|   |   |
220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
R | I | N | A | A | E | I | E | S | R | V | R | E | L | S | K | L | A | E | T | T | D | K | V | K | Q | G | F | W | E | E | F | E | T | L | Q | Q | Q | E | C | K | L | L | Y | S | R | K | E | G | Q | R | Q | E | N | K | N | K | N | R | Y |
| Query Conservation |   |
  |
|   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |
|
|   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |
|   |   |
|
|
|
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . |   |   |   |   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|
|
|
| Template Sequence |   |
A | I | P | V | K | Q | F | V | K | H | I | G | E | L | Y | S | N | N | Q | . |
. |
. |
. |
. |
. |
H | G | F | S | E | D | F | E | E | V | Q | R | C | T | A | D | M | N | I | T | A | E | H | S | N | H | P | E | N | K | H | K | N | R | Y |
| Template Known Secondary structure |   |
|  |  | G | G | G |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  | T | T | G | G | G |
|
|
|
| T | T | T | T | S | G | G | G | G | G | G |
| S | S |
| Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |
|
|  |  |  |  |
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
827 | . | . | 830 | . | . | . | . | . | . | . | . | . | 840 | . | . | . | . | . | |
|
|
|
|
|
. | . | . | . | 850 | . | . | . | . | . | . | . | . | . | 860 | . | . | . | . | . | . | . | . | . | 870 | . | . | . | . | . | . | . | . | . | 880 |
|   |
|   |   |
280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
K | N | I | L | P | F | D | H | T | R | V | V | L | H | D | G | D | P | N | E | P | V | S | D | Y | I | N | A | N | I | I | M | P | E | F | E | T | K | C | N | N | S | K | P | K | K | S | Y | I | A | T | Q | G | C | L | Q | N | T | V | N |
| Query Conservation |   |
  |
|
|
|
|
|
|   |
|
|
|   |
|   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|   |
|
|   |   |
|
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|   |   |   |
|   |
|
|
|   |
|   | . | . | . | . |   |   |   |   |   |
|
|
|
|
|
|   |
| . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |
|
|   |
|
|   |
|   |   |   |
|   |   |
| Template Sequence |   |
I | N | I | L | A | Y | D | H | S | R | V | K | L | R | . |
. |
. |
. |
P | L | P | H | S | D | Y | I | N | A | N | Y | V | . |
. |
. |
. |
. |
. |
. |
. |
D | G | Y | N | K | A | K | A | Y | I | A | T | Q | G | P | L | K | S | T | F | E |
| Template Known Secondary structure |   |
T | T |
|
|
|
| T | T | T |  |  |  |
|
| . | . | . | . |
|
|
|
| T | T |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . |  |  | T | T |  |  |  |  |  |  |  |  |
|
|
|
| G | G | G |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |
| . | . | . | . |
|
|
|
|
|
|  |  |  |  |  |  |
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
881 | . | . | . | . | . | . | . | . | 890 | . | . | . | . | |
|
|
|
. | . | . | . | . | 900 | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
. | . | 910 | . | . | . | . | . | . | . | . | . | 920 | . | . | . | . | . | . | . | . |
|   |
|   |   |
340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
D | F | W | R | M | V | F | Q | E | N | S | R | V | I | V | M | T | T | K | E | V | E | R | G | K | S | K | C | V | K | Y | W | P | D | E | Y | A | L | K | E | Y | G | V | M | R | V | R | N | V | K | E | S | A | A | H | D | Y | T | L | R |
| Query Conservation |   |
|
|
|   |
|
|
|
|   |   |
|   |   |
|
|
|
|
|   |   |   |
|   |   |   |   |
|
|   |   |
|
|
|   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|
|   |
|
|   |   |   |   |   |   |   |
|
|
|
|   |   |   |   |
|   |   |   |   |
|
|   |   |
|
|
|   |   | . |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
| Template Sequence |   |
D | F | W | R | M | I | W | E | Q | N | T | G | I | I | V | M | I | T | N | L | V | E | K | G | R | R | K | C | D | Q | Y | W | P | T | E | . |
N | S | E | E | Y | G | N | I | I | V | T | L | K | S | T | K | I | H | A | C | Y | T | V | R |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  | T |
|
|  |  |  |  |
| S |
| S |  |  | T | T |  |  |
|
|
|
|
| S |
| S | S | . | S |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |
| S | S |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
