAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV---EKSSGRGPQAPT 114
            + GV  RFF K+  LI  ++K + G+VT LQYPV   E+ +G  P+  T
Sbjct: 67  ASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDT 116


>UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4774
          Length = 132

 Score = 92.4 bits (228), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 40/99 (40%), Positives = 65/99 (65%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG I R+T E+LL     DG+YL+RDSE+VPG  CLCV     +YTYR+ +T +G +  
Sbjct: 5   YHGAIGRKTCEELLGKKNKDGAYLIRDSETVPGAMCLCVFKGRVVYTYRLLKTRSGDYML 64

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
             A G+ + +F+ +++LI  +++ DQG+   L++ V++ 
Sbjct: 65  MVADGIEETYFKNLEDLIRHYKRRDQGLAMHLRHAVQRK 103


>UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosphate 5- phosphatase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BC71
          Length = 1019

 Score = 92.4 bits (228), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 43/96 (44%), Positives = 62/96 (64%)

Query: 8   HGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAE 67
           HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY   +YTYR+   +   ++ +
Sbjct: 7   HGNITRSKAEELLSKTGKDGSFLVRASESISRAYALCVLYHNCVYTYRILPNDDEKFTVQ 66

Query: 68  TAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
            + GV  RFF  ++ LI  ++K + G+VT LQYPV+
Sbjct: 67  ASEGVPMRFFTSLEQLIDFYKKENMGLVTHLQYPVQ 102


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score = 84.3 bits (207), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 36/96 (37%), Positives = 60/96 (62%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG+++R+  E+LLL+  +DGS+++R SES  G Y L VL+   ++TYR+  TE  + + 
Sbjct: 7   YHGRVNRQQSEELLLSAAVDGSFVVRASESRAGAYALSVLFNNSVHTYRILPTENNTLAV 66

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           +T  GV +R F+ +  L+  ++    G+V  L  PV
Sbjct: 67  QTVNGVQQRKFKSLTELVHEYRNSQNGLVCGLSNPV 102


>UniRef50_O15357 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 n=31
           Tax=Euteleostomi RepID=SHIP2_HUMAN
          Length = 1258

 Score = 82.4 bits (202), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 50/118 (42%), Positives = 69/118 (58%), Gaps = 2/118 (1%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           A + YH  +SR   E+LL   G DGS+L+RDSESV G + LCVLYQ +++TYR+      
Sbjct: 18  APSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGED 77

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
             + +T+ GV  R F+ +  LI  + +P+QG+V  L  PVE    R P  P  R  SD
Sbjct: 78  FLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE--REPDPPDDRDASD 133


>UniRef50_O60880-5 Isoform E of SH2 domain-containing protein 1A n=4 Tax=Eutheria
          RepID=O60880-5
          Length = 76

 Score = 81.3 bits (199), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 38/40 (95%), Positives = 39/40 (97%)

Query: 1  MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGV 40
          MDAV VYHGKISRETGEKLLLATGLDGSYLLRDSESVPG+
Sbjct: 1  MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGI 40


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score = 69.7 bits (169), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 6/98 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG+ISRE  EKLL     +G +L+R+S++ PG Y LCV Y G +  YRV + E G  + 
Sbjct: 110 FHGRISREDAEKLLTPPK-NGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNEKGLVTV 168

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +        +F  +  L+  +QK   G+ T L+ PV+K
Sbjct: 169 DD-----DEYFDNLIKLVEHYQKEADGLCTRLKAPVDK 201


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score = 68.9 bits (167), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 36/120 (30%), Positives = 68/120 (56%), Gaps = 7/120 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D+   YHG+I R T E   L+ G++GS+L+R+S+S  G + + +   G ++ YR+S+T+
Sbjct: 174 LDSEPYYHGRIPRTTAE-FFLSNGINGSFLVRESQSNAGEHTISLRCDGKVFHYRISRTD 232

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G + A        R F  V++L+  + +   G+V PL++ V K+      +P+ + + D
Sbjct: 233 KGVFIAAD------RVFSTVQDLVKFYHQQSDGLVHPLRHAVPKNRQEITASPSDKWEID 286


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score = 67.0 bits (162), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 37/104 (35%), Positives = 56/104 (53%), Gaps = 6/104 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E  LL++G+DGS+L+RDSES PG   + + + G +Y YR+S   
Sbjct: 182 LEKHSWYHGPISRNAAE-YLLSSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGS 240

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            G     T     +  F  +  L+    K   G++T L+YP  K
Sbjct: 241 DGKVFVTT-----ESKFSTIAELVHHHCKQSDGLITTLRYPAAK 279


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score = 65.5 bits (158), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 36/102 (35%), Positives = 56/102 (54%), Gaps = 8/102 (7%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR+S+   G    
Sbjct: 263 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFV 321

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQ--GIVTPLQYPVEKSS 106
                  +  F  +  L+     P +  G++TPL YP  K +
Sbjct: 322 -----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQN 358


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score = 65.5 bits (158), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 40/98 (40%), Positives = 54/98 (55%), Gaps = 6/98 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG +SR+ GE LL  +G+ GS+L+R SES PG   + V + G +Y YR+SQ   G +  
Sbjct: 242 YHGAVSRQAGEHLL-RSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 300

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
             A   H+  F  V  LI    +   G+V PL Y V K
Sbjct: 301 TEA---HR--FPTVVQLIEHHSRSADGLVCPLLYSVPK 333


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score = 65.5 bits (158), Expect = 6e-10,   Method: Compositional matrix adjust.
 Identities = 36/102 (35%), Positives = 56/102 (54%), Gaps = 8/102 (7%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR+S+   G    
Sbjct: 255 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFV 313

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQ--GIVTPLQYPVEKSS 106
                  +  F  +  L+     P +  G++TPL YP  K +
Sbjct: 314 -----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQN 350


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score = 65.5 bits (158), Expect = 6e-10,   Method: Compositional matrix adjust.
 Identities = 36/100 (36%), Positives = 55/100 (55%), Gaps = 8/100 (8%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR+S+   G    
Sbjct: 254 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFV 312

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQ--GIVTPLQYPVEK 104
                  +  F  +  L+     P +  G++TPL YP  K
Sbjct: 313 -----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPK 347


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score = 65.1 bits (157), Expect = 7e-10,   Method: Compositional matrix adjust.
 Identities = 40/98 (40%), Positives = 54/98 (55%), Gaps = 6/98 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG +SR+ GE LL  +G+ GS+L+R SES PG   + V + G +Y YR+SQ   G +  
Sbjct: 79  YHGAVSRQAGEHLL-RSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 137

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
             A   H+  F  V  LI    +   G+V PL Y V K
Sbjct: 138 TEA---HR--FPTVVQLIEHHSRSADGLVCPLLYSVPK 170


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score = 64.7 bits (156), Expect = 8e-10,   Method: Compositional matrix adjust.
 Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 7/102 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HGKISRE  E LL+    DG +L+R+S   PG Y LCV +Q  +  YR+ Q + G  + 
Sbjct: 102 FHGKISRELAESLLMPRE-DGLFLVRESAHFPGDYTLCVCFQDQVDHYRM-QGKNGKLTI 159

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
           +      + +F  ++ L+  ++K   G+ T L+ PV K  GR
Sbjct: 160 D-----EEVYFSSLEELVQHYEKDADGLCTRLRKPVVKQGGR 196


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score = 64.7 bits (156), Expect = 8e-10,   Method: Compositional matrix adjust.
 Identities = 36/100 (36%), Positives = 54/100 (54%), Gaps = 8/100 (8%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y G +Y YR+S+   G    
Sbjct: 274 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDPDGKVFV 332

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQ--GIVTPLQYPVEK 104
                  +  F  +  L+     P +  G++TPL YP  K
Sbjct: 333 -----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPK 367


>UniRef50_UPI0000E1FA37 PREDICTED: similar to signaling inositol polyphosphate 5
          phosphatase SIP-145 n=1 Tax=Pan troglodytes
          RepID=UPI0000E1FA37
          Length = 177

 Score = 62.8 bits (151), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 29/62 (46%), Positives = 40/62 (64%)

Query: 8  HGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAE 67
          HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY+  +YTYR+   E   ++ +
Sbjct: 7  HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66

Query: 68 TA 69
           A
Sbjct: 67 DA 68


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score = 62.0 bits (149), Expect = 5e-09,   Method: Compositional matrix adjust.
 Identities = 37/102 (36%), Positives = 55/102 (53%), Gaps = 12/102 (11%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS--W 64
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y G +Y YR+S+   G    
Sbjct: 198 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDSDGKVYV 256

Query: 65  SAETAPGVHKRFFRKVKNLI--SAFQKPDQGIVTPLQYPVEK 104
           +AE         F  +  L+   +      G++TPL YP  K
Sbjct: 257 TAEAK-------FNTLAELVHHHSVLHEGHGLITPLLYPAPK 291


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score = 61.6 bits (148), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 32/98 (32%), Positives = 52/98 (53%), Gaps = 6/98 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG +SR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR++    G    
Sbjct: 128 YHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 186

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            +     +  F  +  L+        G++T L YP  K
Sbjct: 187 SS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPK 219


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 61.6 bits (148), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 31/96 (32%), Positives = 52/96 (54%), Gaps = 6/96 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +H  ISRE  EKLL     DG++L+R+S + PG + LC+ Y G +  YR+ QT  G  + 
Sbjct: 149 FHSMISRENTEKLLRGKP-DGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSGGQLTC 207

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           +      + +F  +  L+S +++   G+   L  P+
Sbjct: 208 DK-----EEYFSNLTQLVSHYKRDADGLCHRLVTPI 238


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score = 61.2 bits (147), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 6/104 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 461 LEKHSWYHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 519

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            G     +     +  F  +  L+        G++T L YP  K
Sbjct: 520 DGKLYVSS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPK 558


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score = 61.2 bits (147), Expect = 9e-09,   Method: Compositional matrix adjust.
 Identities = 32/98 (32%), Positives = 52/98 (53%), Gaps = 6/98 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG +SR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR++    G    
Sbjct: 14  YHGPVSRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 72

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            +     +  F  +  L+        G++T L YP  K
Sbjct: 73  SS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPK 105


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score = 61.2 bits (147), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 35/99 (35%), Positives = 54/99 (54%), Gaps = 7/99 (7%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-TETGSWS 65
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR+++ T  G   
Sbjct: 175 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDTSDGKVY 233

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
             T     +  F  +  L+        G++T L YP  K
Sbjct: 234 VTT-----ESRFNTLAELVHHHSMHSDGLITQLLYPAPK 267


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score = 60.8 bits (146), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 34/106 (32%), Positives = 57/106 (53%), Gaps = 10/106 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 374 LEKHSWYHGPVSRNAAEHLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 432

Query: 61  TGSW--SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            G    S+E+        F  +  L+        G++T L YP  K
Sbjct: 433 DGKLYVSSESR-------FNTLAELVHHHSTVADGLITTLHYPAPK 471


>UniRef50_UPI000194BAA4 PREDICTED: KIAA1524 n=1 Tax=Taeniopygia guttata RepID=UPI000194BAA4
          Length = 801

 Score = 60.5 bits (145), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 26/58 (44%), Positives = 41/58 (70%)

Query: 47  YQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           ++  IYTYR+ +   G +  +T+ GV  R F+ +K+LI AF+KP+QG+V  L+YPV+K
Sbjct: 582 FEDLIYTYRIFREHQGYFRIQTSEGVPDRTFKTLKDLIYAFEKPNQGLVINLRYPVKK 639


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score = 60.1 bits (144), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 40/119 (33%), Positives = 60/119 (50%), Gaps = 12/119 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D  T YHGKISR   E +L  +G+ GS+L+R+SE+  G Y + V + G ++ YR++   
Sbjct: 189 LDKYTWYHGKISRSDSEAIL-GSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDN 247

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV-EKSSGRG-----PQAP 113
           T     E      +  FR +  L+        G++  L YP  +K  GRG     P AP
Sbjct: 248 T-----EKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNAP 301


>UniRef50_Q4SNX7 Chromosome 15 SCAF14542, whole genome shotgun sequence.
          (Fragment) n=3 Tax=Euteleostomi RepID=Q4SNX7_TETNG
          Length = 63

 Score = 59.7 bits (143), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 26/52 (50%), Positives = 37/52 (71%)

Query: 5  TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          ++Y+G+I  E  E LL   G DGS+LLRDSE+V G YCLCV    +++T+R+
Sbjct: 10 SIYYGRIGSEVTEMLLARFGRDGSFLLRDSETVAGAYCLCVRKAPFVHTFRL 61


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score = 59.7 bits (143), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 33/96 (34%), Positives = 52/96 (54%), Gaps = 7/96 (7%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG I+RE  EK+L     DG++L+RDS + PG Y LC+ + G +  YR+ Q   G  + 
Sbjct: 47  YHGNITREHTEKILSGQA-DGTFLVRDSTNFPGDYTLCMAFNGKVEHYRIYQL-NGILTC 104

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           +     H+  F  +  LI+ +++   G+   L  PV
Sbjct: 105 D-----HEETFDNLTQLIAHYKRDADGLCHRLITPV 135


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score = 58.9 bits (141), Expect = 5e-08,   Method: Compositional matrix adjust.
 Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 10/100 (10%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS--W 64
           YHG +SR   E  LL++ ++GS+L+R+SES PG   + + Y+G +Y YR++ T  G    
Sbjct: 174 YHGPVSRSAAE-YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +AE+        F  +  L+        G+VT L YP  K
Sbjct: 233 TAESR-------FSTLAELVHHHSTVADGLVTTLHYPAPK 265


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score = 58.5 bits (140), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 26/56 (46%), Positives = 39/56 (69%), Gaps = 1/56 (1%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           YHG ISR   E  LL++G++GS+L+R+SES PG   + + Y+G +Y YR+S+   G
Sbjct: 255 YHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDG 309


>UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S7K1_TRIAD
          Length = 864

 Score = 57.8 bits (138), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 10/120 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+ +  Y+  +S E  E LL     DG++L+R S  VPG + L + Y+   + +R+ +  
Sbjct: 1   MENLANYYIDVSYEQAEDLLRLEDQDGAFLIRPSHRVPGTFALSIRYRNKFFHHRI-KVF 59

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G +  E   G  ++ F  +  L+  F++P+QG+  PL   V       P  PT   +S+
Sbjct: 60  HGRFVCE---GFTEKTFSSMDELVKHFRQPNQGLAHPLTKSV------SPPTPTEEDESN 110


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score = 57.4 bits (137), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 32/98 (32%), Positives = 51/98 (52%), Gaps = 6/98 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG I R   E  LL +G+ GS+L+R+SES PG   + + Y+G I+ YR+ + ++  +  
Sbjct: 168 YHGAIQRSYAE-YLLNSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDDSNMYYV 226

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
                +    F  V +L+   +K   G+   L YP  K
Sbjct: 227 -----IESNKFTSVSDLVHHHEKHSDGLACTLLYPAPK 259


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 38/104 (36%), Positives = 56/104 (53%), Gaps = 9/104 (8%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYT-YRVSQTETGSWS 65
           YH  ISR T E  LL +G+DGS+L+R+S S PG Y + +   G   T YR++    G + 
Sbjct: 129 YHSNISRNTAE-YLLKSGVDGSFLVRESLSSPGEYSITLRCDGKARTHYRINHDARGYFV 187

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL-QYPVEKSSGR 108
           A        +FF  V+ L++       G+V  L Q+PVEK+  +
Sbjct: 188 AAG------KFFATVEQLVAHHAVVADGLVACLKQHPVEKAEAK 225


>UniRef50_C4QKJ6 Proto-oncogene tyrosine-protein kinase abl1, putative n=1
           Tax=Schistosoma mansoni RepID=C4QKJ6_SCHMA
          Length = 316

 Score = 55.8 bits (133), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 27/56 (48%), Positives = 37/56 (66%), Gaps = 1/56 (1%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           YHG +SR+ GE LL  +G+ GS+L+R SES PG   + V + G +Y YR+SQ   G
Sbjct: 242 YHGAVSRQAGEHLL-RSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRG 296


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score = 55.8 bits (133), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-ETGSWS 65
          +HGKISRE  E++L   G DG +L+R+S S  G Y L VL++G +  Y + +  +   +S
Sbjct: 10 FHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGDDAFFS 69

Query: 66 AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
                +H      + +LI  +QK    +VT LQ
Sbjct: 70 IHDHTPIH-----GLDSLIEHYQKDKGNLVTRLQ 98


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score = 55.1 bits (131), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 33/106 (31%), Positives = 54/106 (50%), Gaps = 6/106 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  T YHG +SR   E  LL++G++GS+L+RDSES  G   + V +   +Y YR++   
Sbjct: 82  LNMHTWYHGAVSRAAAE-YLLSSGINGSFLVRDSESCRGHLSVSVRFNASVYHYRINVDT 140

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
            G +        H+  F+ +  L+        G+   L YP  KS+
Sbjct: 141 AGLFYISPE---HR--FQTLPELVHHHSYASDGLAAILHYPAAKST 181


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score = 55.1 bits (131), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 38/106 (35%), Positives = 54/106 (50%), Gaps = 6/106 (5%)

Query: 7   YHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           YHG+ISR   E+LL   G L GS+L+RDS +  G Y L + +QG  Y Y +S+   GS +
Sbjct: 10  YHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISRHPDGSVA 69

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
            +         F     LI    K   G++T L+ P  +  G+ PQ
Sbjct: 70  IQDGAK-----FDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQ 110



 Score = 43.5 bits (101), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 7/93 (7%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           +HG ISRE  E+ + A GL DG +L+R+   V   + LCV  +  IY Y +     G  S
Sbjct: 164 FHGAISREESEQRMKAFGLRDGLFLVRERTEV-NSFALCVAVKNDIYHYLLEMNTLGQLS 222

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
            E       R F  +  ++  + +   G++  L
Sbjct: 223 IENG-----RKFENLLQVVDHYSRTPDGLLCTL 250


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score = 54.3 bits (129), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 32/108 (29%), Positives = 53/108 (49%), Gaps = 7/108 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + A+  +HGKI+R   E LL     DG +L+R+S + PG Y +CV + G +  YRV   +
Sbjct: 103 LTAMPWFHGKITRSDAEDLLTPRK-DGLFLVRESTNYPGDYTMCVSFAGEVEHYRVIFKD 161

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
                 E      + +F  +  L+  +++   G+V  L  P+ K  G 
Sbjct: 162 NKVTIDE------EEYFENLTKLVEHYERDADGLVCTLTQPLIKKGGH 203


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata
          RepID=B0WXZ2_CULQU
          Length = 1063

 Score = 54.3 bits (129), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 30/94 (31%), Positives = 54/94 (57%), Gaps = 6/94 (6%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-ETGSWS 65
          +HGKISRE  E++L   G DG +++R+S S  G + L VL+Q  +  Y++ +  +   +S
Sbjct: 10 FHGKISRERAEEILRQEGGDGVFMVRESASSEGDFVLSVLFQDEMVHYQIRRHGDDAFFS 69

Query: 66 AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
           +    +H      +++LI  +++   G+VT LQ
Sbjct: 70 IDDHTPIH-----GLESLIEHYRESPNGLVTKLQ 98


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
          corporis RepID=UPI000186ED21
          Length = 751

 Score = 53.9 bits (128), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 28/98 (28%), Positives = 56/98 (57%), Gaps = 6/98 (6%)

Query: 2  DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV-SQTE 60
          + ++ +HGK+SR+  EKL+     +G +L+R+S + PG + L +L+ G I  Y++    E
Sbjct: 5  ECISWFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGE 64

Query: 61 TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
             +S +     ++  F  ++ LI+  Q+ + G++T L
Sbjct: 65 DAFFSID-----NEHIFHGLETLINYHQENENGLITKL 97


>UniRef50_A9V255 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V255_MONBE
          Length = 192

 Score = 52.8 bits (125), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 34/104 (32%), Positives = 53/104 (50%), Gaps = 8/104 (7%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG+I+RE     LL  G+DGS+LLR S +  GVY L ++    +   R+  T  G ++ 
Sbjct: 5   YHGRITREEAVDRLLKEGVDGSFLLRMSTTQDGVYTLSLMQGESVRHIRIVNTIDGGYAI 64

Query: 67  ETA-PGVHKRF----FRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
               PGV   +     +    L SA+ + DQ     L+YP++ +
Sbjct: 65  SAGDPGVDSVWQLVETQMHNTLTSAYDRSDQ---VALRYPLKAN 105


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score = 52.8 bits (125), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 6/100 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +    S+     LL   G DG++L+R+SES PG Y L V YQG +  Y++   +     +
Sbjct: 283 FMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLSVFYQGKLKHYKIKHDQDMYRVS 342

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           E      +  F  +  LI   +    G+VT L+ PV+ ++
Sbjct: 343 E------RHTFASISELIEYHKHNGGGLVTRLRKPVQDAN 376


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score = 52.4 bits (124), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 31/92 (33%), Positives = 52/92 (56%), Gaps = 7/92 (7%)

Query: 8   HGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           HGKISRE  + L+ + G  +G +L+R+S   PG Y L V+ QG +  +++S+ +TG +  
Sbjct: 32  HGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALSVVAQGKLQHFKISR-KTGLYRI 90

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
           +  PG     F  +  L+  ++ PD  + T L
Sbjct: 91  DDGPG-----FGSLDELVQFYRNPDDRLPTVL 117


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score = 51.6 bits (122), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 29/98 (29%), Positives = 50/98 (51%), Gaps = 7/98 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG I+R+  E LL     DG +L+R+S + PG Y LCV +Q  +  YRV   E
Sbjct: 474 LNAMPWFHGSITRDEAEHLLQPRE-DGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 532

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
                 +      + +F  +  L++ ++    G+ T L
Sbjct: 533 NKLTIDD------EEYFENLGQLVAHYEADADGLCTQL 564


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 51.6 bits (122), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 39/138 (28%), Positives = 58/138 (42%), Gaps = 29/138 (21%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG ++R   E LLL+ G DGSYLLRDS    G+Y L V  +  +  + V  T       
Sbjct: 36  YHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT------- 88

Query: 67  ETAPGVHKRF----FRKVKNLISAFQK-----PDQGIVTPLQYP---------VEKSSGR 108
               G   +F    F  +K+ +  F        + G +  L++P         + +S   
Sbjct: 89  ----GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRV 144

Query: 109 GPQAPTGRRDSDICLNAP 126
                TGR + D+   AP
Sbjct: 145 HTAMQTGRTEDDLVPTAP 162


>UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostomi RepID=KSYK_HUMAN
          Length = 635

 Score = 51.6 bits (122), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 7/111 (6%)

Query: 7   YHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           +HGKISRE  E++ L+ +  +G +L+R  ++  G Y LC+L++G +  YR+ + +TG  S
Sbjct: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLS 227

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
                    + F  +  L+  +     G++  L  P +K   +G     GR
Sbjct: 228 IPEG-----KKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273


>UniRef50_Q4SYS7 Chromosome undetermined SCAF11965, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SYS7_TETNG
          Length = 1017

 Score = 51.6 bits (122), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 26/72 (36%), Positives = 43/72 (59%), Gaps = 4/72 (5%)

Query: 47  YQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           +Q +++TYR+   E G  + +T+ GV  + F+K+  L+S + +P+QG+VT L Y V+   
Sbjct: 1   FQKHVHTYRILPDEEGFLAVQTSQGVQPKRFKKLPELVSLYLQPNQGLVTTLLYAVD--- 57

Query: 107 GRGPQAPTGRRD 118
            R   A T  RD
Sbjct: 58  -REETAFTDERD 68


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score = 51.2 bits (121), Expect = 9e-06,   Method: Compositional matrix adjust.
 Identities = 29/98 (29%), Positives = 50/98 (51%), Gaps = 7/98 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG I+R+  E LL     DG +L+R+S + PG Y LCV +Q  +  YRV   E
Sbjct: 679 LNAMPWFHGSITRDEAEHLLQPRE-DGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 737

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
                 +      + +F  +  L++ ++    G+ T L
Sbjct: 738 NKLTIDD------EEYFENLGQLVAHYEADADGLCTQL 769


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score = 50.4 bits (119), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 30/103 (29%), Positives = 53/103 (51%), Gaps = 4/103 (3%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-- 59
           D +  YHG +SRE  ++LL     DG++L+R+S +  G + L +L QG +  Y+V +   
Sbjct: 6   DPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGG 65

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           E   +S +    V  +    +  L+  +Q+   G+ T L  P+
Sbjct: 66  EDAFFSIDDK--VQTKILHGLDTLVDYYQQAANGLPTKLTVPL 106


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score = 50.4 bits (119), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 33/107 (30%), Positives = 50/107 (46%), Gaps = 18/107 (16%)

Query: 8   HGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAE 67
           HG ISR   + LL   G+DG YL+R+S+S PG Y L V  +G    YR+++ + G     
Sbjct: 76  HGAISRNGADYLLKQHGIDGMYLVRESQSQPGQYTLDVWKEGKSVHYRITKGDEG----- 130

Query: 68  TAPGVHKRFFRK------VKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
                   FFR+      +  LI   Q    G+ + L +   K+  +
Sbjct: 131 -------YFFRQGVCFPTIPELIQHHQTRSDGLCSSLDHIAPKAHAK 170


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score = 50.1 bits (118), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 33/102 (32%), Positives = 50/102 (49%), Gaps = 6/102 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +DA   + GKI R   EK+L  +    GS+L+RDSE+ PG + L V  Q  +  YRV + 
Sbjct: 117 LDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRL 176

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           E GS          +  F+ +  L+  ++    G+   L YP
Sbjct: 177 EDGSLFV-----TRRSTFQILHELVDHYKIETDGLCCKLLYP 213


>UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepID=HTK16_HYDAT
          Length = 757

 Score = 49.7 bits (117), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 6/94 (6%)

Query: 2  DAVTVYHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
          DA+  YHGKI+RE   ++LL   G DG +L+RD  + P  Y L ++++  I  ++++   
Sbjct: 6  DALLWYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRSQILHFQINCLG 65

Query: 61 TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI 94
             +S +  P      F+ +  LIS ++    G+
Sbjct: 66 DNKFSIDNGP-----IFQGLDMLISYYKVISDGL 94



 Score = 40.8 bits (94), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 29/114 (25%), Positives = 53/114 (46%), Gaps = 9/114 (7%)

Query: 8   HGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           H  + R  G  ++L  A+  DGS+L+R S    G Y L ++Y+   Y +++       + 
Sbjct: 289 HQNLDR-NGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKTYHFQIKSRADRWFY 347

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG-PQAPTGRRD 118
            +  P      F  + +L+  + +   G+ T LQ+PV  +  R  P  PT  ++
Sbjct: 348 IDDGP-----LFETLPHLVDHYMQYADGLPTLLQFPVPSAENRKRPLPPTPTKN 396


>UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925DBE
          Length = 249

 Score = 49.3 bits (116), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 23/53 (43%), Positives = 33/53 (62%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +HG ++R T E LLLA G++G+YL+R+S S PG Y + V  Q  I  Y +   
Sbjct: 55  FHGDMTRNTSEALLLANGVEGTYLVRNSASDPGSYTVSVRCQSSIKHYSLRHN 107


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score = 49.3 bits (116), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 30/114 (26%), Positives = 57/114 (50%), Gaps = 10/114 (8%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           +H K+SRE  E+ +++ GL +G +L+R+  +  G + L + Y  ++Y Y++ +  TG  S
Sbjct: 212 FHHKLSREEAEQRIVSAGLQEGKFLVRE-RTEEGSFALSLCYNNFVYHYKIDKDCTGQLS 270

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
            +  P      F  +  ++  +Q    G++  L  P   ++      PT RR S
Sbjct: 271 IKEGPK-----FDSLIQMVDHYQLKKDGLLCCLLVPCHDNNR---DTPTRRRHS 316



 Score = 41.6 bits (96), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 6/107 (5%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           YHG+I+RE  E  L   G   G +LLR+S    G Y L + Y+  +Y Y + +   G+ +
Sbjct: 57  YHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYEDDVYHYAIERQYDGTVA 116

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            +      K F   ++ L+S     + G++  L  P     G   +A
Sbjct: 117 IKDG----KNFAGPIE-LVSNHMNREDGLLCRLLRPCNLQQGIAARA 158


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score = 49.3 bits (116), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 23/61 (37%), Positives = 35/61 (57%), Gaps = 1/61 (1%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG+I RE  E LL     DG +L+R+S + PG Y LCV +   +  YR+   E
Sbjct: 373 LNAMPWFHGRIKREEAENLLKPRE-DGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKYAE 431

Query: 61  T 61
            
Sbjct: 432 N 432


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1
          Tax=Acyrthosiphon pisum RepID=UPI0001793830
          Length = 686

 Score = 48.9 bits (115), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 24/55 (43%), Positives = 34/55 (61%), Gaps = 2/55 (3%)

Query: 4  VTVYHGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          +  YHGKISR+T E +LL   +  DG +L+R+S S  G Y LCVL    +  Y++
Sbjct: 10 INWYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQNNEVVHYQI 64


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score = 48.1 bits (113), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 9/103 (8%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVSQTETGS 63
           + GKI+RE  E+LL    + G +L+R+S + PG Y LCV+       +  YRV  T    
Sbjct: 93  FFGKITREKAEELLTPREV-GLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVISTSDNQ 151

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
            + +      + FF  +  LI  ++K   G+ T L+ P++K +
Sbjct: 152 VTVD-----EEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKT 189


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score = 48.1 bits (113), Expect = 8e-05,   Method: Composition-based stats.
 Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 9/109 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           +D    + GKI+RE  E+LL    + G +L+R+S + PG Y LCV+       +  YRV 
Sbjct: 27  LDLANWFFGKITREKAEELLTPREV-GLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 85

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
            T     + +        FF  +  LI  +++   G+ T L+ P++K +
Sbjct: 86  STNDNRVTVD-----EDAFFPNLIELIKHYERDADGLCTMLKKPLKKKT 129


>UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=35 Tax=Euteleostomi
           RepID=Q64725-2
          Length = 606

 Score = 47.8 bits (112), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 33/126 (26%), Positives = 63/126 (50%), Gaps = 9/126 (7%)

Query: 7   YHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           +HG ISR+  E+ +L+ +  +G +L+R  ++  G + LC+L++G +  YR+ + +TG  S
Sbjct: 168 FHGNISRDESEQTVLIGSKTNGKFLIRARDN-NGSFALCLLHEGKVLHYRIDRDKTGKLS 226

Query: 66  A------ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR-D 118
                  +T   + + +  K   L+     P Q I   + +P   ++   P  P G R +
Sbjct: 227 IPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPVPPPPQGSRPE 286

Query: 119 SDICLN 124
           S +  N
Sbjct: 287 STVSFN 292



 Score = 40.0 bits (92), Expect = 0.025,   Method: Compositional matrix adjust.
 Identities = 28/111 (25%), Positives = 50/111 (45%), Gaps = 6/111 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +T + G I+RE  E  L+  G+ DG YLLR S +  G + L V +    + Y + +  
Sbjct: 10  NHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIEREL 69

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
            G+++         R      +L     +  +G+V  L+ P  +  G  P+
Sbjct: 70  NGTYAISGG-----RAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPK 115


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score = 47.8 bits (112), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 8/97 (8%)

Query: 7   YHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           Y+G I+R   EKLLLA+   DGS+L+R SES    Y +    +G ++ +R+ ++  G++ 
Sbjct: 251 YYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGAYF 310

Query: 66  AETAPGVHKRF-FRKVKNLISAFQKPDQGIVTPLQYP 101
                 V  R  F  +  LIS +Q+ ++ +   L+ P
Sbjct: 311 ------VSDRISFATLGELISYYQRNNRSLGVLLEEP 341


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
          RepID=Q9Y1Y2_9METZ
          Length = 743

 Score = 47.0 bits (110), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 30/94 (31%), Positives = 47/94 (50%), Gaps = 9/94 (9%)

Query: 2  DAVTVYHGKISRETGEKLLLA---TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
          DA   YHGKI+RE    L+     T  +G +L+R+S   PG Y L +  +G +  +++  
Sbjct: 6  DAERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQIMG 65

Query: 59 TETGSWSAETAPGVHKRFFRKVKNLISAFQ-KPD 91
             G +S +  P      F+ +  LI  +Q KPD
Sbjct: 66 HGEGWFSVDNGP-----LFQGLDELIHHYQLKPD 94


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score = 46.6 bits (109), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 33/102 (32%), Positives = 49/102 (48%), Gaps = 4/102 (3%)

Query: 7   YHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           + GKI+R   EK L       GS+L+R+SES PG Y L +     +  YRV   E G + 
Sbjct: 238 FFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRDGDTVRHYRVENYEGGLYK 297

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
            + +P    + F  +  LI+   +   G+ T L+ P  K S 
Sbjct: 298 LQGSP---TQKFASLPELIAFHGQRKAGLATALREPCPKESA 336


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2
          Tax=Endopterygota RepID=UPI0000D57699
          Length = 725

 Score = 46.6 bits (109), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 25/69 (36%), Positives = 39/69 (56%), Gaps = 2/69 (2%)

Query: 7  YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRV-SQTETGSW 64
          YHGK+SRE  E LL   G  DGS+L+R+S S  G + L VL+   +  +++   +E   +
Sbjct: 10 YHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHSEDAFF 69

Query: 65 SAETAPGVH 73
          S +    +H
Sbjct: 70 SIDENTKIH 78


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score = 46.2 bits (108), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 47/97 (48%), Gaps = 11/97 (11%)

Query: 7   YHGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           +HGKI+RE  E+LL    TGL   +L+R+S + PG Y LCV   G +  YR+       +
Sbjct: 83  FHGKITREQAERLLYPPETGL---FLVRESTNYPGDYTLCVSCDGKVEHYRI------MY 133

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
            A       + +F  +  L+  +     G+ T L  P
Sbjct: 134 HASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score = 45.8 bits (107), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 18/113 (15%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  YHG +SR   E LL+A   DGSYLLR S +  G Y L V  +  +  +++    
Sbjct: 9   VEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSVKHFQI---- 64

Query: 61  TGSWSA---ETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKS 105
              W     +   GV    F+ ++  +  F        + GI+T L++P  ++
Sbjct: 65  --GWDGKQYQFGMGV----FQSLQEFVEHFANQPLIGGESGILTALRHPYSRN 111


>UniRef50_UPI0001552956 PREDICTED: similar to EAT2b n=1 Tax=Mus musculus
           RepID=UPI0001552956
          Length = 124

 Score = 45.8 bits (107), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 20/59 (33%), Positives = 33/59 (55%)

Query: 47  YQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           ++  +Y YR+ + + G +  ET P   K  F  ++ LIS F+ P QG+V  L  P+ +S
Sbjct: 38  FKKLVYNYRIFREKNGYYRIETEPSTPKTIFPNLEELISKFKTPGQGMVVHLSNPIMRS 96


>UniRef50_C4Q4M0 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4Q4M0_SCHMA
          Length = 921

 Score = 45.8 bits (107), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 5/96 (5%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG ISRE  E+LL     +G++L+R S S    Y L V+Y   +Y Y + +   G +  
Sbjct: 64  FHGNISREDTERLLKHHLQNGTFLIRFSISTHK-YVLSVIYNQQLYHYPIEELSDGFYQV 122

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
               G + ++   +  L+S F++ +  IV  L  PV
Sbjct: 123 N---GTNAKYL-GIDLLVSEFRRANNCIVCSLGKPV 154


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score = 45.4 bits (106), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 11/101 (10%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTYRVSQTET 61
           YH  I+R   E LL     +G++++RDS  + G Y + V       +  I  Y++ + ++
Sbjct: 151 YHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARSTEAAIKHYQIKKNDS 209

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           G W         +  F+ +  LI   Q    G++T L+YPV
Sbjct: 210 GQWYV-----AERHAFQSIPELIWYHQHNAAGLMTRLRYPV 245


>UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa RepID=O77440_HYDAT
          Length = 624

 Score = 45.4 bits (106), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 7/117 (5%)

Query: 7   YHGKISRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           +HG+I+R+  E  L  T    DG+YLLR+S S  G Y L V     +  Y + +  +G  
Sbjct: 10  FHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSVCKDKKVIHYAIQRQPSGMV 69

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDI 121
                P      F     L++  +    G++T L YP E+ +G    A  G    D+
Sbjct: 70  GIADGPQ-----FPGPVELVNHHKTSLGGLMTKLTYPCERPAGVKATAYKGISHDDL 121



 Score = 41.2 bits (95), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 5/99 (5%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG I R   E+ L +    G +L+R+  S  G Y + + YQG +Y Y       G  S 
Sbjct: 162 FHGVIPRTEAERRLKSLSETGMFLIRERGSPRGSYVIGLFYQGGVYHYLFESNNQGQLSI 221

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           ++      R F  +  +++ + +  +G+   L+   E S
Sbjct: 222 KSG-----RSFDNLMAVVNFYSQKSEGLFCTLKRACEVS 255


>UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine kinase n=3
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48523
          Length = 837

 Score = 45.1 bits (105), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 28/111 (25%), Positives = 52/111 (46%), Gaps = 7/111 (6%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           +HG + R+   + +   G  DG +LLR S + P    L +   G ++ + ++ T+  S+ 
Sbjct: 352 FHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEIN-TKMESFY 410

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
            +  P     +F  ++ LI  + + D G+ T L +P+    GR    P  R
Sbjct: 411 IDDGP-----YFDTLEQLIDHYSRYDDGLPTMLLHPIPPPPGRIDNGPPTR 456


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score = 45.1 bits (105), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 27/103 (26%), Positives = 52/103 (50%), Gaps = 4/103 (3%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-- 59
           +++  +HG +SRE  + LL     DG++L+R+S +  G + L +L Q  +  Y+V +   
Sbjct: 6   ESMKWFHGNLSREAADDLLKQGYEDGTFLVRESSTAAGDFVLSLLCQEEVCHYQVRRHGG 65

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           E   +S +    V  +    +  L+  +Q+   G+ T L  P+
Sbjct: 66  EDAFFSIDDK--VQTKILHGLDTLVDYYQQAANGLPTKLTVPL 106


>UniRef50_UPI0001760433 PREDICTED: similar to beta chimerin n=1 Tax=Danio rerio
           RepID=UPI0001760433
          Length = 594

 Score = 45.1 bits (105), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 21/50 (42%), Positives = 32/50 (64%), Gaps = 2/50 (4%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
           +HG ISRE  ++LL   G +G+YL+R+S+  PG Y L + + G    YR+
Sbjct: 73  FHGLISREQADELL--AGTEGAYLIRESQRQPGTYTLALRFGGQTLNYRL 120


>UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax=Euteleostomi
           RepID=GRB10_HUMAN
          Length = 594

 Score = 44.7 bits (104), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 19/51 (37%), Positives = 32/51 (62%), Gaps = 1/51 (1%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
           +HG+ISRE   +++   GL DG +LLRDS+S P  + L + +   I  +++
Sbjct: 494 FHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544


>UniRef50_A8PJS1 RhoGAP domain containing protein n=5 Tax=Chromadorea
          RepID=A8PJS1_BRUMA
          Length = 407

 Score = 44.3 bits (103), Expect = 0.001,   Method: Composition-based stats.
 Identities = 19/52 (36%), Positives = 31/52 (59%), Gaps = 1/52 (1%)

Query: 5  TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          T +HG I RE  + +LL  G +G++L+R S   PG   LC+ + G +  Y++
Sbjct: 40 TEFHGLIEREVADNMLLEAG-EGAFLVRASRRSPGANTLCMFFDGRVLNYKL 90


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score = 44.3 bits (103), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 6/105 (5%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           + A   + G I R   EK LL +    GS+L+R+SES  G + L VL    +  YR+ + 
Sbjct: 111 LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRL 170

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           + G +         +R F  +   +S + K   G+   L  P  K
Sbjct: 171 DEGGFFL-----TRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLK 210


>UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound protein 14 isoform 1 n=1
           Tax=Pan troglodytes RepID=UPI0000E1F79D
          Length = 491

 Score = 44.3 bits (103), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 1/71 (1%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           +H KISR+  ++L++  GL DG +L+RDS+S P  + L + +   I  +++   E     
Sbjct: 391 FHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGEM 450

Query: 66  AETAPGVHKRF 76
             T    H RF
Sbjct: 451 FHTLDDGHTRF 461


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score = 44.3 bits (103), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 32/105 (30%), Positives = 49/105 (46%), Gaps = 8/105 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +A   Y G + R   EK L+  GL  G++L+R +E+  G + L V     +  YRV + +
Sbjct: 122 EAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLSVRDGDSVKHYRVRKLD 181

Query: 61  TGSWSAET-APGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           TG +   T AP      F  +  L+  + K   G+V  L  P  K
Sbjct: 182 TGGYFITTRAP------FNSLYELVQHYTKDADGLVCALTLPCPK 220


>UniRef50_UPI0001555F0B PREDICTED: similar to SH2 domain-containing molecule EAT2 n=1
           Tax=Ornithorhynchus anatinus RepID=UPI0001555F0B
          Length = 254

 Score = 44.3 bits (103), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 19/51 (37%), Positives = 34/51 (66%)

Query: 51  IYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           +YTYR+ + + G +S ET  G+    F  ++ LI+ ++K +QG+VT L++P
Sbjct: 82  VYTYRIFREKPGYFSVETMEGIPTERFPNLRELIAKYKKANQGLVTRLRHP 132


>UniRef50_UPI000180D2FE PREDICTED: similar to SYK n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2FE
          Length = 635

 Score = 43.9 bits (102), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 5/97 (5%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG ISR    +L+    +DGS+LLR S   P  Y + V YQG +  Y +  +    W +
Sbjct: 11  YHGPISRSEATELVKGQ-VDGSFLLRKSLREPDGYAISVSYQGSVLHYSIQHSTVSGWYS 69

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
                 H       + L   + +   G+ T L +P++
Sbjct: 70  VNKGSEHP----SPQALCKYYMQEKGGLKTKLLWPIK 102


>UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2C7_MONBE
          Length = 592

 Score = 43.9 bits (102), Expect = 0.002,   Method: Composition-based stats.
 Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 4/82 (4%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + YHG ISRE   + L     DG++LLR S +    Y + +   G I   RV+ T  G +
Sbjct: 432 SYYHGTISREEAVRRLQEVNTDGAFLLRLSATQKDAYTISLQSNGEIKHIRVTNTSNGGY 491

Query: 65  SAETAPGVHKRFFRKVKNLISA 86
               A G  K  F  + +LI A
Sbjct: 492 ----ALGKSKEEFESIWDLIEA 509


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score = 43.9 bits (102), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 19/58 (32%), Positives = 36/58 (62%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           Y G+ISR+  E++L+     G++L+R+SES PG + + V Y   +  ++V +  +G +
Sbjct: 61  YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKY 118


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score = 43.9 bits (102), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 15/118 (12%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG---------YIYTYRVS 57
           Y   ++R   ++LL+  G +G++++RDS  + GVY + V  +           +  Y++ 
Sbjct: 214 YSKNMNRMQAQELLMREGKEGAFMVRDSSHM-GVYTVSVFTKAPSQSGEKNPKVKHYQIR 272

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV--EKSSGRGPQAP 113
           QTETG+     A       F  +  LI   Q    G++T L++PV  + SS +   AP
Sbjct: 273 QTETGAGPFYLAENY---LFNTIPELIHYHQHNAAGLITRLRHPVSPDGSSAQQVSAP 327


>UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS
          Length = 938

 Score = 43.9 bits (102), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/102 (25%), Positives = 51/102 (50%), Gaps = 3/102 (2%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           D +  +H  +SRE  + LL     DG++L+R+S +  G + L +L Q  +  Y+V +  E
Sbjct: 5   DHMKWFHANLSREAADDLLRQGYEDGTFLVRESSTAAGDFVLSILCQEEVCHYQVRRHGE 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
              +S +    +  +    ++ L+  +Q+   G+ T L  P+
Sbjct: 65  DAFFSIDDE--MQTKILHGLETLVDYYQQGANGLPTKLTVPL 104


>UniRef50_A9V2L8 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2L8_MONBE
          Length = 877

 Score = 43.9 bits (102), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 14/106 (13%)

Query: 8   HGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG---- 62
           HG+ISRE  E LL   G  DG +L+R S SVPG + L + ++  I  + +    T     
Sbjct: 304 HGEISREVAEALLKQQGAADGLFLVRRSTSVPGAFVLSLCHRDDILHHIIYAGHTCYQIF 363

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
              A+T  G        + + +S FQ P  G +TPL   V +++  
Sbjct: 364 DIEADTLEG--------LIHFLSDFQ-PQHGWLTPLNMHVPRAASE 400


>UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_SCHMA
          Length = 1264

 Score = 43.5 bits (101), Expect = 0.002,   Method: Composition-based stats.
 Identities = 35/121 (28%), Positives = 58/121 (47%), Gaps = 8/121 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++   ++GKI+RE  E+LL   G  +G +LLR  ESV   Y + + + G ++ Y V +  
Sbjct: 45  ESTNYFYGKITREQAEELLFTNGANEGLFLLR--ESVNRNYAVSICHLGRVHHYNVERHT 102

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
             S+  +T    HK F   V+ L+        G +T  Q P+ +  G  P    G   +D
Sbjct: 103 DCSYRIQTG---HK-FIGPVE-LVQHHSTQLDGFLTLAQLPLNRPVGMSPIVLQGLNAND 157

Query: 121 I 121
           +
Sbjct: 158 L 158


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score = 43.5 bits (101), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/126 (26%), Positives = 56/126 (44%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGY----IYTYR 55
           M+    +   ISR    + L+A G   GS+L+R+SE+ PG Y L +         +  YR
Sbjct: 111 METEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFDNNGDGVKHYR 170

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           +   + G +   T     K  F  +K L+  + +   G+ T L  P +    + PQ P  
Sbjct: 171 IRNMDNGGFYITT-----KISFNSLKELVQHYSRDSDGLCTKLVKPCQ---SKAPQKPWW 222

Query: 116 RRDSDI 121
           + + +I
Sbjct: 223 QDEWEI 228


>UniRef50_UPI000192628F PREDICTED: similar to chimerin (chimaerin) 1, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI000192628F
          Length = 444

 Score = 43.5 bits (101), Expect = 0.002,   Method: Composition-based stats.
 Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 2/50 (4%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
           +HG ISRE  EKL++    +G YL R+SE +PG Y L   +      YR+
Sbjct: 81  FHGAISREEAEKLVMKD--EGCYLTRESERLPGTYALTFRFNNAPKNYRL 128


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score = 43.5 bits (101), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 6/101 (5%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           + G+ISR     +L  T  +G +L+R+SE+ PG Y L + +   +  YR+   E   +  
Sbjct: 346 FRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEGVRHYRIQHIEGQYFVN 405

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
           E     H+  F  +  LI   +    GIVT L+  +  ++ 
Sbjct: 406 EN----HR--FDSIPQLIEYHKLNGGGIVTRLRRAINDANA 440


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score = 43.5 bits (101), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 6/102 (5%)

Query: 1   MDAVTVYHGKISR-ETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   Y GKI R E  +KLLL     G++L+RDSES    + L V     +  YR+ Q 
Sbjct: 142 IEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFSLSVRDGDTVKHYRIRQL 201

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           + G +         +  FR ++ L+  +     G+   L+ P
Sbjct: 202 DEGGFFI-----ARRTTFRTLQELVDHYGNEADGLCVNLRKP 238


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score = 43.5 bits (101), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 9/113 (7%)

Query: 1   MDAVTVYHGKISR-ETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   Y  KI R E  +KLLL     G++L+RDSES    Y L V     +  YR+ Q 
Sbjct: 125 IEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQL 184

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP---VEKSSGRG 109
           + G +         +  FR ++ L+  + K   G+   L  P   +EK    G
Sbjct: 185 DEGGFFI-----ARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEG 232


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 10/109 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSES----VPGVYCLCVLYQGYIYTYR 55
           ++A   Y G I R   EKLL+  G  DGS+L+R SE+    V   + L V  +  I  YR
Sbjct: 124 LEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVRDKELIRHYR 183

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +  T++G +    +     + F  +  LI  ++    G+   L  P  K
Sbjct: 184 IKITDSGKYFISLS-----KEFSTLNELIEFYKISSDGLKIKLLEPCRK 227


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 1/51 (1%)

Query: 7   YHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
           +HG+I RE   K+++  G +DG +LLRDS+S P  + L + +   I  +++
Sbjct: 508 FHGRIVREEAHKMIIQQGQVDGLFLLRDSQSNPRAFVLTLCHHQKIKHFQI 558


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 23/51 (45%), Positives = 30/51 (58%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS 57
           YHG + R++ E  L A    GSYL+R+SE  PG Y L  L Q  I  +RV+
Sbjct: 69  YHGCLDRQSAELRLNAADKPGSYLVRESERKPGSYVLSYLGQRGINHFRVT 119


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVP--GVYCLCVLYQGYIYTYRV 56
           Y GKISR+  E+ L++   DG++++RDSES P  G + L V ++  +  +++
Sbjct: 63  YVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKI 114


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 21/43 (48%), Positives = 28/43 (65%), Gaps = 3/43 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG 49
           YHG++SR   EKLL A   DG +L+RDS + PG Y L  ++ G
Sbjct: 479 YHGRMSRRAAEKLLRA---DGDFLVRDSVTNPGQYVLTGMHAG 518


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score = 42.7 bits (99), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 18/39 (46%), Positives = 28/39 (71%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
           +HG +S +  EKL+L  G +GS+L+R+S+S PG + L V
Sbjct: 112 FHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSV 150


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 42.7 bits (99), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 19/39 (48%), Positives = 27/39 (69%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
           YHG I  +  E++LL+ G  GSYL+R+S+S PG + L V
Sbjct: 112 YHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVLVV 150


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score = 42.7 bits (99), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 20/55 (36%), Positives = 31/55 (56%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           Y+GK++R   E  L   G +G +L+RDSES P  + + +  QG    ++V   ET
Sbjct: 86  YYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKET 140


>UniRef50_Q5C0L2 SJCHGC05893 protein (Fragment) n=1 Tax=Schistosoma japonicum
          RepID=Q5C0L2_SCHJA
          Length = 301

 Score = 42.4 bits (98), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 1/50 (2%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          YHG ISR+  E+LL +   DGSYL+RDS+     Y L + +      +++
Sbjct: 45 YHGPISRQETEELL-SNAQDGSYLIRDSQRAENAYTLVIWFDKMAKNFKL 93


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score = 42.4 bits (98), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 19/58 (32%), Positives = 33/58 (56%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + GKI R   E++L     DG++L+R+SES PG + L V +   +  ++V +   G +
Sbjct: 61  FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKY 118


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score = 42.4 bits (98), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 31/110 (28%), Positives = 48/110 (43%), Gaps = 12/110 (10%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY------QGYIYTYRVSQTE 60
           Y   ++R   E+LL   G +G +++RDS S  G Y + V        QG I  Y V  T 
Sbjct: 282 YSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTP 340

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
              +         K  F  +  LI+  Q    G+++ L+YPV + +   P
Sbjct: 341 QSQYYL-----AEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAP 385


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score = 42.4 bits (98), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 19/58 (32%), Positives = 33/58 (56%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + GKI R   E++L     DG++L+R+SES PG + L V +   +  ++V +   G +
Sbjct: 61  FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKY 118


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score = 42.4 bits (98), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 6/96 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           Y GK+SR   +  L    LDG++L+R+SE+  G Y L V + G    YR+ Q +   +  
Sbjct: 259 YVGKMSRVEAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYRI-QHDGNEYYI 317

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
            T    H++  + +K LI   +    G+ T L+ P 
Sbjct: 318 TTR---HRQ--KTIKELIDYHKLNGGGLCTRLKKPA 348


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score = 42.4 bits (98), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 19/40 (47%), Positives = 27/40 (67%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL 46
           YHG ++ +  EKLL   G  GS+L+R+S+S PG + L VL
Sbjct: 111 YHGHLTGKEAEKLLTEKGKPGSFLVRESQSKPGDFVLSVL 150


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score = 42.0 bits (97), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 3/52 (5%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +HG ISRE  EKL+     +G +L+RDS S PG + L V ++G    + V++
Sbjct: 127 FHGGISREKAEKLIRE---NGDFLVRDSISKPGNFVLTVRWKGVSMHFVVNK 175


