Email l.a.kelley@imperial.ac.uk Description Q80TT8 Date Wed Jul 10 14:12:26 BST 2013 Unique Job ID 3c2b219eb02043cd

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c4kblA_ 100.0 28 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase arih1; PDBTitle: structure of hhari, a ring-ibr-ring ubiquitin ligase: autoinhibition2 of an ariadne-family e3 and insights into ligation mechanism 2 c2hyeC_ 100.0 21 PDB header:protein binding Chain: C: PDB Molecule:cullin-4a; PDBTitle: crystal structure of the ddb1-cul4a-rbx1-sv5v complex 3 c4a0lH_ 100.0 21 PDB header:ligase/dna-binding protein/dna Chain: H: PDB Molecule:cullin-4b; PDBTitle: structure of ddb1-ddb2-cul4b-rbx1 bound to a 12 bp abasic2 site containing dna-duplex 4 c1u6gA_ 100.0 22 PDB header:ligase Chain: A: PDB Molecule:cullin homolog 1; PDBTitle: crystal structure of the cand1-cul1-roc1 complex 5 c4k95G_ 100.0 24 PDB header:ligase Chain: G: PDB Molecule:e3 ubiquitin-protein ligase parkin; PDBTitle: crystal structure of parkin 6 c3dplC_ 99.9 18 PDB header:ligase Chain: C: PDB Molecule:cullin-5; PDBTitle: structural insights into nedd8 activation of cullin-ring2 ligases: conformational control of conjugation. 7 c1ldkB_ 99.9 21 PDB header:ligase Chain: B: PDB Molecule:cullin homolog; PDBTitle: structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin2 ligase complex 8 d1gqpa_ 99.9 23 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:APC10-like 9 c1gqpB_ 99.9 19 PDB header:cell cycle Chain: B: PDB Molecule:doc1/apc10; PDBTitle: apc10/doc1 subunit of s. cerevisiae 10 d1ldja3 99.8 24 Fold:Cullin homology domain Superfamily:Cullin homology domain Family:Cullin homology domain 11 d1jhja_ 99.7 26 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:APC10-like 12 c2m48A_ 99.7 24 PDB header:ligase Chain: A: PDB Molecule:sd01679p; PDBTitle: solution structure of ibr-ring2 tandem domain from parkin 13 d2hyec3 99.7 24 Fold:Cullin homology domain Superfamily:Cullin homology domain Family:Cullin homology domain 14 d1wd2a_ 99.5 40 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 15 d1wima_ 99.1 21 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 16 d2ct7a1 98.8 25 Fold:RING/U-box Superfamily:RING/U-box Family:IBR domain 17 c3o2pE_ 98.4 25 PDB header:ligase, cell cycle Chain: E: PDB Molecule:cell division control protein 53; PDBTitle: a dual e3 mechanism for rub1 ligation to cdc53: dcn1(p)-cdc53(whb) 18 d1ldja1 98.4 26 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:SCF ubiquitin ligase complex WHB domain 19 d1iuya_ 98.2 23 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:SCF ubiquitin ligase complex WHB domain 20 d2hyec1 98.0 27 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:SCF ubiquitin ligase complex WHB domain 21 c2j1aA_ not modelled 98.0 17 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronidase; PDBTitle: structure of cbm32 from clostridium perfringens beta-n-2 acetylhexosaminidase gh84c in complex with galactose 22 c2jmoA_ not modelled 97.9 21 PDB header:ligase Chain: A: PDB Molecule:parkin; PDBTitle: ibr domain of human parkin 23 d1w8oa2 not modelled 97.8 20 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Galactose-binding domain 24 c2kd7A_ not modelled 97.2 17 PDB header:cell adhesion Chain: A: PDB Molecule:putative chitobiase; PDBTitle: solution nmr structure of f5/8 type c-terminal domain of a2 putative chitobiase from bacteroides thetaiotaomicron.3 northeast structural genomics consortium target btr324b 25 c3eypB_ not modelled 96.7 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative alpha-l-fucosidase; PDBTitle: crystal structure of putative alpha-l-fucosidase from bacteroides2 thetaiotaomicron 26 c4a44A_ not modelled 96.7 14 PDB header:hydrolase Chain: A: PDB Molecule:alpha-n-acetylglucosaminidase family protein; PDBTitle: cpgh89cbm32-5, from clostridium perfringens, in complex with the tn2 antigen 27 d1tvga_ not modelled 96.6 15 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:APC10-like 28 d1e4ua_ not