Job Description P24604 Confidence 100.00% Date Tue Jul 30 13:00:36 BST 2013 Rank 277 Aligned Residues 256 % Identity 14% Template c2pvmA_ PDB info PDB header:transferase Chain: A: PDB Molecule:casein kinase ii subunit alpha; PDBTitle: structure-based design of pyrazolo[1,5-a][1,3,5]triazine2 derivatives as potent inhibitors of protein kinase ck2 Resolution 2.00 Å

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		364	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.		390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.
Predicted Secondary structure																												.
Query SS confidence																												.
Query Sequence		I	N	P	S	E	L	T	F	M	R	E	L	G	S	G	L	F	G	V	V	R	L	G	K	W	R	.	A	Q	Y	K	V	A	I	K	A	I	R	E	G	A	M	C	E	E	D	F	I	E	E	A	K	V	M	M	K	L	T	H	P
Query Conservation																												.
Alig confidence																												.														.	.
Template Conservation																																										.	.
Template Sequence		G	E	Q	D	D	Y	E	V	V	R	K	V	G	R	G	K	Y	S	E	V	F	E	G	I	N	V	N	N	N	E	K	C	I	I	K	I	L	K	P	V	.	.	K	K	K	K	I	K	R	E	I	K	I	L	Q	N	L	G	G	P
Template Known Secondary structure				G	G	G											S	S									T	T	T											S		.	.																		T
Template Predicted Secondary structure																																										.	.
Template SS confidence
		34	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.			.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
		423	.	.	.	.	.	.	430	.	.	.	.	.	.			.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Predicted Secondary structure																.	.
Query SS confidence																.	.
Query Sequence		K	L	V	Q	L	Y	G	V	C	T	Q	Q	K	P	.	.	I	Y	I	V	T	E	F	M	E	R	G	C	L	L	N	F	L	R	Q	R	Q	G	H	F	S	R	D	M	L	L	S	M	C	Q	D	V	C	E	G	M	E	Y	L	E
Query Conservation																.	.
Alig confidence																.	.																				.	.	.	.
Template Conservation																																					.	.	.	.
Template Sequence		N	I	V	K	L	L	D	I	V	R	D	Q	H	S	K	T	P	S	L	I	F	E	Y	V	N	N	T	D	F	K	V	L	Y	P	T	.	.	.	.	L	T	D	Y	D	I	R	Y	Y	I	Y	E	L	L	K	A	L	D	Y	C	H
Template Known Secondary structure		T	B										T	T	T																			G	G	G	.	.	.	.
Template Predicted Secondary structure																																					.	.	.	.
Template SS confidence
		93	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.					.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.
		481	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.		500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.
Predicted Secondary structure																					.																																								.
Query SS confidence																					.																																								.
Query Sequence		R	N	S	F	I	H	R	D	L	A	A	R	N	C	L	V	N	E	A	.	G	V	V	K	V	S	D	F	G	M	A	R	Y	V	L	D	D	Q	Y	T	S	S	S	G	A	K	F	P	V	K	W	C	P	P	E	V	F	N	Y	.
Query Conservation																					.																																								.
Alig confidence																					.																										.	.													.
Template Conservation																																															.	.
Template Sequence		S	Q	G	I	M	H	R	D	V	K	P	H	N	V	M	I	D	H	E	L	R	K	L	R	L	I	D	W	G	L	A	E	F	Y	H	P	G	K	E	Y	N	V	R	V	A	.	.	S	R	Y	F	K	G	P	E	L	L	V	D	L
Template Known Secondary structure			T	T							S	G	G	G					T	T	T	T								T	T						T	T					S			S	.	.		G	G	G							T	T
Template Predicted Secondary structure																																															.	.
Template SS confidence
		149	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.			.	.	.	.	.	.	200	.	.	.	.	.	.
		539	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.
Predicted Secondary structure																																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		S	R	F	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	I	F	T	E	G	R	M	P	F	E	K	N	T	N	Y	E	V	V	T	M	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation																																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		Q	D	Y	D	Y	S	L	D	M	W	S	L	G	C	M	F	A	G	M	I	F	R	K	E	P	F	F	Y	G	H	D	N	H	D	Q	L	V	K	I	A	K	V	L	G	T	D	G	L	N	A	Y	L	N	K	Y	R	I	E	L	D
Template Known Secondary structure			S			T																	T		S	S	S	S			S	S																								T	T
Template Predicted Secondary structure
Template SS confidence
		207	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.
																577	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.			.	.	.	620
Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Query SS confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Query Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	V	T	R	G	H	R	L	H	R	P	K	L	A	T	K	Y	L	Y	E	V	M	L	R	C	W	Q	E	R	P	E	G	R	P	S	L	E	D	L	L	R	.	.	T	I	D	E
Query Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.																																									.	.
Template Conservation
Template Sequence		P	Q	L	E	A	L	V	G	R	H	S	R	K	P	W	L	K	F	M	N	A	D	N	Q	H	L	V	S	P	E	A	I	D	F	L	D	K	L	L	R	Y	D	H	Q	E	R	L	T	A	L	E	A	M	T	H	P	Y	F	Q	Q
Template Known Secondary structure																G	G	G	G			T	T	T	G	G	G											T	T			S	S	T	T	T	S									S	G	G	G
Template Predicted Secondary structure
Template SS confidence
		267	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.
		621	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	V	E	C	E	E	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		V	R	A	A	E	N	S
Template Known Secondary structure							T
Template Predicted Secondary structure
Template SS confidence
		327	.	.	330	.	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D