Job Description Q80TT8 Confidence 99.94% Date Wed Jul 10 14:12:26 BST 2013 Rank 6 Aligned Residues 346 % Identity 18% Template c3dplC_ PDB info PDB header:ligase Chain: C: PDB Molecule:cullin-5; PDBTitle: structural insights into nedd8 activation of cullin-ring2 ligases: conformational control of conjugation. Resolution 2.60 Å Model Dimensions (Å) X:60.910 Y:79.626 Z:56.994

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		882	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	H	I	S	E	Q	F	A	R	H	I	D	Q	Q	I	H	G	G	L	L	G	G	A	A	G	V	G	M	L	G	R	L	Q	R	H	L	E	P	I	M	V	L	S	G	L	E	L	A	T	T	F	E	H	F	Y	Q	H	Y	M	A
Query Conservation
Alig confidence																																						.	.
Template Conservation																																						.	.
Template Sequence		S	K	C	P	E	E	L	A	N	Y	C	D	M	L	L	R	K	T	P	L	S	K	K	L	T	S	E	E	I	E	A	K	L	K	E	V	.	.	L	K	K	L	K	Y	V	Q	N	K	D	V	F	M	R	Y	H	K	A	H	L	T
Template Known Secondary structure				S													B	S	S					T	S													.	.		G	G	G	G	G		S
Template Predicted Secondary structure																																						.	.
Template SS confidence
		402	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.			.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.
		942	.	.	.	.	.	.	.			950	.	.	.	.	.	.	.	.	.	960						.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.
Predicted Secondary structure										.	.												.	.	.	.	.
Query SS confidence										.	.												.	.	.	.	.
Query Sequence		D	R	L	L	S	L	G	S	.	.	S	W	L	E	G	A	V	L	E	Q	I	.	.	.	.	.	G	P	C	F	P	N	R	L	P	Q	L	M	L	Q	S	L	H	T	S	E	E	L	Q	H	R	F	H	L	F	Q	L	Q	Q	L
Query Conservation										.	.												.	.	.	.	.
Alig confidence										.	.												.	.	.	.	.									.																							.	.	.
Template Conservation																																				.																							.	.	.
Template Sequence		R	R	L	I	L	D	I	S	A	D	S	E	I	E	E	N	M	V	E	W	L	R	E	V	G	M	P	A	D	Y	V	N	K	L	.	A	R	M	F	Q	D	I	K	V	S	E	D	L	N	Q	A	F	K	E	M	H	K	.	.	.
Template Known Secondary structure						T	T		B	S															T	T										.																					T		.	.	.
Template Predicted Secondary structure																																				.																							.	.	.
Template SS confidence
		460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.		.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.
		995	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	R	Q	L	L	E	Q	G	D	Q	E	E	W	R	P	E	K	V	E	E	D	D	E	G	Q	E	T	G	R	E	L	F	T	D	P	G	P	A	I	S	V	L	V	L	S	P	R	C	W	P	V	S	P	L	C	Y	L	H	H	P
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																								.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																								.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	N	A	L	P	A	D	S	V	N	I	K	I	L	N	A	G	A	W	S	R	S	S	.	.	.	.	E	K	V
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.						G	G	G															S	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																								.	.	.	.
Template SS confidence
																																516	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.					.	540	.
		1055	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.	.	.	.	.	.	.	.	1090	.	.	.	.		.	.	.	.	.	1100	.	.					.	.	.	.	.	.	.
Predicted Secondary structure																																										.									.	.	.	.
Query SS confidence																																										.									.	.	.	.
Query Sequence		R	K	H	L	Q	A	E	L	C	D	A	L	E	R	F	S	S	F	Y	S	H	S	Q	N	C	P	V	L	D	I	G	P	H	R	R	L	Q	W	T	W	.	L	G	R	A	E	L	Q	L	.	.	.	.	G	D	Q	T	L	H	V
Query Conservation																																										.									.	.	.	.
Alig confidence																										.	.	.	.	.	.	.	.									.									.	.	.	.
Template Conservation																										.	.	.	.	.	.	.	.
