Job Description P25911 Confidence 100.00% Date Wed Jul 10 14:04:52 BST 2013 Rank 281 Aligned Residues 256 % Identity 19% Template c2pvmA_ PDB info PDB header:transferase Chain: A: PDB Molecule:casein kinase ii subunit alpha; PDBTitle: structure-based design of pyrazolo[1,5-a][1,3,5]triazine2 derivatives as potent inhibitors of protein kinase ck2 Resolution 2.00 Å

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		242	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.		.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Predicted Secondary structure																												.
Query SS confidence																												.
Query Sequence		I	P	R	E	S	I	K	L	V	K	K	L	G	A	G	Q	F	G	E	V	W	M	G	Y	Y	N	.	N	S	T	K	V	A	V	K	T	L	K	P	G	T	M	S	V	Q	A	F	L	E	E	A	N	L	M	K	T	L	Q	H	D
Query Conservation																												.
Alig confidence																												.												.	.
Template Conservation																																								.	.
Template Sequence		G	E	Q	D	D	Y	E	V	V	R	K	V	G	R	G	K	Y	S	E	V	F	E	G	I	N	V	N	N	N	E	K	C	I	I	K	I	L	K	.	.	P	V	K	K	K	K	I	K	R	E	I	K	I	L	Q	N	L	G	G	P
Template Known Secondary structure				G	G	G											S	S									T	T	T											.	.	S																			T
Template Predicted Secondary structure																																								.	.
Template SS confidence
		34	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.			.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
		301	.	.	.	.	.	.	.	.	310	.	.	.			.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.
Predicted Secondary structure															.	.
Query SS confidence															.	.
Query Sequence		K	L	V	R	L	Y	A	V	V	T	K	E	E	.	.	P	I	Y	I	I	T	E	F	M	A	K	G	S	L	L	D	F	L	K	S	D	E	G	G	K	V	L	L	P	K	L	I	D	F	S	A	Q	I	A	E	G	M	A	Y	I
Query Conservation															.	.
Alig confidence															.	.																				.	.	.	.	.
Template Conservation																																				.	.	.	.	.
Template Sequence		N	I	V	K	L	L	D	I	V	R	D	Q	H	S	K	T	P	S	L	I	F	E	Y	V	N	N	T	D	F	K	V	L	Y	P	.	.	.	.	.	T	L	T	D	Y	D	I	R	Y	Y	I	Y	E	L	L	K	A	L	D	Y	C
Template Known Secondary structure		T	B										T	T	T																			G	G	.	.	.	.	.	G
Template Predicted Secondary structure																																				.	.	.	.	.
Template SS confidence
		93	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.						.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.
		359	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.		.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.
Predicted Secondary structure																						.
Query SS confidence																						.
Query Sequence		E	R	K	N	Y	I	H	R	D	L	R	A	A	N	V	L	V	S	E	S	.	L	M	C	K	I	A	D	F	G	L	A	R	V	I	E	D	N	E	Y	T	A	R	E	G	A	K	F	P	I	K	W	T	A	P	E	A	I	N	F
Query Conservation																						.
Alig confidence																						.																								.	.
Template Conservation																																														.	.
Template Sequence		H	S	Q	G	I	M	H	R	D	V	K	P	H	N	V	M	I	D	H	E	L	R	K	L	R	L	I	D	W	G	L	A	E	F	Y	H	P	G	K	E	Y	N	V	R	.	.	V	A	S	R	Y	F	K	G	P	E	L	L	V	D
Template Known Secondary structure				T	T							S	G	G	G					T	T	T	T								T	T						T	T					S		.	.		S		G	G	G							T	T
Template Predicted Secondary structure																																														.	.
Template SS confidence
		148	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.			.	.	.	.	.	.	.	.	200	.	.	.	.	.
			418	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Predicted Secondary structure		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		.	G	C	F	T	I	K	S	D	V	W	S	F	G	I	L	L	Y	E	I	V	T	Y	G	K	I	P	Y	P	G	R	T	N	A	D	V	M	S	A	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		L	Q	D	Y	D	Y	S	L	D	M	W	S	L	G	C	M	F	A	G	M	I	F	R	K	E	P	F	F	Y	G	H	D	N	H	D	Q	L	V	K	I	A	K	V	L	G	T	D	G	L	N	A	Y	L	N	K	Y	R	I	E	L
Template Known Secondary structure				S			T																	T		S	S	S	S			S	S																								T	T
Template Predicted Secondary structure
Template SS confidence
		206	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.
																	456	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.			.	.	.
Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Query SS confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Query Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L	S	Q	G	Y	R	M	P	R	M	E	N	C	P	D	E	L	Y	D	I	M	K	M	C	W	K	E	K	A	E	E	R	P	T	F	D	Y	L	Q	S	.	.	V	L	D
Query Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Template Conservation
Template Sequence		D	P	Q	L	E	A	L	V	G	R	H	S	R	K	P	W	L	K	F	M	N	A	D	N	Q	H	L	V	S	P	E	A	I	D	F	L	D	K	L	L	R	Y	D	H	Q	E	R	L	T	A	L	E	A	M	T	H	P	Y	F	Q
Template Known Secondary structure																	G	G	G	G			T	T	T	G	G	G											T	T			S	S	T	T	T	S									S	G	G	G
Template Predicted Secondary structure
Template SS confidence
		266	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.
		499	500	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	F	Y	T	A	T	E	G
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Q	V	R	A	A	E	N	S
Template Known Secondary structure								T
Template Predicted Secondary structure
Template SS confidence
		326	.	.	.	330	.	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D