Job Description P25911 Confidence 100.00% Date Wed Jul 10 14:04:52 BST 2013 Rank 71 Aligned Residues 257 % Identity 37% Template c3v5qB_ PDB info PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:nt-3 growth factor receptor; PDBTitle: discovery of a selective trk inhibitor with efficacy in rodent cancer2 tumor models Resolution 2.20 Å

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

		240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.		.	260	.	.	.	.	.	.	.	.	.		270	.	.	.	.	.	.	.		.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Predicted Secondary structure																					.												.									.
Query SS confidence																					.												.									.
Query Sequence		W	E	I	P	R	E	S	I	K	L	V	K	K	L	G	A	G	Q	F	.	G	E	V	W	M	G	Y	Y	N	N	S	.	T	K	V	A	V	K	T	L	.	K	P	G	T	M	S	V	Q	A	F	L	E	E	A	N	L	M	K	T
Query Conservation																					.												.									.
Alig confidence																					.												.									.
Template Conservation
Template Sequence		Q	H	I	K	R	R	D	I	V	L	K	R	E	L	G	F	K	V	F	L	A	E	C	Y	N	L	S	P	T	K	D	K	M	L	V	A	V	K	A	L	K	D	P	T	L	A	A	R	K	D	F	Q	R	E	A	E	L	L	T	N
Template Known Secondary structure						G	G	G																		S			S	S	S	S											S
Template Predicted Secondary structure
Template SS confidence
		531	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590
		297	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	Q	H	D	K	L	V	R	L	Y	A	V	V	T	K	E	E	P	I	Y	I	I	T	E	F	M	A	K	G	S	L	L	D	F	L	K	S	D	E	G	G	K	V	L	L	P	K	L	I	D	F	S	A	Q	I	A	E	G	M	A
Query Conservation
Alig confidence																		.	.																			.
Template Conservation																		.	.																			.
Template Sequence		L	Q	H	E	H	I	V	K	F	Y	G	V	C	G	D	P	.	.	L	I	M	V	F	E	Y	M	K	H	G	D	L	N	K	F	L	R	.	A	H	G	P	E	L	G	L	S	Q	M	L	H	I	A	S	Q	I	A	S	G	M	V
Template Known Secondary structure					T	T	B											.	.									T	T									.	T	T
Template Predicted Secondary structure																		.	.																			.
Template SS confidence
		595	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610			.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.		.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.
		357	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	I	E	R	K	N	Y	I	H	R	D	L	R	A	A	N	V	L	V	S	E	S	L	M	C	K	I	A	D	F	G	L	A	R	V	I	E	D	N	E	Y	T	A	R	E	G	A	K	F	P	I	K	W	T	A	P	E	A	I	N
Query Conservation
Alig confidence																																			.	.	.	.	.
Template Conservation																																			.	.	.	.	.
Template Sequence		Y	L	A	S	Q	H	F	V	H	R	D	L	A	T	R	N	C	L	V	G	A	N	L	L	V	K	I	G	D	F	G	M	D	.	.	.	.	.	V	Y	S	T	D	Y	Y	R	T	M	L	P	I	R	W	M	P	P	E	S	I	M
Template Known Secondary structure						T	T				S			S	G	G	G					G	G	G											.	.	.	.	.		S	G	G	G		B				B		G	G	G
Template Predicted Secondary structure																																			.	.	.	.	.
Template SS confidence
		669	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.						.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.
		417	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	G	C	F	T	I	K	S	D	V	W	S	F	G	I	L	L	Y	E	I	V	T	Y	G	K	I	P	Y	P	G	R	T	N	A	D	V	M	S	A	L	S	Q	G	Y	R	M	P	R	M	E	N	C	P	D	E	L	Y	D	I	M
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	R	K	F	T	T	E	S	D	V	W	S	F	G	V	I	L	W	E	I	F	T	Y	G	K	Q	P	W	F	Q	L	S	N	T	E	V	I	E	C	I	T	Q	G	R	V	L	E	R	P	R	V	C	P	K	E	V	Y	D	V	M
Template Known Secondary structure																						T	T	T	S			T	T	T	T	S												T							T	T
Template Predicted Secondary structure
Template SS confidence
		744	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.
		477	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	M	C	W	K	E	K	A	E	E	R	P	T	F	D	Y	L	Q	S	V	L	D	D	F	Y	T	A	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	G	C	W	Q	R	E	P	Q	Q	R	L	N	I	K	E	I	Y	K	I	L	H	A	L	G	K	A	T
Template Known Secondary structure							S	S	G	G	G	S																T
Template Predicted Secondary structure
Template SS confidence
		804	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.

No model constructed - rank, confidence too low

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D