>UniRef50_UPI000180D0F7 PREDICTED: similar to dual adaptor of phosphotyrosine and
           3-phosphoinositides n=1 Tax=Ciona intestinalis
           RepID=UPI000180D0F7
          Length = 254

 Score = 42.0 bits (97), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 23/113 (20%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG I+R   E LL+A G +GS+L+RD   V G  C+ V     +  +++  T      A
Sbjct: 11  YHGGITRHVAEALLMANGREGSFLMRD---VTGGQCISVRTNDAVKHFKIEVT------A 61

Query: 67  ETAPGVHKRFFRKVKNLISAF--------------QKPDQGIVTPLQYPVEKS 105
           +         F  + +L+  F              +  D G +  L+YP  KS
Sbjct: 62  DAEVVFAHGSFMSMAHLLQVFANQLILCADLGSLSKNFDHGTMLILKYPYPKS 114


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score = 42.0 bits (97), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 17/39 (43%), Positives = 28/39 (71%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
          +HG +S +  E+L+L  G +GS+L+R+S+S PG + L V
Sbjct: 59 FHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSV 97


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
          RepID=UPI00016E7A57
          Length = 668

 Score = 42.0 bits (97), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 3/50 (6%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          YHG + RE GE LL     DG +L+RDS S PG Y L   +      +++
Sbjct: 25 YHGPLGREAGEALL---ERDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKI 71


>UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain-containing adapter
           protein APS) (Adapter protein with pleckstrin homology
           and Src homology 2 domains). n=3 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A1A97
          Length = 591

 Score = 42.0 bits (97), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 22/58 (37%), Positives = 33/58 (56%), Gaps = 2/58 (3%)

Query: 7   YHGKISRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           +HG +SR    +L+L+ G    G +++R SE+ PG Y L   +QG     R+S  ETG
Sbjct: 464 FHGTLSRIRAAQLVLSGGTRSHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNETG 521


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score = 41.6 bits (96), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 11/96 (11%)

Query: 11  ISRETGEKLLLATGLDGSYLLRDSESV----PGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           I+R   E+LL   G +GS+L+R+S  V      VY  C+  +  +  Y V Q  TG W  
Sbjct: 266 ITRAKAEQLLRQAGSEGSFLVRESSQVGKLTVSVYS-CIPCE-VVKHYHVKQLPTGEWYL 323

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
                  K  F  + +LI   Q    G+VT L++PV
Sbjct: 324 -----AEKHTFSTISDLIHYHQHNAAGLVTRLRHPV 354


>UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=Euteleostomi
           RepID=Q5SUW3_MOUSE
          Length = 550

 Score = 41.6 bits (96), Expect = 0.007,   Method: Composition-based stats.
 Identities = 20/55 (36%), Positives = 33/55 (60%), Gaps = 1/55 (1%)

Query: 7   YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +HG+ISRE   +++   GL DG +LLRDS+S P  + L + +   I  +++   E
Sbjct: 450 FHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 504


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score = 41.6 bits (96), Expect = 0.008,   Method: Composition-based stats.
 Identities = 17/54 (31%), Positives = 36/54 (66%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +HG+I+R+  EK+L   G  G +L+R+SE++PG + + V     +  ++V++++
Sbjct: 292 FHGRITRQDSEKILGCPGESGLFLIRESETMPGDFAVSVKAPERVKHFKVTRSD 345


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score = 41.6 bits (96), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 31/127 (24%), Positives = 57/127 (44%), Gaps = 14/127 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCV-----LYQGYIYTY 54
           M+    ++  +SR    + LLA G   GS+L+R+SE+ PG + + V     +    I  Y
Sbjct: 115 METEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHY 174

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           R+   + G +        +K  F  +  L+  + +   G+ T L  P +    R PQ P 
Sbjct: 175 RIRNMDAGGFYI-----TNKISFNSLSELVKHYSREADGLCTRLVKPCQT---RAPQKPW 226

Query: 115 GRRDSDI 121
            + + ++
Sbjct: 227 WQDEWEV 233


>UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein activator 1 n=1 Tax=Ciona
           intestinalis RepID=UPI000052352E
          Length = 936

 Score = 41.2 bits (95), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 19/48 (39%), Positives = 27/48 (56%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTY 54
           YHGK+ R   E+ LL   + G YL+R+S+  PG Y L  L +    T+
Sbjct: 59  YHGKLDRRIAEERLLEVNVAGGYLVRESQKKPGSYVLSFLSENIGMTH 106


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score = 41.2 bits (95), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 19/48 (39%), Positives = 27/48 (56%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTY 54
           YHGK+ R   E+ L   G  GSYL+R+S+  PG + L  L Q  +  +
Sbjct: 182 YHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNH 229



 Score = 38.1 bits (87), Expect = 0.089,   Method: Compositional matrix adjust.
 Identities = 21/83 (25%), Positives = 41/83 (49%), Gaps = 6/83 (7%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HGKIS++    LL+  G   S+L+R S++ PG Y L       I  +++  T    +  
Sbjct: 352 FHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM- 410

Query: 67  ETAPGVHKRFFRKVKNLISAFQK 89
                +  R++  + ++I  ++K
Sbjct: 411 -----MGGRYYNSIGDIIDHYRK 428


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score = 41.2 bits (95), Expect = 0.011,   Method: Composition-based stats.
 Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 12/107 (11%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG +SR   E LL     DG YL+R+SES PG + L +     I  +++          
Sbjct: 281 YHGTLSRSECEFLLNEHAKDGEYLIRNSESKPGDFSLSMKAPNRIKHFKI-------LYG 333

Query: 67  ETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSSGR 108
                + +R F  +  L+S ++       + G    L YP+ KS  R
Sbjct: 334 NNQYVIGQRSFSNIDELLSHYKNYPIYTTENGQKMHLLYPLNKSFTR 380


>UniRef50_C4QAI3 Chimerin-related rho-gtpase-activating protein n=1
          Tax=Schistosoma mansoni RepID=C4QAI3_SCHMA
          Length = 798

 Score = 41.2 bits (95), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 1/50 (2%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          YHG ISR+  E+LL +   DGSYL+RDS+     Y L + +      +++
Sbjct: 45 YHGPISRQETEELL-SNADDGSYLIRDSQRAENAYTLVIWFDKVAKNFKL 93


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score = 41.2 bits (95), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 16/39 (41%), Positives = 27/39 (69%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
           Y+GK++R   E +L   G+DG +L+RDSES+P  + + +
Sbjct: 237 YYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISL 275


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score = 41.2 bits (95), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 3/43 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG 49
           YHG++SR   E++L A   DG +L+RDS + PG Y L  ++ G
Sbjct: 488 YHGRMSRRAAERMLRA---DGDFLVRDSVTNPGQYVLTGMHAG 527


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score = 40.4 bits (93), Expect = 0.016,   Method: Compositional matrix adjust.
 Identities = 18/39 (46%), Positives = 26/39 (66%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
           +HG +S    EKLL   G +GS+L+R+S+S PG + L V
Sbjct: 113 FHGHLSGREAEKLLTEKGKNGSFLVRESQSHPGDFVLSV 151



 Score = 40.0 bits (92), Expect = 0.021,   Method: Compositional matrix adjust.
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
          +H  I+    E LLL  G+DGS+L R S+S PG + L V   G +   ++  T
Sbjct: 7  FHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNT 59


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score = 40.4 bits (93), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 18/39 (46%), Positives = 26/39 (66%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
           +HG +S +  EKLL   G  GS+L+R+S+S PG + L V
Sbjct: 113 FHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSV 151



 Score = 40.4 bits (93), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 20/53 (37%), Positives = 29/53 (54%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
          +H  I+    E LLL  G+DGS+L R S+S PG + L V   G +   ++  T
Sbjct: 7  FHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNT 59


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score = 40.4 bits (93), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 15/121 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY-------IYT 53
           +D    Y   ++R   E+LL +   +G +++RDS S PG+Y +  LY  +          
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVS-LYTKFGGEGSSGFRH 299

Query: 54  YRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP 113
           Y + +T T   S +      K  F  +  +I   +    G+VT L+YPV   S +G  AP
Sbjct: 300 YHIKETTT---SPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV---SVKGKNAP 353

Query: 114 T 114
           T
Sbjct: 354 T 354


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score = 40.4 bits (93), Expect = 0.018,   Method: Compositional matrix adjust.
 Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 7/110 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HGKIS +   + L     DG +L+R+S   PG Y LCV +   +  YRV   + G  + 
Sbjct: 123 FHGKISGQEAVQQLQPPE-DGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRD-GHLTI 180

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
           + A      FF  + +++  + K    I T L  P  K   +  +    R
Sbjct: 181 DEAV-----FFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELAR 225


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score = 40.0 bits (92), Expect = 0.022,   Method: Compositional matrix adjust.
 Identities = 30/96 (31%), Positives = 47/96 (48%), Gaps = 6/96 (6%)

Query: 7   YHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           Y   +SR   ++LLL+   + G++L+R SES  G Y L V  Q  +  YRVS    GS  
Sbjct: 121 YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY 180

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
            +       R F  ++ L++ ++   + I  PL  P
Sbjct: 181 LQKG-----RLFPGLEELLTYYKANWKLIQNPLLQP 211


>UniRef50_Q1KL02 Chimerin 2 n=3 Tax=Tetraodontidae RepID=Q1KL02_TAKRU
          Length = 676

 Score = 39.7 bits (91), Expect = 0.033,   Method: Compositional matrix adjust.
 Identities = 20/51 (39%), Positives = 34/51 (66%), Gaps = 2/51 (3%)

Query: 6  VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV 56
          ++HG+ISRE  ++LL AT  +G+YL+R+S+  PG + L + +      YR+
Sbjct: 6  LFHGRISREYADELL-ATA-EGAYLIRESQRQPGSHTLALRFGHQTLNYRL 54


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score = 39.7 bits (91), Expect = 0.033,   Method: Compositional matrix adjust.
 Identities = 20/51 (39%), Positives = 30/51 (58%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS 57
           YHG++ R T E+ L      GSYL+R+S+  PG Y L  L +  I  +R++
Sbjct: 78  YHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRIT 128


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score = 39.3 bits (90), Expect = 0.035,   Method: Composition-based stats.
 Identities = 20/33 (60%), Positives = 24/33 (72%), Gaps = 1/33 (3%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPG 39
           Y G+ISRE  E LLL  G +G +L+RDSES PG
Sbjct: 302 YFGRISRERAEDLLLH-GREGEFLVRDSESNPG 333


>UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347924 n=1 Tax=Homo sapiens
           RepID=UPI0001A5EB2D
          Length = 475

 Score = 39.3 bits (90), Expect = 0.040,   Method: Composition-based stats.
 Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 3/43 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG 49
           YHG++SR   E++L A   DG +L+RDS + PG Y L  ++ G
Sbjct: 381 YHGRMSRRAAERMLRA---DGDFLVRDSVTNPGQYVLTGMHAG 420


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score = 39.3 bits (90), Expect = 0.041,   Method: Compositional matrix adjust.
 Identities = 20/43 (46%), Positives = 27/43 (62%), Gaps = 3/43 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG 49
           YHGK+SR+  E LL+    DG +L+R+S + PG Y L  L  G
Sbjct: 527 YHGKLSRKAAESLLVK---DGDFLVRESATSPGQYVLSGLQGG 566


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score = 39.3 bits (90), Expect = 0.043,   Method: Compositional matrix adjust.
 Identities = 18/58 (31%), Positives = 30/58 (51%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           YHG I+++    LL+  G   S+L+R S++ PG Y L       I  +++S T    +
Sbjct: 360 YHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRTNDIIQRFKISPTSNNQY 417


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score = 38.9 bits (89), Expect = 0.046,   Method: Compositional matrix adjust.
 Identities = 29/116 (25%), Positives = 52/116 (44%), Gaps = 11/116 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           M+    ++  I+R+  E+ LLA     GSYL+R+SE+  G Y L +       Q  +  Y
Sbjct: 122 METEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHY 181

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           ++   + G +    +P +    F  + ++I  + K   G+   L    EK   + P
Sbjct: 182 KIRSLDNGGYY--ISPKIT---FSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKP 232


>UniRef50_UPI0000E48B80 PREDICTED: hypothetical protein n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E48B80
          Length = 936

 Score = 38.9 bits (89), Expect = 0.048,   Method: Compositional matrix adjust.
 Identities = 19/54 (35%), Positives = 30/54 (55%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           Y+G++ R+  E L+L+ G    YL+RDS    G   L VLY   ++ Y +  T+
Sbjct: 837 YYGRMLRQECEYLMLSQGKSKQYLVRDSSHRAGDLMLSVLYGSKVHHYVIQTTD 890


>UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X6G9_CULQU
          Length = 109

 Score = 38.9 bits (89), Expect = 0.051,   Method: Compositional matrix adjust.
 Identities = 19/39 (48%), Positives = 23/39 (58%)

Query: 7  YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
          +H  +S    EKLLL  G DGS+L R S S PG + L V
Sbjct: 5  FHPSVSGVDAEKLLLERGFDGSFLARLSSSNPGAFTLSV 43


>UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00004D6B5A
          Length = 321

 Score = 38.9 bits (89), Expect = 0.051,   Method: Compositional matrix adjust.
 Identities = 27/84 (32%), Positives = 43/84 (51%), Gaps = 8/84 (9%)

Query: 7   YHGKISRETGEKLLLATGLDGS--YLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           +HG ISR    +L+ + G++G   +L+R SE+  G Y L   +QG     R++ TE G  
Sbjct: 224 FHGPISRVKAAQLVQSQGVEGHGVFLVRQSETRRGEYVLTFNFQGRAKHLRLTLTERGQC 283

Query: 65  SAETAPGVHKRFFRKVKNLISAFQ 88
             +     H R FR V  ++  F+
Sbjct: 284 HVQ-----HLR-FRSVLEMLQYFR 301


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score = 38.9 bits (89), Expect = 0.052,   Method: Compositional matrix adjust.
 Identities = 20/43 (46%), Positives = 27/43 (62%), Gaps = 3/43 (6%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG 49
           YHGK+SR+  E LL+    DG +L+R+S + PG Y L  L  G
Sbjct: 284 YHGKLSRKAAESLLVK---DGDFLVRESATSPGQYVLSGLQGG 323


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score = 38.5 bits (88), Expect = 0.059,   Method: Compositional matrix adjust.
 Identities = 17/39 (43%), Positives = 25/39 (64%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV 45
           +H  +S    E+LLLA G  G+YL+R+S S PG + + V
Sbjct: 141 FHAGLSGPEAERLLLAEGKHGTYLVRESHSSPGQFAISV 179


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score = 38.1 bits (87), Expect = 0.083,   Method: Compositional matrix adjust.
 Identities = 27/114 (23%), Positives = 53/114 (46%), Gaps = 11/114 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCV-----LYQGYIYTY 54
           + A   Y GK+ R+  E+ LL+ G   G++L+R+SE+  G Y L +     +   ++  Y
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
           ++ + + G +   T     +  F  ++ L+  + +   G+   L  P  K   R
Sbjct: 204 KIRKLDNGGYYITT-----RAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPR 252


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_O88890 SH2 domain-containing protein 1A n=11 Tax=Eutele...   193   1e-48
UniRef50_O60880 SH2 domain-containing protein 1A n=36 Tax=root R...   174   9e-43
UniRef50_UPI0000F2E785 PREDICTED: hypothetical protein n=1 Tax=M...   158   6e-38
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   147   9e-35
UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   146   2e-34
UniRef50_UPI00003A9BD4 PREDICTED: similar to SH2 domain-containi...   146   2e-34
UniRef50_UPI00016E9D38 UPI00016E9D38 related cluster n=1 Tax=Tak...   144   9e-34
UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun seq...   143   2e-33
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   142   3e-33
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          142   3e-33
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   142   4e-33
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          141   5e-33
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   141   6e-33
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   141   7e-33
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   140   1e-32
UniRef50_UPI0000EAFFB4 SH2 domain-containing protein 1B (EWS/FLI...   140   1e-32
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   140   2e-32
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   139   3e-32
UniRef50_O14796 SH2 domain-containing protein 1B n=17 Tax=Theria...   139   3e-32
UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosph...   139   4e-32
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   138   4e-32
UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   138   8e-32
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   137   1e-31
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   137   1e-31
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   136   2e-31
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   135   3e-31
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   135   3e-31
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   135   4e-31
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   133   2e-30
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   133   2e-30
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   132   3e-30
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   131   5e-30
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   131   5e-30
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   130   1e-29
UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tet...   129   2e-29
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   129   2e-29
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   129   2e-29
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...   129   2e-29
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   129   3e-29
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   128   5e-29
UniRef50_O15357 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   128   5e-29
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   128   5e-29
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   128   6e-29
UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa ...   127   9e-29
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   127   1e-28
UniRef50_C1BZH2 SH2 domain-containing protein 1A n=3 Tax=Euteleo...   127   1e-28
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   127   1e-28
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...   127   1e-28
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   126   2e-28
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN         126   3e-28
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   126   3e-28
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   125   4e-28
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   125   5e-28
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   124   6e-28
UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=...   124   1e-27
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...   123   1e-27
UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostom...   123   2e-27
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...   122   3e-27
UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS         122   3e-27
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   122   4e-27
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   121   1e-26
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...   120   1e-26
UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichop...   119   2e-26
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   119   3e-26
UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine ki...   118   8e-26
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...   117   1e-25
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...   117   1e-25
UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepI...   116   3e-25
UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_S...   115   3e-25
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...   113   1e-24
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   113   2e-24
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...   111   9e-24
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...   110   1e-23
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   108   5e-23
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE        107   1e-22
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...   104   6e-22
UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound p...   104   8e-22
UniRef50_A9V255 Predicted protein n=1 Tax=Monosiga brevicollis R...   101   8e-21
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI         100   1e-20
UniRef50_UPI000180D2FE PREDICTED: similar to SYK n=1 Tax=Ciona i...   100   2e-20
UniRef50_C4Q4M0 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   100   3e-20
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...    99   4e-20
UniRef50_A9V2L8 Predicted protein n=1 Tax=Monosiga brevicollis R...    99   4e-20
UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax...    96   3e-19
UniRef50_UPI0000E1FA37 PREDICTED: similar to signaling inositol ...    95   5e-19
UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n...    94   1e-18
UniRef50_C4QKJ6 Proto-oncogene tyrosine-protein kinase abl1, put...    90   3e-17
UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis R...    88   6e-17
UniRef50_UPI0001760433 PREDICTED: similar to beta chimerin n=1 T...    81   1e-14
UniRef50_A8PJS1 RhoGAP domain containing protein n=5 Tax=Chromad...    80   3e-14

Sequences not found previously or not previously below threshold:

UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   127   9e-29
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   123   1e-27
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   123   2e-27
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   116   3e-25
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   115   5e-25
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   114   7e-25
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   114   1e-24
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   112   4e-24
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   111   6e-24
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   111   7e-24
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   111   9e-24
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   110   1e-23
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   108   7e-23
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   106   2e-22
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   106   3e-22
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   105   4e-22
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   105   4e-22
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   105   4e-22
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...   105   6e-22
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   104   7e-22
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   104   1e-21
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   103   2e-21
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   103   2e-21
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   103   3e-21
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   101   9e-21
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...    99   2e-20
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...    99   2e-20
UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_...    99   4e-20
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...    99   5e-20
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...    98   6e-20
UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=...    98   8e-20
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...    97   2e-19
UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q...    97   2e-19
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...    96   2e-19
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...    96   2e-19
UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleos...    96   4e-19
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...    96   4e-19
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...    96   4e-19
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...    95   5e-19
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...    95   5e-19
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...    95   6e-19
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...    95   7e-19
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...    95   8e-19
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...    95   9e-19
UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A...    94   1e-18
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...    94   1e-18
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...    94   1e-18
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...    94   1e-18
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    93   2e-18
UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun se...    93   2e-18
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...    93   2e-18
UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra...    93   2e-18
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...    93   3e-18
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...    92   5e-18
UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichop...    92   5e-18
UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 ...    92   6e-18
UniRef50_UPI000180B667 PREDICTED: similar to GF12762 n=1 Tax=Cio...    91   7e-18
UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=...    91   7e-18
UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    91   1e-17
UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2...    91   1e-17
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...    91   1e-17
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...    90   2e-17
UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluvia...    90   2e-17
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...    90   3e-17
UniRef50_B7QCJ2 Growth factor receptor-bound protein, putative n...    90   3e-17
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...    90   3e-17
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS          89   4e-17
UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Tak...    89   4e-17
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...    88   6e-17
UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_D...    88   6e-17
UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (...    88   6e-17
UniRef50_Q29CU6 GA13993 n=10 Tax=Neoptera RepID=Q29CU6_DROPS           88   7e-17
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    88   7e-17
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...    88   9e-17
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...    88   9e-17
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...    88   9e-17
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...    88   1e-16
UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X...    88   1e-16
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...    87   1e-16
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...    87   1e-16
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...    87   2e-16
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...    87   2e-16
UniRef50_A7S295 Predicted protein n=1 Tax=Nematostella vectensis...    87   2e-16
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...    86   2e-16
UniRef50_UPI000180BA50 PREDICTED: similar to growth factor recep...    86   3e-16
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...    86   3e-16
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...    86   3e-16
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...    86   3e-16
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...    86   3e-16
UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus...    86   4e-16
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE      86   4e-16
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...    86   5e-16
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...    85   6e-16
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...    85   6e-16
UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine ph...    85   6e-16
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...    85   6e-16
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    84   1e-15
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...    84   1e-15
UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    84   1e-15
UniRef50_Q9XYM0 Adapter molecule Crk n=8 Tax=Endopterygota RepID...    84   2e-15
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...    84   2e-15
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...    84   2e-15
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...    83   2e-15
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...    83   3e-15
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...    83   3e-15
UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n...    83   3e-15
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...    83   3e-15
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...    82   4e-15
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...    82   4e-15
UniRef50_UPI000180D0F7 PREDICTED: similar to dual adaptor of pho...    82   5e-15
UniRef50_A8Q2Q3 SH2 domain containing protein n=1 Tax=Brugia mal...    81   7e-15
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...    81   7e-15
UniRef50_A9USN6 Predicted protein n=1 Tax=Monosiga brevicollis R...    81   7e-15
UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome ...    81   8e-15
UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY3...    81   8e-15
UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...    81   9e-15
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    81   9e-15
UniRef50_UPI000192628F PREDICTED: similar to chimerin (chimaerin...    81   1e-14
UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tet...    81   1e-14
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...    81   1e-14
UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi s...    81   1e-14
UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixo...    81   1e-14
UniRef50_Q1LWW1 Novel protein similar to vertebrate phospholipas...    81   1e-14
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...    81   1e-14
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...    80   2e-14
UniRef50_B7Q2R0 Adaptor protein Crk, putative (Fragment) n=1 Tax...    80   2e-14
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...    80   2e-14
UniRef50_UPI0000E460CB PREDICTED: similar to V-crk sarcoma virus...    80   2e-14
UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome ...    80   3e-14
UniRef50_UPI0001925DBD PREDICTED: similar to Dual adaptor of pho...    80   3e-14
UniRef50_Q4SKC0 Chromosome 13 SCAF14566, whole genome shotgun se...    80   3e-14
UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis...    80   3e-14
UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein act...    80   3e-14
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...    80   3e-14
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...    80   3e-14
UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=T...    79   4e-14
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...    79   4e-14
UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homini...    79   4e-14
UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Br...    79   4e-14
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...    79   5e-14
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...    79   5e-14
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...    78   6e-14
UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis R...    78   9e-14
UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...    78   9e-14
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...    78   9e-14
UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis R...    78   1e-13
UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis...    78   1e-13
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...    78   1e-13
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...    78   1e-13
UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specif...    78   1e-13
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...    78   1e-13
UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n...    78   1e-13
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...    77   1e-13
UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=...    77   1e-13
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...    77   1e-13
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...    77   1e-13
UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=M...    77   2e-13
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...    77   2e-13
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...    77   2e-13
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...    77   2e-13

>UniRef50_O88890 SH2 domain-containing protein 1A n=11 Tax=Euteleostomi
           RepID=SH21A_MOUSE
          Length = 126

 Score =  193 bits (492), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 126/126 (100%), Positives = 126/126 (100%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE
Sbjct: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD
Sbjct: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120

Query: 121 ICLNAP 126
           ICLNAP
Sbjct: 121 ICLNAP 126


>UniRef50_O60880 SH2 domain-containing protein 1A n=36 Tax=root RepID=SH21A_HUMAN
          Length = 128

 Score =  174 bits (441), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 110/128 (85%), Positives = 115/128 (89%), Gaps = 2/128 (1%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MDAV VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY GYIYTYRVSQTE
Sbjct: 1   MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV-EKSSGRGPQAPTGRRDS 119
           TGSWSAETAPGVHKR+FRK+KNLISAFQKPDQGIV PLQYPV +KSS R  Q  TG R+ 
Sbjct: 61  TGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIRED 120

Query: 120 -DICLNAP 126
            D+CL AP
Sbjct: 121 PDVCLKAP 128


>UniRef50_UPI0000F2E785 PREDICTED: hypothetical protein n=1 Tax=Monodelphis domestica
           RepID=UPI0000F2E785
          Length = 197

 Score =  158 bits (399), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 95/105 (90%), Positives = 100/105 (95%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MD+V+VYHG ISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ+E
Sbjct: 1   MDSVSVYHGNISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQSE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           TGSWSAETAPGV KR FRK+KNLISAFQKPDQGIV PLQ+PVEK 
Sbjct: 61  TGSWSAETAPGVQKRLFRKIKNLISAFQKPDQGIVIPLQHPVEKK 105


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  147 bits (372), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 37/106 (34%), Positives = 58/106 (54%), Gaps = 7/106 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  +HGKISRE  E LL+    DG +L+R+S   PG Y LCV +Q  +  YR+ Q + G 
Sbjct: 99  MPWFHGKISRELAESLLMPR-EDGLFLVRESAHFPGDYTLCVCFQDQVDHYRM-QGKNGK 156

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
            + +      + +F  ++ L+  ++K   G+ T L+ PV K  GR 
Sbjct: 157 LTID-----EEVYFSSLEELVQHYEKDADGLCTRLRKPVVKQGGRE 197


>UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2B n=7
           Tax=Clupeocephala RepID=SHP2B_DANRE
          Length = 1226

 Score =  146 bits (370), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 47/118 (39%), Positives = 70/118 (59%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YH  ISR   E+LL   G+DGS+L+RDSESVPG Y LC+L+Q +++TYR+    
Sbjct: 1   MTGAPWYHRDISRVRAEELLAHAGIDGSFLVRDSESVPGAYALCLLFQRHVHTYRILPDA 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            G  + +   GV    FR + +L+  +Q P++G+V PL YPV + S    ++  G  +
Sbjct: 61  DGLLAVQATQGVQVNCFRTLGDLVLGYQNPNKGLVAPLLYPVMRESEANDESSDGDDE 118


>UniRef50_UPI00003A9BD4 PREDICTED: similar to SH2 domain-containing molecule EAT2 n=2
           Tax=Neognathae RepID=UPI00003A9BD4
          Length = 134

 Score =  146 bits (369), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 54/116 (46%), Positives = 79/116 (68%), Gaps = 2/116 (1%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             +HGKISR+  E LL   G +GSYL+R+SE+V G  CLCVL++  IYTYR+ +   G +
Sbjct: 4   PFFHGKISRKACEDLLCKKGKNGSYLIRESETVAGALCLCVLFEKVIYTYRIFREYEGCY 63

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK--SSGRGPQAPTGRRD 118
             +T+ GV ++ F+ +K+LI  ++KP+QG+VT L+YPV+K  SS R  +  TG  D
Sbjct: 64  KVQTSEGVPQKVFKTLKDLIYNYEKPNQGLVTKLRYPVKKTSSSRRSQRFKTGNDD 119


>UniRef50_UPI00016E9D38 UPI00016E9D38 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9D38
          Length = 130

 Score =  144 bits (363), Expect = 9e-34,   Method: Composition-based stats.
 Identities = 66/121 (54%), Positives = 82/121 (67%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+ + VYHG I +E GE+ L   G DG YL+R+S+SVPGVYCLCVL  GY+YTYR+ Q  
Sbjct: 1   MENLPVYHGPIGKEEGERRLGQDGRDGCYLVRNSDSVPGVYCLCVLCHGYVYTYRLYQDH 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            GSW+A+T PGV KR FR ++NLI+AFQKP QGIV PL YPV        Q  T    + 
Sbjct: 61  GGSWAADTTPGVPKRSFRHIRNLIAAFQKPGQGIVMPLLYPVTAQIRARTQMKTQMSSNS 120

Query: 121 I 121
           +
Sbjct: 121 L 121


>UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RP74_TETNG
          Length = 968

 Score =  143 bits (361), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 47/122 (38%), Positives = 71/122 (58%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YH  ISR   E+LL   G DGSYL+RDSESVPG Y LC+L+Q +++TYR+    
Sbjct: 9   MATAVWYHRDISRVQAEELLARAGKDGSYLVRDSESVPGAYALCLLFQRHVHTYRILPDA 68

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G  + +T  GV    FR +++L+  +Q+P +G+V+PL Y V +    G ++    +   
Sbjct: 69  DGLLAVQTTQGVQVNCFRTLEDLVFGYQQPHKGLVSPLLYGVPRDMDIGDESSDDEKPPP 128

Query: 121 IC 122
           + 
Sbjct: 129 VS 130


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  142 bits (359), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y G +Y YR+S+  
Sbjct: 268 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDP 326

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP--DQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+     P    G++TPL YP  K +            
Sbjct: 327 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 381

Query: 118 DSDIC 122
           + +IC
Sbjct: 382 EWEIC 386


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  142 bits (358), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 248 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 306

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP--DQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+     P    G++TPL YP  K +            
Sbjct: 307 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 361

Query: 118 DSDIC 122
           + +IC
Sbjct: 362 EWEIC 366


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  142 bits (358), Expect = 4e-33,   Method: Composition-based stats.
 Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 249 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 307

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP--DQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+     P    G++TPL YP  K +            
Sbjct: 308 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 362

Query: 118 DSDIC 122
           + +IC
Sbjct: 363 EWEIC 367


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  141 bits (357), Expect = 5e-33,   Method: Composition-based stats.
 Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 257 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 315

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP--DQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+     P    G++TPL YP  K +            
Sbjct: 316 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 370

Query: 118 DSDIC 122
           + +IC
Sbjct: 371 EWEIC 375


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  141 bits (356), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HG+ISRE  EKLL     +G +L+R+S++ PG Y LCV Y G +  YRV + E
Sbjct: 104 LKTMPWFHGRISREDAEKLLTPP-KNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNE 162

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
            G  + +        +F  +  L+  +QK   G+ T L+ PV+K    
Sbjct: 163 KGLVTVDD-----DEYFDNLIKLVEHYQKEADGLCTRLKAPVDKEGQH 205


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  141 bits (356), Expect = 7e-33,   Method: Composition-based stats.
 Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y G +Y YR+S+  
Sbjct: 192 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDS 250

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ--KPDQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+          G++TPL YP  K +            
Sbjct: 251 DGKVYV-----TAEAKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 305

Query: 118 DSDIC 122
           + +IC
Sbjct: 306 EWEIC 310


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  140 bits (354), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 33/126 (26%), Positives = 56/126 (44%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLY----QGYIYTYR 55
           M+    +   ISR    + L+A G   GS+L+R+SE+ PG Y L +         +  YR
Sbjct: 111 METEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFDNNGDGVKHYR 170

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           +   + G +   T     K  F  +K L+  + +   G+ T L  P +    + PQ P  
Sbjct: 171 IRNMDNGGFYITT-----KISFNSLKELVQHYSRDSDGLCTKLVKPCQ---SKAPQKPWW 222

Query: 116 RRDSDI 121
           + + +I
Sbjct: 223 QDEWEI 228


>UniRef50_UPI0000EAFFB4 SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2)
           (EAT-2). n=2 Tax=Canis lupus familiaris
           RepID=UPI0000EAFFB4
          Length = 134

 Score =  140 bits (353), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 51/114 (44%), Positives = 73/114 (64%), Gaps = 4/114 (3%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  YHG +S++  E LLL  G+DG++LLRDSES+PGV CLCV ++  +YTYR+ +   G 
Sbjct: 3   LPYYHGPLSKKDCETLLLKDGIDGNFLLRDSESLPGVLCLCVSFKNLVYTYRIFEERRGF 62

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
           ++ +T  G  K  F  +K LIS F+KP QG+V  L  P++K+S      P  RR
Sbjct: 63  YNIQTVEGAPKEIFPNLKELISKFEKPSQGLVMHLIQPIKKASS----CPRWRR 112


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  140 bits (353), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 11/123 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 374 LEKHSWYHGPVSRNAAEHLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 432

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS-----GRGPQAPTG 115
            G           +  F  +  L+        G++T L YP  K +     G  P     
Sbjct: 433 DGKLYVS-----SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPSVYGVSPNYDKW 487

Query: 116 RRD 118
             +
Sbjct: 488 EME 490


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  139 bits (350), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 11/123 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 8   LEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 66

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS-----GRGPQAPTG 115
            G           +  F  +  L+        G++T L YP  K +     G  P     
Sbjct: 67  DGKLYVS-----SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKW 121

Query: 116 RRD 118
             +
Sbjct: 122 EME 124


>UniRef50_O14796 SH2 domain-containing protein 1B n=17 Tax=Theria RepID=SH21B_HUMAN
          Length = 132

 Score =  139 bits (350), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 47/103 (45%), Positives = 74/103 (71%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  YHG+++++  E LLL  G+DG++LLRDSES+PGV CLCV ++  +YTYR+ + + G 
Sbjct: 3   LPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGY 62

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           +  +TA G  K+ F  +K LIS F+KP+QG+V  L  P++++S
Sbjct: 63  YRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTS 105


>UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosphate 5- phosphatase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BC71
          Length = 1019

 Score =  139 bits (350), Expect = 4e-32,   Method: Composition-based stats.
 Identities = 44/118 (37%), Positives = 65/118 (55%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
             HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY   +YTYR+   +   ++
Sbjct: 5   WNHGNITRSKAEELLSKTGKDGSFLVRASESISRAYALCVLYHNCVYTYRILPNDDEKFT 64

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICL 123
            + + GV  RFF  ++ LI  ++K + G+VT LQYPV+         P    +  +  
Sbjct: 65  VQASEGVPMRFFTSLEQLIDFYKKENMGLVTHLQYPVQLEEEDAADDPEEETEFIMSP 122


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  138 bits (349), Expect = 4e-32,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 11/123 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 122 LEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS-----GRGPQAPTG 115
            G           +  F  +  L+        G++T L YP  K +     G  P     
Sbjct: 181 DGKLYVS-----SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235

Query: 116 RRD 118
             +
Sbjct: 236 EME 238


>UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 n=40
           Tax=Euteleostomi RepID=SHIP1_HUMAN
          Length = 1189

 Score =  138 bits (347), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 48/112 (42%), Positives = 68/112 (60%), Gaps = 3/112 (2%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
             HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY+  +YTYR+   E   ++
Sbjct: 5   WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE---KSSGRGPQAPT 114
            + + GV  RFF K+  LI  ++K + G+VT LQYPV    + +G  P+  T
Sbjct: 65  VQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDT 116


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  137 bits (345), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 38/123 (30%), Positives = 60/123 (48%), Gaps = 9/123 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G+DGS+L+RDSES PG   + + + G +Y YR+S   
Sbjct: 182 LEKHSWYHGPISRNAAEYLL-SSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGS 240

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV---EKSSGRGPQAPTGRR 117
            G     T     +  F  +  L+    K   G++T L+YP    +K    G        
Sbjct: 241 DGKVFVTT-----ESKFSTIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLPDEW 295

Query: 118 DSD 120
           + +
Sbjct: 296 EIE 298


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  137 bits (345), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 35/122 (28%), Positives = 59/122 (48%), Gaps = 12/122 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT- 59
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+++  
Sbjct: 169 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDT 227

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR-----GPQAPT 114
             G     T     +  F  +  L+        G++T L YP  K +        P+   
Sbjct: 228 SDGKVYVTT-----ESRFNTLAELVHHHSMHSDGLITQLLYPAPKHNKPTVFALSPEPDE 282

Query: 115 GR 116
             
Sbjct: 283 WE 284


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  136 bits (342), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 68/120 (56%), Gaps = 7/120 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D+   YHG+I R T E  L + G++GS+L+R+S+S  G + + +   G ++ YR+S+T+
Sbjct: 174 LDSEPYYHGRIPRTTAEFFL-SNGINGSFLVRESQSNAGEHTISLRCDGKVFHYRISRTD 232

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G + A        R F  V++L+  + +   G+V PL++ V K+      +P+ + + D
Sbjct: 233 KGVFIAAD------RVFSTVQDLVKFYHQQSDGLVHPLRHAVPKNRQEITASPSDKWEID 286


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  135 bits (341), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 7/116 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + A+  +HGKI+R   E LL     DG +L+R+S + PG Y +CV + G +  YRV   +
Sbjct: 103 LTAMPWFHGKITRSDAEDLLTPR-KDGLFLVRESTNYPGDYTMCVSFAGEVEHYRVIF-K 160

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
               + +      + +F  +  L+  +++   G+V  L  P+ K  G      T  
Sbjct: 161 DNKVTID-----EEEYFENLTKLVEHYERDADGLVCTLTQPLIKKGGHEYSVDTEE 211


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  135 bits (341), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 11/123 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 461 LEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 519

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS-----GRGPQAPTG 115
            G           +  F  +  L+        G++T L YP  K +     G  P     
Sbjct: 520 DGKLYVS-----SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 574

Query: 116 RRD 118
             +
Sbjct: 575 EME 577


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  135 bits (341), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 33/104 (31%), Positives = 54/104 (51%), Gaps = 6/104 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++ ++GS+L+R+SES PG   + + Y+G +Y YR++ T 
Sbjct: 168 LEKHSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            G           +  F  +  L+        G+VT L YP  K
Sbjct: 227 DGKVYV-----TAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 265


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  133 bits (335), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 6/122 (4%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     YHG+ISR   E+LL   G   GS+L+RDS +  G Y L + +QG  Y Y +S+ 
Sbjct: 4   LSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISRH 63

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
             GS + +         F     LI    K   G++T L+ P  +  G+ PQ        
Sbjct: 64  PDGSVAIQDGA-----KFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQGYRFISHE 118

Query: 120 DI 121
           ++
Sbjct: 119 EM 120



 Score = 93.8 bits (232), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 7/94 (7%)

Query: 6   VYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            +HG ISRE  E+ + A G  DG +L+R+   V   + LCV  +  IY Y +     G  
Sbjct: 163 WFHGAISREESEQRMKAFGLRDGLFLVRERTEVN-SFALCVAVKNDIYHYLLEMNTLGQL 221

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
           S E       R F  +  ++  + +   G++  L
Sbjct: 222 SIENG-----RKFENLLQVVDHYSRTPDGLLCTL 250


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  133 bits (335), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D  T YHGKISR   E +L  +G+ GS+L+R+SE+  G Y + V + G ++ YR++   
Sbjct: 189 LDKYTWYHGKISRSDSEAIL-GSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDN 247

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           T            +  FR +  L+        G++  L YP  K          GR    
Sbjct: 248 TEKMFI-----TQEVKFRTLGELVHHHSVHADGLICLLMYPASKK-------DKGRGLFS 295

Query: 121 ICLNAP 126
           +  NAP
Sbjct: 296 LSPNAP 301


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  132 bits (333), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 7/105 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG+I RE  E LL     DG +L+R+S + PG Y LCV +   +  YR+   E
Sbjct: 373 LNAMPWFHGRIKREEAENLLKPR-EDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKYAE 431

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
               + +        +F  +  L+  +     G+ T L   + K 
Sbjct: 432 N-KLTIDD-----DEYFDNLGQLVEHYTLDSDGLCTKLMKALPKE 470


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  131 bits (331), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 29/101 (28%), Positives = 48/101 (47%), Gaps = 7/101 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HGKI+RE  E+LL      G +L+R+S + PG Y LCV   G +  YR+    
Sbjct: 77  LSLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHA 135

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           +   S +      + +F  +  L+  +     G+ T L  P
Sbjct: 136 S-KLSID-----EEVYFENLMQLVEHYTSDADGLCTRLIKP 170


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  131 bits (331), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 7/104 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG I+R+  E LL     DG +L+R+S + PG Y LCV +Q  +  YRV   E
Sbjct: 474 LNAMPWFHGSITRDEAEHLLQPR-EDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 532

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
               + +      + +F  +  L++ ++    G+ T L   + K
Sbjct: 533 N-KLTIDD-----EEYFENLGQLVAHYEADADGLCTQLIKCLPK 570


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  130 bits (328), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 7/104 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG I+R+  E LL     DG +L+R+S + PG Y LCV +Q  +  YRV   E
Sbjct: 679 LNAMPWFHGSITRDEAEHLLQPR-EDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 737

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
               + +      + +F  +  L++ ++    G+ T L   + K
Sbjct: 738 N-KLTIDD-----EEYFENLGQLVAHYEADADGLCTQLIKCLPK 775


>UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4774
          Length = 132

 Score =  129 bits (326), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 40/101 (39%), Positives = 65/101 (64%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG I R+T E+LL     DG+YL+RDSE+VPG  CLCV     +YTYR+ +T +G +  
Sbjct: 5   YHGAIGRKTCEELLGKKNKDGAYLIRDSETVPGAMCLCVFKGRVVYTYRLLKTRSGDYML 64

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
             A G+ + +F+ +++LI  +++ DQG+   L++ V++   
Sbjct: 65  MVADGIEETYFKNLEDLIRHYKRRDQGLAMHLRHAVQRKIA 105


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  129 bits (326), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 9/109 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           +  +  + GKI+RE  E+LL    + G +L+R+S + PG Y LCV+       +  YRV 
Sbjct: 87  LHEMPWFFGKITREKAEELLTPREV-GLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 145

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
            T     + +      + FF  +  LI  ++K   G+ T L+ P++K +
Sbjct: 146 STSDNQVTVD-----EEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKT 189


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  129 bits (325), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 32/104 (30%), Positives = 54/104 (51%), Gaps = 6/104 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   YHG I R   E LL  +G+ GS+L+R+SES PG   + + Y+G I+ YR+ + +
Sbjct: 162 LESEKWYHGAIQRSYAEYLLN-SGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDD 220

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +  +       +    F  V +L+   +K   G+   L YP  K
Sbjct: 221 SNMYYV-----IESNKFTSVSDLVHHHEKHSDGLACTLLYPAPK 259


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score =  129 bits (325), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 39/112 (34%), Positives = 63/112 (56%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YHG+++R+  E+LLL+  +DGS+++R SES  G Y L VL+   ++TYR+  TE
Sbjct: 1   MSDEIWYHGRVNRQQSEELLLSAAVDGSFVVRASESRAGAYALSVLFNNSVHTYRILPTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
             + + +T  GV +R F+ +  L+  ++    G+V  L  PV   S   P  
Sbjct: 61  NNTLAVQTVNGVQQRKFKSLTELVHEYRNSQNGLVCGLSNPVGLDSKTRPST 112


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  129 bits (324), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 32/121 (26%), Positives = 55/121 (45%), Gaps = 7/121 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   +    S+     LL   G DG++L+R+SES PG Y L V YQG +  Y++   +
Sbjct: 277 LESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLSVFYQGKLKHYKIKHDQ 336

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT-GRRDS 119
                +E      +  F  +  LI   +    G+VT L+ PV+ ++          R + 
Sbjct: 337 DMYRVSE------RHTFASISELIEYHKHNGGGLVTRLRKPVQDANTPITAGLGHDRWEL 390

Query: 120 D 120
           D
Sbjct: 391 D 391


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  128 bits (323), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 11/117 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           + +  +HGKISRE  E++L   G DG +L+R+S S  G Y L VL++G +  Y + +  +
Sbjct: 5   ENLCWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGD 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
              +S      +H      + +LI  +QK    +VT LQ        R    P   R
Sbjct: 65  DAFFSIHDHTPIH-----GLDSLIEHYQKDKGNLVTRLQVIC-----RSDPPPHDVR 111



 Score = 66.8 bits (162), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 24/142 (16%), Positives = 43/142 (30%), Gaps = 43/142 (30%)

Query: 6   VYHGKISRETGEKLL----------------------------------LATGLDGSYLL 31
            YHG + R      L                                  L     G+YL+
Sbjct: 284 WYHGTLERTAAVDYLKDFAVKLLPNLAHRQQQQQPDRDGNKENGECLDGLEQSTSGTYLV 343

Query: 32  RDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
           R S        L +LY      + + + +      +  P     +   +++LI  + +  
Sbjct: 344 RYSAKQNVD-VLTMLYDNEPKHFIIQRQQD-WLYIDEGP-----YMNSLEHLIEHYTRFS 396

Query: 92  QGIVTPLQYPVEKSSGRGPQAP 113
            G+   L++PV  + G  P  P
Sbjct: 397 DGLPINLRFPV--TPGPKPPIP 416


>UniRef50_O15357 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 n=31
           Tax=Euteleostomi RepID=SHIP2_HUMAN
          Length = 1258

 Score =  128 bits (323), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 50/119 (42%), Positives = 69/119 (57%), Gaps = 2/119 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
            A + YH  +SR   E+LL   G DGS+L+RDSESV G + LCVLYQ +++TYR+     
Sbjct: 17  QAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGE 76

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
              + +T+ GV  R F+ +  LI  + +P+QG+V  L  PVE    R P  P  R  SD
Sbjct: 77  DFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVE--GEREPDPPDDRDASD 133


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score =  128 bits (322), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 9/115 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           +D    + GKI+RE  E+LL    + G +L+R+S + PG Y LCV+       +  YRV 
Sbjct: 27  LDLANWFFGKITREKAEELLTPREV-GLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 85

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            T     + +        FF  +  LI  +++   G+ T L+ P++K +    Q+
Sbjct: 86  STNDNRVTVD-----EDAFFPNLIELIKHYERDADGLCTMLKKPLKKKTEMVLQS 135


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  128 bits (322), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 8/124 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +DA   + GKI R   EK+L  +    GS+L+RDSE+ PG + L V  Q  +  YRV + 
Sbjct: 117 LDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRL 176

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP--TGRR 117
           E GS          +  F+ +  L+  ++    G+   L YP  ++              
Sbjct: 177 EDGSLFV-----TRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAGLLRQANE 231

Query: 118 DSDI 121
           + +I
Sbjct: 232 EWEI 235


>UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa RepID=O77440_HYDAT
          Length = 624

 Score =  127 bits (320), Expect = 9e-29,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 7/120 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +  +HG+I+R+  E  L  T    DG+YLLR+S S  G Y L V     +  Y + +  +
Sbjct: 7   LRWFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSVCKDKKVIHYAIQRQPS 66

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDI 121
           G       P      F     L++  +    G++T L YP E+ +G    A  G    D+
Sbjct: 67  GMVGIADGPQ-----FPGPVELVNHHKTSLGGLMTKLTYPCERPAGVKATAYKGISHDDL 121



 Score = 88.0 bits (217), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 25/101 (24%), Positives = 45/101 (44%), Gaps = 5/101 (4%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             +HG I R   E+ L +    G +L+R+  S  G Y + + YQG +Y Y       G  
Sbjct: 160 PWFHGVIPRTEAERRLKSLSETGMFLIRERGSPRGSYVIGLFYQGGVYHYLFESNNQGQL 219

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           S ++      R F  +  +++ + +  +G+   L+   E S
Sbjct: 220 SIKSG-----RSFDNLMAVVNFYSQKSEGLFCTLKRACEVS 255


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  127 bits (320), Expect = 9e-29,   Method: Composition-based stats.
 Identities = 29/127 (22%), Positives = 54/127 (42%), Gaps = 14/127 (11%)

Query: 1   MDAVTVYHGKISRETG-EKLLLATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           M+    ++  +SR     +LL      GS+L+R+SE+ PG + + V          I  Y
Sbjct: 115 METEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHY 174

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           R+   + G +        +K  F  +  L+  + +   G+ T L  P +    R PQ P 
Sbjct: 175 RIRNMDAGGFYI-----TNKISFNSLSELVKHYSREADGLCTRLVKPCQ---TRAPQKPW 226

Query: 115 GRRDSDI 121
            + + ++
Sbjct: 227 WQDEWEV 233


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 34/105 (32%), Positives = 53/105 (50%), Gaps = 7/105 (6%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHG I+RE  EK+L     DG++L+RDS + PG Y LC+ + G +  YR+ Q   G  +
Sbjct: 46  WYHGNITREHTEKILSGQ-ADGTFLVRDSTNFPGDYTLCMAFNGKVEHYRIYQL-NGILT 103

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
            +     H+  F  +  LI+ +++   G+   L  PV     R  
Sbjct: 104 CD-----HEETFDNLTQLIAHYKRDADGLCHRLITPVISDDYRIT 143


>UniRef50_C1BZH2 SH2 domain-containing protein 1A n=3 Tax=Euteleostei
           RepID=C1BZH2_ESOLU
          Length = 147

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 61/111 (54%), Positives = 71/111 (63%), Gaps = 9/111 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           + + VYHG  S+E GE  L   G DGSYL+R+SES  GVYCLCVL         +     
Sbjct: 4   EKLPVYHGATSKEEGELRLWKDGRDGSYLIRNSESRDGVYCLCVL---------LFMDGE 54

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
           GSW+AETA GV +R+FRK+KNLISAFQKPDQGI T L YPV     R P  
Sbjct: 55  GSWTAETAAGVERRYFRKIKNLISAFQKPDQGIATHLLYPVTVQINRNPDG 105


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +H  ISRE  EKLL     DG++L+R+S + PG + LC+ Y G +  YR+ QT  
Sbjct: 144 NNQPWFHSMISRENTEKLLRGKP-DGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSG 202

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           G  + +      + +F  +  L+S +++   G+   L  P+
Sbjct: 203 GQLTCDK-----EEYFSNLTQLVSHYKRDADGLCHRLVTPI 238


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 4/116 (3%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-- 59
           D +  YHG +SRE  ++LL     DG++L+R+S +  G + L +L QG +  Y+V +   
Sbjct: 6   DPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGG 65

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           E   +S +    V  +    +  L+  +Q+   G+ T L  P+ +          G
Sbjct: 66  EDAFFSIDD--KVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHG 119



 Score = 83.4 bits (205), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 29/144 (20%), Positives = 52/144 (36%), Gaps = 29/144 (20%)

Query: 6   VYHGKISRETGEKLLLATGLD-----------GSYLLRDSESVPGV-YCLCVLYQGYIYT 53
            YHG ++RE    +L     +           G +L+R SES       L +L    +  
Sbjct: 288 WYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKN 347

Query: 54  YRVSQ------------TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           +R+SQ              +     +  P     ++  V++LI+ F +   G+   L+YP
Sbjct: 348 FRISQADLYQNGNKVQSGGSKFLYIDDGP-----YWPSVEHLIAHFMRFSYGLPVSLKYP 402

Query: 102 VEKSSGRGPQAPTGRRDSDICLNA 125
           V         +      S++   A
Sbjct: 403 VPPQPKPEVPSFATIPRSNMKPKA 426


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 6/111 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG +SR+ GE LL  +G+ GS+L+R SES PG   + V + G +Y YR+SQ   G 
Sbjct: 239 YSWYHGAVSRQAGEHLL-RSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGL 297

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           +            F  V  LI    +   G+V PL Y V K          
Sbjct: 298 FYI-----TEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQ 343


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score =  126 bits (316), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 28/116 (24%), Positives = 54/116 (46%), Gaps = 4/116 (3%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-- 59
           +++  +HG +SRE  + LL     DG++L+R+S +  G + L +L Q  +  Y+V +   
Sbjct: 6   ESMKWFHGNLSREAADDLLKQGYEDGTFLVRESSTAAGDFVLSLLCQEEVCHYQVRRHGG 65

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           E   +S +    V  +    +  L+  +Q+   G+ T L  P+ +          G
Sbjct: 66  EDAFFSIDD--KVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDPPPHNTRSHG 119



 Score = 74.1 bits (181), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 26/134 (19%), Positives = 44/134 (32%), Gaps = 29/134 (21%)

