Job Description Q80TT8 Confidence 100.00% Date Wed Jul 10 14:12:26 BST 2013 Rank 2 Aligned Residues 515 % Identity 21% Template c2hyeC_ PDB info PDB header:protein binding Chain: C: PDB Molecule:cullin-4a; PDBTitle: crystal structure of the ddb1-cul4a-rbx1-sv5v complex Resolution 3.10 Å Model Dimensions (Å) X:122.284 Y:83.229 Z:53.704

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		642	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	F	R	E	Q	L	C	R	R	T	C	L	F	Y	T	I	R	A	Q	A	W	S	R	D	I	A	E	D	R	Q	R	L	L	Q	L	Y	P	R	L	N	R	V	L	R	H	E	Q	N	F	A	D	R	F	L	P	D	D	E	A	A
Query Conservation
Alig confidence																										.	.	.	.	.																													.
Template Conservation																										.	.	.	.	.																													.
Template Sequence		S	F	E	L	K	F	L	E	E	T	N	C	L	Y	A	A	E	G	Q	R	L	M	Q	E	.	.	.	.	.	R	E	V	P	E	Y	L	N	H	V	S	K	R	L	E	E	E	G	D	R	V	I	T	Y	L	D	H	S	.	T	Q
Template Known Secondary structure			T																							.	.	.	.	.	S																T					T	T	T	S		T	T	.	T
Template Predicted Secondary structure																										.	.	.	.	.																													.
Template SS confidence
		230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.						.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.		.	.
		702	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	A	L	G	K	T	C	W	E	A	L	V	S	P	L	V	Q	N	I	T	S	P	D	A	G	G	V	S	S	L	G	W	L	L	D	Q	Y	L	E	H	R	E	S	T	R	S	R	Q	G	P	A	A	S	F	A	S	Q	V	R	R
Query Conservation
Alig confidence																									.	.	.	.	.	.	.	.	.	.													.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																									.	.	.	.	.	.	.	.	.	.													.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		K	P	L	I	A	C	V	E	K	Q	L	L	G	E	H	L	T	A	I	L	Q	K	G	.	.	.	.	.	.	.	.	.	.	L	D	H	L	L	D	E	N	R	V	P	D	.	.	.	.	.	.	.	.	.	.	.	.	L	A	Q
Template Known Secondary structure													T	T	T		S						T	T	.	.	.	.	.	.	.	.	.	.						T	T	T					.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																									.	.	.	.	.	.	.	.	.	.													.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		284	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.											.	.	.	310	.	.	.	.	.	.	.	.													.	320	.
		762	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	C	H	L	L	V	H	V	E	A	P	P	G	P	S	P	E	P	S	S	Q	P	L	S	K	N	S	K	G	Q	D	G	S	P	T	P	A	P	T	P	V	C	P	S	T	S	L	R	N	L	T	Q	C	W	L	S	V	V	Q	G
Query Conservation
Alig confidence											.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation											.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		M	Y	Q	L	F	S	R	V	R	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	G	G	Q	Q	A	L	L	Q	H	W	S	E	Y	I	K	T
Template Known Secondary structure									S	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T
Template Predicted Secondary structure											.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		322	.	.	.	.	.	.	.	330																																				.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.
		822	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	V	S	R	F	L	A	A	A	W	R	A	S	D	F	V	P	R	Y	C	S	L	Y	Q	R	L	Q	S	A	G	S	E	L	F	G	P	R	A	A	F	T	L	A	L	R	S	G	F	S	G	A	L	L	Q	Q	S	F	L	T	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		F	G	T	A	I	V	I	N	P	E	K	D	K	D	M	V	Q	D	L	L	D	F	K	D	K	V	D	H	V	I	E	V	C	F	Q	K	N	E	R	F	V	N	L	M	K	E	S	F	E	T	F	I	N	K	R	P	N	K	P	A
Template Known Secondary structure								S		G	G	G	T	T	T																		T	T	T	T	T																	T	T	S		S
Template Predicted Secondary structure
Template SS confidence
		347	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.
		882	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	H	I	S	E	Q	F	A	R	H	I	D	Q	Q	I	H	G	G	L	L	G	G	A	A	G	V	G	M	L	G	R	L	Q	R	H	L	E	P	I	M	V	L	S	G	L	E	L	A	T	T	F	E	H	F	Y	Q	H	Y	M	A
Query Conservation
Alig confidence		.	.	.	.													.																				.	.	.
Template Conservation		.	.	.	.													.																				.	.	.
Template Sequence		.	.	.	.	E	L	I	A	K	H	V	D	S	K	L	R	.	A	G	N	K	E	A	T	D	E	E	L	E	R	T	L	D	K	I	M	.	.	.	I	L	F	R	F	I	H	G	K	D	V	F	E	A	F	Y	K	K	D	L	A
Template Known Secondary structure		.	.	.	.												S	.	S		G	G	G			S	T	T										.	.	.				T	T		S
Template Predicted Secondary structure		.	.	.	.													.																				.	.	.
Template SS confidence
						407	.	.	410	.	.	.	.	.	.	.	.		.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.				.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.
		942	.	.	.	.	.	.	.	950	.			.	.	.	.	.	.	.	.	960					.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.
Predicted Secondary structure												.	.										.	.	.	.
Query SS confidence												.	.										.	.	.	.
Query Sequence		D	R	L	L	S	L	G	S	S	W	.	.	L	E	G	A	V	L	E	Q	I	.	.	.	.	G	P	C	F	P	N	R	L	P	Q	L	M	L	Q	S	L	H	T	S	E	E	L	Q	H	R	F	H	L	F	Q	L	Q	Q	L	D
Query Conservation												.	.										.	.	.	.