modelled 96.5 32 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 29 c2jdaA_ not modelled 96.4 11 PDB header:sugar-binding protein Chain: A: PDB Molecule:yecbm32; PDBTitle: structure of a pectin binding carbohydrate binding module2 determined in an monoclinic crystal form. 30 c4a42B_ not modelled 96.4 20 PDB header:hydrolase Chain: B: PDB Molecule:alpha-n-acetylglucosaminidase family protein; PDBTitle: cpgh89cbm32-6 produced by clostridium perfringens 31 c3htkC_ not modelled 96.2 24 PDB header:recombination/replication/ligase Chain: C: PDB Molecule:e3 sumo-protein ligase mms21; PDBTitle: crystal structure of mms21 and smc5 complex 32 c3hnmD_ not modelled 96.1 13 PDB header:structural genomics, unknown function Chain: D: PDB Molecule:putative chitobiase; PDBTitle: crystal structure of protein bt_411 (putative chitobiase,2 fragment 298-461) from bacteroides thetaiotaomicron,3 northeast structural genomics consortium target btr319d 33 c3l11A_ not modelled 96.1 19 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase rnf168; PDBTitle: crystal structure of the ring domain of rnf168 34 c2ct2A_ not modelled 95.6 29 PDB header:ligase Chain: A: PDB Molecule:tripartite motif protein 32; PDBTitle: solution structure of the ring domain of the tripartite2 motif protein 32 35 c3ztgA_ not modelled 95.6 21 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase rbbp6; PDBTitle: solution structure of the ring finger-like domain of2 retinoblastoma binding protein-6 (rbbp6) 36 c2vz1A_ not modelled 95.5 15 PDB header:oxidoreductase Chain: A: PDB Molecule:galactose oxidase; PDBTitle: premat-galactose oxidase 37 d1k3ia2 not modelled 95.3 15 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Galactose-binding domain 38 c2yc2A_ not modelled 95.3 16 PDB header:transport protein Chain: A: PDB Molecule:intraflagellar transport protein 25; PDBTitle: intraflagellar transport complex 25-27 from chlamydomonas 39 c2yu4A_ not modelled 95.2 14 PDB header:apoptosis Chain: A: PDB Molecule:e3 sumo-protein ligase nse2; PDBTitle: solution structure of the sp-ring domain in non-smc element2 2 homolog (mms21, s. cerevisiae) 40 c2csyA_ not modelled 95.2 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:zinc finger protein 183-like 1; PDBTitle: solution structure of the ring domain of the zinc finger2 protein 183-like 1 41 c3lrqB_ not modelled 94.9 27 PDB header:ligase Chain: B: PDB Molecule:e3 ubiquitin-protein ligase trim37; PDBTitle: crystal structure of the u-box domain of human ubiquitin-2 protein ligase (e3), northeast structural genomics3 consortium target hr4604d. 42 c4a6oB_ not modelled 94.9 17 PDB header:hydrolase Chain: B: PDB Molecule:alpha-n-acetylglucosaminidase family protein; PDBTitle: cpgh89cbm32-4, produced by clostridium perfringens, in2 complex with glcnac-alpha-1,4-galactose 43 c2d8tA_ not modelled 94.8 19 PDB header:metal binding protein Chain: A: PDB Molecule:ring finger protein 146; PDBTitle: solution structure of the ring domain of the human ring2 finger protein 146 44 c2ecwA_ not modelled 94.8 22 PDB header:apoptosis Chain: A: PDB Molecule:tripartite motif-containing protein 30; PDBTitle: solution structure of the zinc finger, c3hc4 type (ring2 finger) domain tripartite motif protein 30 45 c4epoL_ not modelled 94.7 29 PDB header:protein binding/ligase Chain: L: PDB Molecule:e3 ubiquitin-protein ligase rnf8; PDBTitle: crystal structure of rnf8 bound to the ubc13/mms2 heterodimer 46 d2hyec2 not modelled 94.6 15 Fold:alpha-alpha superhelix Superfamily:Cullin repeat-like Family:Cullin repeat 47 c2yurA_ not modelled 94.6 24 PDB header:protein binding Chain: A: PDB Molecule:retinoblastoma-binding protein 6; PDBTitle: solution structure of the ring finger of human2 retinoblastoma-binding protein 6 48 c2berA_ not modelled 94.5 20 PDB header:hydrolase Chain: A: PDB Molecule:bacterial sialidase; PDBTitle: y370g active site mutant of the sialidase from2 micromonospora viridifaciens in complex with beta-neu5ac3 (sialic acid). 