Query: 4   VTVYHGKISRETGEKLLLATGLD-----------GSYLLRDSESVPGV-YCLCVLYQGYI 51
              YHG  SRE     L     +           G +L+R SES       L +      
Sbjct: 286 EQWYHGTQSREEAVANLKKFAKELESKNPQIDTSGCFLVRYSESAAATGLVLTLFCDQVA 345

Query: 52  YTYRVSQ------------TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
             +R+SQ              +     +  P     ++  +++LI+ F +   G+   L+
Sbjct: 346 KNFRISQADLYQNGVKLQSGGSKFLYIDDGP-----YWPSLEHLIAHFMRFSYGLPVSLK 400

Query: 100 YPVEKSSGRGPQAP 113
           YPV         + 
Sbjct: 401 YPVPPLPKPEVPSF 414


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  126 bits (316), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 33/122 (27%), Positives = 56/122 (45%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  T YHG +SR   E LL ++G++GS+L+RDSES  G   + V +   +Y YR++   
Sbjct: 82  LNMHTWYHGAVSRAAAEYLL-SSGINGSFLVRDSESCRGHLSVSVRFNASVYHYRINVDT 140

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP-QAPTGRRDS 119
            G +         +  F+ +  L+        G+   L YP  KS+            + 
Sbjct: 141 AGLFYIS-----PEHRFQTLPELVHHHSYASDGLAAILHYPAAKSTKPAVYSMAPDYDEW 195

Query: 120 DI 121
           +I
Sbjct: 196 EI 197


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 4/120 (3%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   + GKI+R   EK L       GS+L+R+SES PG Y L +     +  YRV   
Sbjct: 232 LESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRDGDTVRHYRVENY 291

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
           E G +  +   G   + F  +  LI+   +   G+ T L+ P  K S       T     
Sbjct: 292 EGGLYKLQ---GSPTQKFASLPELIAFHGQRKAGLATALREPCPKESAPMASDLTFDTHD 348


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  125 bits (314), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++     HG ISR   + LL   G+DG YL+R+S+S PG Y L V  +G    YR+++ +
Sbjct: 69  LELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPGQYTLDVWKEGKSVHYRITKGD 128

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
            G +  +         F  +  LI   Q    G+ + L +   K+  +
Sbjct: 129 EGYFFRQG------VCFPTIPELIQHHQTRSDGLCSSLDHIAPKAHAK 170


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  124 bits (313), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 31/111 (27%), Positives = 48/111 (43%), Gaps = 6/111 (5%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           + A   + G I R   EK LL +    GS+L+R+SES  G + L VL    +  YR+ + 
Sbjct: 111 LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRL 170

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           + G +         +R F  +   +S + K   G+   L  P  K     P
Sbjct: 171 DEGGFFL-----TRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAP 216


>UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=35 Tax=Euteleostomi
           RepID=Q64725-2
          Length = 606

 Score =  124 bits (311), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 32/136 (23%), Positives = 64/136 (47%), Gaps = 19/136 (13%)

Query: 2   DAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  +HG ISR+  E+ +L+ +  +G +L+R  ++  G + LC+L++G +  YR+ + +
Sbjct: 163 EKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNN-GSFALCLLHEGKVLHYRIDRDK 221

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK-----------SSGRG 109
           TG  S         + F  +  L+  +     G++  L  P +K           ++   
Sbjct: 222 TGKLSIPEG-----KKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPV 276

Query: 110 PQAPTGRR-DSDICLN 124
           P  P G R +S +  N
Sbjct: 277 PPPPQGSRPESTVSFN 292



 Score =  101 bits (253), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 28/112 (25%), Positives = 49/112 (43%), Gaps = 6/112 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +T + G I+RE  E  L+  G  DG YLLR S +  G + L V +    + Y + +  
Sbjct: 10  NHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIEREL 69

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            G+++         R      +L     +  +G+V  L+ P  +  G  P+ 
Sbjct: 70  NGTYAISGG-----RAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKT 116


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score =  123 bits (310), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 30/110 (27%), Positives = 56/110 (50%), Gaps = 6/110 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           + +  +HGKISRE  E++L   G DG +++R+S S  G + L VL+Q  +  Y++ +  +
Sbjct: 5   ENLCWFHGKISRERAEEILRQEGGDGVFMVRESASSEGDFVLSVLFQDEMVHYQIRRHGD 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
              +S +    +H      +++LI  +++   G+VT LQ           
Sbjct: 65  DAFFSIDDHTPIH-----GLESLIEHYRESPNGLVTKLQAICRGKPPPHD 109



 Score = 58.7 bits (141), Expect = 6e-08,   Method: Composition-based stats.
 Identities = 24/158 (15%), Positives = 47/158 (29%), Gaps = 50/158 (31%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-----------------------------LDGSYLLR 32
           +    YHG + R+    +L                                   G YL+R
Sbjct: 280 NKSQWYHGTLDRQIAVDILKEHAGKLMPGACSPSKEDKENDSTRSNDNETLDTSGVYLVR 339

Query: 33  DSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQ 92
            S    GV  L +L+      + + + +      +  P     +   +++LI  + +   
Sbjct: 340 YSPKQ-GVDVLTLLFDNEARHFIIQR-KQNYLYIDDGP-----YMASLEHLIEHYSRFSD 392

Query: 93  GIVTPLQYP--------------VEKSSGRGPQAPTGR 116
           G+   L+YP              + K+  + P  P   
Sbjct: 393 GLQINLKYPVPPKPKPPIPLFSTIPKTKHKKPTTPEDS 430


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  123 bits (310), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 8/124 (6%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   Y  KI R   EK LLL     G++L+RDSES    Y L V     +  YR+ Q 
Sbjct: 125 IEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQL 184

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT--GRR 117
           + G +         +  FR ++ L+  + K   G+   L  P  +      +  +   R 
Sbjct: 185 DEGGFFI-----ARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRD 239

Query: 118 DSDI 121
             +I
Sbjct: 240 QWEI 243


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 32/121 (26%), Positives = 50/121 (41%), Gaps = 9/121 (7%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   Y GKI R   EK LLL     G++L+RDSES    + L V     +  YR+ Q 
Sbjct: 142 IEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFSLSVRDGDTVKHYRIRQL 201

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
           + G +         +  FR ++ L+  +     G+   L+ P            +G   S
Sbjct: 202 DEGGFFI-----ARRTTFRTLQELVDHYGNEADGLCVNLRKPC---VQVEKPMTSGLSHS 253

Query: 120 D 120
            
Sbjct: 254 T 254


>UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostomi RepID=KSYK_HUMAN
          Length = 635

 Score =  123 bits (308), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 32/116 (27%), Positives = 59/116 (50%), Gaps = 7/116 (6%)

Query: 2   DAVTVYHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  +HGKISRE  E++ L+ +  +G +L+R  ++  G Y LC+L++G +  YR+ + +
Sbjct: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
           TG  S         + F  +  L+  +     G++  L  P +K   +G     GR
Sbjct: 223 TGKLSIPEG-----KKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273



 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 27/112 (24%), Positives = 47/112 (41%), Gaps = 6/112 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  + G I+RE  E  L+  G  DG YLLR S +  G + L V +    + Y + +  
Sbjct: 11  NHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIEREL 70

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            G+++         R      +L     +   G+V  L+ P  +  G  P+ 
Sbjct: 71  NGTYAIAGG-----RTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKT 117


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score =  122 bits (307), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 6/111 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG +SR+ GE LL  +G+ GS+L+R SES PG   + V + G +Y YR+SQ   G 
Sbjct: 76  YSWYHGAVSRQAGEHLL-RSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGL 134

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           +            F  V  LI    +   G+V PL Y V K          
Sbjct: 135 FYI-----TEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQ 180


>UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS
          Length = 938

 Score =  122 bits (307), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 29/118 (24%), Positives = 55/118 (46%), Gaps = 7/118 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           D +  +H  +SRE  + LL     DG++L+R+S +  G + L +L Q  +  Y+V +  E
Sbjct: 5   DHMKWFHANLSREAADDLLRQGYEDGTFLVRESSTAAGDFVLSILCQEEVCHYQVRRHGE 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
              +S +    +  +    ++ L+  +Q+   G+ T L  P+ +     P     RR 
Sbjct: 65  DAFFSIDDE--MQTKILHGLETLVDYYQQGANGLPTKLTVPLIRD----PPPHNTRRH 116



 Score = 62.6 bits (151), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 27/121 (22%), Positives = 46/121 (38%), Gaps = 29/121 (23%)

Query: 4   VTVYHGKISRETG---------EKLLLATGLD--GSYLLRDSESVPGV-YCLCVLYQGYI 51
              YHG  +R+           E L    G+D  G +L+R SES       L +L    +
Sbjct: 284 EQWYHGTQTRDEAVATLTQYAKELLAKQPGVDTSGCFLVRYSESPAASGLVLTLLSDQVV 343

Query: 52  YTYRVSQ------------TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
             +R+SQ             E      +  P     ++  +++LI+ F +   G+   L+
Sbjct: 344 KNFRISQAYLYTNGVKVQSDEQKFVFIDDGP-----YWPSLEHLIANFMRFSYGLPVSLK 398

Query: 100 Y 100
           Y
Sbjct: 399 Y 399


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  122 bits (306), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 6/105 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +A   Y G + R   EK L+  GL  G++L+R +E+  G + L V     +  YRV + +
Sbjct: 122 EAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLSVRDGDSVKHYRVRKLD 181

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           TG +   T        F  +  L+  + K   G+V  L  P  K 
Sbjct: 182 TGGYFITTRAP-----FNSLYELVQHYTKDADGLVCALTLPCPKD 221


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  121 bits (303), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 37/116 (31%), Positives = 56/116 (48%), Gaps = 9/116 (7%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIY-TYRVSQTETGS 63
             YH  ISR T E LL  +G+DGS+L+R+S S PG Y + +   G     YR++    G 
Sbjct: 127 PWYHSNISRNTAEYLL-KSGVDGSFLVRESLSSPGEYSITLRCDGKARTHYRINHDARGY 185

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL-QYPVEKSSGRGPQAPTGRRD 118
           + A        +FF  V+ L++       G+V  L Q+PVEK+  +         +
Sbjct: 186 FVAAG------KFFATVEQLVAHHAVVADGLVACLKQHPVEKAEAKPLVLSKEEDE 235


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score =  120 bits (302), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 29/111 (26%), Positives = 58/111 (52%), Gaps = 6/111 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           + ++ +HGK+SR+  EKL+     +G +L+R+S + PG + L +L+ G I  Y++ +  E
Sbjct: 5   ECISWFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGE 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
              +S +      +  F  ++ LI+  Q+ + G++T L    +K       
Sbjct: 65  DAFFSIDN-----EHIFHGLETLINYHQENENGLITKLTNFCKKDPPPHDT 110



 Score = 90.7 bits (224), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 25/100 (25%), Positives = 47/100 (47%), Gaps = 7/100 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     YHG + R+   +LL   G  +GSYL+R S    GVY L ++     + +++ + 
Sbjct: 279 LSKYNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVNDRSFHFQI-KN 337

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
           E G +  +  P         ++++I  + +   G+ T LQ
Sbjct: 338 ENGYYFIDDGP-----LLESLEHVIDYYSRMQDGLPTVLQ 372


>UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S7K1_TRIAD
          Length = 864

 Score =  119 bits (300), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 10/120 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+ +  Y+  +S E  E LL     DG++L+R S  VPG + L + Y+   + +R+ +  
Sbjct: 1   MENLANYYIDVSYEQAEDLLRLEDQDGAFLIRPSHRVPGTFALSIRYRNKFFHHRI-KVF 59

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G +  E   G  ++ F  +  L+  F++P+QG+  PL   V       P  PT   +S+
Sbjct: 60  HGRFVCE---GFTEKTFSSMDELVKHFRQPNQGLAHPLTKSV------SPPTPTEEDESN 110


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 10/123 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLA---TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           DA   YHGKI+RE    L+     T  +G +L+R+S   PG Y L +  +G +  +++  
Sbjct: 6   DAERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQIMG 65

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
              G +S +  P      F+ +  LI  +Q    G+   L   V  +    P     R +
Sbjct: 66  HGEGWFSVDNGP-----LFQGLDELIHHYQLKPDGLPVQLNDYVIGN--PPPPGARKRTE 118

Query: 119 SDI 121
           +++
Sbjct: 119 TEL 121



 Score =  100 bits (249), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 6/112 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           M+     H  I R    + L   GL DGS+L+R +   PG Y L ++Y+   Y Y V   
Sbjct: 287 MNTNDFLHKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTPYHYEVVCE 346

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
               +  +  P      F  +  ++  +     G+ T L YPV  S  +   
Sbjct: 347 SDCWYFIDDGP-----LFDTLPAVVDHYTIFADGLPTTLLYPVPPSGRKNVP 393


>UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine kinase n=3
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48523
          Length = 837

 Score =  118 bits (295), Expect = 8e-26,   Method: Composition-based stats.
 Identities = 28/125 (22%), Positives = 53/125 (42%), Gaps = 7/125 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     +HG + R+   + +   G  DG +LLR S + P    L +   G ++ + ++ T
Sbjct: 346 LQGKPWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEIN-T 404

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
           +  S+  +  P     +F  ++ LI  + + D G+ T L +P+    GR    P  R   
Sbjct: 405 KMESFYIDDGP-----YFDTLEQLIDHYSRYDDGLPTMLLHPIPPPPGRIDNGPPTREKP 459

Query: 120 DICLN 124
                
Sbjct: 460 SPAPR 464



 Score =  106 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 25/117 (21%), Positives = 52/117 (44%), Gaps = 14/117 (11%)

Query: 4   VTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           +  +HG+I+R+T   +L   G  +G++L+R+S S  G Y + +++ G    +++      
Sbjct: 74  LLWFHGRITRDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSIMHNGLPQHFQIQCMGDF 133

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY--------PVEKSSGRGPQ 111
            +  +  P      F+ +  LI+ ++    G+ T L          P  +  GR   
Sbjct: 134 YYKIDNGP-----LFQGLDQLINYYRMGSNGLPTKLTVFCNGRIPPPCSRRFGRTTP 185


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score =  117 bits (293), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 29/116 (25%), Positives = 56/116 (48%), Gaps = 10/116 (8%)

Query: 5   TVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             +H K+SRE  E+ +++ G  +G +L+R+  +  G + L + Y  ++Y Y++ +  TG 
Sbjct: 210 PWFHHKLSREEAEQRIVSAGLQEGKFLVRE-RTEEGSFALSLCYNNFVYHYKIDKDCTGQ 268

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
            S +  P      F  +  ++  +Q    G++  L  P   ++      PT RR S
Sbjct: 269 LSIKEGP-----KFDSLIQMVDHYQLKKDGLLCCLLVPCHDNNR---DTPTRRRHS 316



 Score =  109 bits (273), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 6/113 (5%)

Query: 7   YHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           YHG+I+RE  E  L   G   G +LLR+S    G Y L + Y+  +Y Y + +   G+ +
Sbjct: 57  YHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYEDDVYHYAIERQYDGTVA 116

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            +       + F     L+S     + G++  L  P     G   +A +    
Sbjct: 117 IKDG-----KNFAGPIELVSNHMNREDGLLCRLLRPCNLQQGIAARAFSDMDH 164


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score =  117 bits (293), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 11/107 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY-----IYTYR 55
           ++    YH  I+R   E LL     +G++++RDS  + G Y + V          I  Y+
Sbjct: 145 LEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARSTEAAIKHYQ 203

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           + + ++G W         +  F+ +  LI   Q    G++T L+YPV
Sbjct: 204 IKKNDSGQWYV-----AERHAFQSIPELIWYHQHNAAGLMTRLRYPV 245


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  116 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 10/109 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGV----YCLCVLYQGYIYTYR 55
           ++A   Y G I R   EKLL+  G  DGS+L+R SE+  G     + L V  +  I  YR
Sbjct: 124 LEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVRDKELIRHYR 183

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +  T++G +    +     + F  +  LI  ++    G+   L  P  K
Sbjct: 184 IKITDSGKYFISLS-----KEFSTLNELIEFYKISSDGLKIKLLEPCRK 227


>UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepID=HTK16_HYDAT
          Length = 757

 Score =  116 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 29/98 (29%), Positives = 50/98 (51%), Gaps = 6/98 (6%)

Query: 2  DAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
          DA+  YHGKI+RE   + LL   G DG +L+RD  + P  Y L ++++  I  ++++   
Sbjct: 6  DALLWYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRSQILHFQINCLG 65

Query: 61 TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPL 98
             +S +  P      F+ +  LIS ++    G+   L
Sbjct: 66 DNKFSIDNGP-----IFQGLDMLISYYKVISDGLPCKL 98



 Score =  101 bits (252), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 49/122 (40%), Gaps = 6/122 (4%)

Query: 6   VYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             H  + R     +L      DGS+L+R S    G Y L ++Y+   Y +++       +
Sbjct: 287 WLHQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKTYHFQIKSRADRWF 346

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLN 124
             +  P      F  + +L+  + +   G+ T LQ+PV  +  R    P     + + L 
Sbjct: 347 YIDDGP-----LFETLPHLVDHYMQYADGLPTLLQFPVPSAENRKRPLPPTPTKNQLKLP 401

Query: 125 AP 126
            P
Sbjct: 402 VP 403


>UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_SCHMA
          Length = 1264

 Score =  115 bits (289), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 55/124 (44%), Gaps = 8/124 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++   ++GKI+RE  E+LL   G + G +LLR+S +    Y + + + G ++ Y V +  
Sbjct: 45  ESTNYFYGKITREQAEELLFTNGANEGLFLLRESVNR--NYAVSICHLGRVHHYNVERHT 102

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
             S+  +T        F     L+        G +T  Q P+ +  G  P    G   +D
Sbjct: 103 DCSYRIQTG-----HKFIGPVELVQHHSTQLDGFLTLAQLPLNRPVGMSPIVLQGLNAND 157

Query: 121 ICLN 124
           +  N
Sbjct: 158 LEHN 161



 Score = 92.2 bits (228), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 8/103 (7%)

Query: 5   TVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             YH  I R   E  L + G  DG++L+R        Y L +  Q     YR+ +  +  
Sbjct: 201 PWYHHTIRRYEAESRLASEGNQDGAFLVRY-RKEDRTYVLSLTSQNEPKHYRIEEYLS-R 258

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           WS E       ++F  +  LI  +     G++  LQ P+  S+
Sbjct: 259 WSIEGG-----QYFETIMELIDHYHFRQDGLLCKLQKPIPVSN 296


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  115 bits (288), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 30/123 (24%), Positives = 50/123 (40%), Gaps = 7/123 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   Y GK+SR   +  L    LDG++L+R+SE+  G Y L V + G    YR+     
Sbjct: 254 ESEPWYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYRIQHDGN 313

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDI 121
             +         +   + +K LI   +    G+ T L+ P        P    G    +I
Sbjct: 314 EYYI------TTRHRQKTIKELIDYHKLNGGGLCTRLKKPACDDEAPTPHDL-GSDKWEI 366

Query: 122 CLN 124
             +
Sbjct: 367 DPS 369


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  114 bits (287), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 28/122 (22%), Positives = 51/122 (41%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    + G+ISR     +L  T  +G +L+R+SE+ PG Y L + +   +  YR+ Q  
Sbjct: 340 LEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEGVRHYRI-QHI 398

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G +            F  +  LI   +    GIVT L+  +  ++        G    +
Sbjct: 399 EGQYFVN-----ENHRFDSIPQLIEYHKLNGGGIVTRLRRAINDANAPISVGL-GHDMWE 452

Query: 121 IC 122
           + 
Sbjct: 453 LS 454


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  114 bits (285), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 29/128 (22%), Positives = 52/128 (40%), Gaps = 14/128 (10%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           M+    ++  I+R+  E+ LL      GSYL+R+SE+  G Y L +       Q  +  Y
Sbjct: 122 METEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHY 181

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           ++   + G +         K  F  + ++I  + K   G+   L    EK   +    P 
Sbjct: 182 KIRSLDNGGYYIS-----PKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQK---PW 233

Query: 115 GRRDSDIC 122
            +   +I 
Sbjct: 234 DKDAWEIS 241


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score =  113 bits (284), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 38/140 (27%), Positives = 59/140 (42%), Gaps = 21/140 (15%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  YHG ++R   E LLL+ G DGSYLLRDS    G+Y L V  +  +  + V  T 
Sbjct: 30  LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTG 89

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEK---------SS 106
              +S +         F  +K+ +  F        + G +  L++P  +         S 
Sbjct: 90  ---YSFKFGFNE----FSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESV 142

Query: 107 GRGPQAPTGRRDSDICLNAP 126
                  TGR + D+   AP
Sbjct: 143 RVHTAMQTGRTEDDLVPTAP 162


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  113 bits (282), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 9/118 (7%)

Query: 4   VTVYHGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           +  YHGKISR+T E +LL   +  DG +L+R+S S  G Y LCVL    +  Y++ +  E
Sbjct: 10  INWYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQNNEVVHYQIRRHGE 69

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQ-GIVTPLQYPVEKSSGRGPQAPTGRR 117
              +S +    +H      ++ LI  + K +   +   L  P+ K          GR 
Sbjct: 70  DAFFSIDEQNIMH-----GLETLIEHYCKVNDPSLGVQLSKPIVKDPPPHDTRRHGRT 122



 Score = 93.0 bits (230), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 10/110 (9%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHGK+ R     +L    +DG +L+R      G Y L ++     Y +++ Q     + 
Sbjct: 290 WYHGKLDRHEATAILKTKDVDGCFLVRM-NRQSG-YVLSMMCTNQCYHFQI-QDRDKYYF 346

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
            +  P     +   +++LI  +     G+   L+ PV  S    P  P G
Sbjct: 347 IDNGP-----YLNSLEHLIQHYTLFPDGLPNKLEVPV--SPAVIPPLPKG 389


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  112 bits (280), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 27/117 (23%), Positives = 51/117 (43%), Gaps = 11/117 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVL-----YQGYIYTY 54
           + A   Y GK+ R+  E+ LL+ G   G++L+R+SE+  G Y L +         ++  Y
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
           ++ + + G +   T        F  ++ L+  + +   G+   L  P  K   R   
Sbjct: 204 KIRKLDNGGYYITTRAQ-----FETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTD 255


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  111 bits (278), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 27/121 (22%), Positives = 50/121 (41%), Gaps = 7/121 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   +HG+ISR     LL     +G +L+R+SES  G Y L V +   +  Y + +  
Sbjct: 297 IESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGEYSLSVSHGDSLRHYHIKKEG 356

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT-GRRDS 119
              +  +      +  F  +  LI   +    G+VT L+  +             G+ + 
Sbjct: 357 EEFYIND------RHRFPDICKLIEYHKLNSGGLVTRLRKSIADLHTPAAAGLGHGKWEL 410

Query: 120 D 120
           D
Sbjct: 411 D 411


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  111 bits (278), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 53/122 (43%), Gaps = 5/122 (4%)

Query: 1   MDAVTVYHGKISRETGEKLL-LATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   + G I+R   EKLL +     G +L+R+SES PG + L +     +  +RV + 
Sbjct: 336 LEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGENVRHFRVKKV 395

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
             G    + +P    +    + +LI   ++   G+ T L+ P  +           +   
Sbjct: 396 A-GGIKLQGSPSSPHK---DLPSLIKYHKRHRGGLTTTLKVPCPREIRAPDIGYAVKDKW 451

Query: 120 DI 121
           ++
Sbjct: 452 EV 453


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  111 bits (277), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 46/109 (42%), Gaps = 11/109 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           + A   Y GK+ R+  E+LLL  G   G +L+R+SE+  G Y L +          +  Y
Sbjct: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHY 212

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
           ++ + + G +   T        F  ++ L+  + +   G+   L     
Sbjct: 213 KIRKLDNGGYYITTRAQ-----FDTLQKLVKHYTEHADGLCHKLTTVCP 256


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score =  111 bits (277), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 8/123 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           D     HGKISRE  + L+ + G  +G +L+R+S   PG Y L V+ QG +  +++S+ +
Sbjct: 26  DKPPYMHGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALSVVAQGKLQHFKISR-K 84

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           TG +  +  PG     F  +  L+  ++ PD  + T L      +     +    +   +
Sbjct: 85  TGLYRIDDGPG-----FGSLDELVQFYRNPDDRLPTVLVRFCASTVSAS-ELQQYQNHWN 138

Query: 121 ICL 123
             L
Sbjct: 139 ASL 141


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  110 bits (276), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 26/126 (20%), Positives = 51/126 (40%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLY----QGYIYTYR 55
           ++    +     R+  E+ LL      GS+L+R+SE+  G + L V         I  Y+
Sbjct: 119 LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYK 178

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           +   + G +         +  F  ++ L+  + K   G+   L  P  + +   PQ P  
Sbjct: 179 IRCLDEGGYYIS-----PRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPA---PQNPWA 230

Query: 116 RRDSDI 121
           + + +I
Sbjct: 231 QDEWEI 236


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score =  110 bits (275), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 15/130 (11%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL---------YQGYIYTYRV 56
            Y   ++R   ++LL+  G +G++++RDS  + GVY + V              +  Y++
Sbjct: 213 WYSKNMNRMQAQELLMREGKEGAFMVRDSSHM-GVYTVSVFTKAPSQSGEKNPKVKHYQI 271

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK--SSGRGPQAPT 114
            QTETG+     A       F  +  LI   Q    G++T L++PV    SS +   AP 
Sbjct: 272 RQTETGAGPFYLAENY---LFNTIPELIHYHQHNAAGLITRLRHPVSPDGSSAQQVSAPF 328

Query: 115 GRRDSDICLN 124
                ++  +
Sbjct: 329 EADQWELNPD 338


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  108 bits (270), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 53/108 (49%), Gaps = 6/108 (5%)

Query: 5   TVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             Y+G I+R   EKLLL +   DGS+L+R SES    Y +    +G ++ +R+ ++  G+
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGA 308

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
           +         +  F  +  LIS +Q+ ++ +   L+ P  +     P 
Sbjct: 309 YFVSD-----RISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPS 351



 Score = 91.9 bits (227), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 6/111 (5%)

Query: 2   DAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                + G ++R   +  LL     +G++L+R SE     Y L V     +  Y+V QT+
Sbjct: 65  QTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTD 124

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
              +  E       R F  +  L+  +QK       PL  P ++++   P 
Sbjct: 125 QNRFYVEPG-----RRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPA 170



 Score = 74.1 bits (181), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 22/90 (24%), Positives = 37/90 (41%), Gaps = 5/90 (5%)

Query: 22  ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVK 81
               +G++L+R SE     Y L V     +  Y+V QT+   +  E       R F  + 
Sbjct: 731 PENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYVEPG-----RRFSSLA 785

Query: 82  NLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
            L+  +QK       PL  P ++++   P 
Sbjct: 786 ELVDYYQKTSLNNAGPLGNPCKRNTLSTPA 815


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  108 bits (269), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 29/110 (26%), Positives = 49/110 (44%), Gaps = 11/110 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY----QGYIYTYRV 56
           +     +HG I R   E LL  +   G++L+R+SE++ G Y L ++        I  +R+
Sbjct: 63  LTNEPWFHGNIGRIEAENLLQYSEP-GTFLIRESETIKGSYTLTMIQIKDGTKQISHFRI 121

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           +    G +   +A     R F  +  LI  + +   G+   L YP  K S
Sbjct: 122 NYD-DGKYFITSA-----RRFLGLHQLIQHYMQNSDGLACNLVYPQPKPS 165


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score =  107 bits (267), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 12/119 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  YHG +SR   E LL+A   DGSYLLR S +  G Y L V  +  +  +++    
Sbjct: 9   VEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSVKHFQIGWDG 68

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGRGPQAPT 114
                 +   GV    F+ ++  +  F        + GI+T L++P  ++        T
Sbjct: 69  KQY---QFGMGV----FQSLQEFVEHFANQPLIGGESGILTALRHPYSRNVLEPDVYDT 120


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  106 bits (266), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 48/111 (43%), Gaps = 11/111 (9%)

Query: 6   VYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTYRVSQT 59
             +  I+RE  E+LL+  +   GS+L+R+SE+  G Y L +       +  I  YR+ Q 
Sbjct: 89  WLYKGINREKAEELLMVNSNRSGSFLIRESETRSGSYTLSIRKTNHTSRDSIKHYRIHQL 148

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           + G +         +  F  +++++  + +   GI   L  P        P
Sbjct: 149 DNGWFYI-----APRLTFATLQDMVDYYSEVADGICCTLTEPCVVQRVPNP 194


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  106 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 30/111 (27%), Positives = 49/111 (44%), Gaps = 7/111 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HGKIS +   + L     DG +L+R+S   PG Y LCV +   +  YRV    
Sbjct: 117 LSLMPWFHGKISGQEAVQQLQPP-EDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL-HR 174

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
            G  + + A      FF  + +++  + K    I T L  P  K   +  +
Sbjct: 175 DGHLTIDEA-----VFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAE 220


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 48/114 (42%), Gaps = 9/114 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     + GKI R   E++L     DG++L+R+SES PG + L V +   +  ++V +  
Sbjct: 55  MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDG 114

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
            G +            F  +  L+   +      V+  Q    +   + PQ PT
Sbjct: 115 AGKYFL------WVVKFNSLNELVDYHRSTS---VSRNQQIFLRDIEQVPQQPT 159


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 26/112 (23%), Positives = 50/112 (44%), Gaps = 7/112 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D+   +  ++SR   E +L   G +G +++R+S     +Y L + ++G +  Y +   E
Sbjct: 313 LDSEEWFFPQLSRTRAENILKGEGREGGFVVRNSSREN-MYTLSICHEGQVRHYHIKLDE 371

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
           +  +         K  F  +K LI   +    G+VT L+ P        PQ+
Sbjct: 372 SNKYFIS-----EKHRFPSIKELIEYHKLNGGGLVTRLRKP-PVQLAPNPQS 417


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 22/101 (21%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 5   TVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             +H  ++R+    L    G +DG +L+R+S+ +PG + L   +   +  Y+++  E G 
Sbjct: 659 PWFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSFSHNQKVKHYQINMVEDGV 718

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           ++ +         F  +  L+  +Q    G+ T L +   K
Sbjct: 719 YTIDDGG----TRFTDLIQLVEFYQLNSGGLPTRLLHICTK 755


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score =  105 bits (262), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 12/118 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL------YQGYIYTY 54
           +D    + G ISR   E+LL   G +G++++R+S S  G+Y + +        +G +  Y
Sbjct: 291 LDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHY 349

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            V                    F  +  LI   Q    G++T L++PV   + + P +
Sbjct: 350 HVHTNAENKLYL-----AENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDS 402


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score =  104 bits (261), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 11/121 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT- 59
           + +  YHGK+SRE  E LL   G  DGS+L+R+S S  G + L VL+   +  +++ +  
Sbjct: 5   EDIFWYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHS 64

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT---PLQYPVEKSSGRGPQAPTGR 116
           E   +S +    +H      +++LI  +    +GI++    L  PV+  +        GR
Sbjct: 65  EDAFFSIDENTKIH-----GLESLIEHY-VNTKGILSEGLSLTVPVKGDAPPDYSRRHGR 118

Query: 117 R 117
            
Sbjct: 119 T 119



 Score = 69.5 bits (169), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 19/95 (20%), Positives = 40/95 (42%), Gaps = 8/95 (8%)

Query: 6   VYHGKISRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            YHG + R   E  +   +  DG++L+R S+       L ++ +   Y Y + + +    
Sbjct: 286 WYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRN-KERVLTLINESLFYNYIIRKQDD-YL 343

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
             +  P     +   ++++I  +     G+ T LQ
Sbjct: 344 FIDNGP-----YLESLEHIIEYYSFIPDGLPTVLQ 373


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 6/88 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     + GKI R   E++L     DG++L+R+SES PG + L V +   +  ++V +  
Sbjct: 55  MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDG 114

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ 88
            G +            F  +  L+   +
Sbjct: 115 AGKYFL------WVVKFNSLNELVDYHR 136


>UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound protein 14 isoform 1 n=1
           Tax=Pan troglodytes RepID=UPI0000E1F79D
          Length = 491

 Score =  104 bits (260), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 2/103 (1%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +   +H KISR+  ++L++  G +DG +L+RDS+S P  + L + +   I  +++   E 
Sbjct: 387 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED 446

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
                 T    H R F  +  L+  +Q     +   L++   +
Sbjct: 447 DGEMFHTLDDGHTR-FTDLIQLVEFYQLNKGVLPCKLKHYCAR 488


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 10/100 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HG +S +  E+L+L  G +GS+L+R+S+S PG + L V  +  +    +   E     
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRTEDKVTHVMIRWHENKY-- 115

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYP 101
            +   G   + F  +  LI  +++       G V  L+ P
Sbjct: 116 -DVGGG---QKFGTLCELIEHYKRNPMVEICGTVVHLRQP 151


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           ++    +   I+R   E+LL   G +GS+L+R+S S  G   + V        +  Y V 
Sbjct: 256 LEQNRWFCKDITRAKAEQLLRQAGSEGSFLVRES-SQVGKLTVSVYSCIPCEVVKHYHVK 314

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT--- 114
           Q  TG W         K  F  + +LI   Q    G+VT L++PV +     P       
Sbjct: 315 QLPTGEWYL-----AEKHTFSTISDLIHYHQHNAAGLVTRLRHPV-RPGEELPSTAGLSY 368

Query: 115 GRRDSD 120
           G+ + D
Sbjct: 369 GKWELD 374


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/103 (24%), Positives = 45/103 (43%), Gaps = 10/103 (9%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               +HG +S +  EKL+L  G +GS+L+R+S+S PG + L V     +    + + +  
Sbjct: 108 TERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMI-RWQDK 166

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYP 101
            +            F  +  LI  +++       G V  L+ P
Sbjct: 167 KYDVGGGES-----FGTLSELIDHYKRNPMVETCGTVVHLRQP 204



 Score = 91.5 bits (226), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 26/107 (24%), Positives = 39/107 (36%), Gaps = 11/107 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPV 102
              +            F  +  L+  +      K   G    L+ P+
Sbjct: 61  D-FFDLYGGE-----KFATLPELVQYYMENGELKEKNGQAIELKQPL 101


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  103 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 28/117 (23%), Positives = 51/117 (43%), Gaps = 12/117 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   Y G++ R   E  L   G D GS+L+R SES    Y L V  +  +  YR+   
Sbjct: 217 LESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVREENTVKHYRIR-- 274

Query: 60  ETGSWSAETAPGVHKRF------FRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
              S  + T P + + +      F  ++ L++ + +   G+   L  P  + +   P
Sbjct: 275 ---SRYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCIRPTHPEP 328


>UniRef50_A9V255 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V255_MONBE
          Length = 192

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 34/111 (30%), Positives = 53/111 (47%), Gaps = 8/111 (7%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHG+I+RE     LL  G+DGS+LLR S +  GVY L ++    +   R+  T  G ++
Sbjct: 4   YYHGRITREEAVDRLLKEGVDGSFLLRMSTTQDGVYTLSLMQGESVRHIRIVNTIDGGYA 63

Query: 66  AETA-PGVHKRF----FRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
                PGV   +     +    L SA+ + DQ     L+YP++ +      
Sbjct: 64  ISAGDPGVDSVWQLVETQMHNTLTSAYDRSDQ---VALRYPLKANGDVIAP 111


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  101 bits (251), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 31/109 (28%), Positives = 46/109 (42%), Gaps = 12/109 (11%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHG +SR   E LL     DG YL+R+SES PG + L +     I  +++         
Sbjct: 280 WYHGTLSRSECEFLLNEHAKDGEYLIRNSESKPGDFSLSMKAPNRIKHFKILYGNNQYVI 339

Query: 66  AETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSSGRG 109
            +       R F  +  L+S ++       + G    L YP+ KS  R 
Sbjct: 340 GQ-------RSFSNIDELLSHYKNYPIYTTENGQKMHLLYPLNKSFTRN 381


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 26/65 (40%), Positives = 43/65 (66%), Gaps = 1/65 (1%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 249 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 307

Query: 61  TGSWS 65
            G  +
Sbjct: 308 DGKVA 312


>UniRef50_UPI000180D2FE PREDICTED: similar to SYK n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2FE
          Length = 635

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 5/100 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
              YHG ISR    +L+    +DGS+LLR S   P  Y + V YQG +  Y +  +    
Sbjct: 8   EVYYHGPISRSEATELVKGQ-VDGSFLLRKSLREPDGYAISVSYQGSVLHYSIQHSTVSG 66

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
           W +      H       + L   + +   G+ T L +P++
Sbjct: 67  WYSVNKGSEH----PSPQALCKYYMQEKGGLKTKLLWPIK 102



 Score = 70.7 bits (172), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 25/120 (20%), Positives = 49/120 (40%), Gaps = 14/120 (11%)

Query: 2   DAVTVYHGKISRETGEKLLLAT----GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS 57
           +    YHG+I+R+     L  +      +G YL+R  E+  GV+ L V+    ++ Y++ 
Sbjct: 140 EEQEWYHGEITRQEDAVRLSHSYRELNKNGIYLIRFKEN--GVFVLSVVNDKKVHRYKIL 197

Query: 58  QTETG-SWSAETAPGVHKRFFRKVKNLISAFQKPD---QGIVTPLQYPVEKSSGRGPQAP 113
           Q  +   +S    P      F  ++ LI   ++       +   L  P ++S+       
Sbjct: 198 QNTSNLKYSINGKPPE----FLSLEQLIQFHEEQPPEISHLHCRLTLPCKRSTSASVIPQ 253


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score =   99 bits (248), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 23/109 (21%), Positives = 49/109 (44%), Gaps = 7/109 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  YH  ++R+  ++++  T  DG++L+R+  S P +Y L   +QG +  Y +    
Sbjct: 542 VEKLLWYHADMTRQEADQVMQNTN-DGTFLVRN-ASKPKMYTLSFSFQGVVKHYHIKTDS 599

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
              +         +  F  V  LI   +    G+ T L++P   ++   
Sbjct: 600 DNLFYVS-----QRHSFESVVQLIEYHKLNSAGLATRLRFPYTGTNNPP 643


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =   99 bits (248), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 15/129 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY------QGYIYTY 54
           ++    Y   ++R   E+LL   G +G +++RDS S  G Y + V        QG I  Y
Sbjct: 276 IEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHY 334

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
            V  T    +         K  F  +  LI+  Q    G+++ L+YPV + +   P    
Sbjct: 335 VVCSTPQSQYYL-----AEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAG 389

Query: 115 ---GRRDSD 120
              G  + D
Sbjct: 390 LGYGSWEID 398


>UniRef50_C4Q4M0 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4Q4M0_SCHMA
          Length = 921

 Score = 99.6 bits (247), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 5/98 (5%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HG ISRE  E+LL     +G++L+R S S    Y L V+Y   +Y Y + +   G + 
Sbjct: 63  WFHGNISREDTERLLKHHLQNGTFLIRFSISTHK-YVLSVIYNQQLYHYPIEELSDGFYQ 121

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
                G + ++   +  L+S F++ +  IV  L  PV 
Sbjct: 122 VN---GTNAKYL-GIDLLVSEFRRANNCIVCSLGKPVP 155



 Score = 68.0 bits (165), Expect = 8e-11,   Method: Composition-based stats.
 Identities = 20/111 (18%), Positives = 41/111 (36%), Gaps = 14/111 (12%)

Query: 6   VYHGKISRETGEKLLLATG--LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS------ 57
            YH  +S+   +K+        DG++L+R S      + L + YQ     Y++       
Sbjct: 346 WYHPSLSKSETDKIFSNCSTIKDGAFLIRRSSQSERKFVLVLYYQHQTLKYQIEVVDFSF 405

Query: 58  -QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
                 ++  +  P         +++L+  + +   GI   L Y +  S  
Sbjct: 406 HMDTKEAYFIDKGPLHL-----SLEHLVEHYSRFADGIPVRLHYAISPSGR 451


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score = 99.2 bits (246), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 21/86 (24%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
              Y G+ISR+  E++L+     G++L+R+SES PG + + V Y   +  ++V +  +G 
Sbjct: 58  HPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK 117

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQK 89
           +         +  F  +  L+  ++ 
Sbjct: 118 YFL------WEEKFNSLNELVDFYRT 137


>UniRef50_A9V2L8 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2L8_MONBE
          Length = 877

 Score = 99.2 bits (246), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 6/107 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           A    HG+ISRE  E LL   G  DG +L+R S SVPG + L + ++  I  + +    T
Sbjct: 299 ANDWLHGEISREVAEALLKQQGAADGLFLVRRSTSVPGAFVLSLCHRDDILHHIIYAGHT 358

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
                +    +       + + +S FQ P  G +TPL   V +++  
Sbjct: 359 CYQIFD----IEADTLEGLIHFLSDFQ-PQHGWLTPLNMHVPRAASE 400


>UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_HUMAN
          Length = 276

 Score = 98.8 bits (245), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 51/111 (45%), Gaps = 11/111 (9%)

Query: 6   VYHG----KISRETGEKLL-LATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           VYHG     + R+  E+LL L     GS+++R+SE+  G Y L V ++  +  YR+ +  
Sbjct: 80  VYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFRLP 138

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
              +         +  F+ +++L++ + +   G+   L  P    S   P 
Sbjct: 139 NNWYYIS-----PRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAPA 184


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score = 98.8 bits (245), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 20/99 (20%), Positives = 40/99 (40%), Gaps = 11/99 (11%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGY-----IYTY 54
           ++    +   +SR+  E+ LL      GS+L+R+SES  G + L V          +  Y
Sbjct: 180 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 239

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQG 93
           ++   + G +         +  F  +  L+  + +   G
Sbjct: 240 KIRNLDNGGFYIS-----PRITFPGLHELVRHYTRYYNG 273


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score = 98.4 bits (244), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 27/99 (27%), Positives = 47/99 (47%), Gaps = 4/99 (4%)

Query: 6   VYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-TETGS 63
            +HG+I RE   K+++  G  DG +LLRDS+S P  + L + +   I  +++    E G 
Sbjct: 507 WFHGRIVREEAHKMIIQQGQVDGLFLLRDSQSNPRAFVLTLCHHQKIKHFQILPCEEDGQ 566

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
                  G  K  F  + +L+  +Q     +   L++P 
Sbjct: 567 VFFSLDDGSTK--FTDLIHLVDFYQLNRGVLPCKLKHPC 603


>UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=Euteleostomi
           RepID=Q5SUW3_MOUSE
          Length = 550

 Score = 98.0 bits (243), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 24/100 (24%), Positives = 48/100 (48%), Gaps = 2/100 (2%)

Query: 6   VYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            +HG+ISRE   +++   G +DG +LLRDS+S P  + L + +   I  +++   E    
Sbjct: 449 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 508

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +  T    + + F  +  L+  +Q     +   L++   +
Sbjct: 509 TFFTLDDGNTK-FSDLIQLVDFYQLNKGVLPCKLKHHCIR 547


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score = 96.9 bits (240), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 29/110 (26%), Positives = 44/110 (40%), Gaps = 7/110 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MD +  +HG + R   E  +   G +G +L+R S S  G Y L V YQG    +++    
Sbjct: 1   MDQL-FFHGSVPRAEAEAKVQRGG-NGVFLIRQSSSDSGSYVLSVGYQGEALHFKIKNEG 58

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
              +S +  P      F  + +L   F     G+   L  PV   S    
Sbjct: 59  ECWFSIDEGP-----VFEGLADLTEHFVHFPDGLPCNLTSPVLVRSAEID 103



 Score = 95.7 bits (237), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 24/116 (20%), Positives = 52/116 (44%), Gaps = 8/116 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE-T 61
           +  YHGK++R   E ++   G  DG +L+R S+   G + L + +    + +++  ++  
Sbjct: 246 LEYYHGKLNRVAAENIITIYGSNDGLFLVRFSKGS-GNFILSMCFNQSCFHFQIQCSQAE 304

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
             +  +  PG     F  + +LI  ++    G+   L    ++S+  G  +P    
Sbjct: 305 NCYFIDDGPG-----FTSLGDLIQHYRLKSDGLPCVLTRFCKRSARSGGLSPDEED 355


>UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q3ZB94_DANRE
          Length = 271

 Score = 96.9 bits (240), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 28/116 (24%), Positives = 52/116 (44%), Gaps = 11/116 (9%)

Query: 5   TVYHG----KISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
            VYHG     +SR+  E+LL   G   GS+L+R+S    G+Y L V ++  +  Y++ + 
Sbjct: 79  KVYHGWLFEGVSRQKAEELLSLPGNSAGSFLIRESPRERGLYSLSVRHR-SVKHYKIFRL 137

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
               +         +  F+ ++++++ +     GI   L  P    S   P +  G
Sbjct: 138 TNSWYYIS-----PRLTFQCLEDMVNHYSDSSDGICCVLSAPCLALSNPTPSSIQG 188


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score = 96.5 bits (239), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 28/108 (25%), Positives = 45/108 (41%), Gaps = 6/108 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           +  + G I+RE  E  L   G  DG YLLR S S  G Y L + Y    Y Y + +    
Sbjct: 8   LPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELND 67

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           +++            R   ++I+   +   G++  L+ P  +  G  P
Sbjct: 68  TYAIAGGKSH-----RTPIDVINYHSQESDGLICLLKKPFHRPRGTEP 110



 Score = 84.9 bits (209), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 22/115 (19%), Positives = 45/115 (39%), Gaps = 15/115 (13%)

Query: 2   DAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVY------CLCVLYQGYIYTY 54
           + +  +HGKI RE  E +LL  + ++G      +++    +       LC+L+   +  Y
Sbjct: 159 EKMPWFHGKIDREDSELRLLNTSRVNGQI---SNQTKRKQWQKRVPNALCLLHNNQVMHY 215

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
           R+ +   G  S         + F  +  L+  +     G++  L     + S   
Sbjct: 216 RIDKDRAGKLSIPDG-----KKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHS 265


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score = 96.5 bits (239), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 26/132 (19%), Positives = 48/132 (36%), Gaps = 15/132 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQ--------GYI 51
           ++A   +   +SR+  E+LLL  G   G +L+R+SE+  G   L V  +          +
Sbjct: 174 VEAEEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTV 233

Query: 52  YTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV-EKSSGRGP 110
             YR+   +   +   T     K  F  ++ LI  +     G+   L             
Sbjct: 234 KHYRIKHPDYRYYYITT-----KCSFSSLQELIQFYSIDSHGLCCKLTRACLCPPPITSD 288

Query: 111 QAPTGRRDSDIC 122
            +   +   +I 
Sbjct: 289 LSVKTKDHWEIS 300


>UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax=Euteleostomi
           RepID=GRB10_HUMAN
          Length = 594

 Score = 96.1 bits (238), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 24/103 (23%), Positives = 47/103 (45%), Gaps = 8/103 (7%)

Query: 6   VYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG-- 62
            +HG+ISRE   +++   G +DG +LLRDS+S P  + L + +   I  +++   E    
Sbjct: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552

Query: 63  -SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
             +S +         F  +  L+  +Q     +   L++   +
Sbjct: 553 TFFSLDDGN----TKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 591


>UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleostomi
           RepID=ZAP70_HUMAN
          Length = 619

 Score = 95.7 bits (237), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 44/111 (39%), Gaps = 6/111 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
            +  ++G ISR   E+ L   G  DG +LLR      G Y L +++    + + + +   
Sbjct: 7   HLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLN 66

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
           G+++                 L   + +   G+   L+ P  + SG  PQ 
Sbjct: 67  GTYAIAGGKAHC-----GPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQP 112



 Score = 91.5 bits (226), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 7/103 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  YH  ++RE  E+ L +    DG +LLR  +   G Y L ++Y   +Y Y +SQ +
Sbjct: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
            G +            F  +  L+   +    G++  L+    
Sbjct: 218 AGKYCIPEGT-----KFDTLWQLVEYLKLKADGLIYCLKEACP 255


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score = 95.7 bits (237), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 12/108 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  I+    E LLL  G+DGS+L R S+S PG + L V   G +   ++  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPV 102
              +            F  +  L+  +       K   G V  L+YP+
Sbjct: 61  D-YYDLYGGE-----KFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102



 Score = 93.0 bits (230), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 25/114 (21%), Positives = 44/114 (38%), Gaps = 19/114 (16%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG----------YIY 52
           +   +HG +S    EKLL   G +GS+L+R+S+S PG + L V               + 
Sbjct: 109 SERWFHGHLSGREAEKLLTEKGKNGSFLVRESQSHPGDFVLSVRTGDDKTDSSDSKPKVT 168

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYPV 102
              +       +            F  + +L+  ++K       G V  L+ P+
Sbjct: 169 HVMIRCQHDLKYDVGGGE-----KFDSLTDLVEHYKKNPMVETLGTVLQLKQPL 217


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score = 95.7 bits (237), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 12/108 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  I+    E LLL  G+DGS+L R S+S PG + L V   G +   ++  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPV 102
              +            F  +  L+  +       K   G V  L+YP+
Sbjct: 61  D-YYDLYGGE-----KFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102



 Score = 88.0 bits (217), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 27/114 (23%), Positives = 46/114 (40%), Gaps = 20/114 (17%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG----------YIY 52
           +   +HG +S +  EKLL   G  GS+L+R+S+S PG + L V               + 
Sbjct: 109 SERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVT 168

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYPV 102
              +   E      +   G     F  + +L+  ++K       G V  L+ P+
Sbjct: 169 HVMIRCQE---LKYDVGGG---ERFDSLTDLVEHYKKNPMVETLGTVLQLKQPL 216


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score = 95.3 bits (236), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 24/106 (22%), Positives = 55/106 (51%), Gaps = 13/106 (12%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HG+I+R+  EK+L   G  G +L+R+SE++PG + + V     +  ++V+++      
Sbjct: 291 WFHGRITRQDSEKILGCPGESGLFLIRESETMPGDFAVSVKAPERVKHFKVTRS------ 344

Query: 66  AETAPGVHKRFFRKVKNLISAFQK-----PDQG-IVTPLQYPVEKS 105
            +    + +R F  + +L+  +++      D G +   L  P +++
Sbjct: 345 -DKKFCIGQRKFESLDDLVDHYKRSPIFSSDDGELKLYLTRPNQRN 389


>UniRef50_UPI0000E1FA37 PREDICTED: similar to signaling inositol polyphosphate 5
          phosphatase SIP-145 n=1 Tax=Pan troglodytes
          RepID=UPI0000E1FA37
          Length = 177

 Score = 95.3 bits (236), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 29/64 (45%), Positives = 40/64 (62%)

Query: 6  VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY+  +YTYR+   E   ++
Sbjct: 5  WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64

Query: 66 AETA 69
           + A
Sbjct: 65 VQDA 68


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score = 95.3 bits (236), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 9/112 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVL-----YQGYIYTY 54
           ++    + G  +R      L A  L  G++L+R+SE+ PG Y L V      +   I  Y
Sbjct: 108 LEVEGWFFGSCTRSEAIMRLQADNLPKGTFLVRESETRPGTYALTVRETDHGHPPTIKNY 167

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           RV +T+ GS   E      +R F  V +++        G+ + L  P  K +
Sbjct: 168 RVDKTKDGS---ELFFINPQRKFNTVIDVVKFHTSQPGGLCSKLLKPCPKQT 216


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score = 94.9 bits (235), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 6/105 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     Y G + R +    LL+ G  GS+L+R S S PG Y L +  +  +  Y + +T+
Sbjct: 95  LKKYDWYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGDYTLSLHNETSLKHYHIKKTK 154

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
             ++         K  F  + +L+  ++K   G+   L+    + 
Sbjct: 155 NCTFYI------LKEEFSNLPSLVEHYKKVSGGLPRTLKDACSQK 193


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score = 94.9 bits (235), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 14/120 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV--LYQGY----IYTY 54
           +D    Y   ++R   E+LL +   +G +++RDS S PG+Y + +   + G        Y
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHY 300

Query: 55  RVSQTETG--SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            + +T T    +         K  F  +  +I   +    G+VT L+YPV       P  
Sbjct: 301 HIKETTTSPKKYYL-----AEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score = 94.6 bits (234), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 24/123 (19%), Positives = 49/123 (39%), Gaps = 14/123 (11%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
                +H  I+RE    ++   G +DG YL+R+S++ PG + L   +   +  Y++    
Sbjct: 628 QTQPWFHHGINREEANNMMHMQGMVDGLYLVRESQTFPGTFVLTFCHDQRVKHYQIQPNV 687

