Job Description P29351 Confidence 100.00% Date Wed Jul 10 14:09:17 BST 2013 Rank 3 Aligned Residues 488 % Identity 61% Template c2shpA_ PDB info PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 Resolution 2.00 Å Model Dimensions (Å) X:64.351 Y:80.713 Z:60.953

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		3	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	W	F	H	R	D	L	S	G	P	D	A	E	T	L	L	K	G	R	G	V	P	G	S	F	L	A	R	P	S	R	K	N	Q	G	D	F	S	L	S	V	R	V	D	D	Q	V	T	H	I	R	I	Q	N	S	G	D	F	Y	D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	W	F	H	P	N	I	T	G	V	E	A	E	N	L	L	L	T	R	G	V	D	G	S	F	L	A	R	P	S	K	S	N	P	G	D	L	T	L	S	V	R	R	N	G	A	V	T	H	I	K	I	Q	N	T	G	D	Y	Y	D
Template Known Secondary structure		T	T	B		S	S																T	T								S	S	S	T	T									T	T										S	S	S
Template Predicted Secondary structure
Template SS confidence
		5	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.
		63	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	Y	G	G	E	K	F	A	T	L	T	E	L	V	E	Y	Y	T	Q	Q	Q	G	I	L	Q	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	C	S	D	P	T	S	E	R	W	Y	H	G	H	I	S	G	G	Q	A	E	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	Y	G	G	E	K	F	A	T	L	A	E	L	V	Q	Y	Y	M	E	H	H	G	Q	L	K	E	K	N	G	D	V	I	E	L	K	Y	P	L	N	C	A	D	P	T	S	E	R	W	F	H	G	H	L	S	G	K	E	A	E	K
Template Known Secondary structure			T	T	S				S	S										T		T	T		S	B	S	S	S	S		B													T	T		T	T	B			S
Template Predicted Secondary structure
Template SS confidence
		65	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.
		123	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F	V	L	S	V	L	N	D	Q	P	K	A	G	P	G	S	P	L	R	V	T	H	I	K	V	M	C	E	G	G	R	Y	T	V	G	G	S	E
Query Conservation
Alig confidence																																		.	.	.	.
Template Conservation																																		.	.	.	.
Template Sequence		L	L	T	E	K	G	K	H	G	S	F	L	V	R	E	S	Q	S	H	P	G	D	F	V	L	S	V	R	T	G	D	N	.	.	.	.	D	G	K	S	K	V	T	H	V	M	I	R	C	Q	E	L	K	Y	D	V	G	G	G	E
Template Known Secondary structure						T			T	T								S	S	S	T	T												.	.	.	.															T	T				S	S	S	S
Template Predicted Secondary structure																																		.	.	.	.
Template SS confidence
		125	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.					.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
		183	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	S	G	A	F	V	Y	L	R	Q	P	Y	Y	A	T	R	V	N	A	A	D	I	E	N	R	V	L	E	L	N	K	K	Q	E	S	E	D	T	A	K	A
Query Conservation
Alig confidence																																																				.	.	.	.	.	.	.	.	.	.
Template Conservation																																																				.	.	.	.	.	.	.	.	.	.
Template Sequence		R	F	D	S	L	T	D	L	V	E	H	Y	K	K	N	P	M	V	E	T	L	G	T	V	L	Q	L	K	Q	P	L	N	T	T	R	I	N	A	A	E	I	E	S	R	V	R	E	L	S	K	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure			B	S	S											S			B		T	T	S		B										S				G	G	G											.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																																				.	.	.	.	.	.	.	.	.	.
Template SS confidence
		186	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	F	W	E	E	F	E	S	L	Q	K	Q	E	V	K	N	L	H	Q	R	L	E	G	Q	R	P	E	N	K	S	K	N	R	Y	K	N	I	L	P	F	D	H	S	R	V	I	L	Q	G	R	D	S	N	I	P	G	S	D	Y	I
Query Conservation
Alig confidence																																																		.	.	.	.	.	.	.
