Job Description P29351 Confidence 100.00% Date Wed Jul 10 14:09:17 BST 2013 Rank 1 Aligned Residues 529 % Identity 95% Template c3ps5A_ PDB info PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 Resolution 3.10 Å Model Dimensions (Å) X:86.593 Y:77.537 Z:50.586

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		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Predicted Secondary structure
Query SS confidence
Query Sequence		M	V	R	W	F	H	R	D	L	S	G	P	D	A	E	T	L	L	K	G	R	G	V	P	G	S	F	L	A	R	P	S	R	K	N	Q	G	D	F	S	L	S	V	R	V	D	D	Q	V	T	H	I	R	I	Q	N	S	G	D	F
Query Conservation
Alig confidence
Template Conservation
Template Sequence		M	V	R	W	F	H	R	D	L	S	G	L	D	A	E	T	L	L	K	G	R	G	V	H	G	S	F	L	A	R	P	S	R	K	N	Q	G	D	F	S	L	S	V	R	V	G	D	Q	V	T	H	I	R	I	Q	N	S	G	D	F
Template Known Secondary structure				S				S	S																T	T								S	S	S	T	T	S								T	T											S	S
Template Predicted Secondary structure
Template SS confidence
		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
		61	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	D	L	Y	G	G	E	K	F	A	T	L	T	E	L	V	E	Y	Y	T	Q	Q	Q	G	I	L	Q	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	C	S	D	P	T	S	E	R	W	Y	H	G	H	I	S	G	G	Q	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	D	L	Y	G	G	E	K	F	A	T	L	T	E	L	V	E	Y	Y	T	Q	Q	Q	G	V	L	Q	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	C	S	D	P	T	S	E	R	W	Y	H	G	H	M	S	G	G	Q	A
Template Known Secondary structure				S	S	S	S			B	S	S										T	T	S	S			B		S	S			B						B						S			S	T	T				S
Template Predicted Secondary structure
Template SS confidence
		61	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
		121	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Predicted Secondary structure
Query SS confidence
Query Sequence		E	S	L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F	V	L	S	V	L	N	D	Q	P	K	A	G	P	G	S	P	L	R	V	T	H	I	K	V	M	C	E	G	G	R	Y	T	V	G	G
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	T	L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F	V	L	S	V	L	S	D	Q	P	K	A	G	P	G	S	P	L	R	V	T	H	I	K	V	M	C	E	G	G	R	Y	T	V	G	G
Template Known Secondary structure											T	T								S	S	S	T	T												S	S	S	T	T	S										B		G	G	G		B	B	S	S	S
Template Predicted Secondary structure
Template SS confidence
		121	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
		181	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Predicted Secondary structure
Query SS confidence
Query Sequence		S	E	T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	S	G	A	F	V	Y	L	R	Q	P	Y	Y	A	T	R	V	N	A	A	D	I	E	N	R	V	L	E	L	N	K	K	Q	E	S	E	D	T	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	E	T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	S	G	A	F	V	Y	L	R	Q	P	Y	Y	A	T	R	V	N	A	A	D	I	E	N	R	V	L	E	L	N	K	K	Q	E	S	E	D	T	A
Template Known Secondary structure		S			B	S	S											S		B			T	T	S			B													G	G	G														S	S	S
Template Predicted Secondary structure
Template SS confidence
		181	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
		241	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Predicted Secondary structure
Query SS confidence
Query Sequence		K	A	G	F	W	E	E	F	E	S	L	Q	K	Q	E	V	K	N	L	H	Q	R	L	E	G	Q	R	P	E	N	K	S	K	N	R	Y	K	N	I	L	P	F	D	H	S	R	V	I	L	Q	G	R	D	S	N	I	P	G	S	D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		K	A	G	F	W	E	E	F	E	S	L	Q	K	Q	E	V	K	N	L	H	Q	R	L	E	G	Q	R	P	E	N	K	G	K	N	R	Y	K	N	I	L	P	F	D	H	S	R	V	I	L	Q	G	R	D	S	N	I	P	G	S	D
Template Known Secondary structure														G	G	G	G	G						T	G	G	G		G	G	G	G	G	G		S		S	S					T	T	T						S			S	S	S	T	T	T	T
Template Predicted Secondary structure
Template SS confidence
		241	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
		301	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	I	N	A	N	Y	V	K	N	Q	L	L	G	P	D	E	N	S	K	T	Y	I	A	S	Q	G	C	L	D	A	T	V	N	D	F	W	Q	M	A	W	Q	E	N	T	R	V	I	V	M	T	T	R	E	V	E	K	G	R	N	K
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	I	N	A	N	Y	I	K	N	Q	L	L	G	P	D	E	N	A	K	T	Y	I	A	S	Q	G	C	L	E	A	T	V	N	D	F	W	Q	M	A	W	Q	E	N	S	R	V	I	V	M	T	T	R	E	V	E	K	G	R	N	K
Template Known Secondary structure											S	S	S		T	T														T	T	T											T	T								S		S	B	S	S	S	S	B	S
Template Predicted Secondary structure
Template SS confidence
		301	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
		361	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Predicted Secondary structure
Query SS confidence
Query Sequence		C	V	P	Y	W	P	E	V	G	T	Q	R	V	Y	G	L	Y	S	V	T	N	S	R	E	H	D	T	A	E	Y	K	L	R	T	L	Q	I	S	P	L	D	N	G	D	L	V	R	E	I	W	H	Y	Q	Y	L	S	W	P	D	H
Query Conservation
Alig confidence
Template Conservation
Template Sequence		C	V	P	Y	W	P	E	V	G	M	Q	R	A	Y	G	P	Y	S	V	T	N	C	G	E	H	D	T	T	E	Y	K	L	R	T	L	Q	V	S	P	L	D	N	G	D	L	I	R	E	I	W	H	Y	Q	Y	L	S	W	P	D	H
Template Known Secondary structure						S			B	T						T	T												S	S											S	S			S															S	S
Template Predicted Secondary structure
Template SS confidence
		361	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
		421	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Predicted Secondary structure
Query SS confidence
Query Sequence		G	V	P	S	E	P	G	G	V	L	S	F	L	D	Q	I	N	Q	R	Q	E	S	L	P	H	A	G	P	I	I	V	H	C	S	A	G	I	G	R	T	G	T	I	I	V	I	D	M	L	M	E	S	I	S	T	K	G	L	D	C
Query Conservation
Alig confidence
Template Conservation
Template Sequence		G	V	P	S	E	P	G	G	V	L	S	F	L	D	Q	I	N	Q	R	Q	E	S	L	P	H	A	G	P	I	I	V	H	S	S	A	G	I	G	R	T	G	T	I	I	V	I	D	M	L	M	E	N	I	S	T	K	G	L	D	C
Template Known Secondary structure		S	S		S		S																		T	T									S	S	S	S																					S	S
Template Predicted Secondary structure
Template SS confidence
		421	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
		481	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	I	D	I	Q	K	T	I	Q	M	V	R	A	Q	R	S	G	M	V	Q	T	E	A	Q	Y	K	F	I	Y	V	A	I	A	Q	F	I	E	T	T	K	K	K	L	E	I	I	Q	S	Q
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	I	D	I	Q	K	T	I	Q	M	V	R	A	Q	R	S	G	M	V	Q	T	E	A	Q	Y	K	F	I	Y	V	A	I	A	Q	F	I	E	T	T	K	K	K	L	E	V	L	Q	S	Q
Template Known Secondary structure														T	T	S	T	T	S	S		S																				T	T	T	T	T	T	S
Template Predicted Secondary structure
Template SS confidence
		481	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.