Alig confidence												.	.										.	.	.	.									.																									.	.
Template Conservation																																			.																									.	.
Template Sequence		K	R	L	L	V	G	K	S	A	S	V	D	A	E	K	S	M	L	S	K	L	K	H	E	C	G	A	A	F	T	S	K	L	.	E	G	M	F	K	D	M	E	L	S	K	D	I	M	V	H	F	K	Q	H	M	Q	N	Q	.	.
Template Known Secondary structure						S	S			S														T	T	T		T	T	T	T				.																							T	T	.	.
Template Predicted Secondary structure																																			.																									.	.
Template SS confidence
		459	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.		.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.
		996	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	Q	L	L	E	Q	G	D	Q	E	E	W	R	P	E	K	V	E	E	D	D	E	G	Q	E	T	G	R	E	L	F	T	D	P	G	P	A	I	S	V	L	V	L	S	P	R	C	W	P	V	S	P	L	C	Y	L	H	H	P	R
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																							.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																							.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	D	S	G	P	I	D	L	T	V	N	I	L	T	M	G	Y	W	P	T	Y	T	.	.	.	.	.	P	M	E
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.															T	T	T	S					.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																							.	.	.	.	.
Template SS confidence
																																516	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.						.	.	540
		1056	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.	.	.	.	.	.	.	.	1090	.	.	.	.		.	.	.	.	.	1100	.	.					.	.	.	.	.	.	.	1110
Predicted Secondary structure																																									.									.	.	.	.
Query SS confidence																																									.									.	.	.	.
Query Sequence		K	H	L	Q	A	E	L	C	D	A	L	E	R	F	S	S	F	Y	S	H	S	Q	N	C	P	V	L	D	I	G	P	H	R	R	L	Q	W	T	W	.	L	G	R	A	E	L	Q	L	.	.	.	.	G	D	Q	T	L	H	V	S
Query Conservation																																									.									.	.	.	.
Alig confidence																									.	.	.	.	.	.	.	.									.									.	.	.	.
Template Conservation																									.	.	.	.	.	.	.	.
Template Sequence		V	H	L	T	P	E	M	I	K	L	Q	E	V	F	K	A	F	Y	L	G	K	H	S	.	.	.	.	.	.	.	.	G	R	K	L	Q	W	Q	T	T	L	G	H	A	V	L	K	A	E	F	K	E	G	K	K	E	F	Q	V	S
Template Known Secondary structure																					T	T	S		.	.	.	.	.	.	.	.	S							G	G	G										S	S
Template Predicted Secondary structure																									.	.	.	.	.	.	.	.
Template SS confidence
		541	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.									.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.
		1111	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.			.	1160	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																		.	.
Query SS confidence																																																		.	.
Query Sequence		L	N	T	V	Q	M	W	L	L	F	N	Q	S	E	E	V	S	V	E	T	L	L	R	N	S	D	L	S	P	E	L	L	H	Q	A	L	L	P	L	T	S	D	N	G	P	L	T	L	.	.	E	E	T	Q	D	Y	P	Q	G	G
Query Conservation																																																		.	.
Alig confidence																																																		.	.
Template Conservation
Template Sequence		L	F	Q	T	L	V	L	L	M	F	N	E	G	D	G	F	S	F	E	E	I	K	M	A	T	G	I	E	D	S	E	L	R	R	T	L	Q	S	L	A	C	G	K	A	R	V	L	I	K	S	P	K	G	K	E	V	E	D	G	D
Template Known Secondary structure											T	T	S													T													T	T	T	T	T	T	T		S				T	T		S	S	S			S	S
Template Predicted Secondary structure
Template SS confidence
		593	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.
		1169	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.			.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.
Predicted Secondary structure																	.	.
Query SS confidence																	.	.
Query Sequence		V	L	R	L	R	E	P	R	S	Q	T	H	E	E	F	.	.	L	W	L	I	P	P	Q	T	Y	L	S	V	E	K	D	E	G	R	T	L	E	Q	K	R	N	L	L	S	C	L	L	V	R	I	L	K	A	H	R	E	K	G	L
Query Conservation																	.	.
Alig confidence																	.	.																																									.	.
Template Conservation																																																											.	.
Template Sequence		K	F	I	F	N	G	E	F	K	H	K	L	F	R	I	K	I	N	Q	I	Q	M	K	E	T	V	E	E	Q	V	S	T	T	E	R	V	F	Q	D	R	Q	Y	Q	I	D	A	A	I	V	R	I	M	K	M	R	K	T	.	.	L
Template Known Secondary structure												S		S	S				G	G	G	G	G																																	S	S		.	.
Template Predicted Secondary structure																																																											.	.
Template SS confidence
		653	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.			710
		1227	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	I	D	Q	L	V	C	L	V	L	E	A	W	Q	K	G	P	D	P	P	G	R	L	G	N	A	A	A	V	G	V	A	C	S	S	T	D	V	L	S	C	I	L	H	L	L	G	Q	G	Y	V	E	R	R	D	D	R	P	Q	V
Query Conservation
Alig confidence																		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		G	H	N	L	L	V	S	E	L	Y	N	Q	L	K	F	P	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	V	K	P	G	D	L	K	K	R	I	E	S	L	I	D	R	D	Y	M	E	R	D	K	D	N	P	N	Q
Template Known Secondary structure			T											S	S	S		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																T	T	S		B			S	S		T	T
Template Predicted Secondary structure																		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		711	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.																	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.
		1287	.	.	1290	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	M	Y	A	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	H	Y	V	A
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		755	.	.	.	.