Job Description P48025 Confidence 100.00% Date Wed Jul 10 14:17:05 BST 2013 Rank 291 Aligned Residues 245 % Identity 18% Template c2pvmA_ PDB info PDB header:transferase Chain: A: PDB Molecule:casein kinase ii subunit alpha; PDBTitle: structure-based design of pyrazolo[1,5-a][1,3,5]triazine2 derivatives as potent inhibitors of protein kinase ck2 Resolution 2.00 Å

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		365	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	L	E	D	N	E	L	G	S	G	N	F	G	T	V	K	K	G	Y	Y	Q	M	K	K	V	V	K	T	V	A	V	K	I	L	K	N	E	A	N	D	P	A	L	K	D	E	L	L	A	E	A	N	V	M	Q	Q	L	D	N	P
Query Conservation
Alig confidence																												.	.											.	.	.	.	.
Template Conservation																												.	.											.	.	.	.	.
Template Sequence		Y	E	V	V	R	K	V	G	R	G	K	Y	S	E	V	F	E	G	I	N	V	N	N	N	E	K	.	.	C	I	I	K	I	L	K	P	V	K	.	.	.	.	.	K	K	K	I	K	R	E	I	K	I	L	Q	N	L	G	G	P
Template Known Secondary structure												S	S									T	T	T				.	.								S			.	.	.	.	.																	T
Template Predicted Secondary structure																												.	.											.	.	.	.	.
Template SS confidence
		39	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.			.	.	.	.	.	70	.	.	.	.						.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
		425	.	.	.	.	430	.	.	.	.	.	.				.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.
Predicted Secondary structure														.	.	.
Query SS confidence														.	.	.
Query Sequence		Y	I	V	R	M	I	G	I	C	E	A	E	.	.	.	S	W	M	L	V	M	E	M	A	E	L	G	P	L	N	K	Y	L	Q	Q	N	R	H	I	K	D	K	N	I	I	E	L	V	H	Q	V	S	M	G	M	K	Y	L	E	E
Query Conservation														.	.	.
Alig confidence														.	.	.																			.	.	.
Template Conservation																																			.	.	.
Template Sequence		N	I	V	K	L	L	D	I	V	R	D	Q	H	S	K	T	P	S	L	I	F	E	Y	V	N	N	T	D	F	K	V	L	Y	.	.	.	P	T	L	T	D	Y	D	I	R	Y	Y	I	Y	E	L	L	K	A	L	D	Y	C	H	S
Template Known Secondary structure		T	B										T	T	T																			G	.	.	.	G	G
Template Predicted Secondary structure																																			.	.	.
Template SS confidence
		93	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.				.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.
		482	.	.	.	.	.	.	.	490	.	.	.	.	.	.		.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Predicted Secondary structure																	.
Query SS confidence																	.
Query Sequence		S	N	F	V	H	R	D	L	A	A	R	N	V	L	L	.	V	T	Q	H	Y	A	K	I	S	D	F	G	L	S	K	A	L	R	A	D	E	N	Y	Y	K	A	Q	T	H	G	K	W	P	V	K	W	Y	A	P	E	C	I	N	Y
Query Conservation																	.
Alig confidence																	.																																.	.	.	.
Template Conservation																																																	.	.	.	.
Template Sequence		Q	G	I	M	H	R	D	V	K	P	H	N	V	M	I	D	H	E	L	R	K	L	R	L	I	D	W	G	L	A	E	F	Y	H	P	G	K	E	Y	N	V	R	V	A	S	R	Y	.	.	.	.	F	K	G	P	E	L	L	V	D
Template Known Secondary structure		T	T							S	G	G	G					T	T	T	T								T	T						T	T					S			S		G	G	.	.	.	.	G							T	T
Template Predicted Secondary structure																																																	.	.	.	.
Template SS confidence
		150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.					.	.	.	200	.	.	.	.	.
			541	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.
Predicted Secondary structure		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		.	Y	K	F	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	A	F	S	Y	G	Q	K	P	Y	R	G	M	K	G	S	E	V	T	A	M	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence		.																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		L	Q	D	Y	D	Y	S	L	D	M	W	S	L	G	C	M	F	A	G	M	I	F	R	K	E	P	F	F	Y	G	H	D	N	H	D	Q	L	V	K	I	A	K	V	L	G	T	D	G	L	N	A	Y	L	N	K	Y	R	I	E	L
Template Known Secondary structure				S			T																	T		S	S	S	S			S	S																								T	T
Template Predicted Secondary structure
Template SS confidence
		206	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.
																	579	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.
Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L	E	K	G	E	R	M	G	C	P	A	G	C	P	R	E	M	Y	D	L	M	N	L	C	W	T	Y	D	V	E	N	R	P	G	F	T	A	V	E	L	R	L	R	N	Y
Query Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																							.	.	.
Template Conservation																																																							.	.	.
Template Sequence		D	P	Q	L	E	A	L	V	G	R	H	S	R	K	P	W	L	K	F	M	N	A	D	N	Q	H	L	V	S	P	E	A	I	D	F	L	D	K	L	L	R	Y	D	H	Q	E	R	L	T	A	L	E	A	.	.	.	M	T	H	P
Template Known Secondary structure																	G	G	G	G			T	T	T	G	G	G											T	T			S	S	T	T	T	S							.	.	.			S	G
Template Predicted Secondary structure																																																							.	.	.
Template SS confidence
		266	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.				.	320	.	.
		624	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	Y	D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	F	Q
Template Known Secondary structure		G	G
Template Predicted Secondary structure
Template SS confidence
		323	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D