BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (259 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2...   384   e-105
UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 ...   304   2e-81
UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homini...   276   4e-73
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   236   6e-61
UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A...   202   1e-50
UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_...   192   1e-47
UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q...   186   6e-46
UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun se...   176   6e-43
UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tet...   161   2e-38
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   139   8e-32
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   138   2e-31
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   137   5e-31
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   135   1e-30
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   134   3e-30
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   133   5e-30
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   132   1e-29
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...   130   3e-29
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   124   3e-27
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   122   9e-27
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   119   9e-26
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   118   2e-25
UniRef50_B7Z4J2 cDNA FLJ50391, highly similar to SRC-like-adapte...   116   9e-25
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   114   5e-24
UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californic...   112   1e-23
UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   110   5e-23
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   107   5e-22
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   105   1e-21
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...    98   4e-19
UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...    96   1e-18
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    96   1e-18
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...    95   2e-18
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...    91   4e-17
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...    89   1e-16
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...    89   2e-16
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...    89   2e-16
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...    87   4e-16
UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun se...    84   3e-15
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...    83   7e-15
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...    82   1e-14
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...    82   2e-14
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...    81   4e-14
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...    80   5e-14
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...    80   6e-14
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...    80   7e-14
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...    80   8e-14
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...    79   1e-13
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...    79   1e-13
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...    79   2e-13
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...    77   5e-13
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...    77   6e-13
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...    76   8e-13
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS           76   9e-13
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...    76   9e-13
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO           76   9e-13
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...    76   1e-12
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...    75   2e-12
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...    75   2e-12
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...    75   2e-12
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    74   3e-12
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...    74   4e-12
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...    73   7e-12
UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichop...    73   9e-12
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...    72   1e-11
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...    72   2e-11
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...    72   2e-11
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...    72   2e-11
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE      72   2e-11
UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE       72   2e-11
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...    72   2e-11
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...    72   3e-11
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...    72   3e-11
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...    71   3e-11
UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative ...    71   4e-11
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...    71   4e-11
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...    70   5e-11
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...    70   5e-11
UniRef50_P78453 Tyrosine kinase (Fragment) n=11 Tax=Euteleostomi...    70   7e-11
UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE     69   1e-10
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...    69   2e-10
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...    68   2e-10
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...    68   3e-10
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...    67   5e-10
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...    67   6e-10
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...    67   7e-10
UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n...    67   8e-10
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...    66   9e-10
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    66   9e-10
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...    66   9e-10
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...    66   9e-10
UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo sal...    66   1e-09
UniRef50_UPI00015B5EF2 PREDICTED: similar to ENSANGP00000021630 ...    66   1e-09
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...    65   2e-09
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...    65   3e-09
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...    64   4e-09
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...    64   5e-09
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...    64   6e-09
UniRef50_UPI000186F028 conserved hypothetical protein n=1 Tax=Pe...    64   6e-09
UniRef50_UPI0000D555ED PREDICTED: similar to CG33993 CG33993-PA ...    63   8e-09
UniRef50_B1AH86 GRB2-related adaptor protein 2 (Fragment) n=3 Ta...    63   1e-08
UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Dan...    62   1e-08
UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostom...    62   2e-08
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI          61   4e-08
UniRef50_Q7Q480 AGAP008273-PA (Fragment) n=3 Tax=Culicidae RepID...    60   7e-08
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...    60   7e-08
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...    60   7e-08
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...    60   8e-08
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...    60   9e-08
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...    60   9e-08
UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    59   1e-07
UniRef50_Q4T2Z8 Chromosome 18 SCAF10147, whole genome shotgun se...    59   1e-07
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...    59   2e-07
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...    59   2e-07
UniRef50_A7URX1 AGAP006893-PA n=3 Tax=Culicidae RepID=A7URX1_ANOGA     59   2e-07
UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=...    58   3e-07
UniRef50_B7QKA0 Putative uncharacterized protein n=1 Tax=Ixodes ...    58   3e-07
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...    58   3e-07
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...    57   6e-07
UniRef50_C4Q5Y9 Tensin-related n=1 Tax=Schistosoma mansoni RepID...    57   6e-07
UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchi...    57   7e-07
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...    57   9e-07
UniRef50_Q56A36 Hematopoietic SH2 domain-containing protein homo...    57   9e-07
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    56   1e-06
UniRef50_Q6NR09 CG33993 n=13 Tax=Diptera RepID=Q6NR09_DROME            56   1e-06
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...    56   1e-06
UniRef50_UPI000180B667 PREDICTED: similar to GF12762 n=1 Tax=Cio...    56   1e-06
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...    56   1e-06
UniRef50_Q9VRS2 CG32406 n=13 Tax=Drosophila RepID=Q9VRS2_DROME         56   1e-06
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...    55   2e-06
UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicu...    55   2e-06
UniRef50_C3ZG97 Putative uncharacterized protein n=3 Tax=Chordat...    55   2e-06
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...    55   2e-06
UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE       55   3e-06
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...    54   4e-06
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...    54   4e-06
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...    54   5e-06
UniRef50_Q85476 (recovered insertion mutant of B77) src (Fragmen...    54   6e-06
UniRef50_Q5BXE5 SJCHGC04002 protein (Fragment) n=1 Tax=Schistoso...    54   7e-06
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    54   7e-06
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...    54   7e-06
UniRef50_Q4TFA7 Chromosome 21 SCAF4724, whole genome shotgun seq...    54   7e-06
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...    53   8e-06
UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluvia...    53   1e-05
UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi s...    53   1e-05
UniRef50_A9V5H9 Predicted protein n=1 Tax=Monosiga brevicollis R...    53   1e-05
UniRef50_Q380D8 AGAP001259-PA (Fragment) n=3 Tax=Culicidae RepID...    52   2e-05
UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepI...    52   2e-05
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE         52   2e-05
UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes...    52   2e-05
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...    52   2e-05
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...    52   3e-05
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...    51   3e-05
UniRef50_Q22070 Protein T01E8.3, partially confirmed by transcri...    51   3e-05
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...    51   3e-05
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME         51   4e-05
UniRef50_A7T8K3 Predicted protein n=1 Tax=Nematostella vectensis...    51   4e-05
UniRef50_UPI00016E9C47 UPI00016E9C47 related cluster n=1 Tax=Tak...    50   5e-05
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...    50   5e-05
UniRef50_A8WUN8 C. briggsae CBR-SHC-2 protein n=8 Tax=Caenorhabd...    50   6e-05
UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleos...    50   6e-05
UniRef50_A7RU23 Predicted protein n=1 Tax=Nematostella vectensis...    50   7e-05
UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Br...    50   8e-05
UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Tak...    50   8e-05
UniRef50_UPI000155BA92 PREDICTED: similar to Fyn-related kinase,...    50   9e-05
UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n...    50   1e-04
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...    50   1e-04
UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction...    50   1e-04
UniRef50_Q8MQW8 Protein sprint n=6 Tax=Drosophila RepID=SPRI_DROME     49   1e-04
UniRef50_A9V545 Predicted protein n=1 Tax=Monosiga brevicollis R...    49   1e-04
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...    49   1e-04
UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_S...    49   1e-04
UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS          49   1e-04
UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound p...    49   1e-04
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN          49   2e-04
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...    49   2e-04
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...    49   2e-04
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    48   3e-04
UniRef50_P50745 SH2B adapter protein 3 n=2 Tax=Rattus norvegicus...    48   3e-04
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...    48   3e-04
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...    48   3e-04
UniRef50_Q9VHC3 Blistery n=8 Tax=Sophophora RepID=Q9VHC3_DROME         48   4e-04
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    48   4e-04
UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2...    47   4e-04
UniRef50_UPI00019273B6 PREDICTED: similar to Phosphatidylinosito...    47   5e-04
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...    47   5e-04
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...    47   5e-04
UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n...    47   5e-04
UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    47   5e-04
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...    47   5e-04
UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi Rep...    47   5e-04
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...    47   6e-04
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...    47   6e-04
UniRef50_B3S2E5 Putative uncharacterized protein n=1 Tax=Trichop...    47   6e-04
UniRef50_B4JFU1 GH19392 (Fragment) n=6 Tax=cellular organisms Re...    47   6e-04
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...    47   6e-04
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    47   7e-04
UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorh...    47   7e-04
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...    47   7e-04
UniRef50_A9UQX3 Predicted protein n=1 Tax=Monosiga brevicollis R...    47   8e-04
UniRef50_A9V1L3 Predicted protein n=1 Tax=Monosiga brevicollis R...    47   8e-04
UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_...    47   8e-04
UniRef50_A9V5F5 Predicted protein n=1 Tax=Monosiga brevicollis R...    47   8e-04
UniRef50_P52735 Guanine nucleotide exchange factor VAV2 n=43 Tax...    47   8e-04
UniRef50_C3YUH5 Putative uncharacterized protein n=1 Tax=Branchi...    47   9e-04
UniRef50_C1BXS5 Tyrosine-protein kinase HCK n=1 Tax=Esox lucius ...    47   9e-04
UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=...    47   9e-04
UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=T...    47   0.001
UniRef50_UPI000179134F PREDICTED: similar to signal transduction...    46   0.001
UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=S...    46   0.001
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...    46   0.001
UniRef50_Q8IZW8 Tensin-4 n=12 Tax=Eutheria RepID=TENS4_HUMAN           46   0.001
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...    46   0.001
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...    46   0.001
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...    46   0.001
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...    46   0.001
UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa ...    46   0.001
UniRef50_Q4T639 Chromosome undetermined SCAF8942, whole genome s...    46   0.001
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...    46   0.002
UniRef50_A9V2D7 Predicted protein n=1 Tax=Monosiga brevicollis R...    45   0.002
UniRef50_B3SCQ7 Putative uncharacterized protein n=1 Tax=Trichop...    45   0.002
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...    45   0.002
UniRef50_A8PYV3 Variant SH3 domain containing protein n=1 Tax=Br...    45   0.002
UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tet...    45   0.002
UniRef50_B7Q548 Phosphoinositide-3-kinase, regulatory subunit, p...    45   0.002
UniRef50_A9V6N4 Predicted protein n=1 Tax=Monosiga brevicollis R...    45   0.003
UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS          45   0.003
UniRef50_UPI000069FBD6 Tensin-like C1 domain-containing phosphat...    45   0.003
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...    45   0.003
UniRef50_B4JBG9 GH11549 n=1 Tax=Drosophila grimshawi RepID=B4JBG...    45   0.003
UniRef50_A9V6N9 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.004
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...    44   0.004
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    44   0.004
UniRef50_A7UTR8 AGAP005583-PA n=2 Tax=Anopheles gambiae RepID=A7...    44   0.005
UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Tak...    44   0.005
UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (...    44   0.006
UniRef50_UPI000069FBD8 Tensin-like C1 domain-containing phosphat...    44   0.006
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...    44   0.006
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...    44   0.006
UniRef50_Q17M69 Rab gdp/gtp exchange factor n=3 Tax=Culicidae Re...    44   0.007
UniRef50_Q9HBL0 Tensin-1 n=79 Tax=Eumetazoa RepID=TENS1_HUMAN          44   0.007
UniRef50_B7QCJ2 Growth factor receptor-bound protein, putative n...    44   0.007
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...    44   0.008
UniRef50_UPI000194DBC6 PREDICTED: similar to tensin 4 n=1 Tax=Ta...    43   0.008
UniRef50_A4F2N7 Mt-tensin-b (Fragment) n=2 Tax=Molgula tectiform...    43   0.008
UniRef50_B7P3R5 Suppressor of cytokine signaling-2, putative (Fr...    43   0.008
UniRef50_UPI000069FBD7 Tensin-like C1 domain-containing phosphat...    43   0.008
UniRef50_C3YCZ8 Putative uncharacterized protein n=1 Tax=Branchi...    43   0.009
UniRef50_Q8INY1 Suppressor of cytokine signaling at 36E, isoform...    43   0.009
UniRef50_B0ETU6 Proline-serine-threonine phosphatase interacting...    43   0.010
UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY3...    43   0.010
UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichop...    43   0.010

>UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2_HUMAN
          Length = 261

 Score =  384 bits (987), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 205/262 (78%), Positives = 221/262 (84%), Gaps = 4/262 (1%)

Query: 1   MGSLSSRGKTSSPSPSSSGPD-QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGSL SR K+      SS    Q PV+M+ ER K TAVALGSFPAG  A LSLRLGEPLT
Sbjct: 1   MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+SEDGDWWTV SEVSGREY++PSV+VAKV+HGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61  IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RESQTRRG YSLSVRLSRPASWDRIRHYRI  LDNGWLYISPRLTFPSL ALV+HYSELA
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA 180

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           D ICC L+EPCVLQ+ GPLPGKD P PVTV  + LNWK+LD SLLF EA A+GE SLLSE
Sbjct: 181 DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEA-ATGEESLLSE 239

Query: 240 GLRESLSSYISLAEDP--LDDA 259
           GLRESLS YISL ++   LDDA
Sbjct: 240 GLRESLSFYISLNDEAVSLDDA 261


>UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 n=1 Tax=Monodelphis
           domestica RepID=UPI0000F2B3BE
          Length = 310

 Score =  304 bits (779), Expect = 2e-81,   Method: Compositional matrix adjust.
 Identities = 145/223 (65%), Positives = 179/223 (80%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
           K  AVAL SFPAGEQ  L LRLGEPL IIS++G+WW V SE + +EY +PS +VA+++ G
Sbjct: 74  KDMAVALDSFPAGEQGELVLRLGEPLIIISDNGEWWRVLSEATSKEYVVPSSHVARISQG 133

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WLYEGL+REKAE+LLLLP N GG+FLIRESQTRRG YSLSVRLSRP S D +RHYRI RL
Sbjct: 134 WLYEGLNREKAEDLLLLPSNHGGSFLIRESQTRRGAYSLSVRLSRPTSRDVVRHYRIHRL 193

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
           +NGW YISPRLTFPSL ALVEHY+E+AD +C  L EPC  +++G LPG++ PPPV+V   
Sbjct: 194 ENGWFYISPRLTFPSLQALVEHYTEMADDLCSLLVEPCAFRRVGLLPGRNIPPPVSVQRP 253

Query: 213 SLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDP 255
           +LNWK++D SLLF E  +SG+   +S GLRE++ +YIS+ EDP
Sbjct: 254 TLNWKEVDSSLLFSEVSSSGDTCPISVGLREAIGTYISMTEDP 296


>UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homininae RepID=Q9H6Q3-2
          Length = 210

 Score =  276 bits (706), Expect = 4e-73,   Method: Compositional matrix adjust.
 Identities = 145/178 (81%), Positives = 154/178 (86%), Gaps = 1/178 (0%)

Query: 1   MGSLSSRGKTSSPSPSSSGPD-QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGSL SR K+      SS    Q PV+M+ ER K TAVALGSFPAG  A LSLRLGEPLT
Sbjct: 1   MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+SEDGDWWTV SEVSGREY++PSV+VAKV+HGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61  IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           RESQTRRG YSLSVRLSRPASWDRIRHYRI  LDNGWLYISPRLTFPSL ALV+HYSE
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  236 bits (602), Expect = 6e-61,   Method: Compositional matrix adjust.
 Identities = 117/228 (51%), Positives = 155/228 (67%), Gaps = 2/228 (0%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA 87
           Q    K   VAL +FP   Q  LS+  GE L I+SEDGDW  V S  +G+E ++P+ YVA
Sbjct: 24  QAAADKCIFVALYNFPLSGQTDLSIHFGEQLNILSEDGDWLKVSSASTGQECYLPTNYVA 83

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
           KV + WLY+G++REKAEELL++  N  G+FLIRES+TR G Y+LS+R +   S D I+HY
Sbjct: 84  KVCNRWLYKGINREKAEELLMVNSNRSGSFLIRESETRSGSYTLSIRKTNHTSRDSIKHY 143

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP-P 206
           RI +LDNGW YI+PRLTF +L  +V++YSE+ADGICC L EPCV+Q++ P P    P  P
Sbjct: 144 RIHQLDNGWFYIAPRLTFATLQDMVDYYSEVADGICCTLTEPCVVQRV-PNPVIQRPSEP 202

Query: 207 VTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
           + V   +LNW KLD   LF +     E   LS GLRE++SSY+ + +D
Sbjct: 203 IVVRKPTLNWTKLDSMDLFNKDDKLNEDCPLSLGLREAVSSYMLMTQD 250


>UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A9JR87_DANRE
          Length = 264

 Score =  202 bits (513), Expect = 1e-50,   Method: Compositional matrix adjust.
 Identities = 100/234 (42%), Positives = 153/234 (65%), Gaps = 3/234 (1%)

Query: 24  PVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPS 83
           P++M+  R+ +  V+L  +P+      ++R+GE L I+S++G+W+ V S  +G E ++PS
Sbjct: 27  PLTMESIRYVL--VSLYDYPSRGPGDCAIRVGERLNILSDEGEWFKVSSSATGNESYIPS 84

Query: 84  VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
            Y AK+ + W + GLS+ K+EELL+LP N  G+FLIRES+T  G Y+LSVR S       
Sbjct: 85  NYTAKLYNRWQFVGLSKRKSEELLMLPHNQPGSFLIRESETFPGNYTLSVRKSGSQERAS 144

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           ++HYRI  +DNGW YISP LTF +L  ++ HYS ++DG+CC L EPC +     +P  + 
Sbjct: 145 VKHYRISCIDNGWFYISPGLTFRTLSDMIAHYS-VSDGLCCTLGEPCFIIGSNNVPVVNG 203

Query: 204 PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLD 257
            PPV V   ++NWK +D S++F +     E SL+SEGL+E+++SY+ + E   D
Sbjct: 204 APPVAVKRPTINWKDVDSSMIFSQTKEGAEDSLVSEGLKEAINSYLYMTEKCED 257


>UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_HUMAN
          Length = 276

 Score =  192 bits (487), Expect = 1e-47,   Method: Compositional matrix adjust.
 Identities = 100/221 (45%), Positives = 139/221 (62%), Gaps = 9/221 (4%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYE 96
             L  +P+ + +    R GE L +IS++G WW   S  +GRE ++P + VA+V HGWL+E
Sbjct: 28  AVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFE 87

Query: 97  GLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW 156
           GL R+KAEELL LP    G+F+IRES+T++G YSLSVR        +++HYRI RL N W
Sbjct: 88  GLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR------QVKHYRIFRLPNNW 141

Query: 157 LYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNW 216
            YISPRLTF  L  LV HYSE+ADG+CC L  PC+ Q       + +  PVT+   +++W
Sbjct: 142 YYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDW 201

Query: 217 KKLDR---SLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
           +++ R        E P   + SL S GLRES++SY+SL  +
Sbjct: 202 RRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLTSE 242


>UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q3ZB94_DANRE
          Length = 271

 Score =  186 bits (472), Expect = 6e-46,   Method: Compositional matrix adjust.
 Identities = 109/256 (42%), Positives = 154/256 (60%), Gaps = 21/256 (8%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG+++ +G T+   P S+  D    SM  +    T V L  +P  + +    ++G+ L  
Sbjct: 1   MGNVTRQGHTN---PESNSLD----SMFKDCD--TLVVLADYPCRDISEPVFKMGDRLKG 51

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           +SEDG WW V+S  +G E ++P  +V+KV HGWL+EG+SR+KAEELL LPGN  G+FLIR
Sbjct: 52  LSEDGCWWKVRSLQTGTENYIPCNHVSKVYHGWLFEGVSRQKAEELLSLPGNSAGSFLIR 111

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES   RG YSLSVR         ++HY+I RL N W YISPRLTF  L  +V HYS+ +D
Sbjct: 112 ESPRERGLYSLSVRHR------SVKHYKIFRLTNSWYYISPRLTFQCLEDMVNHYSDSSD 165

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF----LEAPASGEASL 236
           GICC L  PC L    P P      P  V   +L+W K+ +S L     L++  S + ++
Sbjct: 166 GICCVLSAPC-LALSNPTPSSIQGAPPVVMRRNLDWNKVKKSQLLNPSELDSVDSRD-NM 223

Query: 237 LSEGLRESLSSYISLA 252
           +S G+R S+++Y+SL 
Sbjct: 224 MSYGVRSSIAAYLSLT 239


>UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Tetraodontidae RepID=Q4SUZ3_TETNG
          Length = 232

 Score =  176 bits (447), Expect = 6e-43,   Method: Compositional matrix adjust.
 Identities = 92/220 (41%), Positives = 136/220 (61%), Gaps = 12/220 (5%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
           +V  V L  +P+ E      R+GE L +++++   W V+S  + +E ++P+ +VAKV HG
Sbjct: 25  EVDLVVLQDYPSAEVCEPIYRMGEKLKLVAQEAYGWRVRSVQTRQENYIPASHVAKVYHG 84

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL+EG+ R+KAEELL LPGN  G+F++RES   RG YSLSV+      +  ++HYRI RL
Sbjct: 85  WLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVK------YRSVKHYRIYRL 138

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
           DN W YISP LTF  L  ++ HY    DG+CC L  PC+   L   P   T PPV V   
Sbjct: 139 DNSWYYISPSLTFQCLEDMINHY---CDGLCCALTSPCLSASLPAPPTSATAPPV-VMRR 194

Query: 213 SLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLA 252
           +  W+K++R    L +  + + S+LS G+R S+++Y+S +
Sbjct: 195 NFTWQKVNRRQ--LTSVENCDDSVLSYGVRNSIAAYLSFS 232


>UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B0B45
          Length = 287

 Score =  161 bits (408), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 87/223 (39%), Positives = 131/223 (58%), Gaps = 30/223 (13%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
           +V  V L  +P+ E      R+GE L +++++   W V+S  + +E ++P+ +VAKV HG
Sbjct: 62  EVDLVVLQDYPSAEVCEPIYRMGEKLKLVAQEAYGWRVRSVQTRQENYIPASHVAKVYHG 121

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL+EG+ R+KAEELL LPGN  G+F++RES   RG YSLSV+      +  ++HYRI RL
Sbjct: 122 WLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVK------YRSVKHYRIYRL 175

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
           DN W YISP LTF  L  ++ HY + ADG+                      PPV V   
Sbjct: 176 DNSWYYISPSLTFQCLEDMINHYCDFADGL---------------------SPPV-VMRR 213

Query: 213 SLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDP 255
           +  W+K++R    L +  + + S+LS G+R S+++Y+S +E P
Sbjct: 214 NFTWQKVNRRQ--LTSVENCDDSVLSYGVRNSIAAYLSFSEGP 254


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  139 bits (350), Expect = 8e-32,   Method: Compositional matrix adjust.
 Identities = 76/171 (44%), Positives = 103/171 (60%), Gaps = 9/171 (5%)

Query: 29  PERH----KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSV 84
           P+ H    K   VAL  + A     L +  GE L ++   GDWW  +S V+GRE ++PS 
Sbjct: 52  PDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSN 111

Query: 85  YVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
           +VA+V       W +    R++AE  LL P N  G+FLIRES+T +G +SLSV+      
Sbjct: 112 FVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVK-DVTTQ 170

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
            + I+HY+I+ LD G  YISPR+TFPSL ALV+HYS+  DG+C  L  PCV
Sbjct: 171 GELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCV 221


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  138 bits (347), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 97/245 (39%), Positives = 131/245 (53%), Gaps = 31/245 (12%)

Query: 13  PSPSSSG--PDQ-EPVSMQPERHKVTA-----VALGSFPAGEQARLSLRLGEPLTIISE- 63
           P PS +G  P+Q  PV   PE     A     VAL  + A     LS R GE L I+++ 
Sbjct: 37  PMPSHAGQPPEQIRPVPQIPESETAGANAKIFVALYDYDARTDEDLSFRKGEHLEILNDT 96

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
            GDWW  +S+ +  E ++PS YVAK+    A  W +  + R +AE+ LLLP N  GAFLI
Sbjct: 97  QGDWWLARSKKTRSEGYIPSNYVAKLKSIEAEPWYFRKIKRIEAEKKLLLPENEHGAFLI 156

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           R+S++R   YSLSVR       D ++HYRI++LD G  +I+ R TF +L  LVEHYS+ +
Sbjct: 157 RDSESRHNDYSLSVR-----DGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDS 211

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSL---NWKKLDRSLLFLEAPASGEASL 236
           DG+C  L +PCV              PVT   S      W+    SL F+    SG+   
Sbjct: 212 DGLCVNLCKPCV----------QIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGD 261

Query: 237 LSEGL 241
           + EGL
Sbjct: 262 VWEGL 266


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  137 bits (344), Expect = 5e-31,   Method: Compositional matrix adjust.
 Identities = 73/159 (45%), Positives = 95/159 (59%), Gaps = 5/159 (3%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VAL  + A  +  LS   GE   I+ S +GDWW  +S  +G   ++PS YVA V    A 
Sbjct: 88  VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  L R+ AE  LL  GNP G FLIRES+T +G YSLS+R       D ++HY+I++
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           LDNG  YI+ R  F +L  LV+HYSE A G+CC L  PC
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPC 246


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  135 bits (340), Expect = 1e-30,   Method: Compositional matrix adjust.
 Identities = 66/170 (38%), Positives = 100/170 (58%), Gaps = 4/170 (2%)

Query: 25  VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSV 84
           V  + E  +   VAL  + A     L  + GE L II E G+WW  +S  + +E  +PS 
Sbjct: 55  VFQKMEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKARSLTTRKEGFIPSN 114

Query: 85  YVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
           YVA+        W Y+ ++R+ AE  LL P N  G++LIRES+T +G YSLS+R      
Sbjct: 115 YVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQG 174

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            D ++HY+I+ LDNG  YISP++TF  + ++++HY + +DG+C  L + C
Sbjct: 175 QDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKAC 224


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  134 bits (337), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 71/160 (44%), Positives = 102/160 (63%), Gaps = 10/160 (6%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VAL  + A     LS + GE L I+++  GDWW  +S+ + +E ++PS YVAK+    A 
Sbjct: 86  VALYDYDARTDEDLSFKKGEHLDILNDTQGDWWFARSKSTKQEGYIPSNYVAKLKSIEAE 145

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  + R +AE+ LLLP N  GAFL+R+S++RR  +SLSVR       D ++HYRI++
Sbjct: 146 PWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFSLSVR-----DGDTVKHYRIRQ 200

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
           LD G  +I+ R TF +L  LV+HY   ADG+C  LR+PCV
Sbjct: 201 LDEGGFFIARRTTFRTLQELVDHYGNEADGLCVNLRKPCV 240


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  133 bits (335), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 69/159 (43%), Positives = 95/159 (59%), Gaps = 5/159 (3%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VAL  + A     LS + GE   II+  +GDWW  +S  +G+  ++PS YVA      A 
Sbjct: 97  VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  + R+ AE LLL PGN  G FL+RES+T +G YSLS+R       D ++HY+I++
Sbjct: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           LDNG  YI+ R  F +L  LV+HY+E ADG+C  L   C
Sbjct: 217 LDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVC 255


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  132 bits (332), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 67/151 (44%), Positives = 92/151 (60%), Gaps = 4/151 (2%)

Query: 29  PERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           PE      VAL  +       LS + GE + ++ E G+WW  +S  + RE  +PS YVAK
Sbjct: 109 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLSTKREGFIPSNYVAK 168

Query: 89  V----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           V       W ++ ++R+ AE  LL PGN  GAFLIRES+T +G YSLSVR   P   D I
Sbjct: 169 VNTLETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDVI 228

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           +HY+I+ LDNG  YISPR+TFP +  ++++Y
Sbjct: 229 KHYKIRSLDNGGYYISPRITFPCISDMIKYY 259


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score =  130 bits (328), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 65/150 (43%), Positives = 89/150 (59%), Gaps = 4/150 (2%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVA----H 91
            +AL S+       L    GE L I+ + G+WW  QS  +G+E  +P  +VAK       
Sbjct: 124 VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPE 183

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W ++ LSR+ AE  LL PGN  G+FLIRES++  G +SLSVR       + ++HY+I+ 
Sbjct: 184 PWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRN 243

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADG 181
           LDNG  YISPR+TFP LH LV HY+   +G
Sbjct: 244 LDNGGFYISPRITFPGLHELVRHYTRYYNG 273


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  124 bits (311), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 75/192 (39%), Positives = 109/192 (56%), Gaps = 15/192 (7%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREYHMPSVYVA----KVAH 91
           VAL  + A     LS + GE L II + DGDWW  +S ++  E ++PS YVA      A 
Sbjct: 65  VALYDYEARISEDLSFKKGERLQIINTADGDWWYARSLITNSEGYIPSTYVAPEKSYEAE 124

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  + R +AE+ L++ G P G FLIR+++T  G +SLSVR       D ++HYR+++
Sbjct: 125 EWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLSVR-----DGDSVKHYRVRK 179

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
           LD G  +I+ R  F SL+ LV+HY++ ADG+ C L  PC   K  P+ G        +P 
Sbjct: 180 LDTGGYFITTRAPFNSLYELVQHYTKDADGLVCALTLPCPKDK--PVTGGIAKDAWEIPR 237

Query: 212 SSLNWKKLDRSL 223
            SL   +L+R L
Sbjct: 238 ESL---RLNRKL 246


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  122 bits (307), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 72/183 (39%), Positives = 102/183 (55%), Gaps = 10/183 (5%)

Query: 13  PSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQ 71
           P PS   P   P S  PE      VA+  +       L    GE + I+  +D +W+  +
Sbjct: 40  PYPSQYTP--PPSSPLPEN---LVVAIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAE 94

Query: 72  SEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG 127
           S  +G+  ++P  +VAK+       W Y+ LSR  A   LL PGN  G+FLIRES+T+ G
Sbjct: 95  SLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPG 154

Query: 128 CYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            +S+SVR   P   D I+HYRI+ +D G  YI+ +++F SL  LV+HYS  ADG+C  L 
Sbjct: 155 SFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLCTRLV 214

Query: 188 EPC 190
           +PC
Sbjct: 215 KPC 217


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  119 bits (298), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 59/159 (37%), Positives = 95/159 (59%), Gaps = 5/159 (3%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAKVA---H 91
            VA+ S+       L    G+ L II+ +D +W+  +S  +G+  ++P  ++A       
Sbjct: 55  VVAIYSYNPKHDGDLGFEKGDKLKIINKDDSEWYLAESLTTGQRGYIPYNFIAMSTMETE 114

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W ++ +SR +A   L+ PGN  G+FL+RES+T  G YSLS+R     + D ++HYRI+ 
Sbjct: 115 AWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMR-DFDNNGDGVKHYRIRN 173

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           +DNG  YI+ +++F SL  LV+HYS  +DG+C  L +PC
Sbjct: 174 MDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKLVKPC 212


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  118 bits (296), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 64/148 (43%), Positives = 94/148 (63%), Gaps = 11/148 (7%)

Query: 50  LSLRLGEPLTIISED-GDWWTVQS-EVSGREYHMPSVYVAKV----AHGWLYEGLSREKA 103
           LS + G+ + IIS D GDWW  +S + +G+E ++PS YVA+     A  W    + R +A
Sbjct: 73  LSFKKGDLMYIISTDEGDWWFARSKDTAGKEGYIPSNYVAEYKSLDAEEWFLGKIKRVEA 132

Query: 104 EELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRL 163
           E++L    N  G+FLIR+S+T  G +SLSV+       DR+RHYR++RL++G L+++ R 
Sbjct: 133 EKMLNQSFNQVGSFLIRDSETTPGDFSLSVK-----DQDRVRHYRVRRLEDGSLFVTRRS 187

Query: 164 TFPSLHALVEHYSELADGICCPLREPCV 191
           TF  LH LV+HY    DG+CC L  PC+
Sbjct: 188 TFQILHELVDHYKIETDGLCCKLLYPCL 215


>UniRef50_B7Z4J2 cDNA FLJ50391, highly similar to SRC-like-adapter n=2 Tax=Homo
           sapiens RepID=B7Z4J2_HUMAN
          Length = 249

 Score =  116 bits (290), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 71/221 (32%), Positives = 107/221 (48%), Gaps = 53/221 (23%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYE 96
             L  +P+ + +    R GE L +IS++G WW   S  +GRE ++P + VA+V HGWL+E
Sbjct: 45  AVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFE 104

Query: 97  GLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW 156
           GL R+KAEELL LP    G+F+IRES+T++                              
Sbjct: 105 GLGRDKAEELLQLPDTKVGSFMIRESETKK------------------------------ 134

Query: 157 LYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNW 216
                               E+ADG+CC L  PC+ Q       + +  PVT+   +++W
Sbjct: 135 --------------------EVADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDW 174

Query: 217 KKLDR---SLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
           +++ R        E P   + SL S GLRES++SY+SL  +
Sbjct: 175 RRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLTSE 215


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  114 bits (284), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 73/209 (34%), Positives = 109/209 (52%), Gaps = 24/209 (11%)

Query: 37  VALGSFPA-GEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VAL  + A  E+     R  E L +   D +WW VQ+  SGR+ ++PS +VAK     A 
Sbjct: 118 VALFDYNARTEEETFLSRRDEVLLLADTDSEWWLVQNLSSGRKGYVPSSFVAKKGSVEAE 177

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR---PASWDRIRHYR 148
            W    LSR+ +E LLLL GN  G FL+RES+T +G  +LSVR          + ++HYR
Sbjct: 178 EWFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTVKHYR 237

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I+  D  + YI+ + +F SL  L++ YS  + G+CC L   C+            PPP+T
Sbjct: 238 IKHPDYRYYYITTKCSFSSLQELIQFYSIDSHGLCCKLTRACL-----------CPPPIT 286

Query: 209 ----VPTSSLNWKKLDRSLLFLEAPASGE 233
               V T   +W+    S++ +E   +G+
Sbjct: 287 SDLSVKTKD-HWEISKSSIVLIEKLGAGQ 314


>UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californica
           RepID=B6DVV3_APLCA
          Length = 517

 Score =  112 bits (280), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 71/200 (35%), Positives = 113/200 (56%), Gaps = 18/200 (9%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G +     + + SPS+ G    P+   P R++V A  L +F A  Q  LS R G+ + I 
Sbjct: 32  GRVDLNASSGTSSPSTDG--LRPLPRVPARNRVRA--LYNFEAINQDDLSFRKGDLMEID 87

Query: 62  S---EDGDWWTVQSEVSGREYHMPSVYVAK-----VAHGWLYEGLSREKAEELLLLPGNP 113
               E  DWW      +  + ++PS YVAK         W +E   R++++++LLLPGNP
Sbjct: 88  ETSPETDDWWLAVHLKTKNKGYIPSNYVAKDDATPQTQDWWFE-FDRKESDKMLLLPGNP 146

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWD-RIRHYRIQRLDN--GWLYISPRLTFPSLHA 170
            G FL+RE+ T +  Y LSVR +  AS +  ++HYR++++D+  G+ +IS + TF +L  
Sbjct: 147 RGTFLVREA-TDKSTYVLSVRDNDKASGEPCVKHYRVRKMDDERGY-FISAKKTFKTLFD 204

Query: 171 LVEHYSELADGICCPLREPC 190
           ++EHY + +DG+CC L   C
Sbjct: 205 VIEHYKDNSDGLCCQLGAAC 224


>UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QLS5_SCHMA
          Length = 801

 Score =  110 bits (275), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 61/156 (39%), Positives = 90/156 (57%), Gaps = 8/156 (5%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VA+  + A     +S R G+ L ++   D +WW V  E SG+  ++PS Y+A+     A 
Sbjct: 339 VAIFDYEAHTSEEVSARKGDQLRVLDLSDSEWWLV--EHSGQVGYIPSSYLAQANSVEAE 396

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI-Q 150
            W +  +SR+ +E LLLL GN  G FL+R S+T  G  SLSVR +     + ++HY+I Q
Sbjct: 397 DWYFRSISRKDSERLLLLKGNIRGTFLVRASETTNGALSLSVRDTEQQRGETVKHYKIKQ 456

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
             +   +YI+ +  FP L +LV HYS  ADG+CC L
Sbjct: 457 SSETNDVYITTKQVFPDLKSLVIHYSNQADGLCCCL 492


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  107 bits (266), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 70/227 (30%), Positives = 116/227 (51%), Gaps = 26/227 (11%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGR--------EY 79
           Q +RH    VAL  + A     LS R G+ L ++    + W     +  R        + 
Sbjct: 39  QSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQG 98

Query: 80  HMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
           ++PS YVA+     A  W +  + R  AE+ LL   N  G+FLIRES++++G +SLSV  
Sbjct: 99  YIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSV-- 156

Query: 136 SRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKL 195
                   ++HYRI+RLD G  +++ R  F +L+  V HY++ +DG+C  L +PC+  ++
Sbjct: 157 ---LDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQV 213

Query: 196 GPLPGKDTPPPVTVPTSSLNWKKLDR-SLLFLEAPASGEASLLSEGL 241
                   P P  +   +++  ++DR S+  L+   SG+   + EGL
Sbjct: 214 --------PAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGL 252


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  105 bits (263), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 71/208 (34%), Positives = 107/208 (51%), Gaps = 22/208 (10%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQ--------------EPVSMQPERHKVTAVALGSFPAGEQ 47
           GSL SR    +P P+  GP +               P  +     K   VAL  + + ++
Sbjct: 55  GSLDSR---YTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDE 111

Query: 48  ARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREK 102
           + LS   G+ + +I + + DWW V +  + +E  +P  +VA+     +  W +E + R++
Sbjct: 112 SDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKE 171

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR 162
           A++LLL   NP G FL+R S+     YSLSV+         ++HYRI+ LDNG  YI+  
Sbjct: 172 ADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATN 231

Query: 163 LTFPSLHALVEHYSELADGICCPLREPC 190
            TFPSL ALV  YS+ A G+C  L  PC
Sbjct: 232 QTFPSLQALVMAYSKNALGLCHILSRPC 259


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score = 97.8 bits (242), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 57/164 (34%), Positives = 89/164 (54%), Gaps = 13/164 (7%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
             VA+  + A     L+   G+ L I  +  DWW  +S  +G++ ++P  YVA +    A
Sbjct: 67  VVVAVYDYDARLDDDLTFVKGDLLEIREDTTDWWYARSRKNGKKGYIPGNYVAPIQTLEA 126

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG----CYSLSVRLSRPASWDRIRH 146
             W +  + R  AE+LL+  G+  G+FLIR+S+ + G    C++LSVR       + IRH
Sbjct: 127 EPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVR-----DKELIRH 181

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           YRI+  D+G  +IS    F +L+ L+E Y   +DG+   L EPC
Sbjct: 182 YRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIKLLEPC 225


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 69/190 (36%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWT 69
           S+ SP  SG    P+        V   AL S+    Q  LS + G+ + +IS   D WW 
Sbjct: 100 STVSPGGSGVQARPL--------VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWF 151

Query: 70  VQSEVSGREYHMPSVYVA------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +   +G   ++PS YV            W    + R +A+  LLL GNP G +LIR S 
Sbjct: 152 ARHSDTGISGYIPSNYVCLNDGLPTSLDAWY--NIGRREADRKLLLVGNPQGTYLIRPSS 209

Query: 124 TRRGCYSLSVRL--SRPASWDRIRHYRIQRLDN-GWLYISPRLTFPSLHALVEHYSELAD 180
             +  Y+LSVR   S    W  ++HYRI+ LDN G  +IS R TFP++  LV +Y+   D
Sbjct: 210 ETQN-YALSVRHYDSEKNMW-VVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPD 267

Query: 181 GICCPLREPC 190
           G+CC L  PC
Sbjct: 268 GLCCRLSIPC 277


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score = 95.5 bits (236), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 69/190 (36%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWT 69
           S+ SP  SG    P+        V   AL S+    Q  LS + G+ + +IS   D WW 
Sbjct: 16  STVSPGGSGVQARPL--------VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWF 67

Query: 70  VQSEVSGREYHMPSVYVA------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +   +G   ++PS YV            W    + R +A+  LLL GNP G +LIR S 
Sbjct: 68  ARHSDTGISGYIPSNYVCLNDGLPTSLDAWY--NIGRREADRKLLLVGNPKGTYLIRPSS 125

Query: 124 TRRGCYSLSVRL--SRPASWDRIRHYRIQRLDN-GWLYISPRLTFPSLHALVEHYSELAD 180
             +  Y+LSVR   S    W  ++HYRI+ LDN G  +IS R TFP++  LV +Y+   D
Sbjct: 126 ETQN-YALSVRHYDSEKNMW-VVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPD 183

Query: 181 GICCPLREPC 190
           G+CC L  PC
Sbjct: 184 GLCCRLSIPC 193


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 60/195 (30%), Positives = 96/195 (49%), Gaps = 10/195 (5%)

Query: 5   SSRGKTSSPSPSS---SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           SS      P+ SS   S PDQ P        +++ +AL +F       LS   GE L + 
Sbjct: 19  SSNATQPKPNISSNFQSKPDQPPPVPW-RPPEMSYIALYAFQGRNDGDLSFEKGEVLKVF 77

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAF 117
            + GDWW   S  +  + ++P  YVA V      GW +   +R +A   L     P G F
Sbjct: 78  DQSGDWWVASSTRTNVQGYIPCNYVAPVNSLEVEGWFFGSCTRSEAIMRLQADNLPKGTF 137

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNG--WLYISPRLTFPSLHALVEHY 175
           L+RES+TR G Y+L+VR +       I++YR+ +  +G    +I+P+  F ++  +V+ +
Sbjct: 138 LVRESETRPGTYALTVRETDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVIDVVKFH 197

Query: 176 SELADGICCPLREPC 190
           +    G+C  L +PC
Sbjct: 198 TSQPGGLCSKLLKPC 212


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 61/192 (31%), Positives = 101/192 (52%), Gaps = 8/192 (4%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV---- 89
           T VAL  + +     LS + G+ + ++   + DWW V+ + +G+  ++P  +VAK     
Sbjct: 75  TLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIE 134

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA-SWDRIRHYR 148
           +  W    + R +AE L+L    P G FLIRE +     ++L++R +    +   ++HY+
Sbjct: 135 SEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYK 194

Query: 149 IQRLDNGWLY-ISPRLTFPSLHALVEHYSELADGICCPLREPC-VLQKLGPLPGKDTPPP 206
           I+RLD+   Y I+ R TF SL  LV +YS++ DG+CC L  P   L    P    DT   
Sbjct: 195 IKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQN 254

Query: 207 VTVPTSSLNWKK 218
             +P + L+ K+
Sbjct: 255 WEIPRNQLHLKR 266


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 56/166 (33%), Positives = 87/166 (52%), Gaps = 16/166 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VAL  +       L++  G+   I+ +   DWW  +   +G   ++P  ++A V    ++
Sbjct: 161 VALHDYVKRVDDDLNMTKGQIFNILDNSHCDWWYAECVSTGNRGYVPKNHLAAVTSLESN 220

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ- 150
            W +  L R +AE  L LPGN  G+FL+R S+++   YSLSVR       + ++HYRI+ 
Sbjct: 221 EWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVR-----EENTVKHYRIRS 275

Query: 151 ---RLDNGW--LYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
              R D      YIS +L F ++  LV HY E   G+CC L +PC+
Sbjct: 276 RYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPCI 321


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 60/188 (31%), Positives = 91/188 (48%), Gaps = 21/188 (11%)

Query: 38  ALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQS-EVSGREYH---MPSVYVAKVAHG- 92
           AL +F + +   LS R G+   ++S   DWW+V+  + SGR      +P  Y+A    G 
Sbjct: 6   ALWAFQSQQGEHLSFREGDLFRVLSRRDDWWSVRRIDASGRVLDSGLVPGNYLAPAESGQ 65

Query: 93  ---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W +  L+R +A+  LL P N  GAFLIR S+     Y LSVR     S D+++HY++
Sbjct: 66  TQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVR-----SGDQVKHYKV 120

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
            + D    Y+ P   F SL  LV++Y + +     PL  PC    L          P  +
Sbjct: 121 LQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLS--------TPALL 172

Query: 210 PTSSLNWK 217
           P  ++ W+
Sbjct: 173 PFPTIGWE 180



 Score = 69.3 bits (168), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 5/102 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W Y  ++R KAE+LLL   N  G+FL+R S++    Y++S R     S  ++ H+RIQR 
Sbjct: 250 WYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISAR-----SEGKVFHFRIQRS 304

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
             G  ++S R++F +L  L+ +Y      +   L EPC  Q+
Sbjct: 305 SIGAYFVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQR 346



 Score = 57.4 bits (137), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 13/108 (12%)

Query: 110 PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLH 169
           P N  GAFLIR S+     Y LSVR     S D+++HY++ + D    Y+ P   F SL 
Sbjct: 731 PENSEGAFLIRVSEKDNVGYVLSVR-----SGDQVKHYKVLQTDQNRFYVEPGRRFSSLA 785

Query: 170 ALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWK 217
            LV++Y + +     PL  PC    L          P  +P  ++ W+
Sbjct: 786 ELVDYYQKTSLNNAGPLGNPCKRNTLS--------TPALLPFPTIGWE 825


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 55/168 (32%), Positives = 92/168 (54%), Gaps = 12/168 (7%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           VAL +F +  +A LS   GE L ++S  DG WW V+S ++ +  ++P+ YV K      +
Sbjct: 39  VALFNFTSNNEAELSFSCGEQLELLSISDGSWWKVRSLLTNKIGYIPNNYVEKYDYLKKY 98

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W Y G+    +  L LL     G+FL+R+S ++ G Y+LS+      +   ++HY I++
Sbjct: 99  DW-YTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGDYTLSLH-----NETSLKHYHIKK 152

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLP 199
             N   YI     F +L +LVEHY +++ G+   L++ C  +KL  +P
Sbjct: 153 TKNCTFYILKE-EFSNLPSLVEHYKKVSGGLPRTLKDACSQKKLWDIP 199


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score = 87.4 bits (215), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 64/196 (32%), Positives = 100/196 (51%), Gaps = 17/196 (8%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISED--GDWWTVQSEVSGREYHMPSVYVAKVA-- 90
           T VAL     G    + LR G+ L  +++D   +W  V++ V+G +  +P+ ++A  A  
Sbjct: 173 TFVALYDHTPGCAKEMLLRAGDMLLRVNKDPSKEWTLVENCVTGCQGFVPTSFIAASASL 232

Query: 91  --HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
             H W +  ++R KAE+ L  P    G+FLIRES++  G YSLS+R       D +RHYR
Sbjct: 233 ESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLR-----DGDTVRHYR 287

Query: 149 IQRLDNGWLYI--SPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK---DT 203
           ++  + G   +  SP   F SL  L+  + +   G+   LREPC  ++  P+      DT
Sbjct: 288 VENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATALREPCP-KESAPMASDLTFDT 346

Query: 204 PPPVTVPTSSLNWKKL 219
                VP +S+   KL
Sbjct: 347 HDQWEVPRTSIKLGKL 362


>UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RNL0_TETNG
          Length = 509

 Score = 84.3 bits (207), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 55/160 (34%), Positives = 76/160 (47%), Gaps = 36/160 (22%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           +AL  + A  +  LS R GE   II+  +GDWW  +S  +G   ++PS YVA V    A 
Sbjct: 7   IALYDYDARTEDDLSFRKGEKFHIINNTEGDWWEARSLDTGNSGYIPSNYVAPVDSIQAE 66

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR------------------------- 126
            W +  + R+ AE  LL  GN  G FLIRES+T +                         
Sbjct: 67  EWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYVGYTSVP 126

Query: 127 ------GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYIS 160
                 G YSLS+R       D ++HY+I++LDNG  YI+
Sbjct: 127 LHSRFPGAYSLSIRDWDDNKGDHVKHYKIRKLDNGGYYIT 166


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score = 83.2 bits (204), Expect = 7e-15,   Method: Compositional matrix adjust.
 Identities = 66/199 (33%), Positives = 98/199 (49%), Gaps = 18/199 (9%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPER----HKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           G+    +P S  P+ +PV   P           +AL  F A     LS+R G+ L  + E
Sbjct: 24  GEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCAL-E 82

Query: 64  DGDWWTVQSEVSGREYH--MPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGG 115
           +G  +     +SG+     +P  +VAK +        W + G+SR +A++LLL P N  G
Sbjct: 83  EGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPG 142

Query: 116 AFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           AFLIR S++  G YSLSVR     +  ++ HYR+    +G LY+     FP L  L+ +Y
Sbjct: 143 AFLIRPSESSLGGYSLSVR-----AQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYY 197

Query: 176 SELADGICCPLREPCVLQK 194
                 I  PL +PC+ QK
Sbjct: 198 KANWKLIQNPLLQPCMPQK 216


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score = 82.4 bits (202), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 60/166 (36%), Positives = 86/166 (51%), Gaps = 16/166 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG + +LSLR GE + I+S  + G+W    S+ SG    +PS YV  +     
Sbjct: 136 VALYDFKAGGENQLSLRKGEQVRILSYNKSGEWCEAHSD-SGHVGWVPSNYVTPLNSLEK 194

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 195 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYD-----GRVYHYRIS 247

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELAD--GICCPLREPCVLQK 194
              +G +Y++    F +L  LV H+S L +  G+  PL  P   Q 
Sbjct: 248 EDSDGKVYVTAEAKFNTLAELVHHHSVLHEGHGLITPLLYPAPKQN 293


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score = 82.0 bits (201), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 72/240 (30%), Positives = 105/240 (43%), Gaps = 38/240 (15%)

Query: 41  SFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAHG------ 92
            F    +  L  + G+ LTI   +ED +WW V+ + +GR   +P+ YV  +         
Sbjct: 29  DFNGASKEDLPFKKGDILTIENPTEDPNWWLVRDK-TGRTGMIPANYVELIGSDTKKTGT 87

Query: 93  -------------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
                        W +  +SRE AE LL+      G FL+RES    G Y+L V      
Sbjct: 88  LPRDASGQLIPMPWFHGKISRELAESLLM--PREDGLFLVRESAHFPGDYTLCVCFQ--- 142

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLP 199
             D++ HYR+Q   NG L I   + F SL  LV+HY + ADG+C  LR+P V Q      
Sbjct: 143 --DQVDHYRMQG-KNGKLTIDEEVYFSSLEELVQHYEKDADGLCTRLRKPVVKQ-----G 194

Query: 200 GKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
           G++           +NW+   R ++      SG+   + EGL       I   +D   DA
Sbjct: 195 GREFKIDA---RKFVNWEISPREIVKSAQIGSGQFGDVFEGLYRGQKVAIKTLKDVQGDA 251


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score = 80.9 bits (198), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 67/230 (29%), Positives = 108/230 (46%), Gaps = 26/230 (11%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F A     LS+  GE L ++  + +G+W   Q++ +G+ + +PS Y+  V     
Sbjct: 67  VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 124

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 125 HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 177

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
              +G LY+S    F +L  LV H+S +ADG+   L  P         P ++ P    V 
Sbjct: 178 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA--------PKRNKPTVYGVS 229

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYI---SLAEDPLD 257
            +   W+     +        G+   + EG+ +  S  +   +L ED ++
Sbjct: 230 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME 279


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score = 80.5 bits (197), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 84/160 (52%), Gaps = 15/160 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F A     LS+  GE L ++  + +G+W   Q++ +G+ + +PS Y+  V     
Sbjct: 406 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 463

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 464 HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 516

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
              +G LY+S    F +L  LV H+S +ADG+   L  P 
Sbjct: 517 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA 556


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score = 80.5 bits (197), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 48/155 (30%), Positives = 82/155 (52%), Gaps = 6/155 (3%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPS--VYVAKVAHGWL 94
           V++  +     + +  + GE   ++    DW  VQSE SG + ++PS  + +      W 
Sbjct: 10  VSISEYNPKHNSDIPCKGGEAFYLLERTDDWCYVQSETSGSKGYLPSHLIQLDLTNEPWF 69

Query: 95  YEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDN 154
           +  + R +AE LL    +  G FLIRES+T +G Y+L++   +  +  +I H+RI   D+
Sbjct: 70  HGNIGRIEAENLLQY--SEPGTFLIRESETIKGSYTLTMIQIKDGT-KQISHFRIN-YDD 125

Query: 155 GWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           G  +I+    F  LH L++HY + +DG+ C L  P
Sbjct: 126 GKYFITSARRFLGLHQLIQHYMQNSDGLACNLVYP 160


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score = 80.1 bits (196), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 54/179 (30%), Positives = 91/179 (50%), Gaps = 15/179 (8%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA 87
           +P+      +A+  +P  E+  L L  G+ +T+     ++W    +  G E ++PS YV 
Sbjct: 250 EPKPSDFDVIAMYDYPGLERGDLPLVKGQRVTVFDATREFWWRARDEQGSEGYIPSNYVK 309

Query: 88  KV---AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           K+   +  W +  LSR +AE +L   G  GG F++R S +R   Y+LS+         ++
Sbjct: 310 KMGLDSEEWFFPQLSRTRAENILKGEGREGG-FVVRNS-SRENMYTLSI-----CHEGQV 362

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL-----QKLGPL 198
           RHY I+  ++   +IS +  FPS+  L+E++     G+   LR+P V      Q LGPL
Sbjct: 363 RHYHIKLDESNKYFISEKHRFPSIKELIEYHKLNGGGLVTRLRKPPVQLAPNPQSLGPL 421


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score = 79.7 bits (195), Expect = 8e-14,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 84/160 (52%), Gaps = 15/160 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F A     LS+  GE L ++  + +G+W   Q++ +G+ + +PS Y+  V     
Sbjct: 319 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 376

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE LL       G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 377 HSWYHGPVSRNAAEHLL--SSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 429

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
              +G LY+S    F +L  LV H+S +ADG+   L  P 
Sbjct: 430 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA 469


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 56/160 (35%), Positives = 87/160 (54%), Gaps = 15/160 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F A     LS+  GE L ++  +++G+W  V+S+ +G+ + +PS Y+  V     
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 170

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 223

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
              +G +Y++    F +L  LV H+S +ADG+   L  P 
Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPA 263


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score = 79.0 bits (193), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 58/190 (30%), Positives = 96/190 (50%), Gaps = 18/190 (9%)

Query: 10  TSSPSPSSSGPDQEPVSMQPERH----KVTAVALG--SFPAGEQARLSLRLGEPLTIISE 63
            ++  PS  G  Q   S + +R+    +V  V +G  +F    +  LS   GE LT++  
Sbjct: 34  AAAAGPSQPGSRQRQPSHRADRYPREPQVGDVFVGVYNFQGRTEPELSFERGEKLTLLRR 93

Query: 64  -DGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFL 118
            D +WW ++S+ SG+E + PS Y+A       + W +  +SR  AE   LL     G+FL
Sbjct: 94  LDENWWLMRSQRSGKEGYAPSNYIAPFKDINRNPWYHSNISRNTAE--YLLKSGVDGSFL 151

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           +RES +  G YS+++R    A      HYRI     G+   + +  F ++  LV H++ +
Sbjct: 152 VRESLSSPGEYSITLRCDGKAR----THYRINHDARGYFVAAGKF-FATVEQLVAHHAVV 206

Query: 179 ADGICCPLRE 188
           ADG+   L++
Sbjct: 207 ADGLVACLKQ 216


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score = 78.6 bits (192), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 50/142 (35%), Positives = 79/142 (55%), Gaps = 10/142 (7%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVA   F A  +  LS   G+ L I+S   +W+  ++E+  +E ++P  ++      W
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWF--KAELGSQEGYVPKNFIDIQFPKW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR       D ++H+++ R D
Sbjct: 59  FHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHE-----DDVQHFKVMR-D 110

Query: 154 NGWLYISPRLTFPSLHALVEHY 175
           N   Y      FPSL+ LV++Y
Sbjct: 111 NKGNYFLWTEKFPSLNKLVDYY 132


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score = 77.4 bits (189), Expect = 5e-13,   Method: Compositional matrix adjust.
 Identities = 55/187 (29%), Positives = 88/187 (47%), Gaps = 15/187 (8%)

Query: 14  SPSSSGPDQEPVSMQPERH---KVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWW 68
           S S SG    P+S    ++       VA   F    +  L  + G+ + I+  + D +W+
Sbjct: 2   SNSMSGNSGNPMSGNSSKNFPNGTECVARYDFKGNSEKDLPFKKGDIIEILQSTRDPNWY 61

Query: 69  TVQSEVSGREYHMPSVYVA--KVAHG----WLYEGLSREKAEELLLLPGNPGGAFLIRES 122
             +    GR   +P  YV   +  H     W +  ++REKAEELL       G FL+RES
Sbjct: 62  NAKKVSDGRTGLIPINYVQQRRALHLHEMPWFFGKITREKAEELL--TPREVGLFLVRES 119

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
               G Y+L V    P +  ++ HYR+    +  + +     FP+L  L++HY + ADG+
Sbjct: 120 TNFPGDYTLCV--VSPQNNKKVEHYRVISTSDNQVTVDEEAFFPTLIELIKHYEKDADGL 177

Query: 183 CCPLREP 189
           C  L++P
Sbjct: 178 CTMLKKP 184


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score = 77.0 bits (188), Expect = 6e-13,   Method: Compositional matrix adjust.
 Identities = 61/211 (28%), Positives = 100/211 (47%), Gaps = 22/211 (10%)

Query: 38  ALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV---AHGW 93
           +L  + A E   LSL  GE L I+ + +  WW  ++  +G+E ++P+ YV K+   +  W
Sbjct: 224 SLYDYDALEPTDLSLSKGERLVIVDQMEEHWWKARNN-AGQEGYIPANYVRKLGLESEPW 282

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
                S+  A  LL + G   GAFL+RES++  G YSLSV         +++HY+I+  D
Sbjct: 283 FMADTSKAMASALLNMCGQD-GAFLVRESESTPGSYSLSVFYQ-----GKLKHYKIKH-D 335

Query: 154 NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS 213
                +S R TF S+  L+E++     G+   LR+P           +D   P+T     
Sbjct: 336 QDMYRVSERHTFASISELIEYHKHNGGGLVTRLRKPV----------QDANTPITAGLGH 385

Query: 214 LNWKKLDRSLLFLEAPASGEASLLSEGLRES 244
             W+   R +       SG   ++  G+ +S
Sbjct: 386 DRWELDAREIELGRELGSGNFGVVRAGVYKS 416


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score = 76.3 bits (186), Expect = 8e-13,   Method: Compositional matrix adjust.
 Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG + +LSL+ GE + I+S  + G+W    S+ SG    +PS YV  +     
Sbjct: 212 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEK 270

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 271 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYD-----GRVYHYRIS 323

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQK 194
              +G ++++    F +L  LV H+S      G+  PL  P   Q 
Sbjct: 324 EDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQN 369


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score = 76.3 bits (186), Expect = 9e-13,   Method: Compositional matrix adjust.
 Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG + +LSL+ GE + I+S  + G+W    S+ SG    +PS YV  +     
Sbjct: 201 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEK 259

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 260 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIS 312

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQK 194
              +G ++++    F +L  LV H+S      G+  PL  P   Q 
Sbjct: 313 EDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQN 358


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score = 76.3 bits (186), Expect = 9e-13,   Method: Compositional matrix adjust.
 Identities = 58/178 (32%), Positives = 91/178 (51%), Gaps = 23/178 (12%)

Query: 20  PDQEPVS-MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQ----SE 73
           P QEPV    P   KVTAV    +    ++ L L+ G+   I  SE+ +WW  Q    S+
Sbjct: 101 PKQEPVKCFIPINTKVTAVY--DYQPKSKSELQLKQGDVFVITNSENENWWEAQPVGNSD 158

Query: 74  VSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
           + G    +PS YV K+    +  + +  + R  AE    L     G+FL+RESQ+  G +
Sbjct: 159 IVG---WVPSNYVVKLNSLDSEPYYHGRIPRTTAE--FFLSNGINGSFLVRESQSNAGEH 213

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
           ++S+R        ++ HYRI R D G ++I+    F ++  LV+ Y + +DG+  PLR
Sbjct: 214 TISLRCD-----GKVFHYRISRTDKG-VFIAADRVFSTVQDLVKFYHQQSDGLVHPLR 265


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score = 76.3 bits (186), Expect = 9e-13,   Method: Compositional matrix adjust.
 Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG + +LSL+ GE + I+S  + G+W    S+ SG    +PS YV  +     
Sbjct: 192 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEK 250

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 251 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIS 303

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQK 194
              +G ++++    F +L  LV H+S      G+  PL  P   Q 
Sbjct: 304 EDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQN 349


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score = 76.3 bits (186), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 16/166 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG + +LSL+ GE + I+S  + G+W    S+ SG    +PS YV  +     
Sbjct: 193 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEK 251

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 252 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIS 304

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQK 194
              +G ++++    F +L  LV H+S      G+  PL  P   Q 
Sbjct: 305 EDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQN 350


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score = 75.1 bits (183), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 37/99 (37%), Positives = 55/99 (55%), Gaps = 3/99 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +   SR+ AE+ L+  G   G F++R+     G + LSVR + P   D ++HYRI ++
Sbjct: 7   WDFGMCSRQDAEKKLMAIGINKGQFIVRDRDP--GTFELSVRDNNPQKGDHVKHYRIWKM 64

Query: 153 DNGW-LYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           D G   +I     FP++  LV HY   +DG+CC L E C
Sbjct: 65  DGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEAC 103


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score = 75.1 bits (183), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 49/175 (28%), Positives = 87/175 (49%), Gaps = 19/175 (10%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           V L  F  G + +L++R G+ + I+  ++ G+W   +   +G+   +P  YV        
Sbjct: 125 VVLYDFNGGVENQLTVRKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPVTYVTPFNSLEK 184

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+R+S++  G  S+S+R        R+ HYRI 
Sbjct: 185 HSWYHGPISRNAAE--YLLSSGIDGSFLVRDSESSPGHRSISLRFD-----GRVYHYRIS 237

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC------VLQKLGPLP 199
              +G ++++    F ++  LV H+ + +DG+   LR P       ++  + PLP
Sbjct: 238 SGSDGKVFVTTESKFSTIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLP 292


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score = 75.1 bits (183), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 59/175 (33%), Positives = 88/175 (50%), Gaps = 23/175 (13%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG   +LSL+ GE + I+S  + G+W    +   G+   +PS YV  V     
Sbjct: 113 VALYDFQAGGDNQLSLKKGEQVRILSYNKSGEWCEAHAS-PGQVGWVPSNYVTPVNSLEK 171

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI- 149
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 172 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 224

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           +   +G +Y++    F +L  LV H+S  +DG+        + Q L P P  + P
Sbjct: 225 EDTSDGKVYVTTESRFNTLAELVHHHSMHSDGL--------ITQLLYPAPKHNKP 271


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score = 74.3 bits (181), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 57/190 (30%), Positives = 96/190 (50%), Gaps = 16/190 (8%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVS--MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           L+S    S  SP+S  P   PV+  + PER +V    +  + A     L++   E +TI+
Sbjct: 253 LASMRGPSGASPTSPAPASSPVAPAVVPERKQVRV--MFDYIATAAGDLTIHKDEMITIL 310

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAF 117
            E  +WW  Q++  G    +PS Y+ ++       W    +SR +A  +L +    G  F
Sbjct: 311 EERPNWWKAQNK-HGEVGFVPSNYLCRIQGLEGEPWFRGRISRAEAAAMLQITKQEG-CF 368

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           L+RES+T+ G Y+LS+  +     + +RHYRIQ ++ G  +++    F S+  L+E++  
Sbjct: 369 LVRESETQPGEYTLSLSHN-----EGVRHYRIQHIE-GQYFVNENHRFDSIPQLIEYHKL 422

Query: 178 LADGICCPLR 187
              GI   LR
Sbjct: 423 NGGGIVTRLR 432


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score = 74.3 bits (181), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 23/179 (12%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAK---VA 90
            +A  +F    +  L    G+ LTI+  ++D +W+  +++V GRE  +P+ YV K   V 
Sbjct: 14  CIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVK 72

Query: 91  HG-------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
            G       W +  ++RE+AE LL  P    G FL+RES    G Y+L V         +
Sbjct: 73  AGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCD-----GK 125

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           + HYRI    +  L I   + F +L  LVEHY+  ADG+C  L +P V++  G +  +D
Sbjct: 126 VEHYRIMYHASK-LSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVME--GTVAAQD 181


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score = 73.2 bits (178), Expect = 7e-12,   Method: Compositional matrix adjust.
 Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 26/201 (12%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDG 65
           GK     P + GP  E  S+    +  T   +  F  G +  L  + G+ L +I  + D 
Sbjct: 7   GKLIDTGPVTRGPSYENHSLTTIPNGTTCEGVFDFNTGNKGDLPFKKGDTLVVIQRTRDP 66

Query: 66  DWWTVQSEVSGREYHMPSVYVAK---------------VAHGWLYEGLSREKAEELLLLP 110
           +W+  Q+   G    +P  Y+ +                A  W +  ++R  AE+LL   
Sbjct: 67  NWYRAQNS-KGESGMVPLNYITQSNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLL--T 123

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHA 170
               G FL+RES    G Y++ V  +       + HYR+   DN  + I     F +L  
Sbjct: 124 PRKDGLFLVRESTNYPGDYTMCVSFA-----GEVEHYRVIFKDNK-VTIDEEEYFENLTK 177

Query: 171 LVEHYSELADGICCPLREPCV 191
           LVEHY   ADG+ C L +P +
Sbjct: 178 LVEHYERDADGLVCTLTQPLI 198


>UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RJ03_TRIAD
          Length = 235

 Score = 72.8 bits (177), Expect = 9e-12,   Method: Compositional matrix adjust.
 Identities = 45/114 (39%), Positives = 64/114 (56%), Gaps = 13/114 (11%)

Query: 81  MPSVYVAKVAH---GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           M S+YV        GW + GLSR   +++L    N  G+F +R S T  G +SLSV+  +
Sbjct: 1   MASLYVYDYQDQFDGWFFTGLSRGDIDKMLYKKVNQQGSFAVRPSDTYLGDFSLSVKDGK 60

Query: 138 PASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
                RI HY I+RL +G   IS R+TFPSL +LV +Y +  +G+     +PCV
Sbjct: 61  -----RICHYLIRRLCSGHFLISVRVTFPSLLSLVTYYVDDNNGL-----KPCV 104



 Score = 52.4 bits (124), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 35/101 (34%), Positives = 58/101 (57%), Gaps = 7/101 (6%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           + Y  + R  AE+LLL     G   FLIR+S++ +G ++LSV+ +     D I H+R+  
Sbjct: 138 YYYGEMKRADAEKLLLSESVDGCNLFLIRKSESYKGEFALSVKEN-----DDILHFRLPE 192

Query: 152 LDNGWLYISPR-LTFPSLHALVEHYSELADGICCPLREPCV 191
           L    L I+ + + F SL  LV+++S  ++G+C  L +P V
Sbjct: 193 LQQDSLIIARKYIEFISLDDLVQYFSLNSNGLCAKLTKPGV 233


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score = 72.4 bits (176), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 41/99 (41%), Positives = 58/99 (58%), Gaps = 9/99 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD-RIRHYRIQR 151
           W +  +SRE AE+LL  P N  G FL+RESQ   G Y+L V      S+D R+ +YR++R
Sbjct: 109 WFHGRISREDAEKLLTPPKN--GRFLVRESQNYPGDYTLCV------SYDGRVENYRVRR 160

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            + G + +     F +L  LVEHY + ADG+C  L+ P 
Sbjct: 161 NEKGLVTVDDDEYFDNLIKLVEHYQKEADGLCTRLKAPV 199


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score = 72.0 bits (175), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 54/165 (32%), Positives = 80/165 (48%), Gaps = 18/165 (10%)

Query: 38  ALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV-----QSEVSGREYHMPSVYVAK---- 88
           AL S+ A     LS + GE   I    G+WWT         V+GR + +P+ ++A+    
Sbjct: 60  ALWSYKARGADELSFQEGEQFRICERQGEWWTALKLGRDGAVTGRGF-VPNHFLARRQTV 118

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR---IR 145
               W +  L+R + E LLL P N  GAFL+R S+     Y LSV      S DR   ++
Sbjct: 119 KEQPWYFGTLNRFETEILLLAPENDVGAFLVRHSEKDNIGYVLSV-----LSGDRSREVK 173

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           H +I +  N   Y+    TF SL  LV++Y + +      L++PC
Sbjct: 174 HIKIHQNQNESFYLDKSQTFQSLEKLVDYYWKYSLDGDSFLKQPC 218


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score = 72.0 bits (175), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 62/228 (27%), Positives = 105/228 (46%), Gaps = 25/228 (10%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWTVQSEVSGREYHMPSVYVAKVA---- 90
            VAL  F A E   LSL       +I +  + WW V+  +    Y +PS YV   A    
Sbjct: 347 VVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGY-IPSNYVKPKALLGL 405

Query: 91  --HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
             + W    +SR++AE  LL  G+  G F++R+S T +G Y+LS+    P S   ++HY 
Sbjct: 406 ERYEWYVGDMSRQRAES-LLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQS--HVKHYH 461

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR-EPCVLQKLGPLPGKDTPPPV 207
           I++      Y+S +    ++  L+ ++   + G+ C L+  PC           D P P 
Sbjct: 462 IKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPC-----------DRPVPP 510

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
           T   S   W+     L+ +E   SG+  ++  G  R S+ + + + ++
Sbjct: 511 TAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKE 558


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score = 72.0 bits (175), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 62/233 (26%), Positives = 109/233 (46%), Gaps = 21/233 (9%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKVA- 90
           K+   AL  F   E   L+LR  E   I+ + +  WW  +  + G E  +PS YV +   
Sbjct: 84  KIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRL-GNEGLIPSNYVTENKI 142

Query: 91  -----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
                + W +  ++R +AE LL      G AF++R+S+   G Y++SV +   ++   I+
Sbjct: 143 TNLEIYEWYHRNITRNQAEHLLRQESKEG-AFIVRDSR-HLGSYTISVFMGARSTEAAIK 200

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HY+I++ D+G  Y++ R  F S+  L+ ++   A G+   LR P  L          +  
Sbjct: 201 HYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLM--------GSCL 252

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
           P T   S   W+     L F++   SG+  ++  G      S+I +A   +++
Sbjct: 253 PATAGFSYGKWEIDPSELAFIKEIGSGQFGVVHLG---EWRSHIQVAIKAINE 302


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score = 72.0 bits (175), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 52/178 (29%), Positives = 84/178 (47%), Gaps = 17/178 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV-QSEVSGREY--HMPSVYVAK---VA 90
           +AL  F A     LS + G+   I    GDWWT  + ++ GR     +P  Y+A+    +
Sbjct: 72  MALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTGFVPYNYLARDSVES 131

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  ++R  A   L+   N  G+FL+R S++    Y LSVR    A     +H++I 
Sbjct: 132 QPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENA-----KHFKIF 186

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           +  +   Y+     F S+  ++EHY      I   L EPC+  ++ P   ++ PPP T
Sbjct: 187 QTGDQ-FYVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCI--RIKP---ENVPPPST 238


>UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE
          Length = 249

 Score = 71.6 bits (174), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 44/143 (30%), Positives = 76/143 (53%), Gaps = 10/143 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ + I+  + DW+  ++E++G E  +P  Y+      W
Sbjct: 1   MEATGKYDFSATAGDELSFRKGDVIKILGTNDDWF--RAEINGMEGFVPRNYIVTTFPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR+ A++ L+    P GAF+IR SQ+  G +S+SVR       + ++H+++ R  
Sbjct: 59  YKENTSRQSAQDELMC--QPIGAFIIRGSQSSPGDFSISVRHE-----NDVQHFKVMRDR 111

Query: 154 NGWLYISPRLTFPSLHALVEHYS 176
            G  Y+   + F SL+ LV++Y+
Sbjct: 112 QGRYYLWSEM-FTSLNKLVDYYT 133


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score = 71.6 bits (174), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 44/142 (30%), Positives = 79/142 (55%), Gaps = 7/142 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R KAEE+L    +  GAFLIRES++  G +SLSV+       + ++H+++ R D
Sbjct: 61  FFGKIPRAKAEEMLSKQRHD-GAFLIRESESAPGDFSLSVKFG-----NDVQHFKVLR-D 113