Template Sequence		F	V	S	L	P	T	E	L	E	D	L	I	P	E	V	E	E	F	Y	K	K	N	H	S	.	.	.	.	.	.	.	.	G	R	K	L	H	W	H	H	L	M	S	N	G	I	I	T	F	K	N	E	V	G	Q	Y	D	L	E	V
Template Known Secondary structure											T	T										T	T	S	S	.	.	.	.	.	.	.	.	S							G	G	G										S	S
Template Predicted Secondary structure																										.	.	.	.	.	.	.	.
Template SS confidence
		544	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.									.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.
		1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.			.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.										.	.	.
Predicted Secondary structure																	.	.																																.	.	.	.	.	.	.	.	.
Query SS confidence																	.	.																																.	.	.	.	.	.	.	.	.
Query Sequence		S	L	N	T	V	Q	M	W	L	L	F	N	Q	S	E	.	.	E	V	S	V	E	T	L	L	R	N	S	D	L	S	P	E	L	L	H	Q	A	L	L	P	L	T	S	D	N	G	P	.	.	.	.	.	.	.	.	.	L	T	L
Query Conservation																	.	.																																.	.	.	.	.	.	.	.	.
Alig confidence																	.	.																																.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		T	T	F	Q	L	A	V	L	F	A	W	N	Q	R	P	R	E	K	I	S	F	E	N	L	K	L	A	T	E	L	P	D	A	E	L	R	R	T	L	W	S	L	V	A	F	P	K	L	K	R	Q	V	L	L	Y	E	P	Q	V	N
Template Known Secondary structure										G	G	G	T	T		T	T																														T	T		S	S		S				S	S			S
Template Predicted Secondary structure
Template SS confidence
		596	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.
		1159	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180									.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200	.	.	.	.	.	.	.	.	.	1210
Predicted Secondary structure																								.	.	.	.	.	.	.	.
Query SS confidence																								.	.	.	.	.	.	.	.
Query Sequence		E	E	T	Q	D	Y	P	Q	G	G	V	L	R	L	R	E	P	R	S	Q	T	H	.	.	.	.	.	.	.	.	E	E	F	L	W	L	I	P	P	Q	T	Y	L	S	V	E	K	D	E	G	R	T	L	E	Q	K	R	N	L	L
Query Conservation																								.	.	.	.	.	.	.	.
Alig confidence																								.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		S	P	K	D	F	T	E	G	T	L	F	S	V	N	Q	E	F	S	L	I	K	N	A	K	V	Q	K	R	G	K	I	N	L	I	G	R	L	Q	L	T	T	E	R	M	R	E	E	E	N	E	G	I	V	Q	L	R	I	L	R	T
Template Known Secondary structure		S	G	G	G			T	T							T	T					S	S	S	S			S								T	T	T	T	S
Template Predicted Secondary structure
Template SS confidence
		656	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.
		1211	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260	.	.	.	.	.	.	.	.	.	1270
Predicted Secondary structure
Query SS confidence
Query Sequence		S	C	L	L	V	R	I	L	K	A	H	R	E	K	G	L	H	I	D	Q	L	V	C	L	V	L	E	A	W	Q	K	G	P	D	P	P	G	R	L	G	N	A	A	A	V	G	V	A	C	S	S	T	D	V	L	S	C	I	L	H
Query Conservation
Alig confidence															.	.																		.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation															.	.																		.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		Q	E	A	I	I	Q	I	M	K	M	R	K	K	.	.	I	S	N	A	Q	L	Q	T	E	L	V	E	I	L	K	N	M	.	.	.	.	.	.	.	.	.	.	.	.	.	.	F	L	P	Q	K	K	M	I	K	E	Q	I	E	W
Template Known Secondary structure										T	T	S	S		.	.														T	T	T	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure															.	.																		.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		716	.	.	.	720	.	.	.	.	.	.	.	.			.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.															.	.	.	.	750	.	.	.	.	.	.	.	.	.
		1271	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	L	G	Q	G	Y	V	E	R	R	D	D	R	P	Q	V	L	M	Y	A	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	I	E	H	K	Y	I	R	R	D	E	S	D	I	N	T	F	I	Y	M	A
Template Known Secondary structure					T	T	S					T	T
Template Predicted Secondary structure
Template SS confidence
		760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780