Template Conservation																																																		.	.	.	.	.	.	.
Template Sequence		G	F	W	E	E	F	E	T	L	Q	Q	Q	E	C	K	L	L	Y	S	R	K	E	G	Q	R	Q	E	N	K	N	K	N	R	Y	K	N	I	L	P	F	D	H	T	R	V	V	L	H	.	.	.	.	.	.	.	D	S	D	Y	I
Template Known Secondary structure												G	G	G	G	G	G									S	G	G	G	G	G	G	S	S	S	T	T					T	T	T						.	.	.	.	.	.	.
Template Predicted Secondary structure																																																		.	.	.	.	.	.	.
Template SS confidence
		246	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.								.	.	.	.	.
		303	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	A	N	Y	V	K	N	Q	L	L	G	P	D	E	N	S	K	T	Y	I	A	S	Q	G	C	L	D	A	T	V	N	D	F	W	Q	M	A	W	Q	E	N	T	R	V	I	V	M	T	T	R	E	V	E	K	G	R	N	K	C	V
Query Conservation
Alig confidence										.	.	.	.	.	.	.	.
Template Conservation										.	.	.	.	.	.	.	.
Template Sequence		N	A	N	I	I	M	P	K	.	.	.	.	.	.	.	.	K	S	Y	I	A	T	Q	G	C	L	Q	N	T	V	N	D	F	W	R	M	V	F	Q	E	N	S	R	V	I	V	M	T	T	K	E	V	E	R	G	K	S	K	C	V
Template Known Secondary structure										.	.	.	.	.	.	.	.											T	T	T												T								S		S			T	T			S
Template Predicted Secondary structure										.	.	.	.	.	.	.	.
Template SS confidence
		306	.	.	.	310	.	.	.									.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.
		363	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	Y	W	P	E	V	G	T	Q	R	V	Y	G	L	Y	S	V	T	N	S	R	E	H	D	T	A	E	Y	K	L	R	T	L	Q	I	S	P	L	D	N	G	D	L	V	R	E	I	W	H	Y	Q	Y	L	S	W	P	D	H	G	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		K	Y	W	P	D	E	Y	A	L	K	E	Y	G	V	M	R	V	R	N	V	K	E	S	A	A	H	D	Y	T	L	R	E	L	K	L	S	K	V	G	Q	G	N	T	E	R	T	V	W	Q	Y	H	F	R	T	W	P	D	H	G	V
Template Known Secondary structure				S			T	T						T	T												S	S											T	T																		S	S	S
Template Predicted Secondary structure
Template SS confidence
		369	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.
		423	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	S	E	P	G	G	V	L	S	F	L	D	Q	I	N	Q	R	Q	E	S	L	P	H	A	G	P	I	I	V	H	C	S	A	G	I	G	R	T	G	T	I	I	V	I	D	M	L	M	E	S	I	S	T	K	G	L	D	C	D	I
Query Conservation
Alig confidence
Template Conservation
Template Sequence		P	S	D	P	G	G	V	L	D	F	L	E	E	V	H	H	K	Q	E	S	I	M	D	A	G	P	V	V	V	H	C	S	A	G	I	G	R	T	G	T	F	I	V	I	D	I	L	I	D	I	I	R	E	K	G	V	D	C	D	I
Template Known Secondary structure			S																			S	T	T									S	S	S	S																					T	T	S
Template Predicted Secondary structure
Template SS confidence
		429	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.
		483	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	I	Q	K	T	I	Q	M	V	R	A	Q	R	S	G	M	V	Q	T	E	A	Q	Y	K	F	I	Y	V	A	I	A	Q	F	I	E	T	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	V	P	K	T	I	Q	M	V	R	S	Q	R	S	G	M	V	Q	T	E	A	Q	Y	R	S	I	Y	M	A	V	Q	H	Y	I	E	T	L
Template Known Secondary structure												T	T	S	T	T	S	S																			T
Template Predicted Secondary structure
Template SS confidence
		489	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.