Query: 154 NGWLYISPRLTFPSLHALVEHY 175
               Y    + F SL+ LV+++
Sbjct: 114 GAGKYFLWVVKFNSLNELVDYH 135


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score = 71.6 bits (174), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 61/204 (29%), Positives = 94/204 (46%), Gaps = 30/204 (14%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKVT----------------AVALGSFPAGEQARLSL 52
           K   P P +  PDQ  V   P+ HK                   VA   FP  E   L L
Sbjct: 157 KEKKPLPPT--PDQNQVMPSPQLHKNCPSALSRPLPPVPEFQQVVAKFDFPGIEAQDLPL 214

Query: 53  RLGEPLTIISEDG-DWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEE 105
             G    I+ +    WW  Q E  GRE  +PS YV  +       + W  + ++R KAE+
Sbjct: 215 VKGCTYVILDDKNPHWWRAQDE-EGREGLIPSTYVYPLTRFDLEQNRWFCKDITRAKAEQ 273

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTF 165
           LL   G+  G+FL+RES ++ G  ++SV    P   + ++HY +++L  G  Y++ + TF
Sbjct: 274 LLRQAGSE-GSFLVRES-SQVGKLTVSVYSCIPC--EVVKHYHVKQLPTGEWYLAEKHTF 329

Query: 166 PSLHALVEHYSELADGICCPLREP 189
            ++  L+ ++   A G+   LR P
Sbjct: 330 STISDLIHYHQHNAAGLVTRLRHP 353


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score = 71.6 bits (174), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 44/142 (30%), Positives = 79/142 (55%), Gaps = 7/142 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R KAEE+L    +  GAFLIRES++  G +SLSV+       + ++H+++ R D
Sbjct: 61  FFGKIPRAKAEEMLSKQRHD-GAFLIRESESAPGDFSLSVKFG-----NDVQHFKVLR-D 113

Query: 154 NGWLYISPRLTFPSLHALVEHY 175
               Y    + F SL+ LV+++
Sbjct: 114 GAGKYFLWVVKFNSLNELVDYH 135


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score = 71.2 bits (173), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 45/144 (31%), Positives = 76/144 (52%), Gaps = 10/144 (6%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           H + A+A   F A  +  LS + G+ L I+S   +W+  ++E+   E ++P  ++     
Sbjct: 14  HNMEAIAKFDFTASGEDELSFQAGDVLKILSSQEEWY--KAELRSHEGYVPKNFIDFHVP 71

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W  E +SR +AE LL+  G   G F++R SQ   G +S+SVR       D ++H+++ R
Sbjct: 72  HWFDEKISRHEAENLLMSKGV--GCFVVRASQNSHGDFSISVRHE-----DDVQHFKVMR 124

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
              G  Y+     F SL+ LV++Y
Sbjct: 125 DSKGSYYLWTE-KFHSLNKLVDYY 147


>UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E29F
          Length = 466

 Score = 70.9 bits (172), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 52/142 (36%), Positives = 69/142 (48%), Gaps = 34/142 (23%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLY 95
           VAL  + A     LS R GE L I+++  GDWW  +S                       
Sbjct: 70  VALYDYDARTDEDLSFRKGELLEILNDTQGDWWLARS----------------------- 106

Query: 96  EGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNG 155
              S   +E+ LLLP N  GAFLIR+S++RR  YSLSVR       D ++HYRI  +   
Sbjct: 107 ---SSSDSEKKLLLPENEHGAFLIRDSESRRNDYSLSVR-----DGDTVKHYRID-IRRR 157

Query: 156 WLYISPRLTFPSLHALVEHYSE 177
           W++ S +  F +L  LVEH  E
Sbjct: 158 WIFCS-KNNFRTLQELVEHTIE 178


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score = 70.9 bits (172), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 48/142 (33%), Positives = 79/142 (55%), Gaps = 7/142 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + +VAL SF A E   L+   G+ L I++ + D    ++E+ G E  +P  Y+    H W
Sbjct: 1   MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
               +SR+ AEE +L+  N  GAFLIRES++  G +S+SV        D+++H+++ R  
Sbjct: 61  YSGRISRQLAEE-ILMKRNHLGAFLIRESESSPGEFSVSVNYG-----DQVQHFKVLREA 114

Query: 154 NGWLYISPRLTFPSLHALVEHY 175
           +G  ++     F SL+ LV+ Y
Sbjct: 115 SGKYFLWEE-KFNSLNELVDFY 135


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score = 70.5 bits (171), Expect = 5e-11,   Method: Compositional matrix adjust.
 Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 11/183 (6%)

Query: 11  SSPSPSSSGPDQEPVSMQP-ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWT 69
           + P      P + P S  P E       AL ++ A     L L+ GE L ++S + ++W 
Sbjct: 172 AEPRAEEEAPPRPPKSAAPPEVVLFEVTALFNYNATNPDDLDLKQGETLEVLSTEEEFWW 231

Query: 70  VQSEVSGREYHMPSVYVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
                +G+   +PS YVAK    +  W    +SR +A+  L +  N  G FL+RES+T  
Sbjct: 232 RARNSAGKVGMIPSNYVAKPGFESEPWYVGKMSRVEAQSKLQI-FNLDGTFLVRESETSA 290

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           G Y+LSV  +      + R+YRIQ  D    YI+ R    ++  L++++     G+C  L
Sbjct: 291 GSYTLSVYFN-----GQPRNYRIQH-DGNEYYITTRHRQKTIKELIDYHKLNGGGLCTRL 344

Query: 187 REP 189
           ++P
Sbjct: 345 KKP 347


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score = 70.5 bits (171), Expect = 5e-11,   Method: Compositional matrix adjust.
 Identities = 48/163 (29%), Positives = 82/163 (50%), Gaps = 11/163 (6%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV--- 89
           KV      + P G+   LS+R  + L  +  DG W   +  ++  E  +P  +VA     
Sbjct: 278 KVVVALYDNDPRGDM-ELSMRKDDYLLELRSDGAWVQCRHLMTNEEGFVPGTFVAPYKSL 336

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            A  W +  ++R KAE+LL +P    G FLIRES++  G +SLS++       + +RH+R
Sbjct: 337 EAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMK-----DGENVRHFR 391

Query: 149 IQRLDNGW-LYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           ++++  G  L  SP      L +L++++     G+   L+ PC
Sbjct: 392 VKKVAGGIKLQGSPSSPHKDLPSLIKYHKRHRGGLTTTLKVPC 434


>UniRef50_P78453 Tyrosine kinase (Fragment) n=11 Tax=Euteleostomi RepID=P78453_HUMAN
          Length = 177

 Score = 70.1 bits (170), Expect = 7e-11,   Method: Compositional matrix adjust.
 Identities = 40/95 (42%), Positives = 55/95 (57%), Gaps = 5/95 (5%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV----AH 91
           +AL  + A  +  L+   GE   I++  +GDWW  +S  SG+   +PS YVA V    A 
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
            W +  + R+ AE  LL PGNP GAFLIRES+T +
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177


>UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE
          Length = 284

 Score = 69.3 bits (168), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 52/166 (31%), Positives = 81/166 (48%), Gaps = 15/166 (9%)

Query: 42  FPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSRE 101
           F    +  LS R G+ L I+    DW+  ++E+ G E ++P  YV +    W  E  SR 
Sbjct: 9   FSGTAEDELSFRKGDTLKILGSQDDWF--KAELHGHEGYVPKNYVDRQIPSWFKESASRG 66

Query: 102 KAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP 161
            AEE L+      GAFLIR SQ+  G +S+SVR      +D ++H+++ +  +G  Y+  
Sbjct: 67  SAEETLM--SREVGAFLIRGSQSSPGDFSISVR----HDYD-VQHFKVMKDKSGHYYLWT 119

Query: 162 RLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
              F SL+ LV+ Y   +       +E  +    G  P    PPP+
Sbjct: 120 E-KFTSLNKLVDFYKTTS---ISKQKEIFLRDGSGDEP--RAPPPI 159


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score = 68.9 bits (167), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 38/112 (33%), Positives = 63/112 (56%), Gaps = 5/112 (4%)

Query: 78  EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           ++ + S+Y   +A+ W +  ++REKAEELL       G FL+RES    G Y+L V    
Sbjct: 18  QFSLVSIYELDLAN-WFFGKITREKAEELL--TPREVGLFLVRESTNFPGDYTLCV--VS 72

Query: 138 PASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           P +  ++ HYR+   ++  + +     FP+L  L++HY   ADG+C  L++P
Sbjct: 73  PQNNKKVEHYRVISTNDNRVTVDEDAFFPNLIELIKHYERDADGLCTMLKKP 124


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score = 68.2 bits (165), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 24/177 (13%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTII--SEDGDWW------TVQSEVSGREYH-----MPS 83
           VAL  F    + +LSLR G+ + I+  +++ +W       T +++ S +        +PS
Sbjct: 121 VALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPS 180

Query: 84  VYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            ++A       + W +  +SR  +E   +L     G+FL+RES+T  G Y++SVR     
Sbjct: 181 NFIAPYNSLDKYTWYHGKISRSDSE--AILGSGITGSFLVRESETSIGQYTISVRHD--- 235

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
              R+ HYRI   +   ++I+  + F +L  LV H+S  ADG+ C L  P   +  G
Sbjct: 236 --GRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKG 290


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score = 68.2 bits (165), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 54/171 (31%), Positives = 82/171 (47%), Gaps = 39/171 (22%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVYV----- 86
             VAL SF A     LS + GE L I+     D DWW  ++  SG    +P  Y+     
Sbjct: 215 VVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARN-ASGTTGLVPRNYIEVVND 273

Query: 87  ---AKVAHG------------------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
              +K +H                   W +  +SRE+AE+LLL      G FL+R+S++ 
Sbjct: 274 SSSSKASHQDFAPQYSGNGEIPMEQQPWYFGRISRERAEDLLL--HGREGEFLVRDSESN 331

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
            G  S+S+R       +R +H+++Q +D G L I  R TF  ++AL+ HY+
Sbjct: 332 PGDLSISMR-----GIERNKHFKVQNVD-GLLKIGNR-TFVDMNALINHYT 375


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score = 67.4 bits (163), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 61/214 (28%), Positives = 91/214 (42%), Gaps = 34/214 (15%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDG--DWW------------TVQSEVSGREYHMP 82
           V L    +  + +LSLR G  L ++  +G  +W               +  V G    +P
Sbjct: 13  VVLYPIESAGRNQLSLRKGCQLRVLRYNGTEEWCEAKVLSTGDPSDNAKCAVVGSVGWVP 72

Query: 83  SVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
           S Y+        H W +  +SR  AE   LL     G+FL+R+S++ RG  S+SVR +  
Sbjct: 73  SNYITPATSLNMHTWYHGAVSRAAAE--YLLSSGINGSFLVRDSESCRGHLSVSVRFNAS 130

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
                + HYRI     G  YISP   F +L  LV H+S  +DG+   L  P         
Sbjct: 131 -----VYHYRINVDTAGLFYISPEHRFQTLPELVHHHSYASDGLAAILHYPA-------- 177

Query: 199 PGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASG 232
             K T P V       +  ++DRS + ++    G
Sbjct: 178 -AKSTKPAVYSMAPDYDEWEIDRSEIHMKQRLGG 210


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score = 67.0 bits (162), Expect = 6e-10,   Method: Compositional matrix adjust.
 Identities = 47/169 (27%), Positives = 78/169 (46%), Gaps = 18/169 (10%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPS 83
           M   +     VAL  + +  +  LS   G+   I+     D  WW  Q+  + ++  +P 
Sbjct: 1   MSATKKNDIFVALDDYASQHKGELSFSKGDNFKILKNAAPDDGWWNAQNLNTKKKGWIPC 60

Query: 84  VYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
             VA         W +  +SR  A+ LL   G   G +L+RESQ++ G Y+L V      
Sbjct: 61  SLVALDGSLELFDWCHGAISRNGADYLLKQHG-IDGMYLVRESQSQPGQYTLDV------ 113

Query: 140 SWDRIR--HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
            W   +  HYRI + D G+ +    + FP++  L++H+   +DG+C  L
Sbjct: 114 -WKEGKSVHYRITKGDEGYFF-RQGVCFPTIPELIQHHQTRSDGLCSSL 160


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score = 67.0 bits (162), Expect = 7e-10,   Method: Compositional matrix adjust.
 Identities = 45/134 (33%), Positives = 70/134 (52%), Gaps = 10/134 (7%)

Query: 42  FPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSRE 101
           F A     LS R G+ L I+S + DW+  ++E++G+E ++P  Y+      W  E  SR 
Sbjct: 9   FMATGDTELSFRKGDILKILSPEDDWF--KAEMNGQEGYVPQNYIEIQTPRWFQENASRS 66

Query: 102 KAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP 161
            AEELL   G   G F+IR  Q+  G +S+SVR         ++H+++ R   G  ++  
Sbjct: 67  AAEELLRHKGV--GEFVIRGCQSSPGEFSISVRHESD-----VQHFKVMRDSRGQYFLWS 119

Query: 162 RLTFPSLHALVEHY 175
              F SL+ LV+ Y
Sbjct: 120 E-KFTSLNKLVDFY 132


>UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59F39_HUMAN
          Length = 376

 Score = 66.6 bits (161), Expect = 8e-10,   Method: Compositional matrix adjust.
 Identities = 51/187 (27%), Positives = 96/187 (51%), Gaps = 17/187 (9%)

Query: 6   SRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SED 64
           ++  +  P P +   ++ P+  +PE  +   +AL  +   +   L+LR  E   ++ S +
Sbjct: 194 TKNASKKPLPPTPEDNRRPL-WEPE--ETVVIALYDYQTNDPQELALRRNEEYCLLDSSE 250

Query: 65  GDWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAFL 118
             WW VQ   +G E ++PS Y+ + +      + W  + +SR+KAE+LLL  G   GAF+
Sbjct: 251 IHWWRVQDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAFM 308

Query: 119 IRESQTRRGCYSLSVRLSRPASWDR--IRHYRIQRLDNG--WLYISPRLTFPSLHALVEH 174
           +R+S+T  G Y++SV      S +   I+HY I+  ++     Y++ +  F S+  L+ +
Sbjct: 309 VRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINY 367

Query: 175 YSELADG 181
           +     G
Sbjct: 368 HQHNGGG 374


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score = 66.2 bits (160), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 46/144 (31%), Positives = 78/144 (54%), Gaps = 12/144 (8%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A+A   F A     LS R  + L I++  +D +W+  ++E+ G+E  +PS Y+    H
Sbjct: 1   MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWY--RAELDGKEGLIPSNYIEMKNH 58

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W Y  ++R  AE+  LL     GAFLIR S++  G +SLSV+       D ++H+++ R
Sbjct: 59  DWYYGRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSVKCP-----DGVQHFKVLR 111

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
                 ++   + F SL+ LVE++
Sbjct: 112 DAQSKFFLWV-VKFNSLNELVEYH 134


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score = 66.2 bits (160), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 46/143 (32%), Positives = 79/143 (55%), Gaps = 12/143 (8%)

Query: 50  LSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV---AHGWLYEGLSREKAEE 105
           LS+  G+ L +I + + +WW  + +  GR  ++PS YV +    +  W +  +SR +A  
Sbjct: 256 LSITEGDKLWVIDQSEPNWWKAR-DSQGRVGYIPSNYVRQAGIESEAWFHGRISRAEAAA 314

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTF 165
           LL +    G  FL+RES+++ G YSLSV     +  D +RHY I++ +    YI+ R  F
Sbjct: 315 LLHVAKQEG-CFLVRESESKVGEYSLSV-----SHGDSLRHYHIKK-EGEEFYINDRHRF 367

Query: 166 PSLHALVEHYSELADGICCPLRE 188
           P +  L+E++   + G+   LR+
Sbjct: 368 PDICKLIEYHKLNSGGLVTRLRK 390


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score = 66.2 bits (160), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 50/170 (29%), Positives = 79/170 (46%), Gaps = 18/170 (10%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 11  HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 63

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
              +G LY+S    F +L  LV H+S +ADG+   L  P         P ++ P    V 
Sbjct: 64  TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA--------PKRNKPTIYGVS 115

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGL--RESLSSYI-SLAEDPLD 257
            +   W+     +        G+   + EG+  + SL+  + +L ED ++
Sbjct: 116 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME 165


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score = 66.2 bits (160), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 45/134 (33%), Positives = 70/134 (52%), Gaps = 10/134 (7%)

Query: 42  FPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSRE 101
           F A     LS R G+ L I+S + DW+  ++E++G+E ++P  Y+      W  E  SR 
Sbjct: 9   FMATGDTELSFRKGDILKILSPEDDWF--KAEMNGQEGYVPQNYIEIQTPRWFQENASRS 66

Query: 102 KAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP 161
            AEELL   G   G F+IR  Q+  G +S+SVR         ++H+++ R   G  ++  
Sbjct: 67  AAEELLRHKGV--GEFVIRGCQSSPGEFSISVRHESD-----VQHFKVMRDSRGQYFLWS 119

Query: 162 RLTFPSLHALVEHY 175
              F SL+ LV+ Y
Sbjct: 120 E-KFTSLNKLVDFY 132


>UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo salar
           RepID=B5X487_SALSA
          Length = 289

 Score = 65.9 bits (159), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 10/134 (7%)

Query: 42  FPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSRE 101
           F A  +  LS R G+ L I+    +W+  ++E+ G+E  +P  Y+ +    W  E  SR 
Sbjct: 9   FNATAEDELSFRKGDILKILGSQDEWF--KAELHGQEGFVPQNYIERQTPSWFKETASRS 66

Query: 102 KAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP 161
            AEELL+      G FLIR SQ+  G +S+SVR      +D ++H+++ +   G  ++  
Sbjct: 67  SAEELLM--SREVGGFLIRGSQSSPGEFSISVR----HEFD-VQHFKVMKDSKGHYFLWS 119

Query: 162 RLTFPSLHALVEHY 175
              F SL+ LV+ Y
Sbjct: 120 E-KFTSLNKLVDFY 132


>UniRef50_UPI00015B5EF2 PREDICTED: similar to ENSANGP00000021630 n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B5EF2
          Length = 389

 Score = 65.9 bits (159), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 35/94 (37%), Positives = 52/94 (55%), Gaps = 2/94 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE   E+L     P GAF++RES ++ GCY+LS+R+ R      I HY I R 
Sbjct: 256 WFQAGIPREITLEVL--SQEPEGAFMVRESTSKPGCYALSLRVPREFQPSGIAHYLIMRT 313

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           + G+        F +L AL+ H+S + + + CPL
Sbjct: 314 NKGYKIKGFTKEFTTLTALITHHSVMPELLPCPL 347


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score = 65.5 bits (158), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 53/174 (30%), Positives = 82/174 (47%), Gaps = 13/174 (7%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWW--TVQSEVSGR--EYHMPSVYVAKV--- 89
           V L  F +     LS R G+   +  ++  WW  T+  E  G   + ++P  Y+A+    
Sbjct: 14  VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            +  W +  +SR +A   L   GN  GAFLIR S+     Y LSVR ++      +RHY+
Sbjct: 74  ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHYK 128

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           I R   G L+++  ++F SL  LV ++   +      L  PC   +  PLP  D
Sbjct: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWD 182


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score = 64.7 bits (156), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 7/96 (7%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           + W +  +SR+  E LL       G+FL+R S++  G  S++VR        R+ HYRI 
Sbjct: 239 YSWYHGAVSRQAGEHLLR--SGITGSFLVRASESAPGQLSVTVR-----HLGRVYHYRIS 291

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           +   G  YI+    FP++  L+EH+S  ADG+ CPL
Sbjct: 292 QDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPL 327


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score = 64.3 bits (155), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 7/96 (7%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           + W +  +SR+  E LL       G+FL+R S++  G  S++VR        R+ HYRI 
Sbjct: 76  YSWYHGAVSRQAGEHLLR--SGITGSFLVRASESAPGQLSVTVR-----HLGRVYHYRIS 128

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           +   G  YI+    FP++  L+EH+S  ADG+ CPL
Sbjct: 129 QDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPL 164


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 63.9 bits (154), Expect = 5e-09,   Method: Compositional matrix adjust.
 Identities = 36/101 (35%), Positives = 51/101 (50%), Gaps = 7/101 (6%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE  E+LL   G P G FL+RES    G ++L +     A   ++ HYRI++ 
Sbjct: 148 WFHSMISRENTEKLL--RGKPDGTFLVRESTNFPGDFTLCM-----AYHGKVEHYRIEQT 200

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
             G L       F +L  LV HY   ADG+C  L  P + +
Sbjct: 201 SGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICE 241


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score = 63.5 bits (153), Expect = 6e-09,   Method: Compositional matrix adjust.
 Identities = 51/212 (24%), Positives = 95/212 (44%), Gaps = 33/212 (15%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEVSGREYHMPSVYVAKVAHGWL 94
            +AL  +       L L  G    +I++   DWWTV++                 ++GW 
Sbjct: 172 VIALQEYVPSRDTDLPLEKGHEYILINKSNIDWWTVRN-----------------SNGWY 214

Query: 95  YEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD----RIRHYRIQ 150
            + ++R +A+ELL+  G   GAF++R+S +  G Y++SV    P+       +++HY+I+
Sbjct: 215 SKNMNRMQAQELLMREGKE-GAFMVRDS-SHMGVYTVSVFTKAPSQSGEKNPKVKHYQIR 272

Query: 151 RLDNGW--LYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           + + G    Y++    F ++  L+ ++   A G+   LR P         P   +   V+
Sbjct: 273 QTETGAGPFYLAENYLFNTIPELIHYHQHNAAGLITRLRHPVS-------PDGSSAQQVS 325

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
            P  +  W+     L   +   SG+  L+ EG
Sbjct: 326 APFEADQWELNPDELTLGQEIGSGQFGLVLEG 357


>UniRef50_UPI000186F028 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186F028
          Length = 378

 Score = 63.5 bits (153), Expect = 6e-09,   Method: Compositional matrix adjust.
 Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 2/94 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE    L +L   P GAF++RES ++ GCY+LS+R+ R      I HY I R 
Sbjct: 245 WFQAGIPREIT--LEVLGQEPVGAFMVRESTSKPGCYALSLRVPRDFQPSGIAHYLIMRT 302

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
             G+        F +L AL+ H+S + + + CPL
Sbjct: 303 MKGYKIKGFTKEFTTLTALITHHSVMPELLPCPL 336


>UniRef50_UPI0000D555ED PREDICTED: similar to CG33993 CG33993-PA n=2 Tax=Endopterygota
           RepID=UPI0000D555ED
          Length = 562

 Score = 63.2 bits (152), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 34/94 (36%), Positives = 53/94 (56%), Gaps = 2/94 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE A  L +L   P GAF++RES ++ GC++LS+R+ R      I HY I R 
Sbjct: 429 WFQAGIPREIA--LEILAQEPVGAFMVRESTSKPGCFALSLRVPRSFQPTGIAHYLIVRT 486

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           + G+        F +L +L+ H+S + + + CPL
Sbjct: 487 NKGYKIKGFTKEFTTLTSLITHHSVMPELLPCPL 520


>UniRef50_B1AH86 GRB2-related adaptor protein 2 (Fragment) n=3 Tax=Tetrapoda
           RepID=B1AH86_HUMAN
          Length = 97

 Score = 62.8 bits (151), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 37/101 (36%), Positives = 58/101 (57%), Gaps = 4/101 (3%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVA   F A  +  LS   G+ L I+S   +W+  ++E+  +E ++P  ++      W
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWF--KAELGSQEGYVPKNFIDIQFPKW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
            +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR
Sbjct: 59  FHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR 97


>UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C9CC
          Length = 388

 Score = 62.4 bits (150), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 51/152 (33%), Positives = 77/152 (50%), Gaps = 14/152 (9%)

Query: 93  WLYEGL-SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +E + +R +A+  LL P N  GAFL+ +       Y LS ++ +  +    RHYRI++
Sbjct: 1   WYFENVKTRVEAKRCLLRPENKEGAFLVWKCDENNH-YYLSGKVHKVKNGPHARHYRIKQ 59

Query: 152 LDNGW-LYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
            +N    ++    TF SL  L+E YS+   G+C  L E CV  KL      D P P T+ 
Sbjct: 60  GENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEACV--KL------DQPVPQTLS 111

Query: 211 TSSLNWKKLDRSLLFLEAP-ASGEASLLSEGL 241
             S    ++DRS L  +    SGE + + +GL
Sbjct: 112 FDSKC--EIDRSSLTKQQKLGSGEFADVWQGL 141


>UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostomi RepID=KSYK_HUMAN
          Length = 635

 Score = 62.0 bits (149), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 41/114 (35%), Positives = 60/114 (52%), Gaps = 11/114 (9%)

Query: 86  VAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           +A  AH    W +  +SRE++E+++L+     G FLIR ++   G Y+L +         
Sbjct: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHE-----G 211

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
           ++ HYRI +   G L I     F +L  LVEHYS  ADG+   L  PC  QK+G
Sbjct: 212 KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC--QKIG 263



 Score = 55.1 bits (131), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 32/97 (32%), Positives = 54/97 (55%), Gaps = 5/97 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           + +  ++RE+AE+ L+  G   G +L+R+S+   G ++LSV   R A      HY I+R 
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKA-----HHYTIERE 69

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            NG   I+   T  S   L  ++S+ +DG+ C L++P
Sbjct: 70  LNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score = 60.8 bits (146), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 46/127 (36%), Positives = 67/127 (52%), Gaps = 14/127 (11%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV----A 90
           VAL  F AG + +LSL+ GE + I+S  + G+W    S+ SG    +PS YV  +     
Sbjct: 193 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEK 251

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  +SR  AE   LL     G+FL+RES++  G  S+S+R        R+ HYRI 
Sbjct: 252 HSWYHGPISRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIS 304

Query: 151 RLDNGWL 157
              +G +
Sbjct: 305 EDPDGKV 311


>UniRef50_Q7Q480 AGAP008273-PA (Fragment) n=3 Tax=Culicidae RepID=Q7Q480_ANOGA
          Length = 291

 Score = 60.1 bits (144), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 35/97 (36%), Positives = 53/97 (54%), Gaps = 3/97 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   GL RE + E+L       GAFL+R S T+ GC++LS+R+  P S  ++ HY I + 
Sbjct: 163 WFQAGLPRELSLEVLT--QQSPGAFLVRRSTTKHGCFALSLRVP-PGSGPKVVHYLIMKT 219

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           + G+        F SL AL+ H+S + + +  PL  P
Sbjct: 220 ERGYKIKGFTKEFSSLRALITHHSVMPEMLPVPLSLP 256


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score = 60.1 bits (144), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 45/152 (29%), Positives = 74/152 (48%), Gaps = 20/152 (13%)

Query: 93  WLYEGLSREKAEELLLLPGNPG--GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           W +  + R  AE LL    N G  G+FLIRES++  G  ++S+R        +I HYRI 
Sbjct: 167 WYHGAIQRSYAEYLL----NSGITGSFLIRESESHPGQLTISLRYE-----GQIWHYRIH 217

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
           R D+   Y+     F S+  LV H+ + +DG+ C L        L P P +D        
Sbjct: 218 RDDSNMYYVIESNKFTSVSDLVHHHEKHSDGLACTL--------LYPAPKRDRTSSELRM 269

Query: 211 TSSLNWKKLDRSLLFLEAP-ASGEASLLSEGL 241
             S + +++DR+ + ++    SG+  ++ E +
Sbjct: 270 DPSFDIREIDRTEIVMKHKLGSGQYGVVYEAV 301


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score = 60.1 bits (144), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 37/108 (34%), Positives = 57/108 (52%), Gaps = 9/108 (8%)

Query: 86  VAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           + K+ H    W +  LSRE+AE+ ++  G   G FL+RE +T  G ++LS+  +     +
Sbjct: 201 LKKIMHQDKPWFHHKLSREEAEQRIVSAGLQEGKFLVRE-RTEEGSFALSLCYN-----N 254

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            + HY+I +   G L I     F SL  +V+HY    DG+ C L  PC
Sbjct: 255 FVYHYKIDKDCTGQLSIKEGPKFDSLIQMVDHYQLKKDGLLCCLLVPC 302



 Score = 56.6 bits (135), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 37/102 (36%), Positives = 51/102 (50%), Gaps = 6/102 (5%)

Query: 94  LYEG-LSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
            Y G ++RE+AE  L   G   G FL+RES  R G Y+LS+        D + HY I+R 
Sbjct: 56  FYHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSL-----CYEDDVYHYAIERQ 110

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
            +G + I     F     LV ++    DG+ C L  PC LQ+
Sbjct: 111 YDGTVAIKDGKNFAGPIELVSNHMNREDGLLCRLLRPCNLQQ 152


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score = 60.1 bits (144), Expect = 8e-08,   Method: Compositional matrix adjust.
 Identities = 39/120 (32%), Positives = 59/120 (49%), Gaps = 11/120 (9%)

Query: 75  SGREYHMPSVYVAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
           +G++  +   YVA        W +  ++RE  E++L   G   G FL+R+S    G Y+L
Sbjct: 25  NGKQTSVDRRYVANNEQHPKLWYHGNITREHTEKIL--SGQADGTFLVRDSTNFPGDYTL 82

Query: 132 SVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
            +     A   ++ HYRI +L NG L      TF +L  L+ HY   ADG+C  L  P +
Sbjct: 83  CM-----AFNGKVEHYRIYQL-NGILTCDHEETFDNLTQLIAHYKRDADGLCHRLITPVI 136


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score = 59.7 bits (143), Expect = 9e-08,   Method: Compositional matrix adjust.
 Identities = 52/212 (24%), Positives = 96/212 (45%), Gaps = 18/212 (8%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEVSGREYHMPSVYVAKV----- 89
            VAL  +       L LR G+   I+ E    WW  + + +G+E ++PS YV +      
Sbjct: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIE 277

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS-WDRIRHYR 148
            + W  + ++R +AE+LL   G  GG F++R+S ++ G Y++SV           IRHY 
Sbjct: 278 MYEWYSKHMTRSQAEQLLKQEGKEGG-FIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYV 335

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           +        Y++ +  F ++  L+ ++   + G+   L+ P   Q        +   P T
Sbjct: 336 VCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQ--------NKNAPST 387

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
                 +W+   + L FL+   +G+  ++  G
Sbjct: 388 AGLGYGSWEIDPKDLTFLKELGTGQFGVVKYG 419


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score = 59.7 bits (143), Expect = 9e-08,   Method: Compositional matrix adjust.
 Identities = 34/99 (34%), Positives = 52/99 (52%), Gaps = 7/99 (7%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE+AEE+L   G   G F++RES +  G + LSV        D + HY+I+R 
Sbjct: 9   WFHGKISRERAEEILRQEGG-DGVFMVRESASSEGDFVLSVLFQ-----DEMVHYQIRRH 62

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            D+ +  I        L +L+EHY E  +G+   L+  C
Sbjct: 63  GDDAFFSIDDHTPIHGLESLIEHYRESPNGLVTKLQAIC 101


>UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYF4_SCHMA
          Length = 855

 Score = 59.3 bits (142), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 37/130 (28%), Positives = 76/130 (58%), Gaps = 9/130 (6%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV---- 89
           T +A+ ++    + +L L+ GE   ++++ +  WW V++ ++G+  ++P+ YV K     
Sbjct: 315 TVIAVYNYNPVRENQLPLQKGEKYYVVNQSNAQWWYVKN-MTGQLGYVPTNYVHKPNSLN 373

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR--HY 147
           +  W Y+ ++R++AE +LL   N  G FL+R+S +++  Y+LSV    P +  +++  HY
Sbjct: 374 SFDWYYKDITRQQAEAILL-DENREGCFLVRDSVSKKNTYTLSVTSKDPEAPGKLKVHHY 432

Query: 148 RIQRLDNGWL 157
            I R ++  L
Sbjct: 433 HIHRTESSSL 442


>UniRef50_Q4T2Z8 Chromosome 18 SCAF10147, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4T2Z8_TETNG
          Length = 279

 Score = 58.9 bits (141), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 54/190 (28%), Positives = 91/190 (47%), Gaps = 43/190 (22%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTI--ISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + AVAL SFPA E   L+ + G+ + +  + +D  W+T  +E+ G+  ++P  Y++ + +
Sbjct: 1   MEAVALFSFPAAEADELTFQEGDVIKVTEMEDDSGWFT--AEIQGKRGYIPQNYISLLPY 58

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW---------- 141
            W    +SR +AE+ L       G FL+RES++  G +S+SV  S   +W          
Sbjct: 59  PWFVGRVSRLEAEKRLRW--QDPGVFLVRESESAPGEFSVSV--SFVFNWHKTNLSLSSG 114

Query: 142 -------------------DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY---SELA 179
                              +R+ H+R+  L+ G  Y     +F SL+ LV+ Y   S   
Sbjct: 115 GHSSDLRAWVLPHDIVSYGNRVEHFRV--LEGGGQYCIWEESFCSLNRLVDFYRTHSIAM 172

Query: 180 DGICCPLREP 189
           D + C LR+P
Sbjct: 173 DKVVC-LRDP 181


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score = 58.9 bits (141), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 47/166 (28%), Positives = 75/166 (45%), Gaps = 19/166 (11%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSE-----VSGREYHMPSVYVAKVAH 91
           +AL  + A     L+ + G+ + I+ +  +W   Q        S  E  +P+ YV K + 
Sbjct: 65  IALYDYVARTNKDLTFKKGDTMVILKKGQNWSIAQLLEPNPLYSVTEGSIPTNYVKKQSS 124

Query: 92  -----GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                 W+++   R +A  LL+ P N  G FL R   T    Y+LSVR     +   + H
Sbjct: 125 VVSQPSWMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNPNEYALSVR-----NGATVNH 179

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSE--LADGICCPLREPC 190
            +I+++      I     F +L+ LV +Y E  LA+ I   LR PC
Sbjct: 180 IKIEKMGGQGYSIDHHTMFATLNDLVGYYQENMLANDI--RLRSPC 223


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score = 58.9 bits (141), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 35/83 (42%), Positives = 50/83 (60%), Gaps = 8/83 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR       D ++H+++ R 
Sbjct: 32  WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHE-----DDVQHFKVMR- 83

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
           DN   Y      FPSL+ LV++Y
Sbjct: 84  DNKGNYFLWTEKFPSLNKLVDYY 106


>UniRef50_A7URX1 AGAP006893-PA n=3 Tax=Culicidae RepID=A7URX1_ANOGA
          Length = 374

 Score = 58.5 bits (140), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 37/97 (38%), Positives = 55/97 (56%), Gaps = 4/97 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE + E+L    NPG AFL+R+S T+ GC++LS+R+  PA   ++ HY I R 
Sbjct: 255 WFQAGIPREISLEVLSR-QNPG-AFLVRQSTTKPGCFALSLRVPPPA--PKVAHYLILRT 310

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
             G+        F SL AL+ H+S + + +  PL  P
Sbjct: 311 IRGYKIKGFTKEFTSLRALITHHSVMPELLPVPLALP 347


>UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=35 Tax=Euteleostomi
           RepID=Q64725-2
          Length = 606

 Score = 58.2 bits (139), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 44/131 (33%), Positives = 63/131 (48%), Gaps = 14/131 (10%)

Query: 86  VAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           +A  AH    W +  +SR+++E+ +L+     G FLIR ++   G ++L +         
Sbjct: 157 IATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIR-ARDNNGSFALCLLHE-----G 210

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL---P 199
           ++ HYRI R   G L I     F +L  LVEHYS   DG+   L  PC  QK+G     P
Sbjct: 211 KVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPC--QKIGVQMGHP 268

Query: 200 GKDTPPPVTVP 210
           G     PV  P
Sbjct: 269 GSSNAHPVPPP 279



 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 10/111 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           + +  ++RE+AE+ L+  G   G +L+R+S+   G ++LSV  +R A      HY I+R 
Sbjct: 14  YFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA-----HHYTIERE 68

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC-----VLQKLGPL 198
            NG   IS      S   L  ++S+  +G+ C L++P      V  K GP 
Sbjct: 69  LNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKTGPF 119


>UniRef50_B7QKA0 Putative uncharacterized protein n=1 Tax=Ixodes scapularis
           RepID=B7QKA0_IXOSC
          Length = 346

 Score = 58.2 bits (139), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 2/94 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE A E+L     P G+F++R+S ++ GC++LS+R+ R      I HY I   
Sbjct: 214 WFQAGIPREIALEVLGQ--EPVGSFMVRKSTSKPGCFALSLRVPRSLQPTGISHYLIMHT 271

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           + G+        F +L +L+ H+S + + + CPL
Sbjct: 272 NRGYKIKGFTKEFGTLTSLITHHSVMPELLPCPL 305


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score = 57.8 bits (138), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 56/207 (27%), Positives = 91/207 (43%), Gaps = 21/207 (10%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKVA---- 90
            VA+  F A E   L L  G+   I+ + D  WW  + +  G E ++PS YV        
Sbjct: 184 VVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKY-GNEGYIPSNYVTGKKSNNL 242

Query: 91  --HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR-IRHY 147
             + W    ++R KAE+LL      GG F++R+S ++ G Y++S+            RHY
Sbjct: 243 DQYEWYCRNMNRSKAEQLLRSEDKEGG-FMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHY 300

Query: 148 RIQRLDNG--WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
            I+         Y++ +  F S+  ++E++   A G+   LR P  ++      GK+   
Sbjct: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVK------GKNA-- 352

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASG 232
           P T   S   W+     L F+    SG
Sbjct: 353 PTTAGFSYEKWEINPSELTFMRELGSG 379


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score = 57.0 bits (136), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 37/117 (31%), Positives = 63/117 (53%), Gaps = 14/117 (11%)

Query: 77  REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
           R+Y  P   ++K  + W +  L R++A ELL   GN  G++L+R S    G Y L++ ++
Sbjct: 270 RKYKAPKPVLSK--YNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVN 327

Query: 137 RPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
                DR  H++I+  +NG+ +I       SL  ++++YS + DG+      P VLQ
Sbjct: 328 -----DRSFHFQIKN-ENGYYFIDDGPLLESLEHVIDYYSRMQDGL------PTVLQ 372


>UniRef50_C4Q5Y9 Tensin-related n=1 Tax=Schistosoma mansoni RepID=C4Q5Y9_SCHMA
          Length = 1117

 Score = 57.0 bits (136), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 37/97 (38%), Positives = 50/97 (51%), Gaps = 2/97 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W    L RE A ELL       G+FL+R S T  GC +LSVR+    +   I HY IQ+ 
Sbjct: 791 WFQAMLPREIAFELL--AKEEVGSFLVRNSATHPGCCALSVRVPNKDNPIGITHYLIQKT 848

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           + G         +PSL ALV H + + + + CPL+ P
Sbjct: 849 NRGVRLKGLDKEWPSLQALVTHLTVIPEMLPCPLKLP 885


>UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3XYL7_BRAFL
          Length = 296

 Score = 57.0 bits (136), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 34/96 (35%), Positives = 50/96 (52%), Gaps = 7/96 (7%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W    + RE A  +  L     GAF++RES +  GCY+LS+R     +   I +Y I +
Sbjct: 197 AWYKGNVPREMA--MAELERQCAGAFMVRESGSNPGCYALSLR-----TMAGISNYLIGK 249

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            D G+  +    +FP LH L+ HYS  A+ + C LR
Sbjct: 250 TDKGYTIMGFGKSFPDLHTLIIHYSVYAEMLPCRLR 285


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score = 56.6 bits (135), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 48/163 (29%), Positives = 85/163 (52%), Gaps = 17/163 (10%)

Query: 37  VALGSFP--AGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA-KVAHGW 93
           VAL  F     EQ  L+ + GE L +I  +   W +  +   ++  +P  Y+  + +H W
Sbjct: 4   VALFDFSPSKEEQDELAFKKGEVLKVIKREDRHWLLAHQ-GAKQGLVPENYLKIEKSHPW 62

Query: 94  LYEGLSREKAEELLL-LPGNPGGAFLIRESQTR--RGCYSLSVRLSRPASWDRIRHYRIQ 150
               +SR+ AEE L+ +P +  GAF+IR+S++    G +SLSV+       D+++H++I 
Sbjct: 63  YVGKISRKVAEEYLMSMPSD--GAFMIRDSESNPDSGNFSLSVKFR-----DQVQHFKI- 114

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSE--LADGICCPLREPCV 191
             D    Y    + F S++ LV+++ +  ++      L EPCV
Sbjct: 115 LTDLAGKYFLWVVKFTSINDLVDYHKDNSVSRTQEIVLNEPCV 157


>UniRef50_Q56A36 Hematopoietic SH2 domain-containing protein homolog n=3 Tax=Danio
           rerio RepID=HSH2D_DANRE
          Length = 365

 Score = 56.6 bits (135), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 36/96 (37%), Positives = 52/96 (54%), Gaps = 9/96 (9%)

Query: 78  EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           EY    +    V   W +  +SR+ AEE+L+    P G FLIR S++R G Y+LS R   
Sbjct: 19  EYQRSCILENGVVPEWFHGIISRKAAEEMLMC--KPAGYFLIRVSESRVG-YTLSYR--- 72

Query: 138 PASWDRIRHYRIQRL-DNGWLYISPRLTFPSLHALV 172
             + DR RH+ I  L DN ++ +  +  + SLH LV
Sbjct: 73  --AEDRCRHFMINVLPDNQFMIVGEKTVYCSLHDLV 106


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 56.2 bits (134), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 32/88 (36%), Positives = 54/88 (61%), Gaps = 8/88 (9%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
           ++A  W +  ++R+ AE LL+   N  GAFL+R S++  G YSLSV+ +     + ++H+
Sbjct: 9   EIAMAWFFPTITRKNAELLLMQERN--GAFLVRRSESSEGLYSLSVKYN-----ESVQHF 61

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHY 175
           RI +   G  ++   + FPSL ALV++Y
Sbjct: 62  RILQDTAGKFHLWI-VKFPSLDALVDYY 88


>UniRef50_Q6NR09 CG33993 n=13 Tax=Diptera RepID=Q6NR09_DROME
          Length = 421

 Score = 55.8 bits (133), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 35/98 (35%), Positives = 52/98 (53%), Gaps = 4/98 (4%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE + E L       GAFL+R+S T+ GC++LS+R+  P+   R+ HY I R
Sbjct: 285 AWFQAGIPREISLEAL--SRQSPGAFLVRQSSTKPGCFALSLRVPPPS--PRVAHYLILR 340

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
              G+        F SL AL+ H+S + + +  PL  P
Sbjct: 341 TQRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLP 378


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score = 55.8 bits (133), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 10/104 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R++AE LL       G FL+RES    G Y+L V         ++ HYR++ L
Sbjct: 684 WFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQ-----SKVEHYRVKYL 736

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
           +N  L I     F +L  LV HY   ADG+C  L +   L KLG
Sbjct: 737 ENK-LTIDDEEYFENLGQLVAHYEADADGLCTQLIK--CLPKLG 777


>UniRef50_UPI000180B667 PREDICTED: similar to GF12762 n=1 Tax=Ciona intestinalis
           RepID=UPI000180B667
          Length = 886

 Score = 55.8 bits (133), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 32/99 (32%), Positives = 51/99 (51%), Gaps = 5/99 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL++ + R KA E+L + G   G+F++R S+   G + L++     A    + +Y I+  
Sbjct: 478 WLHDAMDRFKAVEMLEMSGLVDGSFMVRLSKRNPGQHVLTM-----AHDKTVYNYEIRNR 532

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
            N W YI     F SL  LV++Y   +DG+   L  PC 
Sbjct: 533 GNQWYYIDDGPLFTSLEYLVDYYCRRSDGLPAELTSPCT 571



 Score = 52.8 bits (125), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 5/97 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL++ + R KA E+L + G   G+F++R S+   G + L++     A    + +Y I+  
Sbjct: 321 WLHDAMDRFKAVEMLEMSGLVDGSFMVRLSKRNPGQHVLTM-----AHDKTVYNYEIRNR 375

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            N W YI     F SL  LV++Y   +DG+   L  P
Sbjct: 376 GNQWYYIDDGPLFTSLEYLVDYYCRCSDGLPAELTSP 412



 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 46/157 (29%), Positives = 70/157 (44%), Gaps = 19/157 (12%)

Query: 43  PAGEQARLS-LRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSRE 101
           P GE+     L+LGEPL  I++   + +  S +S +          K    W +E L+R 
Sbjct: 4   PLGERTICQRLKLGEPLADITQH--YQSYSSTISSK----------KPEDLWFHEKLTRG 51

Query: 102 KAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR-LDNGWLYIS 160
            AE  L   GN  G FL+RES    G + LS+  +  A     +H++I   + +G   I 
Sbjct: 52  NAEFNLKKYGNEQGMFLVRESINVPGSFVLSLTHNGKA-----QHFQINTSIHSGCFSID 106

Query: 161 PRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGP 197
               F  L  L+  Y   ++G+   L   CV  +L P
Sbjct: 107 NGPPFVGLDQLIAFYRAASNGLPTILTRSCVGYELRP 143


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score = 55.8 bits (133), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 38/104 (36%), Positives = 53/104 (50%), Gaps = 10/104 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R++AE LL       G FL+RES    G Y+L V         ++ HYR++ L
Sbjct: 479 WFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQ-----SKVEHYRVKYL 531

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
           +N  L I     F +L  LV HY   ADG+C  L +   L KLG
Sbjct: 532 ENK-LTIDDEEYFENLGQLVAHYEADADGLCTQLIK--CLPKLG 572


>UniRef50_Q9VRS2 CG32406 n=13 Tax=Drosophila RepID=Q9VRS2_DROME
          Length = 474

 Score = 55.8 bits (133), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 3/97 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+SR+ A E+L       GAFL+R+S ++ GCY+L++R+  P    +I +Y I R 
Sbjct: 342 WYQAGISRDIAVEVL--QSKSPGAFLVRKSSSKPGCYALTLRVPSPP-GPKIANYIILRS 398

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
             G+     R  F SL AL+ H+S + + +  PL  P
Sbjct: 399 PRGYKIKGFRKEFSSLKALITHHSVMPELLPVPLAMP 435


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score = 55.5 bits (132), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 38/105 (36%), Positives = 53/105 (50%), Gaps = 14/105 (13%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  + RE+AE LL       G FL+RES    G Y+L V  +     +++ HYRI+  
Sbjct: 378 WFHGRIKREEAENLL--KPREDGLFLVRESTNFPGDYTLCVCFN-----EKVEHYRIKYA 430

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICC------PLREPCV 191
           +N  L I     F +L  LVEHY+  +DG+C       P  E CV
Sbjct: 431 ENK-LTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEEFCV 474


>UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicum
           RepID=Q5DBN4_SCHJA
          Length = 312

 Score = 55.5 bits (132), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 18/172 (10%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A+A  +F   E   L    G  L I+   ED +W+  +     +E  +P+ Y++   H
Sbjct: 1   MEAIANYAFSPTEPDELGFEKGSTLCIVGMEEDPNWYKARQ--GNQEGMVPANYISLCPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AE  LL           P GAF++R+S+   G +S+SV+         +
Sbjct: 59  PWYIPKCSRREAEARLLETDPNTHRDVQPDGAFVLRQSENDPGHFSISVK-----EGSSV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVE-HYSELADGICCPLREPCVLQKL 195
            H+RI    +G  YI     F S++AL++ H  +   GI   L   CV  K+
Sbjct: 114 LHFRIFFDPSGKYYIWTN-KFSSINALIDYHRHQTIYGIKALLLRDCVSSKI 164


>UniRef50_C3ZG97 Putative uncharacterized protein n=3 Tax=Chordata RepID=C3ZG97_BRAFL
          Length = 1558

 Score = 55.1 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 93   WLYEGLSREKAEELLLLPGNPGGAFLIRE----SQTRRGCYSLSVRLSRPASWDRIRHYR 148
            W    L R   +  LL   NP G FL+R      +T    Y++SV  S+  + DR+ H+ 
Sbjct: 1261 WFVGPLDRRDTDNRLLCDDNPVGTFLVRSREDIGETGSHLYTISVLRSKTGN-DRVSHFN 1319

Query: 149  IQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
            +QR   G L+++  + F SL  LVEHY  L
Sbjct: 1320 VQRSTEGKLFVAADMEFDSLTELVEHYLSL 1349


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score = 55.1 bits (131), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 54/205 (26%), Positives = 86/205 (41%), Gaps = 56/205 (27%)

Query: 14  SPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS---EDGDWWTV 70
           S SS G D    +  P+   +    L +F       L+    E L IIS   +D DWW  
Sbjct: 174 STSSKGDD----NSIPDDFVLGVTTLYAFKGRTDEELNFDASELLDIISNPSDDQDWWKA 229

Query: 71  QSEVSGREYHMPSVYVAKVAHG-------------------------------------- 92
           ++++ G    +PS YV  V +                                       
Sbjct: 230 RNKL-GTVGLVPSNYVKVVENADPVCPTKFFIEDAVPPKPIEMHDEDNSFTPSSSVGFYD 288

Query: 93  --WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  ++R+ +E++L  PG   G FLIRES+T  G +++SV+       +R++H+++ 
Sbjct: 289 RDWFHGRITRQDSEKILGCPGE-SGLFLIRESETMPGDFAVSVKAP-----ERVKHFKVT 342

Query: 151 RLDNGWLYISPRLTFPSLHALVEHY 175
           R D  +  I  R  F SL  LV+HY
Sbjct: 343 RSDKKFC-IGQR-KFESLDDLVDHY 365


>UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE
          Length = 321

 Score = 54.7 bits (130), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 34/85 (40%), Positives = 48/85 (56%), Gaps = 8/85 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W    L+R  AEELLL  G P GAFLIR S ++  CY+ SV ++      ++RH  I+  
Sbjct: 219 WFVGDLARGPAEELLL--GKPNGAFLIRNSSSK-DCYACSVVVN-----SQVRHCVIRHT 270

Query: 153 DNGWLYISPRLTFPSLHALVEHYSE 177
           + G+ ++ P     SL  LV HYS+
Sbjct: 271 ERGYGFVEPFDLHKSLKDLVLHYSQ 295



 Score = 41.6 bits (96), Expect = 0.025,   Method: Compositional matrix adjust.
 Identities = 29/84 (34%), Positives = 43/84 (51%), Gaps = 9/84 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTR-RGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SRE+  E+L   G P GAFL+R++  + +G Y+L+VR +      RI H     
Sbjct: 32  WYWADISREEVNEIL--HGMPDGAFLVRDASCKVQGEYTLTVRNNGTNKLIRILH----- 84

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
              G    S  LTF S+  L+  Y
Sbjct: 85  -QEGKFGFSEPLTFSSVPELISFY 107


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score = 54.3 bits (129), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 49/171 (28%), Positives = 77/171 (45%), Gaps = 18/171 (10%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + AVA   F   E   L    G  L I+   ED +W+  ++ +  +E  +P+ Y++   H
Sbjct: 1   MEAVANYPFTPTEPDELGFEKGSTLYIVGMEEDPNWY--KARLGNQEGMVPANYISLYPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AE  LL           P GAF++R+S+   G +S+SV+         +
Sbjct: 59  PWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVK-----EGSSV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVE-HYSELADGICCPLREPCVLQK 194
            H+RI     G  YI     F S++AL++ H  +   G+   L   CV  K
Sbjct: 114 LHFRIFFDPKGKYYIWTN-KFDSINALIDYHRHQTIYGVKALLLRDCVSSK 163


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score = 54.3 bits (129), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 32/83 (38%), Positives = 47/83 (56%), Gaps = 7/83 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  + R  AE+ L    +  G FL+R S+T  G YS+S+++  P    RIRH+++  L
Sbjct: 316 WYFGNMKRADAEQRLQDRAD-NGEFLVRGSETSSGDYSISMKM--PG---RIRHFKVNTL 369

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
            NG   I  R  F S+ AL+EHY
Sbjct: 370 PNGVFGIGQR-KFDSMDALLEHY 391


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score = 53.9 bits (128), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 57/183 (31%), Positives = 80/183 (43%), Gaps = 27/183 (14%)

Query: 50  LSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV--------AHGWLYEGLSR 100
           LS   GE   + +E  G W  V S+ SG    +    V  V           W +  +S+
Sbjct: 185 LSFSAGEVFVVHNELGGGWLWVTSQRSGESGIIVQDLVKPVEGEIDPNEGKVWFHGNVSK 244

Query: 101 EKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYIS 160
           E+A E L   G+ GG FLIR S    G YSLS R   P +  R R  + QR      Y+ 
Sbjct: 245 EEAAETLWKDGDIGG-FLIRNSDKNPGDYSLSFR--GPNTIQRFRIQKQQR-----QYVM 296

Query: 161 PRLTFPSLHALVEHYS--ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
               + SL A+V+HY   E+ DG    LR+P   +K             T  +S +N+++
Sbjct: 297 GGRYYNSLDAIVDHYKKEEIIDGF--KLRDPTAPKKF------KNQTTSTEDSSPMNYEE 348

Query: 219 LDR 221
           L R
Sbjct: 349 LRR 351


>UniRef50_Q85476 (recovered insertion mutant of B77) src (Fragment) n=2 Tax=Rous
           sarcoma virus RepID=Q85476_9RETR
          Length = 285

 Score = 53.9 bits (128), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 24/57 (42%), Positives = 36/57 (63%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           W +  ++R ++E LLL P NP G FL+R+S+T +G Y LSV     A    ++HY+I
Sbjct: 229 WYFGKITRRESERLLLNPENPRGTFLVRKSETTKGAYCLSVSDFDNAKGPNVKHYKI 285



 Score = 41.6 bits (96), Expect = 0.029,   Method: Compositional matrix adjust.
 Identities = 21/55 (38%), Positives = 32/55 (58%), Gaps = 1/55 (1%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVA 87
            T VAL  + +  +  LS + GE L I++  +GDWW   S  +G+  ++PS YVA
Sbjct: 84  TTFVALYDYESWTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVA 138


>UniRef50_Q5BXE5 SJCHGC04002 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BXE5_SCHJA
          Length = 240

 Score = 53.5 bits (127), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 36/95 (37%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W    L RE A ELL       G+FL+R S T  GC +LSVR+    +   I HY IQ+ 
Sbjct: 86  WYQALLPREIAFELL--AREEVGSFLVRNSATHPGCCALSVRVPNKDNPLGITHYLIQKT 143

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
             G         +PSL ALV H + + + + CPL+
Sbjct: 144 SQGVRLKGLDKEWPSLQALVTHLTVIPEMLPCPLK 178


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score = 53.5 bits (127), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 35/112 (31%), Positives = 56/112 (50%), Gaps = 10/112 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE++E+ +   G   G FL+RE +T    ++L V     A  + I HY ++  
Sbjct: 163 WFHGAISREESEQRMKAFGLRDGLFLVRE-RTEVNSFALCV-----AVKNDIYHYLLEMN 216

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG----PLPG 200
             G L I     F +L  +V+HYS   DG+ C L + C + +      P+PG
Sbjct: 217 TLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPG 268



 Score = 51.2 bits (121), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 37/113 (32%), Positives = 57/113 (50%), Gaps = 12/113 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SR  AE+LL   G   G+FL+R+S T  G Y LS+         +  HY I R 
Sbjct: 9   WYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQ-----GKKYHYIISRH 63

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
            +G + I     F S   L++++++  DG+   L++PC       LPG+  PP
Sbjct: 64  PDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQPCC-----RLPGQ--PP 109


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score = 53.5 bits (127), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 47/152 (30%), Positives = 67/152 (44%), Gaps = 20/152 (13%)

Query: 50  LSLRLGEPLTIIS--EDGDWWTVQSEVSG----------REYHMPSVYVAKVAHGWLYEG 97
           L+ R G+ +TI+   E+  W+ V+   SG          RE    S         W +  
Sbjct: 67  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 126

Query: 98  LSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWL 157
           +S ++A + L  P +  G FL+RES    G Y L V   R      + HYR+   D G L
Sbjct: 127 ISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRD-----VIHYRVLHRD-GHL 178

Query: 158 YISPRLTFPSLHALVEHYSELADGICCPLREP 189
            I   + F +L  +VEHYS+    IC  L  P
Sbjct: 179 TIDEAVFFCNLMDMVEHYSKDKGAICTKLVRP 210


>UniRef50_Q4TFA7 Chromosome 21 SCAF4724, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4TFA7_TETNG
          Length = 277

 Score = 53.5 bits (127), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 25/49 (51%), Positives = 31/49 (63%), Gaps = 6/49 (12%)

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           G YSLSV+      +  ++HYRI RLDN W YISP LTF  L  ++ HY
Sbjct: 200 GSYSLSVK------YRSVKHYRIYRLDNSWYYISPSLTFQCLEDMINHY 242


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score = 53.1 bits (126), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 44/155 (28%), Positives = 70/155 (45%), Gaps = 29/155 (18%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE  E LL   G P G+FL+RES +  G + LSV  +   S     H++I+R 
Sbjct: 9   WYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVS-----HFQIRRH 63

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSE----LADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            ++ +  I        L +L+EHY      L++G+   +          P+ G D PP  
Sbjct: 64  SEDAFFSIDENTKIHGLESLIEHYVNTKGILSEGLSLTV----------PVKG-DAPPDY 112

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
           +        ++  R+ L   A   G   ++SE L+
Sbjct: 113 S--------RRHGRTNLLHRATKEGNYKVVSEVLK 139


>UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y4_9METZ
          Length = 853

 Score = 52.8 bits (125), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 45/165 (27%), Positives = 72/165 (43%), Gaps = 33/165 (20%)

Query: 48  ARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELL 107
           A  S+  G+PL I S++    +   E      H+                +S +  E++L
Sbjct: 330 ANFSILEGDPLIIPSDEMLKISENDECKAELCHV---------------AISPDSVEKVL 374

Query: 108 LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYIS------- 160
            +     G FLIRES++    Y+LS+         RI+++RI R  +G L +        
Sbjct: 375 EMYNKEDGTFLIRESRSSENSYTLSL-----CHNQRIKNFRISRDTDGSLSLKDPAGSTA 429

Query: 161 --PRLTFPSLHALVEHYSELADGICCPLREPC----VLQKLGPLP 199
             P  +FPS+ ALVEH+    DG+   L+  C    V +  G +P
Sbjct: 430 EQPIKSFPSMAALVEHHKTEKDGLPTHLKINCSPKEVAKTAGAIP 474


>UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi sarcoma viral oncogene
           homolog 1 n=1 Tax=Ciona intestinalis RepID=UPI000180BC98
          Length = 432

 Score = 52.8 bits (125), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 2/93 (2%)

Query: 98  LSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWL 157
           +SRE+AE  LL  G   G FL+R+     G Y +S+  S      R+ +YR++   N   
Sbjct: 30  ISREEAETNLLERGENDGTFLVRKGTD--GEYRISLLSSTSDGSCRVYNYRVKLATNRTY 87

Query: 158 YISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            I    +FP++H LV +YS+   G+   L  PC
Sbjct: 88  SIDDTYSFPAVHQLVRYYSQKCSGLPSKLVAPC 120


>UniRef50_A9V5H9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5H9_MONBE
          Length = 318

 Score = 52.8 bits (125), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 31/83 (37%), Positives = 44/83 (53%), Gaps = 6/83 (7%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  + R+KAE +L   G   G FLIR +   R CY+L++         RI H  I+ +
Sbjct: 224 WFHMTVDRQKAESMLRKAGLQDGMFLIRPASKPR-CYALTM-----CRHGRILHNTIEAV 277

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
            + + Y+ P  TF SL  LVEHY
Sbjct: 278 GHRYRYVGPDRTFDSLADLVEHY 300


>UniRef50_Q380D8 AGAP001259-PA (Fragment) n=3 Tax=Culicidae RepID=Q380D8_ANOGA
          Length = 264

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 37/98 (37%), Positives = 53/98 (54%), Gaps = 4/98 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +E L R  +  L LL     G+FL+R+S T+  CY+LS+R+  P S  RI HY I R 
Sbjct: 142 WYHENLPRSLS--LQLLADKLPGSFLVRKSTTQPDCYALSLRVP-PGSGPRIAHYLIVRT 198

Query: 153 DN-GWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
              G+     +  F SL AL+ H+S + + +  PL  P
Sbjct: 199 STEGYKIKGFQKEFSSLRALIVHHSVMPEALPVPLAVP 236


>UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepID=HTK16_HYDAT
          Length = 757

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 39/127 (30%), Positives = 59/127 (46%), Gaps = 13/127 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL++ L R  A  +L       G+FLIR S    G Y L++   +     +  H++I+  
Sbjct: 287 WLHQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEK-----KTYHFQIKSR 341

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
            + W YI     F +L  LV+HY + ADG+      P +LQ   P+P  +       PT 
Sbjct: 342 ADRWFYIDDGPLFETLPHLVDHYMQYADGL------PTLLQ--FPVPSAENRKRPLPPTP 393

Query: 213 SLNWKKL 219
           + N  KL
Sbjct: 394 TKNQLKL 400



 Score = 50.8 bits (120), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 33/106 (31%), Positives = 51/106 (48%), Gaps = 6/106 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++RE A ++LL  G   G FLIR+       Y LS+         +I H++I  L
Sbjct: 10  WYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFR-----SQILHFQINCL 64

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
            +    I     F  L  L+ +Y  ++DG+ C L + CV  K+ PL
Sbjct: 65  GDNKFSIDNGPIFQGLDMLISYYKVISDGLPCKLVDFCV-GKIAPL 109


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 44/128 (34%), Positives = 56/128 (43%), Gaps = 23/128 (17%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSR  AE LL+     G ++L+R S TR G YSLSV+       D ++H++I   
Sbjct: 14  WYHGDLSRHMAEALLMANAEDG-SYLLRSSATRVGEYSLSVKCK-----DSVKHFQI--- 64

Query: 153 DNGW---LYISPRLTFPSLHALVEHYSEL-----ADGICCPLREPCVLQKLGPLPGKDTP 204
             GW    Y      F SL   VEH++         GI   LR P     L P    D  
Sbjct: 65  --GWDGKQYQFGMGVFQSLQEFVEHFANQPLIGGESGILTALRHPYSRNVLEP----DVY 118

Query: 205 PPVTVPTS 212
             VTV  S
Sbjct: 119 DTVTVHAS 126


>UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QBP3_IXOSC
          Length = 626

 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 44/132 (33%), Positives = 67/132 (50%), Gaps = 11/132 (8%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           RG+T       S  D   V++Q         AL SF A E+  LSL  G    ++ + G+
Sbjct: 157 RGETGYLCARCSLLD---VALQVTTPARVVTALYSFQAIEKGDLSLEAGREYVVLDDSGE 213

Query: 67  -WWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRE 121
            WW V+ + SG    +PS YV + A    H W    +SR++AE++L       GAF++R 
Sbjct: 214 HWWQVR-DGSGAVGFIPSNYVEQKAGLWQHEWYAGDMSRQRAEQVLRQETKE-GAFVVRN 271

Query: 122 SQTRRGCYSLSV 133
           S T +G ++LS+
Sbjct: 272 SST-QGFFTLSL 282


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 32/87 (36%), Positives = 48/87 (55%), Gaps = 8/87 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W  E ++R +AE+LL   G P GAFLIRES +++GCY+ SV      +   ++H  I   
Sbjct: 299 WFVEDINRVQAEDLLY--GKPDGAFLIRES-SKKGCYACSV-----VADGEVKHCVIYST 350

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELA 179
             G+ +  P   + SL  LV HY + +
Sbjct: 351 ARGYGFAEPYNLYSSLKELVLHYQQTS 377


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score = 51.6 bits (122), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 11/105 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R+++EELLL      G+F++R S++R G Y+LSV  +     + +  YRI   
Sbjct: 6   WYHGRVNRQQSEELLL-SAAVDGSFVVRASESRAGAYALSVLFN-----NSVHTYRILPT 59

Query: 153 DNGWLYISP-----RLTFPSLHALVEHYSELADGICCPLREPCVL 192
           +N  L +       +  F SL  LV  Y    +G+ C L  P  L
Sbjct: 60  ENNTLAVQTVNGVQQRKFKSLTELVHEYRNSQNGLVCGLSNPVGL 104


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score = 51.2 bits (121), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 61/193 (31%), Positives = 87/193 (45%), Gaps = 40/193 (20%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQ---PERHKVTAVALGSFPAGEQARLSLRLGEP---- 57
           SS+   S  + S+ G D E    +   PER K +     SF       LSLRL  P    
Sbjct: 552 SSKIYYSEETSSNQGNDDEEEHKEVRRPERKKKS-----SFSRVLLTDLSLRLRPPTFPD 606

Query: 58  ---LTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS-REKAEELL----LL 109
              L +++            +G + H+      K  HG L  G   R+ AE LL    + 
Sbjct: 607 RLVLVLVNFQAS--------NGMDQHV----TEKWFHGKLGAGRDGRQIAERLLSEYCME 654

Query: 110 PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTFP 166
            G P G+FL+RES+T  G Y+LS   S      R++H RI  R + G    Y++  L F 
Sbjct: 655 TGAPDGSFLVRESETFVGDYTLSFWRS-----GRVQHCRIHSRQEAGSPKFYLTDNLVFD 709

Query: 167 SLHALVEHYSELA 179
           +L AL+ HY ++A
Sbjct: 710 TLFALINHYQQVA 722


>UniRef50_Q22070 Protein T01E8.3, partially confirmed by transcript evidence n=4
           Tax=Chromadorea RepID=Q22070_CAEEL
          Length = 1350

 Score = 51.2 bits (121), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 43/134 (32%), Positives = 67/134 (50%), Gaps = 16/134 (11%)

Query: 93  WLYEGLSREKAEELL-LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W      +EKAEELL L+P +  GAFLIR S T    Y LS+++     W    HYR++R
Sbjct: 715 WFSATADKEKAEELLSLVPED--GAFLIRTSSTDSSVYVLSLKVD-GEFW----HYRLKR 767

Query: 152 LDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
             +G +++  +  F +L+ +VE Y+  E   GI   LR P   + +  L  +        
Sbjct: 768 --DGRIFVVNQKVFENLNQIVEFYANREFVRGI--SLRFPVNEKDISHLTAE--LAEART 821

Query: 210 PTSSLNWKKLDRSL 223
           P   ++ K LD+ +
Sbjct: 822 PGCYMDLKDLDKEV 835


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score = 51.2 bits (121), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 33/99 (33%), Positives = 48/99 (48%), Gaps = 7/99 (7%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE AEE+L   G+  G FL+RES +  G Y LSV          + HY I+R 
Sbjct: 9   WFHGKISREDAEEILRREGS-DGVFLVRESSSSEGDYVLSVLFK-----GEVVHYAIRRH 62

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            D+ +  I        L +L+EHY +    +   L+  C
Sbjct: 63  GDDAFFSIHDHTPIHGLDSLIEHYQKDKGNLVTRLQVIC 101



 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 37/131 (28%), Positives = 56/131 (42%), Gaps = 12/131 (9%)

Query: 99  SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLY 158
           ++E  E L  L  +  G +L+R S  +       +  + P      +H+ IQR  + WLY
Sbjct: 323 NKENGECLDGLEQSTSGTYLVRYSAKQNVDVLTMLYDNEP------KHFIIQRQQD-WLY 375

Query: 159 ISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
           I       SL  L+EHY+  +DG+   LR P       P P    P   T+P S     +
Sbjct: 376 IDEGPYMNSLEHLIEHYTRFSDGLPINLRFPVT-----PGPKPPIPAFATIPKSKHRMHR 430

Query: 219 LDRSLLFLEAP 229
            D +   L +P
Sbjct: 431 TDGTTAALPSP 441


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score = 51.2 bits (121), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 14/111 (12%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL +   R  AEE+L   G P G FLIR      G Y+LS+     A  + ++H  I   
Sbjct: 337 WLLKDAKRRNAEEML--KGAPSGTFLIRARDA--GHYALSI-----ACKNIVQHCLIYET 387

Query: 153 DNGWLYISPRLTFPSLHALVEHYS-----ELADGICCPLREPCVLQKLGPL 198
             G+ + +P   + +L +LVEHY+     E  D +   LR P +  K  PL
Sbjct: 388 STGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPVLYWKNNPL 438


>UniRef50_A7T8K3 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T8K3_NEMVE
          Length = 402

 Score = 50.8 bits (120), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 31/94 (32%), Positives = 49/94 (52%), Gaps = 2/94 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE   E+L    +  G+F +R+SQ++ GC++L+VR+          +Y I  +
Sbjct: 270 WYMPGIPREFIMEML--QASEEGSFFVRDSQSKPGCHALTVRVPTEVHASGFGNYLITPI 327

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
             G        TF  L +L+E+YS  ADG+ C L
Sbjct: 328 PEGVKLEGFSRTFTDLVSLIEYYSYHADGLPCRL 361


>UniRef50_UPI00016E9C47 UPI00016E9C47 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9C47
          Length = 477

 Score = 50.4 bits (119), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 16/160 (10%)

Query: 12  SPSPSSSGPD---QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDW 67
           +P+  + GP+   Q P    P             P   Q  L L+  E  TI+   D +W
Sbjct: 189 TPTEENPGPNVLLQAPEPQGPSVGMTVTAEYNYLPMTTQD-LELKKDEEYTILEMSDPNW 247

Query: 68  WTVQSEVSGREYHMPSVYVAKVAHG-----WLYEGLSREKAEELLLLPGNPGGAFLIRES 122
           W  + +  G E ++PS YV +  +G     W  +  +R +AE+LL      GG FL+R+S
Sbjct: 248 WRARDKY-GNEGYIPSNYVVEAENGLERFDWFCKNTNRSQAEKLLRTENKDGG-FLVRDS 305

Query: 123 QTRRGCYSLSVRLSRPA--SWDRIRHYRIQRLDNGWLYIS 160
            +R G Y++S+ LS+    +    RHY I     G  Y++
Sbjct: 306 -SRPGKYTVSL-LSKSGGDTGASCRHYNICTTPQGHFYLA 343


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score = 50.4 bits (119), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 13/125 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SR KA +L+ L G  G G FL+R+S+TRRG Y L+          R +H R+  
Sbjct: 388 WFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLTFNFQ-----GRAKHLRLSL 442

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE----LADGICCPLR--EPCVLQKLGPLPGKDTPP 205
            + G   +   L F S+  ++ H+      L  G  C +R     V+    P PG     
Sbjct: 443 TERGQCRVQ-HLRFSSITEMLHHFHRYPIPLECGATCDVRLSSYVVVLPQAPAPGSSPAL 501

Query: 206 PVTVP 210
           PV +P
Sbjct: 502 PVPLP 506


>UniRef50_A8WUN8 C. briggsae CBR-SHC-2 protein n=8 Tax=Caenorhabditis
           RepID=A8WUN8_CAEBR
          Length = 620

 Score = 50.4 bits (119), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 33/103 (32%), Positives = 56/103 (54%), Gaps = 6/103 (5%)

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW-LYISP-RLTFP 166
           L   P GAF+IR S+++  C +LS+R+    +   I HY I R ++G+ L +S  +  FP
Sbjct: 453 LLSQPEGAFVIRYSESKSKCLALSMRVPVTHNPAGISHYLIIRNEHGFRLKLSATKKPFP 512

Query: 167 SLHALVEHYSELADGICCPLR----EPCVLQKLGPLPGKDTPP 205
           +L  ++ HYS L   + C L     +    ++L P+  ++ PP
Sbjct: 513 TLQMMLTHYSVLESHLPCTLHFVQWQKTNFKQLQPMNTQERPP 555


>UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleostomi
           RepID=ZAP70_HUMAN
          Length = 619

