Job Description P48025 Confidence 100.00% Date Wed Jul 10 14:17:05 BST 2013 Rank 3 Aligned Residues 373 % Identity 40% Template c2fo0A_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase Resolution 2.27 Å Model Dimensions (Å) X:78.659 Y:70.863 Z:50.870

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		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.		.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.
Predicted Secondary structure																																				.
Query SS confidence																																				.
Query Sequence		E	K	M	P	W	F	H	G	N	I	S	R	D	E	S	E	Q	T	V	L	I	G	S	K	T	N	G	K	F	L	I	R	A	R	.	D	N	S	G	S	Y	A	L	C	L	L	H	E	G	K	V	L	H	Y	R	I	D	R	D	K
Query Conservation																																				.
Alig confidence																						.	.													.
Template Conservation																						.	.
Template Sequence		E	K	H	S	W	Y	H	G	P	V	S	R	N	A	A	E	Y	L	L	S	.	.	S	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	E	G	R	V	Y	H	Y	R	I	N	T	A	S
Template Known Secondary structure		G	G	S	T	T														T	S	.	.	S	S		T	T								S	S	S	T	T									T	T											T
Template Predicted Secondary structure																						.	.
Template SS confidence
		142	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.			.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.
		222	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	G	K	L	S	I	P	E	G	K	K	F	D	T	L	W	Q	L	V	E	H	Y	S	Y	K	P	D	G	L	L	R	V	L	T	V	P	C	Q	K	I	G	A	Q	M	G	H	P	G	S	P	N	A	H	P	V	T	W	S	P	G
Query Conservation
Alig confidence																																																						.	.	.	.	.	.	.	.
Template Conservation																																																						.	.	.	.	.	.	.	.
Template Sequence		D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	.	.	.	.	.	.	.	.
Template Known Secondary structure		T	S				S	S	T	T			B	S	S													T	T	S	S	S															S	S	S		S	S	T	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																																						.	.	.	.	.	.	.	.
Template SS confidence
		200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.
		282	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	I	I	S	R	I	K	S	Y	S	F	P	K	P	G	H	K	K	P	A	P	P	Q	G	S	R	P	E	S	T	V	S	F	N	P	Y	E	P	T	G	G	P	W	G	P	D	R	G	L	Q	R	E	A	L	P	M	D	T	E	V
Query Conservation
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		342	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	E	S	P	Y	A	D	P	E	E	I	R	P	K	E	V	Y	L	D	R	S	L	L	T	L	E	D	N	E	L	G	S	G	N	F	G	T	V	K	K	G	Y	Y	Q	M	K	K	V	V	K	T	V	A	V	K	I	L	K	N	E
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.													.																						.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.													.																						.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	D	K	W	E	M	E	R	T	D	I	T	M	.	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	.	.	L	T	V	A	V	K	T	L	K	E	D
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	T			B			G	G	G				.				S	G	G	G	T	T	S	S							G	G	G	T	.	.										T	T
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.													.																						.	.
Template SS confidence
															252	.	.	.	.	.	.	.	260	.	.	.		.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.			.	.	.	.	.	290	.	.	.	.	.
		402	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.		.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.			.	.
Predicted Secondary structure																																		.																								.	.
Query SS confidence																																		.																								.	.
Query Sequence		A	N	D	P	A	L	K	D	E	L	L	A	E	A	N	V	M	Q	Q	L	D	N	P	Y	I	V	R	M	I	G	I	C	.	E	A	E	S	W	M	L	V	M	E	M	A	E	L	G	P	L	N	K	Y	L	Q	Q	.	.	N	R
Query Conservation																																		.																								.	.
Alig confidence					.	.	.																											.																								.	.
Template Conservation					.	.	.
Template Sequence		T	M	E	.	.	.	V	E	E	F	L	K	E	A	A	V	M	K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q
Template Known Secondary structure		S			.	.	.																	T	T	B									S	S	S	S									T	T		B								S		T	T
Template Predicted Secondary structure					.	.	.
Template SS confidence
		296	.	.				.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.
		459	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	I	K	D	K	N	I	I	E	L	V	H	Q	V	S	M	G	M	K	Y	L	E	E	S	N	F	V	H	R	D	L	A	A	R	N	V	L	L	V	T	Q	H	Y	A	K	I	S	D	F	G	L	S	K	A	L	R	A	D	E	N
Query Conservation
Alig confidence																																																													.
Template Conservation																																																													.
Template Sequence		E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	.
Template Known Secondary structure		T	S																						T	T				S			S	G	G	G					G	G	G							T	T						S	S			.
Template Predicted Secondary structure																																																													.
Template SS confidence
		353	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.
		519	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	Y	K	A	Q	T	H	G	K	W	P	V	K	W	Y	A	P	E	C	I	N	Y	Y	K	F	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	A	F	S	Y	G	Q	K	P	Y	R	G	M	K	G	S	E	V	T	A	M
Query Conservation
Alig confidence		.
Template Conservation		.
Template Sequence		.	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y	E	L
Template Known Secondary structure		.					T	T					G	G	G																													T	T	S			S	S	T	T
Template Predicted Secondary structure		.
Template SS confidence
			412	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470
		579	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	E	K	G	E	R	M	G	C	P	A	G	C	P	R	E	M	Y	D	L	M	N	L	C	W	T	Y	D	V	E	N	R	P	G	F	T	A	V	E	L	R	L	R	N	Y	Y	Y	D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E
Template Known Secondary structure				T	T							T	T													T		S	S	G	G	G	S												T	S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		471	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.