934 | . | . | . | . | . | 940 | . | . | . | . | . | . | . | . | . | 950 | . | . | . | . | . | . | . | . | . | 960 | . | . | . | . | . | . | . | . | |
. | 970 | . | . | . | . | . | . | . | . | . | 980 | . | . | . | . | . | . | . | . | . | 990 | . | . |
|   |
|   |   |
400 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
. | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | L | K | L | S | K | V | G | Q | . |
. |
. |
. |
. |
. |
A | L | L | Q | G | N | T | E | R | T | V | W | Q | Y | H | F | R | T | W | P | D | H | G | V | P | S | D | P | G | G | V | L | D | F | L | E | E | V | H | H | K | Q | E | S | I |
| Query Conservation |   |
  |
|   |
|   |   |   |   |   | . | . | . | . | . | . |   |   |   |   |   |   |   |   |
|   |
|   |
|   |   |
|   |   |
|
|
|   |
|
|
|   |   |   |   |   |   |
|   |
|
|   |   |
|   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
| Template Conservation |   |
  |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |
|   |   |   |   |   |
|
|
|   |   |
|
|   |   |   |   |   |   |
|   |   |   |   |   |
|   |   |   | . | . |   |   |
| Template Sequence |   |
R | F | S | I | R | N | T | K | V | K | K | G | Q | K | G | N | P | K | G | R | Q | N | E | R | V | V | I | Q | Y | H | Y | T | Q | W | P | D | M | G | V | P | E | Y | A | L | P | V | L | T | F | V | R | R | S | S | A | A | . |
. |
R | M |
| Template Known Secondary structure |   |
 |  |  |  |  |  | T | T | S |
|
|
|
| T | T |
| T | T |
|
| T | T |  |  |  |  |  |  |  |  |  |
|
|
|
| S | S | S | S |
| S |
| S |  |  |  |  |  |  |  |  |  |  |  |  | T | . | . |
|
|
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
| . | . |
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
993 | . | . | . | . | . | . | 1000 | . | . | . | . | . | . | . | . | . | 1010 | . | . | . | . | . | . | . | . | . | 1020 | . | . | . | . | . | . | . | . | . | 1030 | . | . | . | . | . | . | . | . | . | 1040 | . | . | . | . | . | . | . | . | |
|
. | 1050 |
|   |
|   |   |
454 | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
V | D | A | G | P | V | V | V | H | C | S | A | G | I | G | R | T | G | T | F | I | V | I | D | I | L | I | D | I | I | R | E | K | G | V | D | C | D | I | D | V | P | K | T | I | Q | M | V | R | S | Q | R | S | G | M | V | Q | T | E | A |
| Query Conservation |   |
  |   |   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |   |
|   |   |   |   |   |   |   |   |
|
|
|   |   |   |
|   |   |
|
|   |
|
|   |   |
|
|
|
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
|   |   |
|   |   |
|   |   |   |   | . | . | . |   |
|
|
|   |   |   |
|   |   |
|
|   |
|
|   |   |   |
|
|
|   |   |
| Template Sequence |   |
P | E | T | G | P | V | L | V | H | C | S | A | G | V | G | R | T | G | T | Y | I | V | I | D | S | M | L | Q | Q | I | K | D | K | S | . |
. |
. |
T | V | N | V | L | G | F | L | K | H | I | R | T | Q | R | N | Y | L | V | Q | T | E | E |
| Template Known Secondary structure |   |
S | S |
|
|
|  |  |  |  |
| S | S | S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | . | . | . |  |  |
|  |  |  |  |  |  |  |  | T | T | T | S | T | T | S | S |
|
|  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1051 | . | . | . | . | . | . | . | . | 1060 | . | . | . | . | . | . | . | . | . | 1070 | . | . | . | . | . | . | . | . | . | 1080 | . | . | . | . | |
|
|
. | . | . | . | . | 1090 | . | . | . | . | . | . | . | . | . | 1100 | . | . | . | . | . | . | . |
|   |
|   |   |
514 | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Q | Y | R | F | I | Y | M | A | V | Q | H | Y | I | E | T | L | Q | R | R | I | E | E | E | Q |
| Query Conservation |   |
|
|   |
|
|
|   |
|
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|   |
|   |
|   |   |
|   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |
| Template Sequence |   |
Q | Y | I | F | I | H | D | A | L | L | E | A | I | L | G | K | E | T | E | V | S | S | N | Q |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  | S |
|
|
|
|  |  | G | G | G |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1108 | . | 1110 | . | . | . | . | . | . | . | . | . | 1120 | . | . | . | . | . | . | . | . | . | 1130 | . |
|   |