 Score = 50.4 bits (119), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 35/98 (35%), Positives = 46/98 (46%), Gaps = 5/98 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           + Y  +SR +AEE L L G   G FL+R+     G Y LS+         R  H+ I+R 
Sbjct: 10  FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            NG   I+          L E YS   DG+ C LR+PC
Sbjct: 65  LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102



 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 9/108 (8%)

Query: 86  VAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           +A  AH    W +  L+RE+AE  L       G FL+R  +  +G Y+LS+   +     
Sbjct: 153 IATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSLIYGKT---- 207

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            + HY I +   G   I     F +L  LVE+    ADG+   L+E C
Sbjct: 208 -VYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEAC 254


>UniRef50_A7RU23 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RU23_NEMVE
          Length = 814

 Score = 50.1 bits (118), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 31/94 (32%), Positives = 49/94 (52%), Gaps = 2/94 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE   E+L    +  G+F +R+SQ++ GC++L+VR+          +Y I  +
Sbjct: 682 WYMPGIPREFIMEML--QASEEGSFFVRDSQSKPGCHALTVRVPTEVHASGFGNYLITPI 739

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
             G        TF  L +L+E+YS  ADG+ C L
Sbjct: 740 PEGVKLEGFSRTFTDLVSLIEYYSYHADGLPCRL 773


>UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q3U8_BRUMA
          Length = 1284

 Score = 50.1 bits (118), Expect = 8e-05,   Method: Composition-based stats.
 Identities = 36/108 (33%), Positives = 56/108 (51%), Gaps = 12/108 (11%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W  E   R +AEELL       GAFL+R S T +  + LS+R+        I HY ++R 
Sbjct: 677 WFCEKTDRNRAEELLNTV-QQDGAFLLRFSSTDKNVFVLSLRVD-----GEIWHYHLKR- 729

Query: 153 DNGWLYISPRLTFPSLHALVEHYS--ELADGICC--PLREPCVLQKLG 196
            +G +++  +  F +L+ +VE+YS  E   GIC   P+ E  ++   G
Sbjct: 730 -DGRIFVVNQTIFENLNQIVEYYSTREFVRGICLKYPVGEDTIIGSAG 776


>UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E4312
          Length = 350

 Score = 50.1 bits (118), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 40/115 (34%), Positives = 61/115 (53%), Gaps = 12/115 (10%)

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           PS+ V  V+  W + G+SR++A+ L+   G   G FLIRESQ    C+ LS+     +  
Sbjct: 239 PSLAV-HVSQPWFHGGVSRKEAQRLIEKQGLVDGMFLIRESQQHGQCFVLSL-----SHQ 292

Query: 142 DRIRHYRIQRLDNG---WLYISPRLT-FPSLHALVEHYSELADGIC-CPLREPCV 191
            +I+HY +   ++G   +  I   LT F  L  LVE + ++  GI    L+ PCV
Sbjct: 293 LKIKHYLVIPCEDGGRKYFTIDDGLTLFIDLLQLVE-FHQINKGILPVCLKHPCV 346


>UniRef50_UPI000155BA92 PREDICTED: similar to Fyn-related kinase, partial n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BA92
          Length = 186

 Score = 49.7 bits (117), Expect = 9e-05,   Method: Compositional matrix adjust.
 Identities = 37/108 (34%), Positives = 54/108 (50%), Gaps = 12/108 (11%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEVSG-------REYHMPSVYVAK 88
           VAL  + A     LS   G+ L ++      WW  +    G        + ++P+ Y+AK
Sbjct: 79  VALFDYRARTAEDLSFVAGDRLQVLDASHPGWWLARLLGHGGDDPGQQSQGYVPANYLAK 138

Query: 89  ----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
                A  W +  + R  AE+ LL  GN  GAFLIRES++++G YSLS
Sbjct: 139 DQSLQAEQWFFGAIKRVDAEKQLLYSGNRPGAFLIRESESQKGDYSLS 186


>UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n=1 Tax=Ciona intestinalis
           RepID=UPI000180C4D7
          Length = 525

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 6/86 (6%)

Query: 55  GEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA----KVAHGWLYEGLSREKAEELLLLP 110
            E + I+++ GDWW  +S  +G+E  +PS YVA         W + G   EK  E +L+ 
Sbjct: 112 AESICILNKQGDWWKARSRETGQEGFIPSNYVALEDSIECERWFF-GKKSEKECERMLVQ 170

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLS 136
             P G ++I ES+T  G Y +S+ + 
Sbjct: 171 QKP-GTYMITESKTEPGIYRISLTIQ 195


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 16/127 (12%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGN 112
           ++ E L I +E  D ++++ + S   +   + YV  +          R +AEE+L   G 
Sbjct: 591 KINEWLGIKNEADDSYSLEEDESSPHHDESTWYVGDI---------KRSQAEEMLR--GT 639

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             G FLIRESQT++G Y+ SV +         +H  + +   G+ +  P   + SL  LV
Sbjct: 640 CDGTFLIRESQTQKGSYACSVVVD-----GDTKHCVVYKTVTGYGFAEPYNLYSSLKDLV 694

Query: 173 EHYSELA 179
            HY  ++
Sbjct: 695 LHYKNVS 701


>UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction protein lnk-realted n=1
           Tax=Nasonia vitripennis RepID=UPI00015B58E2
          Length = 458

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 7/86 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  L R  A +L+L     G G FL+R+S+TR+G Y L+          R +H R+  
Sbjct: 270 WFHGTLPRSDAAQLVLHNATEGHGTFLVRQSETRKGEYVLTFNFQ-----GRAKHLRMTL 324

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE 177
            D G   +   L+FP+++ +++H+ +
Sbjct: 325 TDQGHCRVQ-HLSFPAIYDMLDHFRQ 349


>UniRef50_Q8MQW8 Protein sprint n=6 Tax=Drosophila RepID=SPRI_DROME
          Length = 1790

 Score = 49.3 bits (116), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 35/102 (34%), Positives = 53/102 (51%), Gaps = 4/102 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ R  A  + LL G   G F++R S ++    ++SVRL +  +   I HY IQ  
Sbjct: 474 WFLPGIQRSGA--VHLLQGKEEGTFIVRGS-SQPNTMAVSVRLPQ-DTGPYIEHYLIQSH 529

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
           DN     S R TF S+ +L+ HY++  D +   L  P VL++
Sbjct: 530 DNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLRE 571


>UniRef50_A9V545 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V545_MONBE
          Length = 1565

 Score = 49.3 bits (116), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 34/132 (25%), Positives = 64/132 (48%), Gaps = 19/132 (14%)

Query: 58   LTIISEDGDWWTVQSEVSGREYHMPS----------VYVAKVAHGWL---YEGLSREKAE 104
            + ++ E+  +   ++E   RE H+ +          +Y+ K    W+    E   R  A+
Sbjct: 957  VIMVDEEMFYLVSKNEQDQRECHVFTTEGHDSFELVMYLQKTFQRWVEHTREARDRAMAK 1016

Query: 105  ELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNG-WLYISPRL 163
               L    P GAF++R S ++ GC++LSV+ +     D++ HY ++RL +G + +     
Sbjct: 1017 LTNLDHPVPNGAFVLRPSTSQPGCFALSVKFN-----DQVTHYLVERLTDGKFSFKDSDR 1071

Query: 164  TFPSLHALVEHY 175
             F +L  L+ HY
Sbjct: 1072 AFLTLRDLIVHY 1083


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score = 49.3 bits (116), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 32/78 (41%), Positives = 47/78 (60%), Gaps = 8/78 (10%)

Query: 98  LSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWL 157
           ++R+ AEELL   G+  GAFLIRES+   G YSLSV+       D ++H+++ R D    
Sbjct: 28  VTRDGAEELLKNDGD--GAFLIRESEGTPGDYSLSVKFV-----DGVQHFKVLR-DGAGK 79

Query: 158 YISPRLTFPSLHALVEHY 175
           Y    + F SL+ LVE++
Sbjct: 80  YFLWVVKFNSLNQLVEYH 97


>UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_SCHMA
          Length = 1264

 Score = 49.3 bits (116), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 7/97 (7%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  + R +AE  L   GN  GAFL+R  +  R  Y LS+      S +  +HYRI+  
Sbjct: 202 WYHHTIRRYEAESRLASEGNQDGAFLVRYRKEDR-TYVLSL-----TSQNEPKHYRIEEY 255

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            + W  I     F ++  L++HY    DG+ C L++P
Sbjct: 256 LSRW-SIEGGQYFETIMELIDHYHFRQDGLLCKLQKP 291



 Score = 44.7 bits (104), Expect = 0.003,   Method: Composition-based stats.
 Identities = 33/101 (32%), Positives = 47/101 (46%), Gaps = 11/101 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           + Y  ++RE+AEELL   G   G FL+RES  R   Y++S+         R+ HY ++R 
Sbjct: 49  YFYGKITREQAEELLFTNGANEGLFLLRESVNRN--YAVSI-----CHLGRVHHYNVERH 101

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICC----PLREP 189
            +    I     F     LV+H+S   DG       PL  P
Sbjct: 102 TDCSYRIQTGHKFIGPVELVQHHSTQLDGFLTLAQLPLNRP 142


>UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS
          Length = 938

 Score = 49.3 bits (116), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 10/103 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE A++LL   G   G FL+RES T  G + LS+        + + HY+++R 
Sbjct: 9   WFHANLSREAADDLLR-QGYEDGTFLVRESSTAAGDFVLSILCQ-----EEVCHYQVRRH 62

Query: 153 -DNGWLYISPRLTFPSLH---ALVEHYSELADGICCPLREPCV 191
            ++ +  I   +    LH    LV++Y + A+G+   L  P +
Sbjct: 63  GEDAFFSIDDEMQTKILHGLETLVDYYQQGANGLPTKLTVPLI 105


>UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound protein 14 isoform 1 n=1
           Tax=Pan troglodytes RepID=UPI0000E1F79D
          Length = 491

 Score = 48.9 bits (115), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 38/158 (24%), Positives = 76/158 (48%), Gaps = 17/158 (10%)

Query: 44  AGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG------WLYEG 97
           +G+++R+     E L++  E+G  W   +   G        ++  ++        W +  
Sbjct: 335 SGQKSRVIENPTEALSVAVEEGLAWRSSATNMGIHLKQSFAFIHPISLAIHRSQPWFHHK 394

Query: 98  LSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL-DNGW 156
           +SR++A+ L++  G   G FL+R+SQ+    + LS+     +   +I+H++I  + D+G 
Sbjct: 395 ISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSM-----SHGQKIKHFQIIPVEDDGE 449

Query: 157 LYIS---PRLTFPSLHALVEHYSELADGIC-CPLREPC 190
           ++ +       F  L  LVE Y +L  G+  C L+  C
Sbjct: 450 MFHTLDDGHTRFTDLIQLVEFY-QLNKGVLPCKLKHYC 486


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 32/104 (30%), Positives = 54/104 (51%), Gaps = 11/104 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE A++LL   G   G FL+RES T  G + LS+        + + HY+++R 
Sbjct: 10  WFHGNLSREAADDLLK-QGYEDGTFLVRESSTAAGDFVLSLLCQ-----EEVCHYQVRRH 63

Query: 153 --DNGWLYISPRLTFPSLH---ALVEHYSELADGICCPLREPCV 191
             ++ +  I  ++    LH    LV++Y + A+G+   L  P +
Sbjct: 64  GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLI 107


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score = 48.5 bits (114), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 32/100 (32%), Positives = 48/100 (48%), Gaps = 6/100 (6%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W + GL+R++   L    G   G FLIRESQ   G + LS   ++     +++HY+I  +
Sbjct: 660 WFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSFSHNQ-----KVKHYQINMV 714

Query: 153 DNGWLYISPRLT-FPSLHALVEHYSELADGICCPLREPCV 191
           ++G   I    T F  L  LVE Y   + G+   L   C 
Sbjct: 715 EDGVYTIDDGGTRFTDLIQLVEFYQLNSGGLPTRLLHICT 754


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score = 48.5 bits (114), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 20/121 (16%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE A+ELL   G   G FL+RES T  G + LS+          + HY+++R 
Sbjct: 10  WYHGNLSREAADELLK-QGYEDGTFLVRESSTAAGDFVLSLLCQ-----GEVCHYQVRRH 63

Query: 153 --DNGWLYISPRLTFPSLH---ALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
             ++ +  I  ++    LH    LV++Y + A+G+   L  P +         +D PP  
Sbjct: 64  GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLI---------RDLPPHN 114

Query: 208 T 208
           T
Sbjct: 115 T 115


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 5/98 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           +L++ + R  A E L   G   G+FLIR +  + G Y+L++   +        HY +   
Sbjct: 292 FLHKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTPY-----HYEVVCE 346

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            + W +I     F +L A+V+HY+  ADG+   L  P 
Sbjct: 347 SDCWYFIDDGPLFDTLPAVVDHYTIFADGLPTTLLYPV 384


>UniRef50_P50745 SH2B adapter protein 3 n=2 Tax=Rattus norvegicus RepID=SH2B3_RAT
          Length = 368

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 22/159 (13%)

Query: 93  WLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SR +A +L+ L G +  G FL+R+S++RRG Y L+  L       R +H R+  
Sbjct: 119 WFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGEYVLTFNLQ-----GRAKHLRLVL 173

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE----LADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            + G   +   L FPS+  ++ H+      L  G  C +R    +  +   PG+   P V
Sbjct: 174 TERGQCRVQ-HLHFPSVVDMLRHFQRSPIPLECGAACDVRLSGYVVVVSQAPGRK--PKV 230

Query: 208 ---------TVPTSSLNWKKLDRSLLFLEAPASGEASLL 237
                    T  T   +W +L   ++ + +P S    L 
Sbjct: 231 VSRGGVTASTARTKLPSWLRLLHGVIHVISPGSSNTVLF 269


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 9/103 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-- 150
           W + G++RE+A  ++ + G   G +L+RESQT  G + L+          R++HY+IQ  
Sbjct: 632 WFHHGINREEANNMMHMQGMVDGLYLVRESQTFPGTFVLTF-----CHDQRVKHYQIQPN 686

Query: 151 RLDNGWLYI--SPRLTFPSLHALVEHYSELADGICCPLREPCV 191
            +D+   Y        F  L  LVE Y      +   L  PC 
Sbjct: 687 VIDDKTFYSLDEGETKFGDLVQLVEFYQINRGALPHSLTHPCT 729


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 13/129 (10%)

Query: 93  WLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SR KA +L+ L G +  G FL+R+S+TRRG Y L+      A     +H R+  
Sbjct: 371 WFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIA-----KHLRLSL 425

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE----LADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            + G   +   L FPS+  ++ H+      L  G  C +R    +  +   PG      V
Sbjct: 426 TERGQCRVQ-HLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSSN--TV 482

Query: 208 TVPTSSLNW 216
             P S  +W
Sbjct: 483 LFPFSLAHW 491


>UniRef50_Q9VHC3 Blistery n=8 Tax=Sophophora RepID=Q9VHC3_DROME
          Length = 720

 Score = 47.8 bits (112), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 42/123 (34%), Positives = 57/123 (46%), Gaps = 16/123 (13%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR--PASWDRIRHYRIQ 150
           W    L+RE A  + LL     G FL+R+S T +  Y L VR+S+  P S + +RH+ I+
Sbjct: 458 WYKPNLTREDA--IALLASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQELVRHFLIE 515

Query: 151 RLDNGWLY--ISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
               G           F SL ALV  +S         L  PC+L+    LP +D  PPV 
Sbjct: 516 PTKGGVHLKGCDDEPVFTSLSALVFEHS------ISQLALPCLLR----LPDRDIVPPVR 565

Query: 209 VPT 211
             T
Sbjct: 566 ATT 568


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 47.8 bits (112), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 28/90 (31%), Positives = 50/90 (55%), Gaps = 7/90 (7%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  L+  +AEELL    +  G+FL+R S+++ G +++SV+ +      ++ H +IQ  
Sbjct: 5   WFHSSLNGSQAEELLTPLAD--GSFLVRPSESKHGDFTISVKCN-----GKVTHIKIQND 57

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGI 182
            + +L I     FP+L +LV HY    + I
Sbjct: 58  GDSFLLIGSPDPFPTLESLVSHYRNTPNSI 87


>UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2RUZ0_DANRE
          Length = 906

 Score = 47.4 bits (111), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 29/84 (34%), Positives = 45/84 (53%), Gaps = 7/84 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  LSR KA +L+L  G    G FL+R+S+TRRG Y L+      A     +H R+  
Sbjct: 715 WFHGTLSRLKAAQLVLAGGMASHGVFLVRQSETRRGEYVLTFNFQGKA-----KHLRLSL 769

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
            ++G   +   L F S+  ++EH+
Sbjct: 770 NEDGQCRVQ-HLWFQSIFDMLEHF 792


>UniRef50_UPI00019273B6 PREDICTED: similar to Phosphatidylinositol 3-kinase regulatory
           subunit alpha n=1 Tax=Hydra magnipapillata
           RepID=UPI00019273B6
          Length = 401

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 5/83 (6%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL+  L RE+  E+L     P G FL+R+S+    C SL      P    +I+H  I + 
Sbjct: 299 WLFGELEREQIVEML--ENKPNGTFLVRKSKQYTYCISLVHDKGNPP---KIKHIPILKG 353

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
            +G+ +  P   +P+L +L+ HY
Sbjct: 354 PHGYGFAEPHNIYPTLQSLINHY 376



 Score = 42.4 bits (98), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 31/104 (29%), Positives = 52/104 (50%), Gaps = 10/104 (9%)

Query: 96  EGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNG 155
           E  S+E  E  L L G   G+FL+R+S+ R G ++L+V         R R  +I + +  
Sbjct: 15  EKRSKELREVSLALRGKCDGSFLVRKSENRLGEWTLTV-----MKDGRERFIKIMQHNGR 69

Query: 156 WLYISPRLTFPSLHALVEHY-----SELADGICCPLREPCVLQK 194
           + +    L F SL  L+E++     +E+   +   L+ PC+ QK
Sbjct: 70  FGFQISLLNFSSLKFLIEYFKDHSLNEMNSNLDTCLKYPCIKQK 113


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 31/101 (30%), Positives = 46/101 (45%), Gaps = 7/101 (6%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           + +  + R +AE  +   GN  G FLIR+S +  G Y LSV     A      H++I+  
Sbjct: 5   FFHGSVPRAEAEAKVQRGGN--GVFLIRQSSSDSGSYVLSVGYQGEA-----LHFKIKNE 57

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
              W  I     F  L  L EH+    DG+ C L  P +++
Sbjct: 58  GECWFSIDEGPVFEGLADLTEHFVHFPDGLPCNLTSPVLVR 98


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 30/83 (36%), Positives = 47/83 (56%), Gaps = 7/83 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LS ++AE L+L  G   G+FL+RESQ++ G + LSVR       D++ H  I+  
Sbjct: 58  WFHGNLSGKEAERLILERG-KNGSFLVRESQSKPGDFVLSVRTE-----DKVTHVMIRWH 111

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
           +N +  +     F +L  L+EHY
Sbjct: 112 ENKY-DVGGGQKFGTLCELIEHY 133


>UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n=3 Tax=Schistosoma
           RepID=C1LZF7_SCHMA
          Length = 234

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 32/224 (14%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTI--ISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A A   F A  +  L  + G  L I  + +D +W+  + E  GR   +P  Y+    H
Sbjct: 1   MEAEASYDFVANAEDELGFKKGSLLKILCVEDDPNWYLAEQE--GRTGLIPCNYITMRPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AEE L            P GAF++R+S+     +SLSV+         +
Sbjct: 59  PWYIRHCSRMEAEERLQEIDQETAQHLQPDGAFILRQSEADGKGFSLSVKQGCE-----V 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
            H+++ + D    Y      F S++ L++H+ + +            + +   L   D  
Sbjct: 114 LHFKVLQ-DEAGKYFFWLSKFDSINQLIDHHRKTS------------ISRNRLLTLVDLV 160

Query: 205 PPVTVPTSSLNWKKLDRSL--LFLEAPASGEASLLSEGLRESLS 246
           P    PT+   + +LDR +     E   +GE SL    + E +S
Sbjct: 161 PSKRFPTNVRKY-QLDRVIARFDFETKGAGELSLHRGDVIEVIS 203


>UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYM5_SCHMA
          Length = 670

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 57/213 (26%), Positives = 79/213 (37%), Gaps = 57/213 (26%)

Query: 41  SFPAGEQARLSLRLGEPLTIISEDGD-WWTVQSEVSGREYHMPSVYVAKVA--------H 91
           +F   +   L     E L II+   D  W       G    +P  YV + A        H
Sbjct: 22  TFKKDKNEDLPFSKNETLEIINIGKDPNWAHAKNAFGETGLIPLNYVQRKADILENLKDH 81

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSV------------------ 133
            W +  +SR ++E LL   G+P G+FLIRES    G  +L V                  
Sbjct: 82  CWYHGRISRAESESLL--SGSPVGSFLIRESDLYSGGLTLCVVGPACAVGSPDTTEHQNS 139

Query: 134 RLSRPASWDRIRHYRIQRL-------DNGWLYISPRLT------------FPSLHALVEH 174
            ++ P +   ++HYRI R        +    Y +P +             F SL  LV+ 
Sbjct: 140 TVTPPNTMTNVQHYRIVRRPFKATPSNQHSEYSTPLICSKIHYTLDETDWFSSLLELVQF 199

Query: 175 YSELADGICCPLREPC---------VLQKLGPL 198
           YSE   G+ C L  P           LQK G L
Sbjct: 200 YSEPKRGLVCALLHPVPDMQRKRLSELQKFGYL 232


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 38/125 (30%), Positives = 61/125 (48%), Gaps = 16/125 (12%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W + GLS  +AE LLL  G   G +L+RES +  G +++SV+    A+ D++ H  I   
Sbjct: 140 WFHAGLSGPEAERLLLAEGK-HGTYLVRESHSSPGQFAISVK----AADDKVIHVMIYSK 194

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
            + +  I    TF ++  L+EHY+          R P V Q    +  K   P   VP +
Sbjct: 195 SDKF-DIGGGATFSTISELLEHYT----------RNPMVDQAGTVVNLKQLLPSTRVPAT 243

Query: 213 SLNWK 217
           S++ +
Sbjct: 244 SIDIR 248


>UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi RepID=SH2B3_HUMAN
          Length = 575

 Score = 47.4 bits (111), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 11/100 (11%)

Query: 93  WLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SR KA +L+ L G +  G FL+R+S+TRRG Y L+      A     +H R+  
Sbjct: 364 WFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIA-----KHLRLSL 418

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE----LADGICCPLR 187
            + G   +   L FPS+  ++ H+      L  G  C +R
Sbjct: 419 TERGQCRVQ-HLHFPSVVDMLHHFQRSPIPLECGAACDVR 457


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score = 47.0 bits (110), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 49/173 (28%), Positives = 74/173 (42%), Gaps = 42/173 (24%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVYV------ 86
            VAL SF +     LS   G+ L I+     D +W+  ++   G+   +P  Y+      
Sbjct: 223 VVALYSFSSTNDQELSFEKGDRLEILDRPPSDPEWYKARN-AQGQVGLVPRNYLQELSEY 281

Query: 87  ---------------AKVAHG---------WLYEGLSREKAEELLLLPGNPGGAFLIRES 122
                          ++VA G         W Y  ++R   + LL   G+ G  FLIR+S
Sbjct: 282 LTQPFLDRKQEPMERSQVAMGDKPHLVDKPWYYGSITRYMCDNLLNQRGHDGD-FLIRDS 340

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           +T  G YS+S  L  P    R +H+R+     G LY   +  F +L  LV+HY
Sbjct: 341 ETNVGDYSVS--LKAPG---RNKHFRVHV--EGALYCIGQRKFHTLDQLVDHY 386


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score = 47.0 bits (110), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 38/165 (23%)

Query: 42  FPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVYVAKVAHG------ 92
           F +  +  L+   GE + +I +   D +WW  ++   G+   +P  YV  ++ G      
Sbjct: 206 FSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSDGPALHPA 264

Query: 93  --------------------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
                               W Y  ++R +AE  L   G  G  FLIR+S++    +S+S
Sbjct: 265 HAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGD-FLIRDSESSPSDFSVS 323

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           ++ S      + +H+++Q +DN  +Y   +  F ++  LVEHY +
Sbjct: 324 LKAS-----GKNKHFKVQLVDN--VYCIGQRRFHTMDELVEHYKK 361


>UniRef50_B3S2E5 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S2E5_TRIAD
          Length = 102

 Score = 47.0 bits (110), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 23/56 (41%), Positives = 33/56 (58%), Gaps = 1/56 (1%)

Query: 135 LSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           +S+  S  +IRHYRI++ +  + YIS    FPSLH LV+H+S     +C  L   C
Sbjct: 1   MSQSKSVTQIRHYRIKKANEKY-YISSTKLFPSLHELVKHHSVEYGSLCTTLSRSC 55


>UniRef50_B4JFU1 GH19392 (Fragment) n=6 Tax=cellular organisms RepID=B4JFU1_DROGR
          Length = 1708

 Score = 47.0 bits (110), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 42/135 (31%), Positives = 60/135 (44%), Gaps = 14/135 (10%)

Query: 67   WWTVQSEVSGREYHMPSVYVA--------KVAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
            + T+ S       H P+  VA          A  W    LSRE A  LLL    P G F+
Sbjct: 1410 YQTIASRQQLNSGHSPTFEVAPDLVKFARNSAKFWYKSLLSREDAIALLL--NAPPGTFV 1467

Query: 119  IRESQTRRGCYSLSVRLSRP--ASWDRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEH 174
            +R+S T +  Y L +R+++P   S + +RH+ I+    G          TF SL AL+  
Sbjct: 1468 VRDSTTYKNAYGLVLRVAQPPAGSQELVRHFLIEPTQRGVRLKGCENEPTFTSLSALIYE 1527

Query: 175  YSELADGICCPLREP 189
            +S     + C LR P
Sbjct: 1528 HSINKLALPCLLRIP 1542


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score = 47.0 bits (110), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 28/88 (31%), Positives = 48/88 (54%), Gaps = 7/88 (7%)

Query: 93  WLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  L+R +A +L+L  G +  G FL+R+S+TR+G + L+      A     +H R+  
Sbjct: 439 WFHGTLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTFNFQGKA-----KHLRMTL 493

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELA 179
            D G   +   L FPS+  ++EH+ + A
Sbjct: 494 NDLGQCRVQ-HLWFPSITEMLEHFRQHA 520


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 47.0 bits (110), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 8/86 (9%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           GW +  L+R  AE LLL  G   G++L+R+S    G YSLSVR       D ++H+ ++ 
Sbjct: 34  GWYHGNLTRHAAEALLLSNG-CDGSYLLRDSNETTGLYSLSVRAK-----DSVKHFHVEY 87

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE 177
              G+ +      F SL   V+H++ 
Sbjct: 88  --TGYSFKFGFNEFSSLKDFVKHFAN 111


>UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=Q9N3S5_CAEEL
          Length = 618

 Score = 47.0 bits (110), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 42/146 (28%), Positives = 67/146 (45%), Gaps = 7/146 (4%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEVSGREYHMPSVYV--AKVAHGW 93
           +    F A     +S+  G+ L +I +   +WW V S+    +  +P  +V  A+    W
Sbjct: 144 IVENRFLAQTPKEMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSHVVYAEYREPW 203

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
               +S   AE+ ++ P  P G+FLIRE+ ++   + L VR S   S      YR    +
Sbjct: 204 FAGNISSILAEQRVMQPQLPIGSFLIREN-SKTDTFVLVVRSSHNESPQAYIIYRRPNQE 262

Query: 154 NGWLYISPR---LTFPSLHALVEHYS 176
              +  + R   + F SLH LV HYS
Sbjct: 263 GFEIRDNHRPAVIHFGSLHQLVNHYS 288


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score = 46.6 bits (109), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 18/125 (14%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSV-YVAKVAHGWLYEGLSREKAEELLLLPG 111
           ++ E L I +E  D + +  +     +H     YV K+         +R +AEE+L   G
Sbjct: 590 KINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKI---------NRTQAEEML--SG 638

Query: 112 NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHAL 171
              G FLIRES ++RGCY+ SV +         +H  I R   G+ +  P   + SL  L
Sbjct: 639 KRDGTFLIRES-SQRGCYACSVVVD-----GDTKHCVIYRTATGFGFAEPYNLYGSLKEL 692

Query: 172 VEHYS 176
           V HY 
Sbjct: 693 VLHYQ 697


>UniRef50_A9UQX3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQX3_MONBE
          Length = 1160

 Score = 46.6 bits (109), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 30/98 (30%), Positives = 55/98 (56%), Gaps = 11/98 (11%)

Query: 88  KVAHGWLYEGL-SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD-RIR 145
           +VA    + GL  +   E+ L+ PG   G+F++R S +    +++ VR      W   ++
Sbjct: 4   EVADEEWFAGLQDKHSIEQRLMQPGVADGSFVLRSSASDPNAFTMVVR------WQGALK 57

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC 183
           ++RI + +  W ++SP + +PSL ALV  ++ +ADGI 
Sbjct: 58  NFRIFQQNYLW-HVSPTIGYPSLGALV--HTHIADGIA 92


>UniRef50_A9V1L3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V1L3_MONBE
          Length = 970

 Score = 46.6 bits (109), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 11/124 (8%)

Query: 69  TVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC 128
           TV++ VS  +    ++ +A+V + +L + L RE++E +L       G FLIRES+TR G 
Sbjct: 824 TVEASVSNMDPE--ALDMARVQY-FLTQELGRERSELMLNHGKVADGMFLIRESKTRAGT 880

Query: 129 YSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD--GICCPL 186
           Y L++     A    I H+ I+R     L  +    F     LV H+ +  D  G+ C L
Sbjct: 881 YVLTM-----AHAGTIHHFPIERTPTNRLKTNNGHQFADWEELV-HFFKTKDREGLPCRL 934

Query: 187 REPC 190
            + C
Sbjct: 935 TQAC 938


>UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_DROME
          Length = 723

 Score = 46.6 bits (109), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 26/84 (30%), Positives = 44/84 (52%), Gaps = 7/84 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  L+R +A  ++L     G G FL+R+S+TRRG + L+          R +H R+  
Sbjct: 442 WFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQ-----GRAKHLRLTI 496

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
            + G   +   L FPS+  ++EH+
Sbjct: 497 SEKGQCRVQ-HLWFPSIQEMLEHF 519


>UniRef50_A9V5F5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5F5_MONBE
          Length = 587

 Score = 46.6 bits (109), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 22/65 (33%), Positives = 42/65 (64%), Gaps = 7/65 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   GL RE A ELL +  +  GAF++R+SQ+++GCY+L+++     +   I+++ I+ +
Sbjct: 457 WYQAGLPREIAVELLAMSED--GAFIVRDSQSQKGCYALTMK-----AHGEIKNFIIKAI 509

Query: 153 DNGWL 157
             G++
Sbjct: 510 PEGYI 514


>UniRef50_P52735 Guanine nucleotide exchange factor VAV2 n=43 Tax=Euteleostomi
           RepID=VAV2_HUMAN
          Length = 878

 Score = 46.6 bits (109), Expect = 8e-04,   Method: Composition-based stats.
 Identities = 50/191 (26%), Positives = 85/191 (44%), Gaps = 40/191 (20%)

Query: 9   KTSSPS---PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
           K +SP+    S +GP  + V+MQ   H   A      P G+   L+ + G+ L ++  D 
Sbjct: 573 KFTSPADLDASGAGPGPKMVAMQ-NYHGNPA------PPGKPV-LTFQTGDVLELLRGDP 624

Query: 66  D--WWT---VQSE--------------VSGRE--YHMPSVYVAKVAHGWLYEGLSREKAE 104
           +  WW    VQ+               V GR      PS  +   A+ W    + R++ +
Sbjct: 625 ESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTD 684

Query: 105 ELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLT 164
            LL    +  G +LIRE       +++S++ +     D ++H ++   DN W++I+    
Sbjct: 685 NLL--KSHASGTYLIRERPAEAERFAISIKFN-----DEVKHIKVVEKDN-WIHITEAKK 736

Query: 165 FPSLHALVEHY 175
           F SL  LVE+Y
Sbjct: 737 FDSLLELVEYY 747


>UniRef50_C3YUH5 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YUH5_BRAFL
          Length = 302

 Score = 46.6 bits (109), Expect = 9e-04,   Method: Compositional matrix adjust.
 Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 1/62 (1%)

Query: 129 YSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
           Y++SV  S+  + +R+ H+++QR   G LY+   L F SL  L+EHY        C +  
Sbjct: 10  YTISVLHSKTGN-NRVNHFKVQRFTEGKLYVEAGLEFDSLTELLEHYLREGQIRSCTIST 68

Query: 189 PC 190
           PC
Sbjct: 69  PC 70


>UniRef50_C1BXS5 Tyrosine-protein kinase HCK n=1 Tax=Esox lucius RepID=C1BXS5_ESOLU
          Length = 142

 Score = 46.6 bits (109), Expect = 9e-04,   Method: Compositional matrix adjust.
 Identities = 24/86 (27%), Positives = 44/86 (51%), Gaps = 12/86 (13%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G+ +++  ++ PS +S G +              A+AL  +    +  L  + G+ L I+
Sbjct: 39  GNKANKTISTDPSVASDGSE------------TIAIALYDYEGINEGDLGFKKGDKLKIL 86

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVA 87
            E G+WW  +  V+G+E ++PS YVA
Sbjct: 87  QESGEWWRAKHAVTGQEGYIPSNYVA 112


>UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=Neoptera
           RepID=Q17DJ2_AEDAE
          Length = 564

 Score = 46.6 bits (109), Expect = 9e-04,   Method: Compositional matrix adjust.
 Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 7/86 (8%)

Query: 93  WLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  L+R +A +L+L  G +  G FL+R+S+TR+G + L+      A     +H R+  
Sbjct: 419 WFHGTLARSEAAQLVLHNGLSSHGVFLVRQSETRKGEFVLTFNFQGKA-----KHLRMTL 473

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE 177
            D G   +   L FPS+  ++EH+ +
Sbjct: 474 NDLGQCRVQ-HLWFPSITEMLEHFRQ 498


>UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194BDF4
          Length = 1106

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 38/102 (37%), Positives = 53/102 (51%), Gaps = 13/102 (12%)

Query: 85  YVAKVAHGWLYEGLS-REKAEELL----LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
           +  K  HG L  G   R+ AE+LL       G   G FL+RES+T  G Y+LS   S   
Sbjct: 383 FTEKWFHGKLGGGRDGRQIAEKLLHEYCTETGGKDGTFLVRESETFVGDYTLSFWRS--- 439

Query: 140 SWDRIRHYRIQ-RLDNGW--LYISPRLTFPSLHALVEHYSEL 178
              R++H RI  R + G    Y++  L F SL++L+ HY E+
Sbjct: 440 --SRVQHCRIHSRQEAGATKFYLTDNLVFDSLYSLICHYREV 479


>UniRef50_UPI000179134F PREDICTED: similar to signal transduction protein lnk-realted,
           partial n=1 Tax=Acyrthosiphon pisum RepID=UPI000179134F
          Length = 474

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 9/85 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLS-RPASWDRIRHYRIQ 150
           W +  L+R  A  L+   G  G G FL+R+S+TR+G Y L+     +P      +H R+ 
Sbjct: 297 WFHGMLARSDATNLVSHLGTNGHGMFLVRQSETRKGEYVLTFNFKGKP------KHLRMT 350

Query: 151 RLDNGWLYISPRLTFPSLHALVEHY 175
             D G   +   L+FPS+  ++EH+
Sbjct: 351 LNDQGHCRVQ-HLSFPSIQDMLEHF 374


>UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=SH2B1_HUMAN
          Length = 756

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 7/84 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  LSR KA +L+L  G    G FL+R+S+TRRG Y L+          + +H R+  
Sbjct: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ-----GKAKHLRLSL 581

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
            + G   +   L F S+  ++EH+
Sbjct: 582 NEEGQCRVQ-HLWFQSIFDMLEHF 604


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score = 46.2 bits (108), Expect = 0.001,   Method: Composition-based stats.
 Identities = 34/113 (30%), Positives = 55/113 (48%), Gaps = 13/113 (11%)

Query: 78  EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           E   P +        W +  LS ++AE+L+L  G   G+FL+RESQ++ G + LSVR   
Sbjct: 96  ELKQPLICAEPTTERWFHGNLSGKEAEKLILERGK-NGSFLVRESQSKPGDFVLSVRTD- 153

Query: 138 PASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
               D++ H  I+  D  +  +    +F +L  L++HY         P+ E C
Sbjct: 154 ----DKVTHVMIRWQDKKY-DVGGGESFGTLSELIDHYKR------NPMVETC 195


>UniRef50_Q8IZW8 Tensin-4 n=12 Tax=Eutheria RepID=TENS4_HUMAN
          Length = 715

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 40/134 (29%), Positives = 60/134 (44%), Gaps = 14/134 (10%)

Query: 68  WTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG 127
           +T   E   R+      +V   +  W    ++RE+A ELL       GAF+IR+S + RG
Sbjct: 424 FTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLR--KEEPGAFVIRDSSSYRG 481

Query: 128 CYSLSVRL--------SRPA--SWDRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHY 175
            + L++++        SRP   S D IRH+ I+    G           F SL A V  +
Sbjct: 482 SFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQH 541

Query: 176 SELADGICCPLREP 189
           S +A  + C L  P
Sbjct: 542 SIMALALPCKLTIP 555


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 17/101 (16%)

Query: 88  KVAHGWLYEGLS-REKAEELL----LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW- 141
           K  HG L  G   R  AE LL    +  G P G+FL+RES+T  G Y+LS        W 
Sbjct: 549 KWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSF-------WR 601

Query: 142 -DRIRHYRIQ-RLDNGW--LYISPRLTFPSLHALVEHYSEL 178
             +++H RI  R D G    +++  L F SL+ L+ HY ++
Sbjct: 602 NGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQV 642


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 30/83 (36%), Positives = 45/83 (54%), Gaps = 8/83 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W Y  ++R + + +L   G+ G  FLIR+S+T  G YS+S  L  P    R +H+R+   
Sbjct: 448 WYYGAITRSQCDTVLNGHGHDGD-FLIRDSETNMGDYSVS--LKAPG---RNKHFRVHVE 501

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
            N  +Y   +  F SL  LV+HY
Sbjct: 502 QN--MYCIGQRKFHSLDQLVDHY 522


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 35/113 (30%), Positives = 57/113 (50%), Gaps = 17/113 (15%)

Query: 91   HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             GW +  +SR  AE++L   G   G+FL+R S++ R  YSL+++     S     H RIQ
Sbjct: 978  QGWYHGSISRIDAEKILRPLGE--GSFLVRNSESTRQDYSLTLK-----SAKGFMHMRIQ 1030

Query: 151  RLDNGWLYISPRLT--FPSLHALVEHYS------ELADGICCPLREPCVLQKL 195
            R  +   YI  + +  FP++  ++ H+         A+ +C  L EP + Q L
Sbjct: 1031 RDPDSSQYILGQFSRPFPTIPDMIRHFCLNRLPVRGAEHMC--LLEPVIAQIL 1081


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score = 45.8 bits (107), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 40/153 (26%), Positives = 67/153 (43%), Gaps = 23/153 (15%)

Query: 92  GWLYEGLSREKAEELLL-LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
            W +  +SR+ AE +LL       G FL+RES +  G Y L V  +     + + HY+I+
Sbjct: 11  NWYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQN-----NEVVHYQIR 65

Query: 151 RL-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
           R  ++ +  I  +     L  L+EHY        C + +P +  +L     KD PP  T 
Sbjct: 66  RHGEDAFFSIDEQNIMHGLETLIEHY--------CKVNDPSLGVQLSKPIVKDPPPHDT- 116

Query: 210 PTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
                  ++  R+ L   A       +++E L+
Sbjct: 117 -------RRHGRTNLLHRAITQANCKVVTELLK 142


>UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa RepID=O77440_HYDAT
          Length = 624

 Score = 45.8 bits (107), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 37/136 (27%), Positives = 64/136 (47%), Gaps = 14/136 (10%)

Query: 59  TIISEDGDWWTVQSEVSGREYHMPSVYVA-KVAHG---WLYEGLSREKAEELLLLPGNPG 114
           T++  +G    V +E + R++ +   YV   + H    W +  + R +AE  L    +  
Sbjct: 127 TVLRTEG----VVNEEAVRKFKVKMEYVVGNILHRQQPWFHGVIPRTEAERRLK-SLSET 181

Query: 115 GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEH 174
           G FLIRE  + RG Y + +          + HY  +  + G L I    +F +L A+V  
Sbjct: 182 GMFLIRERGSPRGSYVIGLFYQ-----GGVYHYLFESNNQGQLSIKSGRSFDNLMAVVNF 236

Query: 175 YSELADGICCPLREPC 190
           YS+ ++G+ C L+  C
Sbjct: 237 YSQKSEGLFCTLKRAC 252



 Score = 44.3 bits (103), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 6/99 (6%)

Query: 93  WLYEGLSREKAEELLLLPGN-PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  ++R+ AE  L    +   G +L+RES +  G Y LSV   +     ++ HY IQR
Sbjct: 9   WFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSVCKDK-----KVIHYAIQR 63

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
             +G + I+    FP    LV H+     G+   L  PC
Sbjct: 64  QPSGMVGIADGPQFPGPVELVNHHKTSLGGLMTKLTYPC 102


>UniRef50_Q4T639 Chromosome undetermined SCAF8942, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4T639_TETNG
          Length = 431

 Score = 45.8 bits (107), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 33/83 (39%), Positives = 43/83 (51%), Gaps = 7/83 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W    L R +AEELLL  G P G+FL+RES +R+GCY+ SV +    +  R         
Sbjct: 330 WFVGDLKRGEAEELLL--GRPDGSFLVRES-SRKGCYACSVVVEGVVTALRG----AADA 382

Query: 153 DNGWLYISPRLTFPSLHALVEHY 175
           D G+ +  P     SL  LV HY
Sbjct: 383 DGGFGFAEPFDRHASLKELVLHY 405


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 13/152 (8%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR--IRHYR 148
           + W    +SR ++E+LL   G  G AF++R S ++ G Y++S+  S+  +  +  ++HY 
Sbjct: 294 YDWFAGNISRSQSEQLLRQKGKEG-AFMVRNS-SQVGMYTVSL-FSKAVNDKKGTVKHYH 350

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           +       LY++    F S+  L+ ++   + G+   LR         P+  K    P +
Sbjct: 351 VHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRH--------PVSTKANKVPDS 402

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           V   +  W+     +  L+   SG+  ++  G
Sbjct: 403 VSLGNGIWELKREEITLLKELGSGQFGVVQLG 434


>UniRef50_A9V2D7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2D7_MONBE
          Length = 811

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 10/90 (11%)

Query: 93  WLYEGLSREKAEEL---LLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           W   G+ R +  ++   +L  G PG  FLIR+ ++   CY +SVR ++    +++ +Y I
Sbjct: 49  WFVSGMPRTEVRQMAMDMLKKGRPGN-FLIRDVKSEPNCYGMSVRTTQ----NKLVNYLI 103

Query: 150 QRLDN--GWLYISPRLTFPSLHALVEHYSE 177
           ++     G+     + TFP++  LVE Y++
Sbjct: 104 EKRAQPPGFCIRGTKRTFPTVAKLVEFYAQ 133


>UniRef50_B3SCQ7 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3SCQ7_TRIAD
          Length = 700

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 6/95 (6%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           +    H W  E +++  A  ++ L   P G F++R+S TR  C ++SV+++   +   I 
Sbjct: 533 IEDTRHLWYQEDMTKVNA--IVFLQDQPIGTFVVRKS-TRHHCEAISVKVTVDGN---IG 586

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           H+  +   N W        F SL  L+ HY+   D
Sbjct: 587 HFLFKNNSNEWSIADFERKFVSLEDLLTHYTNNKD 621


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/97 (26%), Positives = 54/97 (55%), Gaps = 5/97 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           + +  ++RE++E  L   G+  G +L+R+S++  G Y+LS+   R     +  HY I+R 
Sbjct: 10  YFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGR-----QFYHYTIERE 64

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            N    I+   +  +   ++ ++S+ +DG+ C L++P
Sbjct: 65  LNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKP 101


>UniRef50_A8PYV3 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PYV3_BRUMA
          Length = 288

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 36/104 (34%), Positives = 54/104 (51%), Gaps = 8/104 (7%)

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ--R 151
            Y  + RE+A  LL    +  G FLIR+S T  G Y+LSVR    +   ++RHY I+   
Sbjct: 16  FYFHVGREEATRLLCQSDSDLGTFLIRDSTT-PGSYALSVR-EELSGDQQVRHYLIEPVE 73

Query: 152 LDNGWLYIS-PRLTFPSLHALVEHYSE--LAD-GICCPLREPCV 191
            DNG + +      F  + AL+ H+    LA+  + CPLR+  +
Sbjct: 74  ADNGKMNVKIADQYFVDIPALLNHFKMRILANVSLVCPLRKTAI 117


>UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tetraodontidae
           RepID=UPI00016E9A01
          Length = 580

 Score = 45.1 bits (105), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 12/101 (11%)

Query: 81  MPSVYVAKVAHG-----WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVR 134
           MP   V K  H      W +  +SR KA  L+   G  G G FL+R+S+TRRG Y L+  
Sbjct: 349 MPEQVVQKTDHFLFSYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVLTFN 408

Query: 135 LSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
                   + +H R+   + G   +   L FPS+  ++ H+
Sbjct: 409 YQ-----GKAKHLRLSLTEWGQCRVQ-HLRFPSVMDMLSHF 443


>UniRef50_B7Q548 Phosphoinositide-3-kinase, regulatory subunit, putative n=1
           Tax=Ixodes scapularis RepID=B7Q548_IXOSC
          Length = 427

 Score = 45.1 bits (105), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 8/84 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W  +   R++A+ LL   G   G FL+R S+   G Y+LS+      +  ++ H  IQ+ 
Sbjct: 318 WFVQDCDRKEAQRLL--EGRRDGTFLVRPSKMP-GQYALSI-----VAEGKVNHCLIQKT 369

Query: 153 DNGWLYISPRLTFPSLHALVEHYS 176
           D G+ +  P    P+L +LV HY+
Sbjct: 370 DRGYGFAEPYNIHPTLRSLVHHYA 393


>UniRef50_A9V6N4 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V6N4_MONBE
          Length = 1698

 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 32/100 (32%), Positives = 48/100 (48%), Gaps = 9/100 (9%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           A  WLY  L RE+AE+LL+    P G F IR+  +    + LS      A   ++ H  +
Sbjct: 706 AEAWLYPDLDRERAEQLLV--NKPDGTFAIRDG-SEEAAWVLSY-----ACGGQVEHAHM 757

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELAD-GICCPLRE 188
             ++ G         F +L A V++YS  +  G+ CPL E
Sbjct: 758 DAVETGIGLRDHEARFQTLQAFVDYYSSSSQRGLRCPLGE 797


>UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS
          Length = 727

 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 38/109 (34%), Positives = 51/109 (46%), Gaps = 16/109 (14%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP--ASWDRIRHY 147
           A  W    LSRE A  + LL     G FL+R+S T +  Y L VR+++P   S + +RH+
Sbjct: 463 AKFWYKANLSREDA--IALLASAQPGTFLVRDSTTYKNAYGLVVRVAQPPAGSQELVRHF 520

Query: 148 RIQRLDNGWLYISPRL-------TFPSLHALVEHYSELADGICCPLREP 189
            I+    G      RL        F SL ALV  +S     + C LR P
Sbjct: 521 LIEPTREGV-----RLKGCDNEPVFTSLSALVFEHSINRLALPCLLRLP 564


>UniRef50_UPI000069FBD6 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=2 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD6
          Length = 1664

 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 30/134 (22%)

Query: 85   YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP------ 138
            +V   +  W    +SRE+A  + +L G   G+FLIR+S + RG Y L+++++ P      
Sbjct: 1385 FVQDSSKFWYKPTISREQA--IAILRGAEPGSFLIRDSNSFRGAYGLALKVASPPPNVAA 1442

Query: 139  ------ASWDRIRHYRIQRLDNGWLY----ISPRLTFPSLHALVEHYSELADGICCPLRE 188
                  ++   +RH+ I+    G       I P   F SL ALV  +S        PL  
Sbjct: 1443 QPYKGDSTEQLVRHFLIETGPKGVKIKGSPIEPH--FGSLSALVSQHS------VTPLSL 1494

Query: 189  PCVLQKLGPLPGKD 202
            PC LQ    +P +D
Sbjct: 1495 PCRLQ----IPSRD 1504


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 26/86 (30%), Positives = 43/86 (50%), Gaps = 7/86 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  L R +A  L+L  G  G G FL+R+S+TR G + L+          R +H R+  
Sbjct: 322 WFHGTLGRSEATNLVLHDGARGHGLFLVRQSETRTGEFVLTFNFQ-----GRAKHLRMTI 376

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSE 177
            D G   +     F S++ ++EH+ +
Sbjct: 377 NDQGQCRVQ-HFWFQSIYEMLEHFRQ 401


>UniRef50_B4JBG9 GH11549 n=1 Tax=Drosophila grimshawi RepID=B4JBG9_DROGR
          Length = 325

 Score = 44.7 bits (104), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 43/143 (30%), Positives = 60/143 (41%), Gaps = 22/143 (15%)

Query: 56  EPLTIISEDG-DWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPG 114
           E L +I E G D W    E +  + H            W  +   R  A ELL   G P 
Sbjct: 99  EDLNVILEVGFDKWQHNFEKASNQPHRDESL-------WFIKDAKRHDAAELL--KGAPT 149

Query: 115 GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEH 174
           G FLIR      G Y+LS+     A    I H  I + ++G  + +P   +P+L  LVEH
Sbjct: 150 GTFLIRARDA--GHYALSI-----ACKGGIHHCIIFQTESGLGFAAPYNIYPTLKHLVEH 202

Query: 175 YS-----ELADGICCPLREPCVL 192
           Y+     E  D +   +R P + 
Sbjct: 203 YASNSLEEHNDTLTTVMRIPVLF 225


>UniRef50_A9V6N9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V6N9_MONBE
          Length = 1041

 Score = 44.3 bits (103), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 13/110 (11%)

Query: 70  VQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
            ++  S R    PS    K A  WL   +   KA  L ++ G P GAF++R S++R  CY
Sbjct: 745 ARANASFRGLQDPSTLTEKPA--WLQTNMP--KAAALQVIAGKPDGAFVVRSSESRTDCY 800

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNG----WLYISPRLTFPSLHALVEHY 175
            LS          ++ H  ++ + +     +L  +P  TF SL  L+E +
Sbjct: 801 VLSYMFR-----GQVHHELVRMVGDDQKVFFLNNAPHHTFQSLQNLIEFF 845


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score = 44.3 bits (103), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 23/57 (40%), Positives = 36/57 (63%), Gaps = 6/57 (10%)

Query: 78  EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
           E+ +PS  V   +H W + G+SREKAE+L+       G FL+R+S ++ G + L+VR
Sbjct: 113 EFKLPSEDVR--SHAWFHGGISREKAEKLI----RENGDFLVRDSISKPGNFVLTVR 163


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 44.3 bits (103), Expect = 0.004,   Method: Composition-based stats.
 Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 11/114 (9%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           HG L  G  R  AE+LL    +  GAFL+RES T  G YSLS    R   ++  R +   
Sbjct: 546 HGKLAGG--RVAAEKLLTDYKDVNGAFLVRESTTFTGDYSLS--FVRDGKYNHCRIHTKS 601

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG-PLPGKDT 203
                  Y+  +  F S++ L+ HY         PL+ P   Q L  P+P +++
Sbjct: 602 EGGKTRFYLIDQTLFDSIYELIMHYKS------NPLKSPTFEQVLAEPVPQQNS 649



 Score = 40.4 bits (93), Expect = 0.066,   Method: Composition-based stats.
 Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 11/93 (11%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR--ESQTRRG--CYSLSVRLSRPASWD 142
           + +   W +E LSR +AEE +L      GAFLIR  E  T+ G   Y++S R        
Sbjct: 649 SHLGKAWFHENLSRSEAEE-MLKKVRMDGAFLIRPSEQNTKAGQKNYAISFRAE-----G 702

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           +++H RI+ +D    Y      F SL  LV++Y
Sbjct: 703 KVKHCRIE-VDESGQYCIGSAIFDSLTELVQYY 734


>UniRef50_A7UTR8 AGAP005583-PA n=2 Tax=Anopheles gambiae RepID=A7UTR8_ANOGA
          Length = 915

 Score = 43.9 bits (102), Expect = 0.005,   Method: Composition-based stats.
 Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 9/84 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           WL E  SR+ AE+ L     P G FLIR      G Y+LS+     A   R+ H  I + 
Sbjct: 770 WLRERYSRQDAEKKL--ANKPTGTFLIRARNA--GHYALSI-----ACDGRVNHCIIHQT 820

Query: 153 DNGWLYISPRLTFPSLHALVEHYS 176
           + G+ +  P   + SL +LV HY+
Sbjct: 821 ERGYGFAEPYYIYDSLKSLVVHYA 844


>UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9A03
          Length = 489

 Score = 43.9 bits (102), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 7/104 (6%)

Query: 73  EVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSL 131
           +VS       S  ++  A+ W +  +SR KA  L+   G  G G FL+R+S+TRRG Y L
Sbjct: 361 DVSAPSSQRGSTELSSQAYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVL 420

Query: 132 SVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           +      A     +H R+   + G   +   L FPS+  ++ H+
Sbjct: 421 TFNYQGKA-----KHLRLSLTEWGQCRVQ-HLRFPSVMDMLSHF 458


>UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (Fragment) n=1
           Tax=Ixodes scapularis RepID=B7P7A9_IXOSC
          Length = 358

 Score = 43.9 bits (102), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 30/87 (34%), Positives = 43/87 (49%), Gaps = 9/87 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W Y G+SRE+A +LLL  G   G FL+R+S ++ G + LS      A    + H +I  +
Sbjct: 242 WFYSGMSREEATQLLLRHGTVDGVFLVRQSLSKPGTFVLSY-----AFRGTVHHVQIISV 296

Query: 153 DNG----WLYISPRLTFPSLHALVEHY 175
           +      +   S R  F  L  LVE Y
Sbjct: 297 EEKDQLCYSLDSGRTKFYDLLQLVEFY 323


>UniRef50_UPI000069FBD8 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=1 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD8
          Length = 1393

 Score = 43.9 bits (102), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 30/134 (22%)

Query: 85   YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP------ 138
            +V   +  W    +SRE+A  + +L G   G+FLIR+S + RG Y L+++++ P      
Sbjct: 1115 FVQDSSKFWYKPTISREQA--IAILRGAEPGSFLIRDSNSFRGAYGLALKVASPPPNVAA 1172

Query: 139  ------ASWDRIRHYRIQRLDNGWLY----ISPRLTFPSLHALVEHYSELADGICCPLRE 188
                  ++   +RH+ I+    G       I P   F SL ALV  +S        PL  
Sbjct: 1173 QPYKGDSTEQLVRHFLIETGPKGVKIKGSPIEPH--FGSLSALVSQHS------VTPLSL 1224

Query: 189  PCVLQKLGPLPGKD 202
            PC LQ    +P +D
Sbjct: 1225 PCRLQ----IPSRD 1234


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score = 43.9 bits (102), Expect = 0.006,   Method: Composition-based stats.
 Identities = 29/89 (32%), Positives = 44/89 (49%), Gaps = 8/89 (8%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           A  W +  + R++A++LL       G+F++RES T  G  +LS          R+ H RI
Sbjct: 565 AEKWYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCTLSFMYH-----GRVTHCRI 619

Query: 150 QRLDNG---WLYISPRLTFPSLHALVEHY 175
               N    + Y+   L F SL++LV HY
Sbjct: 620 HSQQNNGHTYFYLVHALLFDSLYSLVWHY 648


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score = 43.9 bits (102), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 9/87 (10%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
            GW +  ++R +AE +L +     G+FL+R S++ +  YSLS++ +R        H RIQ
Sbjct: 795 QGWFHGAITRVEAENVLRMLRE--GSFLVRNSESTKQDYSLSLKSARG-----FMHMRIQ 847

Query: 151 RLDNGWLYISPRLT--FPSLHALVEHY 175
           +  N   YI  + +  F S+  ++ H+
Sbjct: 848 KDGNDECYILGQFSKPFHSIPEMIRHF 874


>UniRef50_Q17M69 Rab gdp/gtp exchange factor n=3 Tax=Culicidae RepID=Q17M69_AEDAE
          Length = 1563

 Score = 43.5 bits (101), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 12/113 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ R  A  + LL G   G F++R S ++    ++SVRL    +   I HY IQ  
Sbjct: 248 WFLPGIQRSGA--VHLLQGKEEGNFIVRGS-SQSKTMAVSVRLPL-ETGPYIEHYLIQS- 302

Query: 153 DNGWLYI-SPRLTFPSLHALVEHYSELAD----GICCP--LREPCVLQKLGPL 198
           + G L + S R  F S+ AL+ HYS+  D     +C P  LRE    Q+L  L
Sbjct: 303 NEGLLSLESSRFKFDSIPALIAHYSQCCDELPVQLCLPKALREAKNRQQLSSL 355


>UniRef50_Q9HBL0 Tensin-1 n=79 Tax=Eumetazoa RepID=TENS1_HUMAN
          Length = 1735

 Score = 43.5 bits (101), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 22/122 (18%)

Query: 85   YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP------ 138
            +V   +  W    +SRE+A  + LL     GAF+IR+S + RG Y L++++S P      
Sbjct: 1455 FVQDTSKYWYKPEISREQA--IALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQ 1512

Query: 139  ------ASWDRIRHYRIQRLDNGW-LYISPRL-TFPSLHALVEHYSELADGICCPLREPC 190
                   + + +RH+ I+    G  L   P    F SL ALV  +S        PL  PC
Sbjct: 1513 QNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHS------IIPLALPC 1566

Query: 191  VL 192
             L
Sbjct: 1567 KL 1568


>UniRef50_B7QCJ2 Growth factor receptor-bound protein, putative n=1 Tax=Ixodes
           scapularis RepID=B7QCJ2_IXOSC
          Length = 203

 Score = 43.5 bits (101), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 31/87 (35%), Positives = 37/87 (42%), Gaps = 6/87 (6%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           A  W +  L RE A  LLL      GAFL+R S TR   + L            +RH +I
Sbjct: 98  AQPWFHGSLQRETATLLLLKHATEDGAFLVRRSLTRLDTFVLCYLFH-----GEVRHVQI 152

Query: 150 QRLDNGWLYI-SPRLTFPSLHALVEHY 175
           Q L      I S R  F  L  LV+ Y
Sbjct: 153 QTLGEDCFSIDSGRTKFSCLQQLVQFY 179


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score = 43.5 bits (101), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 27/84 (32%), Positives = 43/84 (51%), Gaps = 7/84 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SR KA  L+   G  G G FL+R+S+TRRG Y L+          + +H R+  
Sbjct: 410 WFHGPISRVKAAHLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQ-----GKAKHLRLSL 464

Query: 152 LDNGWLYISPRLTFPSLHALVEHY 175
            + G   +   L FPS+  ++ H+
Sbjct: 465 TEWGQCRVQ-HLRFPSVMDMLSHF 487


>UniRef50_UPI000194DBC6 PREDICTED: similar to tensin 4 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DBC6
          Length = 731

 Score = 43.1 bits (100), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 44/160 (27%), Positives = 70/160 (43%), Gaps = 28/160 (17%)

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL--------S 136
           +V   +  W    +SR++A +LL       G FL+R+S + RG + L++++        +
Sbjct: 462 FVMDTSKYWFKPSISRDRAIQLLR--DKEPGTFLVRDSTSFRGSFGLAMKVPGSPSGSQT 519

Query: 137 RPASWDRIRHYRIQRLDNG--WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
              S D +RH+ I+    G      S  L F SL A V  +S        PL  PC L  
Sbjct: 520 GEESSDLVRHFLIESSTKGVHLXGASEELYFGSLSAFVYQHS------ITPLALPCKLS- 572

Query: 195 LGPLP------GKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
              +P      G+D+P     P  SL  K    ++L+L +
Sbjct: 573 ---IPTRDLADGEDSPDCTPEPALSLARKTAVCNVLYLNS 609


>UniRef50_A4F2N7 Mt-tensin-b (Fragment) n=2 Tax=Molgula tectiformis RepID=A4F2N7_9ASCI
          Length = 1177

 Score = 43.1 bits (100), Expect = 0.008,   Method: Composition-based stats.
 Identities = 42/144 (29%), Positives = 67/144 (46%), Gaps = 27/144 (18%)

Query: 82   PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
            P ++V  V + W    ++RE+A  L +L   P G+F++R+S+   G Y L++++ +  S 
Sbjct: 887  PPLFVHDVQNLWYKPDITREQA--LDMLRHRPAGSFVVRDSRCFPGAYGLALKVDKLPSN 944

Query: 142  DR-----------IRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHYSELADGICCPLRE 188
             R           +RH+ I+    G           F SL ALV  +S        PL  
Sbjct: 945  VRPQAGADIQNELVRHFLIEPSSRGVKLKGCKNEPVFGSLPALVYQHS------ITPLAL 998

Query: 189  PC--VLQKLGPLPGKDTPPPVTVP 210
            PC  ++ K+ P     TPPP T+P
Sbjct: 999  PCRLIIPKIDPA----TPPPGTLP 1018


>UniRef50_B7P3R5 Suppressor of cytokine signaling-2, putative (Fragment) n=1
           Tax=Ixodes scapularis RepID=B7P3R5_IXOSC
          Length = 171

 Score = 43.1 bits (100), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 43/112 (38%), Positives = 56/112 (50%), Gaps = 8/112 (7%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI-- 149
           G+ YEGLS ++A+ LL       G FL+R+S   R  ++LSV+  R  +  RI HYR   
Sbjct: 29  GYYYEGLSWQEADRLL--RDRAVGTFLVRDSSDNRFLFALSVQTERGPTSARI-HYRKGQ 85

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSEL---ADGICCPLREPCVLQKLGPL 198
            RLD+     S    F  +  LVEHY +L   A G     RE   LQ L  L
Sbjct: 86  FRLDSEDALSSCMPWFSCVVRLVEHYVQLSRSAKGQMPLYRELLPLQHLCRL 137


>UniRef50_UPI000069FBD7 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=1 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD7
          Length = 1410

 Score = 43.1 bits (100), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 40/135 (29%), Positives = 62/135 (45%), Gaps = 31/135 (22%)

Query: 85   YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP------ 138
            +V   +  W    +SRE+A  + +L G   G+FLIR+S + RG Y L+++++ P      
Sbjct: 1130 FVQDSSKFWYKPTISREQA--IAILRGAEPGSFLIRDSNSFRGAYGLALKVASPPPNVAA 1187

Query: 139  -------ASWDRIRHYRIQRLDNGWLY----ISPRLTFPSLHALVEHYSELADGICCPLR 187
                   ++   +RH+ I+    G       I P   F SL ALV  +S        PL 
Sbjct: 1188 QPYKAGDSTEQLVRHFLIETGPKGVKIKGSPIEPH--FGSLSALVSQHS------VTPLS 1239

Query: 188  EPCVLQKLGPLPGKD 202
             PC LQ    +P +D
Sbjct: 1240 LPCRLQ----IPSRD 1250


>UniRef50_C3YCZ8 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YCZ8_BRAFL
          Length = 496

 Score = 43.1 bits (100), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 32/88 (36%), Positives = 46/88 (52%), Gaps = 9/88 (10%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
           V HGW +  +SR +AEE L    N  G+FL+R+S   R   SLS R     S+DR  H R
Sbjct: 341 VRHGWYWGPISRAEAEEKLAHLSN--GSFLVRDSSDDRYLLSLSFR-----SYDRTFHTR 393

Query: 149 IQRLDNGWLYISPRLT--FPSLHALVEH 174
           I+  +  + + S   +    S+  L+EH
Sbjct: 394 IEHCNGIFSFYSQVESEGHKSIVDLIEH 421


>UniRef50_Q8INY1 Suppressor of cytokine signaling at 36E, isoform B n=6
           Tax=melanogaster subgroup RepID=Q8INY1_DROME
          Length = 720

 Score = 43.1 bits (100), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 36/128 (28%), Positives = 59/128 (46%), Gaps = 16/128 (12%)

Query: 68  WTVQSEVSGREYHMPSVYVAKVAHGWLYEG-LSREKAEELLLLPGNPGGAFLIRESQTRR 126
            TV S++      +P +   K+ +   Y G + R +AE LL   G P G FL+R+S    
Sbjct: 450 MTVHSQIDFMHCLVPDL--EKITNSSFYWGKMDRYEAEHLL--EGKPEGTFLLRDSAQEE 505

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR---LTFPSLHALVEHYSELADGIC 183
             +S++ R      + R  H RI++  + + +        T P++  L+EHY    D  C
Sbjct: 506 FLFSVTFR-----KYGRSLHARIEQSGHKFSFDCHDPCVFTAPTVTGLLEHYK---DPAC 557

Query: 184 CPLREPCV 191
               EPC+
Sbjct: 558 VMFFEPCL 565


>UniRef50_B0ETU6 Proline-serine-threonine phosphatase interacting protein, putative
           n=2 Tax=Entamoeba RepID=B0ETU6_ENTDI
          Length = 374

 Score = 43.1 bits (100), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 19/64 (29%), Positives = 35/64 (54%), Gaps = 2/64 (3%)

Query: 24  PVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPS 83
           P++ QP+ +         + A E   LS++ G+ + ++S++GDWW    E++G+    PS
Sbjct: 311 PINQQPKTNNNMCRVNYDYSAQETNELSIKTGDIIKVLSKEGDWWI--GELNGQTGQFPS 368

Query: 84  VYVA 87
            YV 
Sbjct: 369 NYVT 372


>UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY34_ACYPI
          Length = 214

 Score = 43.1 bits (100), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 18/42 (42%), Positives = 28/42 (66%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
           W ++ +SR++A  +L   GN  G FLIRES+++ G Y LS +
Sbjct: 106 WYHKNMSRDQAANVLHALGNKDGVFLIRESKSKCGSYVLSFK 147


>UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S7K1_TRIAD
          Length = 864

 Score = 43.1 bits (100), Expect = 0.010,   Method: Composition-based stats.
 Identities = 37/130 (28%), Positives = 58/130 (44%), Gaps = 18/130 (13%)

Query: 95  YEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDN 154
           Y  +S E+AE+LL L  +  GAFLIR S    G ++LS+R        RI+ +  + +  
Sbjct: 8   YIDVSYEQAEDLLRLE-DQDGAFLIRPSHRVPGTFALSIRYRNKFFHHRIKVFHGRFVCE 66

Query: 155 GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSL 214
           G+       TF S+  LV+H+ +   G+  PL              K   PP        
Sbjct: 67  GF----TEKTFSSMDELVKHFRQPNQGLAHPLT-------------KSVSPPTPTEEDES 109

Query: 215 NWKKLDRSLL 224
           N++   ++LL
Sbjct: 110 NYENSLKTLL 119


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2...   314   2e-84
UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 ...   281   2e-74
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   276   7e-73
UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A...   272   7e-72
UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_...   259   5e-68
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   259   7e-68
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   249   8e-65
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   247   2e-64
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   242   1e-62
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   241   2e-62
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   239   6e-62
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   238   1e-61
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   233   3e-60
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   233   4e-60
UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q...   232   8e-60
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   231   1e-59
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   231   2e-59
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   229   5e-59
UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homini...   229   6e-59
UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun se...   224   2e-57
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   221   3e-56
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   220   3e-56
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   217   4e-55
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   214   2e-54
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   213   5e-54
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   212   9e-54
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...   211   1e-53
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   210   4e-53
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   209   6e-53
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   209   7e-53
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          208   1e-52
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   208   1e-52
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   208   2e-52
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   207   3e-52
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   206   5e-52
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          206   5e-52
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   206   6e-52
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   206   7e-52
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   206   7e-52
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...   204   3e-51
UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californic...   202   6e-51
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   202   1e-50
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   197   2e-49
UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tet...   197   4e-49
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   195   1e-48
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   195   1e-48
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   195   1e-48
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   193   4e-48
UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   193   5e-48
UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...   192   7e-48
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...   192   1e-47
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   192   1e-47
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   190   4e-47
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   189   7e-47
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   189   1e-46
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   187   2e-46
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   186   9e-46
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   184   3e-45
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   183   6e-45
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   182   7e-45
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   182   1e-44
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   181   2e-44
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   180   4e-44
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   180   4e-44
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   179   7e-44
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   179   7e-44
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   179   8e-44
UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun se...   179   9e-44
UniRef50_B7Z4J2 cDNA FLJ50391, highly similar to SRC-like-adapte...   179   1e-43
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...   177   3e-43
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...   176   5e-43
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   176   6e-43
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...   176   8e-43
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   175   1e-42
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     174   2e-42
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   171   2e-41
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   171   2e-41
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   164   3e-39
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   164   4e-39
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   163   7e-39
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   160   5e-38
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   157   3e-37
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   155   2e-36
UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n...   154   3e-36
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...   152   1e-35
UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative ...   152   1e-35
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...   150   5e-35
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...   149   8e-35
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   147   3e-34
UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n...   146   6e-34
UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE      146   8e-34
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...   145   1e-33
UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo sal...   145   1e-33
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...   145   1e-33
UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE    145   2e-33
UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicu...   144   3e-33
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   141   2e-32
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...   141   2e-32
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   140   3e-32
UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   139   1e-31
UniRef50_Q4T2Z8 Chromosome 18 SCAF10147, whole genome shotgun se...   138   1e-31
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI         138   2e-31
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   138   2e-31
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   137   3e-31
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   136   5e-31
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   136   8e-31
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...   135   1e-30
UniRef50_P78453 Tyrosine kinase (Fragment) n=11 Tax=Euteleostomi...   134   4e-30
UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Dan...   133   7e-30
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   133   7e-30
UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorh...   132   1e-29
UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes...   132   1e-29
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   131   2e-29
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...   130   5e-29
UniRef50_UPI00016E9C47 UPI00016E9C47 related cluster n=1 Tax=Tak...   129   7e-29
UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   129   9e-29
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   128   2e-28
UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound p...   125   1e-27
UniRef50_B1AH86 GRB2-related adaptor protein 2 (Fragment) n=3 Ta...   124   3e-27
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   124   3e-27
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   124   3e-27
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   121   3e-26
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...   120   3e-26
UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=...   119   1e-25
UniRef50_UPI000155BA92 PREDICTED: similar to Fyn-related kinase,...   118   2e-25
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...   117   5e-25
UniRef50_UPI0000D555ED PREDICTED: similar to CG33993 CG33993-PA ...   116   6e-25
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...   116   7e-25
UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostom...   116   7e-25
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...   116   8e-25
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   116   8e-25
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...   116   9e-25
UniRef50_UPI00015B5EF2 PREDICTED: similar to ENSANGP00000021630 ...   115   1e-24
UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n...   115   1e-24
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...   115   1e-24
UniRef50_UPI000186F028 conserved hypothetical protein n=1 Tax=Pe...   115   2e-24
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   114   3e-24
UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Tak...   114   4e-24
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   113   5e-24
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...   113   7e-24
UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi s...   112   1e-23
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   112   1e-23
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...   111   2e-23
UniRef50_B7QKA0 Putative uncharacterized protein n=1 Tax=Ixodes ...   111   2e-23
UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa ...   111   3e-23
UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepI...   111   3e-23
UniRef50_UPI000180B667 PREDICTED: similar to GF12762 n=1 Tax=Cio...   110   5e-23
UniRef50_A7URX1 AGAP006893-PA n=3 Tax=Culicidae RepID=A7URX1_ANOGA    110   6e-23
UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS         109   8e-23
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   109   1e-22
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...   108   1e-22
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...   108   1e-22
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...   108   1e-22
UniRef50_Q9VRS2 CG32406 n=13 Tax=Drosophila RepID=Q9VRS2_DROME        108   2e-22
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN         108   3e-22
UniRef50_Q7Q480 AGAP008273-PA (Fragment) n=3 Tax=Culicidae RepID...   107   3e-22
UniRef50_C4Q5Y9 Tensin-related n=1 Tax=Schistosoma mansoni RepID...   107   5e-22
UniRef50_P52735 Guanine nucleotide exchange factor VAV2 n=43 Tax...   107   5e-22
UniRef50_Q6NR09 CG33993 n=13 Tax=Diptera RepID=Q6NR09_DROME           106   7e-22
UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleos...   106   1e-21
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...   105   2e-21
UniRef50_A7T8K3 Predicted protein n=1 Tax=Nematostella vectensis...   105   2e-21
UniRef50_Q380D8 AGAP001259-PA (Fragment) n=3 Tax=Culicidae RepID...   105   2e-21
UniRef50_A7RU23 Predicted protein n=1 Tax=Nematostella vectensis...   104   4e-21
UniRef50_Q5BXE5 SJCHGC04002 protein (Fragment) n=1 Tax=Schistoso...   103   4e-21
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   103   6e-21
UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchi...   103   6e-21
UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichop...   103   6e-21
UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_S...   103   6e-21
UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluvia...   101   2e-20
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...   101   2e-20
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...   101   3e-20
UniRef50_P50745 SH2B adapter protein 3 n=2 Tax=Rattus norvegicus...   100   4e-20
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...    99   1e-19
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...    99   2e-19
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...    98   3e-19
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...    97   7e-19
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE         97   7e-19
UniRef50_Q8IZW8 Tensin-4 n=12 Tax=Eutheria RepID=TENS4_HUMAN           95   2e-18
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...    95   2e-18
UniRef50_B4JFU1 GH19392 (Fragment) n=6 Tax=cellular organisms Re...    94   4e-18
UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi Rep...    94   5e-18
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...    93   8e-18
UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE       93   1e-17
UniRef50_Q9VHC3 Blistery n=8 Tax=Sophophora RepID=Q9VHC3_DROME         92   1e-17
UniRef50_C3ZG97 Putative uncharacterized protein n=3 Tax=Chordat...    92   1e-17
UniRef50_A9V545 Predicted protein n=1 Tax=Monosiga brevicollis R...    92   2e-17
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    92   2e-17
UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=T...    91   5e-17
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    90   7e-17
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...    90   8e-17
UniRef50_A9V5H9 Predicted protein n=1 Tax=Monosiga brevicollis R...    90   9e-17
UniRef50_Q8MQW8 Protein sprint n=6 Tax=Drosophila RepID=SPRI_DROME     89   1e-16
UniRef50_A9V1L3 Predicted protein n=1 Tax=Monosiga brevicollis R...    89   2e-16
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...    88   2e-16

