Job Description P42682 Confidence 100.00% Date Tue Jul 30 13:16:14 BST 2013 Rank 139 Aligned Residues 257 % Identity 36% Template c3zbfA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase ros; PDBTitle: structure of human ros1 kinase domain in complex with crizotinib Resolution 2.20 Å

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

		265	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.					.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310			.	.	.	.	.	.	.	.
Predicted Secondary structure																														.	.	.	.																			.	.
Query SS confidence																														.	.	.	.																			.	.
Query Sequence		E	I	D	P	S	E	L	A	F	V	K	E	I	G	S	G	Q	F	G	V	V	H	L	G	E	W	R	A	.	.	.	.	H	I	P	V	A	I	K	A	I	N	E	G	S	M	S	E	E	D	.	.	F	I	E	E	A	K	V	M
Query Conservation																														.	.	.	.																			.	.
Alig confidence																														.	.	.	.																			.	.
Template Conservation
Template Sequence		A	F	P	R	E	K	L	T	L	R	L	L	L	G	S	G	E	V	Y	E	G	T	A	V	D	I	L	G	V	G	S	G	E	I	K	V	A	V	K	T	L	K	K	G	S	T	D	Q	E	K	I	E	F	L	K	E	A	H	L	M
Template Known Secondary structure		B			G	G	G																			T	S	S		S	S													S	S
Template Predicted Secondary structure
Template SS confidence
		1939	1940	.	.	.	.	.	.	.	.	.	1950	.	.	.	.	.	.	.	.	.	1960	.	.	.	.	.	.	.	.	.	1970	.	.	.	.	.	.	.	.	.	1980	.	.	.	.	.	.	.	.	.	1990	.	.	.	.	.	.	.	.
		319	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.							.	360	.	.	.	.	.	.	.	.	.	370	.	.
Predicted Secondary structure																																										.	.	.	.	.	.
Query SS confidence																																										.	.	.	.	.	.
Query Sequence		M	K	L	S	H	S	R	L	V	Q	L	Y	G	V	C	I	Q	Q	K	P	L	Y	I	V	T	E	F	M	E	N	G	C	L	L	D	Y	L	R	E	R	.	.	.	.	.	.	K	G	Q	L	Q	K	A	L	L	L	S	M	C	Q
Query Conservation																																										.	.	.	.	.	.
Alig confidence																																										.	.	.	.	.	.
Template Conservation
Template Sequence		S	K	F	N	H	P	N	I	L	K	Q	L	G	V	C	L	L	N	E	P	Q	Y	I	I	L	E	L	M	E	G	G	D	L	L	T	Y	L	R	K	A	R	M	A	T	F	Y	G	P	L	L	T	L	V	D	L	V	D	L	C	V
Template Known Secondary structure			T				T	T	B									S	S	S	S									T	T		B											S		T	T			S	S
Template Predicted Secondary structure
Template SS confidence
		2002	.	.	.	.	.	.	.	2010	.	.	.	.	.	.	.	.	.	2020	.	.	.	.	.	.	.	.	.	2030	.	.	.	.	.	.	.	.	.	2040	.	.	.	.	.	.	.	.	.	2050	.	.	.	.	.	.	.	.	.	2060	.
		373	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	I	C	E	G	M	A	Y	L	E	R	S	C	Y	I	H	R	D	L	A	A	R	N	C	L	V	S	S	A	C	V	V	K	I	S	D	F	G	M	A	R	Y	V	L	D	D	E	Y	I	S	S	S	G	A	K	F	P	V	K	W
Query Conservation
Alig confidence																																										.	.	.	.	.	.
Template Conservation																																										.	.	.	.	.	.
Template Sequence		D	I	S	K	G	C	V	Y	L	E	R	M	H	F	I	H	R	D	L	A	A	R	N	C	L	V	S	V	K	D	Y	T	S	P	R	I	V	K	I	G	.	.	.	.	.	.	D	F	G	L	A	R	D	I	Y	L	P	V	R	W
Template Known Secondary structure													T	T				S				G	G	G				S		S	S	S	S	S								.	.	.	.	.	.			T	T								G	G	G
Template Predicted Secondary structure																																										.	.	.	.	.	.
Template SS confidence
		2062	.	.	.	.	.	.	.	2070	.	.	.	.	.	.	.	.	.	2080	.	.	.	.	.	.	.	.	.	2090	.	.	.	.	.	.	.	.	.	2100	.							.	.	.	.	.	.	.	.	2110	.	.	.	.	.
		433	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		C	P	P	E	V	F	H	F	N	K	Y	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	V	F	T	E	G	K	M	P	F	E	N	K	S	N	L	Q	V	V	E	A	I	S	Q	G	F	R	L	Y	R	P	H	L	A	P
Query Conservation
Alig confidence
Template Conservation
Template Sequence		M	A	P	E	S	L	M	D	G	I	F	T	T	Q	S	D	V	W	S	F	G	I	L	I	W	E	I	L	T	L	G	H	Q	P	Y	P	A	H	S	N	L	D	V	L	N	Y	V	Q	T	G	G	R	L	E	P	P	R	N	C	P
Template Known Secondary structure		S																												T	T	S			S	S	T	T												T	T							T	T
Template Predicted Secondary structure
Template SS confidence
		2128	.	2130	.	.	.	.	.	.	.	.	.	2140	.	.	.	.	.	.	.	.	.	2150	.	.	.	.	.	.	.	.	.	2160	.	.	.	.	.	.	.	.	.	2170	.	.	.	.	.	.	.	.	.	2180	.	.	.	.	.	.	.
		493	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		M	T	I	Y	R	V	M	Y	S	C	W	H	E	S	P	K	G	R	P	T	F	A	E	L	L	Q	V	L	T	E	I	A	E	T	W
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	D	L	W	N	L	M	T	Q	C	W	A	Q	E	P	D	Q	R	P	T	F	H	R	I	Q	D	Q	L	Q	L	F	R	N	F	F
Template Known Secondary structure												T		S	S	G	G	G	S
Template Predicted Secondary structure
Template SS confidence
		2188	.	2190	.	.	.	.	.	.	.	.	.	2200	.	.	.	.	.	.	.	.	.	2210	.	.	.	.	.	.	.	.	.	2220	.	.

No model constructed - rank, confidence too low

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D