|   |   |
216 | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
L | N | T | T | R | I | N | A | A | E | I | E | S | R | V | R | E | L | S | K | L | A | E | T | T | D | K | V | K | Q | G | F | W | E | E | F | E | T | L | Q | Q | Q | E | C | K | L | L | Y | S | R | K | E | G | Q | R | Q | E | N | K | N |
| Query Conservation |   |
  |   |   |
|   |
|   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |
|
|   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|   |
|   |   |   |   |   |   |
|   |   |   |   | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
| Template Sequence |   |
V | G | V | A | R | F | S | Q | W | E | V | E | R | W | V | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
D | A | S | T | H | E | L | T | Q | A | V | K | K | I | H | V | I | A | K | E | L | K | N | V | T | A | E | L | E | K | I | P | Q | T | M |
| Template Known Secondary structure |   |
S | S | S | S |
| G | G | G |
|
|  |  |  |  |  | . | . | . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|
|
|
|
|
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
239 | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | |
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . |
|   |
|   |   |
276 | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | |
. | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | |
| Predicted Secondary structure |   |
 |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
| . |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
| . |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
| Query Sequence |   |
K | N | R | Y | K | N | I | L | P | F | D | H | T | R | V | V | L | H | D | G | D | P | . |
N | E | P | V | S | D | Y | I | N | A | N | I | I | M | P | E | F | E | T | K | C | N | N | S | K | P | K | K | S | Y | I | A | T | Q | G | C | . |
| Query Conservation |   |
|
|
|
|   |
|
|
|
|
|
|   |
|
|
|   |
|   |   |   |   |   | . |   |   |   |   |
|
|
|
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|   |
| . |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
| Template Conservation |   |
|
|
|   |   |   |
|   |
|
|
|   |   |
|
|   |
|   |   |   |   |   |
|   |   |   |   |   |   |
|
|
|
|
|   |
|   | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |
|
|
|
|   |
|
|
| Template Sequence |   |
S | G | P | T | L | G | L | A | R | F | A | V | S | S | I | P | I | N | Q | Q | T | Q | V | K | L | S | D | G | M | P | V | P | V | N | T | L | T | . |
. |
. |
. |
. |
. |
. |
. |
. |
F | D | G | K | P | V | A | L | A | G | S | Y | P | K |
| Template Known Secondary structure |   |
|
|
|
|
| S |
|
| S | S |
| T | T | T | S |
|
|
| S | T | T |  |  |  |
| T | T |
|
|  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . |  | T | T |  |  |  |  |  |  |  |
| S |
|
|
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  | . | . | . | . | . | . | . | . | . |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
301 | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
. | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . |
|   |
|   |   |
|
334 | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . |
| Predicted Secondary structure |   |
. |
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
. |
L | Q | N | T | V | N | D | F | W | R | M | V | F | Q | E | N | S | R | V | I | V | M | T | T | K | E | V | E | R | G | K | S | K | C | V | K | Y | W | P | D | E | Y | A | L | K | E | Y | G | V | M | R | V | R | N | V | K | E | S | A |
| Query Conservation |   |
. |
|   |   |
|
|   |
|
|
|   |
|
|
|
|   |   |
|   |   |
|
|
|
|
|   |   |   |
|   |   |   |   |
|
|   |   |
|
|
|   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |
| Alig confidence |   |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|
|   |
|
|   |
|
|
|
|
|
|   |
|   |   |   |   |
|
|
|
|
|
|   |   |   |
|   |   |   |   |
|
|   |   |
|
|
| . | . | . |   |
|   |   |
|
|   |
|   |
|   |   |   |   |   |   |   |
| Template Sequence |   |
N | T | P | D | A | L | E | A | H | M | K | M | L | L | E | K | E | C | S | C | L | V | V | L | T | S | E | D | Q | M | Q | A | K | Q | L | P | P | Y | F | R | . |
. |
. |
G | S | Y | T | F | G | E | V | H | T | N | S | Q | K | V | S | S |
| Template Known Secondary structure |   |
S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
| S |
|  |  |  |
|
|
|  |  |  |  | T | T | T | T |