Sequences not found previously or not previously below threshold:

UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (...   141   3e-32
UniRef50_Q5BYR6 SJCHGC04559 protein (Fragment) n=1 Tax=Schistoso...   123   7e-27
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...   120   5e-26
UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2)...   119   1e-25
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   118   2e-25
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   116   7e-25
UniRef50_Q70W05 Src protein (Fragment) n=1 Tax=Ciona intestinali...   114   4e-24
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   112   2e-23
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME       111   2e-23
UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia t...   111   3e-23
UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine ki...   110   6e-23
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...   107   3e-22
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...   107   3e-22
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   107   4e-22
UniRef50_Q9UKW4 Guanine nucleotide exchange factor VAV3 n=112 Ta...   105   2e-21
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...   104   3e-21
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...   103   7e-21
UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=...   103   7e-21
UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=...   103   7e-21
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   102   1e-20
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...   101   3e-20
UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax...   100   3e-20
UniRef50_B1AT95 Growth factor receptor bound protein 2 (Fragment...   100   4e-20
UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene ...    99   2e-19
UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos...    98   2e-19
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...    98   2e-19
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...    96   2e-18
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...    95   2e-18
UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosph...    95   3e-18
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...    95   3e-18
UniRef50_UPI0000EB251F Tyrosine-protein kinase Tec (EC 2.7.10.2)...    94   3e-18
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...    94   4e-18
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...    94   6e-18
UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein act...    94   6e-18
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...    93   1e-17
UniRef50_B3S5N2 Putative uncharacterized protein n=1 Tax=Trichop...    92   1e-17
UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...    92   1e-17
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    92   2e-17
UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY3...    92   2e-17
UniRef50_UPI000194DBC6 PREDICTED: similar to tensin 4 n=1 Tax=Ta...    92   2e-17
UniRef50_P62993-2 Isoform GRB3-3 of Growth factor receptor-bound...    92   2e-17
UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun seq...    92   2e-17
UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (...    91   3e-17
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...    91   3e-17
UniRef50_A4F2N7 Mt-tensin-b (Fragment) n=2 Tax=Molgula tectiform...    91   4e-17
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...    91   5e-17
UniRef50_C3Y8I0 Putative uncharacterized protein (Fragment) n=1 ...    90   9e-17
UniRef50_UPI000069FBD6 Tensin-like C1 domain-containing phosphat...    89   1e-16
UniRef50_Q95ZL4 Temporarily assigned gene name protein 163, isof...    89   1e-16
UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome ...    89   1e-16
UniRef50_UPI000069FBD7 Tensin-like C1 domain-containing phosphat...    89   1e-16
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...    89   1e-16
UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS          89   2e-16
UniRef50_UPI000069FBD8 Tensin-like C1 domain-containing phosphat...    89   2e-16
UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...    89   2e-16

>UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2_HUMAN
          Length = 261

 Score =  314 bits (804), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 205/262 (78%), Positives = 221/262 (84%), Gaps = 4/262 (1%)

Query: 1   MGSLSSRGKTSSPSPSSSGPD-QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGSL SR K+      SS    Q PV+M+ ER K TAVALGSFPAG  A LSLRLGEPLT
Sbjct: 1   MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+SEDGDWWTV SEVSGREY++PSV+VAKV+HGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61  IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RESQTRRG YSLSVRLSRPASWDRIRHYRI  LDNGWLYISPRLTFPSL ALV+HYSELA
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA 180

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           D ICC L+EPCVLQ+ GPLPGKD P PVTV  + LNWK+LD SLLF EA A+GE SLLSE
Sbjct: 181 DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEA-ATGEESLLSE 239

Query: 240 GLRESLSSYISLAEDP--LDDA 259
           GLRESLS YISL ++   LDDA
Sbjct: 240 GLRESLSFYISLNDEAVSLDDA 261


>UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 n=1 Tax=Monodelphis
           domestica RepID=UPI0000F2B3BE
          Length = 310

 Score =  281 bits (718), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 146/232 (62%), Positives = 181/232 (78%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYV 86
            +    K  AVAL SFPAGEQ  L LRLGEPL IIS++G+WW V SE + +EY +PS +V
Sbjct: 68  QRARVSKDMAVALDSFPAGEQGELVLRLGEPLIIISDNGEWWRVLSEATSKEYVVPSSHV 127

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
           A+++ GWLYEGL+REKAE+LLLLP N GG+FLIRESQTRRG YSLSVRLSRP S D +RH
Sbjct: 128 ARISQGWLYEGLNREKAEDLLLLPSNHGGSFLIRESQTRRGAYSLSVRLSRPTSRDVVRH 187

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPP 206
           YRI RL+NGW YISPRLTFPSL ALVEHY+E+AD +C  L EPC  +++G LPG++ PPP
Sbjct: 188 YRIHRLENGWFYISPRLTFPSLQALVEHYTEMADDLCSLLVEPCAFRRVGLLPGRNIPPP 247

Query: 207 VTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
           V+V   +LNWK++D SLLF E  +SG+   +S GLRE++ +YIS+ EDP  D
Sbjct: 248 VSVQRPTLNWKEVDSSLLFSEVSSSGDTCPISVGLREAIGTYISMTEDPSLD 299


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  276 bits (705), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 118/256 (46%), Positives = 163/256 (63%), Gaps = 4/256 (1%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG++  +   S+   S +  +      Q    K   VAL +FP   Q  LS+  GE L I
Sbjct: 1   MGNIPCKKGYSAIEASLTNLEIN----QAAADKCIFVALYNFPLSGQTDLSIHFGEQLNI 56

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           +SEDGDW  V S  +G+E ++P+ YVAKV + WLY+G++REKAEELL++  N  G+FLIR
Sbjct: 57  LSEDGDWLKVSSASTGQECYLPTNYVAKVCNRWLYKGINREKAEELLMVNSNRSGSFLIR 116

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES+TR G Y+LS+R +   S D I+HYRI +LDNGW YI+PRLTF +L  +V++YSE+AD
Sbjct: 117 ESETRSGSYTLSIRKTNHTSRDSIKHYRIHQLDNGWFYIAPRLTFATLQDMVDYYSEVAD 176

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           GICC L EPCV+Q++     +    P+ V   +LNW KLD   LF +     E   LS G
Sbjct: 177 GICCTLTEPCVVQRVPNPVIQRPSEPIVVRKPTLNWTKLDSMDLFNKDDKLNEDCPLSLG 236

Query: 241 LRESLSSYISLAEDPL 256
           LRE++SSY+ + +D  
Sbjct: 237 LREAVSSYMLMTQDSE 252


>UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A9JR87_DANRE
          Length = 264

 Score =  272 bits (696), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 103/255 (40%), Positives = 157/255 (61%), Gaps = 3/255 (1%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           S   RG  +      +     P++M+  R+    V+L  +P+      ++R+GE L I+S
Sbjct: 6   SKDRRGPNAHAVLLDTEDSNGPLTMESIRY--VLVSLYDYPSRGPGDCAIRVGERLNILS 63

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
           ++G+W+ V S  +G E ++PS Y AK+ + W + GLS+ K+EELL+LP N  G+FLIRES
Sbjct: 64  DEGEWFKVSSSATGNESYIPSNYTAKLYNRWQFVGLSKRKSEELLMLPHNQPGSFLIRES 123

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
           +T  G Y+LSVR S       ++HYRI  +DNGW YISP LTF +L  ++ HYS ++DG+
Sbjct: 124 ETFPGNYTLSVRKSGSQERASVKHYRISCIDNGWFYISPGLTFRTLSDMIAHYS-VSDGL 182

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
           CC L EPC +     +P  +  PPV V   ++NWK +D S++F +     E SL+SEGL+
Sbjct: 183 CCTLGEPCFIIGSNNVPVVNGAPPVAVKRPTINWKDVDSSMIFSQTKEGAEDSLVSEGLK 242

Query: 243 ESLSSYISLAEDPLD 257
           E+++SY+ + E   D
Sbjct: 243 EAINSYLYMTEKCED 257


>UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_HUMAN
          Length = 276

 Score =  259 bits (663), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 103/242 (42%), Positives = 145/242 (59%), Gaps = 9/242 (3%)

Query: 16  SSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVS 75
           S+  P + P+             L  +P+ + +    R GE L +IS++G WW   S  +
Sbjct: 7   STPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLST 66

Query: 76  GREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
           GRE ++P + VA+V HGWL+EGL R+KAEELL LP    G+F+IRES+T++G YSLSVR 
Sbjct: 67  GRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH 126

Query: 136 SRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKL 195
                  +++HYRI RL N W YISPRLTF  L  LV HYSE+ADG+CC L  PC+ Q  
Sbjct: 127 R------QVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQST 180

Query: 196 GPLPGKDTPPPVTVPTSSLNWKKLDR---SLLFLEAPASGEASLLSEGLRESLSSYISLA 252
                + +  PVT+   +++W+++ R        E P   + SL S GLRES++SY+SL 
Sbjct: 181 AAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLT 240

Query: 253 ED 254
            +
Sbjct: 241 SE 242


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  259 bits (662), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 101/271 (37%), Positives = 138/271 (50%), Gaps = 36/271 (13%)

Query: 8   GKTSSPSPSSSG--PDQ-EPVSMQPER-----HKVTAVALGSFPAGEQARLSLRLGEPLT 59
           G    P PS +G  P+Q  PV   PE      +    VAL  + A     LS R GE L 
Sbjct: 32  GVPQIPMPSHAGQPPEQIRPVPQIPESETAGANAKIFVALYDYDARTDEDLSFRKGEHLE 91

Query: 60  IISE-DGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPG 114
           I+++  GDWW  +S+ +  E ++PS YVAK     A  W +  + R +AE+ LLLP N  
Sbjct: 92  ILNDTQGDWWLARSKKTRSEGYIPSNYVAKLKSIEAEPWYFRKIKRIEAEKKLLLPENEH 151

Query: 115 GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEH 174
           GAFLIR+S++R   YSLSVR       D ++HYRI++LD G  +I+ R TF +L  LVEH
Sbjct: 152 GAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEH 206

Query: 175 YSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS---LNWKKLDRSLLFLEAPAS 231
           YS+ +DG+C  L +PCV              PVT   S      W+    SL F+    S
Sbjct: 207 YSKDSDGLCVNLCKPCV----------QIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGS 256

Query: 232 GEASLLSEGLRE-----SLSSYISLAEDPLD 257
           G+   + EGL       ++ +  S   DP D
Sbjct: 257 GQFGDVWEGLWNNTTPVAIKTLKSGTMDPKD 287


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  249 bits (635), Expect = 8e-65,   Method: Composition-based stats.
 Identities = 80/216 (37%), Positives = 112/216 (51%), Gaps = 13/216 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV--- 89
              VAL  + A  +  LS   GE   I++  +GDWW  +S  +G   ++PS YVA V   
Sbjct: 85  TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            A  W +  L R+ AE  LL  GNP G FLIRES+T +G YSLS+R       D ++HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I++LDNG  YI+ R  F +L  LV+HYSE A G+CC L  PC         G      ++
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK-------GMPRLTDLS 257

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES 244
           V T  + W+    SL  ++   +G+   +  G    
Sbjct: 258 VKTKDV-WEIPRESLQLIKRLGNGQFGEVWMGTWNG 292


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  247 bits (631), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 86/241 (35%), Positives = 127/241 (52%), Gaps = 19/241 (7%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGD 66
           G  + P+  S+ P    V           VAL  + A     LS + GE L I+++  GD
Sbjct: 59  GGRNGPTIPSAVP--PEVETSAATGTKIFVALYDYDARTDEDLSFKKGEHLDILNDTQGD 116

Query: 67  WWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
           WW  +S+ + +E ++PS YVAK+    A  W +  + R +AE+ LLLP N  GAFL+R+S
Sbjct: 117 WWFARSKSTKQEGYIPSNYVAKLKSIEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDS 176

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
           ++RR  +SLSVR       D ++HYRI++LD G  +I+ R TF +L  LV+HY   ADG+
Sbjct: 177 ESRRNDFSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVDHYGNEADGL 231

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
           C  LR+PCV Q   P+            ++   W+    SL F+     G+   + EGL 
Sbjct: 232 CVNLRKPCV-QVEKPMTSG------LSHSTRDQWEIERSSLKFVRKLGQGQFGEVWEGLW 284

Query: 243 E 243
            
Sbjct: 285 N 285


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  242 bits (617), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 68/226 (30%), Positives = 112/226 (49%), Gaps = 20/226 (8%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEVSGREYH 80
             P S  P+      VA+ S+       L    G+ L II++D  +W+  +S  +G+  +
Sbjct: 44  SPPSSPLPDN---LVVAIYSYNPKHDGDLGFEKGDKLKIINKDDSEWYLAESLTTGQRGY 100

Query: 81  MPSVYVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           +P  ++A        W ++ +SR +A   L+ PGN  G+FL+RES+T  G YSLS+R   
Sbjct: 101 IPYNFIAMSTMETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFD 160

Query: 138 PASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGP 197
             + D ++HYRI+ +DNG  YI+ +++F SL  LV+HYS  +DG+C  L +PC  +    
Sbjct: 161 -NNGDGVKHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKLVKPCQSKAPQK 219

Query: 198 LPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
              +D             W+    SL       +G+   +  G+  
Sbjct: 220 PWWQD------------EWEIPRESLKLERKLGAGQFGEVWMGVYN 253


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 77/216 (35%), Positives = 106/216 (49%), Gaps = 16/216 (7%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAK---- 88
              VAL  + A     LS + GE   II+  +GDWW  +S  +G+  ++PS YVA     
Sbjct: 94  TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSI 153

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            A  W +  + R+ AE LLL PGN  G FL+RES+T +G YSLS+R       D ++HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I++LDNG  YI+ R  F +L  LV+HY+E ADG+C  L   C   K           P T
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVK-----------PQT 262

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES 244
              +   W+    SL        G    +  G    
Sbjct: 263 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG 298


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  239 bits (611), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 78/233 (33%), Positives = 115/233 (49%), Gaps = 21/233 (9%)

Query: 16  SSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEV 74
           S + P      M         VAL  + A     LS + GE L II+  DGDWW  +S +
Sbjct: 44  SHNQPPNINPPMLGGPGVTIFVALYDYEARISEDLSFKKGERLQIINTADGDWWYARSLI 103

Query: 75  SGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
           +  E ++PS YVA      A  W +  + R +AE+ L++ G P G FLIR+++T  G +S
Sbjct: 104 TNSEGYIPSTYVAPEKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFS 163

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           LSVR       D ++HYR+++LD G  +I+ R  F SL+ LV+HY++ ADG+ C L  PC
Sbjct: 164 LSVRD-----GDSVKHYRVRKLDTGGYFITTRAPFNSLYELVQHYTKDADGLVCALTLPC 218

Query: 191 VLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
              K           PVT   +   W+    SL       +G+   +  G+  
Sbjct: 219 PKDK-----------PVTGGIAKDAWEIPRESLRLNRKLGAGQFGEVWAGVWN 260


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 74/245 (30%), Positives = 120/245 (48%), Gaps = 17/245 (6%)

Query: 14  SPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSE 73
           +  ++G     V  + E  +   VAL  + A     L  + GE L II E G+WW  +S 
Sbjct: 44  TSQNAGLLPGQVFQKMEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKARSL 103

Query: 74  VSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
            + +E  +PS YVA+        W Y+ ++R+ AE  LL P N  G++LIRES+T +G Y
Sbjct: 104 TTRKEGFIPSNYVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSY 163

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           SLS+R       D ++HY+I+ LDNG  YISP++TF  + ++++HY + +DG+C  L + 
Sbjct: 164 SLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKA 223

Query: 190 CVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR-ESLSSY 248
           C   K      KD             W+    S+  ++   +G+   +       S    
Sbjct: 224 CEKPKAQKPWDKDA------------WEISKDSIKMVKKLGAGQFGEVWMAFYNNSTKVA 271

Query: 249 ISLAE 253
           +   +
Sbjct: 272 VKTLK 276


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  233 bits (595), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 88/260 (33%), Positives = 131/260 (50%), Gaps = 21/260 (8%)

Query: 3   SLSSRGKTSSPSPSS---SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
            +S++ K + P P     +     P     +  K   VAL  + A     L +  GE L 
Sbjct: 27  KVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQ 86

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGG 115
           ++   GDWW  +S V+GRE ++PS +VA+V       W +    R++AE  LL P N  G
Sbjct: 87  VLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAG 146

Query: 116 AFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           +FLIRES+T +G +SLSV+       + I+HY+I+ LD G  YISPR+TFPSL ALV+HY
Sbjct: 147 SFLIRESETNKGAFSLSVKD-VTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHY 205

Query: 176 SELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEAS 235
           S+  DG+C  L  PCV             P    P +   W+   +SL  +    SG+  
Sbjct: 206 SKKGDGLCQRLTLPCVR------------PAPQNPWAQDEWEIPRQSLRLVRKLGSGQFG 253

Query: 236 LLSEG-LRESLSSYISLAED 254
            +  G  + ++   I   ++
Sbjct: 254 EVWMGYYKNNMKVAIKTLKE 273


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  233 bits (594), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 73/225 (32%), Positives = 117/225 (52%), Gaps = 18/225 (8%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVS-GREYHMPSVYVAKV----A 90
           V    + +     LS + G+ + IIS ++GDWW  +S+ + G+E ++PS YVA+     A
Sbjct: 60  VGKYDYDSRTDDDLSFKKGDLMYIISTDEGDWWFARSKDTAGKEGYIPSNYVAEYKSLDA 119

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W    + R +AE++L    N  G+FLIR+S+T  G +SLSV+       DR+RHYR++
Sbjct: 120 EEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQ-----DRVRHYRVR 174

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
           RL++G L+++ R TF  LH LV+HY    DG+CC L  PC+  +     G        + 
Sbjct: 175 RLEDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQAEKPQTAG-------LLR 227

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDP 255
            ++  W+     +  L    +G+   + EGL    +S       P
Sbjct: 228 QANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLKP 272


>UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q3ZB94_DANRE
          Length = 271

 Score =  232 bits (592), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 107/256 (41%), Positives = 151/256 (58%), Gaps = 19/256 (7%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG+++ +G T+   P S+  D    SM  +    T V L  +P  + +    ++G+ L  
Sbjct: 1   MGNVTRQGHTN---PESNSLD----SMFKDCD--TLVVLADYPCRDISEPVFKMGDRLKG 51

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           +SEDG WW V+S  +G E ++P  +V+KV HGWL+EG+SR+KAEELL LPGN  G+FLIR
Sbjct: 52  LSEDGCWWKVRSLQTGTENYIPCNHVSKVYHGWLFEGVSRQKAEELLSLPGNSAGSFLIR 111

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES   RG YSLSVR         ++HY+I RL N W YISPRLTF  L  +V HYS+ +D
Sbjct: 112 ESPRERGLYSLSVRHR------SVKHYKIFRLTNSWYYISPRLTFQCLEDMVNHYSDSSD 165

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFL-EAPASGE--ASLL 237
           GICC L  PC+     P P      P  V   +L+W K+ +S L       S +   +++
Sbjct: 166 GICCVLSAPCLALS-NPTPSSIQGAPPVVMRRNLDWNKVKKSQLLNPSELDSVDSRDNMM 224

Query: 238 SEGLRESLSSYISLAE 253
           S G+R S+++Y+SL  
Sbjct: 225 SYGVRSSIAAYLSLTS 240


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 71/231 (30%), Positives = 115/231 (49%), Gaps = 26/231 (11%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREY----- 79
           S Q +RH    VAL  + A     LS R G+ L ++      WW  +     R+      
Sbjct: 37  SPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQL 96

Query: 80  --HMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSV 133
             ++PS YVA+     A  W +  + R  AE+ LL   N  G+FLIRES++++G +SLSV
Sbjct: 97  QGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSV 156

Query: 134 RLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
                     ++HYRI+RLD G  +++ R  F +L+  V HY++ +DG+C  L +PC+  
Sbjct: 157 LD-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKI 211

Query: 194 KLGPLPGKDTPPPVTVPTSSLN-WKKLDRSLLFLEAPASGEASLLSEGLRE 243
           ++        P P  +   +++ W+    S+  L+   SG+   + EGL  
Sbjct: 212 QV--------PAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWN 254


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 78/273 (28%), Positives = 122/273 (44%), Gaps = 31/273 (11%)

Query: 2   GSLSSRGKTSSPSPSSSGP--------------DQEPVSMQPERHKVTAVALGSFPAGEQ 47
           GSL SR    +P P+  GP                 P  +     K   VAL  + + ++
Sbjct: 55  GSLDSR---YTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDE 111

Query: 48  ARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREK 102
           + LS   G+ + +I + + DWW V +  + +E  +P  +VA+     +  W +E + R++
Sbjct: 112 SDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKE 171

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR 162
           A++LLL   NP G FL+R S+     YSLSV+         ++HYRI+ LDNG  YI+  
Sbjct: 172 ADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATN 231

Query: 163 LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
            TFPSL ALV  YS+ A G+C  L  PC   +       D  P +        ++     
Sbjct: 232 QTFPSLQALVMAYSKNALGLCHILSRPCPKPQ---PQMWDLGPELR-----DKYEIPRSE 283

Query: 223 LLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
           +  L     G    +  G  R S+   +    +
Sbjct: 284 IQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLRE 316


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  229 bits (585), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 79/242 (32%), Positives = 115/242 (47%), Gaps = 22/242 (9%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS- 62
           +S       P PS   P   P S  PE      VA+  +       L    GE + I+  
Sbjct: 31  VSQNFDPLIPYPSQYTP--PPSSPLPEN---LVVAIYKYDPAHSDDLGFEKGEKMKILDC 85

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFL 118
           +D +W+  +S  +G+  ++P  +VAK+       W Y+ LSR  A   LL PGN  G+FL
Sbjct: 86  DDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFL 145

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           IRES+T+ G +S+SVR   P   D I+HYRI+ +D G  YI+ +++F SL  LV+HYS  
Sbjct: 146 IRESETQPGSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSRE 205

Query: 179 ADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLS 238
           ADG+C  L +PC  +       +D             W+    SL        G+   + 
Sbjct: 206 ADGLCTRLVKPCQTRAPQKPWWQD------------EWEVPRESLKLERRLGQGQFGEVW 253

Query: 239 EG 240
            G
Sbjct: 254 MG 255


>UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homininae RepID=Q9H6Q3-2
          Length = 210

 Score =  229 bits (585), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 145/178 (81%), Positives = 154/178 (86%), Gaps = 1/178 (0%)

Query: 1   MGSLSSRGKTSSPSPSSSGPD-QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGSL SR K+      SS    Q PV+M+ ER K TAVALGSFPAG  A LSLRLGEPLT
Sbjct: 1   MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+SEDGDWWTV SEVSGREY++PSV+VAKV+HGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61  IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           RESQTRRG YSLSVRLSRPASWDRIRHYRI  LDNGWLYISPRLTFPSL ALV+HYSE
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178


>UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Tetraodontidae RepID=Q4SUZ3_TETNG
          Length = 232

 Score =  224 bits (571), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 96/252 (38%), Positives = 144/252 (57%), Gaps = 20/252 (7%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG++         + +  G  + P        +V  V L  +P+ E      R+GE L +
Sbjct: 1   MGNVFRSLSERPGANACEGAFKAP--------EVDLVVLQDYPSAEVCEPIYRMGEKLKL 52

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           ++++   W V+S  + +E ++P+ +VAKV HGWL+EG+ R+KAEELL LPGN  G+F++R
Sbjct: 53  VAQEAYGWRVRSVQTRQENYIPASHVAKVYHGWLFEGVERQKAEELLSLPGNRVGSFMVR 112

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES   RG YSLSV+         ++HYRI RLDN W YISP LTF  L  ++ HY    D
Sbjct: 113 ESTRERGSYSLSVKYR------SVKHYRIYRLDNSWYYISPSLTFQCLEDMINHY---CD 163

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           G+CC L  PC+   L   P   T PPV V   +  W+K++R  L   +  + + S+LS G
Sbjct: 164 GLCCALTSPCLSASLPAPPTSATAPPV-VMRRNFTWQKVNRRQL--TSVENCDDSVLSYG 220

Query: 241 LRESLSSYISLA 252
           +R S+++Y+S +
Sbjct: 221 VRNSIAAYLSFS 232


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  221 bits (562), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 69/224 (30%), Positives = 110/224 (49%), Gaps = 19/224 (8%)

Query: 30  ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV 89
           +      VA+  + A     L+   G+ L I  +  DWW  +S  +G++ ++P  YVA +
Sbjct: 62  DNTAKVVVAVYDYDARLDDDLTFVKGDLLEIREDTTDWWYARSRKNGKKGYIPGNYVAPI 121

Query: 90  ----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG----CYSLSVRLSRPASW 141
               A  W +  + R  AE+LL+  G+  G+FLIR+S+ + G    C++LSVR       
Sbjct: 122 QTLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVRDKEL--- 178

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
             IRHYRI+  D+G  +IS    F +L+ L+E Y   +DG+   L EPC  +K+  +  K
Sbjct: 179 --IRHYRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIKLLEPC--RKVCIMFKK 234

Query: 202 DTPPPVTVPTSSLN-WKKLDRSLLFLEAPASGEASLLSEGLRES 244
                 T   S  + W+    SL F     SG+   + +G+  S
Sbjct: 235 QVQ---TFGLSHKDKWEISRDSLEFQSRVGSGQFGDVYKGVWNS 275


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  220 bits (561), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 68/249 (27%), Positives = 112/249 (44%), Gaps = 21/249 (8%)

Query: 5   SSRGKTSSPSPSS---SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           SS      P+ SS   S PDQ    +     +++ +AL +F       LS   GE L + 
Sbjct: 19  SSNATQPKPNISSNFQSKPDQP-PPVPWRPPEMSYIALYAFQGRNDGDLSFEKGEVLKVF 77

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAF 117
            + GDWW   S  +  + ++P  YVA V      GW +   +R +A   L     P G F
Sbjct: 78  DQSGDWWVASSTRTNVQGYIPCNYVAPVNSLEVEGWFFGSCTRSEAIMRLQADNLPKGTF 137

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW--LYISPRLTFPSLHALVEHY 175
           L+RES+TR G Y+L+VR +       I++YR+ +  +G    +I+P+  F ++  +V+ +
Sbjct: 138 LVRESETRPGTYALTVRETDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVIDVVKFH 197

Query: 176 SELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEAS 235
           +    G+C  L +PC  Q            P T       W+    SL  L+    G+  
Sbjct: 198 TSQPGGLCSKLLKPCPKQ-----------TPNTRTLGHEVWELPRSSLKLLDKLGQGQFG 246

Query: 236 LLSEGLRES 244
            + +G+ + 
Sbjct: 247 AVWKGIYDG 255


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  217 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 74/263 (28%), Positives = 109/263 (41%), Gaps = 42/263 (15%)

Query: 22  QEPVSMQPE----RHKVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVS 75
           +EP   +P+       +   A   F    +  L  + G+ LTI +  ED +WW V+ + +
Sbjct: 6   KEPEGARPDILKPTKGMKCEAAYDFNGASKEDLPFKKGDILTIENPTEDPNWWLVR-DKT 64

Query: 76  GREYHMPSVYVAKV-------------------AHGWLYEGLSREKAEELLLLPGNPGGA 116
           GR   +P+ YV  +                      W +  +SRE AE LL+      G 
Sbjct: 65  GRTGMIPANYVELIGSDTKKTGTLPRDASGQLIPMPWFHGKISRELAESLLMP--REDGL 122

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FL+RES    G Y+L V        D++ HYR  +  NG L I   + F SL  LV+HY 
Sbjct: 123 FLVRESAHFPGDYTLCVCFQ-----DQVDHYR-MQGKNGKLTIDEEVYFSSLEELVQHYE 176

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
           + ADG+C  LR+P V Q                    +NW+   R ++      SG+   
Sbjct: 177 KDADGLCTRLRKPVVKQGGREFKIDA--------RKFVNWEISPREIVKSAQIGSGQFGD 228

Query: 237 LSEGLRESLSSYISLAEDPLDDA 259
           + EGL       I   +D   DA
Sbjct: 229 VFEGLYRGQKVAIKTLKDVQGDA 251


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 79/268 (29%), Positives = 124/268 (46%), Gaps = 39/268 (14%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVT---------------AVALGSFPAGEQA 48
           + S+ ++  P+  +S     P      +   T                VAL  + A  + 
Sbjct: 70  VKSKPQSCQPTNPTSNLAISPSHPSETQTVTTSKISGRSVKQLKPKHYVALFDYNARTEE 129

Query: 49  R--LSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREK 102
              LS R  E L +   D +WW VQ+  SGR+ ++PS +VAK     A  W    LSR+ 
Sbjct: 130 ETFLS-RRDEVLLLADTDSEWWLVQNLSSGRKGYVPSSFVAKKGSVEAEEWFMPMLSRKD 188

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR---PASWDRIRHYRIQRLDNGWLYI 159
           +E LLLL GN  G FL+RES+T +G  +LSVR          + ++HYRI+  D  + YI
Sbjct: 189 SERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTVKHYRIKHPDYRYYYI 248

Query: 160 SPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS---LNW 216
           + + +F SL  L++ YS  + G+CC L   C+            PPP+T   S     +W
Sbjct: 249 TTKCSFSSLQELIQFYSIDSHGLCCKLTRACL-----------CPPPITSDLSVKTKDHW 297

Query: 217 KKLDRSLLFLEAPASGEASLLSEGLRES 244
           +    S++ +E   +G+   + +G    
Sbjct: 298 EISKSSIVLIEKLGAGQFGEVWKGTWNG 325


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  213 bits (542), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 71/264 (26%), Positives = 117/264 (44%), Gaps = 27/264 (10%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQP-ERHKVTAVALGSFPAGEQARLSLRLGEPLTII- 61
           ++S  +    S ++    +E +   P E      VAL  F A     LS+  GE L ++ 
Sbjct: 33  VASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLG 92

Query: 62  -SEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGA 116
            + +G+W   Q++    +  +PS Y+  V     H W +  +SR  AE LL       G+
Sbjct: 93  YNHNGEWCEAQTKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLL--SSGINGS 148

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FL+RES++  G  S+S+R        R+ HYRI    +G LY+S    F +L  LV H+S
Sbjct: 149 FLVRESESSPGQRSISLRYE-----GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHS 203

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
            +ADG+   L  P         P ++ P    V  +   W+     +        G+   
Sbjct: 204 TVADGLITTLHYP--------APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGE 255

Query: 237 LSEGLRESLSSYI---SLAEDPLD 257
           + EG+ +  S  +   +L ED ++
Sbjct: 256 VYEGVWKKYSLTVAVKTLKEDTME 279


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  212 bits (540), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 62/227 (27%), Positives = 104/227 (45%), Gaps = 16/227 (7%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV---- 89
           T VAL  + +     LS + G+ + ++   + DWW V+ + +G+  ++P  +VAK     
Sbjct: 75  TLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIE 134

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA-SWDRIRHYR 148
           +  W    + R +AE L+L    P G FLIRE +     ++L++R +    +   ++HY+
Sbjct: 135 SEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYK 194

Query: 149 IQRLD-NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
           I+RLD +   +I+ R TF SL  LV +YS++ DG+CC L  P         P      P 
Sbjct: 195 IKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFP--------APRLAPTRPD 246

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAE 253
               +  NW+     L        G    +  G  R  +   I   +
Sbjct: 247 LSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMK 293


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score =  211 bits (538), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 67/268 (25%), Positives = 122/268 (45%), Gaps = 23/268 (8%)

Query: 1   MGSLSSRGKTSSPS--PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPL 58
           +  LS++ ++++    PS   P       +    K+   AL  F   E   L+LR  E  
Sbjct: 50  LSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEY 109

Query: 59  TIISE-DGDWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPG 111
            I+ + +  WW  +  + G E  +PS YV +        + W +  ++R +AE LL    
Sbjct: 110 LILEKYNPHWWKARDRL-GNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQES 168

Query: 112 NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHAL 171
              GAF++R+S+   G Y++SV +   ++   I+HY+I++ D+G  Y++ R  F S+  L
Sbjct: 169 KE-GAFIVRDSR-HLGSYTISVFMGARSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPEL 226

Query: 172 VEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPAS 231
           + ++   A G+   LR P  L          +  P T   S   W+     L F++   S
Sbjct: 227 IWYHQHNAAGLMTRLRYPVGLMG--------SCLPATAGFSYGKWEIDPSELAFIKEIGS 278

Query: 232 GEASLLSEGLRESLSSYISLAEDPLDDA 259
           G+  ++  G      S+I +A   +++ 
Sbjct: 279 GQFGVVHLG---EWRSHIQVAIKAINEG 303


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  210 bits (535), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 61/256 (23%), Positives = 110/256 (42%), Gaps = 23/256 (8%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           L+S    S  SP+S  P   PV+      +     +  + A     L++   E +TI+ E
Sbjct: 253 LASMRGPSGASPTSPAPASSPVAPAVVPERKQVRVMFDYIATAAGDLTIHKDEMITILEE 312

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLI 119
             +WW  Q++  G    +PS Y+ ++       W    +SR +A  +L +     G FL+
Sbjct: 313 RPNWWKAQNK-HGEVGFVPSNYLCRIQGLEGEPWFRGRISRAEAAAMLQIT-KQEGCFLV 370

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RES+T+ G Y+LS+  +     + +RHYRIQ ++ G  +++    F S+  L+E++    
Sbjct: 371 RESETQPGEYTLSLSHN-----EGVRHYRIQHIE-GQYFVNENHRFDSIPQLIEYHKLNG 424

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
            GI   LR              D   P++V      W+             SG+  ++ +
Sbjct: 425 GGIVTRLRR----------AINDANAPISVGLGHDMWELSRDEFELGRELGSGQFGIVQQ 474

Query: 240 G-LRESLSSYISLAED 254
              R   +  I + ++
Sbjct: 475 ARYRNGQAVAIKMMKE 490


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  209 bits (533), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 67/154 (43%), Positives = 92/154 (59%), Gaps = 4/154 (2%)

Query: 29  PERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           PE      VAL  +       LS + GE + ++ E G+WW  +S  + RE  +PS YVAK
Sbjct: 109 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLSTKREGFIPSNYVAK 168

Query: 89  V----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           V       W ++ ++R+ AE  LL PGN  GAFLIRES+T +G YSLSVR   P   D I
Sbjct: 169 VNTLETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDVI 228

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           +HY+I+ LDNG  YISPR+TFP +  ++++Y   
Sbjct: 229 KHYKIRSLDNGGYYISPRITFPCISDMIKYYQTN 262


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  209 bits (532), Expect = 7e-53,   Method: Composition-based stats.
 Identities = 62/235 (26%), Positives = 103/235 (43%), Gaps = 23/235 (9%)

Query: 25  VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPS 83
           +            +L  + A E   LSL  GE L I+ + +  WW  ++   G+E ++P+
Sbjct: 211 LPPGAAPALFEVQSLYDYDALEPTDLSLSKGERLVIVDQMEEHWWKARNNA-GQEGYIPA 269

Query: 84  VYVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
            YV K    +  W     S+  A  LL + G   GAFL+RES++  G YSLSV       
Sbjct: 270 NYVRKLGLESEPWFMADTSKAMASALLNMCGQ-DGAFLVRESESTPGSYSLSVFYQ---- 324

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPG 200
             +++HY+I + D     +S R TF S+  L+E++     G+   LR+P           
Sbjct: 325 -GKLKHYKI-KHDQDMYRVSERHTFASISELIEYHKHNGGGLVTRLRKPV---------- 372

Query: 201 KDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS-SYISLAED 254
           +D   P+T       W+   R +       SG   ++  G+ +S     I + ++
Sbjct: 373 QDANTPITAGLGHDRWELDAREIELGRELGSGNFGVVRAGVYKSNRPVAIKMMKE 427


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 68/268 (25%), Positives = 116/268 (43%), Gaps = 28/268 (10%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLGEPLT 59
           +G + S   +   S       +  ++  PE       VAL  F AG + +LSL+ GE + 
Sbjct: 155 LGGVHSSATSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVR 214

Query: 60  II--SEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNP 113
           I+  ++ G+W    S+ SG    +PS YV  +     H W +  +SR  AE LL      
Sbjct: 215 ILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL--SSGI 271

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVE 173
            G+FL+RES++  G  S+S+R        R+ HYRI    +G ++++    F +L  LV 
Sbjct: 272 NGSFLVRESESSPGQRSISLRYE-----GRVYHYRISEDPDGKVFVTQEAKFNTLAELVH 326

Query: 174 HYS--ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPAS 231
           H+S      G+  PL  P         P ++ P    +      W+     ++       
Sbjct: 327 HHSVPHEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGG 378

Query: 232 GEASLLSEGLRESLSSYI---SLAEDPL 256
           G+   + E + +   + +   +L ED +
Sbjct: 379 GQYGEVYEAVWKRYGNTVAVKTLKEDTM 406


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 65/237 (27%), Positives = 105/237 (44%), Gaps = 26/237 (10%)

Query: 30  ERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVA 87
           E      VAL  F A     LS+  GE L ++  +++G+W  V+S+    +  +PS Y+ 
Sbjct: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG--QGWVPSNYIT 163

Query: 88  KV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
            V     H W +  +SR  AE LL       G+FL+RES++  G  S+S+R        R
Sbjct: 164 PVNSLEKHSWYHGPVSRSAAEYLL--SSLINGSFLVRESESSPGQLSISLRYE-----GR 216

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           + HYRI    +G +Y++    F +L  LV H+S +ADG+   L  P         P  + 
Sbjct: 217 VYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--------APKCNK 268

Query: 204 PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYI---SLAEDPLD 257
           P    V      W+     +        G+   +  G+ +  S  +   +L ED ++
Sbjct: 269 PTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME 325


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  208 bits (529), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 60/266 (22%), Positives = 109/266 (40%), Gaps = 26/266 (9%)

Query: 5   SSRGKTSSPSPSSSGPDQ---------EPVSMQPERHKVTAVALGSFPAGEQARLSLRLG 55
           SS  KT  P P +   DQ            +          VAL  +       L LR G
Sbjct: 179 SSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKG 238

Query: 56  EPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK-----VAHGWLYEGLSREKAEELLLLP 110
           +   I+ E    W    + +G+E ++PS YV +       + W  + ++R +AE+LL   
Sbjct: 239 DEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQE 298

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI-RHYRIQRLDNGWLYISPRLTFPSLH 169
           G  GG F++R+S ++ G Y++SV          + RHY +        Y++ +  F ++ 
Sbjct: 299 GKEGG-FIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIP 356

Query: 170 ALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAP 229
            L+ ++   + G+   L+ P   Q        +   P T      +W+   + L FL+  
Sbjct: 357 ELINYHQHNSAGLISRLKYPVSQQ--------NKNAPSTAGLGYGSWEIDPKDLTFLKEL 408

Query: 230 ASGEASLLSEG-LRESLSSYISLAED 254
            +G+  ++  G  R      I + ++
Sbjct: 409 GTGQFGVVKYGKWRGQYDVAIKMIKE 434


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  207 bits (526), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 64/239 (26%), Positives = 105/239 (43%), Gaps = 26/239 (10%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVY 85
           Q +      VAL  F AG   +LSL+ GE + I+  ++ G+W        G+   +PS Y
Sbjct: 104 QEDDDPQLFVALYDFQAGGDNQLSLKKGEQVRILSYNKSGEWCEA-HASPGQVGWVPSNY 162

Query: 86  VAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           V  V     H W +  +SR  AE LL       G+FL+RES++  G  S+S+R       
Sbjct: 163 VTPVNSLEKHSWYHGPISRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYE----- 215

Query: 142 DRIRHYRI-QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPG 200
            R+ HYRI +   +G +Y++    F +L  LV H+S  +DG+   L  P         P 
Sbjct: 216 GRVYHYRINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLITQLLYP--------APK 267

Query: 201 KDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYI---SLAEDPL 256
            + P    +      W+     ++       G+   + E + +  +  +   +L ED +
Sbjct: 268 HNKPTVFALSPEPDEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTM 326


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  206 bits (525), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 67/263 (25%), Positives = 112/263 (42%), Gaps = 40/263 (15%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--S 62
           +S+    +P P    P                VAL  F AG + +LSL+ GE + I+  +
Sbjct: 174 TSKENLLAPGPEEDDPQ-------------LFVALYDFQAGGENQLSLKKGEQVRILSYN 220

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFL 118
           + G+W    S+ SG    +PS YV  +     H W +  +SR  AE LL       G+FL
Sbjct: 221 KSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL--SSGINGSFL 277

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS-- 176
           +RES++  G  S+S+R        R+ HYRI    +G ++++    F +L  LV H+S  
Sbjct: 278 VRESESSPGQRSISLRYE-----GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVP 332

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
               G+  PL  P         P ++ P    +      W+     ++       G+   
Sbjct: 333 HEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGE 384

Query: 237 LSEGLRESLSSYI---SLAEDPL 256
           + E + +   + +   +L ED +
Sbjct: 385 VYEAVWKRYGNTVAVKTLKEDTM 407


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  206 bits (525), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 67/263 (25%), Positives = 111/263 (42%), Gaps = 40/263 (15%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--S 62
           +S+     P P    P                VAL  F AG + +LSL+ GE + I+  +
Sbjct: 182 TSKENLLEPGPEEDDPQ-------------LFVALYDFQAGGENQLSLKKGEQVRILSYN 228

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFL 118
           + G+W    S+ SG    +PS YV  +     H W +  +SR  AE LL       G+FL
Sbjct: 229 KSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL--SSGINGSFL 285

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS-- 176
           +RES++  G  S+S+R        R+ HYRI    +G ++++    F +L  LV H+S  
Sbjct: 286 VRESESSPGQRSISLRYE-----GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVP 340

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
               G+  PL  P         P ++ P    +      W+     ++       G+   
Sbjct: 341 HEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGE 392

Query: 237 LSEGLRESLSSYI---SLAEDPL 256
           + E + +   + +   +L ED +
Sbjct: 393 VYEAVWKRYGNTVAVKTLKEDTM 415


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  206 bits (524), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 67/263 (25%), Positives = 112/263 (42%), Gaps = 40/263 (15%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--S 62
           +S+    +P P    P                VAL  F AG + +LSL+ GE + I+  +
Sbjct: 193 TSKENLLAPGPEEDDPQ-------------LFVALYDFQAGGENQLSLKKGEQVRILSYN 239

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFL 118
           + G+W    S+ SG    +PS YV  +     H W +  +SR  AE LL       G+FL
Sbjct: 240 KSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL--SSGINGSFL 296

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS-- 176
           +RES++  G  S+S+R        R+ HYRI    +G ++++    F +L  LV H+S  
Sbjct: 297 VRESESSPGQRSISLRYD-----GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVP 351

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
               G+  PL  P         P ++ P    +      W+     ++       G+   
Sbjct: 352 HEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGE 403

Query: 237 LSEGLRESLSSYI---SLAEDPL 256
           + E + +   + +   +L ED +
Sbjct: 404 VYEAVWKRYGNTVAVKTLKEDTM 426


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  206 bits (524), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 72/272 (26%), Positives = 120/272 (44%), Gaps = 33/272 (12%)

Query: 2   GSLSSRGKTSSPSPSSS-----GPDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLG 55
           G+L S+G +++   S          +  ++  PE       VAL  F AG + +LSLR G
Sbjct: 95  GTLHSQGSSNTAQSSFENAHRWTSKENLLAPGPEEDDPQLFVALYDFKAGGENQLSLRKG 154

Query: 56  EPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLL 109
           E + I+  ++ G+W    S+ SG    +PS YV  +     H W +  +SR  AE LL  
Sbjct: 155 EQVRILSYNKSGEWCEAHSD-SGHVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL-- 211

Query: 110 PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLH 169
                G+FL+RES++  G  S+S+R        R+ HYRI    +G +Y++    F +L 
Sbjct: 212 SSGINGSFLVRESESSPGQRSISLRYD-----GRVYHYRISEDSDGKVYVTAEAKFNTLA 266

Query: 170 ALVEHYS--ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            LV H+S      G+  PL  P         P ++ P    +      W+     ++   
Sbjct: 267 ELVHHHSVLHEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIVMKH 318

Query: 228 APASGEASLLSEGLRESLSSYI---SLAEDPL 256
               G+   + E + +   + +   +L ED +
Sbjct: 319 KLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTM 350


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  206 bits (523), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 64/259 (24%), Positives = 111/259 (42%), Gaps = 27/259 (10%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           L +      P+P +     +  S          VAL  F A E   LSL       +I +
Sbjct: 319 LDANMPGGIPTPGTPNSKAKDNSH----FVKLVVALYPFKAIEGGDLSLEKNAEYEVIDD 374

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAF 117
             + W    +  G   ++PS YV   A      + W    +SR++AE LL   G+  G F
Sbjct: 375 SQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLL-KQGDKEGCF 433

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           ++R+S T+ G Y+LS+    P S   ++HY I++      Y+S +    ++  L+ ++  
Sbjct: 434 VVRKSSTK-GLYTLSLHTKVPQS--HVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRH 490

Query: 178 LADGICCPLR-EPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
            + G+ C L+  PC           D P P T   S   W+     L+ +E   SG+  +
Sbjct: 491 NSGGLACRLKSSPC-----------DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGV 539

Query: 237 LSEG-LRESLSSYISLAED 254
           +  G  R S+ + + + ++
Sbjct: 540 VRRGKWRGSIDTAVKMMKE 558


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score =  204 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 71/176 (40%), Positives = 97/176 (55%), Gaps = 7/176 (3%)

Query: 13  PSPSSSG--PDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWT 69
           P P + G  P     S+ P        +AL S+       L    GE L I+ + G+WW 
Sbjct: 98  PHPVTPGFLPIPARFSLMPLVFTDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWK 157

Query: 70  VQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
            QS  +G+E  +P  +VAK        W ++ LSR+ AE  LL PGN  G+FLIRES++ 
Sbjct: 158 AQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESEST 217

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG 181
            G +SLSVR       + ++HY+I+ LDNG  YISPR+TFP LH LV HY+   +G
Sbjct: 218 AGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTRYYNG 273


>UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californica
           RepID=B6DVV3_APLCA
          Length = 517

 Score =  202 bits (515), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 74/263 (28%), Positives = 124/263 (47%), Gaps = 31/263 (11%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G +     + + SPS+ G    P+   P R++    AL +F A  Q  LS R G+ + I 
Sbjct: 32  GRVDLNASSGTSSPSTDGL--RPLPRVPARNR--VRALYNFEAINQDDLSFRKGDLMEID 87

Query: 62  S---EDGDWWTVQSEVSGREYHMPSVYVAK-----VAHGWLYEGLSREKAEELLLLPGNP 113
               E  DWW      +  + ++PS YVAK         W +E   R++++++LLLPGNP
Sbjct: 88  ETSPETDDWWLAVHLKTKNKGYIPSNYVAKDDATPQTQDWWFE-FDRKESDKMLLLPGNP 146

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWD-RIRHYRIQRLDN-GWLYISPRLTFPSLHAL 171
            G FL+RE+ T +  Y LSVR +  AS +  ++HYR++++D+    +IS + TF +L  +
Sbjct: 147 RGTFLVREA-TDKSTYVLSVRDNDKASGEPCVKHYRVRKMDDERGYFISAKKTFKTLFDV 205

Query: 172 VEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPAS 231
           +EHY + +DG+CC L   C              P           +     +       +
Sbjct: 206 IEHYKDNSDGLCCQLGAAC--------------PRSRPTVQFRELEIKREVIELTNKLGA 251

Query: 232 GEASLLSEG-LRESLSSYISLAE 253
           G    + +G LR+ +   +   +
Sbjct: 252 GCFGEVWKGKLRKVVEVAVKTLK 274


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  202 bits (513), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 65/261 (24%), Positives = 110/261 (42%), Gaps = 25/261 (9%)

Query: 10  TSSPSPSSSGPDQEPVSMQPERH------KVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
            ++  PS  G  Q   S + +R+          V + +F    +  LS   GE LT++  
Sbjct: 34  AAAAGPSQPGSRQRQPSHRADRYPREPQVGDVFVGVYNFQGRTEPELSFERGEKLTLLRR 93

Query: 64  -DGDWWTVQSEVSGREYHMPSVYVAKVAH----GWLYEGLSREKAEELLLLPGNPGGAFL 118
            D +WW ++S+ SG+E + PS Y+A         W +  +SR  AE LL       G+FL
Sbjct: 94  LDENWWLMRSQRSGKEGYAPSNYIAPFKDINRNPWYHSNISRNTAEYLL--KSGVDGSFL 151

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           +RES +  G YS+++R    A      HYRI     G  +++    F ++  LV H++ +
Sbjct: 152 VRESLSSPGEYSITLRCDGKAR----THYRINHDARG-YFVAAGKFFATVEQLVAHHAVV 206

Query: 179 ADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLS 238
           ADG+   L++        P+   +  P V        W+     ++       G+   + 
Sbjct: 207 ADGLVACLKQ-------HPVEKAEAKPLVLSKEEDEQWEIARSEIVLGHRLGEGQYGEVY 259

Query: 239 EGLRESLSSYISLAEDPLDDA 259
            G        I   +D   +A
Sbjct: 260 VGEWGPHRVAIKTIKDGAMEA 280


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  197 bits (502), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 62/234 (26%), Positives = 102/234 (43%), Gaps = 21/234 (8%)

Query: 11  SSPSPSSSGPDQEPVSM-QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWT 69
           + P      P + P S   PE       AL ++ A     L L+ GE L ++S + ++W 
Sbjct: 172 AEPRAEEEAPPRPPKSAAPPEVVLFEVTALFNYNATNPDDLDLKQGETLEVLSTEEEFWW 231

Query: 70  VQSEVSGREYHMPSVYVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
                +G+   +PS YVAK    +  W    +SR +A+  L +  N  G FL+RES+T  
Sbjct: 232 RARNSAGKVGMIPSNYVAKPGFESEPWYVGKMSRVEAQSKLQIF-NLDGTFLVRESETSA 290

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           G Y+LSV  +        R+YRIQ  D    YI+ R    ++  L++++     G+C  L
Sbjct: 291 GSYTLSVYFNGQP-----RNYRIQ-HDGNEYYITTRHRQKTIKELIDYHKLNGGGLCTRL 344

Query: 187 REPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           ++P            D   P      S  W+     +   +   SG+  ++ +G
Sbjct: 345 KKP----------ACDDEAPTPHDLGSDKWEIDPSEISLGKVLGSGQFGVVYKG 388


>UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B0B45
          Length = 287

 Score =  197 bits (500), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 85/225 (37%), Positives = 128/225 (56%), Gaps = 30/225 (13%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
            +V  V L  +P+ E      R+GE L +++++   W V+S  + +E ++P+ +VAKV H
Sbjct: 61  PEVDLVVLQDYPSAEVCEPIYRMGEKLKLVAQEAYGWRVRSVQTRQENYIPASHVAKVYH 120

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           GWL+EG+ R+KAEELL LPGN  G+F++RES   RG YSLSV+         ++HYRI R
Sbjct: 121 GWLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVKYR------SVKHYRIYR 174

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
           LDN W YISP LTF  L  ++ HY + ADG+                       P  V  
Sbjct: 175 LDNSWYYISPSLTFQCLEDMINHYCDFADGL----------------------SPPVVMR 212

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPL 256
            +  W+K++R  L   +  + + S+LS G+R S+++Y+S +E P 
Sbjct: 213 RNFTWQKVNRRQL--TSVENCDDSVLSYGVRNSIAAYLSFSEGPE 255


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  195 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 59/258 (22%), Positives = 104/258 (40%), Gaps = 31/258 (12%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEP----------VSMQPERHKVTAVALGSFPAGEQARLSL 52
           +  S    S P PS+      P          V    E      V L  F  G + +L++
Sbjct: 81  NFPSDTIQSRPLPSTPTHATSPDIAGWNSTEDVCGGDEHDPDLFVVLYDFNGGVENQLTV 140

Query: 53  RLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEEL 106
           R G+ + I+  ++ G+W   +   +G+   +P  YV        H W +  +SR  AE L
Sbjct: 141 RKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPVTYVTPFNSLEKHSWYHGPISRNAAEYL 200

Query: 107 LLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFP 166
           L       G+FL+R+S++  G  S+S+R        R+ HYRI    +G ++++    F 
Sbjct: 201 L--SSGIDGSFLVRDSESSPGHRSISLRFD-----GRVYHYRISSGSDGKVFVTTESKFS 253

Query: 167 SLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFL 226
           ++  LV H+ + +DG+   LR P    +   + G    P          W+     +   
Sbjct: 254 TIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLP--------DEWEIERTDISMK 305

Query: 227 EAPASGEASLLSEGLRES 244
                G+   + E + + 
Sbjct: 306 NKLGGGQYGEVYEAIWKK 323


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score =  195 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 75/257 (29%), Positives = 111/257 (43%), Gaps = 34/257 (13%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWT 69
           S+ SP  SG    P+        V   AL S+    Q  LS + G+ + +IS   D WW 
Sbjct: 16  STVSPGGSGVQARPL--------VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWF 67

Query: 70  VQSEVSGREYHMPSVYVA------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +   +G   ++PS YV            W    + R +A+  LLL GNP G +LIR S 
Sbjct: 68  ARHSDTGISGYIPSNYVCLNDGLPTSLDAWY--NIGRREADRKLLLVGNPKGTYLIRPS- 124

Query: 124 TRRGCYSLSVRLSRPA-SWDRIRHYRIQRLDN-GWLYISPRLTFPSLHALVEHYSELADG 181
           +    Y+LSVR      +   ++HYRI+ LDN G  +IS R TFP++  LV +Y+   DG
Sbjct: 125 SETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDG 184

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG- 240
           +CC L  PC             P     P    +++    S+  +     G    +    
Sbjct: 185 LCCRLSIPC-------------PRAYRPPVQFRDFEINRDSITRIRKLGQGTFGEVYLAK 231

Query: 241 LRESLSSYISLAEDPLD 257
              S+   + +  DP D
Sbjct: 232 WNGSVEVAVKMRLDPTD 248


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  195 bits (495), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 64/252 (25%), Positives = 103/252 (40%), Gaps = 20/252 (7%)

Query: 14  SPSSSGPDQEPVSMQPE---RHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWW 68
           S S SG    P+S        +    VA   F    +  L  + G+ + I+  + D +W+
Sbjct: 2   SNSMSGNSGNPMSGNSSKNFPNGTECVARYDFKGNSEKDLPFKKGDIIEILQSTRDPNWY 61

Query: 69  TVQSEVSGREYHMPSVYVAK------VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
             +    GR   +P  YV +          W +  ++REKAEELL       G FL+RES
Sbjct: 62  NAKKVSDGRTGLIPINYVQQRRALHLHEMPWFFGKITREKAEELL--TPREVGLFLVRES 119

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
               G Y+L V    P +  ++ HYR+    +  + +     FP+L  L++HY + ADG+
Sbjct: 120 TNFPGDYTLCVV--SPQNNKKVEHYRVISTSDNQVTVDEEAFFPTLIELIKHYEKDADGL 177

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
           C  L++P + +K   L                 W      + F E    GE   + +G+ 
Sbjct: 178 CTMLKKP-LKKKTEILQSAIFK----ESFQKEGWAVPIEDVEFKELIGKGEFGNVYKGVW 232

Query: 243 ESLSSYISLAED 254
              +  I    D
Sbjct: 233 AKKTVAIKKLRD 244


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  193 bits (491), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 69/261 (26%), Positives = 109/261 (41%), Gaps = 37/261 (14%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKV----------------TAVALGSFPAGEQARLSL 52
                 P    PDQ  V   P+ HK                   VA   FP  E   L L
Sbjct: 155 TPKEKKPLPPTPDQNQVMPSPQLHKNCPSALSRPLPPVPEFQQVVAKFDFPGIEAQDLPL 214

Query: 53  RLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEE 105
             G    I+ + +  WW  Q E  GRE  +PS YV  +       + W  + ++R KAE+
Sbjct: 215 VKGCTYVILDDKNPHWWRAQDEE-GREGLIPSTYVYPLTRFDLEQNRWFCKDITRAKAEQ 273

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTF 165
           LL   G+  G+FL+RES ++ G  ++SV    P   + ++HY +++L  G  Y++ + TF
Sbjct: 274 LLRQAGSE-GSFLVRES-SQVGKLTVSVYSCIPC--EVVKHYHVKQLPTGEWYLAEKHTF 329

Query: 166 PSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF 225
            ++  L+ ++   A G+   LR P         PG++   P T   S   W+     L  
Sbjct: 330 STISDLIHYHQHNAAGLVTRLRHPVR-------PGEEL--PSTAGLSYGKWELDALELTS 380

Query: 226 LEAPASGEASLLSEGLRESLS 246
           L     G   ++  G+   + 
Sbjct: 381 LRELGRGALGVVQLGMWRGVR 401


>UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QLS5_SCHMA
          Length = 801

 Score =  193 bits (491), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 68/210 (32%), Positives = 107/210 (50%), Gaps = 16/210 (7%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAK----VAH 91
           VA+  + A     +S R G+ L ++   D +WW V+   SG+  ++PS Y+A+     A 
Sbjct: 339 VAIFDYEAHTSEEVSARKGDQLRVLDLSDSEWWLVEH--SGQVGYIPSSYLAQANSVEAE 396

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +SR+ +E LLLL GN  G FL+R S+T  G  SLSVR +     + ++HY+I++
Sbjct: 397 DWYFRSISRKDSERLLLLKGNIRGTFLVRASETTNGALSLSVRDTEQQRGETVKHYKIKQ 456

Query: 152 -LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             +   +YI+ +  FP L +LV HYS  ADG+CC L          P P     P     
Sbjct: 457 SSETNDVYITTKQVFPDLKSLVIHYSNQADGLCCCLTR--------PCPRPPPVPTDLSR 508

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
            +   W+    SL  +E   +G+   + +G
Sbjct: 509 LTRDQWEISRSSLKLIELLGAGQFGEVWKG 538


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score =  192 bits (489), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 75/257 (29%), Positives = 111/257 (43%), Gaps = 34/257 (13%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWT 69
           S+ SP  SG    P+        V   AL S+    Q  LS + G+ + +IS   D WW 
Sbjct: 100 STVSPGGSGVQARPL--------VQVRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWF 151

Query: 70  VQSEVSGREYHMPSVYVA------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +   +G   ++PS YV            W    + R +A+  LLL GNP G +LIR S 
Sbjct: 152 ARHSDTGISGYIPSNYVCLNDGLPTSLDAWY--NIGRREADRKLLLVGNPQGTYLIRPS- 208

Query: 124 TRRGCYSLSVRLSRPA-SWDRIRHYRIQRLDN-GWLYISPRLTFPSLHALVEHYSELADG 181
           +    Y+LSVR      +   ++HYRI+ LDN G  +IS R TFP++  LV +Y+   DG
Sbjct: 209 SETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDG 268

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG- 240
           +CC L  PC             P     P   + +  +  S+  +     G    +    
Sbjct: 269 LCCRLSIPC-------------PRAYRPPVHFVMFAIIRDSITRIRKLGQGTFGEVYLAK 315

Query: 241 LRESLSSYISLAEDPLD 257
              S+   + +  DP D
Sbjct: 316 WNGSVEVAVKMRLDPTD 332


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score =  192 bits (488), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 62/263 (23%), Positives = 105/263 (39%), Gaps = 24/263 (9%)

Query: 5   SSRGKTSSPSPSSSG--PDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           SS  K   P+P +    P       + +  +   VA+  F A E   L L  G+   I+ 
Sbjct: 151 SSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILE 210

Query: 63  EDG-DWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGG 115
           ++   WW  + +  G E ++PS YV          + W    ++R KAE+LL      GG
Sbjct: 211 KNDVHWWRARDKY-GNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGG 269

Query: 116 AFLIRESQTRRGCYSLSVRLSRPASW-DRIRHYRIQRLDN--GWLYISPRLTFPSLHALV 172
            F++R+S ++ G Y++S+            RHY I+         Y++ +  F S+  ++
Sbjct: 270 -FMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEII 327

Query: 173 EHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASG 232
           E++   A G+   LR P  ++            P T   S   W+     L F+    SG
Sbjct: 328 EYHKHNAAGLVTRLRYPVSVKGKNA--------PTTAGFSYEKWEINPSELTFMRELGSG 379

Query: 233 EASLLSEG-LRESLSSYISLAED 254
              ++  G  R      I    +
Sbjct: 380 LFGVVRLGKWRAQYKVAIKAIRE 402


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  192 bits (487), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 66/264 (25%), Positives = 100/264 (37%), Gaps = 32/264 (12%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDG 65
           GK     P + GP  E  S+    +  T   +  F  G +  L  + G+ L +I  + D 
Sbjct: 7   GKLIDTGPVTRGPSYENHSLTTIPNGTTCEGVFDFNTGNKGDLPFKKGDTLVVIQRTRDP 66

Query: 66  DWWTVQSEVSGREYHMPSVY---------------VAKVAHGWLYEGLSREKAEELLLLP 110
           +W+  Q+   G    +P  Y               V   A  W +  ++R  AE+LL   
Sbjct: 67  NWYRAQN-SKGESGMVPLNYITQSNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLL--T 123

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHA 170
               G FL+RES    G Y++ V          + HYR+   DN  + I     F +L  
Sbjct: 124 PRKDGLFLVRESTNYPGDYTMCVSF-----AGEVEHYRVIFKDN-KVTIDEEEYFENLTK 177

Query: 171 LVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
           LVEHY   ADG+ C L +P +++K G     D     T       W      L       
Sbjct: 178 LVEHYERDADGLVCTLTQP-LIKKGGHEYSVD-----TEEFRKSGWAINFTDLKLGTILG 231

Query: 231 SGEASLLSEGLRESLSSYISLAED 254
            G+   + EG  +     +   +D
Sbjct: 232 KGDFGDVYEGTYKDQKVAVKSVKD 255


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  190 bits (483), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 65/235 (27%), Positives = 108/235 (45%), Gaps = 26/235 (11%)

Query: 23  EPVSMQPE-RHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREYH 80
            P    P+   +   VAL  +       L++  G+   I+ +   DWW  +   +G   +
Sbjct: 146 NPSHNSPQIPTEGQFVALHDYVKRVDDDLNMTKGQIFNILDNSHCDWWYAECVSTGNRGY 205

Query: 81  MPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
           +P  ++A V    ++ W +  L R +AE  L LPGN  G+FL+R S+++   YSLSVR  
Sbjct: 206 VPKNHLAAVTSLESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVR-- 263

Query: 137 RPASWDRIRHYRIQ----RLDN--GWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
                + ++HYRI+    R D      YIS +L F ++  LV HY E   G+CC L +PC
Sbjct: 264 ---EENTVKHYRIRSRYSRTDPTLKRFYISRQLPFVNIQQLVNHYLENQSGLCCRLGKPC 320

Query: 191 VLQKLGPLPGKDTPPPVTVPTSSLN-WKKLDRSLLFLEAPASGEASLLSEGLRES 244
           +            P PV +    ++ W+    S++  E    G+   + + +   
Sbjct: 321 IRPT--------HPEPVGLSHKLIDKWEIPKSSIILKEKIGQGQFGEVFKAVWNK 367


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  189 bits (480), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 64/231 (27%), Positives = 102/231 (44%), Gaps = 24/231 (10%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQP-ERHKVTAVALGSFPAGEQARLSLRLGEPLTII- 61
           ++S  +    S ++    +E +   P E      VAL  F A     LS+  GE L ++ 
Sbjct: 285 VASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLG 344

Query: 62  -SEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGA 116
            + +G+W   Q++    +  +PS Y+  V     H W +  +SR  AE LL       G+
Sbjct: 345 YNHNGEWCEAQTKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRNAAEHLL--SSGINGS 400

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FL+RES++  G  S+S+R        R+ HYRI    +G LY+S    F +L  LV H+S
Sbjct: 401 FLVRESESSPGQRSISLRYE-----GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHS 455

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            +ADG+   L  P         P ++ P    V  +   W+     +    
Sbjct: 456 TVADGLITTLHYP--------APKRNKPSVYGVSPNYDKWEMERTDITMKH 498


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  189 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 59/232 (25%), Positives = 108/232 (46%), Gaps = 21/232 (9%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA 87
           +P+      +A+  +P  E+  L L  G+ +T+     ++W    +  G E ++PS YV 
Sbjct: 250 EPKPSDFDVIAMYDYPGLERGDLPLVKGQRVTVFDATREFWWRARDEQGSEGYIPSNYVK 309

Query: 88  KV---AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           K+   +  W +  LSR +AE +L   G  GG F++R S +R   Y+LS+         ++
Sbjct: 310 KMGLDSEEWFFPQLSRTRAENILKGEGREGG-FVVRNS-SRENMYTLSI-----CHEGQV 362

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           RHY I+  ++   +IS +  FPS+  L+E++     G+   LR+P         P +  P
Sbjct: 363 RHYHIKLDESNKYFISEKHRFPSIKELIEYHKLNGGGLVTRLRKP---------PVQLAP 413

Query: 205 PPVTV-PTSSLNWKKLDRSLLFLEAPASGEAS-LLSEGLRESLSSYISLAED 254
            P ++ P     W+    SL   +   SG+   ++S   +  +   I +  +
Sbjct: 414 NPQSLGPLFDEAWEIDKVSLSLGKELGSGQFGRVVSGKWKGKIDVAIKMMRE 465


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 54/228 (23%), Positives = 96/228 (42%), Gaps = 23/228 (10%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAK-- 88
             +    + S  A     LS+  G+ L +I + + +WW  + +  GR  ++PS YV +  
Sbjct: 238 KMLEVRVMYSHNATTPGDLSITEGDKLWVIDQSEPNWWKAR-DSQGRVGYIPSNYVRQAG 296

Query: 89  -VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  +SR +A  LL +     G FL+RES+++ G YSLSV     +  D +RHY
Sbjct: 297 IESEAWFHGRISRAEAAALLHVA-KQEGCFLVRESESKVGEYSLSV-----SHGDSLRHY 350

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            I++ +    YI+ R  FP +  L+E++   + G+   LR+             D   P 
Sbjct: 351 HIKK-EGEEFYINDRHRFPDICKLIEYHKLNSGGLVTRLRK----------SIADLHTPA 399

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR-ESLSSYISLAED 254
                   W+             SG+  ++ E          + + + 
Sbjct: 400 AAGLGHGKWELDPADFAIGRQLGSGQFGVVHEATYIGEKKVAVKMMKQ 447


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  186 bits (471), Expect = 9e-46,   Method: Composition-based stats.
 Identities = 60/241 (24%), Positives = 103/241 (42%), Gaps = 33/241 (13%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVS-----------GREYHMP 82
            VAL  F    + +LSLR G+ + I+  +++ +W   +   +           G    +P
Sbjct: 120 FVALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVP 179

Query: 83  SVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
           S ++A       + W +  +SR  +E +L       G+FL+RES+T  G Y++SVR    
Sbjct: 180 SNFIAPYNSLDKYTWYHGKISRSDSEAIL--GSGITGSFLVRESETSIGQYTISVRHD-- 235

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
               R+ HYRI   +   ++I+  + F +L  LV H+S  ADG+ C L  P   +  G  
Sbjct: 236 ---GRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRG 292

Query: 199 PGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYI---SLAEDP 255
                      P +   W+     ++       G+   + EG  +     I   +L ED 
Sbjct: 293 LFS------LSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDA 346

Query: 256 L 256
           +
Sbjct: 347 M 347


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  184 bits (466), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 23/209 (11%)

Query: 25  VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMP 82
           ++   E      VAL  F A     LS+  GE L ++  + +G+W   Q++    +  +P
Sbjct: 394 LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 451

Query: 83  SVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
           S Y+  V     H W +  +SR  AE LL       G+FL+RES++  G  S+S+R    
Sbjct: 452 SNYITPVNSLEKHSWYHGPVSRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYE-- 507

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
               R+ HYRI    +G LY+S    F +L  LV H+S +ADG+   L  P         
Sbjct: 508 ---GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--------A 556

Query: 199 PGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
           P ++ P    V  +   W+     +    
Sbjct: 557 PKRNKPTVYGVSPNYDKWEMERTDITMKH 585


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  183 bits (464), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 63/232 (27%), Positives = 99/232 (42%), Gaps = 30/232 (12%)

Query: 31  RHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAK 88
                 +A  +F    +  L    G+ LTI+  ++D +W+  +++V GRE  +P+ YV K
Sbjct: 9   PSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQK 67

Query: 89  VA----------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
                         W +  ++RE+AE LL  P    G FL+RES    G Y+L V     
Sbjct: 68  REGVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCD-- 123

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
               ++ HYRI    +  L I   + F +L  LVEHY+  ADG+C  L +P V++  G +
Sbjct: 124 ---GKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVME--GTV 177

