Job Description P25911 Confidence 100.00% Date Wed Jul 10 14:04:52 BST 2013 Rank 4 Aligned Residues 433 % Identity 42% Template c1oplA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase Resolution 3.42 Å Model Dimensions (Å) X:77.373 Y:77.633 Z:53.466

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		64	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.			.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.
Predicted Secondary structure																																		.	.
Query SS confidence																																		.	.
Query Sequence		Q	G	D	I	V	V	A	L	Y	P	Y	D	G	I	H	P	D	D	L	S	F	K	K	G	E	K	M	K	V	L	E	E	.	.	H	G	E	W	W	K	A	K	S	L	S	S	K	R	E	G	F	I	P	S	N	Y	V	A	K	V
Query Conservation																																		.	.
Alig confidence																																		.	.									.	.
Template Conservation																																												.	.
Template Sequence		D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	.	.	T	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V
Template Known Secondary structure			T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S						.	.		S	S							G	G	G				S
Template Predicted Secondary structure																																												.	.
Template SS confidence
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.			.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.
		122	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	T	L	E	T	E	E	W	F	F	K	D	I	T	R	K	D	A	E	R	Q	L	L	A	P	G	N	S	A	G	A	F	L	I	R	E	S	E	T	L	K	G	S	F	S	L	S	V	R	D	Y	D	P	M	H	G	D	V	I	K
Query Conservation
Alig confidence																										.	.																								.	.	.	.	.
Template Conservation																										.	.																								.	.	.	.	.
Template Sequence		N	S	L	E	K	H	S	W	Y	H	G	P	V	S	R	N	A	A	E	Y	L	L	S	S	.	.	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	.	.	.	.	.	Y	E	G	R	V	Y
Template Known Secondary structure		S	S	G	G	G	S	T	T														G	G	G	.	.			T	T								S	S	S	T	T								.	.	.	.	.		T	T
Template Predicted Secondary structure																										.	.																								.	.	.	.	.
Template SS confidence
		139	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.			.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.						.	.	.	.	190	.
		182	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.
Predicted Secondary structure																																																										.	.	.	.
Query SS confidence																																																										.	.	.	.
Query Sequence		H	Y	K	I	R	S	L	D	N	G	G	Y	Y	I	S	P	R	I	T	F	P	C	I	S	D	M	I	K	H	Y	Q	K	Q	S	D	G	L	C	R	R	L	E	K	A	C	I	S	P	K	P	Q	K	P	W	D	K	.	.	.	.
Query Conservation																																																										.	.	.	.
Alig confidence																																																										.	.	.	.
Template Conservation
Template Sequence		H	Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y
Template Known Secondary structure									T	T	S				S	S	T	T	S		B	S	S									T	T			T	T	S	S	S										S					S	S	S		S	S	S
Template Predicted Secondary structure
Template SS confidence
		192	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.
		238	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.		.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Predicted Secondary structure																																	.
Query SS confidence																																	.
Query Sequence		D	A	W	E	I	P	R	E	S	I	K	L	V	K	K	L	G	A	G	Q	F	G	E	V	W	M	G	Y	Y	N	N	.	S	T	K	V	A	V	K	T	L	K	P	G	T	M	S	V	Q	A	F	L	E	E	A	N	L	M	K	T
Query Conservation																																	.
Alig confidence																																	.
Template Conservation
Template Sequence		D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L	K	E	A	A	V	M	K	E
Template Known Secondary structure		S			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		252	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.
		297	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	Q	H	D	K	L	V	R	L	Y	A	V	V	T	K	E	E	P	I	Y	I	I	T	E	F	M	A	K	G	S	L	L	D	F	L	K	S	D	E	G	G	K	V	L	L	P	K	L	I	D	F	S	A	Q	I	A	E	G	M	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E
Template Known Secondary structure					T	T	B									S	S	S	S									T	T		B								S		T	T	T	S
Template Predicted Secondary structure
Template SS confidence
		312	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.
		357	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	I	E	R	K	N	Y	I	H	R	D	L	R	A	A	N	V	L	V	S	E	S	L	M	C	K	I	A	D	F	G	L	A	R	V	I	E	D	N	E	Y	T	A	R	E	G	A	K	F	P	I	K	W	T	A	P	E	A	I	N
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A
Template Known Secondary structure						T	T				S			S	G	G	G					G	G	G							T	T						T	T							T	T					G	G	G
Template Predicted Secondary structure
Template SS confidence
		372	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.
		417	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	G	C	F	T	I	K	S	D	V	W	S	F	G	I	L	L	Y	E	I	V	T	Y	G	K	I	P	Y	P	G	R	T	N	A	D	V	M	S	A	L	S	Q	G	Y	R	M	P	R	M	E	N	C	P	D	E	L	Y	D	I	M
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M
Template Known Secondary structure																							T	T	S			S	S	T	T			T	T	T							T	T							T	T
Template Predicted Secondary structure
Template SS confidence
		432	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.
		477	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	M	C	W	K	E	K	A	E	E	R	P	T	F	D	Y	L	Q	S	V	L	D	D	F	Y	T	A	T	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S
Template Known Secondary structure					T		S	S	G	G	G	S												T	S		S	S	S
Template Predicted Secondary structure
Template SS confidence
		492	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520