Job Description P24604 Confidence 100.00% Date Tue Jul 30 13:00:36 BST 2013 Rank 2 Aligned Residues 441 % Identity 40% Template c1oplA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase Resolution 3.42 Å Model Dimensions (Å) X:66.712 Y:73.573 Z:55.294

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		179	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	E	E	I	V	V	A	M	Y	D	F	Q	A	T	E	A	H	D	L	R	L	E	R	G	Q	E	Y	I	I	L	E	K	N	D	L	H	W	W	R	A	R	D	K	Y	G	S	E	G	Y	I	P	S	N	Y	V	T	G	K	K	S
Query Conservation
Alig confidence																																																										.	.
Template Conservation																																																										.	.
Template Sequence		D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	K	N	G	Q	G	W	V	P	S	N	Y	I	T	.	.	P	V
Template Known Secondary structure			T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							S	S							G	G	G			.	.		S
Template Predicted Secondary structure																																																										.	.
Template SS confidence
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.			.	.
		239	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.		.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.
Predicted Secondary structure																																						.
Query SS confidence																																						.
Query Sequence		N	N	L	D	Q	Y	E	W	Y	C	R	N	T	N	R	S	K	A	E	Q	L	L	R	T	E	D	K	E	G	G	F	M	V	R	D	S	.	S	Q	P	G	L	Y	T	V	S	L	Y	T	K	F	G	G	E	G	S	S	G	F	R
Query Conservation																																						.
Alig confidence																										.												.													.	.	.	.	.	.
Template Conservation																										.																									.	.	.	.	.	.
Template Sequence		N	S	L	E	K	H	S	W	Y	H	G	P	V	S	R	N	A	A	E	Y	L	L	S	S	.	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	.	.	.	.	.	.	E	G	R	V	Y
Template Known Secondary structure		S	S	G	G	G	S	T	T														G	G	G	.			T	T								S	S	S	T	T									.	.	.	.	.	.	T	T
Template Predicted Secondary structure																										.																									.	.	.	.	.	.
Template SS confidence
		139	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.		.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.							.	.	.	190	.
		298	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	Y	H	I	K	E	T	A	T	S	P	K	K	Y	Y	L	A	E	K	H	A	F	G	S	I	P	E	I	I	E	Y	H	K	H	N	A	A	G	L	V	T	R	L	R	Y	P	V	S	T	K	G	K	N	A	P	T	T	A	G	F
Query Conservation
Alig confidence													.	.
Template Conservation													.	.
Template Sequence		H	Y	R	I	N	T	A	S	D	G	K	.	.	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P
Template Known Secondary structure									T	T	S		.	.			S	S	T	T	S		B	S	S									T	T			T	T	S	S	S										S					S	S	S		S
Template Predicted Secondary structure													.	.
Template SS confidence
		192	.	.	.	.	.	.	.	200	.	.			.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.
		358	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390		.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.
Predicted Secondary structure																																			.
Query SS confidence																																			.
Query Sequence		S	Y	D	K	W	E	I	N	P	S	E	L	T	F	M	R	E	L	G	S	G	L	F	G	V	V	R	L	G	K	W	R	A	.	Q	Y	K	V	A	I	K	A	I	R	E	G	A	M	C	E	E	D	F	I	E	E	A	K	V	M
Query Conservation																																			.
Alig confidence																																			.
Template Conservation
Template Sequence		N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L	K	E	A	A	V	M
Template Known Secondary structure		S	S	S			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.
		417	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.		460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.
Predicted Secondary structure																																													.
Query SS confidence																																													.
Query Sequence		M	K	L	T	H	P	K	L	V	Q	L	Y	G	V	C	T	Q	Q	K	P	I	Y	I	V	T	E	F	M	E	R	G	C	L	L	N	F	L	R	Q	R	Q	G	H	.	F	S	R	D	M	L	L	S	M	C	Q	D	V	C	E	G
Query Conservation																																													.
Alig confidence																																													.
Template Conservation
Template Sequence		K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A
Template Known Secondary structure							T	T	B									S	S	S	S									T	T		B								S		T	T	T	S
Template Predicted Secondary structure
Template SS confidence
		310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.
		476	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		M	E	Y	L	E	R	N	S	F	I	H	R	D	L	A	A	R	N	C	L	V	N	E	A	G	V	V	K	V	S	D	F	G	M	A	R	Y	V	L	D	D	Q	Y	T	S	S	S	G	A	K	F	P	V	K	W	C	P	P	E	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S
Template Known Secondary structure								T	T				S			S	G	G	G					G	G	G							T	T						T	T							T	T					G	G	G
Template Predicted Secondary structure
Template SS confidence
		370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.
		536	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	N	Y	S	R	F	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	I	F	T	E	G	R	M	P	F	E	K	N	T	N	Y	E	V	V	T	M	V	T	R	G	H	R	L	H	R	P	K	L	A	T	K	Y	L	Y	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E
Template Known Secondary structure																									T	T	S			S	S	T	T			T	T	T							T	T							T	T
Template Predicted Secondary structure
Template SS confidence
		430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.
		596	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.								.	.	.	.	.	.	630
Predicted Secondary structure																														.	.	.	.	.	.	.
Query SS confidence																														.	.	.	.	.	.	.
Query Sequence		V	M	L	R	C	W	Q	E	R	P	E	G	R	P	S	L	E	D	L	L	R	T	I	D	E	L	V	E	.	.	.	.	.	.	.	C	E	E	T	F	G	R
Query Conservation																														.	.	.	.	.	.	.
Alig confidence																														.	.	.	.	.	.	.
Template Conservation
Template Sequence		L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S	I	S	D	E	V	E	K	E	L	G	K
Template Known Secondary structure							T		S	S	G	G	G	S												T	S		S	S	S
Template Predicted Secondary structure
Template SS confidence
		490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.