Query: 199 PGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYIS 250
             +D             W    + L  L+    GE   +  G        + 
Sbjct: 178 AAQDE-------FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVK 222


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  182 bits (463), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 76/264 (28%), Positives = 114/264 (43%), Gaps = 34/264 (12%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQP----ERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
            + G+    +P S  P+ +PV   P           +AL  F A     LS+R G+ L  
Sbjct: 21  PAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCA 80

Query: 61  ISEDGDWWTVQSEVSGRE--YHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGN 112
           + E G +   +  +SG+     +P  +VAK +        W + G+SR +A++LLL P N
Sbjct: 81  LEEGGGYIFAR-RLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPN 139

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             GAFLIR S++  G YSLSVR        ++ HYR+    +G LY+     FP L  L+
Sbjct: 140 EPGAFLIRPSESSLGGYSLSVRAQA-----KVCHYRVSMAADGSLYLQKGRLFPGLEELL 194

Query: 173 EHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASG 232
            +Y      I  PL +PC+ QK    P +D             W++             G
Sbjct: 195 TYYKANWKLIQNPLLQPCMPQK---APRQDV------------WERPHSEFALGRKLGEG 239

Query: 233 EASLLSEGLR-ESLSSYISLAEDP 255
               + EGL   SL   I + +  
Sbjct: 240 YFGEVWEGLWLGSLPVAIKVIKSA 263


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  182 bits (461), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 62/231 (26%), Positives = 110/231 (47%), Gaps = 23/231 (9%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDG--DWWTVQSEVSGREYHMPSVYVA----K 88
           T VAL     G    + LR G+ L  +++D   +W  V++ V+G +  +P+ ++A     
Sbjct: 173 TFVALYDHTPGCAKEMLLRAGDMLLRVNKDPSKEWTLVENCVTGCQGFVPTSFIAASASL 232

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            +H W +  ++R KAE+ L  P    G+FLIRES++  G YSLS+R       D +RHYR
Sbjct: 233 ESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRD-----GDTVRHYR 287

Query: 149 IQRLDNGWLYI--SPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPP 206
           ++  + G   +  SP   F SL  L+  + +   G+   LREPC        P +  P  
Sbjct: 288 VENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATALREPC--------PKESAPMA 339

Query: 207 VTVPTSSLNWKKLDR-SLLFLEAPASGEASLLSEGL-RESLSSYISLAEDP 255
             +   + +  ++ R S+   +   +G+   +  G+ ++S    +   +  
Sbjct: 340 SDLTFDTHDQWEVPRTSIKLGKLLGTGQYGEVYSGIFQDSTKVAVKTLKAA 390


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  181 bits (459), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 52/235 (22%), Positives = 94/235 (40%), Gaps = 22/235 (9%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPS 83
           M   +     VAL  + +  +  LS   G+   I+     D  WW  Q+  + ++  +P 
Sbjct: 1   MSATKKNDIFVALDDYASQHKGELSFSKGDNFKILKNAAPDDGWWNAQNLNTKKKGWIPC 60

Query: 84  VYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
             VA         W +  +SR  A+ LL   G   G +L+RESQ++ G Y+L V     +
Sbjct: 61  SLVALDGSLELFDWCHGAISRNGADYLLKQHG-IDGMYLVRESQSQPGQYTLDVWKEGKS 119

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLP 199
                 HYRI + D G+ +    + FP++  L++H+   +DG+C  L            P
Sbjct: 120 V-----HYRITKGDEGYFF-RQGVCFPTIPELIQHHQTRSDGLCSSLDHI--------AP 165

Query: 200 GKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                  V        W+     ++  +    G    + +G+  + +  I   ++
Sbjct: 166 KAHAKTIVIGMDMEKKWELKRSEVILGDRLGGGNYGEVFKGIYNNKTVAIKTIKE 220


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  180 bits (457), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 68/268 (25%), Positives = 100/268 (37%), Gaps = 56/268 (20%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV- 89
               +   +FP      L  + G+ L I+  S+D +W+  + E  G E  +P  YV +  
Sbjct: 8   GTECIGKYNFPGSSPHDLPFKKGDRLVIVAPSKDPNWYKARRE-DGLEGMIPFNYVQEKV 66

Query: 90  ---------------------------------------AHGWLYEGLSREKAEELLLLP 110
                                                     W +  +SRE AE+LL  P
Sbjct: 67  PVAGSAPQPPQRPVLSAPQPVADNDAAMNHASKGAVQLKTMPWFHGRISREDAEKLLTPP 126

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHA 170
            N  G FL+RESQ   G Y+L V         R+ +YR++R + G + +     F +L  
Sbjct: 127 KN--GRFLVRESQNYPGDYTLCVSYD-----GRVENYRVRRNEKGLVTVDDDEYFDNLIK 179

Query: 171 LVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
           LVEHY + ADG+C  L+ P V ++   L   D             W     SLL      
Sbjct: 180 LVEHYQKEADGLCTRLKAP-VDKEGQHLFVVDVND-----FKEKGWAIPKASLLKKSLIG 233

Query: 231 SGEASLLSEGLRESLSSYISLAEDPLDD 258
            GE   +  G  E     +   +D L D
Sbjct: 234 KGEFGEVWLGDYEGKKVAMKSMKDHLKD 261


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  180 bits (457), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 58/215 (26%), Positives = 90/215 (41%), Gaps = 25/215 (11%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQ--SEVSGR--EYHMPSVYVAK---- 88
           V L  F +     LS R G+   +  ++  WW      E  G   + ++P  Y+A+    
Sbjct: 14  VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            +  W +  +SR +A   L   GN  GAFLIR S+     Y LSVR +       +RHY+
Sbjct: 74  ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT-----QAVRHYK 128

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I R   G L+++  ++F SL  LV ++   +      L  PC   +  PLP  D      
Sbjct: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWD------ 182

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
                 +W++            SG    + EGL +
Sbjct: 183 ------DWERPREEFTLCRKLGSGYFGEVFEGLWK 211


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  179 bits (455), Expect = 7e-44,   Method: Composition-based stats.
 Identities = 58/240 (24%), Positives = 104/240 (43%), Gaps = 27/240 (11%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV--- 89
               VAL          LS+R  + L  +  DG W   +  ++  E  +P  +VA     
Sbjct: 277 GKVVVALYDNDPRGDMELSMRKDDYLLELRSDGAWVQCRHLMTNEEGFVPGTFVAPYKSL 336

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            A  W +  ++R KAE+LL +P    G FLIRES++  G +SLS++       + +RH+R
Sbjct: 337 EAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKD-----GENVRHFR 391

Query: 149 IQRLDNG-WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
           ++++  G  L  SP      L +L++++     G+   L+ PC  +   P  G       
Sbjct: 392 VKKVAGGIKLQGSPSSPHKDLPSLIKYHKRHRGGLTTTLKVPCPREIRAPDIGYAVK--- 448

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR--------ESLSSYISLAEDPLDDA 259
                   W+    +++  +    G+   + +G          ++L S  + AE+ L +A
Sbjct: 449 ------DKWEVDRDTIVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSAEEFLQEA 502


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  179 bits (454), Expect = 7e-44,   Method: Composition-based stats.
 Identities = 65/261 (24%), Positives = 114/261 (43%), Gaps = 31/261 (11%)

Query: 7   RGKTSSPSPSSSGPDQEPVS-MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-ED 64
           R K        + P QEPV    P   KVTAV    +    ++ L L+ G+   I + E+
Sbjct: 88  RIKEEKRRKGPATPKQEPVKCFIPINTKVTAV--YDYQPKSKSELQLKQGDVFVITNSEN 145

Query: 65  GDWWTVQSE-VSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
            +WW  Q    S     +PS YV K+    +  + +  + R  AE  L       G+FL+
Sbjct: 146 ENWWEAQPVGNSDIVGWVPSNYVVKLNSLDSEPYYHGRIPRTTAEFFL--SNGINGSFLV 203

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RESQ+  G +++S+R        ++ HYRI R D G ++I+    F ++  LV+ Y + +
Sbjct: 204 RESQSNAGEHTISLRCD-----GKVFHYRISRTDKG-VFIAADRVFSTVQDLVKFYHQQS 257

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           DG+  PLR      +                  S  W+    S++      +G+   + E
Sbjct: 258 DGLVHPLRHAVPKNRQEITAS-----------PSDKWEIDRSSIMMGTRLGAGQYGEVYE 306

Query: 240 GLRESLSSYI---SLAEDPLD 257
            +  + + ++   +L E+ ++
Sbjct: 307 AVLTNKNRHVAVKTLKEEAME 327


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  179 bits (454), Expect = 8e-44,   Method: Composition-based stats.
 Identities = 58/217 (26%), Positives = 94/217 (43%), Gaps = 20/217 (9%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK--VAHGWL 94
           V++  +     + +  + GE   ++    DW  VQSE SG + ++PS  +        W 
Sbjct: 10  VSISEYNPKHNSDIPCKGGEAFYLLERTDDWCYVQSETSGSKGYLPSHLIQLDLTNEPWF 69

Query: 95  YEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDN 154
           +  + R +AE LL       G FLIRES+T +G Y+L++   +  +  +I H+RI   D+
Sbjct: 70  HGNIGRIEAENLLQYS--EPGTFLIRESETIKGSYTLTMIQIKDGT-KQISHFRI-NYDD 125

Query: 155 GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSL 214
           G  +I+    F  LH L++HY + +DG+ C L  P              P P        
Sbjct: 126 GKYFITSARRFLGLHQLIQHYMQNSDGLACNLVYP-------------QPKPSIEYMELD 172

Query: 215 NWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYIS 250
            W+     L       SG    + +G L  S +  I 
Sbjct: 173 VWEIDRGRLKLETKLGSGGFGDVWKGTLDGSFTVAIK 209


>UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RNL0_TETNG
          Length = 509

 Score =  179 bits (454), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 65/249 (26%), Positives = 95/249 (38%), Gaps = 75/249 (30%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV--- 89
              +AL  + A  +  LS R GE   II+  +GDWW  +S  +G   ++PS YVA V   
Sbjct: 4   TLFIALYDYDARTEDDLSFRKGEKFHIINNTEGDWWEARSLDTGNSGYIPSNYVAPVDSI 63

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR----------------------- 125
            A  W +  + R+ AE  LL  GN  G FLIRES+T                        
Sbjct: 64  QAEEWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYVGYT 123

Query: 126 --------RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP--RLTFPSLHALVEHY 175
                    G YSLS+R       D ++HY+I++LDNG  YI+   +   P L  L    
Sbjct: 124 SVPLHSRFPGAYSLSIRDWDDNKGDHVKHYKIRKLDNGGYYITTSCKRGMPKLADL---- 179

Query: 176 SELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEAS 235
                                           +V T  + W+    SL  ++   +G+  
Sbjct: 180 --------------------------------SVKTKDM-WEIPRESLQLIKKLGNGQFG 206

Query: 236 LLSEGLRES 244
            +  G+   
Sbjct: 207 EVWMGMWNG 215


>UniRef50_B7Z4J2 cDNA FLJ50391, highly similar to SRC-like-adapter n=2 Tax=Homo
           sapiens RepID=B7Z4J2_HUMAN
          Length = 249

 Score =  179 bits (453), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 74/251 (29%), Positives = 115/251 (45%), Gaps = 53/251 (21%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           + +  +   S+  P + P+             L  +P+ + +    R GE L +IS++G 
Sbjct: 15  KKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGG 74

Query: 67  WWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
           WW   S  +GRE ++P + VA+V HGWL+EGL R+KAEELL LP    G+F+IRES+T+ 
Sbjct: 75  WWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETK- 133

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
                                                             E+ADG+CC L
Sbjct: 134 -------------------------------------------------KEVADGLCCVL 144

Query: 187 REPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDR---SLLFLEAPASGEASLLSEGLRE 243
             PC+ Q       + +  PVT+   +++W+++ R        E P   + SL S GLRE
Sbjct: 145 TTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRE 204

Query: 244 SLSSYISLAED 254
           S++SY+SL  +
Sbjct: 205 SIASYLSLTSE 215


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score =  177 bits (449), Expect = 3e-43,   Method: Composition-based stats.
 Identities = 55/238 (23%), Positives = 90/238 (37%), Gaps = 27/238 (11%)

Query: 21  DQEPVSMQPE-RHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQ-----SEV 74
              P    P+   +   +AL  + A     L+ + G+ + I+ +  +W   Q        
Sbjct: 48  QDRPAPPIPQIEEEDIYIALYDYVARTNKDLTFKKGDTMVILKKGQNWSIAQLLEPNPLY 107

Query: 75  SGREYHMPSVYVAKVA-----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
           S  E  +P+ YV K +       W+++   R +A  LL+ P N  G FL R   T    Y
Sbjct: 108 SVTEGSIPTNYVKKQSSVVSQPSWMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNPNEY 167

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           +LSVR     +   + H +I+++      I     F +L+ LV +Y E        LR P
Sbjct: 168 ALSVR-----NGATVNHIKIEKMGGQGYSIDHHTMFATLNDLVGYYQENMLANDIRLRSP 222

Query: 190 CVLQKLGPLPGKDTPPPVTVPTSS---LNWKKLDRSLLFLEAPASGEASLLSEGLRES 244
           C    +          P T   S      W+   +S+   E    G    + +GL   
Sbjct: 223 CKQVVME--------SPQTAGLSHDLADEWEIDRKSIELKEKLGKGNFGEVYKGLWNG 272


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score =  176 bits (447), Expect = 5e-43,   Method: Composition-based stats.
 Identities = 53/232 (22%), Positives = 102/232 (43%), Gaps = 38/232 (16%)

Query: 21  DQEPVSMQPERH-----KVTAVALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEV 74
            ++P+   P+       +   +AL  +       L L  G    +I++   DWWTV++  
Sbjct: 152 SKKPLPQLPDPKVNADSERIVIALQEYVPSRDTDLPLEKGHEYILINKSNIDWWTVRN-- 209

Query: 75  SGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
                          ++GW  + ++R +A+ELL+  G   GAF++R+S +  G Y++SV 
Sbjct: 210 ---------------SNGWYSKNMNRMQAQELLMREGKE-GAFMVRDS-SHMGVYTVSVF 252

Query: 135 LSRPASWD----RIRHYRIQRLDNGW--LYISPRLTFPSLHALVEHYSELADGICCPLRE 188
              P+       +++HY+I++ + G    Y++    F ++  L+ ++   A G+   LR 
Sbjct: 253 TKAPSQSGEKNPKVKHYQIRQTETGAGPFYLAENYLFNTIPELIHYHQHNAAGLITRLRH 312

Query: 189 PCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           P         P   +   V+ P  +  W+     L   +   SG+  L+ EG
Sbjct: 313 PVS-------PDGSSAQQVSAPFEADQWELNPDELTLGQEIGSGQFGLVLEG 357


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  176 bits (447), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 60/236 (25%), Positives = 95/236 (40%), Gaps = 35/236 (14%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISEDG--DWWTVQSEVSGRE------------YHM 81
            V L    +  + +LSLR G  L ++  +G  +W   +   +G                +
Sbjct: 12  FVVLYPIESAGRNQLSLRKGCQLRVLRYNGTEEWCEAKVLSTGDPSDNAKCAVVGSVGWV 71

Query: 82  PSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           PS Y+        H W +  +SR  AE LL       G+FL+R+S++ RG  S+SVR + 
Sbjct: 72  PSNYITPATSLNMHTWYHGAVSRAAAEYLL--SSGINGSFLVRDSESCRGHLSVSVRFNA 129

Query: 138 PASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGP 197
                 + HYRI     G  YISP   F +L  LV H+S  +DG+   L  P        
Sbjct: 130 S-----VYHYRINVDTAGLFYISPEHRFQTLPELVHHHSYASDGLAAILHYP-------- 176

Query: 198 LPGKDTPPPVTVPTS-SLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLA 252
              K T P V         W+     +   +    G+   + E + +  +  I++ 
Sbjct: 177 -AAKSTKPAVYSMAPDYDEWEIDRSEIHMKQRLGGGQYGDVYEAVWKRYNKTIAVK 231


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score =  176 bits (445), Expect = 8e-43,   Method: Composition-based stats.
 Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 34/261 (13%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPER--HKVTAVALGSFPAGEQARLSLRLGEPL 58
           MG+        + +    G      + Q +    +   VAL +F +  +A LS   GE L
Sbjct: 1   MGNAGLICFPKTSNVDELGTKLNGANTQKQCLSQENIYVALFNFTSNNEAELSFSCGEQL 60

Query: 59  TIIS-EDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNP 113
            ++S  DG WW V+S ++ +  ++P+ YV K      + W    + R  A   LL  G+ 
Sbjct: 61  ELLSISDGSWWKVRSLLTNKIGYIPNNYVEKYDYLKKYDWYTGVMGRSSANLALLSNGSA 120

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVE 173
            G+FL+R+S ++ G Y+LS+      +   ++HY I++  N   YI  +  F +L +LVE
Sbjct: 121 -GSFLVRKSTSKPGDYTLSL-----HNETSLKHYHIKKTKNCTFYIL-KEEFSNLPSLVE 173

Query: 174 HYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGE 233
           HY +++ G+   L++ C  +KL  +P                    ++  L  +    G 
Sbjct: 174 HYKKVSGGLPRTLKDACSQKKLWDIP-------------------HNKITLTKKHLGKGN 214

Query: 234 ASLLSEG-LRESLSSYISLAE 253
             ++ EG L  S++  + + +
Sbjct: 215 FGIVLEGRLFSSVNVAVKVLK 235


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  175 bits (444), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 63/227 (27%), Positives = 102/227 (44%), Gaps = 22/227 (9%)

Query: 38  ALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQS-EVSGR---EYHMPSVYVAK----V 89
           AL +F + +   LS R G+   ++S   DWW+V+  + SGR      +P  Y+A      
Sbjct: 6   ALWAFQSQQGEHLSFREGDLFRVLSRRDDWWSVRRIDASGRVLDSGLVPGNYLAPAESGQ 65

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W +  L+R +A+  LL P N  GAFLIR S+     Y LSVR     S D+++HY++
Sbjct: 66  TQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVR-----SGDQVKHYKV 120

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
            + D    Y+ P   F SL  LV++Y + +     PL  PC    L          P  +
Sbjct: 121 LQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLS--------TPALL 172

Query: 210 PTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAEDP 255
           P  ++ W+   +     E   SG  + +  G  +  +   + + +  
Sbjct: 173 PFPTIGWELPKKEFELEEELGSGCFARVYRGRWKNLIRVAVKILKSA 219



 Score =  133 bits (335), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 8/167 (4%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W Y  ++R KAE+LLL   N  G+FL+R S++    Y++S R     S  ++ H+RIQR
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISAR-----SEGKVFHFRIQR 303

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
              G  ++S R++F +L  L+ +Y      +   L EPC  Q+                 
Sbjct: 304 SSIGAYFVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLLCLQ---RELF 360

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
               W++       L     G    + E L  + +  +++     +D
Sbjct: 361 DMEPWERPREEFRLLRKLGEGHFGEVWEALWSTENRRVAIKTLKQED 407



 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 14/146 (9%)

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSL 168
            P N  GAFLIR S+     Y LSVR     S D+++HY++ + D    Y+ P   F SL
Sbjct: 730 APENSEGAFLIRVSEKDNVGYVLSVR-----SGDQVKHYKVLQTDQNRFYVEPGRRFSSL 784

Query: 169 HALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
             LV++Y + +     PL  PC    L          P  +P  ++ W+   +     E 
Sbjct: 785 AELVDYYQKTSLNNAGPLGNPCKRNTLS--------TPALLPFPTIGWELPKKEFELEEE 836

Query: 229 PASGEASLLSEG-LRESLSSYISLAE 253
             SG  + +  G  +  +   + + +
Sbjct: 837 LGSGCFARVYRGRWKNLIRVAVKILK 862


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  174 bits (442), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 58/239 (24%), Positives = 97/239 (40%), Gaps = 25/239 (10%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV-QSEVSGR--EYHMPSV 84
               +    +AL  F A     LS + G+   I    GDWWT  + ++ GR     +P  
Sbjct: 63  SANNNAAIYMALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTGFVPYN 122

Query: 85  YVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           Y+A+    +  W +  ++R  A   L+   N  G+FL+R S++    Y LSVR    A  
Sbjct: 123 YLARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENA-- 180

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
              +H++I +  +   Y+     F S+  ++EHY      I   L EPC+  K   +P  
Sbjct: 181 ---KHFKIFQTGD-QFYVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVP-- 234

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAEDPLDDA 259
                   P S+  W+             SG  + +  G  +      I + ++  +DA
Sbjct: 235 --------PPSTDEWELPKEEFQLENQLGSGHFADVYSGKWKNHSKVAIKILKN--NDA 283


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  171 bits (433), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 7/146 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R KAEE+L       GAFLIRES++  G +SLSV+       + ++H+++ R  
Sbjct: 61  FFGKIPRAKAEEML-SKQRHDGAFLIRESESAPGDFSLSVKF-----GNDVQHFKVLRDG 114

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++   + F SL+ LV+++   +
Sbjct: 115 AGKYFLWV-VKFNSLNELVDYHRSTS 139


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  171 bits (433), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 7/146 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R KAEE+L       GAFLIRES++  G +SLSV+       + ++H+++ R  
Sbjct: 61  FFGKIPRAKAEEML-SKQRHDGAFLIRESESAPGDFSLSVKF-----GNDVQHFKVLRDG 114

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++   + F SL+ LV+++   +
Sbjct: 115 AGKYFLWV-VKFNSLNELVDYHRSTS 139



 Score = 55.1 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 7/70 (10%)

Query: 21  DQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREY 79
           D E V  QP        AL  F   E   L  R G+ + ++ + D +WW  +    G+  
Sbjct: 150 DIEQVPQQPTY----VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTG 203

Query: 80  HMPSVYVAKV 89
             P  YV  V
Sbjct: 204 MFPRNYVTPV 213


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  164 bits (414), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 67/268 (25%), Positives = 108/268 (40%), Gaps = 26/268 (9%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQP-----ERHKVTAVALGSFPAGEQARLSLRLGE 56
           G  +S  KT +  P+++      V         E       AL S+ A     LS + GE
Sbjct: 19  GLFTSPDKTEAEKPTNTAKQTVNVPNPSRASACEPGSELYKALWSYKARGADELSFQEGE 78

Query: 57  PLTIISEDGDWWTVQSE-----VSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELL 107
              I    G+WWT         V+GR   +P+ ++A+        W +  L+R + E LL
Sbjct: 79  QFRICERQGEWWTALKLGRDGAVTGR-GFVPNHFLARRQTVKEQPWYFGTLNRFETEILL 137

Query: 108 LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPS 167
           L P N  GAFL+R S+     Y LSV     +    ++H +I +  N   Y+    TF S
Sbjct: 138 LAPENDVGAFLVRHSEKDNIGYVLSVLSGDRSR--EVKHIKIHQNQNESFYLDKSQTFQS 195

Query: 168 LHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
           L  LV++Y + +      L++PC      P P        TV     +W+         E
Sbjct: 196 LEKLVDYYWKYSLDGDSFLKQPCR----RPEPKPKDLSHSTV----NDWELPKEEFTLEE 247

Query: 228 APASGEASLLSEG-LRESLSSYISLAED 254
               G  + +  G  +  ++  I + ++
Sbjct: 248 ELGKGFFADVYRGKWKGMVNVAIKILKN 275


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  164 bits (414), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 49/172 (28%), Positives = 77/172 (44%), Gaps = 18/172 (10%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
             H W +  +SR  AE LL       G+FL+RES++  G  S+S+R        R+ HYR
Sbjct: 9   EKHSWYHGPVSRNAAEYLL--SSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYR 61

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I    +G LY+S    F +L  LV H+S +ADG+   L  P         P ++ P    
Sbjct: 62  INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--------APKRNKPTIYG 113

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYI---SLAEDPLD 257
           V  +   W+     +        G+   + EG+ +  S  +   +L ED ++
Sbjct: 114 VSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME 165


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  163 bits (412), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 60/303 (19%), Positives = 110/303 (36%), Gaps = 68/303 (22%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPA----GEQARLSLRLGEPL 58
           + S+    +   P++        S   +      +AL  F        Q+++ +  G+ L
Sbjct: 25  NTSTSWIQNHNPPTNFKGSVAHTSQINQPSDQLLIALFDFTPPNTLENQSQVRVEKGDRL 84

Query: 59  TII--SEDGDWWTVQSEVSGREYHMPSVY------------------------------- 85
            +   S DGDW  V+   +     +P+ Y                               
Sbjct: 85  QLFGYSADGDWSDVECIRTNERGWIPTNYTGRIPVPPNDHSTTLNTGSASGSSLTFQHTS 144

Query: 86  ---------------VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
                          V   +  W +  + R  AE LL       G+FLIRES++  G  +
Sbjct: 145 SHDVSCNGSQGSLARVGLESEKWYHGAIQRSYAEYLLN--SGITGSFLIRESESHPGQLT 202

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           +S+R        +I HYRI R D+   Y+     F S+  LV H+ + +DG+ C L  P 
Sbjct: 203 ISLRYE-----GQIWHYRIHRDDSNMYYVIESNKFTSVSDLVHHHEKHSDGLACTLLYP- 256

Query: 191 VLQKLGPLPGKDTPPPVTVPTSSLNWKKLDR-SLLFLEAPASGEASLLSEGLRESLSSYI 249
                   P +D          S + +++DR  ++      SG+  ++ E + +  +  +
Sbjct: 257 -------APKRDRTSSELRMDPSFDIREIDRTEIVMKHKLGSGQYGVVYEAVWKPYNVLV 309

Query: 250 SLA 252
           ++ 
Sbjct: 310 AVK 312


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  160 bits (404), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 48/143 (33%), Positives = 79/143 (55%), Gaps = 7/143 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + +VAL SF A E   L+   G+ L I++ + D    ++E+ G E  +P  Y+    H W
Sbjct: 1   MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
               +SR+ AEE+L+   N  GAFLIRES++  G +S+SV        D+++H+++ R  
Sbjct: 61  YSGRISRQLAEEILMKR-NHLGAFLIRESESSPGEFSVSVNY-----GDQVQHFKVLREA 114

Query: 154 NGWLYISPRLTFPSLHALVEHYS 176
           +G  ++     F SL+ LV+ Y 
Sbjct: 115 SGKYFLWEE-KFNSLNELVDFYR 136



 Score = 53.5 bits (127), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 18/69 (26%), Positives = 29/69 (42%), Gaps = 3/69 (4%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYH 80
           ++   +        A A   F A + ++LS R G+ + ++   D  WW  +S   GR   
Sbjct: 149 RDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSC--GRVGF 206

Query: 81  MPSVYVAKV 89
            P  YV  V
Sbjct: 207 FPRSYVQPV 215


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  157 bits (397), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 48/146 (32%), Positives = 79/146 (54%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVA   F A  +  LS   G+ L I+S   +W+    E+  +E ++P  ++      W
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKA--ELGSQEGYVPKNFIDIQFPKW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR       D ++H+++ R +
Sbjct: 59  FHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHE-----DDVQHFKVMRDN 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     FPSL+ LV++Y   +
Sbjct: 112 KGNYFLWTE-KFPSLNKLVDYYRTNS 136



 Score = 51.2 bits (121), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 3/70 (4%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYH 80
            +PV +Q       A AL  F A E   L    GE + ++   +  WWT +  +  +   
Sbjct: 262 TDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGL 319

Query: 81  MPSVYVAKVA 90
            P+ YVA + 
Sbjct: 320 FPANYVAPMT 329


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  155 bits (391), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 45/146 (30%), Positives = 76/146 (52%), Gaps = 8/146 (5%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS R  + L I++ + D    ++E+ G+E  +PS Y+    H W
Sbjct: 1   MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            Y  ++R  AE+LL       GAFLIR S++  G +SLSV+       D ++H+++ R  
Sbjct: 61  YYGRITRADAEKLL--SNKHEGAFLIRISESSPGDFSLSVKC-----PDGVQHFKVLRDA 113

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
               ++   + F SL+ LVE++   +
Sbjct: 114 QSKFFLWV-VKFNSLNELVEYHRTAS 138



 Score = 53.5 bits (127), Expect = 8e-06,   Method: Composition-based stats.
 Identities = 21/87 (24%), Positives = 34/87 (39%), Gaps = 3/87 (3%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           SL+   +    +  S   D +   M PE  ++   AL  F   E   L  R G+ +T+  
Sbjct: 126 SLNELVEYHRTASVSRSQDVKLRDMIPE--EMLVQALYDFVPQESGELDFRRGDVITVTD 183

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKV 89
              + W    E+  R+   P+ YV   
Sbjct: 184 RSDENWW-NGEIGNRKGIFPATYVTPY 209


>UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59F39_HUMAN
          Length = 376

 Score =  154 bits (389), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 50/188 (26%), Positives = 95/188 (50%), Gaps = 17/188 (9%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISED 64
            ++  +  P P +   ++ P+  +PE  +   +AL  +   +   L+LR  E   ++   
Sbjct: 193 PTKNASKKPLPPTPEDNRRPL-WEPE--ETVVIALYDYQTNDPQELALRRNEEYCLLDSS 249

Query: 65  G-DWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAF 117
              WW VQ + +G E ++PS Y+ + +      + W  + +SR+KAE+LLL  G   GAF
Sbjct: 250 EIHWWRVQ-DRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAF 307

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDR--IRHYRIQRLDNG--WLYISPRLTFPSLHALVE 173
           ++R+S+T  G Y++SV      S +   I+HY I+  ++     Y++ +  F S+  L+ 
Sbjct: 308 MVRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLIN 366

Query: 174 HYSELADG 181
           ++     G
Sbjct: 367 YHQHNGGG 374


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score =  152 bits (384), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ L I+S + DW+    E++G+E ++P  Y+      W
Sbjct: 1   MEAQGKYDFMATGDTELSFRKGDILKILSPEDDWFKA--EMNGQEGYVPQNYIEIQTPRW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEELL   G   G F+IR  Q+  G +S+SVR         ++H+++ R  
Sbjct: 59  FQENASRSAAEELLRHKG--VGEFVIRGCQSSPGEFSISVRHESD-----VQHFKVMRDS 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     F SL+ LV+ Y   +
Sbjct: 112 RGQYFLWSE-KFTSLNKLVDFYRTSS 136



 Score = 54.7 bits (130), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 19/85 (22%), Positives = 33/85 (38%), Gaps = 7/85 (8%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVT------AVALGSFPAGEQARLSLRLGEPLTIISED 64
           SSP   +  P +   +M P +            AL  F A E   LS   G+ + ++   
Sbjct: 242 SSPVSGAQPPRRTCETMPPPQFLCVLQRADLVKALYDFTAEEDDELSFCAGDVIDVLDRS 301

Query: 65  GDWWTVQSEVSGREYHMPSVYVAKV 89
            + W  +  + G     P+ Y A++
Sbjct: 302 DESWW-KGRLRGNSGLFPANYTAQL 325


>UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E29F
          Length = 466

 Score =  152 bits (383), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 66/236 (27%), Positives = 88/236 (37%), Gaps = 70/236 (29%)

Query: 18  SGPDQEPVSMQPERHKV------TAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTV 70
                 P+   PE            VAL  + A     LS R GE L I+++  GDWW  
Sbjct: 45  PEVRNGPMPPVPEPDGTNNSNAKMFVALYDYDARTDEDLSFRKGELLEILNDTQGDWWLA 104

Query: 71  QSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
           +S                          S   +E+ LLLP N  GAFLIR+S++RR  YS
Sbjct: 105 RS--------------------------SSSDSEKKLLLPENEHGAFLIRDSESRRNDYS 138

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           LSVR       D ++HYRI      W++ S +  F +L  LVEH                
Sbjct: 139 LSVRD-----GDTVKHYRIDIR-RRWIFCS-KNNFRTLQELVEH---------------- 175

Query: 191 VLQKLGPLPGKDTPPPVTVPTSS---LNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
                          PVT   S      W+   +SL F+     G+   + EGL  
Sbjct: 176 -----------TIEKPVTGGLSHSTRDQWEIDRKSLKFVRKLGHGQFGDVWEGLWN 220


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score =  150 bits (378), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ L I+S + DW+    E++G+E ++P  Y+      W
Sbjct: 1   MEAQGKYDFMATGDTELSFRKGDILKILSPEDDWFKA--EMNGQEGYVPQNYIEIQTPRW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEELL   G   G F+IR  Q+  G +S+SVR         ++H+++ R  
Sbjct: 59  FQENASRSAAEELLRHKG--VGEFVIRGCQSSPGEFSISVRHESD-----VQHFKVMRDS 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     F SL+ LV+ Y   +
Sbjct: 112 RGQYFLWSE-KFTSLNKLVDFYRTSS 136



 Score = 58.1 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 18/76 (23%), Positives = 30/76 (39%), Gaps = 1/76 (1%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV 70
           SSP   +  P +   +M P +      AL  F A E   LS   G+ + ++    + W  
Sbjct: 209 SSPVSGAQPPRRTCETMPPPQRADLVKALYDFTAEEDDELSFCAGDVIDVLDRSDESWW- 267

Query: 71  QSEVSGREYHMPSVYV 86
           +  + G     P+ Y 
Sbjct: 268 KGRLRGNSGLFPANYT 283


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score =  149 bits (377), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 45/148 (30%), Positives = 75/148 (50%), Gaps = 10/148 (6%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           H + A+A   F A  +  LS + G+ L I+S   +W+    E+   E ++P  ++     
Sbjct: 14  HNMEAIAKFDFTASGEDELSFQAGDVLKILSSQEEWYKA--ELRSHEGYVPKNFIDFHVP 71

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W  E +SR +AE LL+  G   G F++R SQ   G +S+SVR       D ++H+++ R
Sbjct: 72  HWFDEKISRHEAENLLMSKG--VGCFVVRASQNSHGDFSISVRHE-----DDVQHFKVMR 124

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELA 179
              G  Y+     F SL+ LV++Y   +
Sbjct: 125 DSKGSYYLWTE-KFHSLNKLVDYYKTSS 151



 Score = 53.1 bits (126), Expect = 9e-06,   Method: Composition-based stats.
 Identities = 19/69 (27%), Positives = 30/69 (43%), Gaps = 4/69 (5%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYH 80
            +P+  Q +R  +   AL  F A E   L  R G+ L ++   +  WW  +  + G    
Sbjct: 244 TDPLHQQAQRT-LWVRALYDFDAMEHDELGFRSGDILEVLDSSNPSWW--KGRLRGELGL 300

Query: 81  MPSVYVAKV 89
            P+ YV  V
Sbjct: 301 FPANYVTPV 309


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  147 bits (371), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 52/246 (21%), Positives = 81/246 (32%), Gaps = 29/246 (11%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEV 74
              P    +  +        +        +   L+ R G+ +TI+   E+  W+ V+   
Sbjct: 34  HPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHT 93

Query: 75  SGREY----------HMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQT 124
           SG+E              S         W +  +S ++A + L  P    G FL+RES  
Sbjct: 94  SGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPP--EDGLFLVRESAR 151

Query: 125 RRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC 184
             G Y L V   R      + HYR+   D G L I   + F +L  +VEHYS+    IC 
Sbjct: 152 HPGDYVLCVSFGRD-----VIHYRVLHRD-GHLTIDEAVFFCNLMDMVEHYSKDKGAICT 205

Query: 185 PLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES 244
            L  P                      +   W    + L        GE   + +G    
Sbjct: 206 KLVRPKRKHGTK---------SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG 256

Query: 245 LSSYIS 250
               + 
Sbjct: 257 QKVAVK 262


>UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n=3 Tax=Schistosoma
           RepID=C1LZF7_SCHMA
          Length = 234

 Score =  146 bits (369), Expect = 6e-34,   Method: Composition-based stats.
 Identities = 54/224 (24%), Positives = 94/224 (41%), Gaps = 32/224 (14%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A A   F A  +  L  + G  L I+   +D +W+  + E  GR   +P  Y+    H
Sbjct: 1   MEAEASYDFVANAEDELGFKKGSLLKILCVEDDPNWYLAEQE--GRTGLIPCNYITMRPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AEE L            P GAF++R+S+     +SLSV+         +
Sbjct: 59  PWYIRHCSRMEAEERLQEIDQETAQHLQPDGAFILRQSEADGKGFSLSVK-----QGCEV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
            H+++ + + G  +      F S++ L++H+ + +            + +   L   D  
Sbjct: 114 LHFKVLQDEAGKYFFW-LSKFDSINQLIDHHRKTS------------ISRNRLLTLVDLV 160

Query: 205 PPVTVPTSSLNWKKLDRSL--LFLEAPASGEASLLSEGLRESLS 246
           P    PT+   ++ LDR +     E   +GE SL    + E +S
Sbjct: 161 PSKRFPTNVRKYQ-LDRVIARFDFETKGAGELSLHRGDVIEVIS 203



 Score = 52.8 bits (125), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 26/71 (36%)

Query: 20  PDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREY 79
           P +   +   +      +A   F       LSL  G+ + +IS + + W       GR  
Sbjct: 161 PSKRFPTNVRKYQLDRVIARFDFETKGAGELSLHRGDVIEVISRNDENWWRGRTSDGRCG 220

Query: 80  HMPSVYVAKVA 90
             PS +V  + 
Sbjct: 221 LFPSNFVDDLP 231


>UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE
          Length = 249

 Score =  146 bits (368), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 44/146 (30%), Positives = 74/146 (50%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ + I+  + DW+    E++G E  +P  Y+      W
Sbjct: 1   MEATGKYDFSATAGDELSFRKGDVIKILGTNDDWFRA--EINGMEGFVPRNYIVTTFPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR+ A++ L+    P GAF+IR SQ+  G +S+SVR         ++H+++ R  
Sbjct: 59  YKENTSRQSAQDELMCQ--PIGAFIIRGSQSSPGDFSISVRHEND-----VQHFKVMRDR 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  Y+   + F SL+ LV++Y+  +
Sbjct: 112 QGRYYLWSEM-FTSLNKLVDYYTHNS 136



 Score = 53.9 bits (128), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 16/83 (19%), Positives = 33/83 (39%), Gaps = 3/83 (3%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           R    S +P  + P Q  +   P+   +   A+  F A +   L+ + G+ + ++ +   
Sbjct: 170 RQDYRSLAPPVARPSQPSLP--PQVSALHVRAMYDFTAEDADELNFQAGDVIEVLDQSDR 227

Query: 67  WWTVQSEVSGREYHMPSVYVAKV 89
            W  +  + GR    P  Y   +
Sbjct: 228 SWW-KGVLRGRTGLFPVNYTNPL 249


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score =  145 bits (367), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 44/154 (28%), Positives = 70/154 (45%), Gaps = 15/154 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +   SR+ AE+ L+  G   G F++R+     G + LSVR + P   D ++HYRI ++
Sbjct: 7   WDFGMCSRQDAEKKLMAIGINKGQFIVRDRD--PGTFELSVRDNNPQKGDHVKHYRIWKM 64

Query: 153 DNG-WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
           D G   +I     FP++  LV HY   +DG+CC L E C  +            P T+  
Sbjct: 65  DGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKEN-----------PNTIGL 113

Query: 212 SSLNWKKLDRSL-LFLEAPASGEASLLSEGLRES 244
               W+   +SL         G+   + +G+   
Sbjct: 114 GKDKWETPRKSLGQMNRRLGEGKFGEVWQGVWNG 147


>UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo salar
           RepID=B5X487_SALSA
          Length = 289

 Score =  145 bits (367), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A  +  LS R G+ L I+    +W+    E+ G+E  +P  Y+ +    W
Sbjct: 1   MEARGKYEFNATAEDELSFRKGDILKILGSQDEWFKA--ELHGQEGFVPQNYIERQTPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEELL+      G FLIR SQ+  G +S+SVR         ++H+++ +  
Sbjct: 59  FKETASRSSAEELLM--SREVGGFLIRGSQSSPGEFSISVRHEFD-----VQHFKVMKDS 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     F SL+ LV+ Y   +
Sbjct: 112 KGHYFLWSE-KFTSLNKLVDFYKNTS 136



 Score = 52.0 bits (123), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 19/81 (23%), Positives = 35/81 (43%), Gaps = 4/81 (4%)

Query: 11  SSPSPSSSGPDQEPVSMQ-PERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWW 68
           ++P  S   P +   +M   +R  +   A+ +F A E   L  R G+ + I+   D  WW
Sbjct: 211 NTPLTSLQAPQRTSETMPHQQRAVIQVKAVYNFTAEEGDELGFRAGDVIDILDHSDPSWW 270

Query: 69  TVQSEVSGREYHMPSVYVAKV 89
             +  + G+    P+ Y   +
Sbjct: 271 --KGRLRGKSGLFPANYTTPL 289


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score =  145 bits (367), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 48/172 (27%), Positives = 77/172 (44%), Gaps = 18/172 (10%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + AVA   F   E   L    G  L I+   ED +W+  +  +  +E  +P+ Y++   H
Sbjct: 1   MEAVANYPFTPTEPDELGFEKGSTLYIVGMEEDPNWYKAR--LGNQEGMVPANYISLYPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AE  LL           P GAF++R+S+   G +S+SV+         +
Sbjct: 59  PWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVK-----EGSSV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHY-SELADGICCPLREPCVLQKL 195
            H+RI     G  YI     F S++AL++++  +   G+   L   CV  K 
Sbjct: 114 LHFRIFFDPKGKYYIWT-NKFDSINALIDYHRHQTIYGVKALLLRDCVSSKT 164



 Score = 57.4 bits (137), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 21/84 (25%), Positives = 34/84 (40%), Gaps = 7/84 (8%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWT 69
           +   P+    D  P  +         VA   F A  Q  +S R G+ L ++  ED +WW 
Sbjct: 202 TKEHPAQMNLDLPPGVVFTNLSGRQCVAKFDFNAEFQEEMSFRQGDRLRLLGEEDENWWF 261

Query: 70  VQ---SEVSGR---EYHMPSVYVA 87
            +      SG+   +  +P+ YV 
Sbjct: 262 AELITHASSGQPTPQGLIPANYVK 285


>UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE
          Length = 284

 Score =  145 bits (365), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F    +  LS R G+ L I+    DW+    E+ G E ++P  YV +    W
Sbjct: 1   MEARGKYDFSGTAEDELSFRKGDTLKILGSQDDWFKA--ELHGHEGYVPKNYVDRQIPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEE L+      GAFLIR SQ+  G +S+SVR         ++H+++ +  
Sbjct: 59  FKESASRGSAEETLM--SREVGAFLIRGSQSSPGDFSISVRHDYD-----VQHFKVMKDK 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
           +G  Y+     F SL+ LV+ Y   +
Sbjct: 112 SGHYYLWTE-KFTSLNKLVDFYKTTS 136



 Score = 55.1 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 17/89 (19%), Positives = 33/89 (37%), Gaps = 2/89 (2%)

Query: 2   GSLSSRGKT-SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           GS+  +  T      +S  P +   +    R  +   A+  F A E   L    G+ + +
Sbjct: 197 GSVEEKSNTLGHQGKNSPAPRRTSETAPAPRSTIQVRAIYDFTAEEDDELGFNSGDIIEV 256

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKV 89
           +      W  +  + GR    P+ Y  ++
Sbjct: 257 LDRSDASWW-KGRLRGRSGLFPANYTEQI 284


>UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicum
           RepID=Q5DBN4_SCHJA
          Length = 312

 Score =  144 bits (363), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 18/172 (10%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A+A  +F   E   L    G  L I+   ED +W+  +     +E  +P+ Y++   H
Sbjct: 1   MEAIANYAFSPTEPDELGFEKGSTLCIVGMEEDPNWYKAR--QGNQEGMVPANYISLCPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AE  LL           P GAF++R+S+   G +S+SV+         +
Sbjct: 59  PWYIPKCSRREAEARLLETDPNTHRDVQPDGAFVLRQSENDPGHFSISVK-----EGSSV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHY-SELADGICCPLREPCVLQKL 195
            H+RI    +G  YI     F S++AL++++  +   GI   L   CV  K+
Sbjct: 114 LHFRIFFDPSGKYYIWT-NKFSSINALIDYHRHQTIYGIKALLLRDCVSSKI 164



 Score = 53.9 bits (128), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 17/77 (22%), Positives = 29/77 (37%), Gaps = 7/77 (9%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQ------SEVS 75
            P  M         VA   F A  +  +S R G+ L ++  ED +WW  +          
Sbjct: 213 PPGVMCTNLSGRHCVAKFDFDAEFREEMSFRRGDRLRLLGEEDENWWFAELLTHAPGSQP 272

Query: 76  GREYHMPSVYVAKVAHG 92
                +P+ YV  +++ 
Sbjct: 273 SSHGLIPANYVELLSNS 289


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  141 bits (356), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 47/211 (22%), Positives = 81/211 (38%), Gaps = 42/211 (19%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G+++    ++         D        E      VAL SF +     LS   G+ L I+
Sbjct: 189 GNVAGWFPSNYTQEEGDADDTLHTYAMAENVLDIVVALYSFSSTNDQELSFEKGDRLEIL 248

Query: 62  SE---DGDWWTVQSEVSGREYHMPSVYVAKVAH--------------------------- 91
                D +W+  ++   G+   +P  Y+ +++                            
Sbjct: 249 DRPPSDPEWYKARN-AQGQVGLVPRNYLQELSEYLTQPFLDRKQEPMERSQVAMGDKPHL 307

Query: 92  ---GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               W Y  ++R   + LL   G+  G FLIR+S+T  G YS+S++     +  R +H+R
Sbjct: 308 VDKPWYYGSITRYMCDNLLNQRGH-DGDFLIRDSETNVGDYSVSLK-----APGRNKHFR 361

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           +     G LY   +  F +L  LV+HY    
Sbjct: 362 VHV--EGALYCIGQRKFHTLDQLVDHYQRAP 390



 Score = 63.9 bits (154), Expect = 5e-09,   Method: Composition-based stats.
 Identities = 26/101 (25%), Positives = 39/101 (38%), Gaps = 10/101 (9%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQP--ERHKVT-------AVALGSFPAGEQARLSLR 53
           S+    + S  S S+ G    P +M     RH  T        VA   + A     L LR
Sbjct: 6   SVRGMPEPSWQSKSNFGAKSTPHAMAAPNIRHGKTGQDDICHVVAKYDYAAQGPQELDLR 65

Query: 54  LGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWL 94
             E   ++ +   WW VQ+  + +  ++PS YV K      
Sbjct: 66  KNERYLLLDDSKHWWKVQNSRN-QAGYVPSNYVKKEKPSLF 105



 Score = 54.7 bits (130), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 21/94 (22%), Positives = 35/94 (37%), Gaps = 9/94 (9%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKV--------TAVALGSFPAGEQARLSLRLGEPL 58
           +G  S   PS++ P +   S    R +         TAV   ++ A +   LSL  G  +
Sbjct: 114 KGAGSKTLPSNNSPSRTVESPSMARRQAADPSEAIGTAVVKYNYQAQQPDELSLVKGSRI 173

Query: 59  TIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
            I+ +  D W  + +        PS Y  +    
Sbjct: 174 LILEKSNDGWW-RGQSGNVAGWFPSNYTQEEGDA 206


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score =  141 bits (356), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 34/166 (20%), Positives = 70/166 (42%), Gaps = 12/166 (7%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW-DRIRHYRI 149
           + W    +SR ++E+LL   G   GAF++R S ++ G Y++S+           ++HY +
Sbjct: 294 YDWFAGNISRSQSEQLLRQKGKE-GAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHYHV 351

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
                  LY++    F S+  L+ ++   + G+   LR P           K    P +V
Sbjct: 352 HTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS--------TKANKVPDSV 403

Query: 210 PTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
              +  W+     +  L+   SG+  ++  G  +      + + ++
Sbjct: 404 SLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE 449


>UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow
           tyrosine kinase gene in chromosome X protein)
           (Epithelial and endothelial tyrosine kinase) (ETK)
           (NTK38). n=2 Tax=Gallus gallus RepID=UPI0000ECD739
          Length = 633

 Score =  141 bits (355), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 44/255 (17%), Positives = 91/255 (35%), Gaps = 19/255 (7%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHK---VTAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
           K   P P +    +  +      +K     AVA  ++     + + +       ++ E+ 
Sbjct: 160 KPLPPVPQTLKLRRRSLPQVVSSNKGILNMAVAQCNYEPSGNSAIRVVKSNKYHVLQEED 219

Query: 66  D-WWTVQSEVSGREYHMPSVYVA---KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRE 121
             WW V+    G E  +PS  +A   K    W   G+SR ++E+LL       G F +  
Sbjct: 220 FAWWKVRDLE-GNEGFVPSTCLAGQKKNQEIWYVAGISRAQSEQLLHQSPKISG-FTVAL 277

Query: 122 SQ-TRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           +Q +R     +            ++HY + +      Y++    F ++  L+ ++   + 
Sbjct: 278 AQMSRLYTSKMKSPFYGENKKGTVKHYHVHKTPENKYYLTENHCFETIPKLINYHQHNSA 337

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           G+   LR     Q            P T    +  W+     ++ L    SG+   +  G
Sbjct: 338 GMVPRLRHVVSTQI--------NKVPATASLGNGIWELKREEIVPLRELGSGQFGAVHLG 389

Query: 241 -LRESLSSYISLAED 254
             +      + + ++
Sbjct: 390 KWKGLYDVAVKMIKE 404


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score =  140 bits (354), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 49/250 (19%), Positives = 81/250 (32%), Gaps = 56/250 (22%)

Query: 52  LRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVA------------------- 90
            R  + + I+  + D  W+  ++     E  + +  V +V                    
Sbjct: 69  FRKDDHVRILGNTSDPAWYRARNASH-EEGLVHADCVVRVNGQSYENGIVRMRASGCDPG 127

Query: 91  ------------------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
                               W +  +SRE  E+LL   G P G FL+RES    G ++L 
Sbjct: 128 AASTASSTSSHHSSVANNQPWFHSMISRENTEKLLR--GKPDGTFLVRESTNFPGDFTLC 185

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP--C 190
           +     A   ++ HYRI++   G L       F +L  LV HY   ADG+C  L  P  C
Sbjct: 186 M-----AYHGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIIC 240

Query: 191 VLQKLGPLPGKDTPPPVTVP-------TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
                            TV                    +   +    GE   +  G  +
Sbjct: 241 ETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVIPSNEIDVGDTIGHGEFGDVRLGTYK 300

Query: 244 SLSSYISLAE 253
           +    + +++
Sbjct: 301 NRKVALKVSK 310


>UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYM5_SCHMA
          Length = 670

 Score =  139 bits (350), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 54/270 (20%), Positives = 88/270 (32%), Gaps = 60/270 (22%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKVA 90
                A  +F   +   L     E L II+  +D +W   ++   G    +P  YV + A
Sbjct: 14  GDVVKANYTFKKDKNEDLPFSKNETLEIINIGKDPNWAHAKN-AFGETGLIPLNYVQRKA 72

Query: 91  --------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSV--------- 133
                   H W +  +SR ++E LL   G+P G+FLIRES    G  +L V         
Sbjct: 73  DILENLKDHCWYHGRISRAESESLL--SGSPVGSFLIRESDLYSGGLTLCVVGPACAVGS 130

Query: 134 ---------RLSRPASWDRIRHYRIQRLDNG-------------------WLYISPRLTF 165
                     ++ P +   ++HYRI R                          +     F
Sbjct: 131 PDTTEHQNSTVTPPNTMTNVQHYRIVRRPFKATPSNQHSEYSTPLICSKIHYTLDETDWF 190

Query: 166 PSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF 225
            SL  LV+ YSE   G+ C L  P    +   L                 +    + +  
Sbjct: 191 SSLLELVQFYSEPKRGLVCALLHPVPDMQRKRLSELQK----------FGYLIFRKEIAL 240

Query: 226 LEAPASGEASLLSEGLRESLSSYISLAEDP 255
            +    GE   + +         + + +  
Sbjct: 241 GDRIGRGEFGEVLKATYRGRQVAVKIYKKT 270


>UniRef50_Q4T2Z8 Chromosome 18 SCAF10147, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4T2Z8_TETNG
          Length = 279

 Score =  138 bits (348), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 54/212 (25%), Positives = 91/212 (42%), Gaps = 35/212 (16%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVAL SFPA E   L+ + G+ + +   + D     +E+ G+  ++P  Y++ + + W
Sbjct: 1   MEAVALFSFPAAEADELTFQEGDVIKVTEMEDDSGWFTAEIQGKRGYIPQNYISLLPYPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS------------- 140
               +SR +AE+ L       G FL+RES++  G +S+SV                    
Sbjct: 61  FVGRVSRLEAEKRLRWQ--DPGVFLVRESESAPGEFSVSVSFVFNWHKTNLSLSSGGHSS 118

Query: 141 --------------WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA---DGIC 183
                          +R+ H+R+  L+ G  Y     +F SL+ LV+ Y   +   D + 
Sbjct: 119 DLRAWVLPHDIVSYGNRVEHFRV--LEGGGQYCIWEESFCSLNRLVDFYRTHSIAMDKVV 176

Query: 184 CPLREPCVLQKLGPLPGKDTPPPVTVPTSSLN 215
           C LR+P    +  P       P  T    SL+
Sbjct: 177 C-LRDPPSSPQRQPGCNPYPNPYKTCSRESLH 207


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score =  138 bits (348), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 49/158 (31%), Positives = 72/158 (45%), Gaps = 27/158 (17%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--S 62
           +S+    +P P    P                VAL  F AG + +LSL+ GE + I+  +
Sbjct: 174 TSKENLLAPGPEEDDPQ-------------LFVALYDFQAGGENQLSLKKGEQVRILSYN 220

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
           + G+W    S+ SG    +PS YV        H W +  +SR  AE LL       G+FL
Sbjct: 221 KSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLL--SSGINGSFL 277

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW 156
           +RES++  G  S+S+R        R+ HYRI    +G 
Sbjct: 278 VRESESSPGQRSISLRYE-----GRVYHYRISEDPDGK 310


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  138 bits (348), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 44/166 (26%), Positives = 70/166 (42%), Gaps = 19/166 (11%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           A  W +  + RE+AE LL       G FL+RES    G Y+L V  +     +++ HYRI
Sbjct: 375 AMPWFHGRIKREEAENLL--KPREDGLFLVRESTNFPGDYTLCVCFN-----EKVEHYRI 427

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
           +  +N  L I     F +L  LVEHY+  +DG+C  L +    ++      +D       
Sbjct: 428 KYAEN-KLTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEEFCVKDFQDN------ 480

Query: 210 PTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDP 255
                 W+     L   E    GE   +  G+ +     + + +D 
Sbjct: 481 -----GWEIKMEDLQLKENIGKGEFGDVMLGILKGEKVAVKVLKDA 521


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score =  137 bits (346), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 48/187 (25%), Positives = 83/187 (44%), Gaps = 12/187 (6%)

Query: 68  WTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG 127
           + V+++    ++ + S+Y   +A+ W +  ++REKAEELL       G FL+RES    G
Sbjct: 11  YQVRNDY---QFSLVSIYELDLAN-WFFGKITREKAEELL--TPREVGLFLVRESTNFPG 64

Query: 128 CYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            Y+L V    P +  ++ HYR+   ++  + +     FP+L  L++HY   ADG+C  L+
Sbjct: 65  DYTLCVV--SPQNNKKVEHYRVISTNDNRVTVDEDAFFPNLIELIKHYERDADGLCTMLK 122

Query: 188 EPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSS 247
           +P   +    L                 W      + F E    GE   + +G+    + 
Sbjct: 123 KPLKKKTEMVLQSAIFK----ESFQKEGWAVPIEDVEFKELIGKGEFGDVYKGVWAKKTV 178

Query: 248 YISLAED 254
            I    D
Sbjct: 179 AIKKLRD 185


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  136 bits (343), Expect = 5e-31,   Method: Composition-based stats.
 Identities = 59/208 (28%), Positives = 91/208 (43%), Gaps = 40/208 (19%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAV-ALGSFPAGEQARLSLRLGEPLTI 60
           GS+ +R   ++  P+       P  +Q  R     V AL SF A     LS + GE L I
Sbjct: 181 GSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEVVVALYSFDASSSEELSFKKGERLEI 240

Query: 61  IS---EDGDWWTVQSEVSGREYHMPSVYVA--------------------------KVAH 91
           +     D DWW  ++  SG    +P  Y+                               
Sbjct: 241 VDHPEHDPDWWMARN-ASGTTGLVPRNYIEVVNDSSSSKASHQDFAPQYSGNGEIPMEQQ 299

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +SRE+AE+LLL      G FL+R+S++  G  S+S+R       +R +H+++Q 
Sbjct: 300 PWYFGRISRERAEDLLLHG--REGEFLVRDSESNPGDLSISMR-----GIERNKHFKVQN 352

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELA 179
           +D G L I  R TF  ++AL+ HY+   
Sbjct: 353 VD-GLLKIGNR-TFVDMNALINHYTTSP 378



 Score = 62.4 bits (150), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 1/59 (1%)

Query: 32 HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVA 90
           +   V    + A E+  L+++  E L ++ +  +WW V ++ S     +PS YV K +
Sbjct: 2  SEDYVVVKYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMND-SNSVGFVPSNYVRKES 59



 Score = 49.7 bits (117), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 16/70 (22%), Positives = 28/70 (40%), Gaps = 2/70 (2%)

Query: 20  PDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREY 79
           P    + M   + K  AV   ++    +  L L  G+ + ++ +  D W      +G   
Sbjct: 105 PSSNKIPMMSSKTK--AVVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVG 162

Query: 80  HMPSVYVAKV 89
             PS YV +V
Sbjct: 163 WFPSNYVEEV 172


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  136 bits (342), Expect = 8e-31,   Method: Composition-based stats.
 Identities = 41/186 (22%), Positives = 72/186 (38%), Gaps = 11/186 (5%)

Query: 74  VSGREYHMPSVYVAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
            +G++  +   YVA        W +  ++RE  E++L   G   G FL+R+S    G Y+
Sbjct: 24  TNGKQTSVDRRYVANNEQHPKLWYHGNITREHTEKIL--SGQADGTFLVRDSTNFPGDYT 81

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           L +  +      ++ HYRI +L NG L      TF +L  L+ HY   ADG+C  L  P 
Sbjct: 82  LCMAFN-----GKVEHYRIYQL-NGILTCDHEETFDNLTQLIAHYKRDADGLCHRLITPV 135

Query: 191 VLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYIS 250
           +          ++           +       +   +    GE   +  G  +     + 
Sbjct: 136 ISDDYRITRDNESLEERIRFFREASLIISRSEIRLGDIIGHGEFGDVLLGDYDGQRVAVK 195

Query: 251 LAEDPL 256
           + +   
Sbjct: 196 VLKRSE 201


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score =  135 bits (341), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 15/166 (9%)

Query: 34  VTAVALGSFPAG--EQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA-KVA 90
           +  VAL  F     EQ  L+ + GE L +I  +   W +  +   ++  +P  Y+  + +
Sbjct: 1   MEYVALFDFSPSKEEQDELAFKKGEVLKVIKREDRHWLLAHQG-AKQGLVPENYLKIEKS 59

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR--GCYSLSVRLSRPASWDRIRHYR 148
           H W    +SR+ AEE L+   +  GAF+IR+S++    G +SLSV+       D+++H++
Sbjct: 60  HPWYVGKISRKVAEEYLMSMPS-DGAFMIRDSESNPDSGNFSLSVKFR-----DQVQHFK 113

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSEL--ADGICCPLREPCVL 192
           I     G  ++   + F S++ LV+++ +   +      L EPCV 
Sbjct: 114 ILTDLAGKYFLWV-VKFTSINDLVDYHKDNSVSRTQEIVLNEPCVP 158



 Score = 46.2 bits (108), Expect = 0.001,   Method: Composition-based stats.
 Identities = 17/79 (21%), Positives = 34/79 (43%), Gaps = 4/79 (5%)

Query: 15  PSSSGPDQEPVSMQPERHKVTAV-ALGSFPAGEQARLSLRLGEPLTIISE-DGDWW--TV 70
           P      +   +MQ  R ++  V AL +F + +   L+ +  + +T+      DWW   +
Sbjct: 158 PIEDANQRPQPAMQQSRERLQQVKALYNFESDDAQELTFKQNDVITLTGRPHADWWEGEI 217

Query: 71  QSEVSGREYHMPSVYVAKV 89
           ++    R    P  YV ++
Sbjct: 218 RAPTGTRRGIFPKNYVKEL 236


>UniRef50_P78453 Tyrosine kinase (Fragment) n=11 Tax=Euteleostomi RepID=P78453_HUMAN
          Length = 177

 Score =  134 bits (336), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 40/98 (40%), Positives = 55/98 (56%), Gaps = 5/98 (5%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV--- 89
              +AL  + A  +  L+   GE   I++  +GDWW  +S  SG+   +PS YVA V   
Sbjct: 80  TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSI 139

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
            A  W +  + R+ AE  LL PGNP GAFLIRES+T +
Sbjct: 140 QAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177


>UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C9CC
          Length = 388

 Score =  133 bits (334), Expect = 7e-30,   Method: Composition-based stats.
 Identities = 47/153 (30%), Positives = 72/153 (47%), Gaps = 12/153 (7%)

Query: 93  WLYEGL-SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +E + +R +A+  LL P N  GAFL+ +       Y LS ++ +  +    RHYRI++
Sbjct: 1   WYFENVKTRVEAKRCLLRPENKEGAFLVWKCDENNH-YYLSGKVHKVKNGPHARHYRIKQ 59

Query: 152 LDN-GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
            +N    ++    TF SL  L+E YS+   G+C  L E CV          D P P T+ 
Sbjct: 60  GENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEACVKL--------DQPVPQTLS 111

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
             S   +    SL   +   SGE + + +GL  
Sbjct: 112 FDSKC-EIDRSSLTKQQKLGSGEFADVWQGLWN 143


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  133 bits (334), Expect = 7e-30,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 71/169 (42%), Gaps = 14/169 (8%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V   A  W +  ++R++AE LL       G FL+RES    G Y+L V         ++ 
Sbjct: 472 VKLNAMPWFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQS-----KVE 524

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HYR++ L+N  L I     F +L  LV HY   ADG+C  L + C+ +        ++  
Sbjct: 525 HYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-CLPKLGKQEFCINSKD 582

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                     W   +  L   E+   GE   +  G+  +    + + +D
Sbjct: 583 -----FVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKD 626


>UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=Q9N3S5_CAEEL
          Length = 618

 Score =  132 bits (332), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 58/278 (20%), Positives = 103/278 (37%), Gaps = 41/278 (14%)

Query: 2   GSLSSR--GKTSSPSPSSSGPDQEPVSMQ-----------PERHKVTAVALGSFPAGEQA 48
           G++S      ++   P+ +     PVS              E  +   +    F A    
Sbjct: 96  GNISRHPSATSTKSVPNGASFSPRPVSKTHSHHGSAKCSHSEPEEKMLIVENRFLAQTPK 155

Query: 49  RLSLRLGEPLTIISEDG-DWWTVQSEVSGREYHMPSVYV--AKVAHGWLYEGLSREKAEE 105
            +S+  G+ L +I +   +WW V S+    +  +P  +V  A+    W    +S   AE+
Sbjct: 156 EMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSHVVYAEYREPWFAGNISSILAEQ 215

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRL-- 163
            ++ P  P G+FLIRE  ++   + L VR S   S      YR    +   +  + R   
Sbjct: 216 RVMQPQLPIGSFLIRE-NSKTDTFVLVVRSSHNESPQAYIIYRRPNQEGFEIRDNHRPAV 274

Query: 164 -TFPSLHALVEHYS--ELADG--ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
             F SLH LV HYS  ++     IC  L +                PP+   T  +  KK
Sbjct: 275 IHFGSLHQLVNHYSCEKVPGEIQICTKLTK--------------AAPPLPEQTEYMAMKK 320

Query: 219 L---DRSLLFLEAPASGEASLLSEGLRESLSSYISLAE 253
           +      +  ++    G+   +     + +   +   +
Sbjct: 321 IHVNRSEVRRVKEIGRGQFGEVYLAKWKGVDVAVKSLK 358


>UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QBP3_IXOSC
          Length = 626

 Score =  132 bits (332), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 62/259 (23%), Positives = 102/259 (39%), Gaps = 28/259 (10%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           RG+T       S  D   V++Q         AL SF A E+  LSL  G    ++ + G+
Sbjct: 157 RGETGYLCARCSLLD---VALQVTTPARVVTALYSFQAIEKGDLSLEAGREYVVLDDSGE 213

Query: 67  WWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
            W    + SG    +PS YV + A    H W    +SR++AE++L       GAF++R S
Sbjct: 214 HWWQVRDGSGAVGFIPSNYVEQKAGLWQHEWYAGDMSRQRAEQVLRQETKE-GAFVVRNS 272

Query: 123 QTRRGCYSLSV------RLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
            T+ G ++LS+           + +  +RH +I+  D    Y+          +++    
Sbjct: 273 STQ-GFFTLSLLANSIMNSWASSLFKSLRH-KIEATDQ---YLETSYALNHAMSIMVFER 327

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
              D   C  R  C   +          P  T   S   W+     L  LE   SG+  +
Sbjct: 328 RGKD---CLFRNSCYYCQNSC-----CQPDSTNNPSLDKWEIDPSELALLEELGSGQFGV 379

Query: 237 LSEG-LRESLSSYISLAED 254
           +  G  R      + + ++
Sbjct: 380 VRRGKWRGCRDVAVKMMKE 398


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  131 bits (329), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 71/169 (42%), Gaps = 14/169 (8%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V   A  W +  ++R++AE LL       G FL+RES    G Y+L V         ++ 
Sbjct: 677 VKLNAMPWFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQS-----KVE 729

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HYR++ L+N  L I     F +L  LV HY   ADG+C  L + C+ +        ++  
Sbjct: 730 HYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-CLPKLGKQEFCINSKD 787

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                     W   +  L   E+   GE   +  G+  +    + + +D
Sbjct: 788 -----FVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKD 831


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score =  130 bits (327), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 57/234 (24%), Positives = 94/234 (40%), Gaps = 62/234 (26%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-- 62
           +S   +   S SS G D    +  P+   +    L +F       L+    E L IIS  
Sbjct: 165 TSMPNSHGSSTSSKGDD----NSIPDDFVLGVTTLYAFKGRTDEELNFDASELLDIISNP 220

Query: 63  -EDGDWWTVQSEVSGREYHMPSVYVAKVAH------------------------------ 91
            +D DWW  ++++ G    +PS YV  V +                              
Sbjct: 221 SDDQDWWKARNKL-GTVGLVPSNYVKVVENADPVCPTKFFIEDAVPPKPIEMHDEDNSFT 279

Query: 92  ----------GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
                      W +  ++R+ +E++L  PG   G FLIRES+T  G +++SV+     + 
Sbjct: 280 PSSSVGFYDRDWFHGRITRQDSEKILGCPG-ESGLFLIRESETMPGDFAVSVK-----AP 333

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA-----DG-ICCPLREP 189
           +R++H+++ R D    +   +  F SL  LV+HY         DG +   L  P
Sbjct: 334 ERVKHFKVTRSD--KKFCIGQRKFESLDDLVDHYKRSPIFSSDDGELKLYLTRP 385



 Score = 63.2 bits (152), Expect = 8e-09,   Method: Composition-based stats.
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)

Query: 30 ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
          E   V  VA   + + +   LS++  E L +I +   WW V+ + +GR  ++PS YV +
Sbjct: 3  EEEAVLVVAKWDYDSKQDEELSIKRNEKLKLIDDSRSWWKVE-KQNGRCGYVPSNYVKR 60



 Score = 58.9 bits (141), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 7/83 (8%)

Query: 6   SRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
           S   + SP P ++ P  E    QP R       +  + A ++  L+L  GE + ++ + G
Sbjct: 87  SPRNSESPHPHTAQPGNEMPFSQPAR------VMYHYKAAQEDELNLNKGEQVNVLEKSG 140

Query: 66  DWWTVQSEVSGREYHMPSVYVAK 88
           D W  + E +G +   PS YV++
Sbjct: 141 DGWW-RGECNGEKGWFPSNYVSE 162


>UniRef50_UPI00016E9C47 UPI00016E9C47 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9C47
          Length = 477

 Score =  129 bits (325), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 47/168 (27%), Positives = 77/168 (45%), Gaps = 14/168 (8%)

Query: 3   SLSSRGKTSSPSPSSSGPD---QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
             S +    +P+  + GP+   Q P    P    +T  A  ++       L L+  E  T
Sbjct: 180 RTSRKPLPPTPTEENPGPNVLLQAPEPQGPSV-GMTVTAEYNYLPMTTQDLELKKDEEYT 238

Query: 60  IIS-EDGDWWTVQSEVSGREYHMPSVYVAKVAHG-----WLYEGLSREKAEELLLLPGNP 113
           I+   D +WW  + +  G E ++PS YV +  +G     W  +  +R +AE+LL    N 
Sbjct: 239 ILEMSDPNWWRARDKY-GNEGYIPSNYVVEAENGLERFDWFCKNTNRSQAEKLLRTE-NK 296

Query: 114 GGAFLIRESQTRRGCYSLS-VRLSRPASWDRIRHYRIQRLDNGWLYIS 160
            G FL+R+S +R G Y++S +  S   +    RHY I     G  Y++
Sbjct: 297 DGGFLVRDS-SRPGKYTVSLLSKSGGDTGASCRHYNICTTPQGHFYLA 343


>UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYF4_SCHMA
          Length = 855

 Score =  129 bits (324), Expect = 9e-29,   Method: Composition-based stats.
 Identities = 34/136 (25%), Positives = 71/136 (52%), Gaps = 7/136 (5%)

Query: 24  PVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPS 83
             +   +  + T +A+ ++    + +L L+ GE   ++++    W     ++G+  ++P+
Sbjct: 304 QPTFDMDEGENTVIAVYNYNPVRENQLPLQKGEKYYVVNQSNAQWWYVKNMTGQLGYVPT 363

Query: 84  VYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            YV K     +  W Y+ ++R++AE +LL   N  G FL+R+S +++  Y+LSV    P 
Sbjct: 364 NYVHKPNSLNSFDWYYKDITRQQAEAILL-DENREGCFLVRDSVSKKNTYTLSVTSKDPE 422

Query: 140 SWD--RIRHYRIQRLD 153
           +    ++ HY I R +
Sbjct: 423 APGKLKVHHYHIHRTE 438



 Score = 74.3 bits (181), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 21/115 (18%), Positives = 45/115 (39%), Gaps = 13/115 (11%)

Query: 148 RIQRLDNG--WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           ++    NG    Y+S +  FP++  ++ ++   + G+   LR P         P KD   
Sbjct: 496 KVGSTINGEAQYYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSP---------PTKDRES 546

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAP-ASGEASLLSEGLRESLSSYIS-LAEDPLDD 258
           PVT       ++     L     P   G+  ++  G   ++   +  + E  +++
Sbjct: 547 PVTAGMGLDEFELDPAELHLEREPIGKGQFGVVKRGKFRNIPVAVKQMVEGAMNE 601


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  128 bits (322), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 60/213 (28%), Positives = 87/213 (40%), Gaps = 28/213 (13%)

Query: 21  DQEPVSMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISE-DGDWWTVQSEVSGRE 78
                  +P   K   VA   +        LS   GE   + +E  G W  V S+ SG  
Sbjct: 155 QYPAPPPEPVDDKKKVVATLPYNKVPDTDELSFSAGEVFVVHNELGGGWLWVTSQRSGES 214

Query: 79  YHMPSVYVAKVAHG--------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
             +    V  V           W +  +S+E+A E L   G+ GG FLIR S    G YS
Sbjct: 215 GIIVQDLVKPVEGEIDPNEGKVWFHGNVSKEEAAETLWKDGDIGG-FLIRNSDKNPGDYS 273