Query: 59  -TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
             +   +S +      +  F  +  L+  +Q     +   L +P   +  R       R 
Sbjct: 688 IDDKTFYSLDEG----ETKFGDLVQLVEFYQINRGALPHSLTHPCTGAGLR------WRE 737

Query: 118 DSD 120
           D +
Sbjct: 738 DDE 740


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score = 94.6 bits (234), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 12/107 (11%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             Y+G I+R   + LL   G DG +L+RDSE+  G Y + +   G    +RV     G+ 
Sbjct: 311 PWYYGSITRYMCDNLLNQRGHDGDFLIRDSETNVGDYSVSLKAPGRNKHFRV--HVEGAL 368

Query: 65  SAETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSS 106
                  + +R F  +  L+  +Q+       QG    L  P+ K +
Sbjct: 369 YC-----IGQRKFHTLDQLVDHYQRAPIYTNKQGEKLYLVRPLPKPT 410


>UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A9JR87_DANRE
          Length = 264

 Score = 94.2 bits (233), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 44/103 (42%), Gaps = 12/103 (11%)

Query: 6   VYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYQG-----YIYTYRVSQT 59
                +S+   E+LL+      GS+L+R+SE+ PG Y L V   G      +  YR+S  
Sbjct: 94  WQFVGLSKRKSEELLMLPHNQPGSFLIRESETFPGNYTLSVRKSGSQERASVKHYRISCI 153

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           + G +            FR + ++I+ +     G+   L  P 
Sbjct: 154 DNGWFYISPGL-----TFRTLSDMIAHYSV-SDGLCCTLGEPC 190


>UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925DBE
          Length = 249

 Score = 94.2 bits (233), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 32/125 (25%), Positives = 54/125 (43%), Gaps = 10/125 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  +HG ++R T E LLLA G++G+YL+R+S S PG Y + V  Q  I  Y +    
Sbjct: 49  IEDLPWFHGDMTRNTSEALLLANGVEGTYLVRNSASDPGSYTVSVRCQSSIKHYSLRHNV 108

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPVEKSSGRGPQAPTG 115
                 +      + F+    +LI  F+       + G     +YP  K           
Sbjct: 109 H-----DNTYTFGRGFYDSYNDLIDHFECKPVLTGETGEPVIFRYPYIKDVPEPSSYEKV 163

Query: 116 RRDSD 120
            R ++
Sbjct: 164 LRHAE 168


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score = 94.2 bits (233), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 22/91 (24%), Positives = 39/91 (42%), Gaps = 7/91 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     Y+G+I+R   EKLL +   +G++L+R SES PG + L V     +  ++V +  
Sbjct: 55  MKNHDWYYGRITRADAEKLL-SNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDA 113

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
              +            F  +  L+   +   
Sbjct: 114 QSKFFL------WVVKFNSLNELVEYHRTAS 138


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score = 94.2 bits (233), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 25/130 (19%), Positives = 56/130 (43%), Gaps = 14/130 (10%)

Query: 1   MDAVTVYHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLY------QGYIYT 53
           +++   Y GKI R   E+L L +    G++L+R+ E+    + L +         G +  
Sbjct: 133 IESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKH 192

Query: 54  YRVSQ-TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK-SSGRGPQ 111
           Y++ +      +   T     +R FR ++ L+  +     G+   L +P  + +  R   
Sbjct: 193 YKIKRLDHDQGYFITT-----RRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDL 247

Query: 112 APTGRRDSDI 121
           +   +++ +I
Sbjct: 248 SHDTQQNWEI 257


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score = 93.8 bits (232), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 7/124 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     Y   +SR   ++LLL+   + G++L+R SES  G Y L V  Q  +  YRVS  
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMA 174

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
             GS   +       R F  ++ L++ ++   + I  PL  P              R  S
Sbjct: 175 ADGSLYLQKG-----RLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDV-WERPHS 228

Query: 120 DICL 123
           +  L
Sbjct: 229 EFAL 232


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 93.4 bits (231), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 27/121 (22%), Positives = 47/121 (38%), Gaps = 17/121 (14%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           ++  +H  ++    E+LL     DGS+L+R SES  G + + V   G +   ++      
Sbjct: 2   SLKWFHSSLNGSQAEELLTPL-ADGSFLVRPSESKHGDFTISVKCNGKVTHIKIQNDGDS 60

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
                         F  +++L+S ++      K   G+   L YPV     R     T R
Sbjct: 61  FLLI-----GSPDPFPTLESLVSHYRNTPNSIKEKSGVFIELLYPV-----RSTDPTTER 110

Query: 117 R 117
            
Sbjct: 111 W 111



 Score = 82.2 bits (202), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 6/85 (7%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               YHG I  +  E++LL+ G  GSYL+R+S+S PG + L V     +    +S     
Sbjct: 108 TERWYHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQVIISC-RNK 166

Query: 63  SWSAETAPGVHKRFFRKVKNLISAF 87
            +  ++ P      F  ++ LI  +
Sbjct: 167 KYEIKSGPS-----FASLQELIEYY 186


>UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Tetraodontidae RepID=Q4SUZ3_TETNG
          Length = 232

 Score = 93.4 bits (231), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 49/113 (43%), Gaps = 14/113 (12%)

Query: 5   TVYHG----KISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
            VYHG     + R+  E+LL   G   GS+++R+S    G Y L V Y+  +  YR+ + 
Sbjct: 80  KVYHGWLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVKYR-SVKHYRIYRL 138

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
           +   +            F+ ++++I+ +     G+   L  P   +S   P  
Sbjct: 139 DNSWYYIS-----PSLTFQCLEDMINHY---CDGLCCALTSPCLSASLPAPPT 183


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score = 93.4 bits (231), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 29/133 (21%), Positives = 52/133 (39%), Gaps = 16/133 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVL-----YQGYIYTY 54
           ++    +   I+R+  E+ LLA G   G++L+R+SE++ G Y L V      +   I  Y
Sbjct: 172 LETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDVIKHY 231

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-- 112
           ++   + G +         +  F  + ++I  +Q               +S    P    
Sbjct: 232 KIRSLDNGGYYIS-----PRITFPCISDMIKYYQTNYMKTWVVAAEIAPRSPHLAPATTS 286

Query: 113 ---PTGRRDSDIC 122
              P G   SD C
Sbjct: 287 RLSPEGSCWSDFC 299


>UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra magnipapillata
           RepID=UPI00019266B8
          Length = 237

 Score = 93.0 bits (230), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 44/114 (38%), Gaps = 12/114 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  +H  + R   E LLL  G DGSYLLR   +    Y L       +  +++S   
Sbjct: 5   VEDLGWFHSNLDRHQAEALLLHNGQDGSYLLRICTNNENSYVLSCRCANSVKHFQISY-- 62

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGRG 109
            G +            F     L+  F+       + G++T L+YP  +     
Sbjct: 63  DGKYY-----RFGMAIFETFSELVKHFENQPLLGGESGVLTLLKYPYPRRVNEP 111


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score = 93.0 bits (230), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 47/111 (42%), Gaps = 11/111 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           +++   +   + R+  +KLLL      G++L+R SE  P  Y L V         ++  Y
Sbjct: 157 VNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHY 216

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           R+   + G +   T      + F  ++ L+ A+ K   G+   L  P  K 
Sbjct: 217 RIKPLDNGGYYIATN-----QTFPSLQALVMAYSKNALGLCHILSRPCPKP 262


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score = 91.9 bits (227), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 40/103 (38%), Gaps = 9/103 (8%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               +HGKI+ +  EK+LL  G    +L+R+S   PG Y L VL    +    +     G
Sbjct: 111 TERWFHGKITGKEAEKMLLERGKPDCFLVRESVHRPGSYVLSVLTGEQVAHIMIHGKPNG 170

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQK----PDQGIVTPLQYP 101
            +            F  +K LI  +         G +  L+ P
Sbjct: 171 MYDVGGG-----HQFSSLKELIDFYTNTPMVEKNGGLVSLKQP 208



 Score = 88.0 bits (217), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 43/116 (37%), Gaps = 15/116 (12%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  ++    EKLL   G+ GS+L R S S PG + L V     +   R+  TE     
Sbjct: 8   WFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGDEVTHIRIQNTE----- 62

Query: 66  AETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPVEKSSGRGPQAPTG 115
            E         F  +  L++ +       +   G +  L+YP+       P     
Sbjct: 63  -EFLDLYGGEKFATLSELVTYYMENEGQLREKNGDLIELKYPL---ISEDPTTERW 114


>UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RJ03_TRIAD
          Length = 235

 Score = 91.9 bits (227), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 6/99 (6%)

Query: 5   TVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
             Y+G++ R   EKLLL+  +DG   +L+R SES  G + L V     I  +R+ + +  
Sbjct: 137 PYYYGEMKRADAEKLLLSESVDGCNLFLIRKSESYKGEFALSVKENDDILHFRLPELQQD 196

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           S             F  + +L+  F     G+   L  P
Sbjct: 197 SLIIARKYIE----FISLDDLVQYFSLNSNGLCAKLTKP 231



 Score = 72.2 bits (176), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 21/105 (20%), Positives = 43/105 (40%), Gaps = 11/105 (10%)

Query: 6   VYHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            +   +SR   +K+L       GS+ +R S++  G + L V     I  Y + +  +G +
Sbjct: 16  WFFTGLSRGDIDKMLYKKVNQQGSFAVRPSDTYLGDFSLSVKDGKRICHYLIRRLCSGHF 75

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
                    +  F  + +L++ +   + G+      P   SSG+ 
Sbjct: 76  LISV-----RVTFPSLLSLVTYYVDDNNGL-----KPCVDSSGKE 110


>UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 n=1 Tax=Monodelphis
           domestica RepID=UPI0000F2B3BE
          Length = 310

 Score = 91.9 bits (227), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 23/103 (22%), Positives = 45/103 (43%), Gaps = 11/103 (10%)

Query: 6   VYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVL-----YQGYIYTYRVSQT 59
             +  ++RE  E LLL  +   GS+L+R+S++  G Y L V       +  +  YR+ + 
Sbjct: 134 WLYEGLNREKAEDLLLLPSNHGGSFLIRESQTRRGAYSLSVRLSRPTSRDVVRHYRIHRL 193

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           E G +         +  F  ++ L+  + +    + + L  P 
Sbjct: 194 ENGWFYIS-----PRLTFPSLQALVEHYTEMADDLCSLLVEPC 231


>UniRef50_UPI000180B667 PREDICTED: similar to GF12762 n=1 Tax=Ciona intestinalis
           RepID=UPI000180B667
          Length = 886

 Score = 91.5 bits (226), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 24/99 (24%), Positives = 48/99 (48%), Gaps = 7/99 (7%)

Query: 6   VYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-ETGS 63
            +H K++R   E  L   G + G +L+R+S +VPG + L + + G    ++++ +  +G 
Sbjct: 43  WFHEKLTRGNAEFNLKKYGNEQGMFLVRESINVPGSFVLSLTHNGKAQHFQINTSIHSGC 102

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           +S +  P      F  +  LI+ ++    G+ T L    
Sbjct: 103 FSIDNGPP-----FVGLDQLIAFYRAASNGLPTILTRSC 136



 Score = 88.8 bits (219), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 21/104 (20%), Positives = 45/104 (43%), Gaps = 6/104 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
             +  H  + R    ++L  +G +DGS+++R S+  PG + L + +   +Y Y +     
Sbjct: 318 QTSWLHDAMDRFKAVEMLEMSGLVDGSFMVRLSKRNPGQHVLTMAHDKTVYNYEIRNRGN 377

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
             +  +  P      F  ++ L+  + +   G+   L  PV  +
Sbjct: 378 QWYYIDDGP-----LFTSLEYLVDYYCRCSDGLPAELTSPVPSA 416



 Score = 88.4 bits (218), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 6/101 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
             +  H  + R    ++L  +G +DGS+++R S+  PG + L + +   +Y Y +     
Sbjct: 475 QTSWLHDAMDRFKAVEMLEMSGLVDGSFMVRLSKRNPGQHVLTMAHDKTVYNYEIRNRGN 534

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
             +  +  P      F  ++ L+  + +   G+   L  P 
Sbjct: 535 QWYYIDDGP-----LFTSLEYLVDYYCRRSDGLPAELTSPC 570


>UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=Euteleostomi
           RepID=GRB7_HUMAN
          Length = 532

 Score = 91.5 bits (226), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 23/101 (22%), Positives = 45/101 (44%), Gaps = 4/101 (3%)

Query: 6   VYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-TETGS 63
            +HG+ISRE  ++L+   G +DG +L+R+S+  P  + L + +   +  Y +    E G 
Sbjct: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
                  G  +  F  +  L+   Q     +   L++   +
Sbjct: 491 LYFSMDDGQTR--FTDLLQLVEFHQLNRGILPCLLRHCCTR 529


>UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QLS5_SCHMA
          Length = 801

 Score = 91.1 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 26/105 (24%), Positives = 45/105 (42%), Gaps = 10/105 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           ++A   Y   ISR+  E+LLL  G + G++L+R SE+  G   L V          +  Y
Sbjct: 393 VEAEDWYFRSISRKDSERLLLLKGNIRGTFLVRASETTNGALSLSVRDTEQQRGETVKHY 452

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
           ++ Q+              K+ F  +K+L+  +     G+   L 
Sbjct: 453 KIKQSSE----TNDVYITTKQVFPDLKSLVIHYSNQADGLCCCLT 493


>UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2_HUMAN
          Length = 261

 Score = 90.7 bits (224), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 11/106 (10%)

Query: 3   AVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQ-----GYIYTYRV 56
           +    +  +SRE  E+LLL  G   G++L+R+S++  G Y L V          I  YR+
Sbjct: 91  SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
              + G           +  F  ++ L+  + +    I   L+ P 
Sbjct: 151 HCLDNGWLYIS-----PRLTFPSLQALVDHYSELADDICCLLKEPC 191


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score = 90.7 bits (224), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 29/125 (23%), Positives = 52/125 (41%), Gaps = 18/125 (14%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVP--GVYCLCVLYQGYIYTYRVSQTE 60
           +   Y GKISR+  E+ L++   DG++++RDSES P  G + L V ++  +  +++    
Sbjct: 59  SHPWYVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKILTDL 118

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD----QGIVTPLQYPV----EKSSGRGPQA 112
            G +            F  + +L+   +       Q IV  L  P     + +    P  
Sbjct: 119 AGKYFL------WVVKFTSINDLVDYHKDNSVSRTQEIV--LNEPCVPIEDANQRPQPAM 170

Query: 113 PTGRR 117
              R 
Sbjct: 171 QQSRE 175


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score = 90.3 bits (223), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 25/103 (24%), Positives = 37/103 (35%), Gaps = 11/103 (10%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++       +
Sbjct: 326 KWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGD-FF 384

Query: 65  SAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPV 102
                       F  +  L+  +      K   G    L+ P+
Sbjct: 385 DLYGGE-----KFATLPELVQYYMENGELKEKNGQAIELKQPL 422


>UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y4_9METZ
          Length = 853

 Score = 89.9 bits (222), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 26/97 (26%), Positives = 46/97 (47%), Gaps = 5/97 (5%)

Query: 8   HGKISRETGEKLL-LATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           H  IS ++ EK+L +    DG++L+R+S S    Y L + +   I  +R+S+   GS S 
Sbjct: 362 HVAISPDSVEKVLEMYNKEDGTFLIRESRSSENSYTLSLCHNQRIKNFRISRDTDGSLSL 421

Query: 67  ETAPGV----HKRFFRKVKNLISAFQKPDQGIVTPLQ 99
           +   G       + F  +  L+   +    G+ T L+
Sbjct: 422 KDPAGSTAEQPIKSFPSMAALVEHHKTEKDGLPTHLK 458


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score = 89.5 bits (221), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 8/90 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+    Y G+ISRE  E LLL  G +G +L+RDSES PG   + +        ++V    
Sbjct: 296 MEQQPWYFGRISRERAEDLLL-HGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQN-- 352

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP 90
                 +    +  R F  +  LI+ +   
Sbjct: 353 -----VDGLLKIGNRTFVDMNALINHYTTS 377


>UniRef50_B7QCJ2 Growth factor receptor-bound protein, putative n=1 Tax=Ixodes
           scapularis RepID=B7QCJ2_IXOSC
          Length = 203

 Score = 89.5 bits (221), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 24/99 (24%), Positives = 45/99 (45%), Gaps = 5/99 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           A   +HG + RET   LLL     DG++L+R S +    + LC L+ G +   ++     
Sbjct: 98  AQPWFHGSLQRETATLLLLKHATEDGAFLVRRSLTRLDTFVLCYLFHGEVRHVQIQTLGE 157

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY 100
             +S ++     +  F  ++ L+  +Q     ++T L  
Sbjct: 158 DCFSIDSG----RTKFSCLQQLVQFYQLNQGNLLTRLGQ 192


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score = 89.5 bits (221), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 7/85 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             Y+GK++R   E  L   G +G +L+RDSES P  + + +  QG    ++V        
Sbjct: 84  PWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLK----- 138

Query: 65  SAETAPGVHKRFFRKVKNLISAFQK 89
             ET   + +R F  ++ L+  ++K
Sbjct: 139 --ETVYCIGQRKFSTMEELVEHYKK 161


>UniRef50_C4QKJ6 Proto-oncogene tyrosine-protein kinase abl1, putative n=1
           Tax=Schistosoma mansoni RepID=C4QKJ6_SCHMA
          Length = 316

 Score = 89.5 bits (221), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 28/74 (37%), Positives = 39/74 (52%), Gaps = 1/74 (1%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG +SR+ GE LL  +G+ GS+L+R SES PG   + V + G +Y YR+SQ   G 
Sbjct: 239 YSWYHGAVSRQAGEHLL-RSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGL 297

Query: 64  WSAETAPGVHKRFF 77
                        F
Sbjct: 298 VFFSRIEQYSTVVF 311


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score = 89.2 bits (220), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 26/107 (24%), Positives = 39/107 (36%), Gaps = 11/107 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPV 102
              +            F  +  L+  +      K   G    L+ P+
Sbjct: 61  D-FFDLYGGE-----KFATLPELVQYYMENGELKEKNGQAIELKQPL 101


>UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E4312
          Length = 350

 Score = 89.2 bits (220), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 23/104 (22%), Positives = 46/104 (44%), Gaps = 8/104 (7%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +   +HG +SR+  ++L+   G +DG +L+R+S+     + L + +Q  I  Y V   E 
Sbjct: 246 SQPWFHGGVSRKEAQRLIEKQGLVDGMFLIRESQQHGQCFVLSLSHQLKIKHYLVIPCED 305

Query: 62  G---SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           G    ++ +         F  +  L+   Q     +   L++P 
Sbjct: 306 GGRKYFTIDDGL----TLFIDLLQLVEFHQINKGILPVCLKHPC 345


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score = 88.4 bits (218), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 22/84 (26%), Positives = 43/84 (51%), Gaps = 7/84 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            Y+GK++R   E +L   G+DG +L+RDSES+P  + + +        ++V     G + 
Sbjct: 236 WYYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISLKALYKNKHFKVL-LNDGFFC 294

Query: 66  AETAPGVHKRFFRKVKNLISAFQK 89
                   +R F  +++L+  ++K
Sbjct: 295 I------GQRKFSTMEDLVEHYKK 312


>UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_DROER
          Length = 220

 Score = 88.4 bits (218), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 25/102 (24%), Positives = 37/102 (36%), Gaps = 11/102 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++       + 
Sbjct: 52  WFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGD-FFD 110

Query: 66  AETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPV 102
                      F  +  L+  +      K   G    L+ P+
Sbjct: 111 LYGGE-----KFATLPELVQYYMENGELKEKNGQAIELKQPL 147


>UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (Fragment) n=1
           Tax=Ixodes scapularis RepID=B7P7A9_IXOSC
          Length = 358

 Score = 88.4 bits (218), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 26/113 (23%), Positives = 50/113 (44%), Gaps = 8/113 (7%)

Query: 5   TVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             ++  +SRE   +LLL  G +DG +L+R S S PG + L   ++G ++  ++   E   
Sbjct: 241 PWFYSGMSREEATQLLLRHGTVDGVFLVRQSLSKPGTFVLSYAFRGTVHHVQIISVEEKD 300

Query: 64  ---WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP 113
              +S ++     +  F  +  L+  +Q     + T L + +     R    P
Sbjct: 301 QLCYSLDSG----RTKFYDLLQLVEFYQLNLSYLPTKLTHFLVHQPRRRTTPP 349


>UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2C7_MONBE
          Length = 592

 Score = 88.4 bits (218), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 29/104 (27%), Positives = 45/104 (43%), Gaps = 9/104 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + YHG ISRE   + L     DG++LLR S +    Y + +   G I   RV+ T  G +
Sbjct: 432 SYYHGTISREEAVRRLQEVNTDGAFLLRLSATQKDAYTISLQSNGEIKHIRVTNTSNGGY 491

Query: 65  SAETAPGVHKRFFRKVKNLISA-----FQKPDQGIVTPLQYPVE 103
           +     G  K  F  + +LI A      +         L +P++
Sbjct: 492 AL----GKSKEEFESIWDLIEAQLDKSLKSTKGDQAVQLVHPLK 531


>UniRef50_Q29CU6 GA13993 n=10 Tax=Neoptera RepID=Q29CU6_DROPS
          Length = 297

 Score = 88.4 bits (218), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 27/126 (21%), Positives = 52/126 (41%), Gaps = 8/126 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  + Y G +SR+   ++L+     G +L+RDS S+ G Y LCV     +  Y +++ + 
Sbjct: 8   DKSSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQ 67

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVEKSSGRGPQAPT--GRRD 118
                +    +  + F  +  L++ +         TPL+ P +K   +        G   
Sbjct: 68  ---QDQIVYRIGDQSFDNLPKLLTFYTLHYLD--TTPLRRPAQKKVEKVVGKFDFVGSDQ 122

Query: 119 SDICLN 124
            D+   
Sbjct: 123 DDLPFQ 128


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
          Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 88.4 bits (218), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 22/87 (25%), Positives = 40/87 (45%), Gaps = 7/87 (8%)

Query: 3  AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
          A+  +   I+R+  E LL+    +G++L+R SES  G+Y L V Y   +  +R+ Q   G
Sbjct: 11 AMAWFFPTITRKNAELLLMQE-RNGAFLVRRSESSEGLYSLSVKYNESVQHFRILQDTAG 69

Query: 63 SWSAETAPGVHKRFFRKVKNLISAFQK 89
           +            F  +  L+  ++ 
Sbjct: 70 KFHL------WIVKFPSLDALVDYYRT 90


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score = 88.0 bits (217), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 20/85 (23%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             Y+G ++R   E  L   G++G +L+RDSES P  + + +   G    ++V        
Sbjct: 284 EWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQ------- 336

Query: 65  SAETAPGVHKRFFRKVKNLISAFQK 89
             +    + +R F  +  L+  ++K
Sbjct: 337 LVDNVYCIGQRRFHTMDELVEHYKK 361


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score = 88.0 bits (217), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 23/122 (18%), Positives = 48/122 (39%), Gaps = 10/122 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCV---LYQGYIYTYRVS 57
           ++    Y G +SR+  E LL     +G +++R S S  G+Y L +   + Q ++  Y + 
Sbjct: 405 LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIK 463

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ-YPVEKSSGRGPQAPTGR 116
           Q     +         K     + +LI+  +    G+   L+  P ++           +
Sbjct: 464 QNARCEYYLS-----EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDK 518

Query: 117 RD 118
            +
Sbjct: 519 WE 520


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score = 88.0 bits (217), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 36/109 (33%), Gaps = 14/109 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHG I R   ++LL      G +L+R+S   PG Y L V   G    + +    
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKKQ---GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQ--- 508

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI----VTPLQYPVEKS 105
                 +         F  +  LI       Q I       L  P+ K 
Sbjct: 509 ----YVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKD 553


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score = 87.6 bits (216), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 27/112 (24%), Positives = 49/112 (43%), Gaps = 12/112 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +   + Y+G I+R   + +L   G DG +L+RDSE+  G Y + +   G    +RV   +
Sbjct: 443 LAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQ 502

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSSG 107
                      + +R F  +  L+  +Q+       QG    L   + K++G
Sbjct: 503 NMY-------CIGQRKFHSLDQLVDHYQRAPIYTNKQGEKLYLVRSLPKANG 547


>UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X6G9_CULQU
          Length = 109

 Score = 87.6 bits (216), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 25/105 (23%), Positives = 39/105 (37%), Gaps = 12/105 (11%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
              +H  +S    EKLLL  G DGS+L R S S PG + L V     +   ++       
Sbjct: 2   ERWFHPSVSGVDAEKLLLERGFDGSFLARLSSSNPGAFTLSVRRGKEVTHIKIQNNGD-F 60

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPV 102
           +            F  +  L+  +       K   G +  L+ P+
Sbjct: 61  FDLYGGE-----KFATLSELVQYYMENGGQLKEKNGQIIELKQPL 100


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score = 87.2 bits (215), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 28/135 (20%), Positives = 54/135 (40%), Gaps = 13/135 (9%)

Query: 3   AVTVYHGKISRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           A   YHG++ R+  ++LL    G DGS+++R+S +  G   L  +Y G +   R+   + 
Sbjct: 565 AEKWYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCTLSFMYHGRVTHCRIHSQQN 624

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSSGRGP-----Q 111
              +      VH   F  + +L+  +Q+             L  PV + +          
Sbjct: 625 NGHT--YFYLVHALLFDSLYSLVWHYQRYPLRNAKMNFELLLTEPVPQPNAHANKEWYHD 682

Query: 112 APTGRRDSDICLNAP 126
           + T     ++ +  P
Sbjct: 683 SMTRTDAENVLMRIP 697



 Score = 71.1 bits (173), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 22/104 (21%), Positives = 40/104 (38%), Gaps = 10/104 (9%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSES---VPGVYCLCVLYQGYIYTYRVSQTET 61
             YH  ++R   E +L+    DG++L+R   S       + +     G I   R+ Q   
Sbjct: 678 EWYHDSMTRTDAENVLMRIPRDGAFLVRKCRSDDPSVTSFAISFRADGKIKHCRIKQESR 737

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
             +    A       F  + ++IS ++K        L++P  K 
Sbjct: 738 -LFVIGNA------TFETLCDVISFYEKNPLYRKMKLKHPATKE 774


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score = 87.2 bits (215), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 25/108 (23%), Positives = 41/108 (37%), Gaps = 14/108 (12%)

Query: 6   VYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQ-----GYIYTYRV-SQ 58
              G  SR+  EK L+A G++ G +++RD    PG + L V         ++  YR+   
Sbjct: 7   WDFGMCSRQDAEKKLMAIGINKGQFIVRD--RDPGTFELSVRDNNPQKGDHVKHYRIWKM 64

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
               S+            F  V  L+  +Q    G+   L     K +
Sbjct: 65  DGGNSFFI-----FQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKEN 107


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score = 87.2 bits (215), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 20/83 (24%), Positives = 38/83 (45%), Gaps = 6/83 (7%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            Y G + R   E+ L     +G +L+R SE+  G Y + +   G I  ++V+    G + 
Sbjct: 316 WYFGNMKRADAEQRLQDRADNGEFLVRGSETSSGDYSISMKMPGRIRHFKVNTLPNGVF- 374

Query: 66  AETAPGVHKRFFRKVKNLISAFQ 88
                G+ +R F  +  L+  ++
Sbjct: 375 -----GIGQRKFDSMDALLEHYK 392


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score = 86.8 bits (214), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQ-GYIYTYRVSQTETGSW 64
            YHGK+ R   E+ L   G  GSYL+R+S+  PG + L  L Q   +  +R+       +
Sbjct: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGI-VTPLQYPVEKSSGRGPQAPTGRR 117
                  +  R F  + +LI  +      +    L YPV       P+    RR
Sbjct: 241 -------IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPV-----APPEPVEDRR 282



 Score = 78.4 bits (192), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 24/98 (24%), Positives = 45/98 (45%), Gaps = 6/98 (6%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HGKIS++    LL+  G   S+L+R S++ PG Y L       I  +++  T    + 
Sbjct: 351 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
                 +  R++  + ++I  ++K        L+ PV 
Sbjct: 411 ------MGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVP 442


>UniRef50_A7S295 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7S295_NEMVE
          Length = 642

 Score = 86.8 bits (214), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 44/115 (38%), Gaps = 11/115 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     +HG+IS +    L+   G  DG +L+R+S SV  VY L       ++  ++ Q 
Sbjct: 529 LAEEFWFHGRISHDEALVLMKREGFEDGLFLVRESCSVSDVYVLTFCMNKKVFHCQLVQD 588

Query: 60  ----ETGSWSAETAPGVHKRFFRKVKNLISAFQKPD-QGIVTPLQYPVEKSSGRG 109
                   +  +  P      F  +  LI  +Q+    GI   L  P      R 
Sbjct: 589 IGPGSKMYYRLDKGPA-----FPSILELIRYYQRKTVNGISVALGRPCTVKRRRN 638


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score = 86.5 bits (213), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 23/104 (22%), Positives = 38/104 (36%), Gaps = 12/104 (11%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           V  +H  IS    E +L + G+ GS+L R S    G + L V     +   R+  T    
Sbjct: 2   VRWFHRDISGLDAESVLKSRGVHGSFLARPSRKNQGDFSLSVRVGELVTHIRIQNTGD-F 60

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYP 101
           +            F  +  L+  +       +   G +  L+YP
Sbjct: 61  YDLYGGE-----KFATLSELVEYYTAENGILQDKDGTIIELKYP 99



 Score = 79.9 bits (196), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 24/112 (21%), Positives = 43/112 (38%), Gaps = 19/112 (16%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY---------IYT 53
               YHG +S    EKLL      G++L+R+S S PG + L VL +           +  
Sbjct: 107 TERWYHGHLSGPNAEKLLWERDEPGTFLVRESLSKPGDFVLSVLTEEKSKASSGGRRVSH 166

Query: 54  YRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD----QGIVTPLQYP 101
            ++       ++        K  F  + +L+  +++       G    L+ P
Sbjct: 167 IKIMCQND-RYTV-----GGKEMFDTLADLMEHYKRKGIEEMSGTWVHLKQP 212


>UniRef50_UPI000180BA50 PREDICTED: similar to growth factor receptor-bound protein 10 n=1
           Tax=Ciona intestinalis RepID=UPI000180BA50
          Length = 553

 Score = 86.5 bits (213), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 20/106 (18%), Positives = 44/106 (41%), Gaps = 8/106 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTY---RVS 57
              T ++GKI+RE   + L   G +DG +L+RDS ++PG   + + +          ++ 
Sbjct: 447 QTQTWFYGKITREEATEELHRNGNVDGLFLVRDSHTIPGGIVVTLCHNQKSRHIPITQIE 506

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
           +     ++A+      +  F  +  L+   +     +   L +   
Sbjct: 507 RNGQNFYTADNG----ETRFVDMIQLVDFHRLNKGSLPCLLLHECS 548


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score = 86.5 bits (213), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 8/102 (7%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             YHG + R++ E  L A    GSYL+R+SE  PG Y L  L Q  I  +RV+      +
Sbjct: 67  EWYHGCLDRQSAELRLNAADKPGSYLVRESERKPGSYVLSYLGQRGINHFRVTAVCGDFY 126

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVT-PLQYPVEKS 105
                  V  R F+ +  LI  +      +    LQYP    
Sbjct: 127 -------VGGRQFQTLPELIGYYTHISNILKNERLQYPAPPP 161



 Score = 76.8 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 22/116 (18%), Positives = 45/116 (38%), Gaps = 11/116 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +HG +S+E   + L   G  G +L+R+S+  PG Y L       I  +R+ + + 
Sbjct: 233 EGKVWFHGNVSKEEAAETLWKDGDIGGFLIRNSDKNPGDYSLSFRGPNTIQRFRIQKQQR 292

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPD--QGIVTPLQYPVEKSSGRGPQAPTG 115
                        R++  +  ++  ++K +   G    L+ P      +     T 
Sbjct: 293 QYVM-------GGRYYNSLDAIVDHYKKEEIIDGF--KLRDPTAPKKFKNQTTSTE 339


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score = 86.5 bits (213), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 14/106 (13%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           V  +H  IS    EKLLL  G+ GS+L R S+S PG + L V     +   ++  T    
Sbjct: 2   VRWFHPNISGIEAEKLLLTRGVHGSFLARPSKSNPGDFTLSVRRNDEVTHIKIQNTGD-Y 60

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGI-------VTPLQYPV 102
           +         ++       L+  +    QG+       V  L+YP+
Sbjct: 61  YDLYGGEKFARK-----PELVQYYT-EQQGLLREKNSNVIELKYPL 100



 Score = 74.9 bits (183), Expect = 8e-13,   Method: Composition-based stats.
 Identities = 30/146 (20%), Positives = 48/146 (32%), Gaps = 52/146 (35%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQ------GYIYTYRV 56
           +   YHG ++ +  EKLL   G  GS+L+R+S+S PG + L VL        G   T R 
Sbjct: 107 SERWYHGHLTGKEAEKLLTEKGKPGSFLVRESQSKPGDFVLSVLTNEDKMETGDPQTSRD 166

Query: 57  SQTE-------------------------------------TGSWSAETAPGVHKRFFRK 79
            + +                                      G +            F  
Sbjct: 167 PRDDPLPGGQPACPRFACRAGPSWEPCALEPHRASVALLQPDGKYDVGGGE-----RFDT 221

Query: 80  VKNLISAFQK----PDQGIVTPLQYP 101
           + +L+  ++K       G V  L+ P
Sbjct: 222 LTDLVEHYKKNPMVEKSGAVVHLKQP 247


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score = 86.1 bits (212), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 7/82 (8%)

Query: 10  KISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETA 69
           K++R+  E+LL   G DG++L+R+SE  PG Y L V +   +  ++V +   G +     
Sbjct: 27  KVTRDGAEELLKNDG-DGAFLIRESEGTPGDYSLSVKFVDGVQHFKVLRDGAGKYFL--- 82

Query: 70  PGVHKRFFRKVKNLISAFQKPD 91
                  F  +  L+   +   
Sbjct: 83  ---WVVKFNSLNQLVEYHRTSS 101


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score = 86.1 bits (212), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 23/118 (19%), Positives = 41/118 (34%), Gaps = 8/118 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   + G ISR    + L A G   G++L+R SE     Y L V     +  Y++ + 
Sbjct: 73  VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
             G      A       F  +  L++  +   Q +   L+             P    
Sbjct: 133 AGGRLHLNEA-----VSFLSLPELVNYHR--AQSLSHGLRLAAPCRKHEPEPLPHWDD 183


>UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Ciona intestinalis
           RepID=UPI000180C238
          Length = 295

 Score = 85.7 bits (211), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 44/111 (39%), Gaps = 11/111 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  + Y G +SR+  +  LL     GS+L+RDS + PG Y L V     +  Y +++   
Sbjct: 10  DEDSWYFGMVSRKDSQNKLLHQ-KHGSFLVRDSTTCPGDYVLSVSENSKVSHYIINKQ-- 66

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKP-DQGIVTPLQYPVEKSSGRGPQ 111
                E    +  + F  +  L+  ++        T L  P+ K       
Sbjct: 67  -----ENRLKIGDQMFDSMPELLDFYKVHYLD--TTTLIEPIPKPIKPQQT 110


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score = 85.7 bits (211), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 23/122 (18%), Positives = 48/122 (39%), Gaps = 8/122 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   + GK++R      L++   + GS+L+R SES    Y L V  +     +++ QT
Sbjct: 129 VESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQT 188

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
               +  +         F  +  +I  +Q     I   L  P  +        P+   + 
Sbjct: 189 GD-QFYVDALF-----KFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVPPPST-DEW 241

Query: 120 DI 121
           ++
Sbjct: 242 EL 243


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score = 85.7 bits (211), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 7/86 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +  KISR   E LL++ G+ G +++R S++  G + + V ++  +  ++V +   GS+ 
Sbjct: 73  WFDEKISRHEAENLLMSKGV-GCFVVRASQNSHGDFSISVRHEDDVQHFKVMRDSKGSYY 131

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPD 91
             T        F  +  L+  ++   
Sbjct: 132 LWT------EKFHSLNKLVDYYKTSS 151


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score = 85.3 bits (210), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 17/118 (14%)

Query: 3   AVTVYHGKI--SRETGEKLLLA--TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS- 57
           +   +HGK+   R   E LL       DG++L+R+SE+  G Y L    QG +   R+  
Sbjct: 592 SEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRESETFVGDYSLSFWRQGKVNHCRIRS 651

Query: 58  ---QTETGSWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKSSGRG 109
              + +T  +  +T        F  + +LI+ ++      Q  +  L+ PV + +   
Sbjct: 652 KQDKGQTKYYLIDTNS------FDSLYSLITYYRSHPLRSQEFLIVLKEPVPQPNKHE 703



 Score = 79.9 bits (196), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 21/104 (20%), Positives = 42/104 (40%), Gaps = 7/104 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    Y   ++R   E++L     DG++L+R SE     Y +    +  I   R+     
Sbjct: 703 EGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRPSERGANSYAISFRAEKKIKHCRIKV--D 760

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           G   A     +   +F  + +LI+ +++        L +PV + 
Sbjct: 761 GRLYA-----IGSVYFESLVDLITYYERHPLYKKIRLCHPVNEE 799


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score = 85.3 bits (210), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 8/106 (7%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHG++ R T E+ L      GSYL+R+S+  PG Y L  L +  I  +R++      + 
Sbjct: 77  WYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRITAVCGDYY- 135

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVT-PLQYPVEKSSGRGP 110
                 +  R F  + +L++ +      +    L +P         
Sbjct: 136 ------IGGRQFNSLMDLVAYYTHCSDLLKKERLIHPTPPPEPVND 175



 Score = 62.6 bits (151), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 19/87 (21%), Positives = 38/87 (43%), Gaps = 8/87 (9%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + +H  +++     +L+  G  GS+L+R S++ PG Y L       I  +R+ +   G  
Sbjct: 245 SWFHPNVTKSEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQRFRIEK--KGVR 301

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPD 91
                     R F  +  +I+ ++K  
Sbjct: 302 YLMGG-----RTFECLDAVINRYRKEQ 323


>UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine phosphatase, non-receptor
           type 11 n=1 Tax=Hydra magnipapillata RepID=UPI00019269FE
          Length = 544

 Score = 84.9 bits (209), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 26/115 (22%), Positives = 48/115 (41%), Gaps = 13/115 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     + G+I R   E +L   G  GSYL+R+S + PG + L V +   +  + +    
Sbjct: 119 LSQEKWFFGEIGRGEAELILKQRGEHGSYLVRESRTQPGNFVLSVRHHNSVIEFLLIY-S 177

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISA-------FQKPDQGIVTPLQYPVEKSSGR 108
            G++         +  F  + +LI+         +  DQ I   L  P+  ++ R
Sbjct: 178 DGAFDIAN---TKRLKFPTMTHLINYFITNPLIHKDSDQAI--HLIEPLCDTAER 227



 Score = 80.3 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 28/120 (23%), Positives = 44/120 (36%), Gaps = 13/120 (10%)

Query: 5   TV-YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  +   ++    E LL   G  GSYL R S S PG Y L V  Q  ++ ++++     S
Sbjct: 11  SWGFFANLTVAEAESLLKEKGNHGSYLCRRSTSSPGSYTLSVRRQKEVWNFKITNDGE-S 69

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIV------TPLQYPVEKSSGRGPQAPTGRR 117
           +      G     F  V +LI  +Q      +        L  P+   S   P     + 
Sbjct: 70  FGLYENDG-----FASVPDLIEYYQHNPSKFLDQNNKSVELTEPLIDDSENDPGLSQEKW 124


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score = 84.9 bits (209), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 25/110 (22%), Positives = 42/110 (38%), Gaps = 5/110 (4%)

Query: 3   AVTVYHGKISRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +   +H  ISR+  E LL      DGS+L+R S    G + L    +  +    +    T
Sbjct: 319 SEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRKNRVQHCHIKSRPT 378

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKSSGR 108
              +A     V  + F  + +LI+ +Q            L  PV + +  
Sbjct: 379 NDGTA-KYFLVGPKGFDNLYSLINHYQTNPLKSDKFELMLTEPVPQPNAH 427



 Score = 71.8 bits (175), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 22/103 (21%), Positives = 38/103 (36%), Gaps = 9/103 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSE--SVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            YH  ++R   E++L     D  +L+R          Y +     G I    + +     
Sbjct: 432 WYHENLTRLQAEEMLRRMRKDSYFLVRKRNDGDQNESYAISFRTGGTIKHCVIKKEGR-L 490

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           +   TAP      F  +  LI+ ++K      T L+YP  +  
Sbjct: 491 FMIGTAP------FESLTELIAHYEKNPLYRKTKLKYPCNQDV 527


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 84.2 bits (207), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 26/126 (20%), Positives = 51/126 (40%), Gaps = 14/126 (11%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSE--SVPGV--YCLCVLYQGYIYTYRVSQTE 60
             +H  +SR   E++L    +DG++L+R SE  +  G   Y +    +G +   R+   E
Sbjct: 654 AWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQNTKAGQKNYAISFRAEGKVKHCRIEVDE 713

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           +G +   +A       F  +  L+  ++         L+Y + +   +      G  +SD
Sbjct: 714 SGQYCIGSA------IFDSLTELVQYYEANPLYRRMRLKYAINEDLLKS----LGEAESD 763

Query: 121 ICLNAP 126
                P
Sbjct: 764 DVYYHP 769



 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 25/116 (21%), Positives = 44/116 (37%), Gaps = 16/116 (13%)

Query: 3   AVTVYHGKI--SRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
               +HGK+   R   EKLL     ++G++L+R+S +  G Y L  +  G     R+   
Sbjct: 541 KEKWFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTTFTGDYSLSFVRDGKYNHCRIHTK 600

Query: 60  ETG----SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT---PLQYPVEKSSGR 108
             G     +  +      +  F  +  LI  ++       T    L  PV + +  
Sbjct: 601 SEGGKTRFYLID------QTLFDSIYELIMHYKSNPLKSPTFEQVLAEPVPQQNSH 650


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score = 83.8 bits (206), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 18/87 (20%), Positives = 40/87 (45%), Gaps = 7/87 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             +H  +SR   E LL+   + G +++R S+S PG + + V ++  +  ++V +   G++
Sbjct: 57  KWFHEGLSRHQAENLLMGKEV-GFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNY 115

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPD 91
              T        F  +  L+  ++   
Sbjct: 116 FLWT------EKFPSLNKLVDYYRTNS 136


>UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYM5_SCHMA
          Length = 670

 Score = 83.8 bits (206), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 32/141 (22%), Positives = 56/141 (39%), Gaps = 38/141 (26%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL-------------Y 47
           +     YHG+ISR   E LL  + + GS+L+R+S+   G   LCV+             +
Sbjct: 78  LKDHCWYHGRISRAESESLLSGSPV-GSFLIRESDLYSGGLTLCVVGPACAVGSPDTTEH 136

Query: 48  QGY----------IYTYRVSQ-----TETGSWSAETAPGV---------HKRFFRKVKNL 83
           Q            +  YR+ +     T +   S  + P +            +F  +  L
Sbjct: 137 QNSTVTPPNTMTNVQHYRIVRRPFKATPSNQHSEYSTPLICSKIHYTLDETDWFSSLLEL 196

Query: 84  ISAFQKPDQGIVTPLQYPVEK 104
           +  + +P +G+V  L +PV  
Sbjct: 197 VQFYSEPKRGLVCALLHPVPD 217


>UniRef50_Q9XYM0 Adapter molecule Crk n=8 Tax=Endopterygota RepID=CRK_DROME
          Length = 271

 Score = 83.8 bits (206), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 26/126 (20%), Positives = 51/126 (40%), Gaps = 8/126 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  + Y G +SR+   ++L+     G +L+RDS S+ G Y LCV     +  Y +++ + 
Sbjct: 8   DRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQ 67

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVEKSSGRGPQAPT--GRRD 118
                +    +  + F  +  L++ +         TPL+ P  +   +        G   
Sbjct: 68  ---QDQIVYRIGDQSFDNLPKLLTFYTLHYLD--TTPLKRPACRRVEKVIGKFDFVGSDQ 122

Query: 119 SDICLN 124
            D+   
Sbjct: 123 DDLPFQ 128


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score = 83.8 bits (206), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 26/108 (24%), Positives = 42/108 (38%), Gaps = 12/108 (11%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++  T YHG I+R   E LL +   +GSYL+R+SES    Y L +         R+    
Sbjct: 1089 LEKQTWYHGSITRVEAEDLLRSL-KEGSYLVRNSESAKQDYSLSLKSAKGFMHMRIQIDN 1147

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV------TPLQYPV 102
                  +   G   + F  + ++I  +      +         L  PV
Sbjct: 1148 NSG---QFILGQFSKPFNSIPDMIRHYSVNK--LPIRGAEHMCLLKPV 1190


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score = 83.8 bits (206), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 28/120 (23%), Positives = 47/120 (39%), Gaps = 15/120 (12%)

Query: 3   AVTVYHGKIS-----RETGEKLL----LATGL-DGSYLLRDSESVPGVYCLCVLYQGYIY 52
               +HGK+      R   E+LL    + TG  DGS+L+R+SE+  G Y L     G + 
Sbjct: 547 NEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQ 606

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQK---PDQGIVTPLQYPVEKSSGRG 109
             R+   +                F  + +LI+ +Q+           L  PV +++   
Sbjct: 607 HCRIHSRQDAGTP--KFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHE 664



 Score = 82.6 bits (203), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 25/105 (23%), Positives = 47/105 (44%), Gaps = 8/105 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   YH  ++R   E +L+    DG++L+R   + P  Y +    +G I   RV Q   
Sbjct: 664 ESKEWYHASLTRAQAEHMLMRVPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCRVQQEG- 721

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
                +T    +   F  + +LIS ++K        L+YP+ + +
Sbjct: 722 -----QTVMLGNSE-FDSLVDLISYYEKHPLYRKMKLRYPINEEA 760


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score = 83.4 bits (205), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 4/87 (4%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            +D    YHG ISR   EK+L   G +GS+L+R+SES    Y L +         R+ +  
Sbjct: 975  LDRQGWYHGSISRIDAEKILRPLG-EGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDP 1033

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAF 87
              S       G   R F  + ++I  F
Sbjct: 1034 DSSQYI---LGQFSRPFPTIPDMIRHF 1057


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score = 83.0 bits (204), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 13/105 (12%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           T +HG I R    +LL     DG +LLR+S +  G + L     G +  ++V  T+ G +
Sbjct: 469 TWFHGTIPRTESLRLLQQ---DGDFLLRESNNSLGDFVLSAKADGQVRHFKVQVTDNGMY 525

Query: 65  SAETAPGVHKRFFRKVKNLI-SAFQKPD---QGIVTPLQYPVEKS 105
             E         F  V NLI   +QK +   +     L  P+ K 
Sbjct: 526 RFEADQ------FPTVLNLISHHYQKREPVTKRTNCLLLNPICKD 564


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score = 83.0 bits (204), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 23/111 (20%), Positives = 44/111 (39%), Gaps = 11/111 (9%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG I+R   E +L+A    G +L+RDS +  G Y L V     +  Y ++  +   
Sbjct: 8   YSWYHGDITRPACESILMAQ-KPGLFLVRDSSTCKGGYVLSVSENNKVSHYIITN-KNSQ 65

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKP-DQGIVTPLQYPVEKSSGRGPQAP 113
           +          + F  +  ++  +++       T L     + +   P  P
Sbjct: 66  YQIGD------QTFNDLPEIVEFYKRHFLD--TTTLVESAPRVTEPTPVTP 108


>UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59F39_HUMAN
          Length = 376

 Score = 83.0 bits (204), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 15/102 (14%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYI-------YT 53
           ++    Y+  ISR+  EKLLL TG +G++++RDS +  G Y + V  +  +         
Sbjct: 279 LETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKH 337

Query: 54  YRVSQTETG--SWSAETAPGVHKRFFRKVKNLISAFQKPDQG 93
           Y + +T      +         K  F  +  LI+  Q    G
Sbjct: 338 YHIKETNDNPKRYYV-----AEKYVFDSIPLLINYHQHNGGG 374


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score = 82.6 bits (203), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 18/86 (20%), Positives = 40/86 (46%), Gaps = 7/86 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  +SR   E LL+   + G +++R S+S PG + + V ++  +  ++V +   G++ 
Sbjct: 32  WFHEGLSRHQAENLLMGKEV-GFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYF 90

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPD 91
             T        F  +  L+  ++   
Sbjct: 91  LWT------EKFPSLNKLVDYYRTNS 110


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score = 82.2 bits (202), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 25/105 (23%), Positives = 45/105 (42%), Gaps = 8/105 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   YH  +SR   E +L+    DG++L+R     P  + +    +G I   RV Q   
Sbjct: 743 ESKEWYHANLSRSQAENMLMRVPRDGAFLVRKRA-EPNSFAISFRAEGKIKHCRVQQ--E 799

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           G         +    F  + +LIS ++K        L+YP+ + +
Sbjct: 800 GQTVV-----LGTSEFDSLVDLISYYEKHPLYRKMKLRYPINEDT 839



 Score = 81.5 bits (200), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 28/120 (23%), Positives = 48/120 (40%), Gaps = 15/120 (12%)

Query: 3   AVTVYHGKIS-----RETGEKLL----LATGL-DGSYLLRDSESVPGVYCLCVLYQGYIY 52
               +HGK+      R+  E+LL    + TG  DGS+L+R+SE+  G Y L     G + 
Sbjct: 626 TEKWFHGKLGAGRDGRQIAERLLSEYCMETGAPDGSFLVRESETFVGDYTLSFWRSGRVQ 685

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQK---PDQGIVTPLQYPVEKSSGRG 109
             R+   +     +          F  +  LI+ +Q+           L  PV +++   
Sbjct: 686 HCRIHSRQEAG--SPKFYLTDNLVFDTLFALINHYQQVALRCNEFEMKLTEPVPQTNAHE 743


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score = 82.2 bits (202), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 29/106 (27%), Positives = 49/106 (46%), Gaps = 11/106 (10%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  T Y G I R   E++L  T  DG++L+R+S++  G Y   V+  G      V +T T
Sbjct: 618 DESTWYVGDIKRSQAEEMLRGT-CDGTFLIRESQTQKGSYACSVVVDGDTKHCVVYKTVT 676

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPV 102
           G   AE         +  +K+L+  ++     + +  +   L +PV
Sbjct: 677 GYGFAE-----PYNLYSSLKDLVLHYKNVSLVQHNDHLNVTLAHPV 717



 Score = 73.4 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 13/110 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRD-SESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++    Y G+ISRE   + L  T  DG++L+RD S  + G Y L +   G     ++   
Sbjct: 357 LNDAEWYWGEISREEVNEKLRDTP-DGTFLVRDASSKLEGEYTLTLRKGGNNKLIKIY-H 414

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEK 104
             G +            F  V  LI+ ++       +  + T L YPV K
Sbjct: 415 REGRYGFS-----EPLTFLSVVELINHYRHESLAQYNAKLDTKLLYPVSK 459


>UniRef50_UPI000180D0F7 PREDICTED: similar to dual adaptor of phosphotyrosine and
           3-phosphoinositides n=1 Tax=Ciona intestinalis
           RepID=UPI000180D0F7
          Length = 254

 Score = 82.2 bits (202), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 30/125 (24%), Positives = 48/125 (38%), Gaps = 23/125 (18%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  YHG I+R   E LL+A G +GS+L+RD   V G  C+ V     +  +++  T 
Sbjct: 5   VEDLEWYHGGITRHVAEALLMANGREGSFLMRD---VTGGQCISVRTNDAVKHFKIEVTA 61

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP--------------DQGIVTPLQYPVEKSS 106
                           F  + +L+  F                 D G +  L+YP  KS 
Sbjct: 62  DAEVVFAHGS------FMSMAHLLQVFANQLILCADLGSLSKNFDHGTMLILKYPYPKSV 115

Query: 107 GRGPQ 111
                
Sbjct: 116 DEPDD 120


>UniRef50_A8Q2Q3 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q2Q3_BRUMA
          Length = 483