49 c2v72A_ not modelled 94.3 12 PDB header:sugar-binding protein Chain: A: PDB Molecule:exo-alpha-sialidase; PDBTitle: the structure of the family 32 cbm from c. perfringens nanj2 in complex with galactose 50 c2egpA_ not modelled 94.3 25 PDB header:antiviral protein Chain: A: PDB Molecule:tripartite motif-containing protein 34; PDBTitle: solution structure of the ring-finger domain from human2 tripartite motif protein 34 51 c2j22A_ not modelled 94.2 14 PDB header:carbohydrate-binding protein Chain: A: PDB Molecule:fucolectin-related protein; PDBTitle: structure of a streptococcus pneumoniae fucose binding2 module, spx-3 52 c2cklB_ not modelled 94.2 26 PDB header:transcription Chain: B: PDB Molecule:ubiquitin ligase protein ring2; PDBTitle: ring1b-bmi1 e3 catalytic domain structure 53 c2kizA_ not modelled 94.2 25 PDB header:metal binding protein Chain: A: PDB Molecule:e3 ubiquitin-protein ligase arkadia; PDBTitle: solution structure of arkadia ring-h2 finger domain 54 c2y43B_ not modelled 94.1 23 PDB header:ligase Chain: B: PDB Molecule:e3 ubiquitin-protein ligase rad18; PDBTitle: rad18 ubiquitin ligase ring domain structure 55 c2ecvA_ not modelled 94.0 26 PDB header:ligase Chain: A: PDB Molecule:tripartite motif-containing protein 5; PDBTitle: solution structure of the zinc finger, c3hc4 type (ring2 finger) domain of tripartite motif-containing protein 5 56 c2ep4A_ not modelled 93.8 29 PDB header:protein binding Chain: A: PDB Molecule:ring finger protein 24; PDBTitle: solution structure of ring finger from human ring finger2 protein 24 57 c2l0bA_ not modelled 93.8 23 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase praja-1; PDBTitle: solution nmr structure of zinc finger domain of e3 ubiquitin-protein2 ligase praja-1 from homo sapiens, northeast structural genomics3 consortium (nesg) target hr4710b 58 c2ectA_ not modelled 93.7 29 PDB header:metal binding protein Chain: A: PDB Molecule:ring finger protein 126; PDBTitle: solution structure of the zinc finger, c3hc4 type (ring2 finger) domain of ring finger protein 126 59 d1jm7a_ not modelled 93.6 20 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 60 c2yslA_ not modelled 93.6 25 PDB header:protein binding Chain: A: PDB Molecule:tripartite motif-containing protein 31; PDBTitle: solution structure of the ring domain (1-66) from2 tripartite motif-containing protein 31 61 c2ecmA_ not modelled 93.3 25 PDB header:metal binding protein Chain: A: PDB Molecule:ring finger and chy zinc finger domain- PDBTitle: solution structure of the ring domain of the ring finger2 and chy zinc finger domain-containing protein 1 from mus3 musculus 62 d1rmda2 not modelled 93.3 20 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 63 c2w1sB_ not modelled 93.0 12 PDB header:hydrolase Chain: B: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: unique ligand binding specificity of a family 322 carbohydrate-binding module from the mu toxin produced by3 clostridium perfringens 64 c3l6yA_ 92.6 15 PDB header:cell adhesion Chain: A: PDB Molecule:catenin delta-1; PDBTitle: crystal structure of p120 catenin in complex with e-cadherin 65 c2cklA_ not modelled 92.6 30 PDB header:transcription Chain: A: PDB Molecule:polycomb group ring finger protein 4; PDBTitle: ring1b-bmi1 e3 catalytic domain structure 66 d1ldja2 not modelled 92.6 18 Fold:alpha-alpha superhelix Superfamily:Cullin repeat-like Family:Cullin repeat 67 c2ecjA_ not modelled 92.4 21 PDB header:metal binding protein Chain: A: PDB Molecule:tripartite motif-containing protein 39; PDBTitle: solution structure of the ring domain of the human2 tripartite motif-containing protein 39 68 c2j1sB_ not modelled 92.4 12 PDB header:carbohydrate-binding protein Chain: B: PDB Molecule:fucolectin-related protein; PDBTitle: structure of a streptococcus pneumoniae fucose binding2 module in complex with fucose 69 d1chca_ not modelled 92.4 31 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 70 c2ea6A_ not modelled 92.3 30 PDB header:transcription