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLRE 188
           LS R       + I+ +RIQ+      Y+     + SL A+V+HY   E+ DG    LR+
Sbjct: 274 LSFR-----GPNTIQRFRIQKQQR--QYVMGGRYYNSLDAIVDHYKKEEIIDGF--KLRD 324

Query: 189 PCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDR 221
           P   +K             T  +S +N+++L R
Sbjct: 325 PTAPKKF------KNQTTSTEDSSPMNYEELRR 351



 Score = 87.8 bits (216), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 38/178 (21%), Positives = 75/178 (42%), Gaps = 21/178 (11%)

Query: 81  MPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
           + +   A   + W +  L R+ AE  L     P G++L+RES+ + G Y LS        
Sbjct: 56  VDANLTAPPENEWYHGCLDRQSAELRLNAADKP-GSYLVRESERKPGSYVLSYL-----G 109

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCV-------- 191
              I H+R+  +  G  Y+     F +L  L+ +Y+ +++ +    L+ P          
Sbjct: 110 QRGINHFRVTAVC-GDFYVG-GRQFQTLPELIGYYTHISNILKNERLQYPAPPPEPVDDK 167

Query: 192 LQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSL----LFLEAPASGEASLLSEGLRESL 245
            + +  LP    P    +  S+     +   L    L++ +  SGE+ ++ + L + +
Sbjct: 168 KKVVATLPYNKVPDTDELSFSAGEVFVVHNELGGGWLWVTSQRSGESGIIVQDLVKPV 225


>UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound protein 14 isoform 1 n=1
           Tax=Pan troglodytes RepID=UPI0000E1F79D
          Length = 491

 Score =  125 bits (315), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 39/175 (22%), Positives = 78/175 (44%), Gaps = 17/175 (9%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVY 85
                  + + VA+  F +G+++R+     E L++  E+G  W   +   G        +
Sbjct: 319 PPVRSISENSLVAM-DF-SGQKSRVIENPTEALSVAVEEGLAWRSSATNMGIHLKQSFAF 376

Query: 86  VAKVA------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
           +  ++        W +  +SR++A+ L++  G   G FL+R+SQ+    + LS+     +
Sbjct: 377 IHPISLAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSM-----S 431

Query: 140 SWDRIRHYRIQRL-DNGWLY---ISPRLTFPSLHALVEHYSELADGICCPLREPC 190
              +I+H++I  + D+G ++         F  L  LVE Y      + C L+  C
Sbjct: 432 HGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYC 486


>UniRef50_B1AH86 GRB2-related adaptor protein 2 (Fragment) n=3 Tax=Tetrapoda
           RepID=B1AH86_HUMAN
          Length = 97

 Score =  124 bits (312), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 37/101 (36%), Positives = 56/101 (55%), Gaps = 4/101 (3%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVA   F A  +  LS   G+ L I+S   +W+    E+  +E ++P  ++      W
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKA--ELGSQEGYVPKNFIDIQFPKW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
            +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR
Sbjct: 59  FHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR 97


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  124 bits (311), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 42/181 (23%), Positives = 75/181 (41%), Gaps = 38/181 (20%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSV 84
           Q  R       L  F +  +  L+   GE + +I +   D +WW  ++   G+   +P  
Sbjct: 192 QGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKN 250

Query: 85  YVAKVAH--------------------------GWLYEGLSREKAEELLLLPGNPGGAFL 118
           YV  ++                            W Y  ++R +AE  L   G   G FL
Sbjct: 251 YVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVE-GDFL 309

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           IR+S++    +S+S++ S        +H+++Q +DN  +Y   +  F ++  LVEHY + 
Sbjct: 310 IRDSESSPSDFSVSLKASGKN-----KHFKVQLVDN--VYCIGQRRFHTMDELVEHYKKA 362

Query: 179 A 179
            
Sbjct: 363 P 363



 Score = 62.0 bits (149), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 29/57 (50%), Gaps = 1/57 (1%)

Query: 33 KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV 89
          +V  +A   + A +   L ++  E L ++ +   WW V++  + R  ++PS YV + 
Sbjct: 4  EVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRN-AANRTGYVPSNYVERK 59



 Score = 44.3 bits (103), Expect = 0.004,   Method: Composition-based stats.
 Identities = 19/97 (19%), Positives = 36/97 (37%), Gaps = 7/97 (7%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERH----KVTAVALGSFPAGEQARLSLRLGE 56
           +G    +      SP+ S   + P +           + A    ++ A  +  LSL  G 
Sbjct: 77  LGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGS 136

Query: 57  PLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
            +T++ +    WW  +   +G+    PS YV +    
Sbjct: 137 RVTVMEKCSDGWW--RGSYNGQIGWFPSNYVLEEVDE 171


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  124 bits (311), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 37/151 (24%), Positives = 60/151 (39%), Gaps = 7/151 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE++E+ +   G   G FL+RE  T    ++L V +        I HY ++  
Sbjct: 163 WFHGAISREESEQRMKAFGLRDGLFLVRER-TEVNSFALCVAVKND-----IYHYLLEMN 216

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
             G L I     F +L  +V+HYS   DG+ C L + C + +         P  V     
Sbjct: 217 TLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVP-MPGAVVKRVK 275

Query: 213 SLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
               +  D  L       +G    +  G+  
Sbjct: 276 HGPRRIEDSELSTQGELGAGTFGTVRLGVYR 306



 Score =  117 bits (292), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 5/111 (4%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W +  +SR  AE+LL   G   G+FL+R+S T  G Y LS+            HY I
Sbjct: 6   KELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKK-----YHYII 60

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPG 200
            R  +G + I     F S   L++++++  DG+   L++PC      P  G
Sbjct: 61  SRHPDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQG 111


>UniRef50_Q5BYR6 SJCHGC04559 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BYR6_SCHJA
          Length = 206

 Score =  123 bits (308), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 47/195 (24%), Positives = 69/195 (35%), Gaps = 46/195 (23%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKVA 90
                A  +F   +   L     E L II+  +D +W   ++ + G    +P  YV +  
Sbjct: 14  GDVVTANYTFKKDKNEDLPFNKNETLKIINIGKDPNWAHAKNTL-GETGLIPLNYVQRKE 72

Query: 91  --------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSV--------- 133
                   H W +  +SR ++E LL   G P G+FLIRES    G  +L V         
Sbjct: 73  SALENIQDHCWYHGRISRAESESLL--SGCPIGSFLIRESDLYSGGLTLCVVGPSCMTDN 130

Query: 134 -----RLSRPASWDRIRHYRIQRLDNG-------------------WLYISPRLTFPSLH 169
                  S       ++HYRI R                          +     F SL 
Sbjct: 131 TDATDHQSSTDVMTNVQHYRIVRRPFKPTRFDQCFEYPATPICSKIHYTLDETDWFSSLL 190

Query: 170 ALVEHYSELADGICC 184
            LV+ YS+   G+ C
Sbjct: 191 ELVQFYSQPKRGLVC 205


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  121 bits (303), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 40/125 (32%), Positives = 63/125 (50%), Gaps = 10/125 (8%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           + W +  +SR+  E LL       G+FL+R S++  G  S++VR        R+ HYRI 
Sbjct: 239 YSWYHGAVSRQAGEHLLR--SGITGSFLVRASESAPGQLSVTVR-----HLGRVYHYRIS 291

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD---TPPPV 207
           +   G  YI+    FP++  L+EH+S  ADG+ CPL       +    P +    +  P 
Sbjct: 292 QDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQSCYSSVPQ 351

Query: 208 TVPTS 212
           T+P+S
Sbjct: 352 TLPSS 356


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score =  120 bits (302), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 53/220 (24%), Positives = 81/220 (36%), Gaps = 57/220 (25%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKVTAV-ALGSFPAGEQARLSLRLGEPLTIIS---ED 64
           K+SS   S          +QP    ++ V  L +F +G    L+    E L II    +D
Sbjct: 184 KSSSMPQSCPSSMPNTSHVQPASDCISVVRTLYAFNSGNPEELAFEQDEMLDIIEQPPDD 243

Query: 65  GDWWTVQSEVSGREYHMPSVYVAKV----------------------------------- 89
            +WW  ++   G    +P  YV  V                                   
Sbjct: 244 PEWWLARNSE-GLTGLVPMNYVEVVDGAQPVSSGNIQNYDRVCPQHNDIENMHAQNTAIG 302

Query: 90  ----------AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
                     +  W +  + R  AE+ L       G FL+R S+T  G YS+S+++    
Sbjct: 303 GNDGAADGIHSRDWYFGNMKRADAEQRLQDRA-DNGEFLVRGSETSSGDYSISMKM---- 357

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
              RIRH+++  L NG   I  +  F S+ AL+EHY    
Sbjct: 358 -PGRIRHFKVNTLPNGVFGIG-QRKFDSMDALLEHYKSAP 395



 Score = 60.5 bits (145), Expect = 6e-08,   Method: Composition-based stats.
 Identities = 15/54 (27%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 35 TAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
            VAL  + A E   LS++  E L ++     WW V++  + +   +PS Y+ +
Sbjct: 8  VVVALYDYSAKEGEELSIKKNEQLYLLDAKHTWWRVRNNAN-KIGLVPSNYLRR 60



 Score = 58.9 bits (141), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 22/87 (25%), Positives = 40/87 (45%), Gaps = 4/87 (4%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKV--TAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
                P  S+  P+ +P     +R  +    V+  ++ A +   L+LR G  + ++  D 
Sbjct: 100 RGAGEPQNSNHIPNLKPPGDGGDRAHMNEEYVSKFNYDATKDDELTLRKGMRVIVLQTDP 159

Query: 66  D-WWTVQ-SEVSGREYHMPSVYVAKVA 90
           D WW  + +E  G+  + PS YV K +
Sbjct: 160 DGWWYGKDAERPGQPGYFPSNYVVKSS 186


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score =  120 bits (301), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 31/151 (20%), Positives = 65/151 (43%), Gaps = 19/151 (12%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R++A++++       G FL+R + ++   Y+LS           ++HY I+  
Sbjct: 547 WYHADMTRQEADQVM--QNTNDGTFLVRNA-SKPKMYTLSFSFQ-----GVVKHYHIKTD 598

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
            +   Y+S R +F S+  L+E++   + G+   LR P               PPV +   
Sbjct: 599 SDNLFYVSQRHSFESVVQLIEYHKLNSAGLATRLRFPY---------TGTNNPPVLLGYG 649

Query: 213 SLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
                +    L  ++   +G+   + E L +
Sbjct: 650 VFQINRN--ELTIMKQIGTGQFGTVHEALWK 678


>UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI00004D86FC
          Length = 647

 Score =  119 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 33/153 (21%), Positives = 62/153 (40%), Gaps = 12/153 (7%)

Query: 105 ELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR-IRHYRIQRLDN-GWLYISPR 162
           ++ +L  +  G F++R S ++ G Y++S+           IRHY I+        Y++ +
Sbjct: 301 QMQMLQIDKEGGFIVRNS-SQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEK 359

Query: 163 LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
             F ++  ++E++   A G+   LR P           K+   P T   S   W+     
Sbjct: 360 HVFNTIPEMIEYHKHNAAGLVTRLRYPVC--------SKNKSAPTTAGFSYDKWEINPSE 411

Query: 223 LLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
           L F++   SG   ++  G  R      I    +
Sbjct: 412 LTFMKELGSGLFGVVRLGKWRAQYKVAIKAIRE 444


>UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=35 Tax=Euteleostomi
           RepID=Q64725-2
          Length = 606

 Score =  119 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 42/128 (32%), Positives = 58/128 (45%), Gaps = 11/128 (8%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
            A     W +  +SR+++E+ +L+     G FLIR      G ++L +         ++ 
Sbjct: 160 TAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARD-NNGSFALCLLHE-----GKVL 213

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL---PGKD 202
           HYRI R   G L I     F +L  LVEHYS   DG+   L  PC  QK+G     PG  
Sbjct: 214 HYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPC--QKIGVQMGHPGSS 271

Query: 203 TPPPVTVP 210
              PV  P
Sbjct: 272 NAHPVPPP 279



 Score = 98.2 bits (243), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 13/127 (10%)

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  ++RE+AE+ L+  G   G +L+R+S+   G ++LSV  +R A      HY I+R  
Sbjct: 15  FFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAH-----HYTIEREL 69

Query: 154 NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS 213
           NG   IS      S   L  ++S+  +G+ C L++P         PG     P T P   
Sbjct: 70  NGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKP-----FNRPPGVQ---PKTGPFED 121

Query: 214 LNWKKLD 220
           L    + 
Sbjct: 122 LKENLIR 128


>UniRef50_UPI000155BA92 PREDICTED: similar to Fyn-related kinase, partial n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BA92
          Length = 186

 Score =  118 bits (295), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 39/119 (32%), Positives = 56/119 (47%), Gaps = 12/119 (10%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSG-------R 77
           S    R     VAL  + A     LS   G+ L ++      WW  +    G        
Sbjct: 68  SRSSPRPAGIFVALFDYRARTAEDLSFVAGDRLQVLDASHPGWWLARLLGHGGDDPGQQS 127

Query: 78  EYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           + ++P+ Y+AK     A  W +  + R  AE+ LL  GN  GAFLIRES++++G YSLS
Sbjct: 128 QGYVPANYLAKDQSLQAEQWFFGAIKRVDAEKQLLYSGNRPGAFLIRESESQKGDYSLS 186


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  118 bits (295), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 41/176 (23%), Positives = 71/176 (40%), Gaps = 40/176 (22%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVYVAKV-- 89
           T  AL  F +G    L+    E + ++ +   D +WW  + E +G+   +P  YV  V  
Sbjct: 148 TVQALYHFSSGNVEELNFNKYELMDVLEKPENDPEWWKCRKE-NGQVGLVPKNYVTVVQK 206

Query: 90  ---------AHG-----------------WLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
                     H                  W Y  L+R +AE +L   G   G FLIR+S+
Sbjct: 207 THKELGISGPHPSNYDIKPSMDGKFGGKQWYYGKLTRHQAEMVLNQRG-VDGDFLIRDSE 265

Query: 124 TRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           +    +S+S++          +H+++   D    +   +  F ++  LVEHY +  
Sbjct: 266 SMPNDFSISLKALYKN-----KHFKVLLNDG--FFCIGQRKFSTMEDLVEHYKKAP 314



 Score = 42.4 bits (98), Expect = 0.016,   Method: Composition-based stats.
 Identities = 13/57 (22%), Positives = 25/57 (43%), Gaps = 3/57 (5%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAK 88
            + A+   ++ A  +  LSL  G  + ++ +    WW  +   +G     PS YV +
Sbjct: 63  NLPALVKFNYTAEREDELSLVKGTRVIVMEKCSDGWW--RGSYNGLSGWFPSNYVTE 117


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score =  117 bits (292), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 7/114 (6%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           + W +  +SR+  E LL       G+FL+R S++  G  S++VR        R+ HYRI 
Sbjct: 76  YSWYHGAVSRQAGEHLLR--SGITGSFLVRASESAPGQLSVTVR-----HLGRVYHYRIS 128

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           +   G  YI+    FP++  L+EH+S  ADG+ CPL       +    P + + 
Sbjct: 129 QDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQSC 182


>UniRef50_UPI0000D555ED PREDICTED: similar to CG33993 CG33993-PA n=2 Tax=Endopterygota
           RepID=UPI0000D555ED
          Length = 562

 Score =  116 bits (291), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 34/96 (35%), Positives = 53/96 (55%), Gaps = 2/96 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE A E+L     P GAF++RES ++ GC++LS+R+ R      I HY I R
Sbjct: 428 PWFQAGIPREIALEILAQE--PVGAFMVRESTSKPGCFALSLRVPRSFQPTGIAHYLIVR 485

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            + G+        F +L +L+ H+S + + + CPL 
Sbjct: 486 TNKGYKIKGFTKEFTTLTSLITHHSVMPELLPCPLS 521


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score =  116 bits (291), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 6/99 (6%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  LSRE+AE+ ++  G   G FL+RE  T  G ++LS+  +     + + HY+I +
Sbjct: 210 PWFHHKLSREEAEQRIVSAGLQEGKFLVRER-TEEGSFALSLCYN-----NFVYHYKIDK 263

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
              G L I     F SL  +V+HY    DG+ C L  PC
Sbjct: 264 DCTGQLSIKEGPKFDSLIQMVDHYQLKKDGLLCCLLVPC 302



 Score =  100 bits (250), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 36/109 (33%), Positives = 54/109 (49%), Gaps = 5/109 (4%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V  ++  + +  ++RE+AE  L   G   G FL+RES  R G Y+LS+        D + 
Sbjct: 49  VDPLSRRFYHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYE-----DDVY 103

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
           HY I+R  +G + I     F     LV ++    DG+ C L  PC LQ+
Sbjct: 104 HYAIERQYDGTVAIKDGKNFAGPIELVSNHMNREDGLLCRLLRPCNLQQ 152


>UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostomi RepID=KSYK_HUMAN
          Length = 635

 Score =  116 bits (290), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 6/105 (5%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
            A     W +  +SRE++E+++L+     G FLIR      G Y+L +         ++ 
Sbjct: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARD-NNGSYALCLLHE-----GKVL 214

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           HYRI +   G L I     F +L  LVEHYS  ADG+   L  PC
Sbjct: 215 HYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259



 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 32/98 (32%), Positives = 54/98 (55%), Gaps = 5/98 (5%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            + +  ++RE+AE+ L+  G   G +L+R+S+   G ++LSV   R A      HY I+R
Sbjct: 14  PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAH-----HYTIER 68

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
             NG   I+   T  S   L  ++S+ +DG+ C L++P
Sbjct: 69  ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  116 bits (290), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 49/212 (23%), Positives = 83/212 (39%), Gaps = 51/212 (24%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS---E 63
           + ++S  S S    D   V  +P   KV    L  F +  +  LS      L II    +
Sbjct: 159 KVESSDGSTSEYA-DPSDVMDKPIISKVRT--LYPFKSQSKEELSFDKDIILEIIDKPKD 215

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKVAHG------------------------------- 92
           D DWW  + + +G    +P  YV ++                                  
Sbjct: 216 DPDWWRAR-KSNGEIGLVPRNYVEEIVSPVLTPGPTKPKHSISSLNTNPPIVKDETPDCI 274

Query: 93  -----WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
                W +  LSR + E LL       G +LIR S+++ G +SLS++     + +RI+H+
Sbjct: 275 FRDKDWYHGTLSRSECEFLLNEHAK-DGEYLIRNSESKPGDFSLSMK-----APNRIKHF 328

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           +I   +N   Y+  + +F ++  L+ HY    
Sbjct: 329 KILYGNN--QYVIGQRSFSNIDELLSHYKNYP 358



 Score = 62.8 bits (151), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 1/59 (1%)

Query: 31 RHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV 89
            +  A+A   + A     L++R  E L +I +   WW VQ+E S    ++PS Y+A+ 
Sbjct: 2  EQESVAIAKYDYTAAGDGELTIRKNEKLVVIDDSQPWWKVQNEKSV-SGYVPSNYLARK 59



 Score = 46.6 bits (109), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/86 (20%), Positives = 34/86 (39%), Gaps = 2/86 (2%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           L ++  +  P  S +   Q   S    +  + A +   +       L L  G+ + +I  
Sbjct: 77  LKNKRTSIDPFDSVTDV-QNIKSKSGAKVLMVAFSKFKYTPQRDDELELNRGDQVLVIEM 135

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKV 89
           + D W  + E +G+    P  Y+ KV
Sbjct: 136 EHDGW-CRGECNGKVGWFPFNYIQKV 160


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score =  116 bits (290), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 43/151 (28%), Positives = 67/151 (44%), Gaps = 24/151 (15%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE+AEE+L   G   G F++RES +  G + LSV        D + HY+I+R 
Sbjct: 9   WFHGKISRERAEEILRQEGG-DGVFMVRESASSEGDFVLSVLFQ-----DEMVHYQIRRH 62

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
            D+ +  I        L +L+EHY E  +G+   L+  C          +  PPP  V  
Sbjct: 63  GDDAFFSIDDHTPIHGLESLIEHYRESPNGLVTKLQAIC----------RGKPPPHDV-- 110

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
                +      L   A  +    ++SE L+
Sbjct: 111 -----RSHGTENLLHRATQANNFPIVSELLK 136



 Score = 66.2 bits (160), Expect = 1e-09,   Method: Composition-based stats.
 Identities = 32/122 (26%), Positives = 46/122 (37%), Gaps = 35/122 (28%)

Query: 93  WLYEGLSREKAEELLLL-----------PGNPG-----------------GAFLIRESQT 124
           W +  L R+ A ++L             P                     G +L+R S  
Sbjct: 284 WYHGTLDRQIAVDILKEHAGKLMPGACSPSKEDKENDSTRSNDNETLDTSGVYLVRYSPK 343

Query: 125 RRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC 184
           + G   L++     A     RH+ IQR  N +LYI       SL  L+EHYS  +DG+  
Sbjct: 344 Q-GVDVLTLLFDNEA-----RHFIIQRKQN-YLYIDDGPYMASLEHLIEHYSRFSDGLQI 396

Query: 185 PL 186
            L
Sbjct: 397 NL 398


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  116 bits (290), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SRE AEE+L   G+  G FL+RES +  G Y LSV          + HY I+R 
Sbjct: 9   WFHGKISREDAEEILRREGS-DGVFLVRESSSSEGDYVLSVLFK-----GEVVHYAIRRH 62

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
            D+ +  I        L +L+EHY +    +   L+  C          +  PPP  V  
Sbjct: 63  GDDAFFSIHDHTPIHGLDSLIEHYQKDKGNLVTRLQVIC----------RSDPPPHDV-- 110

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
                +    + L   A      +++SE L+
Sbjct: 111 -----RSHGTTNLLHRATKESNYTVVSELLK 136



 Score = 77.0 bits (188), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 34/146 (23%), Positives = 50/146 (34%), Gaps = 40/146 (27%)

Query: 93  WLYEGLSREKAEELLL---------------------------------LPGNPGGAFLI 119
           W +  L R  A + L                                  L  +  G +L+
Sbjct: 284 WYHGTLERTAAVDYLKDFAVKLLPNLAHRQQQQQPDRDGNKENGECLDGLEQSTSGTYLV 343

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           R S  +       +  + P      +H+ IQR  + WLYI       SL  L+EHY+  +
Sbjct: 344 RYSAKQNVDVLTMLYDNEP------KHFIIQRQQD-WLYIDEGPYMNSLEHLIEHYTRFS 396

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPP 205
           DG+   LR P       P+P   T P
Sbjct: 397 DGLPINLRFPVTPGPKPPIPAFATIP 422


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score =  116 bits (290), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 43/169 (25%), Positives = 71/169 (42%), Gaps = 24/169 (14%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  LSR+ AE+ L+   N  G FL+RES    G + L++  +       I HY+I R
Sbjct: 8   SWFHGKLSRDDAEK-LIQDLNSEGGFLVRESFASPGDFVLTLLHNGD-----IVHYQILR 61

Query: 152 L-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             ++ +  I     F  L  L+ ++ E  +G+   L   C          KD PP  T  
Sbjct: 62  HGEDAFFSIDNEHIFHGLETLINYHQENENGLITKLTNFC---------KKDPPPHDT-- 110

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
                 +   ++ L   A   G  +++SE L+    +  + +ED    A
Sbjct: 111 ------RCHGKTNLLHRATKEGNYTVVSELLKCGYRNTDAKSEDGQTAA 153



 Score =  106 bits (265), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 34/110 (30%), Positives = 60/110 (54%), Gaps = 8/110 (7%)

Query: 77  REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
           R+Y  P   ++K  + W +  L R++A ELL   GN  G++L+R S    G Y L++ ++
Sbjct: 270 RKYKAPKPVLSK--YNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVN 327

Query: 137 RPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
                DR  H++I+  +NG+ +I       SL  ++++YS + DG+   L
Sbjct: 328 -----DRSFHFQIKN-ENGYYFIDDGPLLESLEHVIDYYSRMQDGLPTVL 371


>UniRef50_UPI00015B5EF2 PREDICTED: similar to ENSANGP00000021630 n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B5EF2
          Length = 389

 Score =  115 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 35/96 (36%), Positives = 52/96 (54%), Gaps = 2/96 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE   E+L     P GAF++RES ++ GCY+LS+R+ R      I HY I R
Sbjct: 255 PWFQAGIPREITLEVLSQE--PEGAFMVRESTSKPGCYALSLRVPREFQPSGIAHYLIMR 312

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            + G+        F +L AL+ H+S + + + CPL 
Sbjct: 313 TNKGYKIKGFTKEFTTLTALITHHSVMPELLPCPLS 348


>UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n=1 Tax=Ciona intestinalis
           RepID=UPI000180C4D7
          Length = 525

 Score =  115 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 42/240 (17%), Positives = 84/240 (35%), Gaps = 34/240 (14%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISED 64
           +S     +P            +  P   ++    +  +P            E + I+++ 
Sbjct: 69  ASNMVGPTPLSQMRNLSLNQEANPPTTEELNYETIWGYPP-------FNRAESICILNKQ 121

Query: 65  GDWWTVQSEVSGREYHMPSVYVA----KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           GDWW  +S  +G+E  +PS YVA         W +   S ++ E +L+      G ++I 
Sbjct: 122 GDWWKARSRETGQEGFIPSNYVALEDSIECERWFFGKKSEKECERMLVQQ--KPGTYMIT 179

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES+T  G Y +S+ +    +   ++H  I           P           +H+ +   
Sbjct: 180 ESKTEPGIYRISLTIQEALTLL-VKHQTIPL---------PHDRHH------KHHKQAFI 223

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           G           Q+   +   +   P T   +  +W+     L   +   +G    + +G
Sbjct: 224 G-----NYIGRAQRGSIMKYGEHEKPETSGIAPGDWEIGREHLTQQKKLGAGAFGEVWKG 278


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score =  115 bits (288), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 42/159 (26%), Positives = 68/159 (42%), Gaps = 29/159 (18%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE  E LL   G P G+FL+RES +  G + LSV  +     + + H++I+R 
Sbjct: 9   WYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHN-----NEVSHFQIRRH 63

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSEL----ADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            ++ +  I        L +L+EHY       ++G+   L  P            D PP  
Sbjct: 64  SEDAFFSIDENTKIHGLESLIEHYVNTKGILSEGL--SLTVPV---------KGDAPPDY 112

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS 246
           +        ++  R+ L   A   G   ++SE L+    
Sbjct: 113 S--------RRHGRTNLLHRATKEGNYKVVSEVLKTGYR 143



 Score = 85.1 bits (209), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 45/106 (42%), Gaps = 9/106 (8%)

Query: 85  YVAKVAHG--WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
             A   H   W +  L R +AE  +       G FL+R S   +       R+    +  
Sbjct: 276 CPAPKTHRSYWYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNKE------RVLTLINES 329

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
              +Y I++ D+ +L+I       SL  ++E+YS + DG+   L+ 
Sbjct: 330 LFYNYIIRKQDD-YLFIDNGPYLESLEHIIEYYSFIPDGLPTVLQT 374


>UniRef50_UPI000186F028 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186F028
          Length = 378

 Score =  115 bits (287), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 35/96 (36%), Positives = 51/96 (53%), Gaps = 2/96 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE   E+L     P GAF++RES ++ GCY+LS+R+ R      I HY I R
Sbjct: 244 PWFQAGIPREITLEVLGQE--PVGAFMVRESTSKPGCYALSLRVPRDFQPSGIAHYLIMR 301

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
              G+        F +L AL+ H+S + + + CPL 
Sbjct: 302 TMKGYKIKGFTKEFTTLTALITHHSVMPELLPCPLS 337


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 44/190 (23%), Positives = 76/190 (40%), Gaps = 19/190 (10%)

Query: 55  GEPLTIISEDGDWWTVQ---SEVSGR--EYHMPSVYVAKVAHGWLYEGLSREKAEELLLL 109
           GE    + E   ++       E +G+  E   P +        W +  LS ++AE+L+L 
Sbjct: 68  GEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILE 127

Query: 110 PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLH 169
            G   G+FL+RESQ++ G + LSVR     + D++ H  I+  D     +    +F +L 
Sbjct: 128 RGK-NGSFLVRESQSKPGDFVLSVR-----TDDKVTHVMIRWQDK-KYDVGGGESFGTLS 180

Query: 170 ALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF 225
            L++HY         G    LR+P    ++    G +      V      W++ +     
Sbjct: 181 ELIDHYKRNPMVETCGTVVHLRQPFNATRITA-AGINARVEQLVKGGF--WEEFESLQQD 237

Query: 226 LEAPASGEAS 235
                S    
Sbjct: 238 SRDTFSRNEG 247



 Score = 87.0 bits (214), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 12/103 (11%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +S  +AE+LL   G   G+FL R S +  G ++LSVR       + + H +IQ 
Sbjct: 5   RWFHPTISGIEAEKLLQEQG-FDGSFLARLSSSNPGAFTLSVR-----RGNEVTHIKIQN 58

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSEL-----ADGICCPLREP 189
             + +  +     F +L  LV++Y E       +G    L++P
Sbjct: 59  NGD-FFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQP 100


>UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E4312
          Length = 350

 Score =  114 bits (284), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 48/173 (27%), Positives = 75/173 (43%), Gaps = 16/173 (9%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQ-----SEVSGREYHMPSVYV 86
            + + VA+  F      R+     E  +   E+G  W  +     S  +      PS+ V
Sbjct: 185 SEASLVAM-DFSGKAGGRVIQNPAEAQSAEQEEGQAWRRREALRCSLPNLNSGPKPSLAV 243

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
             V+  W + G+SR++A+ L+   G   G FLIRESQ    C+ LS+         +I+H
Sbjct: 244 H-VSQPWFHGGVSRKEAQRLIEKQGLVDGMFLIRESQQHGQCFVLSLSHQL-----KIKH 297

Query: 147 YRIQRLDNG---WLYISPRLT-FPSLHALVEHYSELADGICCPLREPCVLQKL 195
           Y +   ++G   +  I   LT F  L  LVE +      +   L+ PCV   L
Sbjct: 298 YLVIPCEDGGRKYFTIDDGLTLFIDLLQLVEFHQINKGILPVCLKHPCVCVAL 350


>UniRef50_Q70W05 Src protein (Fragment) n=1 Tax=Ciona intestinalis
           RepID=Q70W05_CIOIN
          Length = 355

 Score =  114 bits (284), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 31/122 (25%), Positives = 51/122 (41%), Gaps = 10/122 (8%)

Query: 21  DQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQ-----SEVS 75
              P    P+  +   +AL  + A     L+ + G+ + I+ +  +W   Q        S
Sbjct: 9   QDRPAPPIPQIEEDIYIALYDYVARTNEDLTFKKGDTMVILKKGENWSIAQLLEPNPLYS 68

Query: 76  GREYHMPSVYVAKVA-----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
             E  +P+ YV K +       W+++   R +A  LL+ P N  G FL R   T    Y+
Sbjct: 69  VTEGSIPTNYVKKQSSVVSQPSWMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNPNEYA 128

Query: 131 LS 132
           LS
Sbjct: 129 LS 130


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  113 bits (283), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 23/152 (15%)

Query: 93  WLYEGLSREKAEELLL-LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SR+ AE +LL       G FL+RES +  G Y L V  +     + + HY+I+R
Sbjct: 12  WYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQN-----NEVVHYQIRR 66

Query: 152 L-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             ++ +  I  +     L  L+EHY        C + +P +  +L     KD PP  T  
Sbjct: 67  HGEDAFFSIDEQNIMHGLETLIEHY--------CKVNDPSLGVQLSKPIVKDPPPHDT-- 116

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
                 ++  R+ L   A       +++E L+
Sbjct: 117 ------RRHGRTNLLHRAITQANCKVVTELLK 142



 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 36/154 (23%), Positives = 61/154 (39%), Gaps = 12/154 (7%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W +  L R +A  +L    +  G FL+R    R+  Y LS+  +     ++  H++I
Sbjct: 287 KDQWYHGKLDRHEATAILKTK-DVDGCFLVR--MNRQSGYVLSMMCT-----NQCYHFQI 338

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK---DTPPP 206
           Q  D  + +I       SL  L++HY+   DG+   L  P     + PLP         P
Sbjct: 339 QDRDK-YYFIDNGPYLNSLEHLIQHYTLFPDGLPNKLEVPVSPAVIPPLPKGFPFTLKKP 397

Query: 207 VTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
                +      +  +L+  E    GE   + +G
Sbjct: 398 KPKHQTEFQDNIMRDNLILDEVIGEGEFGSVYKG 431


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score =  113 bits (282), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 62/213 (29%), Positives = 90/213 (42%), Gaps = 55/213 (25%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQ---PERHKVTAVALGSFPAGEQARLSLRLGEP---- 57
           SS+   S  + S+ G D E    +   PER K +     SF       LSLRL  P    
Sbjct: 552 SSKIYYSEETSSNQGNDDEEEHKEVRRPERKKKS-----SFSRVLLTDLSLRLRPPTFPD 606

Query: 58  ---LTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS-----REKAEELL-- 107
              L +++            +G + H+           W +  L      R+ AE LL  
Sbjct: 607 RLVLVLVNFQA--------SNGMDQHV--------TEKWFHGKLGAGRDGRQIAERLLSE 650

Query: 108 --LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPR 162
             +  G P G+FL+RES+T  G Y+LS   S      R++H RI  R + G    Y++  
Sbjct: 651 YCMETGAPDGSFLVRESETFVGDYTLSFWRS-----GRVQHCRIHSRQEAGSPKFYLTDN 705

Query: 163 LTFPSLHALVEHYSELADGICC-----PLREPC 190
           L F +L AL+ HY ++A  + C      L EP 
Sbjct: 706 LVFDTLFALINHYQQVA--LRCNEFEMKLTEPV 736



 Score = 82.8 bits (203), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 9/103 (8%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
           A  +  W +  LSR +AE +L+      GAFL+R+       +++S R     +  +I+H
Sbjct: 741 AHESKEWYHANLSRSQAENMLMRVPR-DGAFLVRKRA-EPNSFAISFR-----AEGKIKH 793

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            R+Q+   G   +     F SL  L+ +Y +        LR P
Sbjct: 794 CRVQQ--EGQTVVLGTSEFDSLVDLISYYEKHPLYRKMKLRYP 834



 Score = 46.2 bits (108), Expect = 0.001,   Method: Composition-based stats.
 Identities = 15/90 (16%), Positives = 30/90 (33%), Gaps = 4/90 (4%)

Query: 7   RGKTSSPSPSSSGPDQEP----VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           +  T+ P   S    + P     + Q    K T  A+  + A     LS      +  + 
Sbjct: 842 KIGTAEPDYGSLYEGRNPGFYVEANQMPTFKCTVRAMYEYKAQRDDELSFTKNAIIYNVD 901

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
           +    W        ++   P+ YV +++  
Sbjct: 902 KQEGGWWKGDCGGKKQLWFPANYVEEISPS 931


>UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi sarcoma viral oncogene
           homolog 1 n=1 Tax=Ciona intestinalis RepID=UPI000180BC98
          Length = 432

 Score =  112 bits (280), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 42/172 (24%), Positives = 71/172 (41%), Gaps = 12/172 (6%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
               +    +  +SRE+AE  LL  G   G FL+R+     G Y +S+  S      R+ 
Sbjct: 18  ETIESEPCYFGTISREEAETNLLERGENDGTFLVRKGTD--GEYRISLLSSTSDGSCRVY 75

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           +YR++   N    I    +FP++H LV +YS+   G+   L  PC  + L   P     P
Sbjct: 76  NYRVKLATNRTYSIDDTYSFPAVHQLVRYYSQKCSGLPSKLVAPCPKEDLEKEPESGFHP 135

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG--LRESLSSYISLAEDP 255
            + V            S+      + G  S + +   LR + ++  +L+   
Sbjct: 136 LLPV--------IAGSSVEMRSQLSCGSYSEIWKANYLRTTFAAKCALSNHC 179


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score =  112 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 32/121 (26%), Positives = 53/121 (43%), Gaps = 5/121 (4%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
                + +L++ + R  A E L   G   G+FLIR +  + G Y+L++   +        
Sbjct: 285 PRMNTNDFLHKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTP-----Y 339

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HY +    + W +I     F +L A+V+HY+  ADG+   L  P        +P    P 
Sbjct: 340 HYEVVCESDCWYFIDDGPLFDTLPAVVDHYTIFADGLPTTLLYPVPPSGRKNVPFSSPPQ 399

Query: 206 P 206
           P
Sbjct: 400 P 400



 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 35/150 (23%), Positives = 55/150 (36%), Gaps = 10/150 (6%)

Query: 90  AHGWLYEGLSREKAEELLLLPG--NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
           A  W +  ++RE A  L+         G FL+RES    G Y L++          ++ +
Sbjct: 7   AERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAK-----GNVQQF 61

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
           +I     GW  +     F  L  L+ HY    DG+   L +  +     P P        
Sbjct: 62  QIMGHGEGWFSVDNGPLFQGLDELIHHYQLKPDGLPVQLNDYVIG---NPPPPGARKRTE 118

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLL 237
           T    ++  + L   L  L  PAS     +
Sbjct: 119 TELHKAVATRDLAAVLSILSQPASSNLGTV 148


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  112 bits (279), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 39/164 (23%), Positives = 62/164 (37%), Gaps = 16/164 (9%)

Query: 55  GEPLTIISE------DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL 108
           GE    ++E      +      +      E   P       +  W +  LS  +AE+LL 
Sbjct: 68  GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLT 127

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRP-----ASWDRIRHYRIQRLDNGWLYISPRL 163
             G   G+FL+RESQ+  G + LSVR          S  ++ H  I+   +    +    
Sbjct: 128 EKGK-NGSFLVRESQSHPGDFVLSVRTGDDKTDSSDSKPKVTHVMIRCQHDLKYDVGGGE 186

Query: 164 TFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDT 203
            F SL  LVEHY +       G    L++P    ++     +  
Sbjct: 187 KFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESR 230



 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 49/108 (45%), Gaps = 13/108 (12%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  ++  +AE LLL  G   G+FL R S++  G ++LSVR         + H 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVR-----RNGAVTHI 54

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSEL------ADGICCPLREP 189
           +IQ   + +  +     F +L  LV++Y E        +G    L+ P
Sbjct: 55  KIQNTGD-YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP 101


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 44/179 (24%), Positives = 71/179 (39%), Gaps = 26/179 (14%)

Query: 37  VALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVS-----GREYHMP------SVY 85
           VA+  F  G + R+     E + +  E+G  W  +         G   + P      S +
Sbjct: 563 VAM-DFT-GYRGRVIANPNEAVAVAVEEGQSWRKRHSSGSRALVGSPRNSPLLSPRSSRF 620

Query: 86  VAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           ++         W + G++RE+A  ++ + G   G +L+RESQT  G + L+         
Sbjct: 621 ISPQGVHQTQPWFHHGINREEANNMMHMQGMVDGLYLVRESQTFPGTFVLTF-----CHD 675

Query: 142 DRIRHYRIQRL--DNGWLY--ISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
            R++HY+IQ    D+   Y        F  L  LVE Y      +   L  PC    L 
Sbjct: 676 QRVKHYQIQPNVIDDKTFYSLDEGETKFGDLVQLVEFYQINRGALPHSLTHPCTGAGLR 734


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 42/217 (19%), Positives = 82/217 (37%), Gaps = 24/217 (11%)

Query: 26  SMQPERHKVTAVALGSFPAG-EQARLSLRLGEPLTIISEDGD-WWTVQSEVSGREYHMPS 83
             +P   K   VA+  +    E   LS + G+   + ++ GD W  V +  +G +  +  
Sbjct: 176 PPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFR 235

Query: 84  VYVAK--------VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
             V              W +   ++ +A ++L+  G   G+FL+R S    G YSL   +
Sbjct: 236 ELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAG--PGSFLVRPSDNSPGDYSLFFHI 293

Query: 136 SRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA--DGICCPLREPCVLQ 193
           +     ++I+ +RI++   G  Y+    TF  L A++  Y +    +G    L  P V  
Sbjct: 294 N-----NQIQRFRIEK--KGVRYLMGGRTFECLDAVINRYRKEQIVEG--HSLNHPVV-N 343

Query: 194 KLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
            + P   +               ++    +   +   
Sbjct: 344 GIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKG 380



 Score = 87.4 bits (215), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 39/156 (25%), Positives = 56/156 (35%), Gaps = 19/156 (12%)

Query: 79  YHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
              P++ +A     W +  L R  AE  L       G++L+RES  + G Y LS      
Sbjct: 71  GERPAI-IAPPESEWYHGRLDRYSAESRLRGSSKL-GSYLVRESDRKPGSYVLSYY---- 124

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCVLQKLGP 197
                I H+RI  +  G  YI     F SL  LV +Y+  +D +    L  P       P
Sbjct: 125 -GRTGINHFRITAVC-GDFYIG-GRQFISLSDLVGYYTSCSDLLKRERLAIPVAP----P 177

Query: 198 LPGKDTP-----PPVTVPTSSLNWKKLDRSLLFLEA 228
            P  D        P T    +         + F+  
Sbjct: 178 EPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHN 213


>UniRef50_B7QKA0 Putative uncharacterized protein n=1 Tax=Ixodes scapularis
           RepID=B7QKA0_IXOSC
          Length = 346

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 31/96 (32%), Positives = 52/96 (54%), Gaps = 2/96 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE A E+L     P G+F++R+S ++ GC++LS+R+ R      I HY I  
Sbjct: 213 PWFQAGIPREIALEVLGQE--PVGSFMVRKSTSKPGCFALSLRVPRSLQPTGISHYLIMH 270

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            + G+        F +L +L+ H+S + + + CPL 
Sbjct: 271 TNRGYKIKGFTKEFGTLTSLITHHSVMPELLPCPLS 306


>UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia tigrina
           RepID=SPK1_DUGTI
          Length = 497

 Score =  111 bits (277), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 45/235 (19%), Positives = 84/235 (35%), Gaps = 28/235 (11%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKV----- 89
             A   + A     +S    E + ++ + D  W  V  +   +E  +PS YV+K      
Sbjct: 38  VKAKYKYAASGDTDISFEEKEIMYVLEQFDEFWLKVVKQKDNKEGLVPSNYVSKQDGSPQ 97

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW-DRIRHY 147
               W    + R +AE+ L+  G   G ++IR S+     Y+LSVR          ++H+
Sbjct: 98  SVEAW--REIQRWEAEKSLMKIGLQKGTYIIRPSRKE-NSYALSVRDFDEKKKICIVKHF 154

Query: 148 RIQ--RLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCVLQKLGPLPGKDTP 204
           +I+  + + G  Y      FP++  L++ Y +   G    PL +P              P
Sbjct: 155 QIKTLQDEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDP-------------MP 201

Query: 205 PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAEDPLDD 258
                P    + +    ++  L     G    +       S      + +    +
Sbjct: 202 DNYQPPVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAKMLQSSKAE 256


>UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa RepID=O77440_HYDAT
          Length = 624

 Score =  111 bits (277), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 41/174 (23%), Positives = 73/174 (41%), Gaps = 16/174 (9%)

Query: 59  TIISEDGDWWTVQSEVSGREYHMPSVYVA----KVAHGWLYEGLSREKAEELLLLPGNPG 114
           T++  +G    V +E + R++ +   YV          W +  + R +AE  L       
Sbjct: 127 TVLRTEG----VVNEEAVRKFKVKMEYVVGNILHRQQPWFHGVIPRTEAERRLKSLS-ET 181

Query: 115 GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEH 174
           G FLIRE  + RG Y + +          + HY  +  + G L I    +F +L A+V  
Sbjct: 182 GMFLIRERGSPRGSYVIGLFYQ-----GGVYHYLFESNNQGQLSIKSGRSFDNLMAVVNF 236

Query: 175 YSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
           YS+ ++G+ C L+  C +      P  +    + +        +L ++LL  E 
Sbjct: 237 YSQKSEGLFCTLKRACEVSWFEFQPKTEIYKNILLHPEI--QAELKKTLLLYED 288



 Score =  102 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 6/100 (6%)

Query: 92  GWLYEGLSREKAEELLLLP-GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
            W +  ++R+ AE  L        G +L+RES +  G Y LSV         ++ HY IQ
Sbjct: 8   RWFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSV-----CKDKKVIHYAIQ 62

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           R  +G + I+    FP    LV H+     G+   L  PC
Sbjct: 63  RQPSGMVGIADGPQFPGPVELVNHHKTSLGGLMTKLTYPC 102


>UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepID=HTK16_HYDAT
          Length = 757

 Score =  111 bits (277), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 38/139 (27%), Positives = 56/139 (40%), Gaps = 13/139 (9%)

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           P          WL++ L R  A  +L       G+FLIR S    G Y L++   +    
Sbjct: 276 PVNQPKTSITQWLHQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKT-- 333

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
               H++I+   + W YI     F +L  LV+HY + ADG+   L+ P         P  
Sbjct: 334 ---YHFQIKSRADRWFYIDDGPLFETLPHLVDHYMQYADGLPTLLQFPV--------PSA 382

Query: 202 DTPPPVTVPTSSLNWKKLD 220
           +       PT + N  KL 
Sbjct: 383 ENRKRPLPPTPTKNQLKLP 401



 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 5/101 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++RE A ++LL  G   G FLIR+       Y LS+         +I H++I  L
Sbjct: 10  WYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRS-----QILHFQINCL 64

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
            +    I     F  L  L+ +Y  ++DG+ C L + CV +
Sbjct: 65  GDNKFSIDNGPIFQGLDMLISYYKVISDGLPCKLVDFCVGK 105


>UniRef50_UPI000180B667 PREDICTED: similar to GF12762 n=1 Tax=Ciona intestinalis
           RepID=UPI000180B667
          Length = 886

 Score =  110 bits (274), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 5/104 (4%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            WL++ + R KA E+L + G   G+F++R S+   G + L++     A    + +Y I+ 
Sbjct: 477 SWLHDAMDRFKAVEMLEMSGLVDGSFMVRLSKRNPGQHVLTM-----AHDKTVYNYEIRN 531

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKL 195
             N W YI     F SL  LV++Y   +DG+   L  PC     
Sbjct: 532 RGNQWYYIDDGPLFTSLEYLVDYYCRRSDGLPAELTSPCTTYDT 575



 Score =  106 bits (265), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 31/103 (30%), Positives = 51/103 (49%), Gaps = 5/103 (4%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            WL++ + R KA E+L + G   G+F++R S+   G + L++     A    + +Y I+ 
Sbjct: 320 SWLHDAMDRFKAVEMLEMSGLVDGSFMVRLSKRNPGQHVLTM-----AHDKTVYNYEIRN 374

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
             N W YI     F SL  LV++Y   +DG+   L  P    +
Sbjct: 375 RGNQWYYIDDGPLFTSLEYLVDYYCRCSDGLPAELTSPVPSAR 417



 Score =  100 bits (249), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 18/147 (12%)

Query: 52  LRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPG 111
           L+LGEPL  I++              + +  ++   K    W +E L+R  AE  L   G
Sbjct: 14  LKLGEPLADITQH------------YQSYSSTISSKKPEDLWFHEKLTRGNAEFNLKKYG 61

Query: 112 NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLY-ISPRLTFPSLHA 170
           N  G FL+RES    G + LS+  +      + +H++I    +   + I     F  L  
Sbjct: 62  NEQGMFLVRESINVPGSFVLSLTHN-----GKAQHFQINTSIHSGCFSIDNGPPFVGLDQ 116

Query: 171 LVEHYSELADGICCPLREPCVLQKLGP 197
           L+  Y   ++G+   L   CV  +L P
Sbjct: 117 LIAFYRAASNGLPTILTRSCVGYELRP 143


>UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine kinase n=3
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48523
          Length = 837

 Score =  110 bits (274), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 54/126 (42%), Gaps = 5/126 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R+ A  +L   G+  G FL+RES +R G Y +S+  +        +H++IQ +
Sbjct: 76  WFHGRITRDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSIMHNGLP-----QHFQIQCM 130

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
            + +  I     F  L  L+ +Y   ++G+   L   C  +   P   +          +
Sbjct: 131 GDFYYKIDNGPLFQGLDQLINYYRMGSNGLPTKLTVFCNGRIPPPCSRRFGRTTPLHRAT 190

Query: 213 SLNWKK 218
              W +
Sbjct: 191 FEKWSE 196



 Score =  100 bits (248), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 51/123 (41%), Gaps = 12/123 (9%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  + R+KA E +   G   G FL+R S  +     LS+     A+   + ++ I  
Sbjct: 350 PWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSM-----AANGTVFNFEI-N 403

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK-DTPPPVTVP 210
                 YI     F +L  L++HYS   DG+   L  P     + P PG+ D  PP    
Sbjct: 404 TKMESFYIDDGPYFDTLEQLIDHYSRYDDGLPTMLLHP-----IPPPPGRIDNGPPTREK 458

Query: 211 TSS 213
            S 
Sbjct: 459 PSP 461


>UniRef50_A7URX1 AGAP006893-PA n=3 Tax=Culicidae RepID=A7URX1_ANOGA
          Length = 374

 Score =  110 bits (274), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 4/102 (3%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE + E+L       GAFL+R+S T+ GC++LS+R+  PA   ++ HY I R
Sbjct: 254 PWFQAGIPREISLEVL--SRQNPGAFLVRQSTTKPGCFALSLRVPPPA--PKVAHYLILR 309

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
              G+        F SL AL+ H+S + + +  PL  P   Q
Sbjct: 310 TIRGYKIKGFTKEFTSLRALITHHSVMPELLPVPLALPRPPQ 351


>UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS
          Length = 938

 Score =  109 bits (273), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 40/154 (25%), Positives = 69/154 (44%), Gaps = 27/154 (17%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE A++LL   G   G FL+RES T  G + LS+        + + HY+++R 
Sbjct: 9   WFHANLSREAADDLLR-QGYEDGTFLVRESSTAAGDFVLSILCQ-----EEVCHYQVRRH 62

Query: 153 -DNGWLYISPR---LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
            ++ +  I           L  LV++Y + A+G+   L  P +         +D PP  T
Sbjct: 63  GEDAFFSIDDEMQTKILHGLETLVDYYQQGANGLPTKLTVPLI---------RDPPPHNT 113

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
                   ++   + L   A +  E+ ++ E L+
Sbjct: 114 --------RRHGMTNLLHRATSKNESKVVFELLK 139



 Score = 70.5 bits (171), Expect = 6e-11,   Method: Composition-based stats.
 Identities = 26/144 (18%), Positives = 52/144 (36%), Gaps = 26/144 (18%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNP----------GGAFLIRESQTRRGCYSLSVRLSRP 138
               W +   +R++A   L                 G FL+R S++     + S  +   
Sbjct: 282 TREQWYHGTQTRDEAVATLTQYAKELLAKQPGVDTSGCFLVRYSESP----AASGLVLTL 337

Query: 139 ASWDRIRHYRI------------QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
            S   ++++RI            Q  +  +++I     +PSL  L+ ++   + G+   L
Sbjct: 338 LSDQVVKNFRISQAYLYTNGVKVQSDEQKFVFIDDGPYWPSLEHLIANFMRFSYGLPVSL 397

Query: 187 REPCVLQKLGPLPGKDTPPPVTVP 210
           +     +    +P   T P  TV 
Sbjct: 398 KYAVPPKPKPEVPSFATIPRSTVK 421


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 31/104 (29%), Positives = 46/104 (44%), Gaps = 6/104 (5%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W + GL+R++   L    G   G FLIRESQ   G + LS   +      +++HY+I
Sbjct: 657 TQPWFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSFSHN-----QKVKHYQI 711

Query: 150 QRLDNGWLYISP-RLTFPSLHALVEHYSELADGICCPLREPCVL 192
             +++G   I      F  L  LVE Y   + G+   L   C  
Sbjct: 712 NMVEDGVYTIDDGGTRFTDLIQLVEFYQLNSGGLPTRLLHICTK 755


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 38/147 (25%), Positives = 65/147 (44%), Gaps = 21/147 (14%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGN 112
           ++ E L I +E  D ++++ + S   +   +         W    + R +AEE+L   G 
Sbjct: 591 KINEWLGIKNEADDSYSLEEDESSPHHDEST---------WYVGDIKRSQAEEMLR--GT 639

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             G FLIRESQT++G Y+ SV +         +H  + +   G+ +  P   + SL  LV
Sbjct: 640 CDGTFLIRESQTQKGSYACSVVVDGDT-----KHCVVYKTVTGYGFAEPYNLYSSLKDLV 694

Query: 173 EHYS-----ELADGICCPLREPCVLQK 194
            HY      +  D +   L  P + + 
Sbjct: 695 LHYKNVSLVQHNDHLNVTLAHPVLARS 721



 Score = 71.6 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 28/109 (25%), Positives = 45/109 (41%), Gaps = 14/109 (12%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR-RGCYSLSVRLSRPASWDRIRHYRIQ 150
            W +  +SRE+  E L     P G FL+R++ ++  G Y+L++R        +I H    
Sbjct: 361 EWYWGEISREEVNEKLR--DTPDGTFLVRDASSKLEGEYTLTLRKGGNNKLIKIYH---- 414

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADG-----ICCPLREPCVLQK 194
               G    S  LTF S+  L+ HY   +       +   L  P    +
Sbjct: 415 --REGRYGFSEPLTFLSVVELINHYRHESLAQYNAKLDTKLLYPVSKYQ 461


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 42/169 (24%), Positives = 73/169 (43%), Gaps = 28/169 (16%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSRE A+ELL   G   G FL+RES T  G + LS+          + HY+++R 
Sbjct: 10  WYHGNLSREAADELL-KQGYEDGTFLVRESSTAAGDFVLSLLCQ-----GEVCHYQVRRH 63

Query: 153 --DNGWLYISPR---LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
             ++ +  I  +        L  LV++Y + A+G+   L  P +         +D PP  
Sbjct: 64  GGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLI---------RDLPPHN 114

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPL 256
           T        +    + L   A +  E+ ++ E L+    ++ +  +D  
Sbjct: 115 T--------RSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQ 155



 Score = 86.3 bits (212), Expect = 8e-16,   Method: Composition-based stats.
 Identities = 31/151 (20%), Positives = 58/151 (38%), Gaps = 31/151 (20%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNP----------GGAFLIRESQTRRGCYSLSVRLS 136
                 W +  L+RE+A  +L                 G FL+R S++     + S  + 
Sbjct: 282 NTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESP----AASGLVL 337

Query: 137 RPASWDRIRHYRIQRLD------------NGWLYISPRLTFPSLHALVEHYSELADGICC 184
                  ++++RI + D            + +LYI     +PS+  L+ H+   + G+  
Sbjct: 338 TLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPV 397

Query: 185 PLREPCVLQKLGPLPGKDTPPPVTVPTSSLN 215
            L+ P       P P  + P   T+P S++ 
Sbjct: 398 SLKYPVP-----PQPKPEVPSFATIPRSNMK 423


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 40/143 (27%), Positives = 60/143 (41%), Gaps = 21/143 (14%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGN 112
           ++ E L I +E  D + +  +     +H            W    ++R +AEE+L   G 
Sbjct: 590 KINEWLGIKNETEDQYALMEDEDDLPHHEERT--------WYVGKINRTQAEEML--SGK 639

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             G FLIRES ++RGCY+ SV +         +H  I R   G+ +  P   + SL  LV
Sbjct: 640 RDGTFLIRES-SQRGCYACSVVVDGDT-----KHCVIYRTATGFGFAEPYNLYGSLKELV 693

Query: 173 EHYSE-----LADGICCPLREPC 190
            HY         D +   L  P 
Sbjct: 694 LHYQHASLVQHNDALTVTLAHPV 716



 Score = 79.7 bits (195), Expect = 9e-14,   Method: Composition-based stats.
 Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 14/137 (10%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR-RGCYSLSVRLSRPASWDRIRHYRIQ 150
            W +  +SRE+  E L     P G FL+R++ ++ +G Y+L++R        ++ H    
Sbjct: 329 EWYWGDISREEVNEKLR--DTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH---- 382

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADG-----ICCPLREPCVLQKLGPLPGKDTPP 205
              +G    S  LTF S+  L+ HY   +       +   L  P    +   +  +D+  
Sbjct: 383 --RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVE 440

Query: 206 PVTVPTSSLNWKKLDRS 222
            V       + +  D+S
Sbjct: 441 AVGAQLKVYHQQYQDKS 457


>UniRef50_Q9VRS2 CG32406 n=13 Tax=Drosophila RepID=Q9VRS2_DROME
          Length = 474

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 3/97 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+SR+ A E+L       GAFL+R+S ++ GCY+L++R+  P    +I +Y I R 
Sbjct: 342 WYQAGISRDIAVEVL--QSKSPGAFLVRKSSSKPGCYALTLRVPSPP-GPKIANYIILRS 398

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
             G+     R  F SL AL+ H+S + + +  PL  P
Sbjct: 399 PRGYKIKGFRKEFSSLKALITHHSVMPELLPVPLAMP 435


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 41/173 (23%), Positives = 75/173 (43%), Gaps = 28/173 (16%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            +  W +  LSRE A++LL   G   G FL+RES T  G + LS+        + + HY+
Sbjct: 6   ESMKWFHGNLSREAADDLL-KQGYEDGTFLVRESSTAAGDFVLSLLCQ-----EEVCHYQ 59

Query: 149 IQRL--DNGWLYISPR---LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           ++R   ++ +  I  +        L  LV++Y + A+G+   L  P +         +D 
Sbjct: 60  VRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLI---------RDP 110

Query: 204 PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPL 256
           PP  T        +    + L   A +  E+ ++ E L+    ++ +  +D  
Sbjct: 111 PPHNT--------RSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQ 155



 Score = 81.6 bits (200), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 33/152 (21%), Positives = 57/152 (37%), Gaps = 33/152 (21%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNP----------GGAFLIRESQTRRGC-YSLSVRL 135
                 W +   SRE+A   L                 G FL+R S++       L++  
Sbjct: 282 NTTREQWYHGTQSREEAVANLKKFAKELESKNPQIDTSGCFLVRYSESAAATGLVLTLFC 341

Query: 136 SRPASWDRIRHYRIQRLD------------NGWLYISPRLTFPSLHALVEHYSELADGIC 183
            + A     +++RI + D            + +LYI     +PSL  L+ H+   + G+ 
Sbjct: 342 DQVA-----KNFRISQADLYQNGVKLQSGGSKFLYIDDGPYWPSLEHLIAHFMRFSYGLP 396

Query: 184 CPLREPCVLQKLGPLPGKDTPPPVTVPTSSLN 215
             L+ P       PLP  + P   T+P + + 
Sbjct: 397 VSLKYPVP-----PLPKPEVPSFATIPRALVK 423


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 38/155 (24%), Positives = 63/155 (40%), Gaps = 18/155 (11%)

Query: 46  EQARLSLRLGEPLTIISE------DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS 99
            +  L L  GE    +SE      + +    +      E   P +        W +  ++
Sbjct: 61  TEEFLDLYGGEKFATLSELVTYYMENEGQLREKNGDLIELKYPLISEDPTTERWFHGKIT 120

Query: 100 REKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYI 159
            ++AE++LL  G P   FL+RES  R G Y LSV      + +++ H  I    NG   +
Sbjct: 121 GKEAEKMLLERGKPD-CFLVRESVHRPGSYVLSVL-----TGEQVAHIMIHGKPNGMYDV 174

Query: 160 SPRLTFPSLHALVEHYSELA-----DGICCPLREP 189
                F SL  L++ Y+         G+   L++P
Sbjct: 175 GGGHQFSSLKELIDFYTNTPMVEKNGGLVS-LKQP 208



 Score = 85.1 bits (209), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 45/91 (49%), Gaps = 7/91 (7%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  L+  +AE+LL L G   G+FL R S +  G ++LSVR       D + H RIQ 
Sbjct: 7   RWFHHNLTGLEAEKLLTLKG-VSGSFLARPSHSTPGSFTLSVR-----RGDEVTHIRIQN 60

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGI 182
            +  +L +     F +L  LV +Y E    +
Sbjct: 61  TEE-FLDLYGGEKFATLSELVTYYMENEGQL 90


>UniRef50_Q7Q480 AGAP008273-PA (Fragment) n=3 Tax=Culicidae RepID=Q7Q480_ANOGA
          Length = 291

 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 35/98 (35%), Positives = 53/98 (54%), Gaps = 3/98 (3%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   GL RE + E+L       GAFL+R S T+ GC++LS+R+  P S  ++ HY I +
Sbjct: 162 SWFQAGLPRELSLEVLTQQS--PGAFLVRRSTTKHGCFALSLRVP-PGSGPKVVHYLIMK 218

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            + G+        F SL AL+ H+S + + +  PL  P
Sbjct: 219 TERGYKIKGFTKEFSSLRALITHHSVMPEMLPVPLSLP 256


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 36/165 (21%), Positives = 71/165 (43%), Gaps = 19/165 (11%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISEDGD-WWTVQSEVSGREYH 80
                +P   K   VA+  +        LS + G+   + ++ GD W  V +  +G +  
Sbjct: 166 PTPPPEPVNDKKRIVAILPYTKMPDTDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGL 225

Query: 81  MPSVYVAKVAH--------GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           +    V  +           W +  +++ +A ++L+  G   G+FL+R S    G YSL 
Sbjct: 226 IFRELVDDLDDSIDPNTVFSWFHPNVTKSEAVDMLVKAG--PGSFLVRPSDNSPGDYSLF 283

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
             ++     ++I+ +RI++   G  Y+    TF  L A++  Y +
Sbjct: 284 FHIN-----NQIQRFRIEK--KGVRYLMGGRTFECLDAVINRYRK 321



 Score = 88.6 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 39/152 (25%), Positives = 56/152 (36%), Gaps = 18/152 (11%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           + + A   + W +  L R  AEE L       G++L+RES  + G Y LS          
Sbjct: 67  TTFSAPPENQWYHGRLDRFTAEERLRDASR-LGSYLVRESDRKPGSYVLSYL-----GRT 120

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCVLQKLGPLPGK 201
            I H+RI  +  G  YI     F SL  LV +Y+  +D +    L  P       P P  
Sbjct: 121 GINHFRITAVC-GDYYIG-GRQFNSLMDLVAYYTHCSDLLKKERLIHPTPP----PEPVN 174

Query: 202 DTP-----PPVTVPTSSLNWKKLDRSLLFLEA 228
           D        P T    +         + F+  
Sbjct: 175 DKKRIVAILPYTKMPDTDELSFQKGDIFFVHN 206


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  107 bits (267), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 38/164 (23%), Positives = 62/164 (37%), Gaps = 17/164 (10%)

Query: 55  GEPLTIISE------DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL 108
           GE    ++E      +      +      E   P       +  W +  LS ++AE+LL 
Sbjct: 68  GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLT 127

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRP-----ASWDRIRHYRIQRLDNGWLYISPRL 163
             G   G+FL+RESQ+  G + LSVR             ++ H  I+  +     +    
Sbjct: 128 EKGK-HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQEL-KYDVGGGE 185

Query: 164 TFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDT 203
            F SL  LVEHY +       G    L++P    ++     +  
Sbjct: 186 RFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESR 229



 Score = 88.6 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 49/108 (45%), Gaps = 13/108 (12%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  ++  +AE LLL  G   G+FL R S++  G ++LSVR         + H 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVR-----RNGAVTHI 54

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSEL------ADGICCPLREP 189
           +IQ   + +  +     F +L  LV++Y E        +G    L+ P
Sbjct: 55  KIQNTGD-YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP 101


>UniRef50_C4Q5Y9 Tensin-related n=1 Tax=Schistosoma mansoni RepID=C4Q5Y9_SCHMA
          Length = 1117

 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 2/98 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W    L RE A ELL       G+FL+R S T  GC +LSVR+    +   I HY IQ+
Sbjct: 790 PWFQAMLPREIAFELLAKE--EVGSFLVRNSATHPGCCALSVRVPNKDNPIGITHYLIQK 847

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            + G         +PSL ALV H + + + + CPL+ P
Sbjct: 848 TNRGVRLKGLDKEWPSLQALVTHLTVIPEMLPCPLKLP 885


>UniRef50_P52735 Guanine nucleotide exchange factor VAV2 n=43 Tax=Euteleostomi
           RepID=VAV2_HUMAN
          Length = 878

 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 45/208 (21%), Positives = 84/208 (40%), Gaps = 42/208 (20%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD- 66
              +    S +GP  + V+MQ   H   A      P G+   L+ + G+ L ++  D + 
Sbjct: 575 TSPADLDASGAGPGPKMVAMQ-NYHGNPA------PPGKPV-LTFQTGDVLELLRGDPES 626

Query: 67  -WWTVQSEVSGREYHMPSVYVAK-------------------VAHGWLYEGLSREKAEEL 106
            WW  +   + +  + PS  V                      A+ W    + R++ + L
Sbjct: 627 PWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNL 686

Query: 107 LLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFP 166
           L    +  G +LIRE       +++S++ +     D ++H ++   DN W++I+    F 
Sbjct: 687 L--KSHASGTYLIRERPAEAERFAISIKFN-----DEVKHIKVVEKDN-WIHITEAKKFD 738

Query: 167 SLHALVEHYSELADG-----ICCPLREP 189
           SL  LVE+Y   +       +   L+ P
Sbjct: 739 SLLELVEYYQCHSLKESFKQLDTTLKYP 766



 Score = 55.8 bits (133), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 28/76 (36%), Positives = 36/76 (47%), Gaps = 5/76 (6%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSE 73
           S GP     S+   R   TAVA  +F A +   LSLR G+ + I S    D  WW  + E
Sbjct: 802 SQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWW--KGE 859

Query: 74  VSGREYHMPSVYVAKV 89
            +GR    PS YV + 
Sbjct: 860 TNGRIGWFPSTYVEEE 875


>UniRef50_Q6NR09 CG33993 n=13 Tax=Diptera RepID=Q6NR09_DROME
          Length = 421

 Score =  106 bits (265), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 35/98 (35%), Positives = 52/98 (53%), Gaps = 4/98 (4%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE + E L       GAFL+R+S T+ GC++LS+R+  P+   R+ HY I R
Sbjct: 285 AWFQAGIPREISLEALSRQS--PGAFLVRQSSTKPGCFALSLRVPPPS--PRVAHYLILR 340

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
              G+        F SL AL+ H+S + + +  PL  P
Sbjct: 341 TQRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLP 378


>UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleostomi
           RepID=ZAP70_HUMAN
          Length = 619

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 39/110 (35%), Positives = 50/110 (45%), Gaps = 6/110 (5%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            + Y  +SR +AEE L L G   G FL+R+     G Y LS+         R  H+ I+R
Sbjct: 9   PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV-----RFHHFPIER 63

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK-LGPLPG 200
             NG   I+          L E YS   DG+ C LR+PC     L P PG
Sbjct: 64  QLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPG 113



 Score = 99.4 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 44/224 (19%), Positives = 73/224 (32%), Gaps = 61/224 (27%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  L+RE+AE  L       G FL+R  + + G Y+LS+          + HY I 
Sbjct: 161 MPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIY-----GKTVYHYLIS 214

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKL--------------- 195
           +   G   I     F +L  LVE+    ADG+   L+E C                    
Sbjct: 215 QDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHP 274

Query: 196 ------------------GPLPGKDTPPPVTVP---------TSSLNWKKLDRSLLFLE- 227
                              P P + T P    P         +   + ++L    LFL+ 
Sbjct: 275 STLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKR 334

Query: 228 --------APASGEASLLSEGL----RESLSSYISLAEDPLDDA 259
                       G    + +G+    ++ +   I + +   + A
Sbjct: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA 378


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 7/103 (6%)

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R +AE  +   GN  G FLIR+S +  G Y LSV     A      H++I+   
Sbjct: 6   FHGSVPRAEAEAKVQRGGN--GVFLIRQSSSDSGSYVLSVGYQGEA-----LHFKIKNEG 58

Query: 154 NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
             W  I     F  L  L EH+    DG+ C L  P +++   
Sbjct: 59  ECWFSIDEGPVFEGLADLTEHFVHFPDGLPCNLTSPVLVRSAE 101



 Score = 94.7 bits (234), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 59/310 (19%), Positives = 100/310 (32%), Gaps = 86/310 (27%)

Query: 24  PVSMQPERHKVTAVALG-SFPAGEQARLSLRLGE-PLTIISEDGDWWTVQSEVSGREYH- 80
           P+ +  ER     V L  S+  G    +    GE P  + S  G+  T +      E + 
Sbjct: 179 PLHLLAERGTAEIVLLLISY--GADVTVINNDGETPRQVASRVGNTQTCRVLSDSEEGYG 236

Query: 81  MPSVYVAKVAH-GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
           +P   + K+    + +  L+R  AE ++ + G+  G FL+R S+   G + LS+  ++  
Sbjct: 237 VP--EIKKLFELEYYHGKLNRVAAENIITIYGSNDGLFLVRFSKGS-GNFILSMCFNQSC 293

Query: 140 SWDRIRHYRIQR-LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC-------- 190
                 H++IQ        +I     F SL  L++HY   +DG+ C L   C        
Sbjct: 294 F-----HFQIQCSQAENCYFIDDGPGFTSLGDLIQHYRLKSDGLPCVLTRFCKRSARSGG 348

Query: 191 ------------------------------------------VLQKLGPLPGKDTPPPVT 208
                                                       + +   P  DTP P  
Sbjct: 349 LSPDEEDIYQTGNLKAKKPRSKPVRASTYEEPGKKIPPARPKKKKSMQSRPLPDTPQPQQ 408

Query: 209 VPTSSLNWKKLD---------------------RSLLFLEAPASGEASLLSEGLRESLSS 247
                    +LD                       +   +   +GE   +  G  +S + 
Sbjct: 409 SKDDYDKMAELDELMKRQELVGVKPGKLNSIPYHDIELGDELGAGEFGKVYRGTYKSAAG 468

Query: 248 YISLAEDPLD 257
            IS+A   L 
Sbjct: 469 SISVAVKTLQ 478


>UniRef50_Q9UKW4 Guanine nucleotide exchange factor VAV3 n=112 Tax=Euteleostomi
           RepID=VAV3_HUMAN
          Length = 847

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 46/211 (21%), Positives = 84/211 (39%), Gaps = 31/211 (14%)

Query: 2   GSLSS--RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPA----GEQARLSLRLG 55
           G ++S  +G    P   ++G  + P  + P   K+  +   S        E   L L+ G
Sbjct: 563 GRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAG 622

Query: 56  EPLTIISEDGD--WWTVQSEVSGREYHMPSVYVAK----------VAHGWLYEGLSREKA 103
           + + ++  D    +W  ++  SG     PS  V                W    + R +A
Sbjct: 623 DTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQA 682

Query: 104 EELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRL 163
           E  L+   N    +L+R      G Y++S++ +  A     +H +I    +G+ +I+   
Sbjct: 683 ETELINRVNS--TYLVRHRTKESGEYAISIKYNNEA-----KHIKIL-TRDGFFHIAENR 734

Query: 164 TFPSLHALVEHYSELA--DG---ICCPLREP 189
            F SL  LVE+Y   +  +G   +   L+ P
Sbjct: 735 KFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 765



 Score = 53.1 bits (126), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 23/82 (28%), Positives = 34/82 (41%), Gaps = 5/82 (6%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE--DGD 66
           K    S    G       + P+     A+A   F A +   LSL  G+ + I ++     
Sbjct: 767 KEPEHSAGQRGNRAGNSLLSPKVLG-IAIARYDFCARDMRELSLLKGDVVKIYTKMSANG 825

Query: 67  WWTVQSEVSGREYHMPSVYVAK 88
           WW  + EV+GR    PS YV +
Sbjct: 826 WW--RGEVNGRVGWFPSTYVEE 845


>UniRef50_A7T8K3 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T8K3_NEMVE
          Length = 402

