Email l.a.kelley@imperial.ac.uk Description Q8R4L0 Date Tue Jul 30 13:18:27 BST 2013 Unique Job ID 0a7e693b9aaa9644

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1y57A_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 2 c2c0iA_ 100.0 38 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 3 c2h8hA_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 4 c2fo0A_ 100.0 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 5 c1oplA_ 100.0 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 6 c1x27F_ 100.0 45 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 7 c3nhnA_ 100.0 43 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 8 c1k9aB_ 100.0 30 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 9 c2ablA_ 100.0 33 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 10 c1g83A_ 100.0 44 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 11 d1a81a1 100.0 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 12 d2oq1a1 100.0 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 13 d1lkka_ 100.0 50 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 14 c2oq1A_ 100.0 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 15 d1qcfa2 100.0 50 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 16 d1f2fa_ 100.0 45 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 17 d1bkla_ 100.0 43 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 18 c2dlyA_ 100.0 35 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 19 d2oq1a2 100.0 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 20 d1g83a2 100.0 47 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 21 d1o48a_ not modelled 100.0 42 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 22 d1blja_ not modelled 100.0 46 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 23 d1a81e1 not modelled 100.0 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 24 c2ozoA_ not modelled 100.0 33 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 25 c4fl2A_ not modelled 100.0 33 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 26 d1rjaa_ not modelled 100.0 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 27 d1a81a2 not modelled 100.0 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 28 d1a81e2 not modelled 100.0 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 29 c2eo3A_ not modelled 100.0 33 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 30 d1csya_ not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 c2b3oA_ not modelled 99.9 29 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 32 d1nrva_ not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 33 d1cwea_ not modelled 99.9 51 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 c2ysxA_ not modelled 99.9 30 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 35 c2knoA_ not modelled 99.9 30 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 36 c2augB_ not modelled 99.9 25 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 37 c2ge9A_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 38 c2el8A_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 39 c1a81E_ not modelled 99.9 36 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 40 c2eo6A_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 41 d2qmsa1 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 c3hizB_ not modelled 99.9 28 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 43 c2lqnA_ not modelled 99.9 30 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 44 c1ka6A_ not modelled 99.9 28 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 45 d1opka2 not modelled 99.9 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 46 c2dm0A_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 47 c2y3aB_ not modelled 99.9 35 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 48 c2gsbA_ not modelled 99.9 23 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 49 d1d4ta_ not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 50 d1k9aa2 not modelled 99.9 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 51 d1i3za_ not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 c2shpA_ not modelled 99.9 29 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 53 d1luia_ not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 54 d1jwoa_ not modelled 99.9 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d2shpa2 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 d2shpa3 not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 d1fhsa_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 c1x6cA_ not modelled 99.9 35 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 59 d2izva2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 c2eobA_ not modelled 99.9 29 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 61 c2ekxA_ not modelled 99.9 25 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 62 c2dlzA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 63 c2crhA_ not modelled 99.9 19 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 64 c2hdxB_ not modelled 99.9 28 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 65 c3ps5A_ not modelled 99.9 29 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 66 d1pica_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 67 d2eyva1 not modelled 99.9 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 d3c7ia1 not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 69 c3gqiB_ not modelled 99.9 27 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 70 c2c9wA_ not modelled 99.9 29 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 71 c2lctA_ not modelled 99.9 23 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 72 d1ayaa_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 73 c2vifA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 74 c3mazA_ not modelled 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 75 d2cs0a1 not modelled 99.9 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 d1qada_ not modelled 99.9 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d2fcia1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 d1r1qa_ not modelled 99.9 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 d1jyra_ not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 c2hmhA_ not modelled 99.9 27 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 81 c2izvA_ not modelled 99.9 26 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 82 c2ci8A_ not modelled 99.9 29 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 83 d2c9wa2 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1fu6a_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 c1rqqC_ not modelled 99.9 33 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 86 d1mila_ not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 c2dcrA_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 88 d1rpya_ not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c2kk6A_ not modelled 99.8 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 90 d1xa6a2 not modelled 99.8 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 91 c3qwyA_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 92 c2dvjA_ not modelled 99.8 30 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 93 c3gxxB_ not modelled 99.8 20 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 94 c3qwxX_ not modelled 99.8 24 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 95 c2eyzA_ not modelled 99.8 31 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 96 c2cr4A_ not modelled 99.8 23 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 97 c2eyyA_ not modelled 99.8 30 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 98 c2dx0B_ not modelled 99.8 41 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 99 c3or8A_ not modelled 99.7 24 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 100 c1griA_ not modelled 99.7 27 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 101 c2xp1A_ not modelled 99.6 20 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 102 c2yt6A_ 99.6 35 PDB header:cell cycle Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full- PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1 103 d1uura3 not modelled 99.6 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 104 c1xa6A_ not modelled 99.6 41 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 105 d1bf5a3 not modelled 99.5 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 106 c3cblA_ not modelled 99.4 35 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide 107 c2cudA_ not modelled 99.4 28 PDB header:signaling protein Chain: A: PDB Molecule:src-like-adapter; PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap) 108 c2jxbA_ not modelled 99.4 20 PDB header:signaling protein complex Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain, PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex 109 d1bg1a3 not modelled 99.4 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 110 c2oi3A_ not modelled 99.3 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1) 111 c1mv3A_ not modelled 99.3 15 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc 112 c2rqrA_ not modelled 99.3 19 PDB header:protein binding Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex 113 c1x6gA_ not modelled 99.2 16 PDB header:signaling protein Chain: A: PDB Molecule:megakaryocyte-associated tyrosine-protein kinase; PDBTitle: solution structures of the sh3 domain of human2 megakaryocyte-associated tyrosine-protein kinase. 114 c2yupA_ not modelled 99.2 23 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the second sh3 domain of human vinexin 115 d1lcka1 not modelled 99.2 31 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 116 c1x6bA_ not modelled 99.2 9 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine exchange factor (gef) 16; PDBTitle: solution structures of the sh3 domain of human rho guanine2 exchange factor (gef) 16 117 d1awja_ not modelled 99.2 22 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 118 d2iima1 not modelled 99.2 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 119 d1udla_ not modelled 99.1 20 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 120 c2fpeB_ not modelled 99.1 20 PDB header:signaling protein Chain: B: PDB Molecule:c-jun-amino-terminal kinase interacting protein PDBTitle: conserved dimerization of the ib1 src-homology 3 domain