Chain: A: PDB Molecule:ring finger protein 4; PDBTitle: solution structure of the ring domain of the human ring2 finger protein 4 71 d1v87a_ not modelled 92.2 24 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 72 c1z6uA_ not modelled 92.2 19 PDB header:ligase Chain: A: PDB Molecule:np95-like ring finger protein isoform b; PDBTitle: np95-like ring finger protein isoform b [homo sapiens] 73 c2djbA_ not modelled 92.0 38 PDB header:gene regulation Chain: A: PDB Molecule:polycomb group ring finger protein 6; PDBTitle: solution structure of the ring domain of the human polycomb2 group ring finger protein 6 74 d1jm7b_ not modelled 91.9 21 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 75 c1x4jA_ not modelled 91.9 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:ring finger protein 38; PDBTitle: solution structure of ring finger in ring finger protein 38 76 c2eciA_ not modelled 91.8 24 PDB header:metal binding protein Chain: A: PDB Molecule:tnf receptor-associated factor 6; PDBTitle: solution structure of the ring domain of the human tnf2 receptor-associated factor 6 protein 77 c2ecyA_ not modelled 91.7 22 PDB header:apoptosis Chain: A: PDB Molecule:tnf receptor-associated factor 3; PDBTitle: solution structure of the zinc finger, c3hc4 type (ring2 finger)" domain of tnf receptor-associated factor 3 78 c3fl2A_ not modelled 91.5 22 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase uhrf1; PDBTitle: crystal structure of the ring domain of the e3 ubiquitin-2 protein ligase uhrf1 79 c2h0dB_ not modelled 91.5 21 PDB header:metal binding protein/ligase Chain: B: PDB Molecule:ubiquitin ligase protein ring2; PDBTitle: structure of a bmi-1-ring1b polycomb group ubiquitin ligase complex 80 c3knvA_ not modelled 91.3 19 PDB header:signaling protein Chain: A: PDB Molecule:tnf receptor-associated factor 2; PDBTitle: crystal structure of the ring and first zinc finger domains2 of traf2 81 c2f42A_ not modelled 90.9 12 PDB header:chaperone Chain: A: PDB Molecule:stip1 homology and u-box containing protein 1; PDBTitle: dimerization and u-box domains of zebrafish c-terminal of hsp702 interacting protein 82 c3mo4B_ not modelled 90.8 25 PDB header:hydrolase Chain: B: PDB Molecule:alpha-1,3/4-fucosidase; PDBTitle: the crystal structure of an alpha-(1-3,4)-fucosidase from2 bifidobacterium longum subsp. infantis atcc 15697 83 c2ls6A_ not modelled 90.8 13 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: solution nmr structure of a non-canonical galactose-binding cbm32 from2 clostridium perfringens 84 c3hcsA_ not modelled 90.5 26 PDB header:signaling protein Chain: A: PDB Molecule:tnf receptor-associated factor 6; PDBTitle: crystal structure of the n-terminal domain of traf6 85 c2y9iB_ not modelled 90.5 15 PDB header:sugar binding protein Chain: B: PDB Molecule:carbohydrate binding family 6; PDBTitle: cbm62 in complex with xyloglucan oligosaccharide 86 d1g25a_ not modelled 90.4 28 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 87 c2y38A_ not modelled 89.7 23 PDB header:structural protein Chain: A: PDB Molecule:laminin subunit alpha-5; PDBTitle: laminin alpha5 chain n-terminal fragment 88 c1rmdA_ not modelled 89.6 21 PDB header:dna-binding protein Chain: A: PDB Molecule:rag1; PDBTitle: rag1 dimerization domain 89 c2d8sA_ not modelled 89.5 19 PDB header:metal binding protein Chain: A: PDB Molecule:cellular modulator of immune recognition; PDBTitle: solution structure of the ring domain of the human cellular2 modulator of immune recognition protein 90 d2c2vv1 not modelled 89.4 13 Fold:RING/U-box Superfamily:RING/U-box Family:U-box 91 d1ur6b_ not modelled 89.3 33 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 92 d1fbva4 not modelled 88.6 25 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 93 c2ecnA_ not modelled 88.2 27 PDB header:metal binding protein Chain: A: PDB Molecule:ring finger protein 141; PDBTitle: solution structure of the ring domain of the human ring2 finger protein 141 94 d1v92a_ not modelled 