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 5/110 (4%)

Query: 77  REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
           +  ++   Y       W   G+ RE   E+L       G+F +R+SQ++ GC++L+VR+ 
Sbjct: 257 QGMYIVYDY---QNECWYMPGIPREFIMEMLQAS--EEGSFFVRDSQSKPGCHALTVRVP 311

Query: 137 RPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
                    +Y I  +  G        TF  L +L+E+YS  ADG+ C L
Sbjct: 312 TEVHASGFGNYLITPIPEGVKLEGFSRTFTDLVSLIEYYSYHADGLPCRL 361


>UniRef50_Q380D8 AGAP001259-PA (Fragment) n=3 Tax=Culicidae RepID=Q380D8_ANOGA
          Length = 264

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 37/113 (32%), Positives = 56/113 (49%), Gaps = 4/113 (3%)

Query: 78  EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           +      Y   +   W +E L R  + +LL       G+FL+R+S T+  CY+LS+R+  
Sbjct: 127 DLEQEREYRRLLDECWYHENLPRSLSLQLL--ADKLPGSFLVRKSTTQPDCYALSLRVP- 183

Query: 138 PASWDRIRHYRIQRLD-NGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           P S  RI HY I R    G+     +  F SL AL+ H+S + + +  PL  P
Sbjct: 184 PGSGPRIAHYLIVRTSTEGYKIKGFQKEFSSLRALIVHHSVMPEALPVPLAVP 236


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score =  104 bits (259), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 43/196 (21%), Positives = 78/196 (39%), Gaps = 31/196 (15%)

Query: 20  PDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS----------EDGDWWT 69
           P Q   S+ P    V +V+  S  A      S R G    II           E+G  W 
Sbjct: 424 PQQRKSSLPPFSAPVRSVSENSLVAM---DFSGRTG---RIIDNPVEAQSAALEEGQTWR 477

Query: 70  VQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +S+          ++ + ++        W +  + RE+A ++++  G   G FL+R+SQ
Sbjct: 478 KRSQRMNVLGSPSPMHPSSLSAAIHRTQVWFHGRIVREEAHKMIIQQGQVDGLFLLRDSQ 537

Query: 124 TRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNGWLYI---SPRLTFPSLHALVEHYSELA 179
           +    + L++         +I+H++I    ++G ++         F  L  LV+ Y    
Sbjct: 538 SNPRAFVLTL-----CHHQKIKHFQILPCEEDGQVFFSLDDGSTKFTDLIHLVDFYQLNR 592

Query: 180 DGICCPLREPCVLQKL 195
             + C L+ PC    L
Sbjct: 593 GVLPCKLKHPCTAVAL 608


>UniRef50_A7RU23 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RU23_NEMVE
          Length = 814

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 5/110 (4%)

Query: 77  REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
           +  ++   Y       W   G+ RE   E+L       G+F +R+SQ++ GC++L+VR+ 
Sbjct: 669 QGMYIVYDY---QNEYWYMPGIPREFIMEMLQAS--EEGSFFVRDSQSKPGCHALTVRVP 723

Query: 137 RPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
                    +Y I  +  G        TF  L +L+E+YS  ADG+ C L
Sbjct: 724 TEVHASGFGNYLITPIPEGVKLEGFSRTFTDLVSLIEYYSYHADGLPCRL 773


>UniRef50_Q5BXE5 SJCHGC04002 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BXE5_SCHJA
          Length = 240

 Score =  103 bits (258), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 41/153 (26%), Positives = 60/153 (39%), Gaps = 9/153 (5%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W    L RE A ELL       G+FL+R S T  GC +LSVR+    +   I HY IQ+
Sbjct: 85  PWYQALLPREIAFELLARE--EVGSFLVRNSATHPGCCALSVRVPNKDNPLGITHYLIQK 142

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE------PCVLQKLGPLPGKDTPP 205
              G         +PSL ALV H + + + + CPL+       P +  +       D   
Sbjct: 143 TSQGVRLKGLDKEWPSLQALVTHLTVIPEMLPCPLKLSQYTANP-IFTQFDLQLTNDPSK 201

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLS 238
            +T    + N +     +       +   S   
Sbjct: 202 EITGQQRNYNIRLSRTEVGDNNRITNSNLSSHH 234


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  103 bits (257), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 11/101 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LS ++AE L+L  G   G+FL+RESQ++ G + LSVR     + D++ H  I+  
Sbjct: 58  WFHGNLSGKEAERLILERGK-NGSFLVRESQSKPGDFVLSVR-----TEDKVTHVMIRWH 111

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELA----DGICCPLREP 189
           +N    +     F +L  L+EHY         G    LR+P
Sbjct: 112 EN-KYDVGGGQKFGTLCELIEHYKRNPMVEICGTVVHLRQP 151


>UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3XYL7_BRAFL
          Length = 296

 Score =  103 bits (257), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W    + RE A   L       GAF++RES +  GCY+LS+R     +   I +Y I +
Sbjct: 197 AWYKGNVPREMAMAEL--ERQCAGAFMVRESGSNPGCYALSLR-----TMAGISNYLIGK 249

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            D G+  +    +FP LH L+ HYS  A+ + C LR
Sbjct: 250 TDKGYTIMGFGKSFPDLHTLIIHYSVYAEMLPCRLR 285


>UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RJ03_TRIAD
          Length = 235

 Score =  103 bits (257), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 41/105 (39%), Positives = 58/105 (55%), Gaps = 10/105 (9%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                GW + GLSR   +++L    N  G+F +R S T  G +SLSV+        RI H
Sbjct: 10  QDQFDGWFFTGLSRGDIDKMLYKKVNQQGSFAVRPSDTYLGDFSLSVKD-----GKRICH 64

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
           Y I+RL +G   IS R+TFPSL +LV +Y +  +G+     +PCV
Sbjct: 65  YLIRRLCSGHFLISVRVTFPSLLSLVTYYVDDNNGL-----KPCV 104



 Score = 90.5 bits (223), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 34/103 (33%), Positives = 58/103 (56%), Gaps = 7/103 (6%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPG-GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
           +   + Y  + R  AE+LLL     G   FLIR+S++ +G ++LSV+ +     D I H+
Sbjct: 134 LFQPYYYGEMKRADAEKLLLSESVDGCNLFLIRKSESYKGEFALSVKEN-----DDILHF 188

Query: 148 RIQRLDNGWLYISPR-LTFPSLHALVEHYSELADGICCPLREP 189
           R+  L    L I+ + + F SL  LV+++S  ++G+C  L +P
Sbjct: 189 RLPELQQDSLIIARKYIEFISLDDLVQYFSLNSNGLCAKLTKP 231


>UniRef50_Q8WPV5 Tyrosine kinase n=4 Tax=Eumetazoa RepID=Q8WPV5_SCHMA
          Length = 1264

 Score =  103 bits (257), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 7/99 (7%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  + R +AE  L   GN  GAFL+R  +  R  Y LS+           +HYRI+
Sbjct: 200 QPWYHHTIRRYEAESRLASEGNQDGAFLVRYRKEDR-TYVLSLTSQNEP-----KHYRIE 253

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
              + W  I     F ++  L++HY    DG+ C L++P
Sbjct: 254 EYLSRW-SIEGGQYFETIMELIDHYHFRQDGLLCKLQKP 291



 Score = 88.6 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 33/106 (31%), Positives = 48/106 (45%), Gaps = 11/106 (10%)

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            Y  ++RE+AEELL   G   G FL+RES  R   Y++S+         R+ HY ++R  
Sbjct: 50  FYGKITREQAEELLFTNGANEGLFLLRESVNRN--YAVSI-----CHLGRVHHYNVERHT 102

Query: 154 NGWLYISPRLTFPSLHALVEHYSELADGICC----PLREPCVLQKL 195
           +    I     F     LV+H+S   DG       PL  P  +  +
Sbjct: 103 DCSYRIQTGHKFIGPVELVQHHSTQLDGFLTLAQLPLNRPVGMSPI 148


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score =  103 bits (256), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 28/174 (16%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
           + K S P  +S   D      +      + A    ++ A  +  LSL  G          
Sbjct: 17  KRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKG---------- 66

Query: 66  DWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
                    +  +Y  PS+      + W Y  ++R +AE  L   G+  G FLIR+S++ 
Sbjct: 67  ---------TKCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHE-GDFLIRDSESS 116

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
              +S+S++          +H+++Q  +   +Y   +  F ++  LVEHY +  
Sbjct: 117 PNDFSVSLKAQGKN-----KHFKVQLKET--VYCIGQRKFSTMEELVEHYKKAP 163


>UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=Euteleostomi
           RepID=Q5SUW3_MOUSE
          Length = 550

 Score =  103 bits (256), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 41/191 (21%), Positives = 76/191 (39%), Gaps = 17/191 (8%)

Query: 15  PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSE- 73
           P   G      +      + + VA+  F +G+  R+     E  +   E+G  W  +S  
Sbjct: 367 PQRKGLPPPFNAPMRSVSENSLVAM-DF-SGQIGRVIDNPAEAQSAALEEGHAWRKRSTR 424

Query: 74  ---VSGREYHMPS--VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC 128
              +S +    PS    V      W +  +SRE++  ++   G   G FL+R+SQ+    
Sbjct: 425 MNILSSQSPLHPSTLNAVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKA 484

Query: 129 YSLSVRLSRPASWDRIRHYRIQ-RLDNGWLYI---SPRLTFPSLHALVEHYSELADGICC 184
           + L++         +I++++I    D+G  +         F  L  LV+ Y      + C
Sbjct: 485 FVLTL-----CHHQKIKNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPC 539

Query: 185 PLREPCVLQKL 195
            L+  C+   L
Sbjct: 540 KLKHHCIRVAL 550


>UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=Euteleostomi
           RepID=GRB7_HUMAN
          Length = 532

 Score =  103 bits (256), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 45/197 (22%), Positives = 74/197 (37%), Gaps = 20/197 (10%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           + ++    PS  G               T VA+  F +G   R+     E L++  E+  
Sbjct: 348 QAQSRHLHPSCLGS-----PPLRSASDNTLVAM-DF-SGHAGRVIENPREALSVALEEAQ 400

Query: 67  WWTVQ-SEVSGREYHMPSVYVAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRES 122
            W  + +             ++   H    W +  +SRE+++ L+   G   G FL+RES
Sbjct: 401 AWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRES 460

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRL-DNGWLYI---SPRLTFPSLHALVEHYSEL 178
           Q     + LS+         +++HY I    + G LY      +  F  L  LVE +   
Sbjct: 461 QRNPQGFVLSL-----CHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515

Query: 179 ADGICCPLREPCVLQKL 195
              + C LR  C    L
Sbjct: 516 RGILPCLLRHCCTRVAL 532


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 35/185 (18%), Positives = 74/185 (40%), Gaps = 21/185 (11%)

Query: 26  SMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPS 83
             +P   +    A+  +        +S   G+   + +E +  W  V +  +  +  +  
Sbjct: 274 PPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVE 333

Query: 84  VYVAKVAHG--------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
             V +V           W +  +S+++A  LL+  G    +FL+R S    G YSL  R 
Sbjct: 334 DLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYFR- 391

Query: 136 SRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA--DGICCPLREPCVLQ 193
               + + I+ ++I    N   ++     + S+  +++HY +    +G    L+EP  +Q
Sbjct: 392 ----TNENIQRFKICPTPNNQ-FMMGGRYYNSIGDIIDHYRKEQIVEGY--YLKEPVPMQ 444

Query: 194 KLGPL 198
               +
Sbjct: 445 DQEQV 449



 Score = 95.9 bits (237), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 38/128 (29%), Positives = 54/128 (42%), Gaps = 12/128 (9%)

Query: 77  REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
            E  +     A   + W +  L R  AEE L   G   G++LIRES  R G + LS    
Sbjct: 165 EEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSFLSQ 223

Query: 137 RPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCVLQKL 195
                + + H+RI  +  G  YI  R  F SL  L+ +YS ++  +    L  P      
Sbjct: 224 ----MNVVNHFRIIAMC-GDYYIGGRR-FSSLSDLIGYYSHVSCLLKGEKLLYPVAP--- 274

Query: 196 GPLPGKDT 203
            P P +D 
Sbjct: 275 -PEPVEDR 281


>UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y4_9METZ
          Length = 853

 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 51/205 (24%), Positives = 85/205 (41%), Gaps = 36/205 (17%)

Query: 12  SPSPSSSGPDQEPVSMQ-----PERHKVTAVALGS--FPAGEQARLSLRLGEPLTIISED 64
            PS +++G +QE  S            V    L +  +     A  S+  G+PL I S++
Sbjct: 287 DPSEATTGAEQELPSKWTLLFTKTEDTVCFSTLLNAYYQIMVDANFSILEGDPLIIPSDE 346

Query: 65  GDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQT 124
               +   E      H+                +S +  E++L +     G FLIRES++
Sbjct: 347 MLKISENDECKAELCHV---------------AISPDSVEKVLEMYNKEDGTFLIRESRS 391

Query: 125 RRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYI---------SPRLTFPSLHALVEHY 175
               Y+LS+         RI+++RI R  +G L +          P  +FPS+ ALVEH+
Sbjct: 392 SENSYTLSL-----CHNQRIKNFRISRDTDGSLSLKDPAGSTAEQPIKSFPSMAALVEHH 446

Query: 176 SELADGICCPLREPCVLQKLGPLPG 200
               DG+   L+  C  +++    G
Sbjct: 447 KTEKDGLPTHLKINCSPKEVAKTAG 471


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 16/133 (12%)

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           +       W + GLS  +AE LLL  G   G +L+RES +  G +++SV+    A+ D++
Sbjct: 132 FSRPSTERWFHAGLSGPEAERLLLAEGK-HGTYLVRESHSSPGQFAISVK----AADDKV 186

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
            H  I    +    I    TF ++  L+EHY+            P V Q    +  K   
Sbjct: 187 IHVMIYSKSD-KFDIGGGATFSTISELLEHYTRN----------PMVDQAGTVVNLKQLL 235

Query: 205 PPVTVPTSSLNWK 217
           P   VP +S++ +
Sbjct: 236 PSTRVPATSIDIR 248



 Score = 75.1 bits (183), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 37/106 (34%), Positives = 47/106 (44%), Gaps = 17/106 (16%)

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            Y  +S   AE LL   G   G+FL R S +    Y+LSV        DRI+H +IQ   
Sbjct: 25  FYYPISGVDAERLLNTCGTE-GSFLARPSGSSPSNYTLSV-----HRGDRIKHVKIQNNG 78

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA------DG----ICCPLREP 189
           +  L +    TF SL  LV+ Y E        DG    + CPL  P
Sbjct: 79  DC-LDLYGGETFASLSELVQFYVENPGQLRERDGEIIVLKCPLVIP 123


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score =  101 bits (251), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 44/146 (30%), Positives = 63/146 (43%), Gaps = 20/146 (13%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGN 112
           RL   L I +ED D     +E                   W  E ++R +AE+LL   G 
Sbjct: 266 RLNAWLGIKNEDSDESYFINEED-------ENLPHYDEKTWFVEDINRVQAEDLLY--GK 316

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
           P GAFLIRES +++GCY+ SV      +   ++H  I     G+ +  P   + SL  LV
Sbjct: 317 PDGAFLIRES-SKKGCYACSV-----VADGEVKHCVIYSTARGYGFAEPYNLYSSLKELV 370

Query: 173 EHYSELA-----DGICCPLREPCVLQ 193
            HY + +     D +   L  P   Q
Sbjct: 371 LHYQQTSLVQHNDSLNVRLAYPVHAQ 396



 Score = 76.6 bits (187), Expect = 8e-13,   Method: Composition-based stats.
 Identities = 31/129 (24%), Positives = 52/129 (40%), Gaps = 14/129 (10%)

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRE-SQTRRGCYSLSVRLSRPASWDR 143
           +++     W +  +SRE+  + L     P G FL+R+ S   +G Y+L++R        +
Sbjct: 57  FISLQDAEWYWGDISREEVNDKLR--DMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIK 114

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG-----ICCPLREPCVLQKLGPL 198
           I H       +G    S  LTF S+  L+ HY   +       +   L  P    +   L
Sbjct: 115 IYH------RDGKYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSRFQQDQL 168

Query: 199 PGKDTPPPV 207
             +D    V
Sbjct: 169 VKEDNIDAV 177


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score =  101 bits (251), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 34/133 (25%), Positives = 58/133 (43%), Gaps = 12/133 (9%)

Query: 55  GEPLTIISEDGDWWTVQS------EVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL 108
           GE    +SE  +++T ++      + +  E   P          W +  LS   AE+LL 
Sbjct: 66  GEKFATLSELVEYYTAENGILQDKDGTIIELKYPFNCSDPTTERWYHGHLSGPNAEKLLW 125

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSV----RLSRPASWDRIRHYRIQRLDNGWLYISPRLT 164
               P G FL+RES ++ G + LSV    +    +   R+ H +I   ++    +  +  
Sbjct: 126 ERDEP-GTFLVRESLSKPGDFVLSVLTEEKSKASSGGRRVSHIKIMCQNDR-YTVGGKEM 183

Query: 165 FPSLHALVEHYSE 177
           F +L  L+EHY  
Sbjct: 184 FDTLADLMEHYKR 196



 Score = 85.5 bits (210), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 41/174 (23%), Positives = 67/174 (38%), Gaps = 25/174 (14%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +S   AE +L   G   G+FL R S+  +G +SLSVR+      + + H RIQ 
Sbjct: 3   RWFHRDISGLDAESVLKSRG-VHGSFLARPSRKNQGDFSLSVRV-----GELVTHIRIQN 56

Query: 152 LDNGWLYISPRLTFPSLHALVEHYS------ELADGICCPLREPCVLQKLGPLPGKDTPP 205
             + +  +     F +L  LVE+Y+      +  DG    L+ P            +   
Sbjct: 57  TGD-FYDLYGGEKFATLSELVEYYTAENGILQDKDGTIIELKYP-----------FNCSD 104

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
           P T      +    +   L  E    G   L+ E L +     +S+  +    A
Sbjct: 105 PTTERWYHGHLSGPNAEKLLWERDEPGTF-LVRESLSKPGDFVLSVLTEEKSKA 157


>UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax=Euteleostomi
           RepID=GRB10_HUMAN
          Length = 594

 Score =  100 bits (250), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 29/143 (20%), Positives = 59/143 (41%), Gaps = 15/143 (10%)

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGA 116
           E+G  W  +S           ++ + ++        W +  +SRE++  ++   G   G 
Sbjct: 457 EEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGL 516

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNGWLYI---SPRLTFPSLHALV 172
           FL+R+SQ+    + L++         +I++++I    D+G  +         F  L  LV
Sbjct: 517 FLLRDSQSNPKAFVLTL-----CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLV 571

Query: 173 EHYSELADGICCPLREPCVLQKL 195
           + Y      + C L+  C+   L
Sbjct: 572 DFYQLNKGVLPCKLKHHCIRVAL 594


>UniRef50_P50745 SH2B adapter protein 3 n=2 Tax=Rattus norvegicus RepID=SH2B3_RAT
          Length = 368

 Score =  100 bits (250), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 39/160 (24%), Positives = 69/160 (43%), Gaps = 18/160 (11%)

Query: 90  AHGWLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            + W +  +SR +A +L+ L G +  G FL+R+S++RRG Y L+  L       R +H R
Sbjct: 116 CYPWFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGEYVLTFNLQ-----GRAKHLR 170

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTP 204
           +   + G   +   L FPS+  ++ H+         G  C +R    +  +   PG+   
Sbjct: 171 LVLTERGQCRVQ-HLHFPSVVDMLRHFQRSPIPLECGAACDVRLSGYVVVVSQAPGRKPK 229

Query: 205 -------PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLL 237
                     T  T   +W +L   ++ + +P S    L 
Sbjct: 230 VVSRGGVTASTARTKLPSWLRLLHGVIHVISPGSSNTVLF 269


>UniRef50_B1AT95 Growth factor receptor bound protein 2 (Fragment) n=3 Tax=Eutheria
           RepID=B1AT95_MOUSE
          Length = 71

 Score =  100 bits (250), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 20/71 (28%), Positives = 38/71 (53%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAE 104
            +  + R KAE
Sbjct: 61  FFGKIPRAKAE 71


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score = 99.0 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 33/90 (36%), Positives = 53/90 (58%), Gaps = 8/90 (8%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           +  W +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR       D ++H+++
Sbjct: 29  SKRWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHE-----DDVQHFKV 81

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELA 179
            R + G  ++     FPSL+ LV++Y   +
Sbjct: 82  MRDNKGNYFLWTE-KFPSLNKLVDYYRTNS 110



 Score = 50.8 bits (120), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 3/70 (4%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYH 80
            +PV +Q       A AL  F A E   L    GE + ++   +  WWT +  +  +   
Sbjct: 236 TDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGL 293

Query: 81  MPSVYVAKVA 90
            P+ YVA + 
Sbjct: 294 FPANYVAPMT 303


>UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene vav n=1 Tax=Homo
           sapiens RepID=B4DVK9_HUMAN
          Length = 748

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 31/156 (19%), Positives = 58/156 (37%), Gaps = 24/156 (15%)

Query: 50  LSLRLGEPLTI--ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG---------WLYEGL 98
           L L  G+ + +     + +WW  ++  +      P   V    HG         W    +
Sbjct: 520 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPM 579

Query: 99  SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLY 158
            R  AE +L       G FL+R+       +++S++ +       ++H +I     G   
Sbjct: 580 ERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVE-----VKHIKIM-TAEGLYR 631

Query: 159 ISPRLTFPSLHALVEHYSELA-----DGICCPLREP 189
           I+ +  F  L  LVE Y + +       +   L+ P
Sbjct: 632 ITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 667



 Score = 53.5 bits (127), Expect = 6e-06,   Method: Composition-based stats.
 Identities = 19/56 (33%), Positives = 32/56 (57%), Gaps = 4/56 (7%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDG--DWWTVQSEVSGREYHMPSVYVAK 88
           TA A   F A +++ LSL+ G+ + I+++ G   WW  + E+ GR    P+ YV +
Sbjct: 689 TAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWW--RGEIYGRVGWFPANYVEE 742


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 37/126 (29%), Positives = 55/126 (43%), Gaps = 13/126 (10%)

Query: 92  GWLYEGLSREKAEELLLLPGNP-GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
            W +  +SR KA +L+ L G    G FL+R+S+TRRG Y L+          R +H R+ 
Sbjct: 387 PWFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLTFNFQ-----GRAKHLRLS 441

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELA----DGICC--PLREPCVLQKLGPLPGKDTP 204
             + G   +   L F S+  ++ H+         G  C   L    V+    P PG    
Sbjct: 442 LTERGQCRVQ-HLRFSSITEMLHHFHRYPIPLECGATCDVRLSSYVVVLPQAPAPGSSPA 500

Query: 205 PPVTVP 210
            PV +P
Sbjct: 501 LPVPLP 506


>UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos taurus
           RepID=UPI000179EA7A
          Length = 279

 Score = 98.2 bits (243), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 31/156 (19%), Positives = 58/156 (37%), Gaps = 24/156 (15%)

Query: 50  LSLRLGEPLTI--ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG---------WLYEGL 98
           L L  G+ + +     + +WW  ++  +      P   V    HG         W    +
Sbjct: 51  LRLNPGDIVELTKAEAEQNWWEGRNISTNEVGWFPCNRVKPYVHGPPQDLSVHLWYAGPM 110

Query: 99  SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLY 158
            R  AE +L       G FL+R+       +++S++ +       ++H +I     G   
Sbjct: 111 ERAGAESIL--TNRSDGTFLVRQRVKDAAEFAISIKYNVE-----VKHIKIM-TAEGLYR 162

Query: 159 ISPRLTFPSLHALVEHYSELA-----DGICCPLREP 189
           I+ +  F  L  LVE Y + +       +   L+ P
Sbjct: 163 ITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 198



 Score = 54.3 bits (129), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 20/56 (35%), Positives = 32/56 (57%), Gaps = 4/56 (7%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDG--DWWTVQSEVSGREYHMPSVYVAK 88
           TA A   F A +++ LSL+ G+ + I+++ G   WW  + E+ GR    PS YV +
Sbjct: 220 TAKARYDFCARDRSELSLKEGDIVKILNKKGQQGWW--RGEIYGRIGWFPSNYVEE 273


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score = 98.2 bits (243), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 40/148 (27%), Positives = 63/148 (42%), Gaps = 10/148 (6%)

Query: 81  MPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
            PS +       W +  L R  AEE L    NP G++LIRES  R G + LS      + 
Sbjct: 173 PPSNHSPPRMPRWYHGKLDRTIAEERLRQARNP-GSYLIRESDRRPGSFVLSFL----SM 227

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCVLQKLGPLP 199
            + + H+RI  +  G  YI  R  F SL  L+ +YS ++  +    L  P       P+ 
Sbjct: 228 TNVVNHFRIIAMC-GDYYIGGRR-FSSLSDLIGYYSYVSCLLKGEKLLSPVAP--PEPVE 283

Query: 200 GKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            +     +   T   +  ++ +   FL+
Sbjct: 284 DRRRVRAILPYTKVPDTDEIRQVSTFLQ 311



 Score = 80.9 bits (198), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 36/221 (16%), Positives = 72/221 (32%), Gaps = 56/221 (25%)

Query: 26  SMQPERHKVTAVALGSFPAGEQAR-----LSLRLGEPLTIISE-DGDWWTVQSEVSGREY 79
             +P   +    A+  +             +   G+   + +E D  W  V +  +  + 
Sbjct: 278 PPEPVEDRRRVRAILPYTKVPDTDEIRQVSTFLQGDMFIVHNELDDGWMWVSNVRTEEQG 337

Query: 80  HMPSVYVAKVAHG--------WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
            +    V +V           W +  +++++A  LL+  G    +FL+R S    G YSL
Sbjct: 338 LIVKDLVEEVGREEDPHEGKVWYHGHITKKEAYNLLMTVGQVC-SFLVRPSDNTPGDYSL 396

Query: 132 SVRLSRPASWDRIRHYRIQRLDNGWL------------YISPRLTF-------------- 165
             R     + D I+ ++I    N                      F              
Sbjct: 397 FFR-----TNDIIQRFKISPTSNNQYMMGGRYYNRYEPICMLGHHFQSSGYHVFSFFLRF 451

Query: 166 ------PSLHALVEHYSELA--DGICCPLREPCVLQKLGPL 198
                  S+  +++HY +    +G    L+EP  +Q+   +
Sbjct: 452 NCAASVDSVDDIIDHYKKEQIVEGY--NLKEPVSVQQQEQV 490


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 11/116 (9%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R+++EELLL      G+F++R S++R G Y+LSV  +     + +  YRI   
Sbjct: 6   WYHGRVNRQQSEELLLSAA-VDGSFVVRASESRAGAYALSVLFN-----NSVHTYRILPT 59

Query: 153 DNGWLYISP-----RLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           +N  L +       +  F SL  LV  Y    +G+ C L  P  L           
Sbjct: 60  ENNTLAVQTVNGVQQRKFKSLTELVHEYRNSQNGLVCGLSNPVGLDSKTRPSTSSA 115


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score = 96.7 bits (239), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 13/132 (9%)

Query: 90  AHGWLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            + W +  +SR KA +L+ L G +  G FL+R+S+TRRG Y L+      A     +H R
Sbjct: 368 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIA-----KHLR 422

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTP 204
           +   + G   +   L FPS+  ++ H+         G  C +R    +  +   PG    
Sbjct: 423 LSLTERGQCRVQ-HLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSSN- 480

Query: 205 PPVTVPTSSLNW 216
             V  P S  +W
Sbjct: 481 -TVLFPFSLAHW 491


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score = 96.7 bits (239), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 43/130 (33%), Positives = 56/130 (43%), Gaps = 17/130 (13%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  LSR  AE LL+      G++L+R S TR G YSLSV+       D ++H++I  
Sbjct: 13  DWYHGDLSRHMAEALLMANA-EDGSYLLRSSATRVGEYSLSVKCK-----DSVKHFQIGW 66

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELA-----DGICCPLREPCVLQKLGPLPGKDTPPP 206
             +G  Y      F SL   VEH++         GI   LR P     L P    D    
Sbjct: 67  --DGKQYQFGMGVFQSLQEFVEHFANQPLIGGESGILTALRHPYSRNVLEP----DVYDT 120

Query: 207 VTVPTSSLNW 216
           VTV  S    
Sbjct: 121 VTVHASLGQQ 130


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 45/195 (23%), Positives = 75/195 (38%), Gaps = 26/195 (13%)

Query: 56  EPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGL--SREKAEELLLLPG-N 112
           +   + S++ +    +S  +  +           +  W +  L   R KAE+LL      
Sbjct: 525 DETAVTSQEDE--EEESNDTSLQLEGLGNDEMHFSEKWFHGKLEGGRRKAEDLLKEYSYL 582

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNGW--LYISPRLTFPSLH 169
             G FL+RES T  G +SLS         D + H RI+ + + G    Y+   L F SL+
Sbjct: 583 GDGTFLVRESDTFVGDFSLSFWRK-----DSVNHCRIRSKQERGQTKYYLIDNLAFDSLY 637

Query: 170 ALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDR---SLLFL 226
           +L+ HY           + P   Q    +  +  P P +        +KLDR     +  
Sbjct: 638 SLITHYQ----------KYPLRSQDFQQILKEPVPQPQSHHGKPWYHEKLDRTRAEDMLK 687

Query: 227 EAPASGEASLLSEGL 241
             P+ G   +   G+
Sbjct: 688 RIPSDGAFLVRQNGV 702



 Score = 80.5 bits (197), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 33/149 (22%), Positives = 62/149 (41%), Gaps = 16/149 (10%)

Query: 48  ARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH---GWLYEGLSREKAE 104
             L+    + L  +      + ++S+   +    P       +H    W +E L R +AE
Sbjct: 629 DNLAF---DSLYSLITHYQKYPLRSQDFQQILKEP--VPQPQSHHGKPWYHEKLDRTRAE 683

Query: 105 ELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLT 164
           ++L    +  GAFL+R++      Y++S R     +  +I+H  I++   G L+      
Sbjct: 684 DMLKRIPS-DGAFLVRQNGVDTNSYAISFR-----AEGKIKHCIIKQ--EGRLFTIGNAQ 735

Query: 165 FPSLHALVEHYSELADGICCPLREPCVLQ 193
           F SL  LV +Y +        L+ P   +
Sbjct: 736 FESLVELVNYYEKKPLYRKMKLKHPVNEK 764



 Score = 45.8 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/75 (24%), Positives = 28/75 (37%), Gaps = 5/75 (6%)

Query: 16  SSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT-IISEDGDWWTVQSEV 74
              G    P    P+ H     AL  + A  +  LS      +T +I  D  WW      
Sbjct: 780 GGPGIYMNPNDFTPKIH---VRALYDYRAQMEDELSFCKNAIITNVIKRDEGWWLGDP-G 835

Query: 75  SGREYHMPSVYVAKV 89
           + +  + PS YV ++
Sbjct: 836 NQKRLYFPSNYVEEI 850


>UniRef50_Q8IZW8 Tensin-4 n=12 Tax=Eutheria RepID=TENS4_HUMAN
          Length = 715

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 37/134 (27%), Positives = 57/134 (42%), Gaps = 14/134 (10%)

Query: 68  WTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG 127
           +T   E   R+      +V   +  W    ++RE+A ELL       GAF+IR+S + RG
Sbjct: 424 FTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKE--EPGAFVIRDSSSYRG 481

Query: 128 CYSLSVRLS----------RPASWDRIRHYRIQRLDNGWLYI--SPRLTFPSLHALVEHY 175
            + L++++              S D IRH+ I+    G           F SL A V  +
Sbjct: 482 SFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQH 541

Query: 176 SELADGICCPLREP 189
           S +A  + C L  P
Sbjct: 542 SIMALALPCKLTIP 555


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 36/165 (21%), Positives = 65/165 (39%), Gaps = 28/165 (16%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  + R +A+ELL       G FL+RES  + G Y LSV      S  + RH+ IQ
Sbjct: 458 QDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVY-----SDGQRRHFIIQ 508

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
            +DN + +      F ++  L++H+            +  + +K G +     P      
Sbjct: 509 YVDNMYRFEGTG--FSNIPQLIDHHYT---------TKQVITKKSGVVLLNPIP------ 551

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
                W      ++  E    G    + +G L++  S  +   ++
Sbjct: 552 -KDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKE 595


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score = 94.7 bits (234), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 38/128 (29%), Positives = 56/128 (43%), Gaps = 24/128 (18%)

Query: 80  HMPSVYVAKVAHGWLYEGLS-----REKAEELL----LLPGNPGGAFLIRESQTRRGCYS 130
            + S         W +  L      R  AE LL    +  G P G+FL+RES+T  G Y+
Sbjct: 537 EVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYT 596

Query: 131 LSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTFPSLHALVEHYSELADGICC--- 184
           LS          +++H RI  R D G    +++  L F SL+ L+ HY ++   + C   
Sbjct: 597 LSFW-----RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVP--LRCNEF 649

Query: 185 --PLREPC 190
              L EP 
Sbjct: 650 EMRLSEPV 657



 Score = 80.1 bits (196), Expect = 8e-14,   Method: Composition-based stats.
 Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 9/103 (8%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
           A  +  W +  L+R +AE +L+      GAFL+R+       Y++S R     +  +I+H
Sbjct: 662 AHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVRKR-NEPNSYAISFR-----AEGKIKH 714

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
            R+Q+   G   +     F SL  L+ +Y +        LR P
Sbjct: 715 CRVQQ--EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYP 755



 Score = 42.7 bits (99), Expect = 0.013,   Method: Composition-based stats.
 Identities = 10/61 (16%), Positives = 21/61 (34%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
            K    AL  + A  +  L+      +  + +    W        ++   PS YV ++ +
Sbjct: 792 FKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVN 851

Query: 92  G 92
            
Sbjct: 852 P 852


>UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosphate 5- phosphatase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BC71
          Length = 1019

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 38/156 (24%), Positives = 64/156 (41%), Gaps = 11/156 (7%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           H W +  ++R KAEELL   G   G+FL+R S++    Y+L V        + +  YRI 
Sbjct: 3   HCWNHGNITRSKAEELLSKTGK-DGSFLVRASESISRAYALCVLY-----HNCVYTYRIL 56

Query: 151 RLDNGWLYIS-----PRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
             D+    +      P   F SL  L++ Y +   G+   L+ P  L++       +   
Sbjct: 57  PNDDEKFTVQASEGVPMRFFTSLEQLIDFYKKENMGLVTHLQYPVQLEEEDAADDPEEET 116

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL 241
              +    L  + +    +  E   +  AS  S G+
Sbjct: 117 EFIMSPPELPPRNIPLPAVLSETKETVLASDSSRGV 152


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              +++  +SRE+ + L+   G   G FL+RES    G Y+LSV      +  +++H++I
Sbjct: 27  KPPYMHGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALSV-----VAQGKLQHFKI 81

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
            R   G   I     F SL  LV+ Y    D +   L   C
Sbjct: 82  SR-KTGLYRIDDGPGFGSLDELVQFYRNPDDRLPTVLVRFC 121


>UniRef50_UPI0000EB251F Tyrosine-protein kinase Tec (EC 2.7.10.2). n=2 Tax=Euteleostomi
           RepID=UPI0000EB251F
          Length = 236

 Score = 94.4 bits (233), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 25/113 (22%), Positives = 42/113 (37%), Gaps = 11/113 (9%)

Query: 145 RHYRIQRLDN--GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           RHY I+         Y++ +  F S+  ++E++   A G+   LR P           K+
Sbjct: 1   RHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVS--------TKE 52

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
              P T   S   W+     L F+    SG   ++  G  R      I   ++
Sbjct: 53  KNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIKE 105


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score = 94.0 bits (232), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 9/112 (8%)

Query: 71  QSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
           +S  + R     +  +   A  W +  + R++A++LL       G+F++RES T  G  +
Sbjct: 547 ESANNDRRGSSDTTELH-YAEKWYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCT 605

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNG---WLYISPRLTFPSLHALVEHYSELA 179
           LS          R+ H RI    N    + Y+   L F SL++LV HY    
Sbjct: 606 LSFMY-----HGRVTHCRIHSQQNNGHTYFYLVHALLFDSLYSLVWHYQRYP 652



 Score = 77.8 bits (190), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 26/135 (19%), Positives = 59/135 (43%), Gaps = 14/135 (10%)

Query: 68  WTVQSEVSGREYHMPSVYVAKVAH---GWLYEGLSREKAEELLLLPGNPGGAFLIRESQT 124
           + +++     E  +        AH    W ++ ++R  AE +L+      GAFL+R+ ++
Sbjct: 651 YPLRNAKMNFELLLTEPVPQPNAHANKEWYHDSMTRTDAENVLMRIPR-DGAFLVRKCRS 709

Query: 125 ---RRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG 181
                  +++S R     +  +I+H RI++     L++    TF +L  ++  Y +    
Sbjct: 710 DDPSVTSFAISFR-----ADGKIKHCRIKQESR--LFVIGNATFETLCDVISFYEKNPLY 762

Query: 182 ICCPLREPCVLQKLG 196
               L+ P   +++ 
Sbjct: 763 RKMKLKHPATKEQVQ 777



 Score = 45.1 bits (105), Expect = 0.003,   Method: Composition-based stats.
 Identities = 17/62 (27%), Positives = 27/62 (43%), Gaps = 4/62 (6%)

Query: 29  PERHKVTAVALGSFPAGEQARLSLRLGEPLT-IISEDGDWWTVQSEVSGREY-HMPSVYV 86
           P    VT  AL  + A     L+      ++ +I +DG WW  + +  G+     PS YV
Sbjct: 802 PNFMSVTVKALYDYRAARDDELTFCKHAIISNVIKQDGGWW--RGDYGGKAGMWFPSNYV 859

Query: 87  AK 88
            +
Sbjct: 860 EE 861


>UniRef50_B4JFU1 GH19392 (Fragment) n=6 Tax=cellular organisms RepID=B4JFU1_DROGR
          Length = 1708

 Score = 94.0 bits (232), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 14/135 (10%)

Query: 67   WWTVQSEVSGREYHMPSVYVAK--------VAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
            + T+ S       H P+  VA          A  W    LSRE A  LLL    P G F+
Sbjct: 1410 YQTIASRQQLNSGHSPTFEVAPDLVKFARNSAKFWYKSLLSREDAIALLLNA--PPGTFV 1467

Query: 119  IRESQTRRGCYSLSVRLSRPASWDR--IRHYRIQRLDNGWLY--ISPRLTFPSLHALVEH 174
            +R+S T +  Y L +R+++P +  +  +RH+ I+    G          TF SL AL+  
Sbjct: 1468 VRDSTTYKNAYGLVLRVAQPPAGSQELVRHFLIEPTQRGVRLKGCENEPTFTSLSALIYE 1527

Query: 175  YSELADGICCPLREP 189
            +S     + C LR P
Sbjct: 1528 HSINKLALPCLLRIP 1542


>UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi RepID=SH2B3_HUMAN
          Length = 575

 Score = 94.0 bits (232), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 13/132 (9%)

Query: 90  AHGWLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            + W +  +SR KA +L+ L G +  G FL+R+S+TRRG Y L+      A     +H R
Sbjct: 361 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIA-----KHLR 415

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTP 204
           +   + G   +   L FPS+  ++ H+         G  C +R    +  +   PG    
Sbjct: 416 LSLTERGQCRVQ-HLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCN- 473

Query: 205 PPVTVPTSSLNW 216
             V  P S  +W
Sbjct: 474 -TVLFPFSLPHW 484


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score = 93.6 bits (231), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 42/155 (27%), Positives = 63/155 (40%), Gaps = 15/155 (9%)

Query: 84  VYVAKVAHGWLYEGL--SREKAEELLLLPGN-PGGAFLIRESQTRRGCYSLSVRLSRPAS 140
                 +  W +  L   R +AE LL    +   G FL+RES+T  G YSLS        
Sbjct: 586 NDELHFSEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRESETFVGDYSLSFWRQ---- 641

Query: 141 WDRIRHYRIQ-RLDNGW--LYISPRLTFPSLHALVEHYSELAD---GICCPLREPCVLQK 194
             ++ H RI+ + D G    Y+    +F SL++L+ +Y             L+EP V Q 
Sbjct: 642 -GKVNHCRIRSKQDKGQTKYYLIDTNSFDSLYSLITYYRSHPLRSQEFLIVLKEP-VPQP 699

Query: 195 LGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAP 229
                 +   P VT   +    K++     FL  P
Sbjct: 700 NKHEGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRP 734



 Score = 86.7 bits (213), Expect = 8e-16,   Method: Composition-based stats.
 Identities = 30/128 (23%), Positives = 52/128 (40%), Gaps = 13/128 (10%)

Query: 68  WTVQSEVSGREYHMPSVYVAKVAH-----GWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
           +     +  +E+ +         +      W    ++R +AEE+L       GAFL+R S
Sbjct: 677 YYRSHPLRSQEFLIVLKEPVPQPNKHEGKEWYLPNVTRSQAEEMLKRVP-TDGAFLVRPS 735

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
           +     Y++S R  +     +I+H RI+   +G LY    + F SL  L+ +Y       
Sbjct: 736 ERGANSYAISFRAEK-----KIKHCRIKV--DGRLYAIGSVYFESLVDLITYYERHPLYK 788

Query: 183 CCPLREPC 190
              L  P 
Sbjct: 789 KIRLCHPV 796



 Score = 48.9 bits (115), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 19/95 (20%), Positives = 36/95 (37%), Gaps = 9/95 (9%)

Query: 24  PVSMQPERH--KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHM 81
           P  M P     K+T  A+  + A ++  LS      +T +++    W        +++  
Sbjct: 817 PGYMDPSSFTSKITVKAIYDYQARQEDELSFCKHAIITNVNKQDRGWWRGDYGGKKQHWF 876

Query: 82  PSVYVAKVAHGWLYEGLSREKA--EELLLLPGNPG 114
           P  YV ++         +RE    E + L  G+  
Sbjct: 877 PCNYVEEIEPQE-----NREDTVRENMSLQKGSID 906


>UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein activator 1 n=1 Tax=Ciona
           intestinalis RepID=UPI000052352E
          Length = 936

 Score = 93.6 bits (231), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 30/163 (18%), Positives = 62/163 (38%), Gaps = 18/163 (11%)

Query: 26  SMQPERHKVTAVALGSFPA---GEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHM 81
             +P   +    A+  +      +   +S    +   +  + +GDW  ++S  +     +
Sbjct: 151 PPEPVDDRRRVQAILPYQKVPDADNDEISFEKDDIFIVQDDMEGDWMWLESLRTNERGCV 210

Query: 82  PSVYVAKVAH-------GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
               V  +          W + G+++E+A  LL       G+FLIR S +  G Y L   
Sbjct: 211 FRGLVRDIGDVDPHEGKEWFHAGITKEEAYSLLSAVDR-SGSFLIRVSDSTPGDYVLYFF 269

Query: 135 LSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
                +   I+ +++ R+     +      + S+  +VEHY  
Sbjct: 270 -----TGQYIQRFKLHRVGQNR-FEMGGRCYGSIDEVVEHYRH 306



 Score = 84.3 bits (207), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 36/136 (26%), Positives = 49/136 (36%), Gaps = 11/136 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  L R  AEE LL     GG +L+RESQ + G Y LS             H+RI  +
Sbjct: 58  WYHGKLDRRIAEERLLEVNVAGG-YLVRESQKKPGSYVLSFLSENIGM----THFRIISV 112

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
             G  YI     F  L  L+ +Y+  +    C L    +   + P    D    V     
Sbjct: 113 C-GDFYIG-GRQFECLEQLIAYYTHRS----CLLEGEVLRTPIQPPEPVDDRRRVQAILP 166

Query: 213 SLNWKKLDRSLLFLEA 228
                  D   +  E 
Sbjct: 167 YQKVPDADNDEISFEK 182


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 38/147 (25%), Positives = 58/147 (39%), Gaps = 46/147 (31%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
              A A   F   E++ LS +    L +                                
Sbjct: 1   MCEATAKHDFNGQEESELSFKKNSILKV-------------------------------- 28

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
                 +R+ AEELL   G   GAFLIRES+   G YSLSV+       D ++H+++ R 
Sbjct: 29  ------TRDGAEELLKNDG--DGAFLIRESEGTPGDYSLSVKF-----VDGVQHFKVLRD 75

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELA 179
             G  ++   + F SL+ LVE++   +
Sbjct: 76  GAGKYFLWV-VKFNSLNQLVEYHRTSS 101



 Score = 62.8 bits (151), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 18/57 (31%), Positives = 31/57 (54%), Gaps = 1/57 (1%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAKVAH 91
            +AL  F AGE+  LS + G+ + +I+E D +WWT +   +  +   PS Y  ++  
Sbjct: 121 VLALYDFTAGEEGELSFKKGDRIEVINETDPNWWTGKLVATESQGLFPSTYTKEITE 177


>UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE
          Length = 321

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 36/105 (34%), Positives = 52/105 (49%), Gaps = 13/105 (12%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W    L+R  AEELLL  G P GAFLIR S + + CY+ SV ++      ++RH  I+
Sbjct: 217 ESWFVGDLARGPAEELLL--GKPNGAFLIRNS-SSKDCYACSVVVNS-----QVRHCVIR 268

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELAD-----GICCPLREPC 190
             + G+ ++ P     SL  LV HYS+ +       +   L  P 
Sbjct: 269 HTERGYGFVEPFDLHKSLKDLVLHYSQTSLAQHNQALDVRLAYPV 313



 Score = 67.8 bits (164), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 14/105 (13%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRE-SQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
            W +  +SRE+  E+L   G P GAFL+R+ S   +G Y+L+VR +      RI H    
Sbjct: 31  EWYWADISREEVNEIL--HGMPDGAFLVRDASCKVQGEYTLTVRNNGTNKLIRILH---- 84

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELAD-----GICCPLREPC 190
               G    S  LTF S+  L+  Y   +       +   L  P 
Sbjct: 85  --QEGKFGFSEPLTFSSVPELISFYRNRSLVHYNTSLDVTLAYPV 127


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 25/98 (25%), Positives = 53/98 (54%), Gaps = 5/98 (5%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            + +  ++RE++E  L   G+  G +L+R+S++  G Y+LS+         +  HY I+R
Sbjct: 9   PYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSY-----GRQFYHYTIER 63

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
             N    I+   +  +   ++ ++S+ +DG+ C L++P
Sbjct: 64  ELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKP 101



 Score = 90.1 bits (222), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 42/189 (22%), Positives = 63/189 (33%), Gaps = 33/189 (17%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
            A     W +  + RE +E  LL      G   I     R+               +++ 
Sbjct: 156 TAHEKMPWFHGKIDREDSELRLLNTSRVNGQ--ISNQTKRKQWQKRVPNALCLLHNNQVM 213

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HYRI +   G L I     F +L  LVEHYS   DG+   L E C           + P 
Sbjct: 214 HYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSEGSAENPY 273

Query: 206 PVT-----------------VPTSSLNWK------------KLDRSLLFLE--APASGEA 234
            +T                 +P  +  ++            K++RS L LE     SG  
Sbjct: 274 KITSNGKDNYSKQGNFLDSAMPMDTQVYESPYADPDELRSTKVNRSDLTLEDGELGSGNF 333

Query: 235 SLLSEGLRE 243
             +  G+ +
Sbjct: 334 GTVLRGVYQ 342


>UniRef50_Q9VHC3 Blistery n=8 Tax=Sophophora RepID=Q9VHC3_DROME
          Length = 720

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 40/132 (30%), Positives = 55/132 (41%), Gaps = 16/132 (12%)

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR--PASWD 142
           +    +  W    L+RE A  LL       G FL+R+S T +  Y L VR+S+  P S +
Sbjct: 450 FARSSSQFWYKPNLTREDAIALL--ASAQPGTFLVRDSTTYKDSYGLVVRVSQPPPGSQE 507

Query: 143 RIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPG 200
            +RH+ I+    G           F SL ALV  +S     + C LR P           
Sbjct: 508 LVRHFLIEPTKGGVHLKGCDDEPVFTSLSALVFEHSISQLALPCLLRLP----------D 557

Query: 201 KDTPPPVTVPTS 212
           +D  PPV   T 
Sbjct: 558 RDIVPPVRATTP 569


>UniRef50_B3S5N2 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S5N2_TRIAD
          Length = 322

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 31/118 (26%), Positives = 47/118 (39%), Gaps = 10/118 (8%)

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R+ AEE L       G FLIR S  +   Y+LS++     S   I HY I    
Sbjct: 13  YHGNIGRKNAEEELRKSIYEVGTFLIRSSTDKPN-YALSLKSPLKQS---IAHYLILWHG 68

Query: 154 ---NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
                +  I     FP++  L+  Y+   +G+ C L    +     P+P    PP   
Sbjct: 69  PIYQPFYSIEGGPLFPNISQLISFYTRSNEGLPCTLGFSVI---SNPMPRLQQPPAYP 123


>UniRef50_C3ZG97 Putative uncharacterized protein n=3 Tax=Chordata RepID=C3ZG97_BRAFL
          Length = 1558

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 31/95 (32%), Positives = 49/95 (51%), Gaps = 5/95 (5%)

Query: 85   YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES----QTRRGCYSLSVRLSRPAS 140
            ++  + + W    L R   +  LL   NP G FL+R      +T    Y++SV  S+  +
Sbjct: 1253 HLTILDYRWFVGPLDRRDTDNRLLCDDNPVGTFLVRSREDIGETGSHLYTISVLRSKTGN 1312

Query: 141  WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
             DR+ H+ +QR   G L+++  + F SL  LVEHY
Sbjct: 1313 -DRVSHFNVQRSTEGKLFVAADMEFDSLTELVEHY 1346


>UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2B n=7
           Tax=Clupeocephala RepID=SHP2B_DANRE
          Length = 1226

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 33/116 (28%), Positives = 50/116 (43%), Gaps = 11/116 (9%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +SR +AEELL   G   G+FL+R+S++  G Y+L +   R      +  YRI  
Sbjct: 5   PWYHRDISRVRAEELLAHAG-IDGSFLVRDSESVPGAYALCLLFQR-----HVHTYRILP 58

Query: 152 LDNGWLYISPR-----LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
             +G L +          F +L  LV  Y     G+  PL  P + +        D
Sbjct: 59  DADGLLAVQATQGVQVNCFRTLGDLVLGYQNPNKGLVAPLLYPVMRESEANDESSD 114


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 40/161 (24%), Positives = 63/161 (39%), Gaps = 28/161 (17%)

Query: 58  LTIISEDGDWWT---------VQSEVSGREYHMPSVYVAKVAHGWLYEGL--SREKAEEL 106
             +++ED  ++T              +  E    +     +   W +  L   R  AE+L
Sbjct: 502 YFVLTEDKLYFTDQQEKDEDEADKTETNTETLPST--EQHLKEKWFHGKLAGGRVAAEKL 559

Query: 107 LLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW---LYISPRL 163
           L    +  GAFL+RES T  G YSLS          +  H RI     G     Y+  + 
Sbjct: 560 LTDYKDVNGAFLVRESTTFTGDYSLSF-----VRDGKYNHCRIHTKSEGGKTRFYLIDQT 614

Query: 164 TFPSLHALVEHYSELADGICCPLREPCVLQKLG-PLPGKDT 203
            F S++ L+ HY          L+ P   Q L  P+P +++
Sbjct: 615 LFDSIYELIMHYKSNP------LKSPTFEQVLAEPVPQQNS 649



 Score = 88.2 bits (217), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 32/92 (34%), Positives = 48/92 (52%), Gaps = 11/92 (11%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQ--TRRGC--YSLSVRLSRPASWDRIRHY 147
            W +E LSR +AEE+L       GAFLIR S+  T+ G   Y++S R     +  +++H 
Sbjct: 654 AWFHENLSRSEAEEMLKKVRM-DGAFLIRPSEQNTKAGQKNYAISFR-----AEGKVKHC 707

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RI+  ++G  Y      F SL  LV++Y    
Sbjct: 708 RIEVDESGQ-YCIGSAIFDSLTELVQYYEANP 738



 Score = 42.4 bits (98), Expect = 0.015,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 22/57 (38%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV 89
            +T  AL  + A     LS      +T + + G  W      +  +   P+ +V +V
Sbjct: 781 PITCKALFDYTAVRPDELSFCKDAVITNVEKHGGGWWKGDCGNKNQKWFPANHVEEV 837


>UniRef50_A9V545 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V545_MONBE
          Length = 1565

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 35/145 (24%), Positives = 68/145 (46%), Gaps = 19/145 (13%)

Query: 57   PLTIISEDGDWWTVQSEVSGREYHMPS----------VYVAKVAHGWL-YEGLSREKAEE 105
             + ++ E+  +   ++E   RE H+ +          +Y+ K    W+ +   +R++A  
Sbjct: 956  VVIMVDEEMFYLVSKNEQDQRECHVFTTEGHDSFELVMYLQKTFQRWVEHTREARDRAMA 1015

Query: 106  LL--LLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWL-YISPR 162
             L  L    P GAF++R S ++ GC++LSV+ +     D++ HY ++RL +G   +    
Sbjct: 1016 KLTNLDHPVPNGAFVLRPSTSQPGCFALSVKFN-----DQVTHYLVERLTDGKFSFKDSD 1070

Query: 163  LTFPSLHALVEHYSELADGICCPLR 187
              F +L  L+ HY      +   L 
Sbjct: 1071 RAFLTLRDLIVHYCIFPTELPFRLT 1095



 Score = 79.7 bits (195), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 33/147 (22%), Positives = 53/147 (36%), Gaps = 19/147 (12%)

Query: 91   HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
              W +  +SR +AE  L     P G FL+R S T +  ++LS           I H  I 
Sbjct: 1126 QPWFFGDISRAEAEAQLSKHSRP-GLFLVRTSSTGKDNFALSFLDDE----CVITHVLIT 1180

Query: 151  RLDNGWLYISPRLTFPSLHALVEHYSE-LADGICCPLREPCVLQKLGPLPGKDTPPPVTV 209
             +D+    +  +    +L  LV+  S    D + CPL  PC             P P  V
Sbjct: 1181 FVDDLGFCLDGKPCADTLFDLVKICSTPEQDWLPCPLLMPC-------------PSPALV 1227

Query: 210  PTSSLNWKKLDRSLLFLEAPASGEASL 236
               ++   ++    +  E+        
Sbjct: 1228 HAPAVETLRVASDSMGRESALQSSDGD 1254


>UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY34_ACYPI
          Length = 214

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 19/174 (10%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYV 86
             P     + VA+  F +G   R+     E L I   +          SGR        V
Sbjct: 36  PLPNESVRSHVAM-DF-SGNVGRIVEDPKEALAIAQAETGSVRRSWRSSGRTTPGLQAAV 93

Query: 87  AKV------AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
            K+      +  W ++ +SR++A  +L   GN  G FLIRES+++ G Y LS +      
Sbjct: 94  TKLENDIHLSQPWYHKNMSRDQAANVLHALGNKDGVFLIRESKSKCGSYVLSFKC----- 148

Query: 141 WDRIRHYRI-----QRLDNGWLYISPR-LTFPSLHALVEHYSELADGICCPLRE 188
             +I H  I        D     +    + F  L  LVE Y   A  +   L  
Sbjct: 149 GGKIIHTPIVTQMDPLNDQVCFTLDNGVIKFYDLLQLVEFYQLNAGSLPTRLMH 202


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 32/92 (34%), Positives = 55/92 (59%), Gaps = 8/92 (8%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
           ++A  W +  ++R+ AE LL+   N  GAFL+R S++  G YSLSV+ +     + ++H+
Sbjct: 9   EIAMAWFFPTITRKNAELLLMQERN--GAFLVRRSESSEGLYSLSVKYN-----ESVQHF 61

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RI +   G  ++   + FPSL ALV++Y   +
Sbjct: 62  RILQDTAGKFHLWI-VKFPSLDALVDYYRTTS 92



 Score = 55.8 bits (133), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 22/92 (23%), Positives = 37/92 (40%), Gaps = 4/92 (4%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQP-ERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           SL +       +  +        S++   R+     AL  F   E+  L  R G+ +T+I
Sbjct: 80  SLDALVDYYRTTSVTRENQVSTQSVEQWSRNPQRLQALYDFDPEEEGELCFRKGDIITLI 139

Query: 62  SE-DGDWWTVQSEVSGREYHMPSVYVAKVAHG 92
            +   DWW  +  V GR   +P+ YV +    
Sbjct: 140 DKPTKDWW--RGTVDGRTGMLPAPYVKEEEEP 169


>UniRef50_UPI000194DBC6 PREDICTED: similar to tensin 4 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DBC6
          Length = 731

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 12/146 (8%)

Query: 72  SEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
           S+   +       +V   +  W    +SR++A +LL       G FL+R+S + RG + L
Sbjct: 449 SDSPLKAGQPTMKFVMDTSKYWFKPSISRDRAIQLLR--DKEPGTFLVRDSTSFRGSFGL 506

Query: 132 SVRLSRPASW--------DRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHYSELADG 181
           ++++    S         D +RH+ I+    G      S  L F SL A V  +S     
Sbjct: 507 AMKVPGSPSGSQTGEESSDLVRHFLIESSTKGVHLXGASEELYFGSLSAFVYQHSITPLA 566

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPV 207
           + C L  P      G      TP P 
Sbjct: 567 LPCKLSIPTRDLADGEDSPDCTPEPA 592


>UniRef50_P62993-2 Isoform GRB3-3 of Growth factor receptor-bound protein 2 n=10
           Tax=Deuterostomia RepID=P62993-2
          Length = 176

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 23/146 (15%), Positives = 54/146 (36%), Gaps = 48/146 (32%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H +
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPF 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
                                                           + ++H+++ R  
Sbjct: 61  -----------------------------------------------GNDVQHFKVLRDG 73

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++   + F SL+ LV+++   +
Sbjct: 74  AGKYFLWV-VKFNSLNELVDYHRSTS 98



 Score = 55.5 bits (132), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 7/70 (10%)

Query: 21  DQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREY 79
           D E V  QP        AL  F   E   L  R G+ + ++ + D +WW  +    G+  
Sbjct: 109 DIEQVPQQPTY----VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTG 162

Query: 80  HMPSVYVAKV 89
             P  YV  V
Sbjct: 163 MFPRNYVTPV 172


>UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RP74_TETNG
          Length = 968

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 13/133 (9%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           S   A     W +  +SR +AEELL   G   G++L+R+S++  G Y+L +   R     
Sbjct: 4   STLTAMATAVWYHRDISRVQAEELLARAGK-DGSYLVRDSESVPGAYALCLLFQR----- 57

Query: 143 RIRHYRIQRLDNGWLYISPR-----LTFPSLHALVEHYSELADGICCPLRE--PCVLQKL 195
            +  YRI    +G L +          F +L  LV  Y +   G+  PL    P  +   
Sbjct: 58  HVHTYRILPDADGLLAVQTTQGVQVNCFRTLEDLVFGYQQPHKGLVSPLLYGVPRDMDIG 117

Query: 196 GPLPGKDTPPPVT 208
                 + PPPV+
Sbjct: 118 DESSDDEKPPPVS 130


>UniRef50_B7P7A9 Growth factor receptor-bound protein, putative (Fragment) n=1
           Tax=Ixodes scapularis RepID=B7P7A9_IXOSC
          Length = 358

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 36/121 (29%), Positives = 51/121 (42%), Gaps = 14/121 (11%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W Y G+SRE+A +LLL  G   G FL+R+S ++ G + LS           + H +I
Sbjct: 239 TQPWFYSGMSREEATQLLLRHGTVDGVFLVRQSLSKPGTFVLSYAFR-----GTVHHVQI 293

Query: 150 QRLDN----GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
             ++      +   S R  F  L  LVE Y      +   L    V Q     P + T P
Sbjct: 294 ISVEEKDQLCYSLDSGRTKFYDLLQLVEFYQLNLSYLPTKLTHFLVHQ-----PRRRTTP 348

Query: 206 P 206
           P
Sbjct: 349 P 349


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 28/108 (25%), Positives = 46/108 (42%), Gaps = 12/108 (11%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           +  W +  +SR++AE LL       G+FL+R S    G +SLS         +R++H  I
Sbjct: 319 SEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRK-----NRVQHCHI 373

Query: 150 QRLDNG----WLYISPRLTFPSLHALVEHYSELA---DGICCPLREPC 190
           +           ++     F +L++L+ HY       D     L EP 
Sbjct: 374 KSRPTNDGTAKYFLVGPKGFDNLYSLINHYQTNPLKSDKFELMLTEPV 421



 Score = 83.2 bits (204), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 13/120 (10%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQT--RRGCYSLSVRLSRPASWDRIRHYRI 149
            W +E L+R +AEE+L         FL+R+     +   Y++S R     +   I+H  I
Sbjct: 431 DWYHENLTRLQAEEMLRRMRKDS-YFLVRKRNDGDQNESYAISFR-----TGGTIKHCVI 484

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC---VLQKLGPLPGKDTPPP 206
           ++   G L++     F SL  L+ HY +        L+ PC   V+Q+ G  P      P
Sbjct: 485 KK--EGRLFMIGTAPFESLTELIAHYEKNPLYRKTKLKYPCNQDVVQEFGMNPDGTFNDP 542


>UniRef50_A4F2N7 Mt-tensin-b (Fragment) n=2 Tax=Molgula tectiformis RepID=A4F2N7_9ASCI
          Length = 1177

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 39/150 (26%), Positives = 66/150 (44%), Gaps = 16/150 (10%)

Query: 82   PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
            P ++V  V + W    ++RE+A ++L     P G+F++R+S+   G Y L++++ +  S 
Sbjct: 887  PPLFVHDVQNLWYKPDITREQALDMLRH--RPAGSFVVRDSRCFPGAYGLALKVDKLPSN 944

Query: 142  DR-----------IRHYRIQRLDNGWLYIS--PRLTFPSLHALVEHYSELADGICCPLRE 188
             R           +RH+ I+    G           F SL ALV  +S     + C L  
Sbjct: 945  VRPQAGADIQNELVRHFLIEPSSRGVKLKGCKNEPVFGSLPALVYQHSITPLALPCRLII 1004

Query: 189  PCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
            P  +    P PG    P   VP S+ +  +
Sbjct: 1005 P-KIDPATPPPGTLPRPGTEVPNSATDLLR 1033


>UniRef50_UPI000194BDF4 PREDICTED: hypothetical protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194BDF4
          Length = 1106

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 38/118 (32%), Positives = 55/118 (46%), Gaps = 24/118 (20%)

Query: 90  AHGWLYEGLS-----REKAEELLLL----PGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
              W +  L      R+ AE+LL       G   G FL+RES+T  G Y+LS   S    
Sbjct: 384 TEKWFHGKLGGGRDGRQIAEKLLHEYCTETGGKDGTFLVRESETFVGDYTLSFWRSS--- 440

Query: 141 WDRIRHYRIQ-RLDNG--WLYISPRLTFPSLHALVEHYSELADGICC-----PLREPC 190
             R++H RI  R + G    Y++  L F SL++L+ HY E+   + C      L +P 
Sbjct: 441 --RVQHCRIHSRQEAGATKFYLTDNLVFDSLYSLICHYREVP--LRCNEFEMRLTDPV 494



 Score = 54.7 bits (130), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 5/68 (7%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
           A  +  W +  L+R +AE +L+      GAFL+R+  +    Y++S R     +   +  
Sbjct: 499 AHESKEWYHASLTRLQAEHMLMRVPR-DGAFLVRKR-SEPNSYAISFR---KCTVKALYD 553

Query: 147 YRIQRLDN 154
           Y+ QR D 
Sbjct: 554 YKAQREDE 561



 Score = 45.4 bits (106), Expect = 0.002,   Method: Composition-based stats.
 Identities = 14/68 (20%), Positives = 24/68 (35%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHM 81
            EP S      K T  AL  + A  +  LS      +  + +    W        ++   
Sbjct: 534 SEPNSYAISFRKCTVKALYDYKAQREDELSFCKQAIIHNVDKQDGGWWRGDYGGKKQLWF 593

Query: 82  PSVYVAKV 89
           P+ YV ++
Sbjct: 594 PANYVEEI 601


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 35/173 (20%), Positives = 62/173 (35%), Gaps = 31/173 (17%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               W +  + R ++  LL       G FL+RES    G + LS +     +  ++RH++
Sbjct: 466 KEQTWFHGTIPRTESLRLLQQ----DGDFLLRESNNSLGDFVLSAK-----ADGQVRHFK 516

Query: 149 IQRLDNGWLYISPRLTFPSLHALV-EHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
           +Q  DNG         FP++  L+  HY +         REP   +    L         
Sbjct: 517 VQVTDNGMYRFEAD-QFPTVLNLISHHYQK---------REPVTKRTNCLLLN------- 559

Query: 208 TVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL--RESLSSYISLAEDPLDD 258
             P     W+              G    + + L  RE+    +   ++ +D+
Sbjct: 560 --PICKDKWQLSHDDFTIDCKIGQGNFGEVYKALFIRENYYVAVKTCKETVDN 610


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 90.1 bits (222), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 13/104 (12%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  L+  +AEELL       G+FL+R S+++ G +++SV+ +      ++ H +IQ  
Sbjct: 5   WFHSSLNGSQAEELL--TPLADGSFLVRPSESKHGDFTISVKCN-----GKVTHIKIQND 57

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELAD------GICCPLREPC 190
            + +L I     FP+L +LV HY    +      G+   L  P 
Sbjct: 58  GDSFLLIGSPDPFPTLESLVSHYRNTPNSIKEKSGVFIELLYPV 101



 Score = 85.9 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 30/114 (26%), Positives = 48/114 (42%), Gaps = 13/114 (11%)

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           P          W +  +  ++AE +LL  G   G++L+RESQ++ G + L V+ +     
Sbjct: 100 PVRSTDPTTERWYHGSIGAKEAERMLLSKGRL-GSYLVRESQSQPGQFVLVVKCANGVQQ 158

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY------SELADGICCPLREP 189
                  I    N    I    +F SL  L+E+Y       ++ D     LREP
Sbjct: 159 ------VIISCRNKKYEIKSGPSFASLQELIEYYVMNPKLHDVKDQSPIKLREP 206


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score = 89.7 bits (221), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 12/109 (11%)

Query: 71  QSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
            ++ SG+    P          W Y  ++R + + +L   G+  G FLIR+S+T  G YS
Sbjct: 430 AAQSSGQPIERP----NLAGKSWYYGAITRSQCDTVLNGHGH-DGDFLIRDSETNMGDYS 484

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           +S++     +  R +H+R+    N  +Y   +  F SL  LV+HY    
Sbjct: 485 VSLK-----APGRNKHFRVHVEQN--MYCIGQRKFHSLDQLVDHYQRAP 526



 Score = 64.3 bits (155), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 16/78 (20%), Positives = 28/78 (35%), Gaps = 1/78 (1%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSG 76
           +          + +      VA   + A     L LR  E   ++ +   WW VQ+  + 
Sbjct: 136 TQSMAGNMKHGKSQDDVCYVVAKYDYAAQGAQELDLRKNERYLLLDDSKHWWRVQNSRN- 194

Query: 77  REYHMPSVYVAKVAHGWL 94
           +  ++PS YV K      
Sbjct: 195 QSGYVPSNYVKKEKPSLF 212



 Score = 62.8 bits (151), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 4/64 (6%)

Query: 29  PERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVY 85
            E      VAL SF +     LS   G+ L I+     D DW+  ++   G+   +P  Y
Sbjct: 322 AENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQ-GQVGLVPRNY 380

Query: 86  VAKV 89
           + ++
Sbjct: 381 LQEL 384



 Score = 51.2 bits (121), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 15/70 (21%), Positives = 25/70 (35%), Gaps = 1/70 (1%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHM 81
              +   P     TAV   ++ A +   LSL  G  + I+ +  D W  + +        
Sbjct: 243 SRRLPPDPAEAIGTAVVKYNYQAQQPDELSLTKGTRILILEKSNDGWW-RGQSGNSVGWF 301

Query: 82  PSVYVAKVAH 91
           PS Y  +   
Sbjct: 302 PSNYTTEDCD 311


>UniRef50_C3Y8I0 Putative uncharacterized protein (Fragment) n=1 Tax=Branchiostoma
           floridae RepID=C3Y8I0_BRAFL
          Length = 101

 Score = 89.7 bits (221), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 13/96 (13%)

Query: 90  AHGWLYEGL--SREKAEELLLL----PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
           +  W Y  +   R++A++LL        +P G FL+R+S T  G +SL+       +  +
Sbjct: 5   SEPWFYGKVAGGRKQADKLLREYVKTKSSPDGCFLVRDSDTFVGDFSLTFW-----AEGK 59

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           I+H RI++  +G L++     F SL  LV +Y E A
Sbjct: 60  IKHCRIKQ--DGRLFVIGTAQFESLIKLVNYYKENA 93


>UniRef50_A9V5H9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5H9_MONBE
          Length = 318

 Score = 89.7 bits (221), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 6/90 (6%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V      W +  + R+KAE +L   G   G FLIR + ++  CY+L++         RI 
Sbjct: 217 VNPNNPPWFHMTVDRQKAESMLRKAGLQDGMFLIRPA-SKPRCYALTM-----CRHGRIL 270

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
           H  I+ + + + Y+ P  TF SL  LVEHY
Sbjct: 271 HNTIEAVGHRYRYVGPDRTFDSLADLVEHY 300


>UniRef50_UPI000069FBD6 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=2 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD6
          Length = 1664

 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 16/129 (12%)

Query: 75   SGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
            + ++  +   +V   +  W    +SRE+A  +L   G   G+FLIR+S + RG Y L+++
Sbjct: 1375 TQQDVPVTGNFVQDSSKFWYKPTISREQAIAILR--GAEPGSFLIRDSNSFRGAYGLALK 1432

Query: 135  ------------LSRPASWDRIRHYRIQRLDNGWLYISP--RLTFPSLHALVEHYSELAD 180
                            ++   +RH+ I+    G           F SL ALV  +S    
Sbjct: 1433 VASPPPNVAAQPYKGDSTEQLVRHFLIETGPKGVKIKGSPIEPHFGSLSALVSQHSVTPL 1492

Query: 181  GICCPLREP 189
             + C L+ P
Sbjct: 1493 SLPCRLQIP 1501


>UniRef50_Q95ZL4 Temporarily assigned gene name protein 163, isoform a n=5
           Tax=Caenorhabditis RepID=Q95ZL4_CAEEL
          Length = 1112

 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 30/114 (26%), Positives = 51/114 (44%), Gaps = 11/114 (9%)

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW--- 141
           +V   +  W    +SRE+A  +L     P G F++R+S +  G + L++++S P      
Sbjct: 833 FVKDTSKYWYKPTISREQAINMLR--DKPPGTFVVRDSNSFPGAFGLALKVSTPPPGVNP 890

Query: 142 ----DRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHYSELADGICCPLREP 189
               + +RH+ I+    G      +    F SL ALV  +S  A  +   L  P
Sbjct: 891 GDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALPTKLVLP 944


>UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SVT4_TETNG
          Length = 1377

 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 41/145 (28%), Positives = 59/145 (40%), Gaps = 23/145 (15%)

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS-----REKAEELLLL---PGNP 113
            E   + T   E         +      A  W +  L      R+ AE+LL      G  
Sbjct: 539 EETSHYQTADEEEDDEVKEECNNNEQHCAERWFHGKLGGGRDGRQVAEKLLQEYCEGGAK 598

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTFPSLHA 170
            G FL+RES+T  G Y+LS   S      R++H RI  R ++G    Y++  L F SL+ 
Sbjct: 599 DGTFLVRESETFVGDYTLSFWRS-----GRVQHCRIHSRQESGSTRFYLTDNLVFDSLYR 653