 Score = 81.5 bits (200), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 26/113 (23%), Positives = 45/113 (39%), Gaps = 18/113 (15%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           ++    +H ++SR    +L+L  G+DG   +L+R SE+ PG + L    QG     R+  
Sbjct: 323 LEIYPWFHARLSRSVSARLVLHNGVDGHGLFLVRQSETRPGEFVLTFNCQGKAKHVRIVM 382

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
              G          H+  F  + +L+  F+            P+   S   P 
Sbjct: 383 MPDGECRI------HQMIFETMVDLLEYFRDN----------PIPLESSSTPP 419


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score = 81.5 bits (200), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 25/118 (21%), Positives = 48/118 (40%), Gaps = 17/118 (14%)

Query: 3   AVTVYHGKI--SRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS- 57
           +   +HGK+   R   E LL       DG++L+R+S++  G + L    +  +   R+  
Sbjct: 557 SEKWFHGKLEGGRRKAEDLLKEYSYLGDGTFLVRESDTFVGDFSLSFWRKDSVNHCRIRS 616

Query: 58  ---QTETGSWSAETAPGVHKRFFRKVKNLISAFQK---PDQGIVTPLQYPVEKSSGRG 109
              + +T  +  +         F  + +LI+ +QK     Q     L+ PV +     
Sbjct: 617 KQERGQTKYYLIDNLA------FDSLYSLITHYQKYPLRSQDFQQILKEPVPQPQSHH 668



 Score = 74.9 bits (183), Expect = 7e-13,   Method: Composition-based stats.
 Identities = 21/101 (20%), Positives = 40/101 (39%), Gaps = 7/101 (6%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             YH K+ R   E +L     DG++L+R +      Y +    +G I    + Q     +
Sbjct: 671 PWYHEKLDRTRAEDMLKRIPSDGAFLVRQNGVDTNSYAISFRAEGKIKHCIIKQEGR-LF 729

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           +   A       F  +  L++ ++K        L++PV + 
Sbjct: 730 TIGNAQ------FESLVELVNYYEKKPLYRKMKLKHPVNEK 764


>UniRef50_A9USN6 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9USN6_MONBE
          Length = 954

 Score = 81.5 bits (200), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 5/94 (5%)

Query: 6  VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
               ISR+  E  L     DG+YL+R S S PG Y LCV+  G I  ++V         
Sbjct: 10 WLSRHISRQDAETALKGHP-DGTYLIRASVSAPGDYVLCVVCHGQIQHHQVCIKHNNGRM 68

Query: 66 AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
             +     R  + +  L+  ++    G+   L+
Sbjct: 69 LTRSG----RELQNLSELLRHYKTTLDGLEVLLR 98


>UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SVT4_TETNG
          Length = 1377

 Score = 81.5 bits (200), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 29/123 (23%), Positives = 51/123 (41%), Gaps = 12/123 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   YH  ++R   E +L+    DG++L+R   S    Y +    +G I   R+ Q   
Sbjct: 683 ESREWYHSSLTRVQAEHMLMRVPRDGAFLVRK-RSEHNSYAISFRAEGKIKHCRIQQEGR 741

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV-----EKSSGRGPQAPTGR 116
                 +A       F  + +L+S ++K        L+YP+     +K      +AP  R
Sbjct: 742 LFMLGSSAE------FESLMDLVSYYEKHPLYRKMKLRYPINEDTLDKMGTTVSRAPPER 795

Query: 117 RDS 119
           R S
Sbjct: 796 RRS 798



 Score = 81.5 bits (200), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 16/120 (13%)

Query: 3   AVTVYHGKIS-----RETGEKLLLA----TGLDGSYLLRDSESVPGVYCLCVLYQGYIYT 53
           A   +HGK+      R+  EKLL         DG++L+R+SE+  G Y L     G +  
Sbjct: 567 AERWFHGKLGGGRDGRQVAEKLLQEYCEGGAKDGTFLVRESETFVGDYTLSFWRSGRVQH 626

Query: 54  YRV-SQTETGSWSAETAPGVHKRFFRKVKNLISAFQ---KPDQGIVTPLQYPVEKSSGRG 109
            R+ S+ E+GS        +    F  +  LI  ++            L  PV + +   
Sbjct: 627 CRIHSRQESGSTRFYLTDNL---VFDSLYRLICHYRDTPLRCNEFEMRLGNPVPQPNAHE 683


>UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY34_ACYPI
          Length = 214

 Score = 81.5 bits (200), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 23/104 (22%), Positives = 40/104 (38%), Gaps = 10/104 (9%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +   YH  +SR+    +L A G  DG +L+R+S+S  G Y L     G I    +     
Sbjct: 103 SQPWYHKNMSRDQAANVLHALGNKDGVFLIRESKSKCGSYVLSFKCGGKIIHTPIVTQMD 162

Query: 62  GS-----WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY 100
                  ++ +         F  +  L+  +Q     + T L +
Sbjct: 163 PLNDQVCFTLDNGVI----KFYDLLQLVEFYQLNAGSLPTRLMH 202


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score = 81.5 bits (200), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 24/113 (21%), Positives = 41/113 (36%), Gaps = 16/113 (14%)

Query: 5   TVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY------IYTYRVS 57
             Y   I R   + KLLL     G+YL+R S S    Y L V +         +  YR+ 
Sbjct: 180 AWY--NIGRREADRKLLLVGNPQGTYLIRPS-SETQNYALSVRHYDSEKNMWVVKHYRIR 236

Query: 58  -QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
                G +         +  F  +++L++ +     G+   L  P  ++    
Sbjct: 237 ILDNNGGFFISI-----RTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPP 284


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score = 81.1 bits (199), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 42/115 (36%), Gaps = 16/115 (13%)

Query: 5   TVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY------IYTYRVS 57
             Y   I R   + KLLL     G+YL+R S S    Y L V +         +  YR+ 
Sbjct: 96  AWY--NIGRREADRKLLLVGNPKGTYLIRPS-SETQNYALSVRHYDSEKNMWVVKHYRIR 152

Query: 58  -QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
                G +         +  F  +++L++ +     G+   L  P  ++     Q
Sbjct: 153 ILDNNGGFFISI-----RTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPPVQ 202


>UniRef50_UPI000192628F PREDICTED: similar to chimerin (chimaerin) 1, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI000192628F
          Length = 444

 Score = 81.1 bits (199), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 13/90 (14%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG ISRE  EKL++    +G YL R+SE +PG Y L   +      YR+          
Sbjct: 81  FHGAISREEAEKLVMKD--EGCYLTRESERLPGTYALTFRFNNAPKNYRLYYDTD----- 133

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
           E    V ++ F  + +L+        G++T
Sbjct: 134 EKMHFVGEKQFETIHDLV------ADGLIT 157


>UniRef50_UPI0001760433 PREDICTED: similar to beta chimerin n=1 Tax=Danio rerio
           RepID=UPI0001760433
          Length = 594

 Score = 81.1 bits (199), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 16/90 (17%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG ISRE  ++LL   G +G+YL+R+S+  PG Y L + + G    YR+          
Sbjct: 73  FHGLISREQADELL--AGTEGAYLIRESQRQPGTYTLALRFGGQTLNYRLFYDGKHF--- 127

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
                V ++ F  V +L+        G++T
Sbjct: 128 -----VGEKRFESVHDLV------TDGLIT 146


>UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B0B45
          Length = 287

 Score = 81.1 bits (199), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 11/95 (11%)

Query: 5   TVYHG----KISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
            VYHG     + R+  E+LL   G   GS+++R+S    G Y L V Y+  +  YR+ + 
Sbjct: 117 KVYHGWLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVKYR-SVKHYRIYRL 175

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI 94
           +   +            F+ ++++I+ +     G+
Sbjct: 176 DNSWYYIS-----PSLTFQCLEDMINHYCDFADGL 205


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score = 80.7 bits (198), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 25/87 (28%), Positives = 38/87 (43%), Gaps = 4/87 (4%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D    YHG ISR   EK+L     +GS+L+R+SES    Y L +         R+ +  
Sbjct: 731 LDRQGWYHGSISRIDAEKILRPL-SEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDA 789

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAF 87
                 +   G   R F  + ++I  F
Sbjct: 790 DSG---QFILGQFSRPFPTIPDMIRHF 813


>UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi sarcoma viral oncogene
           homolog 1 n=1 Tax=Ciona intestinalis RepID=UPI000180BC98
          Length = 432

 Score = 80.7 bits (198), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 29/111 (26%), Positives = 46/111 (41%), Gaps = 13/111 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQG-----YIYTY 54
           +++   Y G ISRE  E  LL  G  DG++L+R      G Y + +L         +Y Y
Sbjct: 20  IESEPCYFGTISREEAETNLLERGENDGTFLVRK--GTDGEYRISLLSSTSDGSCRVYNY 77

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           RV      ++S +         F  V  L+  + +   G+ + L  P  K 
Sbjct: 78  RVKLATNRTYSIDD-----TYSFPAVHQLVRYYSQKCSGLPSKLVAPCPKE 123


>UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7QIL2_IXOSC
          Length = 372

 Score = 80.7 bits (198), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 21/89 (23%), Positives = 40/89 (44%), Gaps = 7/89 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + A   Y G I R   +++L     DG +L+RDSE+  G   + +        +RV   E
Sbjct: 270 LRAKEWYFGSIPRSQCDQVLNECAQDGDFLIRDSETNVGDLSVSLKAPLRNKHFRV-HVE 328

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK 89
            G +         +R F ++ +L+  +++
Sbjct: 329 DGVFCI------GQRRFSQLDDLVEHYKR 351


>UniRef50_Q1LWW1 Novel protein similar to vertebrate phospholipase C, gamma 2
           (Phosphatidylinositol-specific) (PLCG2) (Fragment) n=2
           Tax=Danio rerio RepID=Q1LWW1_DANRE
          Length = 270

 Score = 80.7 bits (198), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 25/96 (26%), Positives = 42/96 (43%), Gaps = 9/96 (9%)

Query: 3   AVTVYHGKI--SRETGEKLLLA--TGLDG---SYLLRDSESVPGVYCLCVLYQGYIYTYR 55
           +   +HG++   R T EKLL     G DG   ++L+R+S +  G YC+ +  +G I  YR
Sbjct: 51  SEPWFHGRLAEGRITAEKLLRDYCKGTDGNDETFLVRESNTFIGNYCISLWTRGRIQHYR 110

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
           +                 K  F  +  LI  +++  
Sbjct: 111 IFCFPENGHKI--FFLKSKECFPSMCALIDYYRQQS 144



 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 22/102 (21%), Positives = 46/102 (45%), Gaps = 7/102 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  ++  +SR   E  LL    DG++L+R   +    + L +  +G I  Y++ +  
Sbjct: 166 LHHMGWFYSNMSRAEAEDCLLRIPRDGAFLIRK-RNERDTFALSIRSEGDIKHYKIFRKS 224

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           +    A+         F  +++++S F+       T L+YPV
Sbjct: 225 SKYVLADAYE------FFSLEDMVSCFRNQQFAGKTKLRYPV 260


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score = 80.7 bits (198), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 27/120 (22%), Positives = 44/120 (36%), Gaps = 13/120 (10%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL-YQGYIYTYRVSQTET 61
               +H  +S    E+LLLA G  G+YL+R+S S PG + + V      +    +     
Sbjct: 137 TERWFHAGLSGPEAERLLLAEGKHGTYLVRESHSSPGQFAISVKAADDKVIHVMIYSKSD 196

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQK----PDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
                +   G     F  +  L+  + +       G V  L+  +   S R P      R
Sbjct: 197 KF---DIGGGA---TFSTISELLEHYTRNPMVDQAGTVVNLKQLLP--STRVPATSIDIR 248



 Score = 74.5 bits (182), Expect = 9e-13,   Method: Composition-based stats.
 Identities = 28/132 (21%), Positives = 45/132 (34%), Gaps = 16/132 (12%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + ++  IS    E+LL   G +GS+L R S S P  Y L V     I   ++        
Sbjct: 23  SNFYYPISGVDAERLLNTCGTEGSFLARPSGSSPSNYTLSVHRGDRIKHVKIQNNGDC-- 80

Query: 65  SAETAPGVHKRFFRKVKNLISAF------QKPDQG----IVTPLQYPVEKSSGRGPQAPT 114
                       F  +  L+  +       +   G    +  PL  P  ++ G     P+
Sbjct: 81  ----LDLYGGETFASLSELVQFYVENPGQLRERDGEIIVLKCPLVIPPTEAVGWAFSRPS 136

Query: 115 GRRDSDICLNAP 126
             R     L+ P
Sbjct: 137 TERWFHAGLSGP 148


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score = 80.3 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 20/87 (22%), Positives = 35/87 (40%), Gaps = 4/87 (4%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    +HG I+R   E +L     +GS+L+R+SES    Y L +         R+ +  
Sbjct: 792 LEKQGWFHGAITRVEAENVLRML-REGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDG 850

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAF 87
                     G   + F  +  +I  F
Sbjct: 851 NDECYI---LGQFSKPFHSIPEMIRHF 874


>UniRef50_B7Q2R0 Adaptor protein Crk, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q2R0_IXOSC
          Length = 310

 Score = 80.3 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 6/100 (6%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + + G +SR+    +L+A    G +L+R+S ++ G   LCV  +  +  Y +++      
Sbjct: 12  SWFFGPMSRQEATDMLMAEHEAGIFLVRNSATISGDLVLCVREENKVSHYIINRVSQDE- 70

Query: 65  SAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVE 103
             +T   +  + F  + +L++ ++        TPL  PV 
Sbjct: 71  --QTRFRIGDQMFPDIPSLLNFYKLHYLD--TTPLVKPVP 106


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score = 80.3 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 10/95 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHG++SR   E++L A   DG +L+RDS + PG Y L  ++ G      +    
Sbjct: 482 LRQEPWYHGRMSRRAAERMLRA---DGDFLVRDSVTNPGQYVLTGMHAGQPKHL-LLVDP 537

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV 95
            G              F  + +LI    +  Q IV
Sbjct: 538 EGVVR------TKDVLFESISHLIDHHLQNGQPIV 566


>UniRef50_UPI0000E460CB PREDICTED: similar to V-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E460CB
          Length = 305

 Score = 80.3 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 22/113 (19%), Positives = 45/113 (39%), Gaps = 11/113 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    + G I+R   + LL+     G++L+RDS + PG   LCV     +  Y +++   
Sbjct: 14  NKHLWHFGGITRSETDNLLIQK-RPGTFLVRDSRTCPGDSVLCVSENSKVSHYIITRKAD 72

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVEKSSGRGPQAP 113
                +       + F  + ++++ ++        T L  P  K+    P   
Sbjct: 73  QFVIGD-------QIFSTLPDILNFYRGHYLD--TTVLVEPCPKNRMVQPPPQ 116


>UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SW52_TETNG
          Length = 338

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 22/104 (21%), Positives = 36/104 (34%), Gaps = 10/104 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D    Y G + R   +  L      G +L+RDS + PG Y L V     +  Y ++    
Sbjct: 10  DRSAWYFGPVLRPEAQNRLQGQ-KHGMFLVRDSSTCPGDYVLSVSENSKVSHYIITSLPN 68

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVEK 104
             +          R F  +  L+  ++        T L  P  +
Sbjct: 69  KRFKIGD------REFEHLPALLEFYKYHYLD--TTTLIEPAPR 104


>UniRef50_A8PJS1 RhoGAP domain containing protein n=5 Tax=Chromadorea
           RepID=A8PJS1_BRUMA
          Length = 407

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 15/91 (16%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG I RE  + +LL  G +G++L+R S   PG   LC+ + G +  Y++          
Sbjct: 42  FHGLIEREVADNMLLEAG-EGAFLVRASRRSPGANTLCMFFDGRVLNYKLFYDGMHY--- 97

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTP 97
                V ++ F  +++L+        G++T 
Sbjct: 98  -----VGEKRFEHLEDLV------ADGLITM 117


>UniRef50_UPI0001925DBD PREDICTED: similar to Dual adaptor of phosphotyrosine and
           3-phosphoinositides n=2 Tax=Hydra magnipapillata
           RepID=UPI0001925DBD
          Length = 258

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 29/129 (22%), Positives = 52/129 (40%), Gaps = 19/129 (14%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HG ISR T E +L++   +G+YLLR   S    Y + V  Q  +  Y ++  +
Sbjct: 18  LADLDWFHGDISRSTAETILISNANEGTYLLRI-NSDKQNYSVSVRCQNSVKHYVINHDK 76

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP---QAPTGRR 117
             +             F  +K L+  F+           +PV  S+       Q P   +
Sbjct: 77  KKNIFV-----FGIATFYSLKELLDHFE----------SHPVLSSAEDETVVLQKPYKNK 121

Query: 118 DSDICLNAP 126
           D+++    P
Sbjct: 122 DNELHSYTP 130


>UniRef50_Q4SKC0 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4SKC0_TETNG
          Length = 1249

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 22/100 (22%), Positives = 39/100 (39%), Gaps = 6/100 (6%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               ++  +SR   E  L+    DG++L+R  E  P  + +     G +   R+ +  T 
Sbjct: 629 NEGWFYSDLSRGQAEDYLMRIPRDGAFLIRQREGEPDSFAITFKGDGKVKHCRIQKEGTR 688

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
                T       +F  +  L+S F+         L+YPV
Sbjct: 689 YLLGTT------TYFESLVELVSYFRNRPLYRKIKLRYPV 722



 Score = 73.8 bits (180), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 23/97 (23%), Positives = 39/97 (40%), Gaps = 13/97 (13%)

Query: 3   AVTVYHGKIS--RETGEKLLLA-----TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYR 55
               +HG +   R+  E+L+        G DG++L+R S+ V   Y L     G +   R
Sbjct: 514 TEPWFHGHMKDGRQMAERLIYEYCAETGGQDGTFLVRPSDRVVLSYTLSFWRNGRVQHCR 573

Query: 56  VSQTETGS--WSAETAPGVHKRFFRKVKNLISAFQKP 90
           V     G   +   TA       F  + +LI  +++ 
Sbjct: 574 VRVGNQGGRPYYFLTAN----LHFPSLISLIQHYREN 606


>UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SCW1_NEMVE
          Length = 275

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 31/128 (24%), Positives = 52/128 (40%), Gaps = 15/128 (11%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D +  YHG + R   E +L      G +L+RDS ++PG Y L V   G +  Y ++   T
Sbjct: 5   DQLPWYHGVLKRVETEGILNGKPP-GVWLVRDSTTIPGDYVLSVSESGKVSHYIINNKGT 63

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKP-DQGIVTPLQYPVEKS----SGRGPQAPTGR 116
                +       + F  + ++I  ++K       T L+  V  S      +   A  G+
Sbjct: 64  MYTIGD-------QTFPDLPSIIEFYKKHFLD--TTTLKEHVPNSECNIKVKALYAFPGK 114

Query: 117 RDSDICLN 124
            D D+   
Sbjct: 115 DDEDLPFK 122


>UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein activator 1 n=1 Tax=Ciona
           intestinalis RepID=UPI000052352E
          Length = 936

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 12/113 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY-IYTYRVSQTETGSW 64
            YHGK+ R   E+ LL   + G YL+R+S+  PG Y L  L +   +  +R+       +
Sbjct: 58  WYHGKLDRRIAEERLLEVNVAGGYLVRESQKKPGSYVLSFLSENIGMTHFRIISVCGDFY 117

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
                  +  R F  ++ LI+ +          L+  V ++  + P+    RR
Sbjct: 118 -------IGGRQFECLEQLIAYYTHRS----CLLEGEVLRTPIQPPEPVDDRR 159



 Score = 76.8 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 24/117 (20%), Positives = 46/117 (39%), Gaps = 6/117 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +H  I++E    LL A    GS+L+R S+S PG Y L      YI  +++ +   
Sbjct: 225 EGKEWFHAGITKEEAYSLLSAVDRSGSFLIRVSDSTPGDYVLYFFTGQYIQRFKLHRVGQ 284

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
             +       +  R +  +  ++  ++         L Y V KS+    +      +
Sbjct: 285 NRFE------MGGRCYGSIDEVVEHYRHEQIVEGHTLTYAVPKSTDISRECKVDIYE 335


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 12/95 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHG++SR   EKLL A   DG +L+RDS + PG Y L  ++ G      +    
Sbjct: 473 LRQEPWYHGRMSRRAAEKLLRA---DGDFLVRDSVTNPGQYVLTGMHAGQPKHL-LLVDP 528

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV 95
            G              F  + +LI    K   G+ 
Sbjct: 529 EGVVR------TKDVLFESISHLIDYHLK--NGLP 555


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score = 79.5 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 29/106 (27%), Positives = 48/106 (45%), Gaps = 12/106 (11%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +  T Y GKI+R   E++L     DG++L+R+S S  G Y   V+  G      + +T T
Sbjct: 618 EERTWYVGKINRTQAEEMLSGK-RDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTAT 675

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPV 102
           G   AE         +  +K L+  +Q     + +  +   L +PV
Sbjct: 676 GFGFAE-----PYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPV 716



 Score = 71.8 bits (175), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 30/110 (27%), Positives = 45/110 (40%), Gaps = 13/110 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRD-SESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     Y G ISRE   + L  T  DG++L+RD S  + G Y L +   G     +V   
Sbjct: 325 LQDAEWYWGDISREEVNEKLRDTP-DGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVF-H 382

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEK 104
             G +            F  V +LI+ ++       +  + T L YPV K
Sbjct: 383 RDGHYGFS-----EPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427


>UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194BDF4
          Length = 1106

 Score = 79.1 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 26/120 (21%), Positives = 44/120 (36%), Gaps = 15/120 (12%)

Query: 3   AVTVYHGKIS-----RETGEKLLLA-----TGLDGSYLLRDSESVPGVYCLCVLYQGYIY 52
               +HGK+      R+  EKLL        G DG++L+R+SE+  G Y L       + 
Sbjct: 384 TEKWFHGKLGGGRDGRQIAEKLLHEYCTETGGKDGTFLVRESETFVGDYTLSFWRSSRVQ 443

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQK---PDQGIVTPLQYPVEKSSGRG 109
             R+   +     A          F  + +LI  +++           L  PV + +   
Sbjct: 444 HCRIHSRQEAG--ATKFYLTDNLVFDSLYSLICHYREVPLRCNEFEMRLTDPVPQPNAHE 501



 Score = 55.6 bits (133), Expect = 5e-07,   Method: Composition-based stats.
 Identities = 15/65 (23%), Positives = 30/65 (46%), Gaps = 3/65 (4%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY--QGYIYTYRVSQT 59
           ++   YH  ++R   E +L+    DG++L+R   S P  Y +         +Y Y+  + 
Sbjct: 501 ESKEWYHASLTRLQAEHMLMRVPRDGAFLVRK-RSEPNSYAISFRKCTVKALYDYKAQRE 559

Query: 60  ETGSW 64
           +  S+
Sbjct: 560 DELSF 564


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score = 79.1 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 44/113 (38%), Gaps = 13/113 (11%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLC-VLYQGYIYTYRVSQTETGSW 64
            YHGK+ R   E+ L      GSYL+R+S+  PG + L  +     +  +R+       +
Sbjct: 185 WYHGKLDRTIAEERLRQARNPGSYLIRESDRRPGSFVLSFLSMTNVVNHFRIIAMCGDYY 244

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
                  +  R F  + +LI  +       V+ L    +  S   P  P   R
Sbjct: 245 -------IGGRRFSSLSDLIGYYSY-----VSCLLKGEKLLSPVAPPEPVEDR 285



 Score = 69.5 bits (169), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 3/87 (3%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    YHG I+++    LL+  G   S+L+R S++ PG Y L       I  +++S T  
Sbjct: 355 EGKVWYHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRTNDIIQRFKISPTSN 414

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ 88
             +      G +   +  +  L   FQ
Sbjct: 415 NQYM---MGGRYYNRYEPICMLGHHFQ 438


>UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homininae RepID=Q9H6Q3-2
          Length = 210

 Score = 79.1 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 22/92 (23%), Positives = 39/92 (42%), Gaps = 11/92 (11%)

Query: 3   AVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQ-----GYIYTYRV 56
           +    +  +SRE  E+LLL  G   G++L+R+S++  G Y L V          I  YR+
Sbjct: 91  SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQ 88
              + G           +  F  ++ L+  + 
Sbjct: 151 HCLDNGWLYIS-----PRLTFPSLQALVDHYS 177


>UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q3U8_BRUMA
          Length = 1284

 Score = 79.1 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 39/111 (35%), Gaps = 13/111 (11%)

Query: 3   AVTVYHGKISRETGEKLLLATG--LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
               +HGK  R+T    LL      +G +L+RDS    G Y L  L+   ++  R+    
Sbjct: 564 TEEWFHGKTDRDTARIRLLEHKDKGNGLFLVRDSTIFIGDYSLSFLHNEKVHHCRIRTRM 623

Query: 59  -TETGSWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKS 105
                 +       +  +    +  LIS + K         T L  P  + 
Sbjct: 624 VNGEKKYYF-----LENKQMDTLYELISHYTKERLRTPNFSTTLITPCPQP 669



 Score = 76.1 bits (186), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 24/101 (23%), Positives = 43/101 (42%), Gaps = 11/101 (10%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  +  K  R   E+LL     DG++LLR S +   V+ L +   G I+ Y + +     
Sbjct: 675 MIWFCEKTDRNRAEELLNTVQQDGAFLLRFSSTDKNVFVLSLRVDGEIWHYHLKRDGRIF 734

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPD--QGIVTPLQYPV 102
              +T        F  +  ++  +   +  +GI   L+YPV
Sbjct: 735 VVNQT-------IFENLNQIVEYYSTREFVRGIC--LKYPV 766


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score = 78.8 bits (193), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 45/113 (39%), Gaps = 15/113 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +   +HG ++R+  E+LL     DG +L+R+S +  G + L  +  G      +    
Sbjct: 395 LQSKPWFHGHVTRKEAEQLLSH---DGDFLVRESTTTKGQFVLSGVQDGQYKHL-LLVDP 450

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGR 108
            G            R F  V +LIS  +         G V  L+ PV +   R
Sbjct: 451 NGVVR------TKDRQFDSVSHLISFHRDNTLPIVSSGSVLLLRQPVTRQIER 497


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score = 78.8 bits (193), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 9/108 (8%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ--TE 60
           +   +HG ISRE  EKL+     +G +L+RDS S PG + L V ++G    + V++   +
Sbjct: 123 SHAWFHGGISREKAEKLIRE---NGDFLVRDSISKPGNFVLTVRWKGVSMHFVVNKVVLK 179

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAF----QKPDQGIVTPLQYPVEK 104
             S  A       K  F  + +LI  +    +   Q     +Q+PV +
Sbjct: 180 AHSPYASVQYQFEKECFDAIPSLIKFYVGNCRPVSQASGAVIQHPVNR 227


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score = 78.4 bits (192), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 31/110 (28%), Positives = 42/110 (38%), Gaps = 15/110 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     +HGK+SR   E LL    L+G +L+R+S + PG Y L  L  G      +    
Sbjct: 342 LRGEPWFHGKLSRREAEALLQ---LNGDFLVRESTTTPGQYVLTGLQSGQPKHL-LLVDP 397

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKS 105
            G              F  V +LIS            G    LQ PVE+ 
Sbjct: 398 EGVVR------TKDHRFESVSHLISYHVDNHLPIISAGSELCLQQPVERK 441


>UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9Y7_MONBE
          Length = 947

 Score = 78.0 bits (191), Expect = 9e-14,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 41/109 (37%), Gaps = 5/109 (4%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
              +HG I+R   E LL    + G +L R SE+  G Y L V  +     + + +T    
Sbjct: 837 HDWFHGVITRREAEDLLAPKPI-GCFLTRISETRLG-YTLSVRTRHACKHFVIEETRES- 893

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVEKSSGRGPQ 111
             +         +F  ++ LI  ++  P       L  P  +  GR   
Sbjct: 894 -PSRYMLQGRDVYFDTLERLIEHYRGHPANDQGDHLTVPCGQPLGRPAD 941


>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score = 78.0 bits (191), Expect = 9e-14,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 43/106 (40%), Gaps = 9/106 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E LL     + SYL+R+SE+    + L +         ++S+T+
Sbjct: 375 LENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 433

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
              +      G +   F  V  ++  +      I       L YPV
Sbjct: 434 NNKYVL----GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 475


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score = 78.0 bits (191), Expect = 9e-14,   Method: Composition-based stats.
 Identities = 29/117 (24%), Positives = 46/117 (39%), Gaps = 17/117 (14%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + +HG ISR+  E LL + G  G +L+R SE + G Y L    +     + +  TE    
Sbjct: 324 SWFHGIISRQEAEDLL-SEGEPGHFLVRVSERILG-YVLSYRCKDEFKHFLIDATEGCY- 380

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDI 121
                   H+  F  +  L+   +            P+  S G     P G+R S +
Sbjct: 381 ----MLLGHQIRFTSLAELVEFHK----------GEPITMSGGEQLLQPCGQRPSGV 423


>UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZG2_MONBE
          Length = 1021

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 24/87 (27%), Positives = 36/87 (41%), Gaps = 6/87 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  +HG ISR   E+LL    + G +L+R SE+  G Y L          Y V Q   G 
Sbjct: 825 MPWFHGLISRREAEELLRPRYI-GCFLVRVSENRFG-YTLSYRVSDRCRHYMVEQNTQGQ 882

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKP 90
           ++      +       +  LI  FQ+ 
Sbjct: 883 YALVGVSKIA----DSLNELIEWFQRN 905


>UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T185_NEMVE
          Length = 983

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 21/117 (17%), Positives = 49/117 (41%), Gaps = 14/117 (11%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           + GK+ R   E+  +    DG++L+R+S +  G Y L V ++      ++   E G++  
Sbjct: 661 FAGKMDRTEAEQETMGR-SDGTFLVRESANRAGEYALSVRFRNATKHIKI-PYEDGTFCL 718

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKSSGRGPQAPTGRRD 118
                   + F  +  L++ +++        G+ T L+     +  +  +    R +
Sbjct: 719 -----TQSKVFDSIPELVAYYRENTLGVSFTGLDTTLR--CGLNEDQDNREVGWRTE 768


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 42/112 (37%), Gaps = 15/112 (13%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           +   YHGK+SR+  E LL+    DG +L+R+S + PG Y L  L  G      +     G
Sbjct: 523 SEECYHGKLSRKAAESLLVK---DGDFLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEG 578

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGRG 109
                         F  V +LI             G    L+ PV K +   
Sbjct: 579 KVR------TKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPA 624


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 16/91 (17%), Positives = 37/91 (40%), Gaps = 7/91 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     +    SR   E+LL   G+ G +++R  +S PG + + V ++  +  ++V +  
Sbjct: 53  IQTPRWFQENASRSAAEELLRHKGV-GEFVIRGCQSSPGEFSISVRHESDVQHFKVMRDS 111

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
            G +            F  +  L+  ++   
Sbjct: 112 RGQYFL------WSEKFTSLNKLVDFYRTSS 136


>UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00004D6B5A
          Length = 321

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 8/90 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           + +   +HG ISR    +L+ + G++G   +L+R SE+  G Y L   +QG     R++ 
Sbjct: 218 LASSPWFHGPISRVKAAQLVQSQGVEGHGVFLVRQSETRRGEYVLTFNFQGRAKHLRLTL 277

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQ 88
           TE G    +         FR V  ++  F+
Sbjct: 278 TERGQCHVQHL------RFRSVLEMLQYFR 301


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 5/87 (5%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    YHG I+R   E  L     +GS+L+R+ ES    Y L +         R+ + E
Sbjct: 1405 LERQGWYHGAITRIEAETTLRPL-SEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNE 1463

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAF 87
            TG +      G   R F  V  +I  F
Sbjct: 1464 TGQYIL----GQFSRPFETVPEMIRHF 1486


>UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001927133
          Length = 521

 Score = 77.6 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 30/115 (26%), Positives = 44/115 (38%), Gaps = 12/115 (10%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           + +  +HG ISR   EK+L      GS+L+R SE V G Y +          + +  +  
Sbjct: 406 NPLLWFHGIISRHEAEKILEKKDK-GSFLVRVSERVWG-YTVSFKDIARCKHFLIDTSAN 463

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTP-LQYPVEKSSGRGPQAPT 114
           G     T   VH      +  LI   +  P  G+    L YP     G+    P 
Sbjct: 464 GYQFFGTEQIVH----NSLNELIDYHKINPISGLGQEILIYPC----GQETNPPD 510


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score = 77.2 bits (189), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 42/112 (37%), Gaps = 15/112 (13%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           +   YHGK+SR+  E LL+    DG +L+R+S + PG Y L  L  G      +     G
Sbjct: 280 SEECYHGKLSRKAAESLLVK---DGDFLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEG 335

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGRG 109
                         F  V +LI             G    L+ PV K +   
Sbjct: 336 KVR------TKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPA 381


>UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=1 Tax=Ciona intestinalis
           RepID=UPI0000523E1B
          Length = 322

 Score = 77.2 bits (189), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 22/104 (21%), Positives = 44/104 (42%), Gaps = 9/104 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     Y G + R   E++L  T  +G++L+R+S+S+ G + L V  +  +  Y + +  
Sbjct: 9   MQQQIWYFGSLERIVAEQILQPT-SEGTFLVRNSKSILGDFVLSVKQKEEVIHYIIRREH 67

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           +          +    F  +  L+  ++    G    L  P+ K
Sbjct: 68  SKLV-------LKNHVFLSMVTLLEHYKTHFVGEG-RLIKPMNK 103


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score = 77.2 bits (189), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 22/98 (22%), Positives = 36/98 (36%), Gaps = 14/98 (14%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD--------GSYLLRDSESVPGVYCLCVLYQGYIY 52
           +     Y  + SR   E  LL T  D        G+++LR SE+ PG + + V     + 
Sbjct: 55  LYPHPWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVKEGSSVL 114

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKP 90
            +R+     G +   T        F  +  LI   +  
Sbjct: 115 HFRIFFDPKGKYYIWT------NKFDSINALIDYHRHQ 146


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score = 77.2 bits (189), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 8/92 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD--GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +     +HG ISR    +L+   G D  G +L+R SE+  G Y L   +QG     R+S 
Sbjct: 366 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 425

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKP 90
           TE G    +         F  V +++  FQ+ 
Sbjct: 426 TERGQCRVQHL------HFPSVVDMLHHFQRS 451


>UniRef50_B3XVX1 Protein tyrosine kinase syk (Fragment) n=1 Tax=Monosiga ovata
           RepID=B3XVX1_9EUKA
          Length = 835

 Score = 77.2 bits (189), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 21/102 (20%), Positives = 44/102 (43%), Gaps = 15/102 (14%)

Query: 8   HGKISRETGEKLLLA-TGLDGSYLLRDSE------SVPGV---YCLCVLYQGYIYTYRVS 57
           +G + R+  E LL   +  DGSYL+R ++        PG    + + VL++G      + 
Sbjct: 113 YGLLGRDAAEALLQRLSPKDGSYLVRQTDKPTPDDRFPGAMAHFVVSVLHKGRGQHLLIR 172

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
           +  +G +  +         +R +  L+  ++    G+   L+
Sbjct: 173 KFPSGKYGIDDGL-----RYRTLAELVDHYRHGRDGLCCELR 209


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score = 76.8 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 25/113 (22%), Positives = 40/113 (35%), Gaps = 13/113 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E  L      G YL+R+SES    Y + +          V+QT+
Sbjct: 390 LEKQPWYHGAISRAEAESRLQPCKEAG-YLVRNSESGNSRYSIALKTSQGCVHIIVAQTK 448

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV------TPLQYPVEKSSG 107
              ++      V    F  +  ++  +      +         L YPV     
Sbjct: 449 DNKYTLNQTSAV----FDSIPEVVHYYSNEK--LPFKGAEHMTLLYPVHSKLH 495


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score = 76.8 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 27/108 (25%), Positives = 45/108 (41%), Gaps = 13/108 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   YHG ISR   E LL     + SYL+R+SE+    + L +         ++S+T+
Sbjct: 353 LESQFWYHGAISRADAESLLRLC-KEASYLVRNSETNKIDFSLSLKSIQGFMHMKLSRTK 411

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV------TPLQYPV 102
              +      G +   F  V  +I  +    Q +         L YPV
Sbjct: 412 ENKYVL----GHNSPPFNSVPEIIHHYA--SQKLPIKGAEHMSLLYPV 453


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score = 76.8 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 16/91 (17%), Positives = 37/91 (40%), Gaps = 7/91 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     +    SR   E+LL   G+ G +++R  +S PG + + V ++  +  ++V +  
Sbjct: 53  IQTPRWFQENASRSAAEELLRHKGV-GEFVIRGCQSSPGEFSISVRHESDVQHFKVMRDS 111

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
            G +            F  +  L+  ++   
Sbjct: 112 RGQYFL------WSEKFTSLNKLVDFYRTSS 136


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_O88890 SH2 domain-containing protein 1A n=11 Tax=Eutele...   150   1e-35
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   149   4e-35
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          148   4e-35
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   148   4e-35
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   148   6e-35
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          148   6e-35
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   145   4e-34
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   143   2e-33
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   140   1e-32
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   140   1e-32
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   140   1e-32
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   140   2e-32
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   139   2e-32
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   139   2e-32
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   139   3e-32
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   138   6e-32
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   137   7e-32
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   137   8e-32
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   136   2e-31
UniRef50_O60880 SH2 domain-containing protein 1A n=36 Tax=root R...   136   2e-31
UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosph...   136   2e-31
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   136   2e-31
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   136   2e-31
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   136   2e-31
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   136   3e-31
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   134   6e-31
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   134   6e-31
UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   134   1e-30
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   133   2e-30
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   133   2e-30
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   132   2e-30
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   131   6e-30
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   131   8e-30
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   131   9e-30
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...   130   1e-29
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   130   1e-29
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   130   1e-29
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   130   2e-29
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   129   2e-29
UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   129   2e-29
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   129   3e-29
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   129   3e-29
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   129   3e-29
UniRef50_UPI00003A9BD4 PREDICTED: similar to SH2 domain-containi...   129   3e-29
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   128   5e-29
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   128   5e-29
UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun seq...   128   6e-29
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   127   1e-28
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   127   1e-28
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   127   1e-28
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN         125   4e-28
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   125   4e-28
UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa ...   125   5e-28
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   125   5e-28
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...   124   6e-28
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...   124   6e-28
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   124   1e-27
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...   123   2e-27
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   123   2e-27
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   123   2e-27
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   123   2e-27
UniRef50_O14796 SH2 domain-containing protein 1B n=17 Tax=Theria...   123   2e-27
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   123   2e-27
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...   123   2e-27
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   123   2e-27
UniRef50_UPI0000F2E785 PREDICTED: hypothetical protein n=1 Tax=M...   122   3e-27
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   122   3e-27
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...   122   3e-27
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...   122   4e-27
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   122   4e-27
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   121   6e-27
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   121   8e-27
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   121   9e-27
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   120   1e-26
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   120   1e-26
UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=...   120   1e-26
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   120   2e-26
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   119   2e-26
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   119   2e-26
UniRef50_UPI0000EAFFB4 SH2 domain-containing protein 1B (EWS/FLI...   119   3e-26
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   119   3e-26
UniRef50_UPI00016E9D38 UPI00016E9D38 related cluster n=1 Tax=Tak...   119   3e-26
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   119   3e-26
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...   119   3e-26
UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS         119   3e-26
UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tet...   118   4e-26
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     118   5e-26
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   118   7e-26
UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostom...   117   9e-26
UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine ki...   117   1e-25
UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound p...   117   1e-25
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   116   2e-25
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   116   2e-25
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...   116   2e-25
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...   116   3e-25
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   116   3e-25
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   115   4e-25
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...   115   4e-25
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...   114   6e-25
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE        114   6e-25
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...   114   8e-25
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   114   9e-25
UniRef50_O15357 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...   114   9e-25
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...   114   1e-24
UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_...   114   1e-24
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   113   2e-24
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...   113   2e-24
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   112   3e-24
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   112   3e-24
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...   112   3e-24
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...   112   3e-24
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   112   4e-24
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...   112   4e-24
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...   111   5e-24
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   111   8e-24
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...   111   8e-24
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...   111   9e-24
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...   111   9e-24
UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepI...   111   1e-23
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS         111   1e-23
UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q...   111   1e-23
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...   110   1e-23
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   110   2e-23
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   110   2e-23
UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Tak...   110   2e-23
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   110   2e-23
UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=...   110   2e-23
UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2...   109   2e-23
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...   109   2e-23
UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 ...   109   3e-23
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   109   3e-23
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...   109   3e-23
UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleos...   109   4e-23
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   109   4e-23
UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=...   109   4e-23
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   108   5e-23
UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichop...   108   5e-23
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   108   6e-23
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...   108   6e-23
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...   108   6e-23
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...   107   7e-23
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   107   7e-23
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...   107   8e-23
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...   107   9e-23
UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax...   107   1e-22
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...   107   1e-22
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...   107   1e-22
UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n...   107   1e-22
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   106   2e-22
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...   106   2e-22
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...   106   2e-22
UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A...   106   2e-22
UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun se...   106   3e-22
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   106   3e-22
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...   106   3e-22
UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus...   106   3e-22
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...   106   3e-22
UniRef50_C1BZH2 SH2 domain-containing protein 1A n=3 Tax=Euteleo...   105   4e-22
UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (...   105   5e-22
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...   105   5e-22
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...   105   5e-22
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...   105   6e-22
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...   104   7e-22
UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_S...   104   7e-22
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...   104   7e-22
UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X...   104   7e-22
UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis R...   104   7e-22
UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_D...   104   8e-22
UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=T...   104   8e-22
UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra...   104   8e-22
UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichop...   104   9e-22
UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis R...   104   9e-22
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...   104   1e-21
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME        104   1e-21
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...   104   1e-21
UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...   104   1e-21
UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n...   104   1e-21
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   104   1e-21
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...   104   1e-21
UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=...   104   1e-21
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   104   1e-21
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...   104   1e-21
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...   104   1e-21
UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=...   103   1e-21
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   103   2e-21
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...   103   2e-21
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...   103   2e-21
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...   103   2e-21
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...   103   2e-21
UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicin...   103   2e-21
UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_...   103   2e-21
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...   103   2e-21
UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome ...   103   2e-21
UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n...   102   2e-21
UniRef50_Q29CU6 GA13993 n=10 Tax=Neoptera RepID=Q29CU6_DROPS          102   2e-21
UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain pr...   102   2e-21
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   102   2e-21
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS         102   2e-21
UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni Re...   102   3e-21
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...   102   3e-21
UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU...   102   3e-21
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI         102   3e-21
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...   102   3e-21
UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS         102   3e-21
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...   102   3e-21
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...   102   3e-21
UniRef50_Q9VXH3 Small wing n=17 Tax=Drosophila RepID=Q9VXH3_DROME     102   3e-21
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME       102   3e-21
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...   102   4e-21
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...   102   4e-21
UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=...   102   4e-21
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...   102   4e-21
UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, part...   102   4e-21
UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   102   4e-21
UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specif...   102   5e-21
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...   102   5e-21
UniRef50_Q9XYM0 Adapter molecule Crk n=8 Tax=Endopterygota RepID...   101   5e-21
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...   101   5e-21
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   101   6e-21
UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=...   101   6e-21
UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=...   101   6e-21
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...   101   6e-21
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...   101   6e-21
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...   101   6e-21
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   101   7e-21
UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 ...   101   7e-21
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...   101   7e-21
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   101   7e-21
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...   101   8e-21
UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi Rep...   101   8e-21
UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepI...   101   8e-21
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...   101   8e-21
UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID...   101   8e-21
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...   101   8e-21
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...   101   1e-20
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...   101   1e-20
UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Tak...   100   1e-20
UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pe...   100   1e-20
UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY3...   100   1e-20
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...   100   1e-20
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...   100   1e-20
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...   100   1e-20
UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 ...   100   1e-20
UniRef50_A8Q2Q3 SH2 domain containing protein n=1 Tax=Brugia mal...   100   2e-20
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...   100   2e-20
UniRef50_UPI000180BA50 PREDICTED: similar to growth factor recep...   100   2e-20
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...   100   2e-20
UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=S...   100   2e-20
UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...   100   2e-20
UniRef50_Q4SKC0 Chromosome 13 SCAF14566, whole genome shotgun se...   100   2e-20

Sequences not found previously or not previously below threshold:

>UniRef50_O88890 SH2 domain-containing protein 1A n=11 Tax=Euteleostomi
           RepID=SH21A_MOUSE
          Length = 126

 Score =  150 bits (380), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 126/126 (100%), Positives = 126/126 (100%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE
Sbjct: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD
Sbjct: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120

Query: 121 ICLNAP 126
           ICLNAP
Sbjct: 121 ICLNAP 126


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  149 bits (376), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y G +Y YR+S+  
Sbjct: 268 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDP 326

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ--KPDQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+          G++TPL YP  K +            
Sbjct: 327 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 381

Query: 118 DSDIC 122
           + +IC
Sbjct: 382 EWEIC 386


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  148 bits (375), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 248 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 306

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ--KPDQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+          G++TPL YP  K +            
Sbjct: 307 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 361

Query: 118 DSDIC 122
           + +IC
Sbjct: 362 EWEIC 366


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  148 bits (375), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 249 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 307

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ--KPDQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+          G++TPL YP  K +            
Sbjct: 308 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 362

Query: 118 DSDIC 122
           + +IC
Sbjct: 363 EWEIC 367


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  148 bits (374), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y G +Y YR+S+  
Sbjct: 192 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDS 250

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ--KPDQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+          G++TPL YP  K +            
Sbjct: 251 DGKVYV-----TAEAKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 305

Query: 118 DSDIC 122
           + +IC
Sbjct: 306 EWEIC 310


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  148 bits (373), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 9/125 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 257 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 315

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ--KPDQGIVTPLQYPVEKSSGRGP-QAPTGRR 117
            G           +  F  +  L+          G++TPL YP  K +            
Sbjct: 316 DGKVFV-----TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPD 370

Query: 118 DSDIC 122
           + +IC
Sbjct: 371 EWEIC 375


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  145 bits (366), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 32/127 (25%), Positives = 54/127 (42%), Gaps = 13/127 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLY----QGYIYTYR 55
           M+    +   ISR    + L+A G   GS+L+R+SE+ PG Y L +         +  YR
Sbjct: 111 METEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFDNNGDGVKHYR 170

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           +   + G +   T        F  +K L+  + +   G+ T L  P +      PQ P  
Sbjct: 171 IRNMDNGGFYITTKIS-----FNSLKELVQHYSRDSDGLCTKLVKPCQSK---APQKPWW 222

Query: 116 RRDSDIC 122
           + + +I 
Sbjct: 223 QDEWEIP 229


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  143 bits (361), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 8/123 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT- 59
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+++  
Sbjct: 169 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDT 227

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP-QAPTGRRD 118
             G     T     +  F  +  L+        G++T L YP  K +            +
Sbjct: 228 SDGKVYVTT-----ESRFNTLAELVHHHSMHSDGLITQLLYPAPKHNKPTVFALSPEPDE 282

Query: 119 SDI 121
            +I
Sbjct: 283 WEI 285


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  140 bits (354), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 59/123 (47%), Gaps = 9/123 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++ ++GS+L+R+SES PG   + + Y+G +Y YR++ T 
Sbjct: 168 LEKHSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP---VEKSSGRGPQAPTGRR 117
            G           +  F  +  L+        G+VT L YP     K +  G      + 
Sbjct: 227 DGKVYV-----TAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281

Query: 118 DSD 120
           + +
Sbjct: 282 EME 284


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  140 bits (354), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 32/122 (26%), Positives = 58/122 (47%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 8   LEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 66

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-PTGRRDS 119
            G     +     +  F  +  L+        G++T L YP  K +              
Sbjct: 67  DGKLYVSS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKW 121

Query: 120 DI 121
           ++
Sbjct: 122 EM 123


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  140 bits (354), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 8/124 (6%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   Y GKI R   EK LLL     G++L+RDSES    + L V     +  YR+ Q 
Sbjct: 142 IEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFSLSVRDGDTVKHYRIRQL 201

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ--APTGRR 117
           + G +         +  FR ++ L+  +     G+   L+ P  +         + + R 
Sbjct: 202 DEGGFFIAR-----RTTFRTLQELVDHYGNEADGLCVNLRKPCVQVEKPMTSGLSHSTRD 256

Query: 118 DSDI 121
             +I
Sbjct: 257 QWEI 260


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  140 bits (353), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 32/122 (26%), Positives = 58/122 (47%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 122 LEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-PTGRRDS 119
            G     +     +  F  +  L+        G++T L YP  K +              
Sbjct: 181 DGKLYVSS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235

Query: 120 DI 121
           ++
Sbjct: 236 EM 237


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  139 bits (352), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 32/122 (26%), Positives = 58/122 (47%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 374 LEKHSWYHGPVSRNAAEHLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 432

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-PTGRRDS 119
            G     +     +  F  +  L+        G++T L YP  K +              
Sbjct: 433 DGKLYVSS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPSVYGVSPNYDKW 487

Query: 120 DI 121
           ++
Sbjct: 488 EM 489


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  139 bits (352), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 52/125 (41%), Gaps = 8/125 (6%)

Query: 1   MDAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   Y  KI R   EK LLL     G++L+RDSES    Y L V     +  YR+ Q 
Sbjct: 125 IEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQL 184

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ--APTGRR 117
           + G +         +  FR ++ L+  + K   G+   L  P  +      +  +   R 
Sbjct: 185 DEGGFFIAR-----RTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRD 239

Query: 118 DSDIC 122
             +I 
Sbjct: 240 QWEID 244


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  139 bits (351), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 38/122 (31%), Positives = 59/122 (48%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G+DGS+L+RDSES PG   + + + G +Y YR+S   
Sbjct: 182 LEKHSWYHGPISRNAAEYLL-SSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGS 240

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-PTGRRDS 119
            G     T     +  F  +  L+    K   G++T L+YP  K              + 
Sbjct: 241 DGKVFVTT-----ESKFSTIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLPDEW 295

Query: 120 DI 121
           +I
Sbjct: 296 EI 297


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  138 bits (348), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 6/108 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HG+ISRE  EKLL     +G +L+R+S++ PG Y LCV Y G +  YRV + E
Sbjct: 104 LKTMPWFHGRISREDAEKLLTP-PKNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNE 162

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
            G  + +        +F  +  L+  +QK   G+ T L+ PV+K    
Sbjct: 163 KGLVTVDD-----DEYFDNLIKLVEHYQKEADGLCTRLKAPVDKEGQH 205


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  137 bits (347), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 68/120 (56%), Gaps = 7/120 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D+   YHG+I R T E  L + G++GS+L+R+S+S  G + + +   G ++ YR+S+T+
Sbjct: 174 LDSEPYYHGRIPRTTAEFFL-SNGINGSFLVRESQSNAGEHTISLRCDGKVFHYRISRTD 232

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G + A        R F  V++L+  + +   G+V PL++ V K+      +P+ + + D
Sbjct: 233 KGVFIAA------DRVFSTVQDLVKFYHQQSDGLVHPLRHAVPKNRQEITASPSDKWEID 286


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  137 bits (347), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 6/122 (4%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     YHG+ISR   E+LL   G   GS+L+RDS +  G Y L + +QG  Y Y +S+ 
Sbjct: 4   LSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISRH 63

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
             GS + +         F     LI    K   G++T L+ P  +  G+ PQ        
Sbjct: 64  PDGSVAIQDGA-----KFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQGYRFISHE 118

Query: 120 DI 121
           ++
Sbjct: 119 EM 120



 Score = 97.9 bits (243), Expect = 9e-20,   Method: Composition-based stats.
 Identities = 28/115 (24%), Positives = 47/115 (40%), Gaps = 9/115 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                +HG ISRE  E+ + A G  DG +L+R+  +    + LCV  +  IY Y +    
Sbjct: 159 RKQLWFHGAISREESEQRMKAFGLRDGLFLVRER-TEVNSFALCVAVKNDIYHYLLEMNT 217

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY--PVEKSSGRGPQAP 113
            G  S E       R F  +  ++  + +   G++  L     V +   +    P
Sbjct: 218 LGQLSIENG-----RKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMP 267


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  136 bits (344), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 38/122 (31%), Positives = 62/122 (50%), Gaps = 8/122 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  +HGKISRE  E LL+    DG +L+R+S   PG Y LCV +Q  +  YR+ Q + G 
Sbjct: 99  MPWFHGKISRELAESLLMPR-EDGLFLVRESAHFPGDYTLCVCFQDQVDHYRM-QGKNGK 156