86.7 23 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:TAP-C domain-like 95 c2xeuA_ not modelled 86.6 33 PDB header:transcription Chain: A: PDB Molecule:ring finger protein 4; PDBTitle: ring domain 96 d3dplr1 not modelled 85.6 24 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 97 c2jrjA_ not modelled 85.1 24 PDB header:ligase Chain: A: PDB Molecule:ring finger and chy zinc finger domain PDBTitle: solution structure of the human pirh2 ring-h2 domain.2 northeast structural genomics consortium target ht2b 98 c3nw0A_ not modelled 85.0 14 PDB header:metal binding protein Chain: A: PDB Molecule:non-structural maintenance of chromosomes element 1 PDBTitle: crystal structure of mageg1 and nse1 complex 99 c2jmdA_ not modelled 83.6 26 PDB header:ligase Chain: A: PDB Molecule:tnf receptor-associated factor 6; PDBTitle: solution structure of the ring domain of human traf6 100 c3hctA_ not modelled 83.6 21 PDB header:signaling protein/ligase Chain: A: PDB Molecule:tnf receptor-associated factor 6; PDBTitle: crystal structure of traf6 in complex with ubc13 in the p12 space group 101 d1bora_ not modelled 83.0 30 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 102 d1vyxa_ not modelled 82.8 27 Fold:RING/U-box Superfamily:RING/U-box Family:Variant RING domain 103 d1t1ha_ not modelled 82.3 16 Fold:RING/U-box Superfamily:RING/U-box Family:U-box 104 c3le0A_ not modelled 82.1 10 PDB header:blood clotting Chain: A: PDB Molecule:platelet aggregation factor sm-hpaf; PDBTitle: lectin domain of lectinolysin complexed with glycerol 105 c2wzkA_ not modelled 80.9 23 PDB header:protein binding Chain: A: PDB Molecule:cullin-5; PDBTitle: structure of the cul5 n-terminal domain at 2.05a resolution. 106 d1xm9a1 not modelled 80.8 12 Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:Plakophilin 1 helical region 107 d1iyma_ not modelled 80.5 32 Fold:RING/U-box Superfamily:RING/U-box Family:RING finger domain, C3HC4 108 c1dgsB_ not modelled 79.6 27 PDB header:ligase Chain: B: PDB Molecule:dna ligase; PDBTitle: crystal structure of nad+-dependent dna ligase from t.2 filiformis 109 d2c2la2 not modelled 79.4 10 Fold:RING/U-box Superfamily:RING/U-box Family:U-box 110 c2ct0A_ not modelled 78.9 18 PDB header:gene regulation Chain: A: PDB Molecule:non-smc element 1 homolog; PDBTitle: solution structure of the ring domain of the non-smc2 element 1 protein 111 c2kreA_ not modelled 78.8 17 PDB header:protein binding Chain: A: PDB Molecule:ubiquitin conjugation factor e4 b; PDBTitle: solution structure of e4b/ufd2a u-box domain 112 c2z6gA_ not modelled 78.6 14 PDB header:cell adhesion Chain: A: PDB Molecule:b-catenin; PDBTitle: crystal structure of a full-length zebrafish beta-catenin 113 c4aqsA_ not modelled 78.2 21 PDB header:cell adhesion Chain: A: PDB Molecule:laminin subunit beta-1; PDBTitle: laminin beta1 ln-le1-4 structure 114 d1zbdb_ not modelled 77.6 16 Fold:FYVE/PHD zinc finger Superfamily:FYVE/PHD zinc finger Family:FYVE, a phosphatidylinositol-3-phosphate binding domain 115 c3zyiB_ not modelled 76.4 26 PDB header:cell adhesion Chain: B: PDB Molecule:netrin-g2; PDBTitle: netring2 in complex with ngl2 116 c3t7uA_ not modelled 75.2 15 PDB header:cell adhesion Chain: A: PDB Molecule:adenomatous polyposis coli protein; PDBTitle: a new crytal structure of apc-arm 117 c4ap4A_ not modelled 74.7 26 PDB header:ligase/signalling protein Chain: A: PDB Molecule:e3 ubiquitin ligase rnf4; PDBTitle: rnf4 - ubch5a - ubiquitin heterotrimeric complex 118 c2eclA_ not modelled 74.0 22 PDB header:metal binding protein Chain: A: PDB Molecule:ring-box protein 2; PDBTitle: solution structure of the ring domain of the human ring-box2 protein 2 119 c2hdpB_ not modelled 73.4 12 PDB header:ligase Chain: B: PDB Molecule:ubiquitin-protein ligase e3 mdm2; PDBTitle: solution structure of hdm2 ring finger domain 120 c3tbdA_ not modelled 72.8 26 PDB header:cell adhesion Chain: A: PDB Molecule:netrin-g2; PDBTitle: crystal structure of domain vi and le1 of human netrin-g2