Job Description Q64143 Confidence 100.00% Date Wed Jul 10 14:20:57 BST 2013 Rank 6 Aligned Residues 212 % Identity 33% Template c1a81E_ PDB info PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam Resolution 3.00 Å Model Dimensions (Å) X:48.610 Y:60.533 Z:35.952

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		59	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.			80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.
Predicted Secondary structure																							.	.
Query SS confidence																							.	.
Query Sequence		S	L	Q	D	A	E	W	Y	W	G	D	I	S	R	E	E	V	N	D	K	L	.	.	R	D	M	P	D	G	T	F	L	V	R	D	A	S	T	K	M	Q	G	D	Y	T	L	T	L	R	K	G	G	N	N	K	L	I	K	I	Y
Query Conservation																							.	.
Alig confidence																							.	.													.
Template Conservation																																					.
Template Sequence		S	A	N	H	L	P	F	F	F	G	N	I	T	R	E	E	A	E	D	Y	L	V	Q	G	G	M	S	D	G	L	Y	L	L	R	Q	.	S	R	N	Y	L	G	G	F	A	L	S	V	A	H	G	R	K	A	H	H	Y	T	I	E
Template Known Secondary structure			G	G	G		T	T			S	S												T	T	T			T	T							.		S	S	S	T	T									S	S	S
Template Predicted Secondary structure																																					.
Template SS confidence
		9	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.		.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.
			117	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.
Predicted Secondary structure		.
Query SS confidence		.
Query Sequence		.	H	R	D	G	K	Y	G	F	S	E	P	L	T	F	T	S	V	V	E	L	I	N	H	Y	H	H	E	S	L	A	Q	Y	N	P	K	L	D	V	K	L	T	Y	P	V	S	R	F	Q	Q	D	Q	L	V	K	E	D	N	I	D
Query Conservation		.
Alig confidence		.																																																					.	.	.	.	.	.	.
Template Conservation																																																							.	.	.	.	.	.	.
Template Sequence		R	E	L	N	G	T	Y	A	I	A	G	G	R	T	H	A	S	P	A	D	L	C	H	Y	H	S	Q	E	S	D	G	L	V	C	L	L	K	K	P	F	N	R	P	Q	G	V	Q	P	K	T	P	Q	L	.	.	.	.	.	.	.
Template Known Secondary structure				T	T	T					T	T	S			B	S	S									T	T			T	T	S	S	S				S	B					T	T									.	.	.	.	.	.	.
Template Predicted Secondary structure																																																							.	.	.	.	.	.	.
Template SS confidence
		68	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
		176	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	V	G	K	N	L	Q	E	F	H	S	Q	Y	Q	E	K	S	K	E	Y	D	R	L	Y	E	E	Y	T	R	T	S	Q	E	I	Q	M	K	R	T	A	I	E	A	F	N	E	T	I	K	I	F	E	E	Q	C	H	T	Q	E	Q
Query Conservation
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		236	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	S	K	D	Y	I	E	R	F	R	R	E	G	N	E	K	E	I	E	R	I	M	M	N	Y	D	K	L	K	S	R	L	G	E	I	H	D	S	K	L	R	L	E	Q	D	L	K	K	Q	A	L	D	N	R	E	I	D	K	K	M
Query Conservation
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		296	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	S	I	K	P	D	L	I	Q	L	R	K	I	R	D	Q	H	L	V	W	L	N	H	R	G	V	R	Q	R	R	L	N	A	W	L	G	I	K	N	E	D	S	D	E	S	Y	F	I	N	E	E	D	E	N	L	P	H	Y	D	E
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	E	K	L	I	A	T	T	A	H	E	K
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.							T	S	G	G	G
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
																																																			155	.	.	.	.	160	.	.	.	.	.
		356	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.			.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.
Predicted Secondary structure																			.	.
Query SS confidence																			.	.
Query Sequence		K	T	W	F	V	E	D	I	N	R	V	Q	A	E	D	L	L	.	.	Y	G	K	P	D	G	A	F	L	I	R	E	S	S	K	K	G	C	Y	A	C	S	V	V	A	D	G	E	V	K	H	C	V	I	Y	S	T	A	R	G	Y
Query Conservation																			.	.
Alig confidence																			.	.
Template Conservation
Template Sequence		M	P	W	F	H	G	K	I	S	R	E	E	S	E	Q	I	V	L	I	G	S	K	T	N	G	K	F	L	I	R	A	R	D	N	N	G	S	Y	A	L	C	L	L	H	E	G	K	V	L	H	Y	R	I	D	K	D	K	T	G	K
Template Known Secondary structure			T	T																S	S				T	T								S	S	S	S									T	T											T	T	S
Template Predicted Secondary structure
Template SS confidence
		166	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.
		414	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	F	A	E	P	Y	N	L	Y	S	S	L	K	E	L	V	L	H	Y	Q	Q	T	S	L	V	Q	H	N	D	S	L	N	V	R	L	A	Y	P	V
Query Conservation
Alig confidence																									.	.	.	.	.
Template Conservation																									.	.	.	.	.
Template Sequence		L	S	I	P	E	G	K	K	F	D	T	L	W	Q	L	V	E	H	Y	S	Y	K	A	.	.	.	.	.	D	G	L	L	R	V	L	T	V	P	C
Template Known Secondary structure					T	T	S			B	S										T	T			.	.	.	.	.	T	T	S	S	S				S	B
Template Predicted Secondary structure																									.	.	.	.	.
Template SS confidence
		226	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.						.	250	.	.	.	.	.	.	.	.	.

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D