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ-APTGRRDSDIC 122
            + +      + +F  ++ L+  ++K   G+ T L+ PV K  GR  +       + +I 
Sbjct: 157 LTID-----EEVYFSSLEELVQHYEKDADGLCTRLRKPVVKQGGREFKIDARKFVNWEIS 211

Query: 123 LN 124
             
Sbjct: 212 PR 213


>UniRef50_O60880 SH2 domain-containing protein 1A n=36 Tax=root RepID=SH21A_HUMAN
          Length = 128

 Score =  136 bits (344), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 111/128 (86%), Positives = 115/128 (89%), Gaps = 2/128 (1%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MDAV VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY GYIYTYRVSQTE
Sbjct: 1   MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV-EKSSGRGPQAPTG-RRD 118
           TGSWSAETAPGVHKR+FRK+KNLISAFQKPDQGIV PLQYPV +KSS R  Q  TG R D
Sbjct: 61  TGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIRED 120

Query: 119 SDICLNAP 126
            D+CL AP
Sbjct: 121 PDVCLKAP 128


>UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosphate 5- phosphatase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BC71
          Length = 1019

 Score =  136 bits (343), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 44/121 (36%), Positives = 65/121 (53%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
               HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY   +YTYR+   +   
Sbjct: 3   HCWNHGNITRSKAEELLSKTGKDGSFLVRASESISRAYALCVLYHNCVYTYRILPNDDEK 62

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICL 123
           ++ + + GV  RFF  ++ LI  ++K + G+VT LQYPV+         P    +  +  
Sbjct: 63  FTVQASEGVPMRFFTSLEQLIDFYKKENMGLVTHLQYPVQLEEEDAADDPEEETEFIMSP 122

Query: 124 N 124
            
Sbjct: 123 P 123


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  136 bits (343), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 32/122 (26%), Positives = 58/122 (47%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG +SR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR++   
Sbjct: 461 LEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 519

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-PTGRRDS 119
            G     +     +  F  +  L+        G++T L YP  K +              
Sbjct: 520 DGKLYVSS-----ESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 574

Query: 120 DI 121
           ++
Sbjct: 575 EM 576


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  136 bits (343), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 8/124 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +DA   + GKI R   EK+L  +    GS+L+RDSE+ PG + L V  Q  +  YRV + 
Sbjct: 117 LDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRL 176

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP--TGRR 117
           E GS          +  F+ +  L+  ++    G+   L YP  ++              
Sbjct: 177 EDGSLFV-----TRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAGLLRQANE 231

Query: 118 DSDI 121
           + +I
Sbjct: 232 EWEI 235


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  136 bits (343), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    + G+ISR     +L  T  +G +L+R+SE+ PG Y L + +   +  YR+    
Sbjct: 340 LEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEGVRHYRIQHI- 398

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G +            F  +  LI   +    GIVT L+  +  ++        G    +
Sbjct: 399 EGQYFVN-----ENHRFDSIPQLIEYHKLNGGGIVTRLRRAINDANAPISVGL-GHDMWE 452

Query: 121 IC 122
           + 
Sbjct: 453 LS 454


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  136 bits (342), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 30/122 (24%), Positives = 54/122 (44%), Gaps = 7/122 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   +    S+     LL   G DG++L+R+SES PG Y L V YQG +  Y++   +
Sbjct: 277 LESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLSVFYQGKLKHYKIKHDQ 336

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
              +         +  F  +  LI   +    G+VT L+ PV+ ++        G    +
Sbjct: 337 D-MYRVS-----ERHTFASISELIEYHKHNGGGLVTRLRKPVQDANTPITAGL-GHDRWE 389

Query: 121 IC 122
           + 
Sbjct: 390 LD 391


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  134 bits (339), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 36/124 (29%), Positives = 59/124 (47%), Gaps = 10/124 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   YHG I R   E LL  +G+ GS+L+R+SES PG   + + Y+G I+ YR+ + +
Sbjct: 162 LESEKWYHGAIQRSYAEYLL-NSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDD 220

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK----SSGRGPQAPTGR 116
           +  +       +    F  V +L+   +K   G+   L YP  K    SS          
Sbjct: 221 SNMYYV-----IESNKFTSVSDLVHHHEKHSDGLACTLLYPAPKRDRTSSELRMDPSFDI 275

Query: 117 RDSD 120
           R+ D
Sbjct: 276 REID 279


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  134 bits (339), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 53/125 (42%), Gaps = 6/125 (4%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   + GKI+R   EK L       GS+L+R+SES PG Y L +     +  YRV   
Sbjct: 232 LESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRDGDTVRHYRVENY 291

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR--GPQAPTGRR 117
           E G +  +   G   + F  +  LI+   +   G+ T L+ P  K S             
Sbjct: 292 EGGLYKLQ---GSPTQKFASLPELIAFHGQRKAGLATALREPCPKESAPMASDLTFDTHD 348

Query: 118 DSDIC 122
             ++ 
Sbjct: 349 QWEVP 353


>UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2B n=7
           Tax=Clupeocephala RepID=SHP2B_DANRE
          Length = 1226

 Score =  134 bits (337), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 47/118 (39%), Positives = 70/118 (59%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YH  ISR   E+LL   G+DGS+L+RDSESVPG Y LC+L+Q +++TYR+    
Sbjct: 1   MTGAPWYHRDISRVRAEELLAHAGIDGSFLVRDSESVPGAYALCLLFQRHVHTYRILPDA 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            G  + +   GV    FR + +L+  +Q P++G+V PL YPV + S    ++  G  +
Sbjct: 61  DGLLAVQATQGVQVNCFRTLGDLVLGYQNPNKGLVAPLLYPVMRESEANDESSDGDDE 118


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  133 bits (336), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 29/128 (22%), Positives = 54/128 (42%), Gaps = 14/128 (10%)

Query: 1   MDAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVL-----YQGYIYTY 54
           M+    ++  +SR     +LL      GS+L+R+SE+ PG + + V          I  Y
Sbjct: 115 METEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHY 174

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           R+   + G +        +K  F  +  L+  + +   G+ T L  P +    R PQ P 
Sbjct: 175 RIRNMDAGGFYI-----TNKISFNSLSELVKHYSREADGLCTRLVKPCQ---TRAPQKPW 226

Query: 115 GRRDSDIC 122
            + + ++ 
Sbjct: 227 WQDEWEVP 234


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  133 bits (335), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 8/125 (6%)

Query: 1   MDAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           + A   + G I R   E +LL +    GS+L+R+SES  G + L VL    +  YR+ + 
Sbjct: 111 LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRL 170

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP--QAPTGRR 117
           + G +         +R F  +   +S + K   G+   L  P  K     P   +     
Sbjct: 171 DEGGFFL-----TRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVD 225

Query: 118 DSDIC 122
             +I 
Sbjct: 226 QWEID 230


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  132 bits (334), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D  T YHGKISR   E +L  +G+ GS+L+R+SE+  G Y + V + G ++ YR++   
Sbjct: 189 LDKYTWYHGKISRSDSEAIL-GSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDN 247

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           T            +  FR +  L+        G++  L YP  K          GR    
Sbjct: 248 TEKMFI-----TQEVKFRTLGELVHHHSVHADGLICLLMYPASKK-------DKGRGLFS 295

Query: 121 ICLNAP 126
           +  NAP
Sbjct: 296 LSPNAP 301


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  131 bits (331), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 30/123 (24%), Positives = 50/123 (40%), Gaps = 7/123 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   Y GK+SR   +  L    LDG++L+R+SE+  G Y L V + G    YR+     
Sbjct: 254 ESEPWYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYRIQHDGN 313

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDI 121
             +         +   + +K LI   +    G+ T L+ P        P    G    +I
Sbjct: 314 EYYI------TTRHRQKTIKELIDYHKLNGGGLCTRLKKPACDDEAPTPHDL-GSDKWEI 366

Query: 122 CLN 124
             +
Sbjct: 367 DPS 369


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  131 bits (329), Expect = 8e-30,   Method: Composition-based stats.
 Identities = 27/123 (21%), Positives = 51/123 (41%), Gaps = 5/123 (4%)

Query: 1   MDAVTVYHGKISRETGEKLL-LATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           ++A   + G I+R   EKLL +     G +L+R+SES PG + L +     +  +RV + 
Sbjct: 336 LEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGENVRHFRVKKV 395

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
             G        G      + + +LI   ++   G+ T L+ P  +           +   
Sbjct: 396 AGG----IKLQGSPSSPHKDLPSLIKYHKRHRGGLTTTLKVPCPREIRAPDIGYAVKDKW 451

Query: 120 DIC 122
           ++ 
Sbjct: 452 EVD 454


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  131 bits (329), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 30/122 (24%), Positives = 50/122 (40%), Gaps = 8/122 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +A   Y G + R   EK L+  G   G++L+R +E+  G + L V     +  YRV + +
Sbjct: 122 EAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLSVRDGDSVKHYRVRKLD 181

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           TG +   T     +  F  +  L+  + K   G+V  L  P  K           +   +
Sbjct: 182 TGGYFITT-----RAPFNSLYELVQHYTKDADGLVCALTLPCPKDKPV--TGGIAKDAWE 234

Query: 121 IC 122
           I 
Sbjct: 235 IP 236


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score =  130 bits (328), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 39/117 (33%), Positives = 64/117 (54%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YHG+++R+  E+LLL+  +DGS+++R SES  G Y L VL+   ++TYR+  TE
Sbjct: 1   MSDEIWYHGRVNRQQSEELLLSAAVDGSFVVRASESRAGAYALSVLFNNSVHTYRILPTE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
             + + +T  GV +R F+ +  L+  ++    G+V  L  PV   S   P   +   
Sbjct: 61  NNTLAVQTVNGVQQRKFKSLTELVHEYRNSQNGLVCGLSNPVGLDSKTRPSTSSAFD 117


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  130 bits (327), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 26/127 (20%), Positives = 50/127 (39%), Gaps = 13/127 (10%)

Query: 1   MDAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVL----YQGYIYTYR 55
           ++    +     R+  E +LL      GS+L+R+SE+  G + L V         I  Y+
Sbjct: 119 LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYK 178

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
           +   + G +         +  F  ++ L+  + K   G+   L  P  +     PQ P  
Sbjct: 179 IRCLDEGGYYIS-----PRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP---APQNPWA 230

Query: 116 RRDSDIC 122
           + + +I 
Sbjct: 231 QDEWEIP 237


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  130 bits (327), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 33/132 (25%), Positives = 53/132 (40%), Gaps = 15/132 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPG----VYCLCVLYQGYIYTYR 55
           ++A   Y G I R   EKLL+  G  DGS+L+R SE+  G     + L V  +  I  YR
Sbjct: 124 LEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVRDKELIRHYR 183

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK-----SSGRGP 110
           +  T++G +          + F  +  LI  ++    G+   L  P  K           
Sbjct: 184 IKITDSGKYFISL-----SKEFSTLNELIEFYKISSDGLKIKLLEPCRKVCIMFKKQVQT 238

Query: 111 QAPTGRRDSDIC 122
              + +   +I 
Sbjct: 239 FGLSHKDKWEIS 250


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  130 bits (327), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 7/116 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + A+  +HGKI+R   E LL     DG +L+R+S + PG Y +CV + G +  YRV   +
Sbjct: 103 LTAMPWFHGKITRSDAEDLLTPR-KDGLFLVRESTNYPGDYTMCVSFAGEVEHYRVIF-K 160

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
               + +      + +F  +  L+  +++   G+V  L  P+ K  G      T  
Sbjct: 161 DNKVTID-----EEEYFENLTKLVEHYERDADGLVCTLTQPLIKKGGHEYSVDTEE 211


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  129 bits (326), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 30/128 (23%), Positives = 52/128 (40%), Gaps = 14/128 (10%)

Query: 1   MDAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           M+    ++  I+R+  E +LL      GSYL+R+SE+  G Y L +       Q  +  Y
Sbjct: 122 METEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHY 181

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           ++   + G +         K  F  + ++I  + K   G+   L    EK      Q P 
Sbjct: 182 KIRSLDNGGYYIS-----PKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKA---QKPW 233

Query: 115 GRRDSDIC 122
            +   +I 
Sbjct: 234 DKDAWEIS 241


>UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 n=40
           Tax=Euteleostomi RepID=SHIP1_HUMAN
          Length = 1189

 Score =  129 bits (326), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 47/120 (39%), Positives = 66/120 (55%), Gaps = 1/120 (0%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
             HG I+R   E+LL  TG DGS+L+R SES+   Y LCVLY+  +YTYR+   E   ++
Sbjct: 5   WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR-DSDICLN 124
            + + GV  RFF K+  LI  ++K + G+VT LQYPV          P     +S +   
Sbjct: 65  VQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESVVSPP 124


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  129 bits (325), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 28/129 (21%), Positives = 54/129 (41%), Gaps = 12/129 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           + A   Y GK+ R+  E+ LL+ G   G++L+R+SE+  G Y L +         ++  Y
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY 203

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP- 113
           ++ + + G +   T        F  ++ L+  + +   G+   L  P  K   R      
Sbjct: 204 KIRKLDNGGYYITTRAQ-----FETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSV 258

Query: 114 TGRRDSDIC 122
             +   +I 
Sbjct: 259 KTKDVWEIP 267


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  129 bits (325), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 6/111 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG +SR+ GE LL + G+ GS+L+R SES PG   + V + G +Y YR+SQ   G 
Sbjct: 239 YSWYHGAVSRQAGEHLLRS-GITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGL 297

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           +            F  V  LI    +   G+V PL Y V K          
Sbjct: 298 FYI-----TEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQ 343


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  129 bits (324), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 7/123 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  T YHG +SR   E LL ++G++GS+L+RDSES  G   + V +   +Y YR++   
Sbjct: 82  LNMHTWYHGAVSRAAAEYLL-SSGINGSFLVRDSESCRGHLSVSVRFNASVYHYRINVDT 140

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP-QAPTGRRDS 119
            G +         +  F+ +  L+        G+   L YP  KS+            + 
Sbjct: 141 AGLFYIS-----PEHRFQTLPELVHHHSYASDGLAAILHYPAAKSTKPAVYSMAPDYDEW 195

Query: 120 DIC 122
           +I 
Sbjct: 196 EID 198


>UniRef50_UPI00003A9BD4 PREDICTED: similar to SH2 domain-containing molecule EAT2 n=2
           Tax=Neognathae RepID=UPI00003A9BD4
          Length = 134

 Score =  129 bits (324), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 54/116 (46%), Positives = 79/116 (68%), Gaps = 2/116 (1%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             +HGKISR+  E LL   G +GSYL+R+SE+V G  CLCVL++  IYTYR+ +   G +
Sbjct: 4   PFFHGKISRKACEDLLCKKGKNGSYLIRESETVAGALCLCVLFEKVIYTYRIFREYEGCY 63

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK--SSGRGPQAPTGRRD 118
             +T+ GV ++ F+ +K+LI  ++KP+QG+VT L+YPV+K  SS R  +  TG  D
Sbjct: 64  KVQTSEGVPQKVFKTLKDLIYNYEKPNQGLVTKLRYPVKKTSSSRRSQRFKTGNDD 119


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  128 bits (323), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 6/117 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           + +  +HGKISRE  E++L   G DG +L+R+S S  G Y L VL++G +  Y + +   
Sbjct: 5   ENLCWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGD 64

Query: 62  G-SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
              +S      +H      + +LI  +QK    +VT LQ               G  
Sbjct: 65  DAFFSIHDHTPIH-----GLDSLIEHYQKDKGNLVTRLQVICRSDPPPHDVRSHGTT 116



 Score = 76.0 bits (186), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 24/142 (16%), Positives = 42/142 (29%), Gaps = 43/142 (30%)

Query: 6   VYHGKISRETGEKLL----------------------------------LATGLDGSYLL 31
            YHG + R      L                                  L     G+YL+
Sbjct: 284 WYHGTLERTAAVDYLKDFAVKLLPNLAHRQQQQQPDRDGNKENGECLDGLEQSTSGTYLV 343

Query: 32  RDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
           R S        L +LY      + + + +      +  P     +   +++LI  + +  
Sbjct: 344 RYSAKQNVD-VLTMLYDNEPKHFIIQRQQD-WLYIDEGP-----YMNSLEHLIEHYTRFS 396

Query: 92  QGIVTPLQYPVEKSSGRGPQAP 113
            G+   L++PV    G  P  P
Sbjct: 397 DGLPINLRFPVT--PGPKPPIP 416


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  128 bits (323), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 28/105 (26%), Positives = 48/105 (45%), Gaps = 7/105 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG+I RE  E LL     DG +L+R+S + PG Y LCV +   +  YR+    
Sbjct: 373 LNAMPWFHGRIKREEAENLLKPR-EDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKY-A 430

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
               + +        +F  +  L+  +     G+ T L   + K 
Sbjct: 431 ENKLTIDD-----DEYFDNLGQLVEHYTLDSDGLCTKLMKALPKE 470


>UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RP74_TETNG
          Length = 968

 Score =  128 bits (322), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 47/122 (38%), Positives = 71/122 (58%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     YH  ISR   E+LL   G DGSYL+RDSESVPG Y LC+L+Q +++TYR+    
Sbjct: 9   MATAVWYHRDISRVQAEELLARAGKDGSYLVRDSESVPGAYALCLLFQRHVHTYRILPDA 68

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G  + +T  GV    FR +++L+  +Q+P +G+V+PL Y V +    G ++    +   
Sbjct: 69  DGLLAVQTTQGVQVNCFRTLEDLVFGYQQPHKGLVSPLLYGVPRDMDIGDESSDDEKPPP 128

Query: 121 IC 122
           + 
Sbjct: 129 VS 130


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  127 bits (320), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 7/124 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HGKI+RE  E+LL      G +L+R+S + PG Y LCV   G +  YR+    
Sbjct: 77  LSLMPWFHGKITREQAERLLYP-PETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIM--- 132

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
              + A       + +F  +  L+  +     G+ T L  P         Q    R    
Sbjct: 133 ---YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWA 189

Query: 121 ICLN 124
           + + 
Sbjct: 190 LNMK 193


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 32/110 (29%), Positives = 55/110 (50%), Gaps = 9/110 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           +  +  + GKI+RE  E+LL    + G +L+R+S + PG Y LCV+       +  YRV 
Sbjct: 87  LHEMPWFFGKITREKAEELLTPREV-GLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 145

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
            T     + +      + FF  +  LI  ++K   G+ T L+ P++K + 
Sbjct: 146 STSDNQVTVD-----EEAFFPTLIELIKHYEKDADGLCTMLKKPLKKKTE 190


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 28/123 (22%), Positives = 54/123 (43%), Gaps = 7/123 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D+   +  ++SR   E +L   G +G +++R+S S   +Y L + ++G +  Y +   E
Sbjct: 313 LDSEEWFFPQLSRTRAENILKGEGREGGFVVRNS-SRENMYTLSICHEGQVRHYHIKLDE 371

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY-PVEKSSGRGPQAPTGRRDS 119
           +  +         K  F  +K LI   +    G+VT L+  PV+ +       P      
Sbjct: 372 SNKYFIS-----EKHRFPSIKELIEYHKLNGGGLVTRLRKPPVQLAPNPQSLGPLFDEAW 426

Query: 120 DIC 122
           +I 
Sbjct: 427 EID 429


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 50/114 (43%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +++  +HG +SRE  + LL     DG++L+R+S +  G + L +L Q  +  Y+V +   
Sbjct: 6   ESMKWFHGNLSREAADDLLKQGYEDGTFLVRESSTAAGDFVLSLLCQEEVCHYQVRRHGG 65

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
                     V  +    +  L+  +Q+   G+ T L  P+ +          G
Sbjct: 66  EDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDPPPHNTRSHG 119



 Score = 84.1 bits (207), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 25/129 (19%), Positives = 44/129 (34%), Gaps = 19/129 (14%)

Query: 4   VTVYHGKISRETGEKLLLATGLD-----------GSYLLRDSESVPGV-YCLCVLYQGYI 51
              YHG  SRE     L     +           G +L+R SES       L +      
Sbjct: 286 EQWYHGTQSREEAVANLKKFAKELESKNPQIDTSGCFLVRYSESAAATGLVLTLFCDQVA 345

Query: 52  YTYRVSQTE--TGSWSAETA-----PGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
             +R+SQ +        ++            ++  +++LI+ F +   G+   L+YPV  
Sbjct: 346 KNFRISQADLYQNGVKLQSGGSKFLYIDDGPYWPSLEHLIAHFMRFSYGLPVSLKYPVPP 405

Query: 105 SSGRGPQAP 113
                  + 
Sbjct: 406 LPKPEVPSF 414


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 28/128 (21%), Positives = 52/128 (40%), Gaps = 13/128 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           + A   Y GK+ R+  E+LLL  G   G +L+R+SE+  G Y L +          +  Y
Sbjct: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHY 212

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           ++ + + G +   T        F  ++ L+  + +   G+   L   V  +     Q   
Sbjct: 213 KIRKLDNGGYYITTRAQ-----FDTLQKLVKHYTEHADGLCHKLTT-VCPTVKPQTQGL- 265

Query: 115 GRRDSDIC 122
            +   +I 
Sbjct: 266 AKDAWEIP 273


>UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa RepID=O77440_HYDAT
          Length = 624

 Score =  125 bits (314), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 34/119 (28%), Positives = 52/119 (43%), Gaps = 7/119 (5%)

Query: 6   VYHGKISRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            +HG+I+R+  E  L  T    DG+YLLR+S S  G Y L V     +  Y + +  +G 
Sbjct: 9   WFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSVCKDKKVIHYAIQRQPSGM 68

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDIC 122
                 P      F     L++  +    G++T L YP E+ +G    A  G    D+ 
Sbjct: 69  VGIADGPQ-----FPGPVELVNHHKTSLGGLMTKLTYPCERPAGVKATAYKGISHDDLD 122



 Score =  106 bits (265), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 23/101 (22%), Positives = 43/101 (42%), Gaps = 5/101 (4%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
                +HG I R   E+ L +    G +L+R+  S  G Y + + YQG +Y Y       
Sbjct: 157 RQQPWFHGVIPRTEAERRLKSLSETGMFLIRERGSPRGSYVIGLFYQGGVYHYLFESNNQ 216

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           G  S ++      R F  +  +++ + +  +G+   L+   
Sbjct: 217 GQLSIKSG-----RSFDNLMAVVNFYSQKSEGLFCTLKRAC 252


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  125 bits (314), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 26/123 (21%), Positives = 49/123 (39%), Gaps = 7/123 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   +HG+ISR     LL     +G +L+R+SES  G Y L V +   +  Y + +  
Sbjct: 297 IESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGEYSLSVSHGDSLRHYHIKKEG 356

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
              +  +      +  F  +  LI   +    G+VT L+  +            G    +
Sbjct: 357 EEFYIND------RHRFPDICKLIEYHKLNSGGLVTRLRKSIADLHTPAAAGL-GHGKWE 409

Query: 121 ICL 123
           +  
Sbjct: 410 LDP 412


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score =  124 bits (313), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 29/114 (25%), Positives = 51/114 (44%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D +  YHG +SRE  ++LL     DG++L+R+S +  G + L +L QG +  Y+V +   
Sbjct: 6   DPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGG 65

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
                     V  +    +  L+  +Q+   G+ T L  P+ +          G
Sbjct: 66  EDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHG 119



 Score = 97.5 bits (242), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 29/144 (20%), Positives = 52/144 (36%), Gaps = 29/144 (20%)

Query: 6   VYHGKISRETGEKLLLATGLD-----------GSYLLRDSES-VPGVYCLCVLYQGYIYT 53
            YHG ++RE    +L     +           G +L+R SES       L +L    +  
Sbjct: 288 WYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKN 347

Query: 54  YRVSQ------------TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
           +R+SQ              +     +  P     ++  V++LI+ F +   G+   L+YP
Sbjct: 348 FRISQADLYQNGNKVQSGGSKFLYIDDGP-----YWPSVEHLIAHFMRFSYGLPVSLKYP 402

Query: 102 VEKSSGRGPQAPTGRRDSDICLNA 125
           V         +      S++   A
Sbjct: 403 VPPQPKPEVPSFATIPRSNMKPKA 426


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score =  124 bits (313), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 28/134 (20%), Positives = 52/134 (38%), Gaps = 17/134 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY-----IYTYR 55
           ++    YH  I+R   E LL     +G++++RDS    G Y + V          I  Y+
Sbjct: 145 LEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDS-RHLGSYTISVFMGARSTEAAIKHYQ 203

Query: 56  VSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP------VEKSSGRG 109
           + + ++G W         +  F+ +  LI   Q    G++T L+YP         ++   
Sbjct: 204 IKKNDSGQWYV-----AERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGF 258

Query: 110 PQAPTGRRDSDICL 123
                    S++  
Sbjct: 259 SYGKWEIDPSELAF 272


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  124 bits (311), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 10/124 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIY-TYRVSQT 59
           ++    YH  ISR T E LL  +G+DGS+L+R+S S PG Y + +   G     YR++  
Sbjct: 123 INRNPWYHSNISRNTAEYLL-KSGVDGSFLVRESLSSPGEYSITLRCDGKARTHYRINHD 181

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ-YPVEKSSGRGPQAPTGRRD 118
             G + A          F  V+ L++       G+V  L+ +PVEK+  +         +
Sbjct: 182 ARGYFVAAGKF------FATVEQLVAHHAVVADGLVACLKQHPVEKAEAKPLVLSKEEDE 235

Query: 119 -SDI 121
             +I
Sbjct: 236 QWEI 239


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score =  123 bits (310), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 6/111 (5%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG +SR+ GE LL + G+ GS+L+R SES PG   + V + G +Y YR+SQ   G 
Sbjct: 76  YSWYHGAVSRQAGEHLLRS-GITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGL 134

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           +            F  V  LI    +   G+V PL Y V K          
Sbjct: 135 FYI-----TEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQ 180


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 31/101 (30%), Positives = 53/101 (52%), Gaps = 6/101 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +H  ISRE  EKLL     DG++L+R+S + PG + LC+ Y G +  YR+ QT  
Sbjct: 144 NNQPWFHSMISRENTEKLLRGKP-DGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSG 202

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           G  + +      + +F  +  L+S +++   G+   L  P+
Sbjct: 203 GQLTCDK-----EEYFSNLTQLVSHYKRDADGLCHRLVTPI 238


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 7/104 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG I+R+  E LL     DG +L+R+S + PG Y LCV +Q  +  YRV   E
Sbjct: 474 LNAMPWFHGSITRDEAEHLLQPR-EDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 532

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
               + +      + +F  +  L++ ++    G+ T L   + K
Sbjct: 533 N-KLTIDD-----EEYFENLGQLVAHYEADADGLCTQLIKCLPK 570


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 6/108 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++     HG ISR   + LL   G+DG YL+R+S+S PG Y L V  +G    YR+++ +
Sbjct: 69  LELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPGQYTLDVWKEGKSVHYRITKGD 128

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGR 108
            G +  +         F  +  LI   Q    G+ + L +   K+  +
Sbjct: 129 EGYFFRQG------VCFPTIPELIQHHQTRSDGLCSSLDHIAPKAHAK 170


>UniRef50_O14796 SH2 domain-containing protein 1B n=17 Tax=Theria RepID=SH21B_HUMAN
          Length = 132

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 47/105 (44%), Positives = 74/105 (70%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
            +  YHG+++++  E LLL  G+DG++LLRDSES+PGV CLCV ++  +YTYR+ + + G
Sbjct: 2   DLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHG 61

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
            +  +TA G  K+ F  +K LIS F+KP+QG+V  L  P++++S 
Sbjct: 62  YYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSP 106


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 53/104 (50%), Gaps = 7/104 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++A+  +HG I+R+  E LL     DG +L+R+S + PG Y LCV +Q  +  YRV   E
Sbjct: 679 LNAMPWFHGSITRDEAEHLLQPR-EDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 737

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
               + +      + +F  +  L++ ++    G+ T L   + K
Sbjct: 738 N-KLTIDD-----EEYFENLGQLVAHYEADADGLCTQLIKCLPK 775


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 31/117 (26%), Positives = 56/117 (47%), Gaps = 6/117 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           + +  +HGKISRE  E++L   G DG +++R+S S  G + L VL+Q  +  Y++ +   
Sbjct: 5   ENLCWFHGKISRERAEEILRQEGGDGVFMVRESASSEGDFVLSVLFQDEMVHYQIRRHGD 64

Query: 62  G-SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
              +S +    +H      +++LI  +++   G+VT LQ               G  
Sbjct: 65  DAFFSIDDHTPIH-----GLESLIEHYRESPNGLVTKLQAICRGKPPPHDVRSHGTE 116



 Score = 69.4 bits (169), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 19/122 (15%), Positives = 37/122 (30%), Gaps = 36/122 (29%)

Query: 6   VYHGKISRETGEKLLLAT-----------------------------GLDGSYLLRDSES 36
            YHG + R+    +L                                   G YL+R S  
Sbjct: 284 WYHGTLDRQIAVDILKEHAGKLMPGACSPSKEDKENDSTRSNDNETLDTSGVYLVRYSPK 343

Query: 37  VPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
             GV  L +L+      + + + +      +  P     +   +++LI  + +   G+  
Sbjct: 344 Q-GVDVLTLLFDNEARHFIIQR-KQNYLYIDDGP-----YMASLEHLIEHYSRFSDGLQI 396

Query: 97  PL 98
            L
Sbjct: 397 NL 398


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 9/115 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           +D    + GKI+RE  E+LL    + G +L+R+S + PG Y LCV+       +  YRV 
Sbjct: 27  LDLANWFFGKITREKAEELLTPREV-GLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 85

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            T     + +        FF  +  LI  +++   G+ T L+ P++K +    Q+
Sbjct: 86  STNDNRVTVD-----EDAFFPNLIELIKHYERDADGLCTMLKKPLKKKTEMVLQS 135


>UniRef50_UPI0000F2E785 PREDICTED: hypothetical protein n=1 Tax=Monodelphis domestica
           RepID=UPI0000F2E785
          Length = 197

 Score =  122 bits (308), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 95/105 (90%), Positives = 100/105 (95%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           MD+V+VYHG ISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ+E
Sbjct: 1   MDSVSVYHGNISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQSE 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
           TGSWSAETAPGV KR FRK+KNLISAFQKPDQGIV PLQ+PVEK 
Sbjct: 61  TGSWSAETAPGVQKRLFRKIKNLISAFQKPDQGIVIPLQHPVEKK 105


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  122 bits (307), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 26/126 (20%), Positives = 52/126 (41%), Gaps = 4/126 (3%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVS-Q 58
           +++   Y G++ R   E  L   G D GS+L+R SES    Y L V  +  +  YR+  +
Sbjct: 217 LESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVREENTVKHYRIRSR 276

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR-- 116
                 + +      +  F  ++ L++ + +   G+   L  P  + +   P   + +  
Sbjct: 277 YSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCIRPTHPEPVGLSHKLI 336

Query: 117 RDSDIC 122
              +I 
Sbjct: 337 DKWEIP 342


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score =  122 bits (307), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 30/117 (25%), Positives = 60/117 (51%), Gaps = 6/117 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           + ++ +HGK+SR+  EKL+     +G +L+R+S + PG + L +L+ G I  Y++ +  E
Sbjct: 5   ECISWFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGE 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
              +S +      +  F  ++ LI+  Q+ + G++T L    +K          G+ 
Sbjct: 65  DAFFSIDN-----EHIFHGLETLINYHQENENGLITKLTNFCKKDPPPHDTRCHGKT 116



 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 25/100 (25%), Positives = 48/100 (48%), Gaps = 7/100 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     YHG + R+   +LL   G  +GSYL+R S    GVY L ++     + +++ + 
Sbjct: 279 LSKYNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVNDRSFHFQI-KN 337

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
           E G +  +  P +       ++++I  + +   G+ T LQ
Sbjct: 338 ENGYYFIDDGPLLE-----SLEHVIDYYSRMQDGLPTVLQ 372


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score =  122 bits (306), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                +H K+SRE  E+ +++ G  +G +L+R+  +  G + L + Y  ++Y Y++ +  
Sbjct: 207 QDKPWFHHKLSREEAEQRIVSAGLQEGKFLVRER-TEEGSFALSLCYNNFVYHYKIDKDC 265

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
           TG  S +  P      F  +  ++  +Q    G++  L  P   ++      PT RR S
Sbjct: 266 TGQLSIKEGP-----KFDSLIQMVDHYQLKKDGLLCCLLVPCHDNNR---DTPTRRRHS 316



 Score =  109 bits (273), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 6/113 (5%)

Query: 7   YHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
           YHG+I+RE  E  L   G   G +LLR+S    G Y L + Y+  +Y Y + +   G+ +
Sbjct: 57  YHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYEDDVYHYAIERQYDGTVA 116

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            +       + F     L+S     + G++  L  P     G   +A +    
Sbjct: 117 IKDG-----KNFAGPIELVSNHMNREDGLLCRLLRPCNLQQGIAARAFSDMDH 164


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  122 bits (306), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 9/111 (8%)

Query: 2   DAVT--VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +      YHG I+RE  EK+L     DG++L+RDS + PG Y LC+ + G +  YR+ Q 
Sbjct: 40  EQHPKLWYHGNITREHTEKILSGQA-DGTFLVRDSTNFPGDYTLCMAFNGKVEHYRIYQL 98

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
             G  + +     H+  F  +  LI+ +++   G+   L  PV     R  
Sbjct: 99  -NGILTCD-----HEETFDNLTQLIAHYKRDADGLCHRLITPVISDDYRIT 143


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  121 bits (305), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 48/114 (42%), Gaps = 9/114 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     + GKI R   E++L     DG++L+R+SES PG + L V +   +  ++V +  
Sbjct: 55  MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDG 114

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
            G +            F  +  L+   +      V+  Q    +   + PQ PT
Sbjct: 115 AGKYFL------WVVKFNSLNELVDYHRSTS---VSRNQQIFLRDIEQVPQQPT 159


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  121 bits (304), Expect = 8e-27,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 48/111 (43%), Gaps = 11/111 (9%)

Query: 6   VYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVL-----YQGYIYTYRVSQT 59
             +  I+RE  E+LL+  +   GS+L+R+SE+  G Y L +       +  I  YR+ Q 
Sbjct: 89  WLYKGINREKAEELLMVNSNRSGSFLIRESETRSGSYTLSIRKTNHTSRDSIKHYRIHQL 148

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           + G +         +  F  +++++  + +   GI   L  P        P
Sbjct: 149 DNGWFYI-----APRLTFATLQDMVDYYSEVADGICCTLTEPCVVQRVPNP 194


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  121 bits (303), Expect = 9e-27,   Method: Composition-based stats.
 Identities = 25/103 (24%), Positives = 45/103 (43%), Gaps = 10/103 (9%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               +HG +S +  EKL+L  G +GS+L+R+S+S PG + L V     +    + + +  
Sbjct: 108 TERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMI-RWQDK 166

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYP 101
            +            F  +  LI  +++       G V  L+ P
Sbjct: 167 KYDVGGG-----ESFGTLSELIDHYKRNPMVETCGTVVHLRQP 204



 Score =  109 bits (274), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 25/107 (23%), Positives = 39/107 (36%), Gaps = 11/107 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPV 102
              +            F  +  L+  + +        G    L+ P+
Sbjct: 61  D-FFDLYGG-----EKFATLPELVQYYMENGELKEKNGQAIELKQPL 101


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  120 bits (302), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 22/122 (18%), Positives = 47/122 (38%), Gaps = 10/122 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           ++    Y G +SR+  E LL     +G +++R S +  G+Y L +     Q ++  Y + 
Sbjct: 405 LERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTK-GLYTLSLHTKVPQSHVKHYHIK 463

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ-YPVEKSSGRGPQAPTGR 116
           Q     +         K     + +LI+  +    G+   L+  P ++           +
Sbjct: 464 QNARCEYYLS-----EKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDK 518

Query: 117 RD 118
            +
Sbjct: 519 WE 520


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  120 bits (302), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 22/91 (24%), Positives = 39/91 (42%), Gaps = 6/91 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     + GKI R   E++L     DG++L+R+SES PG + L V +   +  ++V +  
Sbjct: 55  MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDG 114

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
            G +            F  +  L+   +   
Sbjct: 115 AGKYFL------WVVKFNSLNELVDYHRSTS 139


>UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=35 Tax=Euteleostomi
           RepID=Q64725-2
          Length = 606

 Score =  120 bits (302), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 32/136 (23%), Positives = 64/136 (47%), Gaps = 19/136 (13%)

Query: 2   DAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  +HG ISR+  E+ +L+ +  +G +L+R  ++  G + LC+L++G +  YR+ + +
Sbjct: 163 EKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNN-GSFALCLLHEGKVLHYRIDRDK 221

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK-----------SSGRG 109
           TG  S         + F  +  L+  +     G++  L  P +K           ++   
Sbjct: 222 TGKLSI-----PEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPV 276

Query: 110 PQAPTG-RRDSDICLN 124
           P  P G R +S +  N
Sbjct: 277 PPPPQGSRPESTVSFN 292



 Score =  103 bits (258), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 47/113 (41%), Gaps = 6/113 (5%)

Query: 6   VYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            + G I+RE  E  L+  G+ DG YLLR S +  G + L V +    + Y + +   G++
Sbjct: 14  YFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTY 73

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
           +         R      +L     +  +G+V  L+ P  +  G  P+      
Sbjct: 74  AISGG-----RAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKTGPFED 121


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  120 bits (301), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 25/100 (25%), Positives = 45/100 (45%), Gaps = 10/100 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HG +S +  E+L+L  G +GS+L+R+S+S PG + L V  +  +    +   E     
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRTEDKVTHVMIRWHENKY-- 115

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYP 101
                    + F  +  LI  +++       G V  L+ P
Sbjct: 116 ----DVGGGQKFGTLCELIEHYKRNPMVEICGTVVHLRQP 151


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  119 bits (300), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 26/132 (19%), Positives = 48/132 (36%), Gaps = 15/132 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGY--------I 51
           ++A   +   +SR+  E+LLL  G   G +L+R+SE+  G   L V  +          +
Sbjct: 174 VEAEEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTV 233

Query: 52  YTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV-EKSSGRGP 110
             YR+   +   +   T     K  F  ++ LI  +     G+   L             
Sbjct: 234 KHYRIKHPDYRYYYITT-----KCSFSSLQELIQFYSIDSHGLCCKLTRACLCPPPITSD 288

Query: 111 QAPTGRRDSDIC 122
            +   +   +I 
Sbjct: 289 LSVKTKDHWEIS 300


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  119 bits (300), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 22/103 (21%), Positives = 46/103 (44%), Gaps = 5/103 (4%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
               +H  ++R+    L    G +DG +L+R+S+ +PG + L   +   +  Y+++  E 
Sbjct: 657 TQPWFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSFSHNQKVKHYQINMVED 716

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
           G ++ +         F  +  L+  +Q    G+ T L +   K
Sbjct: 717 GVYTIDDGG----TRFTDLIQLVEFYQLNSGGLPTRLLHICTK 755


>UniRef50_UPI0000EAFFB4 SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2)
           (EAT-2). n=2 Tax=Canis lupus familiaris
           RepID=UPI0000EAFFB4
          Length = 134

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 51/115 (44%), Positives = 73/115 (63%), Gaps = 4/115 (3%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
            +  YHG +S++  E LLL  G+DG++LLRDSES+PGV CLCV ++  +YTYR+ +   G
Sbjct: 2   DLPYYHGPLSKKDCETLLLKDGIDGNFLLRDSESLPGVLCLCVSFKNLVYTYRIFEERRG 61

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
            ++ +T  G  K  F  +K LIS F+KP QG+V  L  P++K+S      P  RR
Sbjct: 62  FYNIQTVEGAPKEIFPNLKELISKFEKPSQGLVMHLIQPIKKAS----SCPRWRR 112


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)

Query: 5   TVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             Y+G I+R   EKLLL +   DGS+L+R SES    Y +    +G ++ +R+ ++  G+
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGA 308

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
           +         +  F  +  LIS +Q+ ++ +   L+ P  +     P     +R+
Sbjct: 309 YFVSD-----RISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLLCLQRE 358



 Score =  112 bits (280), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 45/114 (39%), Gaps = 6/114 (5%)

Query: 2   DAVTVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                + G ++R   +  LL     +G++L+R SE     Y L V     +  Y+V QT+
Sbjct: 65  QTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTD 124

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
              +  E       R F  +  L+  +QK       PL  P ++++   P    
Sbjct: 125 QNRFYVE-----PGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLP 173



 Score = 89.1 bits (220), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 22/95 (23%), Positives = 38/95 (40%), Gaps = 5/95 (5%)

Query: 20  LLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSAETAPGVHKRFFRK 79
           +     +G++L+R SE     Y L V     +  Y+V QT+   +  E       R F  
Sbjct: 729 VAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYVE-----PGRRFSS 783

Query: 80  VKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           +  L+  +QK       PL  P ++++   P    
Sbjct: 784 LAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLP 818


>UniRef50_UPI00016E9D38 UPI00016E9D38 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9D38
          Length = 130

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 66/121 (54%), Positives = 82/121 (67%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+ + VYHG I +E GE+ L   G DG YL+R+S+SVPGVYCLCVL  GY+YTYR+ Q  
Sbjct: 1   MENLPVYHGPIGKEEGERRLGQDGRDGCYLVRNSDSVPGVYCLCVLCHGYVYTYRLYQDH 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            GSW+A+T PGV KR FR ++NLI+AFQKP QGIV PL YPV        Q  T    + 
Sbjct: 61  GGSWAADTTPGVPKRSFRHIRNLIAAFQKPGQGIVMPLLYPVTAQIRARTQMKTQMSSNS 120

Query: 121 I 121
           +
Sbjct: 121 L 121


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 28/110 (25%), Positives = 47/110 (42%), Gaps = 11/110 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY----QGYIYTYRV 56
           +     +HG I R   E LL  +   G++L+R+SE++ G Y L ++        I  +R+
Sbjct: 63  LTNEPWFHGNIGRIEAENLLQYS-EPGTFLIRESETIKGSYTLTMIQIKDGTKQISHFRI 121

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
           +    G +          R F  +  LI  + +   G+   L YP  K S
Sbjct: 122 NYD-DGKYFI-----TSARRFLGLHQLIQHYMQNSDGLACNLVYPQPKPS 165


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 29/129 (22%), Positives = 52/129 (40%), Gaps = 13/129 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY------QGYIYTY 54
           +D    + G ISR   E+LL   G +G++++R+S S  G+Y + +        +G +  Y
Sbjct: 291 LDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHY 349

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE-KSSGRGPQAP 113
            V                    F  +  LI   Q    G++T L++PV  K++       
Sbjct: 350 HVHTNAENKLYL-----AENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVS 404

Query: 114 TGRRDSDIC 122
            G    ++ 
Sbjct: 405 LGNGIWELK 413


>UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS
          Length = 938

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 3/115 (2%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-E 60
           D +  +H  +SRE  + LL     DG++L+R+S +  G + L +L Q  +  Y+V +  E
Sbjct: 5   DHMKWFHANLSREAADDLLRQGYEDGTFLVRESSTAAGDFVLSILCQEEVCHYQVRRHGE 64

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
              +S +       +    ++ L+  +Q+   G+ T L  P+ +          G
Sbjct: 65  DAFFSIDDEMQT--KILHGLETLVDYYQQGANGLPTKLTVPLIRDPPPHNTRRHG 117



 Score = 73.3 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 24/121 (19%), Positives = 43/121 (35%), Gaps = 29/121 (23%)

Query: 4   VTVYHGKISRETGEKLLLATGLD-----------GSYLLRDSES-VPGVYCLCVLYQGYI 51
              YHG  +R+     L     +           G +L+R SES       L +L    +
Sbjct: 284 EQWYHGTQTRDEAVATLTQYAKELLAKQPGVDTSGCFLVRYSESPAASGLVLTLLSDQVV 343

Query: 52  YTYRVSQ------------TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
             +R+SQ             E      +  P     ++  +++LI+ F +   G+   L+
Sbjct: 344 KNFRISQAYLYTNGVKVQSDEQKFVFIDDGP-----YWPSLEHLIANFMRFSYGLPVSLK 398

Query: 100 Y 100
           Y
Sbjct: 399 Y 399


>UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4774
          Length = 132

 Score =  118 bits (297), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 40/101 (39%), Positives = 65/101 (64%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           YHG I R+T E+LL     DG+YL+RDSE+VPG  CLCV     +YTYR+ +T +G +  
Sbjct: 5   YHGAIGRKTCEELLGKKNKDGAYLIRDSETVPGAMCLCVFKGRVVYTYRLLKTRSGDYML 64

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
             A G+ + +F+ +++LI  +++ DQG+   L++ V++   
Sbjct: 65  MVADGIEETYFKNLEDLIRHYKRRDQGLAMHLRHAVQRKIA 105


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  118 bits (297), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 23/123 (18%), Positives = 48/123 (39%), Gaps = 8/123 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   + GK++R      L++   + GS+L+R SES    Y L V  +     +++ QT
Sbjct: 129 VESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQT 188

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
               +  +         F  +  +I  +Q     I   L  P  +        P+   + 
Sbjct: 189 GD-QFYVDALF-----KFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVPPPST-DEW 241

Query: 120 DIC 122
           ++ 
Sbjct: 242 ELP 244


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  118 bits (296), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 33/131 (25%), Positives = 53/131 (40%), Gaps = 13/131 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY------QGYIYTY 54
           ++    Y   ++R   E+LL   G +G +++RDS S  G Y + V        QG I  Y
Sbjct: 276 IEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHY 334

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
            V  T    +         K  F  +  LI+  Q    G+++ L+YPV + +   P    
Sbjct: 335 VVCSTPQSQYYL-----AEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAG 389

Query: 115 -GRRDSDICLN 124
            G    +I   
Sbjct: 390 LGYGSWEIDPK 400


>UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostomi RepID=KSYK_HUMAN
          Length = 635

 Score =  117 bits (294), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 32/116 (27%), Positives = 59/116 (50%), Gaps = 7/116 (6%)

Query: 2   DAVTVYHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  +HGKISRE  E++ L+ +  +G +L+R  ++  G Y LC+L++G +  YR+ + +
Sbjct: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
           TG  S         + F  +  L+  +     G++  L  P +K   +G     GR
Sbjct: 223 TGKLSI-----PEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273



 Score =  106 bits (266), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 27/114 (23%), Positives = 45/114 (39%), Gaps = 6/114 (5%)

Query: 5   TVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             + G I+RE  E  L+  G  DG YLLR S +  G + L V +    + Y + +   G+
Sbjct: 14  PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
           ++         R      +L     +   G+V  L+ P  +  G  P+      
Sbjct: 74  YAIAGG-----RTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFED 122


>UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine kinase n=3
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48523
          Length = 837

 Score =  117 bits (294), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 28/125 (22%), Positives = 53/125 (42%), Gaps = 7/125 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     +HG + R+   + +   G  DG +LLR S + P    L +   G ++ + ++ T
Sbjct: 346 LQGKPWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEIN-T 404

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
           +  S+  +  P     +F  ++ LI  + + D G+ T L +P+    GR    P  R   
Sbjct: 405 KMESFYIDDGP-----YFDTLEQLIDHYSRYDDGLPTMLLHPIPPPPGRIDNGPPTREKP 459

Query: 120 DICLN 124
                
Sbjct: 460 SPAPR 464



 Score =  111 bits (277), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 51/115 (44%), Gaps = 14/115 (12%)

Query: 6   VYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            +HG+I+R+T   +L   G  +G++L+R+S S  G Y + +++ G    +++       +
Sbjct: 76  WFHGRITRDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSIMHNGLPQHFQIQCMGDFYY 135

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY--------PVEKSSGRGPQ 111
             +  P      F+ +  LI+ ++    G+ T L          P  +  GR   
Sbjct: 136 KIDNGPL-----FQGLDQLINYYRMGSNGLPTKLTVFCNGRIPPPCSRRFGRTTP 185


>UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound protein 14 isoform 1 n=1
           Tax=Pan troglodytes RepID=UPI0000E1F79D
          Length = 491

 Score =  117 bits (293), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 25/104 (24%), Positives = 49/104 (47%), Gaps = 2/104 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            +   +H KISR+  ++L++  G +DG +L+RDS+S P  + L + +   I  +++   E
Sbjct: 386 RSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVE 445

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
                  T    H R F  +  L+  +Q     +   L++   +
Sbjct: 446 DDGEMFHTLDDGHTR-FTDLIQLVEFYQLNKGVLPCKLKHYCAR 488


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  116 bits (292), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 29/129 (22%), Positives = 52/129 (40%), Gaps = 12/129 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           +++   +   + R+  +KLLL      G++L+R SE  P  Y L V         ++  Y
Sbjct: 157 VNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHY 216

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ-AP 113
           R+   + G +   T      + F  ++ L+ A+ K   G+   L  P  K   +     P
Sbjct: 217 RIKPLDNGGYYIAT-----NQTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMWDLGP 271

Query: 114 TGRRDSDIC 122
             R   +I 
Sbjct: 272 ELRDKYEIP 280


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score =  116 bits (292), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 10/123 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATG---LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           DA   YHGKI+RE    L+        +G +L+R+S   PG Y L +  +G +  +++  
Sbjct: 6   DAERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQIMG 65

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
              G +S +  P      F+ +  LI  +Q    G+   L   V       P     R +
Sbjct: 66  HGEGWFSVDNGPL-----FQGLDELIHHYQLKPDGLPVQLNDYVI--GNPPPPGARKRTE 118

Query: 119 SDI 121
           +++
Sbjct: 119 TEL 121



 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 28/124 (22%), Positives = 47/124 (37%), Gaps = 6/124 (4%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           M+     H  I R    + L   G  DGS+L+R +   PG Y L ++Y+   Y Y V   
Sbjct: 287 MNTNDFLHKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTPYHYEVVCE 346

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
               +  +  P      F  +  ++  +     G+ T L YPV  S  +     +  +  
Sbjct: 347 SDCWYFIDDGPL-----FDTLPAVVDHYTIFADGLPTTLLYPVPPSGRKNVPFSSPPQPG 401

Query: 120 DICL 123
            +  
Sbjct: 402 ALLF 405


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score =  116 bits (291), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 21/140 (15%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  YHG ++R   E LLL+ G DGSYLLRDS    G+Y L V  +  +  + V  T 
Sbjct: 30  LQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTG 89

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKSSGRG------ 109
                   +       F  +K+ +  F          G +  L++P  +           
Sbjct: 90  -------YSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESV 142

Query: 110 ---PQAPTGRRDSDICLNAP 126
                  TGR + D+   AP
Sbjct: 143 RVHTAMQTGRTEDDLVPTAP 162


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score =  116 bits (291), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 33/130 (25%), Positives = 56/130 (43%), Gaps = 15/130 (11%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---------QGYIYTYRV 56
            Y   ++R   ++LL+  G +G++++RDS S  GVY + V              +  Y++
Sbjct: 213 WYSKNMNRMQAQELLMREGKEGAFMVRDS-SHMGVYTVSVFTKAPSQSGEKNPKVKHYQI 271

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS--SGRGPQAPT 114
            QTETG   A          F  +  LI   Q    G++T L++PV     S +   AP 
Sbjct: 272 RQTETG---AGPFYLAENYLFNTIPELIHYHQHNAAGLITRLRHPVSPDGSSAQQVSAPF 328

Query: 115 GRRDSDICLN 124
                ++  +
Sbjct: 329 EADQWELNPD 338


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  116 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 13/126 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLY---QGYIYTYRVS 57
           ++    +   I+R   E+LL   G +GS+L+R+S S  G   + V        +  Y V 
Sbjct: 256 LEQNRWFCKDITRAKAEQLLRQAGSEGSFLVRES-SQVGKLTVSVYSCIPCEVVKHYHVK 314

Query: 58  QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA---PT 114
           Q  TG W         K  F  + +LI   Q    G+VT L++PV +     P       
Sbjct: 315 QLPTGEWYL-----AEKHTFSTISDLIHYHQHNAAGLVTRLRHPV-RPGEELPSTAGLSY 368

Query: 115 GRRDSD 120
           G+ + D
Sbjct: 369 GKWELD 374


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  115 bits (289), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 24/130 (18%), Positives = 55/130 (42%), Gaps = 12/130 (9%)