|
|
| T | T | T | . | . | . | S |  |  |  |  | T | T |  |  |  |  |  |  |  |
| G | G |
| Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|
| . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
352 | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | |
|
|
. | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . |
|   |
|   |   |
393 | . | . | |
. | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . |
| Predicted Secondary structure |   |
|
|
| . |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
A | H | D | . |
Y | T | L | R | E | L | K | L | S | K | V | G | Q | A | L | L | Q | G | N | T | E | R | T | V | W | Q | Y | H | F | R | T | W | P | D | H | G | V | P | S | D | P | G | G | V | L | D | F | L | E | E | V | H | H | K | Q | E |
| Query Conservation |   |
  |   |   | . |   |   |   |
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |
|   |   |
|   |   |
|
|
|   |
|
|
|   |   |   |   |   |   |
|   |
|
|   |   |
|   |   |   |   |   |
| Alig confidence |   |
|
|
| . |
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |
|   |   |   |
|   |   | . | . | . | . | . |   |   |   |   |   |   |
|   |
|   |
|   |
|   |   |   |
|
|
|   |
|
|
|   |   |   |   |   |
|
|   |
|
|   |   |
|   |   |   |   |   |
| Template Sequence |   |
A | S | Q | G | E | A | I | D | Q | Y | N | M | Q | L | . |
. |
. |
. |
. |
S | C | G | E | K | R | Y | T | I | P | V | L | H | V | K | N | W | P | D | H | Q | P | L | P | S | T | D | Q | L | E | Y | L | A | D | R | V | K | N | S | N | Q |
| Template Known Secondary structure |   |
G | S |
| S | T | T |  |  |  |  |  |  |  |  | . | . | . | . | . |  |  | T | T |  |  |  |  |  |  |  |  |  |  |
| S |
|
| T | T | S |
|
| S | S |  |  |  |  |  |  |  |  |  |  |  |  | T | S |
|
|
| Template Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |  |  |  |  | . | . | . | . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
409 | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | |
|
|
|
|
. | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . |
|   |
|   |   |
452 | . | . | . | . | |
|
|
|
|
|
. | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . |
| Predicted Secondary structure |   |
 |
|
|
|
| . | . | . | . | . | . |
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
S | I | V | D | A | . |
. |
. |
. |
. |
. |
G | P | V | V | V | H | C | S | A | G | I | G | R | T | G | T | F | I | V | I | D | I | L | I | D | I | I | R | E | K | G | V | D | C | D | I | D | V | P | K | T | I | Q | M | V | R | S | Q | R |
| Query Conservation |   |
  |   |   |   |   | . | . | . | . | . | . |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |   |
|   |   |   |   |   |   |   |   |
|
|
|   |   |   |
|   |   |
|
|   |
|
|
| Alig confidence |   |
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |   |
|   |   | . | . | . | . | . | . | . |   |   |   |   |   |
|   |   |
|
|   |   |
|
|   |   |
|
| Template Sequence |   |
N | G | A | P | G | R | S | S | S | D | K | H | L | P | M | I | H | C | L | G | G | V | G | R | T | G | T | M | A | A | A | L | V | L | K | D | . |
. |
. |
. |
. |
. |
. |
N | P | H | S | N | L | E | Q | V | R | A | D | F | R | D | S | R |
| Template Known Secondary structure |   |
|
|
| T | T |
| S |
| T | T | S | S |
|
|  |  |  | S | S | S | S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . |
| T | T |
|
|  |  |  |  |  |  |  |  |  |  |  | T |
| Template Predicted Secondary structure |   |
 |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
464 | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . |
|   |
|   |   |
506 | . | |
. | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
| . |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
S | G | . |
M | V | Q | T | E | A | Q | Y | R | F | I | Y | M | A | V | Q | H | Y | I |
| Query Conservation |   |
  |   | . |
|
|
|
|   |   |
|
|   |
|
|
|   |
|
|   |   |
|
|
| Alig confidence |   |
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |
|
|
|
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |
| Template Sequence |   |
N | N | R | M | L | E | D | A | S | Q | F | V | Q | L | K | A | M | Q | A | Q | L | L |
| Template Known Secondary structure |   |
| T | T | T | T |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
517 | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . |
|   |