Query: 1   MDAVTVYHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLY------QGYIYT 53
           +++   Y GKI R   E+L L +    G++L+R+ E+    + L +         G +  
Sbjct: 133 IESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKH 192

Query: 54  YRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK-SSGRGPQA 112
           Y++ + +             +R FR ++ L+  +     G+   L +P  + +  R   +
Sbjct: 193 YKIKRLDHDQGYF----ITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLS 248

Query: 113 PTGRRDSDIC 122
              +++ +I 
Sbjct: 249 HDTQQNWEIP 258


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score =  115 bits (289), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 27/106 (25%), Positives = 41/106 (38%), Gaps = 8/106 (7%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++  T YHG I+R   E LL +   +GSYL+R+SES    Y L +         R+    
Sbjct: 1089 LEKQTWYHGSITRVEAEDLLRSL-KEGSYLVRNSESAKQDYSLSLKSAKGFMHMRIQIDN 1147

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
                      G   + F  + ++I  +      I       L  PV
Sbjct: 1148 NSGQFI---LGQFSKPFNSIPDMIRHYSVNKLPIRGAEHMCLLKPV 1190


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score =  114 bits (287), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 21/106 (19%), Positives = 44/106 (41%), Gaps = 8/106 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
                +H  I+RE    ++   G +DG YL+R+S++ PG + L   +   +  Y++    
Sbjct: 628 QTQPWFHHGINREEANNMMHMQGMVDGLYLVRESQTFPGTFVLTFCHDQRVKHYQIQPNV 687

Query: 59  -TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
             +   +S +      +  F  +  L+  +Q     +   L +P  
Sbjct: 688 IDDKTFYSLDEG----ETKFGDLVQLVEFYQINRGALPHSLTHPCT 729


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score =  114 bits (287), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 29/127 (22%), Positives = 51/127 (40%), Gaps = 12/127 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  YHG +SR   E LL+A   DGSYLLR S +  G Y L V  +  +  +++    
Sbjct: 9   VEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSVKHFQIGWDG 68

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKSSGRGPQAPTG 115
                           F+ ++  +  F          GI+T L++P  ++        T 
Sbjct: 69  -------KQYQFGMGVFQSLQEFVEHFANQPLIGGESGILTALRHPYSRNVLEPDVYDTV 121

Query: 116 RRDSDIC 122
              + + 
Sbjct: 122 TVHASLG 128


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score =  114 bits (286), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 23/109 (21%), Positives = 49/109 (44%), Gaps = 7/109 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  YH  ++R+  ++++  T  DG++L+R+  S P +Y L   +QG +  Y +    
Sbjct: 542 VEKLLWYHADMTRQEADQVMQNTN-DGTFLVRN-ASKPKMYTLSFSFQGVVKHYHIKTDS 599

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
              +         +  F  V  LI   +    G+ T L++P   ++   
Sbjct: 600 DNLFYVS-----QRHSFESVVQLIEYHKLNSAGLATRLRFPYTGTNNPP 643


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  114 bits (286), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 31/113 (27%), Positives = 46/113 (40%), Gaps = 12/113 (10%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
                YHG +SR   E LL     DG YL+R+SES PG + L +     I  +++     
Sbjct: 276 RDKDWYHGTLSRSECEFLLNEHAKDGEYLIRNSESKPGDFSLSMKAPNRIKHFKILY-GN 334

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKSSGRG 109
             +         +R F  +  L+S ++         G    L YP+ KS  R 
Sbjct: 335 NQYVI------GQRSFSNIDELLSHYKNYPIYTTENGQKMHLLYPLNKSFTRN 381


>UniRef50_O15357 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 n=31
           Tax=Euteleostomi RepID=SHIP2_HUMAN
          Length = 1258

 Score =  114 bits (286), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 2/119 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
            A + YH  +SR   E+LL   G DGS+L+RDSESV G + LCVLYQ +++TYR+     
Sbjct: 17  QAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGE 76

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
              + +T+ GV  R F+ +  LI  + +P+QG+V  L  PV     R P  P  R  SD
Sbjct: 77  DFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPV--EGEREPDPPDDRDASD 133


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score =  114 bits (285), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 58/125 (46%), Gaps = 8/125 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           D     HGKISRE  + L+ + G  +G +L+R+S   PG Y L V+ QG +  +++S+ +
Sbjct: 26  DKPPYMHGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALSVVAQGKLQHFKISR-K 84

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           TG +  +  PG     F  +  L+  ++ PD  + T L      +     +    +   +
Sbjct: 85  TGLYRIDDGPG-----FGSLDELVQFYRNPDDRLPTVLVRFCASTVSAS-ELQQYQNHWN 138

Query: 121 ICLNA 125
             L  
Sbjct: 139 ASLPT 143


>UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_HUMAN
          Length = 276

 Score =  114 bits (285), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 22/108 (20%), Positives = 46/108 (42%), Gaps = 7/108 (6%)

Query: 4   VTVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
                  + R+  E+LL       GS+++R+SE+  G Y L V ++  +  YR+ +    
Sbjct: 82  HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFRLPNN 140

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
            +         +  F+ +++L++ + +   G+   L  P    S   P
Sbjct: 141 WYYIS-----PRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAP 183


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  113 bits (284), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 27/133 (20%), Positives = 50/133 (37%), Gaps = 16/133 (12%)

Query: 1   MDAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVL-----YQGYIYTY 54
           ++    +   I+R+  E +LL      G++L+R+SE++ G Y L V      +   I  Y
Sbjct: 172 LETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDVIKHY 231

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA-- 112
           ++   + G +         +  F  + ++I  +Q               +S    P    
Sbjct: 232 KIRSLDNGGYYIS-----PRITFPCISDMIKYYQTNYMKTWVVAAEIAPRSPHLAPATTS 286

Query: 113 ---PTGRRDSDIC 122
              P G   SD C
Sbjct: 287 RLSPEGSCWSDFC 299


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score =  113 bits (283), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 26/104 (25%), Positives = 47/104 (45%), Gaps = 4/104 (3%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-T 59
                +HG+I RE   K+++  G +DG +LLRDS+S P  + L + +   I  +++    
Sbjct: 503 RTQVWFHGRIVREEAHKMIIQQGQVDGLFLLRDSQSNPRAFVLTLCHHQKIKHFQILPCE 562

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
           E G        G     F  + +L+  +Q     +   L++P  
Sbjct: 563 EDGQVFFSLDDG--STKFTDLIHLVDFYQLNRGVLPCKLKHPCT 604


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  112 bits (282), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 44/115 (38%), Gaps = 19/115 (16%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG----------YIY 52
           +   +HG +S    EKLL   G +GS+L+R+S+S PG + L V               + 
Sbjct: 109 SERWFHGHLSGREAEKLLTEKGKNGSFLVRESQSHPGDFVLSVRTGDDKTDSSDSKPKVT 168

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYPVE 103
              +       +            F  + +L+  ++K       G V  L+ P+ 
Sbjct: 169 HVMIRCQHDLKYDVGGG-----EKFDSLTDLVEHYKKNPMVETLGTVLQLKQPLN 218



 Score =  109 bits (274), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 12/109 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  I+    E LLL  G+DGS+L R S+S PG + L V   G +   ++  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP------DQGIVTPLQYPVE 103
              +            F  +  L+  + +         G V  L+YP+ 
Sbjct: 61  D-YYDLYGG-----EKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  112 bits (282), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 30/113 (26%), Positives = 49/113 (43%), Gaps = 9/113 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVL-----YQGYIYTY 54
           ++    + G  +R      L A  L  G++L+R+SE+ PG Y L V      +   I  Y
Sbjct: 108 LEVEGWFFGSCTRSEAIMRLQADNLPKGTFLVRESETRPGTYALTVRETDHGHPPTIKNY 167

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSG 107
           RV +T+ GS   E      +R F  V +++        G+ + L  P  K + 
Sbjct: 168 RVDKTKDGS---ELFFINPQRKFNTVIDVVKFHTSQPGGLCSKLLKPCPKQTP 217


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score =  112 bits (281), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 26/126 (20%), Positives = 49/126 (38%), Gaps = 14/126 (11%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSE--SVPGV--YCLCVLYQGYIYTYRVSQTE 60
             +H  +SR   E++L    +DG++L+R SE  +  G   Y +    +G +   R+   E
Sbjct: 654 AWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQNTKAGQKNYAISFRAEGKVKHCRIEVDE 713

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
           +G +   +A       F  +  L+  ++         L+Y +            G  +SD
Sbjct: 714 SGQYCIGSA------IFDSLTELVQYYEANPLYRRMRLKYAI----NEDLLKSLGEAESD 763

Query: 121 ICLNAP 126
                P
Sbjct: 764 DVYYHP 769



 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 25/112 (22%), Positives = 44/112 (39%), Gaps = 8/112 (7%)

Query: 3   AVTVYHGKI--SRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
               +HGK+   R   EKLL     ++G++L+R+S +  G Y L  +  G     R+   
Sbjct: 541 KEKWFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTTFTGDYSLSFVRDGKYNHCRIHTK 600

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT---PLQYPVEKSSGR 108
             G  +      + +  F  +  LI  ++       T    L  PV + +  
Sbjct: 601 SEGGKT--RFYLIDQTLFDSIYELIMHYKSNPLKSPTFEQVLAEPVPQQNSH 650


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score =  112 bits (281), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 28/135 (20%), Positives = 54/135 (40%), Gaps = 13/135 (9%)

Query: 3   AVTVYHGKISRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           A   YHG++ R+  ++LL    G DGS+++R+S +  G   L  +Y G +   R+   + 
Sbjct: 565 AEKWYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCTLSFMYHGRVTHCRIHSQQN 624

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKSSGRGP-----Q 111
              +      VH   F  + +L+  +Q+             L  PV + +          
Sbjct: 625 NGHT--YFYLVHALLFDSLYSLVWHYQRYPLRNAKMNFELLLTEPVPQPNAHANKEWYHD 682

Query: 112 APTGRRDSDICLNAP 126
           + T     ++ +  P
Sbjct: 683 SMTRTDAENVLMRIP 697



 Score = 96.0 bits (238), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 21/106 (19%), Positives = 39/106 (36%), Gaps = 10/106 (9%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSES---VPGVYCLCVLYQGYIYTYRVSQT 59
               YH  ++R   E +L+    DG++L+R   S       + +     G I   R+ Q 
Sbjct: 676 NKEWYHDSMTRTDAENVLMRIPRDGAFLVRKCRSDDPSVTSFAISFRADGKIKHCRIKQE 735

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                       +    F  + ++IS ++K        L++P  K 
Sbjct: 736 SR-------LFVIGNATFETLCDVISFYEKNPLYRKMKLKHPATKE 774


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  112 bits (280), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 33/126 (26%), Positives = 52/126 (41%), Gaps = 7/126 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     Y   +SR   ++LLL+   + G++L+R SES  G Y L V  Q  +  YRVS  
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMA 174

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
             GS   +       R F  ++ L++ ++   + I  PL  P              R  S
Sbjct: 175 ADGSLYLQKG-----RLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDV-WERPHS 228

Query: 120 DICLNA 125
           +  L  
Sbjct: 229 EFALGR 234


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score =  112 bits (280), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 40/103 (38%), Gaps = 9/103 (8%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               +HGKI+ +  EK+LL  G    +L+R+S   PG Y L VL    +    +     G
Sbjct: 111 TERWFHGKITGKEAEKMLLERGKPDCFLVRESVHRPGSYVLSVLTGEQVAHIMIHGKPNG 170

Query: 63  SWSAETAPGVHKRFFRKVKNLISAF----QKPDQGIVTPLQYP 101
            +            F  +K LI  +         G +  L+ P
Sbjct: 171 MYDVGGG-----HQFSSLKELIDFYTNTPMVEKNGGLVSLKQP 208



 Score =  101 bits (251), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 26/117 (22%), Positives = 44/117 (37%), Gaps = 12/117 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  ++    EKLL   G+ GS+L R S S PG + L V     +   R+  TE     
Sbjct: 8   WFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGDEVTHIRIQNTEE---- 63

Query: 66  AETAPGVHKRFFRKVKNLISAFQKP------DQGIVTPLQYPVEKSSGRGPQAPTGR 116
                      F  +  L++ + +         G +  L+YP+        +   G+
Sbjct: 64  --FLDLYGGEKFATLSELVTYYMENEGQLREKNGDLIELKYPLISEDPTTERWFHGK 118


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score =  111 bits (279), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 30/109 (27%), Positives = 43/109 (39%), Gaps = 8/109 (7%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            +D    YHG ISR   EK+L   G +GS+L+R+SES    Y L +         R+ +  
Sbjct: 975  LDRQGWYHGSISRIDAEKILRPLG-EGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDP 1033

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
              S       G   R F  + ++I  F      +       L  PV   
Sbjct: 1034 DSSQYI---LGQFSRPFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQ 1079


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  111 bits (278), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 9/116 (7%)

Query: 6   VYHGKISRETGEKLLLAT--GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT-ETG 62
            YHGKISR+T E +LL      DG +L+R+S S  G Y LCVL    +  Y++ +  E  
Sbjct: 12  WYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQNNEVVHYQIRRHGEDA 71

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQG-IVTPLQYPVEKSSGRGPQAPTGRR 117
            +S +    +H      ++ LI  + K +   +   L  P+ K          GR 
Sbjct: 72  FFSIDEQNIMH-----GLETLIEHYCKVNDPSLGVQLSKPIVKDPPPHDTRRHGRT 122



 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 24/110 (21%), Positives = 44/110 (40%), Gaps = 10/110 (9%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHGK+ R     +L    +DG +L+R   +    Y L ++     Y +++ Q     + 
Sbjct: 290 WYHGKLDRHEATAILKTKDVDGCFLVRM--NRQSGYVLSMMCTNQCYHFQI-QDRDKYYF 346

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
            +  P     +   +++LI  +     G+   L+ PV       P  P G
Sbjct: 347 IDNGP-----YLNSLEHLIQHYTLFPDGLPNKLEVPVS--PAVIPPLPKG 389


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score =  111 bits (278), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 28/133 (21%), Positives = 50/133 (37%), Gaps = 15/133 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQ------GYIYTY 54
           +D    Y   ++R   E+LL +   +G +++RDS S PG+Y + +  +           Y
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHY 300

Query: 55  RVS--QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
            +    T    +         K  F  +  +I   +    G+VT L+YPV       P  
Sbjct: 301 HIKETTTSPKKYYL-----AEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355

Query: 113 PTGR-RDSDICLN 124
                   +I  +
Sbjct: 356 AGFSYEKWEINPS 368


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score =  111 bits (278), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 48/114 (42%), Gaps = 9/114 (7%)

Query: 3   AVTVYHGKIS--RETGEKLLLA--TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +   +HGK+   R   E LL       DG++L+R+SE+  G Y L    QG +   R+  
Sbjct: 592 SEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRESETFVGDYSLSFWRQGKVNHCRIRS 651

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKSSGRG 109
            +    +      +    F  + +LI+ ++      Q  +  L+ PV + +   
Sbjct: 652 KQDKGQT--KYYLIDTNSFDSLYSLITYYRSHPLRSQEFLIVLKEPVPQPNKHE 703



 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 19/104 (18%), Positives = 40/104 (38%), Gaps = 7/104 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    Y   ++R   E++L     DG++L+R SE     Y +    +  I   R+     
Sbjct: 703 EGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRPSERGANSYAISFRAEKKIKHCRIKVDGR 762

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                     +   +F  + +LI+ +++        L +PV + 
Sbjct: 763 -------LYAIGSVYFESLVDLITYYERHPLYKKIRLCHPVNEE 799


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score =  111 bits (277), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 6/105 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     Y G + R +    LL+ G  GS+L+R S S PG Y L +  +  +  Y + +T+
Sbjct: 95  LKKYDWYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGDYTLSLHNETSLKHYHIKKTK 154

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
             ++         K  F  + +L+  ++K   G+   L+    + 
Sbjct: 155 NCTFYIL------KEEFSNLPSLVEHYKKVSGGLPRTLKDACSQK 193


>UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepID=HTK16_HYDAT
          Length = 757

 Score =  111 bits (277), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 6/122 (4%)

Query: 6   VYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             H  + R     +L    + DGS+L+R S    G Y L ++Y+   Y +++       +
Sbjct: 287 WLHQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKTYHFQIKSRADRWF 346

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICLN 124
             +  P      F  + +L+  + +   G+ T LQ+PV  +  R    P     + + L 
Sbjct: 347 YIDDGPL-----FETLPHLVDHYMQYADGLPTLLQFPVPSAENRKRPLPPTPTKNQLKLP 401

Query: 125 AP 126
            P
Sbjct: 402 VP 403



 Score =  109 bits (274), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 28/113 (24%), Positives = 48/113 (42%), Gaps = 6/113 (5%)

Query: 6   VYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            YHGKI+RE   + LL   G DG +L+RD  + P  Y L ++++  I  ++++      +
Sbjct: 10  WYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRSQILHFQINCLGDNKF 69

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
           S +  P      F+ +  LIS ++    G+   L                G  
Sbjct: 70  SIDNGP-----IFQGLDMLISYYKVISDGLPCKLVDFCVGKIAPLYALKYGLD 117


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score =  111 bits (277), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 28/131 (21%), Positives = 44/131 (33%), Gaps = 11/131 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGRGPQAPTG 115
              +            F  +  L+  + +        G    L+ P+  +     +    
Sbjct: 61  D-FFDLYGG-----EKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERGHYK 114

Query: 116 RRDSDICLNAP 126
               DI    P
Sbjct: 115 EATLDIPTAIP 125


>UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q3ZB94_DANRE
          Length = 271

 Score =  111 bits (277), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 24/113 (21%), Positives = 48/113 (42%), Gaps = 7/113 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
                  +SR+  E+LL   G   GS+L+R+S    G+Y L V ++  +  Y++ +    
Sbjct: 82  HGWLFEGVSRQKAEELLSLPGNSAGSFLIRESPRERGLYSLSVRHR-SVKHYKIFRLTNS 140

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTG 115
            +         +  F+ ++++++ +     GI   L  P    S   P +  G
Sbjct: 141 WYYIS-----PRLTFQCLEDMVNHYSDSSDGICCVLSAPCLALSNPTPSSIQG 188


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score =  110 bits (276), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 41/109 (37%), Gaps = 8/109 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +D    YHG ISR   EK+L     +GS+L+R+SES    Y L +         R+ +  
Sbjct: 731 LDRQGWYHGSISRIDAEKILRPL-SEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDA 789

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
                     G   R F  + ++I  F      +       L  PV   
Sbjct: 790 DSGQFI---LGQFSRPFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQ 835


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 36/109 (33%), Gaps = 14/109 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHG I R   ++LL      G +L+R+S   PG Y L V   G    + +    
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKKQ---GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQ--- 508

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI----VTPLQYPVEKS 105
                 +         F  +  LI       Q I       L  P+ K 
Sbjct: 509 ----YVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKD 553


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 31/125 (24%), Positives = 51/125 (40%), Gaps = 7/125 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +  +  +HGKIS +   + L     DG +L+R+S   PG Y LCV +   +  YRV    
Sbjct: 117 LSLMPWFHGKISGQEAVQQLQP-PEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL-HR 174

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G  + +        FF  + +++  + K    I T L  P  K   +  +    R    
Sbjct: 175 DGHLTID-----EAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWL 229

Query: 121 ICLNA 125
           + L  
Sbjct: 230 LNLQH 234


>UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E4312
          Length = 350

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 23/104 (22%), Positives = 46/104 (44%), Gaps = 8/104 (7%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +   +HG +SR+  ++L+   G +DG +L+R+S+     + L + +Q  I  Y V   E 
Sbjct: 246 SQPWFHGGVSRKEAQRLIEKQGLVDGMFLIRESQQHGQCFVLSLSHQLKIKHYLVIPCED 305

Query: 62  G---SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           G    ++ +         F  +  L+   Q     +   L++P 
Sbjct: 306 GGRKYFTIDDGL----TLFIDLLQLVEFHQINKGILPVCLKHPC 345


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 12/109 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   +H  I+    E LLL  G+DGS+L R S+S PG + L V   G +   ++  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP------DQGIVTPLQYPVE 103
              +            F  +  L+  + +         G V  L+YP+ 
Sbjct: 61  D-YYDLYGG-----EKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103



 Score =  109 bits (274), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 46/115 (40%), Gaps = 20/115 (17%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQG----------YIY 52
           +   +HG +S +  EKLL   G  GS+L+R+S+S PG + L V               + 
Sbjct: 109 SERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVT 168

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQ----GIVTPLQYPVE 103
              + + +   +            F  + +L+  ++K       G V  L+ P+ 
Sbjct: 169 HVMI-RCQELKYDVGGG-----ERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLN 217


>UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=Euteleostomi
           RepID=Q5SUW3_MOUSE
          Length = 550

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 46/104 (44%), Gaps = 2/104 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                +HG+ISRE   +++   G +DG +LLRDS+S P  + L + +   I  +++   E
Sbjct: 445 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 504

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
               +  T        F  +  L+  +Q     +   L++   +
Sbjct: 505 DDGQTFFTLDD-GNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 547


>UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2_HUMAN
          Length = 261

 Score =  109 bits (274), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 25/118 (21%), Positives = 44/118 (37%), Gaps = 11/118 (9%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDG-SYLLRDSESVPGVYCLCVLYQ-----GYIYTYRV 56
           +    +  +SRE  E+LLL  G  G ++L+R+S++  G Y L V          I  YR+
Sbjct: 91  SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
              + G           +  F  ++ L+  + +    I   L+ P             
Sbjct: 151 HCLDNGWLYIS-----PRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKD 203


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score =  109 bits (274), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 25/122 (20%), Positives = 49/122 (40%), Gaps = 10/122 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVP--GVYCLCVLYQGYIYTYRVSQT 59
            +   Y GKISR+  E+ L++   DG++++RDSES P  G + L V ++  +  +++   
Sbjct: 58  KSHPWYVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKILTD 117

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKP--DQGIVTPLQYPVEKSSGRGPQAPTGRR 117
             G +            F  + +L+   +     +     L  P         +     +
Sbjct: 118 LAGKYFL------WVVKFTSINDLVDYHKDNSVSRTQEIVLNEPCVPIEDANQRPQPAMQ 171

Query: 118 DS 119
            S
Sbjct: 172 QS 173


>UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 n=1 Tax=Monodelphis
           domestica RepID=UPI0000F2B3BE
          Length = 310

 Score =  109 bits (273), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 23/106 (21%), Positives = 46/106 (43%), Gaps = 11/106 (10%)

Query: 3   AVTVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVL-----YQGYIYTYRV 56
           +    +  ++RE  E LLL  +   GS+L+R+S++  G Y L V       +  +  YR+
Sbjct: 131 SQGWLYEGLNREKAEDLLLLPSNHGGSFLIRESQTRRGAYSLSVRLSRPTSRDVVRHYRI 190

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
            + E G +         +  F  ++ L+  + +    + + L  P 
Sbjct: 191 HRLENGWFYIS-----PRLTFPSLQALVEHYTEMADDLCSLLVEPC 231


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  109 bits (272), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 21/89 (23%), Positives = 44/89 (49%), Gaps = 6/89 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     Y G+ISR+  E++L+     G++L+R+SES PG + + V Y   +  ++V +  
Sbjct: 55  VKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREA 114

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK 89
           +G +         +  F  +  L+  ++ 
Sbjct: 115 SGKYFL------WEEKFNSLNELVDFYRT 137


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score =  109 bits (272), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 24/109 (22%), Positives = 39/109 (35%), Gaps = 8/109 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    +HG I+R   E +L     +GS+L+R+SES    Y L +         R+ +  
Sbjct: 792 LEKQGWFHGAITRVEAENVLR-MLREGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDG 850

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
                     G   + F  +  +I  F      I       L  PV   
Sbjct: 851 NDECYI---LGQFSKPFHSIPEMIRHFCINRLPIRGAEHMCLLQPVIAQ 896


>UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleostomi
           RepID=ZAP70_HUMAN
          Length = 619

 Score =  109 bits (272), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 24/109 (22%), Positives = 45/109 (41%), Gaps = 6/109 (5%)

Query: 5   TVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             ++G ISR   E+ L   G+ DG +LLR      G Y L +++    + + + +   G+
Sbjct: 9   PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 68

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQA 112
           ++         +       L   + +   G+   L+ P  + SG  PQ 
Sbjct: 69  YAIAGG-----KAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQP 112



 Score =  102 bits (255), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 7/103 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +  YH  ++RE  E+ L +    DG +LLR  +   G Y L ++Y   +Y Y +SQ +
Sbjct: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
            G +            F  +  L+   +    G++  L+    
Sbjct: 218 AGKYCI-----PEGTKFDTLWQLVEYLKLKADGLIYCLKEACP 255


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  109 bits (272), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 33/130 (25%), Positives = 48/130 (36%), Gaps = 16/130 (12%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             YHG + R++ E  L A    GSYL+R+SE  PG Y L  L Q  I  +RV+      +
Sbjct: 67  EWYHGCLDRQSAELRLNAADKPGSYLVRESERKPGSYVLSYLGQRGINHFRVTAVCGDFY 126

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIV-TPLQYPVEKSSGRGP--------QAPTG 115
                  V  R F+ +  LI  +      +    LQYP                      
Sbjct: 127 -------VGGRQFQTLPELIGYYTHISNILKNERLQYPAPPPEPVDDKKKVVATLPYNKV 179

Query: 116 RRDSDICLNA 125
               ++  +A
Sbjct: 180 PDTDELSFSA 189



 Score = 89.8 bits (222), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 21/118 (17%), Positives = 44/118 (37%), Gaps = 7/118 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +HG +S+E   + L   G  G +L+R+S+  PG Y L       I  +R+ + + 
Sbjct: 233 EGKVWFHGNVSKEEAAETLWKDGDIGGFLIRNSDKNPGDYSLSFRGPNTIQRFRIQKQQR 292

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
                        R++  +  ++  ++K +      L+ P      +     T     
Sbjct: 293 QYVM-------GGRYYNSLDAIVDHYKKEEIIDGFKLRDPTAPKKFKNQTTSTEDSSP 343


>UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=Euteleostomi
           RepID=GRB7_HUMAN
          Length = 532

 Score =  109 bits (272), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 21/104 (20%), Positives = 45/104 (43%), Gaps = 2/104 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                +HG+ISRE  ++L+   G +DG +L+R+S+  P  + L + +   +  Y +  +E
Sbjct: 427 RTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSE 486

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
                   +    +  F  +  L+   Q     +   L++   +
Sbjct: 487 EEG-RLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  108 bits (271), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 23/101 (22%), Positives = 42/101 (41%), Gaps = 9/101 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M     Y+G+I+R   EKLL +   +G++L+R SES PG + L V     +  ++V +  
Sbjct: 55  MKNHDWYYGRITRADAEKLL-SNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDA 113

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK--PDQGIVTPLQ 99
              +            F  +  L+   +     +     L+
Sbjct: 114 QSKFFL------WVVKFNSLNELVEYHRTASVSRSQDVKLR 148


>UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S7K1_TRIAD
          Length = 864

 Score =  108 bits (271), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 10/120 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+ +  Y+  +S E  E LL     DG++L+R S  VPG + L + Y+   + +R+ +  
Sbjct: 1   MENLANYYIDVSYEQAEDLLRLEDQDGAFLIRPSHRVPGTFALSIRYRNKFFHHRI-KVF 59

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G +  E   G  ++ F  +  L+  F++P+QG+  PL   V       P  PT   +S+
Sbjct: 60  HGRFVCE---GFTEKTFSSMDELVKHFRQPNQGLAHPLTKSVS------PPTPTEEDESN 110


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  108 bits (270), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 28/107 (26%), Positives = 43/107 (40%), Gaps = 9/107 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQ-GYIYTYRVSQTETGSW 64
            YHGK+ R   E+ L   G  GSYL+R+S+  PG + L  L Q   +  +R+       +
Sbjct: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIV-TPLQYPVEKSSGRGP 110
                  +  R F  + +LI  +      +    L YPV        
Sbjct: 241 -------IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVED 280



 Score = 94.5 bits (234), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 24/108 (22%), Positives = 45/108 (41%), Gaps = 6/108 (5%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +HGKIS++    LL+  G   S+L+R S++ PG Y L       I  +++  T  
Sbjct: 347 EGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPN 406

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
             +          R++  + ++I  ++K        L+ PV       
Sbjct: 407 NQFMMGG------RYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQ 448


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score =  108 bits (270), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 32/120 (26%), Positives = 55/120 (45%), Gaps = 9/120 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT- 59
           + +  YHGK+SRE  E LL   G  DGS+L+R+S S  G + L VL+   +  +++ +  
Sbjct: 5   EDIFWYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHS 64

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI--VTPLQYPVEKSSGRGPQAPTGRR 117
           E   +S +    +H      +++LI  +      +     L  PV+  +        GR 
Sbjct: 65  EDAFFSIDENTKIH-----GLESLIEHYVNTKGILSEGLSLTVPVKGDAPPDYSRRHGRT 119



 Score = 75.6 bits (185), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 19/95 (20%), Positives = 40/95 (42%), Gaps = 8/95 (8%)

Query: 6   VYHGKISRETGEKLLLA-TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            YHG + R   E  +   +  DG++L+R S+       L ++ +   Y Y + + +    
Sbjct: 286 WYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTLINESLFYNYIIRK-QDDYL 343

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQ 99
             +  P +       ++++I  +     G+ T LQ
Sbjct: 344 FIDNGPYLE-----SLEHIIEYYSFIPDGLPTVLQ 373


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score =  108 bits (270), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 25/110 (22%), Positives = 42/110 (38%), Gaps = 5/110 (4%)

Query: 3   AVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +   +H  ISR+  E LL      DGS+L+R S    G + L    +  +    +    T
Sbjct: 319 SEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRKNRVQHCHIKSRPT 378

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKSSGR 108
              +A     V  + F  + +LI+ +Q            L  PV + +  
Sbjct: 379 NDGTA-KYFLVGPKGFDNLYSLINHYQTNPLKSDKFELMLTEPVPQPNAH 427



 Score = 94.5 bits (234), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 19/102 (18%), Positives = 35/102 (34%), Gaps = 9/102 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSE--SVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            YH  ++R   E++L     D  +L+R          Y +     G I    + +     
Sbjct: 432 WYHENLTRLQAEEMLRRMRKDSYFLVRKRNDGDQNESYAISFRTGGTIKHCVIKKEGR-- 489

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                   +    F  +  LI+ ++K      T L+YP  + 
Sbjct: 490 -----LFMIGTAPFESLTELIAHYEKNPLYRKTKLKYPCNQD 526


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score =  107 bits (269), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 45/113 (39%), Gaps = 15/113 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +   +HG ++R+  E+LL     DG +L+R+S +  G + L  +  G      +    
Sbjct: 395 LQSKPWFHGHVTRKEAEQLLSH---DGDFLVRESTTTKGQFVLSGVQDGQYKHLLL-VDP 450

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGR 108
            G            R F  V +LIS  +         G V  L+ PV +   R
Sbjct: 451 NGVVR------TKDRQFDSVSHLISFHRDNTLPIVSSGSVLLLRQPVTRQIER 497


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  107 bits (269), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 28/111 (25%), Positives = 46/111 (41%), Gaps = 12/111 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     Y+G I+R   + LL   G DG +L+RDSE+  G Y + +   G    +RV    
Sbjct: 307 LVDKPWYYGSITRYMCDNLLNQRGHDGDFLIRDSETNVGDYSVSLKAPGRNKHFRVHVEG 366

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSS 106
                      + +R F  +  L+  +Q+       QG    L  P+ K +
Sbjct: 367 -------ALYCIGQRKFHTLDQLVDHYQRAPIYTNKQGEKLYLVRPLPKPT 410


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score =  107 bits (269), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 24/102 (23%), Positives = 37/102 (36%), Gaps = 11/102 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++       + 
Sbjct: 327 WFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGD-FFD 385

Query: 66  AETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPV 102
                      F  +  L+  + +        G    L+ P+
Sbjct: 386 LYGG-----EKFATLPELVQYYMENGELKEKNGQAIELKQPL 422


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score =  107 bits (269), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 20/99 (20%), Positives = 40/99 (40%), Gaps = 11/99 (11%)

Query: 1   MDAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY-----IYTY 54
           ++    +   +SR+  E +LL      GS+L+R+SES  G + L V          +  Y
Sbjct: 180 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 239

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQG 93
           ++   + G +         +  F  +  L+  + +   G
Sbjct: 240 KIRNLDNGGFYIS-----PRITFPGLHELVRHYTRYYNG 273


>UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax=Euteleostomi
           RepID=GRB10_HUMAN
          Length = 594

 Score =  107 bits (268), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 23/104 (22%), Positives = 46/104 (44%), Gaps = 2/104 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
                +HG+ISRE   +++   G +DG +LLRDS+S P  + L + +   I  +++   E
Sbjct: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
               +  +        F  +  L+  +Q     +   L++   +
Sbjct: 549 DDGQTFFSLDD-GNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 591


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score =  107 bits (268), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 25/111 (22%), Positives = 39/111 (35%), Gaps = 9/111 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E  L      G YL+R+SES    Y + +          V+QT+
Sbjct: 390 LEKQPWYHGAISRAEAESRLQPCKEAG-YLVRNSESGNSRYSIALKTSQGCVHIIVAQTK 448

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKSSG 107
              ++      V    F  +  ++  +              L YPV     
Sbjct: 449 DNKYTLNQTSAV----FDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHSKLH 495


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score =  107 bits (267), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 8/106 (7%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            YHG++ R T E+ L      GSYL+R+S+  PG Y L  L +  I  +R++      + 
Sbjct: 77  WYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRITAVCGDYY- 135

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPDQGI-VTPLQYPVEKSSGRGP 110
                 +  R F  + +L++ +      +    L +P         
Sbjct: 136 ------IGGRQFNSLMDLVAYYTHCSDLLKKERLIHPTPPPEPVND 175



 Score = 72.9 bits (178), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 19/96 (19%), Positives = 39/96 (40%), Gaps = 8/96 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + +H  +++     +L+  G  GS+L+R S++ PG Y L       I  +R+ +      
Sbjct: 245 SWFHPNVTKSEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQRFRIEKKG---- 299

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY 100
                  +  R F  +  +I+ ++K        L  
Sbjct: 300 ---VRYLMGGRTFECLDAVINRYRKEQIVEGHTLVQ 332


>UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925DBE
          Length = 249

 Score =  107 bits (267), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 31/126 (24%), Positives = 54/126 (42%), Gaps = 12/126 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT- 59
           ++ +  +HG ++R T E LLLA G++G+YL+R+S S PG Y + V  Q  I  Y +    
Sbjct: 49  IEDLPWFHGDMTRNTSEALLLANGVEGTYLVRNSASDPGSYTVSVRCQSSIKHYSLRHNV 108

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPVEKSSGRGPQAPT 114
              +++           +    +LI  F+       + G     +YP  K          
Sbjct: 109 HDNTYTFGRGF------YDSYNDLIDHFECKPVLTGETGEPVIFRYPYIKDVPEPSSYEK 162

Query: 115 GRRDSD 120
             R ++
Sbjct: 163 VLRHAE 168


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  106 bits (266), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 22/119 (18%), Positives = 40/119 (33%), Gaps = 7/119 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
           +++   + G ISR    + L A G   G++L+R SE     Y L V     +  Y++ + 
Sbjct: 73  VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
             G              F  +  L++  +         L  P  +     P       +
Sbjct: 133 AGGRLHLN-----EAVSFLSLPELVNYHRAQSLSHGLRLAAPC-RKHEPEPLPHWDDWE 185


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score =  106 bits (266), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 26/121 (21%), Positives = 44/121 (36%), Gaps = 15/121 (12%)

Query: 2   DAVTVYHGKIS-----RETGEKLLLA-----TGLDGSYLLRDSESVPGVYCLCVLYQGYI 51
                +HGK+      R   E+LL          DGS+L+R+SE+  G Y L     G +
Sbjct: 546 SNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKV 605

Query: 52  YTYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD---QGIVTPLQYPVEKSSGR 108
              R+   +                F  + +LI+ +Q+           L  PV +++  
Sbjct: 606 QHCRIHSRQDAG--TPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAH 663

Query: 109 G 109
            
Sbjct: 664 E 664



 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 8/104 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   YH  ++R   E +L+    DG++L+R   + P  Y +    +G I   RV Q   
Sbjct: 664 ESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKHCRVQQEGQ 722

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                     +    F  + +LIS ++K        L+YP+ + 
Sbjct: 723 -------TVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE 759


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score =  106 bits (266), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 26/109 (23%), Positives = 42/109 (38%), Gaps = 8/109 (7%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    YHG I+R   E +L     +GSYL+R+SES    Y L +         R+ + E
Sbjct: 1076 LERQGWYHGSITRIEAEAVLRLL-REGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNE 1134

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
              +       G   + F  +  ++  F      I       L +PV   
Sbjct: 1135 ELNAYI---LGQFSKPFDSIPEMVRHFSINRLPIRGAEHMCLLHPVIAQ 1180


>UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A9JR87_DANRE
          Length = 264

 Score =  106 bits (265), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 44/103 (42%), Gaps = 12/103 (11%)

Query: 6   VYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYQG-----YIYTYRVSQT 59
                +S+   E+LL+      GS+L+R+SE+ PG Y L V   G      +  YR+S  
Sbjct: 94  WQFVGLSKRKSEELLMLPHNQPGSFLIRESETFPGNYTLSVRKSGSQERASVKHYRISCI 153

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
           + G +            FR + ++I+ +     G+   L  P 
Sbjct: 154 DNGWFYIS-----PGLTFRTLSDMIAHYSV-SDGLCCTLGEPC 190


>UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Tetraodontidae RepID=Q4SUZ3_TETNG
          Length = 232

 Score =  106 bits (265), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 23/111 (20%), Positives = 45/111 (40%), Gaps = 10/111 (9%)

Query: 4   VTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
                  + R+  E+LL   G   GS+++R+S    G Y L V Y+  +  YR+ + +  
Sbjct: 83  HGWLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVKYR-SVKHYRIYRLDNS 141

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP 113
            +            F+ ++++I+ +     G+   L  P   +S   P   
Sbjct: 142 WYYIS-----PSLTFQCLEDMINHYC---DGLCCALTSPCLSASLPAPPTS 184


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  106 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 26/127 (20%), Positives = 51/127 (40%), Gaps = 10/127 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQGY---IYTYRV 56
           +     Y G ++R   E LLLA   D G++L+R SE     Y L VL       +   ++
Sbjct: 118 VKEQPWYFGTLNRFETEILLLAPENDVGAFLVRHSEKDNIGYVLSVLSGDRSREVKHIKI 177

Query: 57  SQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS-SGRGPQAPTG 115
            Q +  S+  +       + F+ ++ L+  + K      + L+ P  +        + + 
Sbjct: 178 HQNQNESFYLDK-----SQTFQSLEKLVDYYWKYSLDGDSFLKQPCRRPEPKPKDLSHST 232

Query: 116 RRDSDIC 122
             D ++ 
Sbjct: 233 VNDWELP 239


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score =  106 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 22/106 (20%), Positives = 53/106 (50%), Gaps = 13/106 (12%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HG+I+R+  EK+L   G  G +L+R+SE++PG + + V     +  ++V+++      
Sbjct: 291 WFHGRITRQDSEKILGCPGESGLFLIRESETMPGDFAVSVKAPERVKHFKVTRS------ 344

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPD------QGIVTPLQYPVEKS 105
            +    + +R F  + +L+  +++          +   L  P +++
Sbjct: 345 -DKKFCIGQRKFESLDDLVDHYKRSPIFSSDDGELKLYLTRPNQRN 389


>UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Ciona intestinalis
           RepID=UPI000180C238
          Length = 295

 Score =  106 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 26/110 (23%), Positives = 44/110 (40%), Gaps = 9/110 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  + Y G +SR+  +  LL     GS+L+RDS + PG Y L V     +  Y +++ E 
Sbjct: 10  DEDSWYFGMVSRKDSQNKLLHQ-KHGSFLVRDSTTCPGDYVLSVSENSKVSHYIINKQEN 68

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQ 111
                     +  + F  +  L+  ++       T L  P+ K       
Sbjct: 69  -------RLKIGDQMFDSMPELLDFYKVHYLD-TTTLIEPIPKPIKPQQT 110


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score =  106 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 25/119 (21%), Positives = 45/119 (37%), Gaps = 12/119 (10%)

Query: 6   VYHGKISRETGEKLLLATGLD-GSYLLRDSESVPGVYCLCVLYQG-----YIYTYRVSQT 59
              G  SR+  EK L+A G++ G +++RD    PG + L V         ++  YR+ + 
Sbjct: 7   WDFGMCSRQDAEKKLMAIGINKGQFIVRD--RDPGTFELSVRDNNPQKGDHVKHYRIWKM 64

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
           + G     +        F  V  L+  +Q    G+   L     K +         + +
Sbjct: 65  DGG----NSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKENPNTIGLGKDKWE 119


>UniRef50_C1BZH2 SH2 domain-containing protein 1A n=3 Tax=Euteleostei
           RepID=C1BZH2_ESOLU
          Length = 147

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 61/125 (48%), Positives = 72/125 (57%), Gaps = 9/125 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           + + VYHG  S+E GE  L   G DGSYL+R+SES  GVYCLCV          +     
Sbjct: 4   EKLPVYHGATSKEEGELRLWKDGRDGSYLIRNSESRDGVYCLCV---------LLFMDGE 54

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDI 121
           GSW+AETA GV +R+FRK+KNLISAFQKPDQGI T L YPV     R P     +     
Sbjct: 55  GSWTAETAAGVERRYFRKIKNLISAFQKPDQGIATHLLYPVTVQINRNPDGMKKKNTLAA 114

Query: 122 CLNAP 126
               P
Sbjct: 115 RHQLP 119


>UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (Fragment) n=1
           Tax=Ixodes scapularis RepID=B7P7A9_IXOSC
          Length = 358

 Score =  105 bits (263), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 25/113 (22%), Positives = 47/113 (41%), Gaps = 2/113 (1%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
               ++  +SRE   +LLL  G +DG +L+R S S PG + L   ++G ++  ++   E 
Sbjct: 239 TQPWFYSGMSREEATQLLLRHGTVDGVFLVRQSLSKPGTFVLSYAFRGTVHHVQIISVEE 298

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
                 +     +  F  +  L+  +Q     + T L + +     R    P 
Sbjct: 299 KDQLCYSLDS-GRTKFYDLLQLVEFYQLNLSYLPTKLTHFLVHQPRRRTTPPC 350


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score =  105 bits (262), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 26/109 (23%), Positives = 42/109 (38%), Gaps = 8/109 (7%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    YHG I+R   E +L     +GSYL+R+SES    Y L +         R+ + E
Sbjct: 1016 LERQGWYHGSITRIEAEAVLRLL-REGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNE 1074

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
              +       G   + F  +  ++  F      I       L +PV   
Sbjct: 1075 ELNAYI---LGQFSKPFDSIPEMVRHFSVNRLPIRGAEHMCLLHPVIAQ 1120


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score =  105 bits (262), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 45/105 (42%), Gaps = 8/105 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   YH  +SR   E +L+    DG++L+R   + P  + +    +G I   RV Q   
Sbjct: 743 ESKEWYHANLSRSQAENMLMRVPRDGAFLVRKR-AEPNSFAISFRAEGKIKHCRVQQEGQ 801

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
                     +    F  + +LIS ++K        L+YP+ + +
Sbjct: 802 -------TVVLGTSEFDSLVDLISYYEKHPLYRKMKLRYPINEDT 839



 Score =  103 bits (258), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 26/120 (21%), Positives = 45/120 (37%), Gaps = 15/120 (12%)

Query: 3   AVTVYHGKIS-----RETGEKLLLA-----TGLDGSYLLRDSESVPGVYCLCVLYQGYIY 52
               +HGK+      R+  E+LL          DGS+L+R+SE+  G Y L     G + 
Sbjct: 626 TEKWFHGKLGAGRDGRQIAERLLSEYCMETGAPDGSFLVRESETFVGDYTLSFWRSGRVQ 685

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD---QGIVTPLQYPVEKSSGRG 109
             R+   +     +          F  +  LI+ +Q+           L  PV +++   
Sbjct: 686 HCRIHSRQEAG--SPKFYLTDNLVFDTLFALINHYQQVALRCNEFEMKLTEPVPQTNAHE 743


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score =  105 bits (262), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 27/106 (25%), Positives = 44/106 (41%), Gaps = 9/106 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +++   YHG ISR   E LL     + SYL+R+SE+    + L +         ++S+T+
Sbjct: 353 LESQFWYHGAISRADAESLLRLC-KEASYLVRNSETNKIDFSLSLKSIQGFMHMKLSRTK 411

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
              +      G +   F  V  +I  +      I       L YPV
Sbjct: 412 ENKYVL----GHNSPPFNSVPEIIHHYASQKLPIKGAEHMSLLYPV 453


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 25/112 (22%), Positives = 42/112 (37%), Gaps = 15/112 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     +HG +SR   E +L     DG +L+R+S+  PG Y L  +         +    
Sbjct: 341 LKQEIWFHGSVSRAEAESMLTR---DGDFLVRESQGSPGQYVLTGMNNNTPKHLLLI-DP 396

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI-----VTPLQYPVEKSSG 107
            G            R F  V +L++        I     V  L+YP+ + + 
Sbjct: 397 EGVVR------TKDRVFDSVSHLVNHHCDNVLPIISADSVLVLRYPIPRRTN 442


>UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_SCHMA
          Length = 1264

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 55/124 (44%), Gaps = 8/124 (6%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++   ++GKI+RE  E+LL   G  +G +LLR+S +    Y + + + G ++ Y V +  
Sbjct: 45  ESTNYFYGKITREQAEELLFTNGANEGLFLLRESVNR--NYAVSICHLGRVHHYNVERHT 102

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
             S+  +T        F     L+        G +T  Q P+ +  G  P    G   +D
Sbjct: 103 DCSYRIQTG-----HKFIGPVELVQHHSTQLDGFLTLAQLPLNRPVGMSPIVLQGLNAND 157

Query: 121 ICLN 124
           +  N
Sbjct: 158 LEHN 161



 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 40/104 (38%), Gaps = 8/104 (7%)

Query: 4   VTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
              YH  I R   E  L + G  DG++L+R  +     Y L +  Q     YR+ +    
Sbjct: 200 QPWYHHTIRRYEAESRLASEGNQDGAFLVRYRKEDR-TYVLSLTSQNEPKHYRIEE---- 254

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS 106
                       ++F  +  LI  +     G++  LQ P+  S+
Sbjct: 255 --YLSRWSIEGGQYFETIMELIDHYHFRQDGLLCKLQKPIPVSN 296


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 41/109 (37%), Gaps = 9/109 (8%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    YHG I+R   E  L     +GS+L+R+ ES    Y L +         R+ + E
Sbjct: 1405 LERQGWYHGAITRIEAETTLRPL-SEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNE 1463

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
            TG +      G   R F  V  +I  F      +       L  PV   
Sbjct: 1464 TGQYIL----GQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQ 1508


>UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X6G9_CULQU
          Length = 109

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 39/105 (37%), Gaps = 12/105 (11%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
              +H  +S    EKLLL  G DGS+L R S S PG + L V     +   ++       
Sbjct: 2   ERWFHPSVSGVDAEKLLLERGFDGSFLARLSSSNPGAFTLSVRRGKEVTHIKIQNNGD-F 60

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKP------DQGIVTPLQYPV 102
           +            F  +  L+  + +         G +  L+ P+
Sbjct: 61  FDLYGG-----EKFATLSELVQYYMENGGQLKEKNGQIIELKQPL 100


>UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZG2_MONBE
          Length = 1021

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 40/103 (38%), Gaps = 7/103 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
           +  +HG ISR   E+LL    + G +L+R SE+  G Y L          Y V Q   G 
Sbjct: 825 MPWFHGLISRREAEELLRPRYI-GCFLVRVSENRFG-YTLSYRVSDRCRHYMVEQNTQGQ 882

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT-PLQYPVEKS 105
           ++      +       +  LI  FQ+         L+ P  + 
Sbjct: 883 YALVGVSKIA----DSLNELIEWFQRNPINEDMDMLREPCGQK 921


>UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_DROER
          Length = 220

 Score =  104 bits (260), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 24/102 (23%), Positives = 37/102 (36%), Gaps = 11/102 (10%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  IS    EKLL   G DGS+L R S S PG + L V     +   ++       + 
Sbjct: 52  WFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGD-FFD 110

Query: 66  AETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPV 102
                      F  +  L+  + +        G    L+ P+
Sbjct: 111 LYGG-----EKFATLPELVQYYMENGELKEKNGQAIELKQPL 147


>UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194BDF4
          Length = 1106

 Score =  104 bits (260), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 26/120 (21%), Positives = 44/120 (36%), Gaps = 15/120 (12%)

Query: 3   AVTVYHGKIS-----RETGEKLLLA-----TGLDGSYLLRDSESVPGVYCLCVLYQGYIY 52
               +HGK+      R+  EKLL        G DG++L+R+SE+  G Y L       + 
Sbjct: 384 TEKWFHGKLGGGRDGRQIAEKLLHEYCTETGGKDGTFLVRESETFVGDYTLSFWRSSRVQ 443

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD---QGIVTPLQYPVEKSSGRG 109
             R+   +     A          F  + +LI  +++           L  PV + +   
Sbjct: 444 HCRIHSRQEAG--ATKFYLTDNLVFDSLYSLICHYREVPLRCNEFEMRLTDPVPQPNAHE 501



 Score = 63.6 bits (154), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 12/45 (26%), Positives = 22/45 (48%), Gaps = 1/45 (2%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVL 46
           ++   YH  ++R   E +L+    DG++L+R   S P  Y +   
Sbjct: 501 ESKEWYHASLTRLQAEHMLMRVPRDGAFLVRKR-SEPNSYAISFR 544


>UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra magnipapillata
           RepID=UPI00019266B8
          Length = 237

 Score =  104 bits (260), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 28/129 (21%), Positives = 47/129 (36%), Gaps = 12/129 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++ +  +H  + R   E LLL  G DGSYLLR   +    Y L       +  +++S   
Sbjct: 5   VEDLGWFHSNLDRHQAEALLLHNGQDGSYLLRICTNNENSYVLSCRCANSVKHFQISY-- 62

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKSSGRGPQAPTG 115
            G +            F     L+  F+         G++T L+YP  +         T 
Sbjct: 63  DGKYY-----RFGMAIFETFSELVKHFENQPLLGGESGVLTLLKYPYPRRVNEPSSYETV 117

Query: 116 RRDSDICLN 124
              ++   N
Sbjct: 118 VIHAETGYN 126


>UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RJ03_TRIAD
          Length = 235

 Score =  104 bits (260), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 6/100 (6%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGS--YLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
              Y+G++ R   EKLLL+  +DG   +L+R SES  G + L V     I  +R+ + + 
Sbjct: 136 QPYYYGEMKRADAEKLLLSESVDGCNLFLIRKSESYKGEFALSVKENDDILHFRLPELQQ 195

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYP 101
            S             F  + +L+  F     G+   L  P
Sbjct: 196 DSLIIARKYI----EFISLDDLVQYFSLNSNGLCAKLTKP 231



 Score = 87.5 bits (216), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 21/105 (20%), Positives = 43/105 (40%), Gaps = 11/105 (10%)

Query: 6   VYHGKISRETGEKLLLAT-GLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
            +   +SR   +K+L       GS+ +R S++  G + L V     I  Y + +  +G +
Sbjct: 16  WFFTGLSRGDIDKMLYKKVNQQGSFAVRPSDTYLGDFSLSVKDGKRICHYLIRRLCSGHF 75

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
                    +  F  + +L++ +   + G+      P   SSG+ 
Sbjct: 76  LISV-----RVTFPSLLSLVTYYVDDNNGL-----KPCVDSSGKE 110


>UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9Y7_MONBE
          Length = 947

 Score =  104 bits (260), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 25/112 (22%), Positives = 42/112 (37%), Gaps = 9/112 (8%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET-- 61
              +HG I+R   E LL    + G +L R SE+  G Y L V  +     + + +T    
Sbjct: 837 HDWFHGVITRREAEDLLAPKPI-GCFLTRISETRLG-YTLSVRTRHACKHFVIEETRESP 894

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-KPDQGIVTPLQYPVEKSSGRGPQA 112
             +  +        +F  ++ LI  ++  P       L  P  +  GR    
Sbjct: 895 SRYMLQGR----DVYFDTLERLIEHYRGHPANDQGDHLTVPCGQPLGRPADY 942


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 27/96 (28%), Positives = 39/96 (40%), Gaps = 12/96 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHG++SR   EKLL A   DG +L+RDS + PG Y L  ++ G      +    
Sbjct: 473 LRQEPWYHGRMSRRAAEKLLRA---DGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL-VDP 528

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
            G              F  + +LI    K   G+  
Sbjct: 529 EGVVR------TKDVLFESISHLIDYHLKN--GLPI 556


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 30/128 (23%), Positives = 53/128 (41%), Gaps = 16/128 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     Y G+ISRE  + +L     DGS+L+RD+ S+ G Y L ++  G     ++   +
Sbjct: 27  LRMAPWYWGRISREEAKSILHGKP-DGSFLVRDALSMKGEYTLTLMKDGCEKLIKICHMD 85

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQG-----IVTPLQYPVEKSSGRGPQAPTG 115
                 ET        F  V  +I+ +++         +   L  P+ ++       P G
Sbjct: 86  RKYGFIETDL------FNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPHG 139

Query: 116 RRDSDICL 123
               D+CL
Sbjct: 140 ----DLCL 143



 Score = 73.7 bits (180), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 21/126 (16%), Positives = 47/126 (37%), Gaps = 15/126 (11%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
                  R   E++L      G++L+R      G Y L +  +  +    + +T TG   
Sbjct: 337 WLLKDAKRRNAEEMLKGAPS-GTFLIR--ARDAGHYALSIACKNIVQHCLIYETSTGF-- 391

Query: 66  AETAPGVHKRFFRKVKNLISAF-----QKPDQGIVTPLQYPVE--KSSGRGPQAPTGRRD 118
                      +  +K+L+  +     ++ +  + T L++PV   K++    Q    + +
Sbjct: 392 ---GFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPVLYWKNNPLQVQMIQLQEE 448

Query: 119 SDICLN 124
            D+   
Sbjct: 449 MDLEYE 454


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 6/104 (5%)

Query: 7   YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWSA 66
           +HG + R   E  +   G +G +L+R S S  G Y L V YQG    +++       +S 
Sbjct: 6   FHGSVPRAEAEAKVQRGG-NGVFLIRQSSSDSGSYVLSVGYQGEALHFKIKNEGECWFSI 64

Query: 67  ETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           +  P      F  + +L   F     G+   L  PV   S    
Sbjct: 65  DEGP-----VFEGLADLTEHFVHFPDGLPCNLTSPVLVRSAEID 103



 Score =  101 bits (251), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 24/117 (20%), Positives = 52/117 (44%), Gaps = 8/117 (6%)

Query: 3   AVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE- 60
            +  YHGK++R   E ++   G  DG +L+R S+   G + L + +    + +++  ++ 
Sbjct: 245 ELEYYHGKLNRVAAENIITIYGSNDGLFLVRFSKGS-GNFILSMCFNQSCFHFQIQCSQA 303

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
              +  +  PG     F  + +LI  ++    G+   L    ++S+  G  +P    
Sbjct: 304 ENCYFIDDGPG-----FTSLGDLIQHYRLKSDGLPCVLTRFCKRSARSGGLSPDEED 355


>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 43/106 (40%), Gaps = 9/106 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E LL     + SYL+R+SE+    + L +         ++S+T+
Sbjct: 375 LENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 433

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
              +      G +   F  V  ++  +      I       L YPV
Sbjct: 434 NNKYVL----GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 475


>UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001927133
          Length = 521

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 25/107 (23%), Positives = 39/107 (36%), Gaps = 8/107 (7%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +HG ISR   EK+L      GS+L+R SE V G Y +          + +  +  G   
Sbjct: 410 WFHGIISRHEAEKILEKKDK-GSFLVRVSERVWG-YTVSFKDIARCKHFLIDTSANGYQF 467

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPD-QGIV-TPLQYPVEKSSGRGP 110
                G  +     +  LI   +     G+    L YP  + +    
Sbjct: 468 F----GTEQIVHNSLNELIDYHKINPISGLGQEILIYPCGQETNPPD 510


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 8/91 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M+    Y G+ISRE  E LLL  G +G +L+RDSES PG   + +        ++V    
Sbjct: 296 MEQQPWYFGRISRERAEDLLL-HGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQN-- 352

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
                 +    +  R F  +  LI+ +    
Sbjct: 353 -----VDGLLKIGNRTFVDMNALINHYTTSP 378


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 27/112 (24%), Positives = 49/112 (43%), Gaps = 12/112 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +   + Y+G I+R   + +L   G DG +L+RDSE+  G Y + +   G    +RV   +
Sbjct: 443 LAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRVHVEQ 502

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVEKSSG 107
                      + +R F  +  L+  +Q+       QG    L   + K++G
Sbjct: 503 NMYC-------IGQRKFHSLDQLVDHYQRAPIYTNKQGEKLYLVRSLPKANG 547


>UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=1 Tax=Tribolium castaneum
           RepID=UPI0001757DDC
          Length = 952

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 28/123 (22%), Positives = 47/123 (38%), Gaps = 12/123 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     Y G I RE   + L  T  DG++L+RD+ +  G Y L +   G     ++   +
Sbjct: 543 LQEAEWYWGDIKREEVNEKLKETP-DGTFLVRDASTKSGEYTLTLRKGGTNKLIKI-CHK 600

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPVEKSSGRGPQAPTG 115
            G +            F  V  LI+ F+     + +  +   L YPV   +     A T 
Sbjct: 601 NGKYGF-----TEPYTFNSVVELINHFRNESLSQYNASLDIKLLYPVSMFNHEEEAAKTE 655

Query: 116 RRD 118
             +
Sbjct: 656 DVE 658



 Score = 71.0 bits (173), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 20/106 (18%), Positives = 37/106 (34%), Gaps = 10/106 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  T       R   EK L     DG++L+R S +    Y L +     +    +  T+ 
Sbjct: 831 DERTWLMLDCRRIDAEKYLAGQP-DGTFLIRTSSTSK--YALSIACNKMVNHCIIHDTKR 887

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPV 102
           G              +  +K+L+  +        +  + T L +P+
Sbjct: 888 GX--XXXXXXXPYNIYPTLKDLVLHYATNSLEIHNDSLNTVLAHPL 931


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 17/124 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +   T +HG I R    +LL     DG +LLR+S +  G + L     G +  ++V  T+
Sbjct: 465 IKEQTWFHGTIPRTESLRLLQQ---DGDFLLRESNNSLGDFVLSAKADGQVRHFKVQVTD 521

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSD 120
            G +            F  V NLIS   +         + PV K +      P  +    
Sbjct: 522 NGMYRF------EADQFPTVLNLISHHYQK--------REPVTKRTNCLLLNPICKDKWQ 567

Query: 121 ICLN 124
           +  +
Sbjct: 568 LSHD 571


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 31/110 (28%), Positives = 42/110 (38%), Gaps = 15/110 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     +HGK+SR   E LL    L+G +L+R+S + PG Y L  L  G      +    
Sbjct: 342 LRGEPWFHGKLSRREAEALLQ---LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL-VDP 397

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKS 105
            G              F  V +LIS            G    LQ PVE+ 
Sbjct: 398 EGVVR------TKDHRFESVSHLISYHVDNHLPIISAGSELCLQQPVERK 441


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 7/85 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             Y+GK++R   E  L   G +G +L+RDSES P  + + +  QG    ++V   E    
Sbjct: 84  PWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKE---- 139

Query: 65  SAETAPGVHKRFFRKVKNLISAFQK 89
              T   + +R F  ++ L+  ++K
Sbjct: 140 ---TVYCIGQRKFSTMEELVEHYKK 161


>UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=Euteleostomi
           RepID=SHD_MOUSE
          Length = 343

 Score =  103 bits (258), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 25/118 (21%), Positives = 41/118 (34%), Gaps = 13/118 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    +HG +SR   E LL     +GSYL+R SE+      L +         + ++T 
Sbjct: 220 LEKQPWFHGPLSRAEAENLLSLC-KEGSYLVRLSETRAQDCILSLRSNQGSMHLKFARTR 278

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTP------LQYPVEKSSGRGPQA 112
                     G H   F  +  L+  +    + +         L YPV  S       
Sbjct: 279 ENQVVL----GQHSGPFPSIPELVLHYS--ARPLPVQGAEHLALLYPVTSSQSSQGPC 330


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 23/112 (20%), Positives = 42/112 (37%), Gaps = 13/112 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ++R   E LL     + SYL+R S++    Y L +         + SQ+ 
Sbjct: 216 LEKQVWYHGALTRSEAESLLTLC-KECSYLVRKSQTSRNDYSLSLRSCHGFMHMKFSQSR 274

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTP------LQYPVEKSS 106
            G +      G +   F  +  +I  +      +         L +PV   +
Sbjct: 275 DGKFIL----GENSPPFDSIPEVIHFYTTNK--LPIRGAEHLSLLFPVLVQT 320


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 10/95 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHG++SR   E++L A   DG +L+RDS + PG Y L  ++ G      +    
Sbjct: 482 LRQEPWYHGRMSRRAAERMLRA---DGDFLVRDSVTNPGQYVLTGMHAGQPKHLLL-VDP 537

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV 95
            G              F  + +LI    +  Q IV
Sbjct: 538 EGVVR------TKDVLFESISHLIDHHLQNGQPIV 566


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 47/122 (38%), Gaps = 17/122 (13%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           ++  +H  ++    E+LL     DGS+L+R SES  G + + V   G +   ++      
Sbjct: 2   SLKWFHSSLNGSQAEELLTPLA-DGSFLVRPSESKHGDFTISVKCNGKVTHIKIQNDGDS 60

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
                         F  +++L+S ++      K   G+   L YPV     R     T R
Sbjct: 61  FLLI-----GSPDPFPTLESLVSHYRNTPNSIKEKSGVFIELLYPV-----RSTDPTTER 110

Query: 117 RD 118
             
Sbjct: 111 WY 112



 Score = 96.0 bits (238), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 26/105 (24%), Positives = 43/105 (40%), Gaps = 12/105 (11%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               YHG I  +  E++LL+ G  GSYL+R+S+S PG + L V     +    +S     
Sbjct: 108 TERWYHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQVIISC-RNK 166

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPD------QGIVTPLQYP 101
            +  ++ P      F  ++ LI  +                L+ P
Sbjct: 167 KYEIKSGPS-----FASLQELIEYYVMNPKLHDVKDQSPIKLREP 206


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 42/106 (39%), Gaps = 10/106 (9%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E LL     + SYL+R+S++    Y L +         ++++T+
Sbjct: 405 LEKQIWYHGAISRGDAENLLRLC-KECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTK 463

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
                     G +   F  V  +I  +      I       L YPV
Sbjct: 464 EKYV-----LGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPV 504


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/110 (22%), Positives = 41/110 (37%), Gaps = 15/110 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     +HG +SR+ GE LL     DG +L+R+S +    Y L  +  G      +    
Sbjct: 418 LYNEEWFHGPMSRKEGEPLLSN---DGDFLVRESTTAKDQYVLSGMQNGTPKHLLL-VDP 473

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKS 105
            G            + F  V +LI+  +         G    L+ PV + 
Sbjct: 474 QGKVR------TKDKEFDSVSHLINYHRNNRLPIISAGSAVHLKTPVVRK 517


>UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicini
           RepID=B0WI58_CULQU
          Length = 825

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 22/106 (20%), Positives = 45/106 (42%), Gaps = 7/106 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT- 59
           + +   YHG I R+  E+++     +G +L+RD  S PG Y L    +G    + +++  
Sbjct: 53  LRSHAWYHGPIPRQRAEEIVQ---KEGDFLVRDCVSQPGNYVLTCRTKGPTLHFVINKLL 109

Query: 60  -ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEK 104
            +  +             +  V +LI+ +     G    +Q+P  +
Sbjct: 110 IQPETVYERVQYQFEDDAYDTVPDLITFYVGSASG--ARIQFPCNR 153


>UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_DROME
          Length = 723

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 22/120 (18%), Positives = 45/120 (37%), Gaps = 14/120 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           M     +HG ++R    +++L +     G +L+R SE+  G + L   +QG     R++ 
Sbjct: 437 MSVFPWFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTI 496

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI------VTPLQYPVEKSSGRGPQA 112
           +E G    +        +F  ++ ++  F+     +         L   V   S      
Sbjct: 497 SEKGQCRVQHL------WFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVHSHSRLNDPT 550


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 19/88 (21%), Positives = 38/88 (43%), Gaps = 6/88 (6%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + +   Y G + R   E+ L     +G +L+R SE+  G Y + +   G I  ++V+   
Sbjct: 311 IHSRDWYFGNMKRADAEQRLQDRADNGEFLVRGSETSSGDYSISMKMPGRIRHFKVNTLP 370

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQ 88
            G +         +R F  +  L+  ++
Sbjct: 371 NGVFGI------GQRKFDSMDALLEHYK 392


>UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SVT4_TETNG
          Length = 1377

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 12/123 (9%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           ++   YH  ++R   E +L+    DG++L+R   S    Y +    +G I   R+ Q   
Sbjct: 683 ESREWYHSSLTRVQAEHMLMRVPRDGAFLVRKR-SEHNSYAISFRAEGKIKHCRIQQ--E 739

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSS-----GRGPQAPTGR 116
           G      +       F  + +L+S ++K        L+YP+ + +         +AP  R
Sbjct: 740 GRLFMLGSSA----EFESLMDLVSYYEKHPLYRKMKLRYPINEDTLDKMGTTVSRAPPER 795

Query: 117 RDS 119
           R S
Sbjct: 796 RRS 798



 Score =  102 bits (254), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 29/120 (24%), Positives = 46/120 (38%), Gaps = 16/120 (13%)

Query: 3   AVTVYHGKIS-----RETGEKLLLA----TGLDGSYLLRDSESVPGVYCLCVLYQGYIYT 53
           A   +HGK+      R+  EKLL         DG++L+R+SE+  G Y L     G +  
Sbjct: 567 AERWFHGKLGGGRDGRQVAEKLLQEYCEGGAKDGTFLVRESETFVGDYTLSFWRSGRVQH 626

Query: 54  YRVS-QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPD---QGIVTPLQYPVEKSSGRG 109
            R+  + E+GS             F  +  LI  ++            L  PV + +   
Sbjct: 627 CRIHSRQESGSTRF---YLTDNLVFDSLYRLICHYRDTPLRCNEFEMRLGNPVPQPNAHE 683


>UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DE57
          Length = 699

 Score =  102 bits (256), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 28/113 (24%), Positives = 41/113 (36%), Gaps = 7/113 (6%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           +  HG ISR   E LL+   L GS+L+R S+S PG Y L    +G    Y +       +
Sbjct: 589 SWLHGMISRREAENLLIDKPL-GSFLVRISQSRPG-YILTYRGEGRCRHYMIQVQPNARY 646

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPD-QGIVTPLQYPVEKSSGRGPQAPTGR 116
                     R    +  L+   Q    Q  +  L  P  + +         R
Sbjct: 647 VI----LGEDRAHASLTELVRYHQSVGIQPFMEVLTVPCGQFTSTPMSKSKER 695


>UniRef50_Q29CU6 GA13993 n=10 Tax=Neoptera RepID=Q29CU6_DROPS
          Length = 297

 Score =  102 bits (256), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 27/126 (21%), Positives = 51/126 (40%), Gaps = 6/126 (4%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  + Y G +SR+   ++L+     G +L+RDS S+ G Y LCV     +  Y +++ + 
Sbjct: 8   DKSSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQ 67

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT--GRRDS 119
                     +  + F  +  L++ +        TPL+ P +K   +        G    
Sbjct: 68  QDQIV---YRIGDQSFDNLPKLLTFYTLHYLD-TTPLRRPAQKKVEKVVGKFDFVGSDQD 123

Query: 120 DICLNA 125
           D+    
Sbjct: 124 DLPFQR 129


>UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2
           domain-containing-transforming protein C3) (Neuronal
           Shc) (N-Shc) (Protein Rai). n=15 Tax=Euteleostomi
           RepID=UPI0000ECC29C
          Length = 582

 Score =  102 bits (256), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 26/108 (24%), Positives = 42/108 (38%), Gaps = 15/108 (13%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               Y G++SR+  E+LL      G +L+R S + PG Y L  +  G      +     G
Sbjct: 484 EKPWYQGEMSRKEAEQLLKKC---GDFLVRKSTTNPGSYVLTGMQNGQAKHLLL-VDPEG 539

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPD-----QGIVTPLQYPVEKS 105
           +           R F  + +LI+   + +      G    LQ P E+ 
Sbjct: 540 TVR------TKDRVFDSISHLINHHLENNLPIVSSGSKLCLQQPAERK 581


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  102 bits (256), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/103 (24%), Positives = 48/103 (46%), Gaps = 12/103 (11%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            Y+GK++R   E +L   G+DG +L+RDSES+P  + + +        ++V     G + 
Sbjct: 236 WYYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISLKALYKNKHFKVLLN-DGFFC 294

Query: 66  AETAPGVHKRFFRKVKNLISAFQK-----PDQGIVTPLQYPVE 103
                   +R F  +++L+  ++K      + G    L  P+ 
Sbjct: 295 I------GQRKFSTMEDLVEHYKKAPIFTSEHGDKLYLIKPLT 331


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score =  102 bits (256), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 24/127 (18%), Positives = 49/127 (38%), Gaps = 14/127 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   YHG + R+  E+++     +G +L+RD  S P  Y L    +  +  + +++  
Sbjct: 236 LRSHAWYHGPLPRQRAEEIVQR---EGDFLVRDCASQPDNYVLSCRSKLAVLHFVLNKLV 292

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            +  +          +  F  V +LI+ +             P+  +SG   Q P  RR 
Sbjct: 293 LQPETVYERVQYQFEEDAFDTVPDLITFYVGSG--------KPISAASGALIQYPCNRRY 344

Query: 119 SDICLNA 125
             +    
Sbjct: 345 P-LSFYG 350


>UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4Q6F0_SCHMA
          Length = 1070

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 21/108 (19%), Positives = 48/108 (44%), Gaps = 10/108 (9%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    +H  ++R   E+L+     +GS+L+R SE+ P  + L + ++      ++++  
Sbjct: 967  LEEQPWFHPLLTRSEAEELIRNEP-EGSFLVRPSETCPNDFSLTIKHK-SFLHMKITRNS 1024

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKP----DQGIVTPLQYPVEK 104
            TG +      G + + +  V  +I  + +            L +PV K
Sbjct: 1025 TGQFIL----GEYSQPYASVSQMIYHYARTLVPVLGAYSVTLTHPVCK 1068


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 28/110 (25%), Positives = 42/110 (38%), Gaps = 15/110 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +     YHGK++R+  E LL+    DG +L+R+S +    Y L  L  G+     +    
Sbjct: 293 LQHEEWYHGKMNRKVAESLLVN---DGDFLIRESTTSACQYVLSGLQGGHPKHLLL-VDP 348

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKS 105
            G              F  V +LIS   +        G    L+ PV K 
Sbjct: 349 DGKVR------TKDHVFESVIHLISYHMENELPIISSGSELYLRKPVRKQ 392


>UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU33_DROPE
          Length = 1444

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 42/109 (38%), Gaps = 9/109 (8%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    YHG I+R   E  L     +GS+L+R+ ES    Y L +         R+ + E
Sbjct: 1339 LERQGWYHGAITRIEAETTLRPL-SEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNE 1397

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
            TG +      G   R F  V ++I  F      +       L  PV   
Sbjct: 1398 TGQYIL----GQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQ 1442


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 26/64 (40%), Positives = 42/64 (65%), Gaps = 1/64 (1%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  + YHG ISR   E LL ++G++GS+L+R+SES PG   + + Y+G +Y YR+S+  
Sbjct: 249 LEKHSWYHGPISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDP 307

Query: 61  TGSW 64
            G  
Sbjct: 308 DGKV 311


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 23/110 (20%), Positives = 44/110 (40%), Gaps = 9/110 (8%)

Query: 4   VTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
            + YHG I+R   E +L+A    G +L+RDS +  G Y L V     +  Y ++  +   
Sbjct: 8   YSWYHGDITRPACESILMAQ-KPGLFLVRDSSTCKGGYVLSVSENNKVSHYIIT-NKNSQ 65

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP 113
           +          + F  +  ++  +++      T L     + +   P  P
Sbjct: 66  YQI------GDQTFNDLPEIVEFYKRHFLD-TTTLVESAPRVTEPTPVTP 108


>UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS
          Length = 1495

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 42/109 (38%), Gaps = 9/109 (8%)

Query: 1    MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
            ++    YHG I+R   E  L     +GS+L+R+ ES    Y L +         R+ + E
Sbjct: 1390 LERQGWYHGAITRIEAETTLRPL-SEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNE 1448

Query: 61   TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKS 105
            TG +      G   R F  V ++I  F      +       L  PV   
Sbjct: 1449 TGQYIL----GQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQ 1493


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 43/106 (40%), Gaps = 9/106 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E LL     + SYL+R+SE+    + L +         ++S+T+
Sbjct: 133 LENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 191

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
              +      G +   F  V  ++  +      I       L YPV
Sbjct: 192 EHKYVL----GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 233


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 23/127 (18%), Positives = 48/127 (37%), Gaps = 14/127 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   YHG + R+  E+++     +G +L+RD  S P  Y L    +  +  + +++  
Sbjct: 235 LRSHAWYHGALPRQRAEEIVQR---EGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLV 291

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            +  +          +  F  V +LI+ +             P+  +SG   Q P  R  
Sbjct: 292 LQPETVYERVQYQFEEDAFDTVPDLITFYVGSG--------KPISSASGALIQFPCNRTY 343

Query: 119 SDICLNA 125
             +    
Sbjct: 344 P-LSFYG 349


>UniRef50_Q9VXH3 Small wing n=17 Tax=Drosophila RepID=Q9VXH3_DROME
          Length = 1236

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 26/118 (22%), Positives = 45/118 (38%), Gaps = 15/118 (12%)

Query: 4   VTVYHGKI--SRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVS-Q 58
              +HGK+   R+  + LL       DG++L+R+S +  G Y L    +      R+  +
Sbjct: 587 ENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSFWRRNRPNHCRIKLK 646

Query: 59  TETG--SWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKSSGRGPQ 111
            E G   +       V    F  + +LI  ++K           L+ PV +      Q
Sbjct: 647 HENGSIKYYL-----VENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQ 699



 Score = 91.0 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 19/104 (18%), Positives = 38/104 (36%), Gaps = 8/104 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           +    +H   ++E  E+ L    + GS+L+R S      + +       I   R+ Q   
Sbjct: 697 EDQEWFHPNTTKEQAEQGLYRLEI-GSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGR 755

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                    G+    F  + +LI+ + +        L +PV + 
Sbjct: 756 -------LYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQE 792


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 24/107 (22%), Positives = 42/107 (39%), Gaps = 8/107 (7%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             YHG++ R + E  L  +   GSYL+R+S+  PG Y L    +  I  +R++      +
Sbjct: 83  EWYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSYYGRTGINHFRITAVCGDFY 142

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIV-TPLQYPVEKSSGRGP 110
                  +  R F  + +L+  +      +    L  PV        
Sbjct: 143 -------IGGRQFISLSDLVGYYTSCSDLLKRERLAIPVAPPEPVND 182



 Score = 80.2 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 21/98 (21%), Positives = 40/98 (40%), Gaps = 8/98 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             +H   ++     +L+  G  GS+L+R S++ PG Y L       I  +R+ +      
Sbjct: 252 PWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQRFRIEKKG---- 306

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
                  +  R F  +  +I+ ++K        L +PV
Sbjct: 307 ---VRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPV 341


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score =  102 bits (255), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 43/106 (40%), Gaps = 9/106 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG ISR   E LL     + SYL+R+SE+    + L +         ++S+T+
Sbjct: 341 LENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 399

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPV 102
              +      G +   F  V  ++  +      I       L YPV
Sbjct: 400 EHKYVL----GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 441


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score =  102 bits (255), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 39/124 (31%), Gaps = 13/124 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRD-SESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     Y G ISRE     L     DG++L+RD S  + G Y L +   G     ++   
Sbjct: 60  LQDAEWYWGDISREEVNDKLRDMP-DGTFLVRDASTKMQGDYTLTLRKGGNNKLIKI-YH 117

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQG-----IVTPLQYPVEKSSGRGPQAPT 114
             G +            F  V  LI+ +           +   L YPV +          
Sbjct: 118 RDGKYGFS-----EPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSRFQQDQLVKED 172

Query: 115 GRRD 118
               
Sbjct: 173 NIDA 176



 Score = 95.2 bits (236), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 42/111 (37%), Gaps = 12/111 (10%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  T +   I+R   E LL     DG++L+R+S S  G Y   V+  G +    +  T  
Sbjct: 295 DEKTWFVEDINRVQAEDLLYGKP-DGAFLIRES-SKKGCYACSVVADGEVKHCVIYSTAR 352

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQ-----KPDQGIVTPLQYPVEKSSG 107
           G              +  +K L+  +Q     + +  +   L YPV     
Sbjct: 353 GY-----GFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMP 398


>UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=Neoptera
           RepID=Q17DJ2_AEDAE
          Length = 564

 Score =  102 bits (255), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 23/125 (18%), Positives = 45/125 (36%), Gaps = 14/125 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG--LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           M     +HG ++R    +L+L  G    G +L+R SE+  G + L   +QG     R++ 
Sbjct: 414 MREYPWFHGTLARSEAAQLVLHNGLSSHGVFLVRQSETRKGEFVLTFNFQGKAKHLRMTL 473

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI------VTPLQYPVEKSSGRGPQA 112
            + G    +        +F  +  ++  F++    +         L   V   S      
Sbjct: 474 NDLGQCRVQHL------WFPSITEMLEHFRQHPIPLESGGTADVTLTNFVVLPSHAMATN 527

Query: 113 PTGRR 117
            +   
Sbjct: 528 QSNSN 532


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score =  102 bits (254), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 27/98 (27%), Positives = 42/98 (42%), Gaps = 8/98 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD--GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +     +HG ISR    +L+   G D  G +L+R SE+  G Y L   +QG     R+S 
Sbjct: 366 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 425

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
           TE G    +         F  V +++  FQ+    +  
Sbjct: 426 TERGQCRVQHLH------FPSVVDMLHHFQRSPIPLEC 457


>UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, partial n=1 Tax=Tribolium
           castaneum RepID=UPI000175898D
          Length = 876

 Score =  102 bits (254), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 26/127 (20%), Positives = 47/127 (37%), Gaps = 14/127 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   YHG I R   E ++     +G +L+RD  S PG Y L    +     + +++  
Sbjct: 171 LRSHAWYHGAIPRSRAEDIVRE---EGGFLVRDCTSQPGNYVLTCRTKTQPLHFVINKII 227

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRD 118
            +  +          +  F  V +LI+ +             P+  +SG   Q P  R  
Sbjct: 228 LQPDTVYEHVQFQFEEDAFDTVPDLITFYVGSG--------KPITAASGARIQFPKNRMY 279

Query: 119 SDICLNA 125
             +   A
Sbjct: 280 P-LSFYA 285


>UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QLS5_SCHMA
          Length = 801

 Score =  102 bits (254), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 29/129 (22%), Positives = 49/129 (37%), Gaps = 11/129 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLY-----QGYIYTY 54
           ++A   Y   ISR+  E+LLL  G   G++L+R SE+  G   L V          +  Y
Sbjct: 393 VEAEDWYFRSISRKDSERLLLLKGNIRGTFLVRASETTNGALSLSVRDTEQQRGETVKHY 452

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT 114
           ++ Q+              K+ F  +K+L+  +     G+   L  P  +          
Sbjct: 453 KIKQSSE----TNDVYITTKQVFPDLKSLVIHYSNQADGLCCCLTRPCPRPPPVPTDLSR 508

Query: 115 -GRRDSDIC 122
             R   +I 
Sbjct: 509 LTRDQWEIS 517


>UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00004D6B5A
          Length = 321

 Score =  102 bits (254), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 8/98 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           + +   +HG ISR    +L+ + G++G   +L+R SE+  G Y L   +QG     R++ 
Sbjct: 218 LASSPWFHGPISRVKAAQLVQSQGVEGHGVFLVRQSETRRGEYVLTFNFQGRAKHLRLTL 277

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
           TE G    +         FR V  ++  F+     +  
Sbjct: 278 TERGQCHVQHL------RFRSVLEMLQYFRLQPIPLEC 309


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score =  102 bits (254), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 13/119 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   +HG ISRE  EKL+     +G +L+RDS S PG + L V ++G    + V++  
Sbjct: 121 VRSHAWFHGGISREKAEKLIRE---NGDFLVRDSISKPGNFVLTVRWKGVSMHFVVNKVV 177

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
            +  S  A       K  F  + +LI  +             PV ++SG   Q P  R 
Sbjct: 178 LKAHSPYASVQYQFEKECFDAIPSLIKFYVGNC--------RPVSQASGAVIQHPVNRT 228


>UniRef50_Q9XYM0 Adapter molecule Crk n=8 Tax=Endopterygota RepID=CRK_DROME
          Length = 271

 Score =  101 bits (253), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 26/126 (20%), Positives = 50/126 (39%), Gaps = 6/126 (4%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
           D  + Y G +SR+   ++L+     G +L+RDS S+ G Y LCV     +  Y +++ + 
Sbjct: 8   DRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQ 67

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPT--GRRDS 119
                     +  + F  +  L++ +        TPL+ P  +   +        G    
Sbjct: 68  QDQIV---YRIGDQSFDNLPKLLTFYTLHYLD-TTPLKRPACRRVEKVIGKFDFVGSDQD 123

Query: 120 DICLNA 125
           D+    
Sbjct: 124 DLPFQR 129


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score =  101 bits (253), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 28/127 (22%), Positives = 44/127 (34%), Gaps = 18/127 (14%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  IS    E +L + G+ GS+L R S    G + L V     +   R+  T    + 
Sbjct: 4   WFHRDISGLDAESVLKSRGVHGSFLARPSRKNQGDFSLSVRVGELVTHIRIQNTGD-FYD 62

Query: 66  AETAPGVHKRFFRKVKNLISAFQ------KPDQGIVTPLQYPVEKSSGRGPQAPTGRRDS 119
                      F  +  L+  +       +   G +  L+YP   S       PT  R  
Sbjct: 63  LYGG-----EKFATLSELVEYYTAENGILQDKDGTIIELKYPFNCS------DPTTERWY 111

Query: 120 DICLNAP 126
              L+ P
Sbjct: 112 HGHLSGP 118



 Score = 97.5 bits (242), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 24/113 (21%), Positives = 44/113 (38%), Gaps = 19/113 (16%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGY---------IYT 53
               YHG +S    EKLL      G++L+R+S S PG + L VL +           +  
Sbjct: 107 TERWYHGHLSGPNAEKLLWERDEPGTFLVRESLSKPGDFVLSVLTEEKSKASSGGRRVSH 166

Query: 54  YRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQK----PDQGIVTPLQYPV 102
            ++   +   ++        K  F  + +L+  +++       G    L+ P 
Sbjct: 167 IKI-MCQNDRYTVGG-----KEMFDTLADLMEHYKRKGIEEMSGTWVHLKQPY 213


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 20/85 (23%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             Y+G ++R   E  L   G++G +L+RDSES P  + + +   G    ++V        
Sbjct: 284 EWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQL------ 337

Query: 65  SAETAPGVHKRFFRKVKNLISAFQK 89
             +    + +R F  +  L+  ++K
Sbjct: 338 -VDNVYCIGQRRFHTMDELVEHYKK 361


>UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=Euteleostomi
           RepID=SHD_HUMAN
          Length = 340

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 25/113 (22%), Positives = 42/113 (37%), Gaps = 13/113 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    +HG ++R   E LL     +GSYL+R SE+ P    L +         + ++T 
Sbjct: 235 LEKQPWFHGPLNRADAESLLSLC-KEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTR 293

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTP------LQYPVEKSSG 107
                     G H   F  V  L+  +    + +         L YPV   + 
Sbjct: 294 ENQVVL----GQHSGPFPSVPELVLHYS--SRPLPVQGAEHLALLYPVVTQTP 340


>UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7Q1P4_IXOSC
          Length = 461

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 24/110 (21%), Positives = 43/110 (39%), Gaps = 15/110 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    +HG ISR+  E  L     DG +L+R+S+  PG + L  +         +    
Sbjct: 361 LEKEAWFHGAISRKESEGRLAE---DGDFLVRESQGNPGQFVLTGMQGSARRHLLL-VDP 416

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT-----PLQYPVEKS 105
            G            R F  V +L++  +     I++      L+ PV + 
Sbjct: 417 AGVVR------TKDRTFDSVSHLVNYHRDNALPIISAESALVLKNPVPRP 460


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
          Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 7/89 (7%)

Query: 3  AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
          A+  +   I+R+  E LL+    +G++L+R SES  G+Y L V Y   +  +R+ Q   G
Sbjct: 11 AMAWFFPTITRKNAELLLMQE-RNGAFLVRRSESSEGLYSLSVKYNESVQHFRILQDTAG 69

Query: 63 SWSAETAPGVHKRFFRKVKNLISAFQKPD 91
           +            F  +  L+  ++   
Sbjct: 70 KFHL------WIVKFPSLDALVDYYRTTS 92


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 26/110 (23%), Positives = 43/110 (39%), Gaps = 9/110 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++    YHG +SR   E LL     + SYL+R+SE+    Y L +         + SQ +
Sbjct: 286 LEKQVWYHGSLSRSEAESLLTLC-KECSYLVRNSETSRLDYSLSLRSCQGFMHMKFSQCK 344

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIV----TPLQYPVEKSS 106
            G +      G +   F  +  +I  +      I       L +PV   +
Sbjct: 345 DGRYIL----GQNSPPFETIPEVIHYYTTHKLPIKGAEHLSLLFPVLVQT 390


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 6/107 (5%)

Query: 5   TVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGS 63
             + G I+RE  E  L   G  DG YLLR S S  G Y L + Y    Y Y + +    +
Sbjct: 9   PYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDT 68

Query: 64  WSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGP 110
           ++         +  R   ++I+   +   G++  L+ P  +  G  P
Sbjct: 69  YAIAGG-----KSHRTPIDVINYHSQESDGLICLLKKPFHRPRGTEP 110



 Score = 91.0 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 22/115 (19%), Positives = 45/115 (39%), Gaps = 15/115 (13%)

Query: 2   DAVTVYHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVY------CLCVLYQGYIYTY 54
           + +  +HGKI RE  E +LL  + ++G      +++    +       LC+L+   +  Y
Sbjct: 159 EKMPWFHGKIDREDSELRLLNTSRVNGQI---SNQTKRKQWQKRVPNALCLLHNNQVMHY 215

Query: 55  RVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
           R+ +   G  S         + F  +  L+  +     G++  L     + S   
Sbjct: 216 RIDKDRAGKLSIPDG-----KKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHS 265


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  101 bits (253), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 17/86 (19%), Positives = 39/86 (45%), Gaps = 7/86 (8%)

Query: 6   VYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSWS 65
            +H  +SR   E LL+   + G +++R S+S PG + + V ++  +  ++V +   G++ 
Sbjct: 58  WFHEGLSRHQAENLLMGKEV-GFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYF 116

Query: 66  AETAPGVHKRFFRKVKNLISAFQKPD 91
                      F  +  L+  ++   
Sbjct: 117 L------WTEKFPSLNKLVDYYRTNS 136


>UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Fragment)
           n=8 Tax=Euteleostomi RepID=Q5T4P3_HUMAN
          Length = 206

 Score =  101 bits (253), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 39/124 (31%), Gaps = 13/124 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRD-SESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     Y G ISRE     L     DG++L+RD S  + G Y L +   G     ++   
Sbjct: 60  LQDAEWYWGDISREEVNDKLRDMP-DGTFLVRDASTKMQGDYTLTLRKGGNNKLIKI-YH 117

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQG-----IVTPLQYPVEKSSGRGPQAPT 114
             G +            F  V  LI+ +           +   L YPV +          
Sbjct: 118 RDGKYGFSDPL-----TFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKED 172

Query: 115 GRRD 118
               
Sbjct: 173 NIDA 176


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score =  101 bits (252), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 24/114 (21%), Positives = 46/114 (40%), Gaps = 9/114 (7%)

Query: 3   AVTVYHGKI--SRETGEKLLLATGL--DGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +   +HGK+   R   E LL       DG++L+R+S++  G + L    +  +   R+  
Sbjct: 557 SEKWFHGKLEGGRRKAEDLLKEYSYLGDGTFLVRESDTFVGDFSLSFWRKDSVNHCRIRS 616

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKP---DQGIVTPLQYPVEKSSGRG 109
            +    +      +    F  + +LI+ +QK     Q     L+ PV +     
Sbjct: 617 KQERGQT--KYYLIDNLAFDSLYSLITHYQKYPLRSQDFQQILKEPVPQPQSHH 668



 Score = 99.5 bits (247), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 20/101 (19%), Positives = 38/101 (37%), Gaps = 7/101 (6%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
             YH K+ R   E +L     DG++L+R +      Y +    +G I    + Q      
Sbjct: 671 PWYHEKLDRTRAEDMLKRIPSDGAFLVRQNGVDTNSYAISFRAEGKIKHCIIKQEGR--- 727

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                  +    F  +  L++ ++K        L++PV + 
Sbjct: 728 ----LFTIGNAQFESLVELVNYYEKKPLYRKMKLKHPVNEK 764


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  101 bits (252), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 15/109 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           ++  T YHG I R   ++LL     DG +L+R S+  PG Y L V + G    + V Q +
Sbjct: 523 LEQQTWYHGAIPRLEVQQLLT---KDGDFLVRKSQEKPG-YVLSVHWSGACKHFLV-QNK 577

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI----VTPLQYPVEKS 105
              +  +         F  +  LI  +Q   Q +       L+ PV K 
Sbjct: 578 DNMYCLDG------ESFHTIPQLIQQYQTSQQHVTKKSEVVLRRPVLKD 620


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 23/116 (19%), Positives = 44/116 (37%), Gaps = 14/116 (12%)

Query: 1   MDAVTVYHGKISRETGEKLLLATG--LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           M     +HG ++R    +L+L  G    G +L+R SE+  G + L   +QG     R++ 
Sbjct: 434 MREYPWFHGTLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTFNFQGKAKHLRMTL 493

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI------VTPLQYPVEKSSGR 108
            + G    +        +F  +  ++  F++    +         L   V   S  
Sbjct: 494 NDLGQCRVQHL------WFPSITEMLEHFRQHAIPLESGGTADVTLTNFVVLPSHA 543


>UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi RepID=SH2B3_HUMAN
          Length = 575

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 27/98 (27%), Positives = 42/98 (42%), Gaps = 8/98 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD--GSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +     +HG ISR    +L+   G D  G +L+R SE+  G Y L   +QG     R+S 
Sbjct: 359 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 418

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
           TE G    +         F  V +++  FQ+    +  
Sbjct: 419 TERGQCRVQHLH------FPSVVDMLHHFQRSPIPLEC 450


>UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepID=Q05DQ0_HUMAN
          Length = 283

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 39/124 (31%), Gaps = 13/124 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRD-SESVPGVYCLCVLYQGYIYTYRVSQT 59
           +     Y G ISRE     L     DG++L+RD S  + G Y L +   G     ++   
Sbjct: 60  LQDAEWYWGDISREEVNDKLRDMP-DGTFLVRDASTKMQGDYTLTLRKGGNNKLIKI-YH 117

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQG-----IVTPLQYPVEKSSGRGPQAPT 114
             G +            F  V  LI+ +           +   L YPV +          
Sbjct: 118 RDGKYGFSDPL-----TFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKED 172

Query: 115 GRRD 118
               
Sbjct: 173 NIDA 176


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 15/110 (13%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           + A T Y G++SR+  E LL     DG +L+R S + PG + L  ++ G      +    
Sbjct: 494 LQAETWYQGEMSRKEAEGLL---EKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL-VDP 549

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT-----PLQYPVEKS 105
            G            R F  + +LI+   +    IV+      LQ PVE+ 
Sbjct: 550 EG------TIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593


>UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID=Q7PSB5_ANOGA
          Length = 940

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 21/110 (19%), Positives = 45/110 (40%), Gaps = 9/110 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   YHG I R+  E+++     +G +L+RD  S PG Y L    +G    + +++  
Sbjct: 235 LRSHAWYHGPIPRQRAEEIVQ---KEGDFLVRDCVSQPGNYVLTCRTKGPTLHFVINKLL 291

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAF----QKPDQGIVTPLQYPVEK 104
            +  +             +  V +LI+ +    +         +Q+P  +
Sbjct: 292 LQPETVYERVQYQFEDDAYDTVPDLITFYVGSGKSISVASGARIQFPCNR 341


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 8/98 (8%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           + +   +HG ISR    +L+   GL+G   +L+R SE+  G Y L   +QG     R+S 
Sbjct: 383 LSSCPWFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLTFNFQGRAKHLRLSL 442

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
           TE G    +         F  +  ++  F +    +  
Sbjct: 443 TERGQCRVQHL------RFSSITEMLHHFHRYPIPLEC 474


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score =  101 bits (251), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 26/117 (22%), Positives = 44/117 (37%), Gaps = 13/117 (11%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ--T 59
            +   YHG I R+  E L+     DG +L+RDS S PG Y L   ++     +++++   
Sbjct: 154 RSHAWYHGAIPRQVAENLVQR---DGDFLIRDSLSSPGNYVLTCQWKNSPQHFKINKRVV 210

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGR 116
                 +       K  F  +  L+  +           + PV +  G     P  R
Sbjct: 211 AMNEAYSRVQYLFEKEGFDSIPALVRYYVGN--------REPVSEVIGAIIFQPINR 259


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score =  101 bits (251), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 42/112 (37%), Gaps = 15/112 (13%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
           +   YHGK+SR+  E LL+    DG +L+R+S + PG Y L  L  G      +     G
Sbjct: 523 SEECYHGKLSRKAAESLLV---KDGDFLVRESATSPGQYVLSGLQGGQAKHLLL-VDPEG 578

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKP-----DQGIVTPLQYPVEKSSGRG 109
                         F  V +LI             G    L+ PV K +   
Sbjct: 579 KVR------TKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPA 624


>UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9A03
          Length = 489

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 28/97 (28%), Positives = 43/97 (44%), Gaps = 8/97 (8%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQT 59
            A   +HG ISR     L+ ++G +G   +L+R SE+  G Y L   YQG     R+S T
Sbjct: 377 QAYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAKHLRLSLT 436

Query: 60  ETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
           E G    +         F  V +++S F+     +  
Sbjct: 437 EWGQCRVQHL------RFPSVMDMLSHFRLFPIPLEC 467


>UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D8F4
          Length = 792

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 20/89 (22%), Positives = 39/89 (43%), Gaps = 5/89 (5%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   YHG I R   E++L +   DG +L+RD  S PG + L    +G    + +++  
Sbjct: 69  LRSHAWYHGSIPRTRAEEILES---DGDFLVRDCTSQPGNFVLSTKCKGQNLHFVINKVV 125

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAF 87
            +  +             +  V +LI+ +
Sbjct: 126 LQPDTVYERIQFQFEDEAYDTVSDLITYY 154


>UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY34_ACYPI
          Length = 214

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 6/102 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRV--SQT 59
           +   YH  +SR+    +L A G  DG +L+R+S+S  G Y L     G I    +     
Sbjct: 103 SQPWYHKNMSRDQAANVLHALGNKDGVFLIRESKSKCGSYVLSFKCGGKIIHTPIVTQMD 162

Query: 60  E-TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQY 100
                       GV    F  +  L+  +Q     + T L +
Sbjct: 163 PLNDQVCFTLDNGV--IKFYDLLQLVEFYQLNAGSLPTRLMH 202


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 13/119 (10%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ-- 58
           + +   YHG + RE GE LL     DG +L+RDS S PG Y L   +      +++ +  
Sbjct: 19  LKSHAWYHGPLGREAGEALL---ERDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKIIRVV 75

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRR 117
                  +       +  F  V  LI              + P+ ++S      P  R 
Sbjct: 76  LRPKQGYSRELFQFEEDRFDNVPALIRFHVGS--------RRPISQASSAVIFHPITRT 126


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 29/119 (24%), Positives = 47/119 (39%), Gaps = 17/119 (14%)

Query: 5   TVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETGSW 64
           + +HG ISR+  E LL + G  G +L+R SE + G Y L    +     + +  T  G +
Sbjct: 324 SWFHGIISRQEAEDLL-SEGEPGHFLVRVSERILG-YVLSYRCKDEFKHFLIDAT-EGCY 380

Query: 65  SAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAPTGRRDSDICL 123
                   H+  F  +  L+   +            P+  S G     P G+R S +  
Sbjct: 381 ML----LGHQIRFTSLAELVEFHK----------GEPITMSGGEQLLQPCGQRPSGVDY 425


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 8/96 (8%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           +   +HG ISR     L+ ++G +G   +L+R SE+  G Y L   YQG     R+S TE
Sbjct: 407 SYPWFHGPISRVKAAHLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAKHLRLSLTE 466

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVT 96
            G    +         F  V +++S F+     +  
Sbjct: 467 WGQCRVQHL------RFPSVMDMLSHFRLYPIPLEC 496


>UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7P6T2_IXOSC
          Length = 702

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 48/115 (41%), Gaps = 13/115 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
           M +   YHG I R+  E+L+ A   DG +L+RD  S PG Y L   ++G    + +++  
Sbjct: 23  MRSHAWYHGTIPRQRAEELMTA---DGGFLVRDCVSRPGDYVLTCCWKGAPLHFVINKVV 79

Query: 61  TGSWSAET--APGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRGPQAP 113
              ++             F  V +L++ +           + P+  +SG     P
Sbjct: 80  LQPYTVYERIQYQFEDDCFDTVPDLVTFYVGN--------KRPISAASGAVVSRP 126


>UniRef50_A8Q2Q3 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q2Q3_BRUMA
          Length = 483

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 45/104 (43%), Gaps = 8/104 (7%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLDG--SYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           ++    +H ++SR    +L+L  G+DG   +L+R SE+ PG + L    QG     R+  
Sbjct: 323 LEIYPWFHARLSRSVSARLVLHNGVDGHGLFLVRQSETRPGEFVLTFNCQGKAKHVRIVM 382

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPV 102
              G          H+  F  + +L+  F+     + +    P+
Sbjct: 383 MPDGECRI------HQMIFETMVDLLEYFRDNPIPLESSSTPPI 420


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 17/90 (18%), Positives = 40/90 (44%), Gaps = 7/90 (7%)

Query: 2   DAVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTET 61
            +   +H  +SR   E LL+   + G +++R S+S PG + + V ++  +  ++V +   
Sbjct: 28  SSKRWFHEGLSRHQAENLLMGKEV-GFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNK 86

Query: 62  GSWSAETAPGVHKRFFRKVKNLISAFQKPD 91
           G++            F  +  L+  ++   
Sbjct: 87  GNYFL------WTEKFPSLNKLVDYYRTNS 110


>UniRef50_UPI000180BA50 PREDICTED: similar to growth factor receptor-bound protein 10 n=1
           Tax=Ciona intestinalis RepID=UPI000180BA50
          Length = 553

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 2/103 (1%)

Query: 2   DAVTVYHGKISRETGEKLLLATG-LDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTE 60
              T ++GKI+RE   + L   G +DG +L+RDS ++PG   + + +        ++Q E
Sbjct: 447 QTQTWFYGKITREEATEELHRNGNVDGLFLVRDSHTIPGGIVVTLCHNQKSRHIPITQIE 506

Query: 61  TGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVE 103
               +  TA     R F  +  L+   +     +   L +   
Sbjct: 507 RNGQNFYTADNGETR-FVDMIQLVDFHRLNKGSLPCLLLHECS 548


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 21/98 (21%), Positives = 35/98 (35%), Gaps = 14/98 (14%)

Query: 1   MDAVTVYHGKISRETGEKLLLATGLD--------GSYLLRDSESVPGVYCLCVLYQGYIY 52
           +     Y  + SR   E  LL T  D        G+++LR SE+ PG + + V     + 
Sbjct: 55  LYPHPWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVKEGSSVL 114

Query: 53  TYRVSQTETGSWSAETAPGVHKRFFRKVKNLISAFQKP 90
            +R+     G +            F  +  LI   +  
Sbjct: 115 HFRIFFDPKGKYYI------WTNKFDSINALIDYHRHQ 146


>UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=SH2B1_HUMAN
          Length = 756

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 14/120 (11%)

Query: 1   MDAVTVYHGKISRETGEKLLL--ATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQ 58
           +     +HG +SR    +L+L   TG  G +L+R SE+  G Y L   +QG     R+S 
Sbjct: 522 LSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSL 581

Query: 59  TETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGI------VTPLQYPVEKSSGRGPQA 112
            E G    +        +F+ + +++  F+     +         L   V  S  +    
Sbjct: 582 NEEGQCRVQHL------WFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPT 635


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 23/113 (20%), Positives = 41/113 (36%), Gaps = 16/113 (14%)

Query: 5   TVYHGKISRETGEK-LLLATGLDGSYLLRDSESVPGVYCLCVLYQGY------IYTYRVS 57
             Y   I R   ++ LLL     G+YL+R S S    Y L V +         +  YR+ 
Sbjct: 180 AWY--NIGRREADRKLLLVGNPQGTYLIRPS-SETQNYALSVRHYDSEKNMWVVKHYRIR 236

Query: 58  -QTETGSWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKSSGRG 109
                G +         +  F  +++L++ +     G+   L  P  ++    
Sbjct: 237 ILDNNGGFFISI-----RTTFPNIQDLVNYYTVHPDGLCCRLSIPCPRAYRPP 284


>UniRef50_Q4SKC0 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4SKC0_TETNG
          Length = 1249

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 21/103 (20%), Positives = 38/103 (36%), Gaps = 6/103 (5%)

Query: 3   AVTVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYRVSQTETG 62
               ++  +SR   E  L+    DG++L+R  E  P  + +     G +   R+ +  T 
Sbjct: 629 NEGWFYSDLSRGQAEDYLMRIPRDGAFLIRQREGEPDSFAITFKGDGKVKHCRIQKEGTR 688

Query: 63  SWSAETAPGVHKRFFRKVKNLISAFQKPDQGIVTPLQYPVEKS 105
                        +F  +  L+S F+         L+YPV   
Sbjct: 689 Y------LLGTTTYFESLVELVSYFRNRPLYRKIKLRYPVTPE 725



 Score = 97.2 bits (241), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 45/122 (36%), Gaps = 16/122 (13%)

Query: 3   AVTVYHGKI--SRETGEKLLLA-----TGLDGSYLLRDSESVPGVYCLCVLYQGYIYTYR 55
               +HG +   R+  E+L+        G DG++L+R S+ V   Y L     G +   R
Sbjct: 514 TEPWFHGHMKDGRQMAERLIYEYCAETGGQDGTFLVRPSDRVVLSYTLSFWRNGRVQHCR 573

Query: 56  VSQTETGS--WSAETAPGVHKRFFRKVKNLISAFQKPD---QGIVTPLQYPVEKSSGRGP 110
           V     G   +   TA       F  + +LI  +++     Q     L   V + S    
Sbjct: 574 VRVGNQGGRPYYFLTANLH----FPSLISLIQHYRENPLRCQDFELRLTDAVPQPSPHLN 629

Query: 111 QA 112
           + 
Sbjct: 630 EG 631


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.310    0.163    0.549 

Lambda     K      H
   0.267   0.0507    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 946,624,789
Number of Sequences: 3077464
Number of extensions: 42225041
Number of successful extensions: 108734
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 1101
Number of HSP's successfully gapped in prelim test: 919
Number of HSP's that attempted gapping in prelim test: 104214
Number of HSP's gapped (non-prelim): 2397
length of query: 126
length of database: 1,040,396,356
effective HSP length: 92
effective length of query: 34
effective length of database: 757,269,668
effective search space: 25747168712
effective search space used: 25747168712
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.9 bits)
S2: 88 (38.2 bits)