Query: 171 LVEHYSELADGICC-----PLREPC 190
           L+ HY +    + C      L  P 
Sbjct: 654 LICHYRDTP--LRCNEFEMRLGNPV 676



 Score = 83.6 bits (205), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 8/121 (6%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  L+R +AE +L+      GAFL+R+  +    Y++S R     +  +I+H RIQ+
Sbjct: 686 EWYHSSLTRVQAEHMLMRVPR-DGAFLVRKR-SEHNSYAISFR-----AEGKIKHCRIQQ 738

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
            +     +     F SL  LV +Y +        LR P     L  +    +  P     
Sbjct: 739 -EGRLFMLGSSAEFESLMDLVSYYEKHPLYRKMKLRYPINEDTLDKMGTTVSRAPPERRR 797

Query: 212 S 212
           S
Sbjct: 798 S 798



 Score = 41.6 bits (96), Expect = 0.024,   Method: Composition-based stats.
 Identities = 18/88 (20%), Positives = 35/88 (39%), Gaps = 10/88 (11%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGE-PLTIISEDGDWWTVQSEVSG-REYHMPSVYVAKVA 90
           + T  AL  + A  +  L        L +  ++G WW  + +  G ++   P+ YV ++ 
Sbjct: 836 RCTVKALYDYRAQREDELCFSKQALILNVDKQEGGWW--RGDYGGKKQLWFPANYVEELP 893

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFL 118
                      + +E +    +P G FL
Sbjct: 894 SS------PLRELDEAVSSKNSPLGTFL 915


>UniRef50_UPI000069FBD7 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=1 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD7
          Length = 1410

 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 34/133 (25%), Positives = 59/133 (44%), Gaps = 17/133 (12%)

Query: 72   SEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
            S  + ++  +   +V   +  W    +SRE+A  +L   G   G+FLIR+S + RG Y L
Sbjct: 1117 STDTQQDVPVTGNFVQDSSKFWYKPTISREQAIAILR--GAEPGSFLIRDSNSFRGAYGL 1174

Query: 132  SVRLSRP-------------ASWDRIRHYRIQRLDNGWLYISP--RLTFPSLHALVEHYS 176
            +++++ P             ++   +RH+ I+    G           F SL ALV  +S
Sbjct: 1175 ALKVASPPPNVAAQPYKAGDSTEQLVRHFLIETGPKGVKIKGSPIEPHFGSLSALVSQHS 1234

Query: 177  ELADGICCPLREP 189
                 + C L+ P
Sbjct: 1235 VTPLSLPCRLQIP 1247


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 30/156 (19%), Positives = 56/156 (35%), Gaps = 31/156 (19%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG---CYSLSVRLSRPASWDRIRH 146
              W +  L RE  + +L       G FLIR ++ ++G    Y LS   +       ++H
Sbjct: 8   TEPWYHGLLPREDIKAMLRKT----GDFLIRSTEPKQGEARQYVLSAMQNEELEDAGVKH 63

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI--CCPLREPCVLQKLGPLPGKDTP 204
           Y ++   N  +++     F ++ +LV +Y    D I     L+ P V Q           
Sbjct: 64  YVMRVNANNQIFL-ETKGFETITSLVNYYMTTKDPIKKMTVLKTPIVKQ----------- 111

Query: 205 PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
                     +W+     +   +    G    + +G
Sbjct: 112 ----------DWEIEHSQVELTKKLGEGAFGEVWKG 137


>UniRef50_Q8MQW8 Protein sprint n=6 Tax=Drosophila RepID=SPRI_DROME
          Length = 1790

 Score = 89.3 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 37/109 (33%), Positives = 54/109 (49%), Gaps = 5/109 (4%)

Query: 89  VAHG-WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
           V H  W   G+ R  A  LL   G   G F++R S ++    ++SVRL +  +   I HY
Sbjct: 469 VTHPMWFLPGIQRSGAVHLL--QGKEEGTFIVRGS-SQPNTMAVSVRLPQD-TGPYIEHY 524

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
            IQ  DN     S R TF S+ +L+ HY++  D +   L  P VL++  
Sbjct: 525 LIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREAN 573


>UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS
          Length = 727

 Score = 89.0 bits (219), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR--IRHYRIQ 150
           W    LSRE A  LL       G FL+R+S T +  Y L VR+++P +  +  +RH+ I+
Sbjct: 466 WYKANLSREDAIALL--ASAQPGTFLVRDSTTYKNAYGLVVRVAQPPAGSQELVRHFLIE 523

Query: 151 RLDNGWLY--ISPRLTFPSLHALVEHYSELADGICCPLREP 189
               G           F SL ALV  +S     + C LR P
Sbjct: 524 PTREGVRLKGCDNEPVFTSLSALVFEHSINRLALPCLLRLP 564


>UniRef50_A9V1L3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V1L3_MONBE
          Length = 970

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 7/120 (5%)

Query: 98  LSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWL 157
           L RE++E +L       G FLIRES+TR G Y L++     A    I H+ I+R     L
Sbjct: 850 LGRERSELMLNHGKVADGMFLIRESKTRAGTYVLTM-----AHAGTIHHFPIERTPTNRL 904

Query: 158 YISPRLTFPSLHALVEHYS-ELADGICCPLREPCVLQK-LGPLPGKDTPPPVTVPTSSLN 215
             +    F     LV  +  +  +G+ C L + C     +  +P   T  P        +
Sbjct: 905 KTNNGHQFADWEELVHFFKTKDREGLPCRLTQACSSYDHMLTMPATTTQAPNDEQFGFGD 964


>UniRef50_UPI000069FBD8 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=1 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD8
          Length = 1393

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 16/123 (13%)

Query: 81   MPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR------ 134
            +   +V   +  W    +SRE+A  +L   G   G+FLIR+S + RG Y L+++      
Sbjct: 1111 VTGNFVQDSSKFWYKPTISREQAIAILR--GAEPGSFLIRDSNSFRGAYGLALKVASPPP 1168

Query: 135  ------LSRPASWDRIRHYRIQRLDNGWLYISP--RLTFPSLHALVEHYSELADGICCPL 186
                      ++   +RH+ I+    G           F SL ALV  +S     + C L
Sbjct: 1169 NVAAQPYKGDSTEQLVRHFLIETGPKGVKIKGSPIEPHFGSLSALVSQHSVTPLSLPCRL 1228

Query: 187  REP 189
            + P
Sbjct: 1229 QIP 1231


>UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 n=40
           Tax=Euteleostomi RepID=SHIP1_HUMAN
          Length = 1189

 Score = 88.6 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 47/176 (26%), Positives = 71/176 (40%), Gaps = 15/176 (8%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R KAEELL   G   G+FL+R S++    Y+L V        + +  YRI   
Sbjct: 5   WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYR-----NCVYTYRILPN 58

Query: 153 DNGWLYISPR-----LTFPSLHALVEHYSELADGICCPLREPCVLQK--LGPLPGKDTPP 205
           ++    +          F  L  L+E Y +   G+   L+ P  L++   G  P +DT  
Sbjct: 59  EDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVE 118

Query: 206 PVTVP--TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
            V  P      N      S    E P S E    +E  R SLS  +      +D +
Sbjct: 119 SVVSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTS 174


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 49/90 (54%), Gaps = 7/90 (7%)

Query: 91  HGWLYEGLSREKAEELLLLPG-NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
           + W +  L+R +A +L+L  G +  G FL+R+S+TR+G + L+          + +H R+
Sbjct: 437 YPWFHGTLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTFNFQ-----GKAKHLRM 491

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELA 179
              D G   +   L FPS+  ++EH+ + A
Sbjct: 492 TLNDLGQCRVQ-HLWFPSITEMLEHFRQHA 520


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   256   5e-67
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   249   6e-65
UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2...   248   2e-64
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   248   2e-64
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   245   1e-63
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   244   2e-63
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   243   6e-63
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   243   6e-63
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   240   5e-62
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   238   2e-61
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   234   2e-60
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   230   5e-59
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   228   1e-58
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          226   5e-58
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   225   9e-58
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   225   1e-57
UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 ...   224   1e-57
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   223   4e-57
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   223   4e-57
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   223   4e-57
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   223   6e-57
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          222   8e-57
UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A...   222   9e-57
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   222   9e-57
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   221   1e-56
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   220   3e-56
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   220   4e-56
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   219   5e-56
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   218   1e-55
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   218   1e-55
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   216   5e-55
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   213   3e-54
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   213   3e-54
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   213   7e-54
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   211   2e-53
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   211   2e-53
UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californic...   210   3e-53
UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_...   209   6e-53
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   208   1e-52
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   206   6e-52
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...   206   8e-52
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   205   1e-51
UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...   204   3e-51
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...   204   3e-51
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...   200   3e-50
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   200   4e-50
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   200   4e-50
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   199   5e-50
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   199   8e-50
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   196   4e-49
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   196   5e-49
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   196   7e-49
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   195   2e-48
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   193   4e-48
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   193   7e-48
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   191   1e-47
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     190   3e-47
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   189   5e-47
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   189   7e-47
UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   189   9e-47
UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homini...   187   3e-46
UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q...   186   6e-46
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   186   6e-46
UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun se...   185   1e-45
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   185   2e-45
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   183   4e-45
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   183   7e-45
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   181   2e-44
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   181   2e-44
UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun se...   179   6e-44
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   178   2e-43
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...   176   9e-43
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...   176   9e-43
UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Tak...   175   1e-42
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   174   3e-42
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   173   4e-42
UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (...   169   7e-41
UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative ...   169   1e-40
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   163   6e-39
UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   162   1e-38
UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein ...   161   3e-38
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   159   9e-38
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   159   1e-37
UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes...   158   2e-37
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   157   2e-37
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   157   2e-37
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...   156   5e-37
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   156   6e-37
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   153   6e-36
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   150   4e-35
UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tet...   149   9e-35
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   149   9e-35
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   147   4e-34
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   147   5e-34
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   146   7e-34
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...   143   6e-33
UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorh...   142   8e-33
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...   142   1e-32
UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia t...   141   2e-32
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...   141   3e-32
UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n...   139   7e-32
UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n...   137   2e-31
UniRef50_B7Z4J2 cDNA FLJ50391, highly similar to SRC-like-adapte...   137   3e-31
UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE      137   4e-31
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...   137   4e-31
UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo sal...   137   4e-31
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   136   6e-31
UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE    136   6e-31
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   134   4e-30
UniRef50_Q4T2Z8 Chromosome 18 SCAF10147, whole genome shotgun se...   133   4e-30
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME       133   5e-30
UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2)...   133   6e-30
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...   133   7e-30
UniRef50_UPI00016E6CB5 UPI00016E6CB5 related cluster n=4 Tax=Tak...   131   2e-29
UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicu...   131   3e-29
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   130   5e-29
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI         130   6e-29
UniRef50_Q4SM94 Chromosome 3 SCAF14553, whole genome shotgun seq...   129   1e-28
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   129   1e-28
UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n...   128   2e-28
UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Dan...   127   3e-28
UniRef50_UPI00017B38C7 UPI00017B38C7 related cluster n=1 Tax=Tet...   126   6e-28
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   125   1e-27
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   125   1e-27
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   125   2e-27
UniRef50_B4DP99 cDNA FLJ51496, highly similar to Tyrosine-protei...   124   2e-27
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   124   2e-27
UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound p...   123   5e-27
UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=...   123   5e-27
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...   123   5e-27
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...   122   1e-26
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...   122   1e-26
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   122   1e-26
UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   122   1e-26
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   121   2e-26
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...   121   2e-26
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   120   3e-26
UniRef50_Q5BYR6 SJCHGC04559 protein (Fragment) n=1 Tax=Schistoso...   120   5e-26
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...   120   6e-26
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   119   9e-26
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...   119   1e-25
UniRef50_UPI00016E9C47 UPI00016E9C47 related cluster n=1 Tax=Tak...   119   1e-25
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   119   1e-25
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...   119   1e-25
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   118   2e-25
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   118   2e-25
UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax...   117   3e-25
UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=...   117   3e-25
UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein act...   117   4e-25
UniRef50_Q9UKW4 Guanine nucleotide exchange factor VAV3 n=112 Ta...   117   4e-25
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   117   5e-25
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   116   8e-25
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   116   8e-25
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   115   9e-25
UniRef50_P78453 Tyrosine kinase (Fragment) n=11 Tax=Euteleostomi...   115   1e-24
UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Tak...   115   1e-24
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...   115   1e-24
UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=...   115   2e-24
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...   115   2e-24
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   114   2e-24
UniRef50_B1AH86 GRB2-related adaptor protein 2 (Fragment) n=3 Ta...   114   3e-24
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...   114   3e-24
UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleos...   113   5e-24
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...   113   5e-24
UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine ki...   112   8e-24
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...   112   8e-24
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...   111   2e-23
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN         111   3e-23
UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS         110   3e-23
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...   110   4e-23
UniRef50_Q70W05 Src protein (Fragment) n=1 Tax=Ciona intestinali...   110   5e-23
UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi s...   110   5e-23
UniRef50_Q4JSB7 Tensin n=4 Tax=Culicidae RepID=Q4JSB7_ANOGA           109   7e-23
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...   109   7e-23
UniRef50_UPI0000EB251F Tyrosine-protein kinase Tec (EC 2.7.10.2)...   109   7e-23
UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene ...   109   1e-22
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...   109   1e-22
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   109   1e-22
UniRef50_Q5BXE5 SJCHGC04002 protein (Fragment) n=1 Tax=Schistoso...   108   2e-22
UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepI...   108   2e-22
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...   108   2e-22
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   107   3e-22
UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax...   107   3e-22
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   107   3e-22
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...   107   3e-22
UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos...   107   4e-22
UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorh...   107   4e-22
UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluvia...   107   5e-22
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...   107   5e-22
UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostom...   107   5e-22
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    107   5e-22
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   107   6e-22
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...   106   6e-22
UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa ...   106   7e-22
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   106   7e-22
UniRef50_UPI000186F028 conserved hypothetical protein n=1 Tax=Pe...   106   8e-22
UniRef50_C3YUH5 Putative uncharacterized protein n=1 Tax=Branchi...   105   1e-21
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...   105   1e-21
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...   105   1e-21
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...   105   1e-21
UniRef50_UPI0000D555ED PREDICTED: similar to CG33993 CG33993-PA ...   105   2e-21
UniRef50_UPI000155BA92 PREDICTED: similar to Fyn-related kinase,...   105   2e-21
UniRef50_UPI00015B5EF2 PREDICTED: similar to ENSANGP00000021630 ...   105   2e-21
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   104   2e-21
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...   104   2e-21
UniRef50_A4F2N7 Mt-tensin-b (Fragment) n=2 Tax=Molgula tectiform...   104   3e-21
UniRef50_A7T8K3 Predicted protein n=1 Tax=Nematostella vectensis...   104   3e-21
UniRef50_C4Q5Y9 Tensin-related n=1 Tax=Schistosoma mansoni RepID...   104   3e-21
UniRef50_Q63HR2 Tensin-like C1 domain-containing phosphatase n=2...   104   4e-21
UniRef50_Q7Q480 AGAP008273-PA (Fragment) n=3 Tax=Culicidae RepID...   104   4e-21
UniRef50_Q380D8 AGAP001259-PA (Fragment) n=3 Tax=Culicidae RepID...   104   4e-21
UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n...   103   5e-21
UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=...   103   5e-21
UniRef50_Q9VRS2 CG32406 n=13 Tax=Drosophila RepID=Q9VRS2_DROME        103   6e-21
UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY3...   103   7e-21
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS         102   8e-21
UniRef50_A7RU23 Predicted protein n=1 Tax=Nematostella vectensis...   102   1e-20
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   102   1e-20
UniRef50_UPI000194DBC6 PREDICTED: similar to tensin 4 n=1 Tax=Ta...   102   1e-20
UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosph...   102   2e-20
UniRef50_A7URX1 AGAP006893-PA n=3 Tax=Culicidae RepID=A7URX1_ANOGA    102   2e-20
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...   101   2e-20
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...   101   2e-20
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...   101   3e-20
UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome ...   100   3e-20
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...   100   3e-20
UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n...   100   4e-20
UniRef50_P52735 Guanine nucleotide exchange factor VAV2 n=43 Tax...   100   4e-20
UniRef50_B7QKA0 Putative uncharacterized protein n=1 Tax=Ixodes ...   100   4e-20
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...   100   5e-20
UniRef50_UPI00006A0ADF Tensin-1. n=4 Tax=Xenopus (Silurana) trop...   100   5e-20
UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rer...   100   5e-20
UniRef50_A7S295 Predicted protein n=1 Tax=Nematostella vectensis...   100   5e-20
UniRef50_Q95ZL4 Temporarily assigned gene name protein 163, isof...   100   6e-20
UniRef50_Q6NR09 CG33993 n=13 Tax=Diptera RepID=Q6NR09_DROME           100   6e-20
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...    99   1e-19
UniRef50_Q18684 Protein T13H10.1, confirmed by transcript eviden...    99   1e-19
UniRef50_UPI0000ECCD76 tensin 3 n=1 Tax=Gallus gallus RepID=UPI0...    99   1e-19
UniRef50_UPI0001760C6E PREDICTED: similar to Tensin-like C1 doma...    99   1e-19
UniRef50_C4Q0E9 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...    99   2e-19
UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...    99   2e-19
UniRef50_Q4RVK7 Chromosome 15 SCAF14992, whole genome shotgun se...    99   2e-19
UniRef50_B4JFU1 GH19392 (Fragment) n=6 Tax=cellular organisms Re...    99   2e-19
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...    98   2e-19
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    98   2e-19
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...    98   2e-19
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...    98   3e-19
UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchi...    98   3e-19
UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Br...    98   3e-19

Sequences not found previously or not previously below threshold:

UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schisto...   104   3e-21

>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  256 bits (654), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 91/265 (34%), Positives = 131/265 (49%), Gaps = 26/265 (9%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHK--------VTAVALGSFPAGEQARLSLRLGEPLT 59
           G    P PS +G   E +   P+  +           VAL  + A     LS R GE L 
Sbjct: 32  GVPQIPMPSHAGQPPEQIRPVPQIPESETAGANAKIFVALYDYDARTDEDLSFRKGEHLE 91

Query: 60  IISE-DGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPG 114
           I+++  GDWW  +S+ +  E ++PS YVAK     A  W +  + R +AE+ LLLP N  
Sbjct: 92  ILNDTQGDWWLARSKKTRSEGYIPSNYVAKLKSIEAEPWYFRKIKRIEAEKKLLLPENEH 151

Query: 115 GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEH 174
           GAFLIR+S++R   YSLSVR       D ++HYRI++LD G  +I+ R TF +L  LVEH
Sbjct: 152 GAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEH 206

Query: 175 YSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEA 234
           YS+ +DG+C  L +PCV         +          +   W+    SL F+    SG+ 
Sbjct: 207 YSKDSDGLCVNLCKPCVQ-------IEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQF 259

Query: 235 SLLSEGLRESLS-SYISLAEDPLDD 258
             + EGL  + +   I   +    D
Sbjct: 260 GDVWEGLWNNTTPVAIKTLKSGTMD 284


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  249 bits (636), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 78/226 (34%), Positives = 108/226 (47%), Gaps = 14/226 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAK---- 88
              VAL  + A  +  LS   GE   I++  +GDWW  +S  +G   ++PS YVA     
Sbjct: 85  TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            A  W +  L R+ AE  LL  GNP G FLIRES+T +G YSLS+R       D ++HY+
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I++LDNG  YI+ R  F +L  LV+HYSE A G+CC L  PC                V 
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDV- 263

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAE 253
                  W+    SL  ++   +G+   +  G         I   +
Sbjct: 264 -------WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK 302


>UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2_HUMAN
          Length = 261

 Score =  248 bits (632), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 205/262 (78%), Positives = 221/262 (84%), Gaps = 4/262 (1%)

Query: 1   MGSLSSRGKTSSPSPSSSGPD-QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGSL SR K+      SS    Q PV+M+ ER K TAVALGSFPAG  A LSLRLGEPLT
Sbjct: 1   MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+SEDGDWWTV SEVSGREY++PSV+VAKV+HGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61  IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RESQTRRG YSLSVRLSRPASWDRIRHYRI  LDNGWLYISPRLTFPSL ALV+HYSELA
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA 180

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           D ICC L+EPCVLQ+ GPLPGKD P PVTV  + LNWK+LD SLLF EA A+GE SLLSE
Sbjct: 181 DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEA-ATGEESLLSE 239

Query: 240 GLRESLSSYISLAEDP--LDDA 259
           GLRESLS YISL ++   LDDA
Sbjct: 240 GLRESLSFYISLNDEAVSLDDA 261


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  248 bits (632), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 84/250 (33%), Positives = 123/250 (49%), Gaps = 18/250 (7%)

Query: 15  PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSE 73
           P+        V           VAL  + A     LS + GE L I+++  GDWW  +S+
Sbjct: 64  PTIPSAVPPEVETSAATGTKIFVALYDYDARTDEDLSFKKGEHLDILNDTQGDWWFARSK 123

Query: 74  VSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
            + +E ++PS YVAK     A  W +  + R +AE+ LLLP N  GAFL+R+S++RR  +
Sbjct: 124 STKQEGYIPSNYVAKLKSIEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDF 183

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           SLSVR       D ++HYRI++LD G  +I+ R TF +L  LV+HY   ADG+C  LR+P
Sbjct: 184 SLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVDHYGNEADGLCVNLRKP 238

Query: 190 CVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS-SY 248
           CV  +     G               W+    SL F+     G+   + EGL  + +   
Sbjct: 239 CVQVEKPMTSGLSHST-------RDQWEIERSSLKFVRKLGQGQFGEVWEGLWNNTTPVA 291

Query: 249 ISLAEDPLDD 258
           I   +    D
Sbjct: 292 IKTLKPGTMD 301


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  245 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 66/233 (28%), Positives = 111/233 (47%), Gaps = 18/233 (7%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSEVSGREYHMPSV 84
                      VA+ S+       L    G+ L II++D  +W+  +S  +G+  ++P  
Sbjct: 45  PPSSPLPDNLVVAIYSYNPKHDGDLGFEKGDKLKIINKDDSEWYLAESLTTGQRGYIPYN 104

Query: 85  YVAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           ++A        W ++ +SR +A   L+ PGN  G+FL+RES+T  G YSLS+R     + 
Sbjct: 105 FIAMSTMETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFDN-NG 163

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
           D ++HYRI+ +DNG  YI+ +++F SL  LV+HYS  +DG+C  L +PC  +       +
Sbjct: 164 DGVKHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGLCTKLVKPCQSKAPQKPWWQ 223

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAE 253
           D             W+    SL       +G+   +  G+  +     I   +
Sbjct: 224 D------------EWEIPRESLKLERKLGAGQFGEVWMGVYNNERRVAIKCLK 264


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 78/226 (34%), Positives = 108/226 (47%), Gaps = 17/226 (7%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAK---- 88
              VAL  + A     LS + GE   II+  +GDWW  +S  +G+  ++PS YVA     
Sbjct: 94  TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSI 153

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
            A  W +  + R+ AE LLL PGN  G FL+RES+T +G YSLS+R       D ++HY+
Sbjct: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I++LDNG  YI+ R  F +L  LV+HY+E ADG+C  L   C   K           P T
Sbjct: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVK-----------PQT 262

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAE 253
              +   W+    SL        G    +  G         I   +
Sbjct: 263 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK 308


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  243 bits (619), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 87/261 (33%), Positives = 129/261 (49%), Gaps = 21/261 (8%)

Query: 4   LSSRGKTSSPSPSS---SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           +S++ K + P P     +     P     +  K   VAL  + A     L +  GE L +
Sbjct: 28  VSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQV 87

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGA 116
           +   GDWW  +S V+GRE ++PS +VA+        W +    R++AE  LL P N  G+
Sbjct: 88  LKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGS 147

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FLIRES+T +G +SLSV+       + I+HY+I+ LD G  YISPR+TFPSL ALV+HYS
Sbjct: 148 FLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYS 206

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
           +  DG+C  L  PCV             P    P +   W+   +SL  +    SG+   
Sbjct: 207 KKGDGLCQRLTLPCVR------------PAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGE 254

Query: 237 LSEGLRESL-SSYISLAEDPL 256
           +  G  ++     I   ++  
Sbjct: 255 VWMGYYKNNMKVAIKTLKEGT 275


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  243 bits (619), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 79/257 (30%), Positives = 122/257 (47%), Gaps = 22/257 (8%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           S  S+   +    S + P      M         VAL  + A     LS + GE L II+
Sbjct: 31  SPFSQNTNNIMHVSHNQPPNINPPMLGGPGVTIFVALYDYEARISEDLSFKKGERLQIIN 90

Query: 63  E-DGDWWTVQSEVSGREYHMPSVYVAKVAHG----WLYEGLSREKAEELLLLPGNPGGAF 117
             DGDWW  +S ++  E ++PS YVA         W +  + R +AE+ L++ G P G F
Sbjct: 91  TADGDWWYARSLITNSEGYIPSTYVAPEKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTF 150

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           LIR+++T  G +SLSVR       D ++HYR+++LD G  +I+ R  F SL+ LV+HY++
Sbjct: 151 LIRKAETAVGNFSLSVRD-----GDSVKHYRVRKLDTGGYFITTRAPFNSLYELVQHYTK 205

Query: 178 LADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLL 237
            ADG+ C L  PC   K           PVT   +   W+    SL       +G+   +
Sbjct: 206 DADGLVCALTLPCPKDK-----------PVTGGIAKDAWEIPRESLRLNRKLGAGQFGEV 254

Query: 238 SEGLRESLS-SYISLAE 253
             G+  + +   +   +
Sbjct: 255 WAGVWNNTTQVAVKTLK 271


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  240 bits (611), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 77/275 (28%), Positives = 120/275 (43%), Gaps = 31/275 (11%)

Query: 2   GSLSSRGKTSSPSPSSSGP--------------DQEPVSMQPERHKVTAVALGSFPAGEQ 47
           GSL SR    +P P+  GP                 P  +     K   VAL  + + ++
Sbjct: 55  GSLDSR---YTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDE 111

Query: 48  ARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREK 102
           + LS   G+ + +I + + DWW V +  + +E  +P  +VA+     +  W +E + R++
Sbjct: 112 SDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKE 171

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR 162
           A++LLL   NP G FL+R S+     YSLSV+         ++HYRI+ LDNG  YI+  
Sbjct: 172 ADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATN 231

Query: 163 LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
            TFPSL ALV  YS+ A G+C  L  PC   +               P     ++     
Sbjct: 232 QTFPSLQALVMAYSKNALGLCHILSRPCPKPQPQMW--------DLGPELRDKYEIPRSE 283

Query: 223 LLFLEAPASGEASLLSEG-LRESLSSYISLAEDPL 256
           +  L     G    +  G  R S+   +    +  
Sbjct: 284 IQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGT 318


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  238 bits (607), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 70/226 (30%), Positives = 115/226 (50%), Gaps = 19/226 (8%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVS-GREYHMPSVYVAKVA-- 90
             V    + +     LS + G+ + IIS ++GDWW  +S+ + G+E ++PS YVA+    
Sbjct: 58  IYVGKYDYDSRTDDDLSFKKGDLMYIISTDEGDWWFARSKDTAGKEGYIPSNYVAEYKSL 117

Query: 91  --HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               W    + R +AE++L    N  G+FLIR+S+T  G +SLSV+       DR+RHYR
Sbjct: 118 DAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQ-----DRVRHYR 172

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           ++RL++G L+++ R TF  LH LV+HY    DG+CC L  PC+         +       
Sbjct: 173 VRRLEDGSLFVTRRSTFQILHELVDHYKIETDGLCCKLLYPCLQ-------AEKPQTAGL 225

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAE 253
           +  ++  W+     +  L    +G+   + EGL     S  +   +
Sbjct: 226 LRQANEEWEIEKTQIKLLRRLGAGQFGEVWEGLWNGTTSVAVKTLK 271


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  234 bits (597), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 74/248 (29%), Positives = 120/248 (48%), Gaps = 17/248 (6%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV 70
              +  ++G     V  + E  +   VAL  + A     L  + GE L II E G+WW  
Sbjct: 41  PPITSQNAGLLPGQVFQKMEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKA 100

Query: 71  QSEVSGREYHMPSVYVAKVAHG----WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
           +S  + +E  +PS YVA+        W Y+ ++R+ AE  LL P N  G++LIRES+T +
Sbjct: 101 RSLTTRKEGFIPSNYVAEADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSK 160

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
           G YSLS+R       D ++HY+I+ LDNG  YISP++TF  + ++++HY + +DG+C  L
Sbjct: 161 GSYSLSIRDVDAQGQDVVKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKL 220

Query: 187 REPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR-ESL 245
            + C   K      KD             W+    S+  ++   +G+   +       S 
Sbjct: 221 DKACEKPKAQKPWDKDA------------WEISKDSIKMVKKLGAGQFGEVWMAFYNNST 268

Query: 246 SSYISLAE 253
              +   +
Sbjct: 269 KVAVKTLK 276


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  230 bits (585), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 67/258 (25%), Positives = 115/258 (44%), Gaps = 19/258 (7%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           S +++ K +  S   S PDQ P        +++ +AL +F       LS   GE L +  
Sbjct: 20  SNATQPKPNISSNFQSKPDQPPPVPW-RPPEMSYIALYAFQGRNDGDLSFEKGEVLKVFD 78

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFL 118
           + GDWW   S  +  + ++P  YVA V      GW +   +R +A   L     P G FL
Sbjct: 79  QSGDWWVASSTRTNVQGYIPCNYVAPVNSLEVEGWFFGSCTRSEAIMRLQADNLPKGTFL 138

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNG--WLYISPRLTFPSLHALVEHYS 176
           +RES+TR G Y+L+VR +       I++YR+ +  +G    +I+P+  F ++  +V+ ++
Sbjct: 139 VRESETRPGTYALTVRETDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVIDVVKFHT 198

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
               G+C  L +PC  Q            P T       W+    SL  L+    G+   
Sbjct: 199 SQPGGLCSKLLKPCPKQ-----------TPNTRTLGHEVWELPRSSLKLLDKLGQGQFGA 247

Query: 237 LSEGLRES-LSSYISLAE 253
           + +G+ +  +   +    
Sbjct: 248 VWKGIYDGKVEVAVKTLR 265


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  228 bits (582), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 62/261 (23%), Positives = 111/261 (42%), Gaps = 23/261 (8%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           L+S    S  SP+S  P   PV+      +     +  + A     L++   E +TI+ E
Sbjct: 253 LASMRGPSGASPTSPAPASSPVAPAVVPERKQVRVMFDYIATAAGDLTIHKDEMITILEE 312

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLI 119
             +WW  Q++  G    +PS Y+ ++       W    +SR +A  +L +     G FL+
Sbjct: 313 RPNWWKAQNK-HGEVGFVPSNYLCRIQGLEGEPWFRGRISRAEAAAMLQIT-KQEGCFLV 370

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RES+T+ G Y+LS+     +  + +RHYRIQ ++ G  +++    F S+  L+E++    
Sbjct: 371 RESETQPGEYTLSL-----SHNEGVRHYRIQHIE-GQYFVNENHRFDSIPQLIEYHKLNG 424

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
            GI   LR              D   P++V      W+             SG+  ++ +
Sbjct: 425 GGIVTRLRR----------AINDANAPISVGLGHDMWELSRDEFELGRELGSGQFGIVQQ 474

Query: 240 G-LRESLSSYISLAEDPLDDA 259
              R   +  I + ++    A
Sbjct: 475 ARYRNGQAVAIKMMKEGKMSA 495


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  226 bits (576), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 66/265 (24%), Positives = 113/265 (42%), Gaps = 27/265 (10%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLGEPLT 59
           +G + S   +   S       +  ++  PE       VAL  F AG + +LSL+ GE + 
Sbjct: 155 LGGVHSSATSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVR 214

Query: 60  II--SEDGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNP 113
           I+  ++ G+W    S+ SG    +PS YV        H W +  +SR  AE LL    N 
Sbjct: 215 ILSYNKSGEWCEAHSD-SGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN- 272

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVE 173
            G+FL+RES++  G  S+S+R        R+ HYRI    +G ++++    F +L  LV 
Sbjct: 273 -GSFLVRESESSPGQRSISLRYE-----GRVYHYRISEDPDGKVFVTQEAKFNTLAELVH 326

Query: 174 HYS--ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPAS 231
           H+S      G+  PL  P         P ++ P    +      W+     ++       
Sbjct: 327 HHSVPHEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGG 378

Query: 232 GEASLLSEGLRESL--SSYISLAED 254
           G+   + E + +    +  +   ++
Sbjct: 379 GQYGEVYEAVWKRYGNTVAVKTLKE 403


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  225 bits (574), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 70/246 (28%), Positives = 114/246 (46%), Gaps = 25/246 (10%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGR------- 77
           S Q +RH    VAL  + A     LS R G+ L ++      WW  +     R       
Sbjct: 37  SPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQL 96

Query: 78  EYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSV 133
           + ++PS YVA+     A  W +  + R  AE+ LL   N  G+FLIRES++++G +SLSV
Sbjct: 97  QGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSV 156

Query: 134 RLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
                     ++HYRI+RLD G  +++ R  F +L+  V HY++ +DG+C  L +PC+  
Sbjct: 157 LD-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKI 211

Query: 194 KLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS-SYISLA 252
           ++                    W+    S+  L+   SG+   + EGL  + +   +   
Sbjct: 212 QVPAPFDLSYKT-------VDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTL 264

Query: 253 EDPLDD 258
           +    D
Sbjct: 265 KPGSMD 270


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  225 bits (573), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 118/257 (45%), Positives = 163/257 (63%), Gaps = 4/257 (1%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG++  +   S+   S +  +      Q    K   VAL +FP   Q  LS+  GE L I
Sbjct: 1   MGNIPCKKGYSAIEASLTNLEIN----QAAADKCIFVALYNFPLSGQTDLSIHFGEQLNI 56

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           +SEDGDW  V S  +G+E ++P+ YVAKV + WLY+G++REKAEELL++  N  G+FLIR
Sbjct: 57  LSEDGDWLKVSSASTGQECYLPTNYVAKVCNRWLYKGINREKAEELLMVNSNRSGSFLIR 116

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES+TR G Y+LS+R +   S D I+HYRI +LDNGW YI+PRLTF +L  +V++YSE+AD
Sbjct: 117 ESETRSGSYTLSIRKTNHTSRDSIKHYRIHQLDNGWFYIAPRLTFATLQDMVDYYSEVAD 176

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           GICC L EPCV+Q++     +    P+ V   +LNW KLD   LF +     E   LS G
Sbjct: 177 GICCTLTEPCVVQRVPNPVIQRPSEPIVVRKPTLNWTKLDSMDLFNKDDKLNEDCPLSLG 236

Query: 241 LRESLSSYISLAEDPLD 257
           LRE++SSY+ + +D   
Sbjct: 237 LREAVSSYMLMTQDSES 253


>UniRef50_UPI0000F2B3BE PREDICTED: similar to Src-like-adaptor 2 n=1 Tax=Monodelphis
           domestica RepID=UPI0000F2B3BE
          Length = 310

 Score =  224 bits (572), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 146/242 (60%), Positives = 182/242 (75%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSG 76
                +     +    K  AVAL SFPAGEQ  L LRLGEPL IIS++G+WW V SE + 
Sbjct: 58  GPVDRKLNDVQRARVSKDMAVALDSFPAGEQGELVLRLGEPLIIISDNGEWWRVLSEATS 117

Query: 77  REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS 136
           +EY +PS +VA+++ GWLYEGL+REKAE+LLLLP N GG+FLIRESQTRRG YSLSVRLS
Sbjct: 118 KEYVVPSSHVARISQGWLYEGLNREKAEDLLLLPSNHGGSFLIRESQTRRGAYSLSVRLS 177

Query: 137 RPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
           RP S D +RHYRI RL+NGW YISPRLTFPSL ALVEHY+E+AD +C  L EPC  +++G
Sbjct: 178 RPTSRDVVRHYRIHRLENGWFYISPRLTFPSLQALVEHYTEMADDLCSLLVEPCAFRRVG 237

Query: 197 PLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPL 256
            LPG++ PPPV+V   +LNWK++D SLLF E  +SG+   +S GLRE++ +YIS+ EDP 
Sbjct: 238 LLPGRNIPPPVSVQRPTLNWKEVDSSLLFSEVSSSGDTCPISVGLREAIGTYISMTEDPS 297

Query: 257 DD 258
            D
Sbjct: 298 LD 299


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  223 bits (569), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 67/234 (28%), Positives = 108/234 (46%), Gaps = 20/234 (8%)

Query: 30  ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV 89
           +      VA+  + A     L+   G+ L I  +  DWW  +S  +G++ ++P  YVA +
Sbjct: 62  DNTAKVVVAVYDYDARLDDDLTFVKGDLLEIREDTTDWWYARSRKNGKKGYIPGNYVAPI 121

Query: 90  A----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG----CYSLSVRLSRPASW 141
                  W +  + R  AE+LL+  G+  G+FLIR+S+ + G    C++LSVR       
Sbjct: 122 QTLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVRDK----- 176

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
           + IRHYRI+  D+G  +IS    F +L+ L+E Y   +DG+   L EPC       +   
Sbjct: 177 ELIRHYRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIKLLEPCRK-----VCIM 231

Query: 202 DTPPPVTVPTSS-LNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAE 253
                 T   S    W+    SL F     SG+   + +G+  S +   I   +
Sbjct: 232 FKKQVQTFGLSHKDKWEISRDSLEFQSRVGSGQFGDVYKGVWNSKIPVAIKSLK 285


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  223 bits (569), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 62/239 (25%), Positives = 103/239 (43%), Gaps = 26/239 (10%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPS 83
               E      VAL  F AG + +LSL+ GE + I+  ++ G+W    S+ SG    +PS
Sbjct: 182 PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPS 240

Query: 84  VYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            YV        H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R     
Sbjct: 241 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE--- 295

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQKLGP 197
              R+ HYRI    +G ++++    F +L  LV H+S      G+  PL  P        
Sbjct: 296 --GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYP-------- 345

Query: 198 LPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESL--SSYISLAED 254
            P ++ P    +      W+     ++       G+   + E + +    +  +   ++
Sbjct: 346 APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKE 404


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  223 bits (569), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 62/239 (25%), Positives = 103/239 (43%), Gaps = 26/239 (10%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPS 83
               E      VAL  F AG + +LSL+ GE + I+  ++ G+W    S+ SG    +PS
Sbjct: 201 PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPS 259

Query: 84  VYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            YV        H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R     
Sbjct: 260 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYD--- 314

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQKLGP 197
              R+ HYRI    +G ++++    F +L  LV H+S      G+  PL  P        
Sbjct: 315 --GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYP-------- 364

Query: 198 LPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESL--SSYISLAED 254
            P ++ P    +      W+     ++       G+   + E + +    +  +   ++
Sbjct: 365 APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKE 423


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  223 bits (567), Expect = 6e-57,   Method: Composition-based stats.
 Identities = 68/264 (25%), Positives = 115/264 (43%), Gaps = 26/264 (9%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPV-SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII- 61
           ++S  +    S ++    +E + +   E      VAL  F A     LS+  GE L ++ 
Sbjct: 33  VASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLG 92

Query: 62  -SEDGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGA 116
            + +G+W   Q++    +  +PS Y+  V     H W +  +SR  AE LL    N  G+
Sbjct: 93  YNHNGEWCEAQTK--NGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GS 148

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FL+RES++  G  S+S+R        R+ HYRI    +G LY+S    F +L  LV H+S
Sbjct: 149 FLVRESESSPGQRSISLRYE-----GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHS 203

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
            +ADG+   L  P         P ++ P    V  +   W+     +        G+   
Sbjct: 204 TVADGLITTLHYP--------APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGE 255

Query: 237 LSEGLRESLS--SYISLAEDPLDD 258
           + EG+ +  S    +   ++   +
Sbjct: 256 VYEGVWKKYSLTVAVKTLKEDTME 279


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  222 bits (566), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 26/240 (10%)

Query: 25  VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMP 82
                E      VAL  F AG + +LSL+ GE + I+  ++ G+W    S+ SG    +P
Sbjct: 189 EPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVP 247

Query: 83  SVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
           S YV        H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R    
Sbjct: 248 SNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE-- 303

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS--ELADGICCPLREPCVLQKLG 196
               R+ HYRI    +G ++++    F +L  LV H+S      G+  PL  P       
Sbjct: 304 ---GRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYP------- 353

Query: 197 PLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESL--SSYISLAED 254
             P ++ P    +      W+     ++       G+   + E + +    +  +   ++
Sbjct: 354 -APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKE 412


>UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A9JR87_DANRE
          Length = 264

 Score =  222 bits (566), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 102/258 (39%), Positives = 154/258 (59%), Gaps = 2/258 (0%)

Query: 1   MGSLSSRGKTSS-PSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGS  S+ +            +     +  E  +   V+L  +P+      ++R+GE L 
Sbjct: 1   MGSRPSKDRRGPNAHAVLLDTEDSNGPLTMESIRYVLVSLYDYPSRGPGDCAIRVGERLN 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+S++G+W+ V S  +G E ++PS Y AK+ + W + GLS+ K+EELL+LP N  G+FLI
Sbjct: 61  ILSDEGEWFKVSSSATGNESYIPSNYTAKLYNRWQFVGLSKRKSEELLMLPHNQPGSFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RES+T  G Y+LSVR S       ++HYRI  +DNGW YISP LTF +L  ++ HYS  +
Sbjct: 121 RESETFPGNYTLSVRKSGSQERASVKHYRISCIDNGWFYISPGLTFRTLSDMIAHYSV-S 179

Query: 180 DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           DG+CC L EPC +     +P  +  PPV V   ++NWK +D S++F +     E SL+SE
Sbjct: 180 DGLCCTLGEPCFIIGSNNVPVVNGAPPVAVKRPTINWKDVDSSMIFSQTKEGAEDSLVSE 239

Query: 240 GLRESLSSYISLAEDPLD 257
           GL+E+++SY+ + E   D
Sbjct: 240 GLKEAINSYLYMTEKCED 257


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  222 bits (565), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 73/245 (29%), Positives = 112/245 (45%), Gaps = 17/245 (6%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           +      + +  P    P Q          +   VA+  +       L    GE + I+ 
Sbjct: 25  NCPKPPVSQNFDPLIPYPSQYTPPPSSPLPENLVVAIYKYDPAHSDDLGFEKGEKMKILD 84

Query: 63  -EDGDWWTVQSEVSGREYHMPSVYVAKVAHG----WLYEGLSREKAEELLLLPGNPGGAF 117
            +D +W+  +S  +G+  ++P  +VAK+       W Y+ LSR  A   LL PGN  G+F
Sbjct: 85  CDDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSF 144

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           LIRES+T+ G +S+SVR   P   D I+HYRI+ +D G  YI+ +++F SL  LV+HYS 
Sbjct: 145 LIRESETQPGSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSR 204

Query: 178 LADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLL 237
            ADG+C  L +PC  +       +D             W+    SL        G+   +
Sbjct: 205 EADGLCTRLVKPCQTRAPQKPWWQD------------EWEVPRESLKLERRLGQGQFGEV 252

Query: 238 SEGLR 242
             G  
Sbjct: 253 WMGKY 257


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  221 bits (564), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 60/239 (25%), Positives = 97/239 (40%), Gaps = 21/239 (8%)

Query: 21  DQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYH 80
               +            +L  + A E   LSL  GE L I+ +  + W      +G+E +
Sbjct: 207 SPASLPPGAAPALFEVQSLYDYDALEPTDLSLSKGERLVIVDQMEEHWWKARNNAGQEGY 266

Query: 81  MPSVYVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           +P+ YV K    +  W     S+  A  LL + G   GAFL+RES++  G YSLSV    
Sbjct: 267 IPANYVRKLGLESEPWFMADTSKAMASALLNMCG-QDGAFLVRESESTPGSYSLSVFYQG 325

Query: 138 PASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGP 197
                +I+H      D     +S R TF S+  L+E++     G+   LR+P        
Sbjct: 326 KLKHYKIKH------DQDMYRVSERHTFASISELIEYHKHNGGGLVTRLRKPV------- 372

Query: 198 LPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS-SYISLAEDP 255
              +D   P+T       W+   R +       SG   ++  G+ +S     I + ++ 
Sbjct: 373 ---QDANTPITAGLGHDRWELDAREIELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEG 428


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  220 bits (561), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 70/269 (26%), Positives = 116/269 (43%), Gaps = 32/269 (11%)

Query: 2   GSLSSRGKTSSPSPS----SSGPDQEPV--SMQPERHKVTAVALGSFPAGEQARLSLRLG 55
           G+L S+G +++   S         +E +      E      VAL  F AG + +LSLR G
Sbjct: 95  GTLHSQGSSNTAQSSFENAHRWTSKENLLAPGPEEDDPQLFVALYDFKAGGENQLSLRKG 154

Query: 56  EPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLL 109
           E + I+  ++ G+W    S+ SG    +PS YV        H W +  +SR  AE LL  
Sbjct: 155 EQVRILSYNKSGEWCEAHSD-SGHVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSS 213

Query: 110 PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLH 169
             N  G+FL+RES++  G  S+S+R        R+ HYRI    +G +Y++    F +L 
Sbjct: 214 GIN--GSFLVRESESSPGQRSISLRYD-----GRVYHYRISEDSDGKVYVTAEAKFNTLA 266

Query: 170 ALVEHYS--ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            LV H+S      G+  PL  P         P ++ P    +      W+     ++   
Sbjct: 267 ELVHHHSVLHEGHGLITPLLYP--------APKQNKPTVFPLSPEPDEWEICRTDIVMKH 318

Query: 228 APASGEASLLSEGLRESL--SSYISLAED 254
               G+   + E + +    +  +   ++
Sbjct: 319 KLGGGQYGEVYEAVWKRYGNTVAVKTLKE 347


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  220 bits (560), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 78/281 (27%), Positives = 125/281 (44%), Gaps = 40/281 (14%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQP---------------ERHKVTAVALGSFPAGEQA 48
           + S+ ++  P+  +S     P                    +      VAL  + A  + 
Sbjct: 70  VKSKPQSCQPTNPTSNLAISPSHPSETQTVTTSKISGRSVKQLKPKHYVALFDYNARTEE 129

Query: 49  R--LSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREK 102
              LS R  E L +   D +WW VQ+  SGR+ ++PS +VAK     A  W    LSR+ 
Sbjct: 130 ETFLS-RRDEVLLLADTDSEWWLVQNLSSGRKGYVPSSFVAKKGSVEAEEWFMPMLSRKD 188

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR---PASWDRIRHYRIQRLDNGWLYI 159
           +E LLLL GN  G FL+RES+T +G  +LSVR          + ++HYRI+  D  + YI
Sbjct: 189 SERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTVKHYRIKHPDYRYYYI 248

Query: 160 SPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS---SLNW 216
           + + +F SL  L++ YS  + G+CC L   C+            PPP+T   S     +W
Sbjct: 249 TTKCSFSSLQELIQFYSIDSHGLCCKLTRACL-----------CPPPITSDLSVKTKDHW 297

Query: 217 KKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAEDPL 256
           +    S++ +E   +G+   + +G         +   +   
Sbjct: 298 EISKSSIVLIEKLGAGQFGEVWKGTWNGTTEVAVKTLKQGT 338


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  219 bits (559), Expect = 5e-56,   Method: Composition-based stats.
 Identities = 63/258 (24%), Positives = 109/258 (42%), Gaps = 25/258 (9%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGD 66
           +  + + +     +E +    E      VAL  F A     LS+  GE L ++  +++G+
Sbjct: 85  EPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGE 144

Query: 67  WWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
           W  V+S+    +  +PS Y+  V     H W +  +SR  AE LL       G+FL+RES
Sbjct: 145 WSEVRSK--NGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLL--SSLINGSFLVRES 200

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
           ++  G  S+S+R        R+ HYRI    +G +Y++    F +L  LV H+S +ADG+
Sbjct: 201 ESSPGQLSISLRYE-----GRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL 255

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
              L  P         P  + P    V      W+     +        G+   +  G+ 
Sbjct: 256 VTTLHYP--------APKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 307

Query: 243 ESLS--SYISLAEDPLDD 258
           +  S    +   ++   +
Sbjct: 308 KKYSLTVAVKTLKEDTME 325


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  218 bits (556), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 74/267 (27%), Positives = 109/267 (40%), Gaps = 38/267 (14%)

Query: 14  SPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQ 71
           S  +  P+     +      +   A   F    +  L  + G+ LTI +  ED +WW V+
Sbjct: 2   SARAKEPEGARPDILKPTKGMKCEAAYDFNGASKEDLPFKKGDILTIENPTEDPNWWLVR 61

Query: 72  SEVSGREYHMPSVYV-------------------AKVAHGWLYEGLSREKAEELLLLPGN 112
            + +GR   +P+ YV                     +   W +  +SRE AE LL+    
Sbjct: 62  -DKTGRTGMIPANYVELIGSDTKKTGTLPRDASGQLIPMPWFHGKISRELAESLLMP--R 118

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             G FL+RES    G Y+L V        D++ HYR+Q   NG L I   + F SL  LV
Sbjct: 119 EDGLFLVRESAHFPGDYTLCVCFQ-----DQVDHYRMQ-GKNGKLTIDEEVYFSSLEELV 172

Query: 173 EHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASG 232
           +HY + ADG+C  LR+P V Q                    +NW+   R ++      SG
Sbjct: 173 QHYEKDADGLCTRLRKPVVKQGGREFKIDA--------RKFVNWEISPREIVKSAQIGSG 224

Query: 233 EASLLSEGLRESLSSYISLAEDPLDDA 259
           +   + EGL       I   +D   DA
Sbjct: 225 QFGDVFEGLYRGQKVAIKTLKDVQGDA 251


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  218 bits (555), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 62/236 (26%), Positives = 102/236 (43%), Gaps = 25/236 (10%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVY 85
           Q +      VAL  F AG   +LSL+ GE + I+  ++ G+W        G+   +PS Y
Sbjct: 104 QEDDDPQLFVALYDFQAGGDNQLSLKKGEQVRILSYNKSGEWCEA-HASPGQVGWVPSNY 162

Query: 86  VAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           V  V     H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R       
Sbjct: 163 VTPVNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE----- 215

Query: 142 DRIRHYRIQR-LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPG 200
            R+ HYRI     +G +Y++    F +L  LV H+S  +DG+   L  P         P 
Sbjct: 216 GRVYHYRINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLITQLLYP--------APK 267

Query: 201 KDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAED 254
            + P    +      W+     ++       G+   + E + +  +    +   ++
Sbjct: 268 HNKPTVFALSPEPDEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKE 323


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  216 bits (551), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 60/267 (22%), Positives = 109/267 (40%), Gaps = 26/267 (9%)

Query: 5   SSRGKTSSPSPSSSGPDQ---------EPVSMQPERHKVTAVALGSFPAGEQARLSLRLG 55
           SS  KT  P P +   DQ            +          VAL  +       L LR G
Sbjct: 179 SSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKG 238

Query: 56  EPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK-----VAHGWLYEGLSREKAEELLLLP 110
           +   I+ E    W    + +G+E ++PS YV +       + W  + ++R +AE+LL   
Sbjct: 239 DEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQE 298

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI-RHYRIQRLDNGWLYISPRLTFPSLH 169
           G  GG F++R+S ++ G Y++SV          + RHY +        Y++ +  F ++ 
Sbjct: 299 GKEGG-FIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIP 356

Query: 170 ALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAP 229
            L+ ++   + G+   L+ P   Q        +   P T      +W+   + L FL+  
Sbjct: 357 ELINYHQHNSAGLISRLKYPVSQQ--------NKNAPSTAGLGYGSWEIDPKDLTFLKEL 408

Query: 230 ASGEASLLSEG-LRESLSSYISLAEDP 255
            +G+  ++  G  R      I + ++ 
Sbjct: 409 GTGQFGVVKYGKWRGQYDVAIKMIKEG 435


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  213 bits (543), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 64/260 (24%), Positives = 111/260 (42%), Gaps = 16/260 (6%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G+  +  + +  S    G  +        + + T VAL  + +     LS + G+ + ++
Sbjct: 42  GNEGTISQLNGTSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLL 101

Query: 62  SEDG-DWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGA 116
                DWW V+ + +G+  ++P  +VAK        W    + R +AE L+L    P G 
Sbjct: 102 DHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGT 161

Query: 117 FLIRESQTRRGCYSLSVRLSRPA-SWDRIRHYRIQRLD-NGWLYISPRLTFPSLHALVEH 174
           FLIRE +     ++L++R +    +   ++HY+I+RLD +   +I+ R TF SL  LV +
Sbjct: 162 FLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRY 221

Query: 175 YSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEA 234
           YS++ DG+CC L  P         P      P     +  NW+     L        G  
Sbjct: 222 YSDVPDGLCCQLTFP--------APRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNF 273

Query: 235 SLLSEGLRESL-SSYISLAE 253
             +  G    +    I   +
Sbjct: 274 GEVWYGKWRGIVEVAIKTMK 293


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  213 bits (543), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 63/261 (24%), Positives = 104/261 (39%), Gaps = 25/261 (9%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE- 63
            S+  +    PS                    V + +F    +  LS   GE LT++   
Sbjct: 39  PSQPGSRQRQPSHRADRYPREPQV----GDVFVGVYNFQGRTEPELSFERGEKLTLLRRL 94

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           D +WW ++S+ SG+E + PS Y+A       + W +  +SR  AE LL       G+FL+
Sbjct: 95  DENWWLMRSQRSGKEGYAPSNYIAPFKDINRNPWYHSNISRNTAEYLL--KSGVDGSFLV 152

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           RES +  G YS+++R    A      HYRI     G  +++    F ++  LV H++ +A
Sbjct: 153 RESLSSPGEYSITLRCDGKAR----THYRINHDARG-YFVAAGKFFATVEQLVAHHAVVA 207

Query: 180 DGICCPLR-EPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLS 238
           DG+   L+  P    +  PL        V        W+     ++       G+   + 
Sbjct: 208 DGLVACLKQHPVEKAEAKPL--------VLSKEEDEQWEIARSEIVLGHRLGEGQYGEVY 259

Query: 239 EGLRESLSSYISLAEDPLDDA 259
            G        I   +D   +A
Sbjct: 260 VGEWGPHRVAIKTIKDGAMEA 280


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  213 bits (541), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 63/261 (24%), Positives = 110/261 (42%), Gaps = 27/261 (10%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           L +      P+P +     +  S          VAL  F A E   LSL       +I +
Sbjct: 319 LDANMPGGIPTPGTPNSKAKDNSH----FVKLVVALYPFKAIEGGDLSLEKNAEYEVIDD 374

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKV------AHGWLYEGLSREKAEELLLLPGNPGGAF 117
             + W    +  G   ++PS YV          + W    +SR++AE LL   G+  G F
Sbjct: 375 SQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLL-KQGDKEGCF 433

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           ++R+S T+ G Y+LS+    P S   ++HY I++      Y+S +    ++  L+ ++  
Sbjct: 434 VVRKSSTK-GLYTLSLHTKVPQSH--VKHYHIKQNARCEYYLSEKHCCETIPDLINYHRH 490

Query: 178 LADGICCPLR-EPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
            + G+ C L+  PC           D P P T   S   W+     L+ +E   SG+  +
Sbjct: 491 NSGGLACRLKSSPC-----------DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGV 539

Query: 237 LSEG-LRESLSSYISLAEDPL 256
           +  G  R S+ + + + ++  
Sbjct: 540 VRRGKWRGSIDTAVKMMKEGT 560


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 59/270 (21%), Positives = 107/270 (39%), Gaps = 33/270 (12%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEP----------VSMQPERHKVTAVALGSFPAGEQARLSL 52
           +  S    S P PS+      P          V    E      V L  F  G + +L++
Sbjct: 81  NFPSDTIQSRPLPSTPTHATSPDIAGWNSTEDVCGGDEHDPDLFVVLYDFNGGVENQLTV 140

Query: 53  RLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEEL 106
           R G+ + I+  ++ G+W   +   +G+   +P  YV        H W +  +SR  AE L
Sbjct: 141 RKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPVTYVTPFNSLEKHSWYHGPISRNAAEYL 200

Query: 107 LLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFP 166
           L       G+FL+R+S++  G  S+S+R        R+ HYRI    +G ++++    F 
Sbjct: 201 L--SSGIDGSFLVRDSESSPGHRSISLRFD-----GRVYHYRISSGSDGKVFVTTESKFS 253

Query: 167 SLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFL 226
           ++  LV H+ + +DG+   LR P    +   + G    P          W+     +   
Sbjct: 254 TIAELVHHHCKQSDGLITTLRYPAAKMQKPIIYGVSPLP--------DEWEIERTDISMK 305

Query: 227 EAPASGEASLLSEGLRESLS--SYISLAED 254
                G+   + E + +  +    +    +
Sbjct: 306 NKLGGGQYGEVYEAIWKKHNKIVAVKTLRE 335


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  211 bits (537), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 63/257 (24%), Positives = 101/257 (39%), Gaps = 20/257 (7%)

Query: 14  SPSSSGPDQEPVSMQPE---RHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWW 68
           S S SG    P+S        +    VA   F    +  L  + G+ + I+  + D +W+
Sbjct: 2   SNSMSGNSGNPMSGNSSKNFPNGTECVARYDFKGNSEKDLPFKKGDIIEILQSTRDPNWY 61

Query: 69  TVQSEVSGREYHMPSVYVAK------VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
             +    GR   +P  YV +          W +  ++REKAEELL       G FL+RES
Sbjct: 62  NAKKVSDGRTGLIPINYVQQRRALHLHEMPWFFGKITREKAEELLTP--REVGLFLVRES 119

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
               G Y+L V    P +  ++ HYR+    +  + +     FP+L  L++HY + ADG+
Sbjct: 120 TNFPGDYTLCVVS--PQNNKKVEHYRVISTSDNQVTVDEEAFFPTLIELIKHYEKDADGL 177

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
           C  L++P   +                      W      + F E    GE   + +G+ 
Sbjct: 178 CTMLKKPLKKKTEILQSAIFK-----ESFQKEGWAVPIEDVEFKELIGKGEFGNVYKGVW 232

Query: 243 ESLSSYISLAEDPLDDA 259
              +  I    D    A
Sbjct: 233 AKKTVAIKKLRDDSKTA 249


>UniRef50_B6DVV3 Src tyrosine kinase 1 n=1 Tax=Aplysia californica
           RepID=B6DVV3_APLCA
          Length = 517

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 70/264 (26%), Positives = 117/264 (44%), Gaps = 33/264 (12%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G +     + + SPS+ G    P+   P R      AL +F A  Q  LS R G+ + I 
Sbjct: 32  GRVDLNASSGTSSPSTDGL--RPLPRVPAR--NRVRALYNFEAINQDDLSFRKGDLMEID 87

Query: 62  S---EDGDWWTVQSEVSGREYHMPSVYV------AKVAHGWLYEGLSREKAEELLLLPGN 112
               E  DWW      +  + ++PS YV       +    W      R++++++LLLPGN
Sbjct: 88  ETSPETDDWWLAVHLKTKNKGYIPSNYVAKDDATPQTQDWWF--EFDRKESDKMLLLPGN 145

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWD-RIRHYRIQR-LDNGWLYISPRLTFPSLHA 170
           P G FL+RE+ T +  Y LSVR +  AS +  ++HYR+++  D    +IS + TF +L  
Sbjct: 146 PRGTFLVREA-TDKSTYVLSVRDNDKASGEPCVKHYRVRKMDDERGYFISAKKTFKTLFD 204

Query: 171 LVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
           ++EHY + +DG+CC L   C   +                      +     +       
Sbjct: 205 VIEHYKDNSDGLCCQLGAACPRSRPTVQ--------------FRELEIKREVIELTNKLG 250

Query: 231 SGEASLLSEG-LRESLSSYISLAE 253
           +G    + +G LR+ +   +   +
Sbjct: 251 AGCFGEVWKGKLRKVVEVAVKTLK 274


>UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_HUMAN
          Length = 276

 Score =  209 bits (533), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 103/245 (42%), Positives = 145/245 (59%), Gaps = 9/245 (3%)

Query: 13  PSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQS 72
              S+  P + P+             L  +P+ + +    R GE L +IS++G WW   S
Sbjct: 4   SMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAIS 63

Query: 73  EVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
             +GRE ++P + VA+V HGWL+EGL R+KAEELL LP    G+F+IRES+T++G YSLS
Sbjct: 64  LSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLS 123

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
           VR        +++HYRI RL N W YISPRLTF  L  LV HYSE+ADG+CC L  PC+ 
Sbjct: 124 VRHR------QVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLT 177

Query: 193 QKLGPLPGKDTPPPVTVPTSSLNWKKLDR---SLLFLEAPASGEASLLSEGLRESLSSYI 249
           Q       + +  PVT+   +++W+++ R        E P   + SL S GLRES++SY+
Sbjct: 178 QSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYL 237

Query: 250 SLAED 254
           SL  +
Sbjct: 238 SLTSE 242


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 71/259 (27%), Positives = 108/259 (41%), Gaps = 34/259 (13%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWT 69
           S+ SP  SG    P+            AL S+    Q  LS + G+ + +IS   D WW 
Sbjct: 16  STVSPGGSGVQARPLVQ--------VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWF 67

Query: 70  VQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +   +G   ++PS YV            W    + R +A+  LLL GNP G +LIR S 
Sbjct: 68  ARHSDTGISGYIPSNYVCLNDGLPTSLDAWY--NIGRREADRKLLLVGNPKGTYLIRPS- 124

Query: 124 TRRGCYSLSVRLSRPASWD-RIRHYRIQ-RLDNGWLYISPRLTFPSLHALVEHYSELADG 181
           +    Y+LSVR          ++HYRI+   +NG  +IS R TFP++  LV +Y+   DG
Sbjct: 125 SETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDG 184

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL 241
           +CC L  PC      P+  +D              +    S+  +     G    +    
Sbjct: 185 LCCRLSIPCPRAYRPPVQFRDF-------------EINRDSITRIRKLGQGTFGEVYLAK 231

Query: 242 RES-LSSYISLAEDPLDDA 259
               +   + +  DP D +
Sbjct: 232 WNGSVEVAVKMRLDPTDRS 250


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  206 bits (524), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 58/253 (22%), Positives = 105/253 (41%), Gaps = 21/253 (8%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISED 64
           ++  K    +   + P     +  PE       AL ++ A     L L+ GE L ++S +
Sbjct: 167 TTTAKAEPRAEEEAPPRPPKSAAPPEVVLFEVTALFNYNATNPDDLDLKQGETLEVLSTE 226

Query: 65  GDWWTVQSEVSGREYHMPSVYVAKV---AHGWLYEGLSREKAEELLLLPGNPGGAFLIRE 121
            ++W      +G+   +PS YVAK    +  W    +SR +A+  L +  N  G FL+RE
Sbjct: 227 EEFWWRARNSAGKVGMIPSNYVAKPGFESEPWYVGKMSRVEAQSKLQIF-NLDGTFLVRE 285

Query: 122 SQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG 181
           S+T  G Y+LSV  +      RI+H      D    YI+ R    ++  L++++     G
Sbjct: 286 SETSAGSYTLSVYFNGQPRNYRIQH------DGNEYYITTRHRQKTIKELIDYHKLNGGG 339

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL 241
           +C  L++P            D   P      S  W+     +   +   SG+  ++ +G 
Sbjct: 340 LCTRLKKP----------ACDDEAPTPHDLGSDKWEIDPSEISLGKVLGSGQFGVVYKGK 389

Query: 242 RESL-SSYISLAE 253
            + +    +   +
Sbjct: 390 FQGVTDVAVKKVK 402


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score =  206 bits (523), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 66/265 (24%), Positives = 116/265 (43%), Gaps = 21/265 (7%)

Query: 1   MGSLSSRGKTSSPS--PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPL 58
           +  LS++ ++++    PS   P       +    K+   AL  F   E   L+LR  E  
Sbjct: 50  LSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEY 109

Query: 59  TIISE-DGDWWTVQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPG 111
            I+ + +  WW  + +  G E  +PS YV +        + W +  ++R +AE LL    
Sbjct: 110 LILEKYNPHWWKAR-DRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQES 168

Query: 112 NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHAL 171
              GAF++R+S    G Y++SV +   ++   I+HY+I++ D+G  Y++ R  F S+  L
Sbjct: 169 KE-GAFIVRDS-RHLGSYTISVFMGARSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPEL 226

Query: 172 VEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPAS 231
           + ++   A G+   LR P  L             P T   S   W+     L F++   S
Sbjct: 227 IWYHQHNAAGLMTRLRYPVGLMGSCL--------PATAGFSYGKWEIDPSELAFIKEIGS 278

Query: 232 GEASLLSEGLRES-LSSYISLAEDP 255
           G+  ++  G   S +   I    + 
Sbjct: 279 GQFGVVHLGEWRSHIQVAIKAINEG 303


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  205 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 64/269 (23%), Positives = 114/269 (42%), Gaps = 27/269 (10%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
            ++   +  + S +     P    P+   +   VAL  +       L++  G+   I+  
Sbjct: 128 PTQQPANFLNNSVAHMRNNPSHNSPQIPTEGQFVALHDYVKRVDDDLNMTKGQIFNILDN 187

Query: 64  DG-DWWTVQSEVSGREYHMPSVYV----AKVAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
              DWW  +   +G   ++P  ++    +  ++ W +  L R +AE  L LPGN  G+FL
Sbjct: 188 SHCDWWYAECVSTGNRGYVPKNHLAAVTSLESNEWYFGELKRIEAEHYLQLPGNDHGSFL 247

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNG------WLYISPRLTFPSLHALV 172
           +R S+++   YSLSVR       + ++HYRI+   +         YIS +L F ++  LV
Sbjct: 248 VRISESQSSEYSLSVR-----EENTVKHYRIRSRYSRTDPTLKRFYISRQLPFVNIQQLV 302

Query: 173 EHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS-LNWKKLDRSLLFLEAPAS 231
            HY E   G+CC L +PC+            P PV +       W+    S++  E    
Sbjct: 303 NHYLENQSGLCCRLGKPCIRPT--------HPEPVGLSHKLIDKWEIPKSSIILKEKIGQ 354

Query: 232 GEASLLSEGLRESLS-SYISLAEDPLDDA 259
           G+   + + +    +   +   +    DA
Sbjct: 355 GQFGEVFKAVWNKTTIVAVKTLKPSSCDA 383


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score =  204 bits (519), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 71/259 (27%), Positives = 108/259 (41%), Gaps = 34/259 (13%)

Query: 11  SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD-WWT 69
           S+ SP  SG    P+            AL S+    Q  LS + G+ + +IS   D WW 
Sbjct: 100 STVSPGGSGVQARPLVQ--------VRALYSYQGHNQDDLSFQKGDIMFVISGMSDAWWF 151

Query: 70  VQSEVSGREYHMPSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
            +   +G   ++PS YV            W    + R +A+  LLL GNP G +LIR S 
Sbjct: 152 ARHSDTGISGYIPSNYVCLNDGLPTSLDAWY--NIGRREADRKLLLVGNPQGTYLIRPS- 208

Query: 124 TRRGCYSLSVRLSRPASWD-RIRHYRIQ-RLDNGWLYISPRLTFPSLHALVEHYSELADG 181
           +    Y+LSVR          ++HYRI+   +NG  +IS R TFP++  LV +Y+   DG
Sbjct: 209 SETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTVHPDG 268

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL 241
           +CC L  PC             P     P   + +  +  S+  +     G    +    
Sbjct: 269 LCCRLSIPC-------------PRAYRPPVHFVMFAIIRDSITRIRKLGQGTFGEVYLAK 315

Query: 242 RES-LSSYISLAEDPLDDA 259
               +   + +  DP D +
Sbjct: 316 WNGSVEVAVKMRLDPTDRS 334


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score =  204 bits (518), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 54/254 (21%), Positives = 91/254 (35%), Gaps = 27/254 (10%)

Query: 16  SSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVS 75
           S+   D+    +     +   +AL  + A     L+ + G+ + I+ +  +W   Q    
Sbjct: 44  STPIQDRPAPPIPQIEEEDIYIALYDYVARTNKDLTFKKGDTMVILKKGQNWSIAQLLEP 103

Query: 76  GR-----EYHMPSVYVAKV-----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
                  E  +P+ YV K         W+++   R +A  LL+ P N  G FL R   T 
Sbjct: 104 NPLYSVTEGSIPTNYVKKQSSVVSQPSWMFDTADRSEAVSLLMQPCNNHGDFLARRRTTN 163

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCP 185
              Y+LSVR     +   + H +I+++      I     F +L+ LV +Y E        
Sbjct: 164 PNEYALSVR-----NGATVNHIKIEKMGGQGYSIDHHTMFATLNDLVGYYQENMLANDIR 218

Query: 186 LREPCVLQKLGPLPGKDTPPPVTVPTSS---LNWKKLDRSLLFLEAPASGEASLLSEGLR 242
           LR PC    +          P T   S      W+   +S+   E    G    + +GL 
Sbjct: 219 LRSPCKQVVME--------SPQTAGLSHDLADEWEIDRKSIELKEKLGKGNFGEVYKGLW 270

Query: 243 ES-LSSYISLAEDP 255
                  +      
Sbjct: 271 NGTTRVAVKKMIKS 284


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score =  200 bits (509), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 61/263 (23%), Positives = 103/263 (39%), Gaps = 22/263 (8%)

Query: 5   SSRGKTSSPSPSSSG--PDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           SS  K   P+P +    P       + +  +   VA+  F A E   L L  G+   I+ 
Sbjct: 151 SSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILE 210

Query: 63  EDGDWWTVQSEVSGREYHMPSVYV------AKVAHGWLYEGLSREKAEELLLLPGNPGGA 116
           ++   W    +  G E ++PS YV          + W    ++R KAE+LL      GG 
Sbjct: 211 KNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGG- 269

Query: 117 FLIRESQTRRGCYSLSVRLSRPASW-DRIRHYRIQRLDN--GWLYISPRLTFPSLHALVE 173
           F++R+S ++ G Y++S+            RHY I+         Y++ +  F S+  ++E
Sbjct: 270 FMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIE 328

Query: 174 HYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGE 233
           ++   A G+   LR P  ++            P T   S   W+     L F+    SG 
Sbjct: 329 YHKHNAAGLVTRLRYPVSVKG--------KNAPTTAGFSYEKWEINPSELTFMRELGSGL 380

Query: 234 ASLLSEG-LRESLSSYISLAEDP 255
             ++  G  R      I    + 
Sbjct: 381 FGVVRLGKWRAQYKVAIKAIREG 403


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  200 bits (509), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 56/238 (23%), Positives = 100/238 (42%), Gaps = 32/238 (13%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVS-----------GREYHMP 82
            VAL  F    + +LSLR G+ + I+  +++ +W   +   +           G    +P
Sbjct: 120 FVALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVP 179

Query: 83  SVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
           S ++A       + W +  +SR  +E +L       G+FL+RES+T  G Y++SVR    
Sbjct: 180 SNFIAPYNSLDKYTWYHGKISRSDSEAIL--GSGITGSFLVRESETSIGQYTISVRHD-- 235

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
               R+ HYRI   +   ++I+  + F +L  LV H+S  ADG+ C L  P   +  G  
Sbjct: 236 ---GRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRG 292

Query: 199 PGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAED 254
                      P +   W+     ++       G+   + EG  +       +   ++
Sbjct: 293 LF------SLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKE 344


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  200 bits (508), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 56/259 (21%), Positives = 98/259 (37%), Gaps = 21/259 (8%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           GS  +     + +           +  P +  +    + S  A     LS+  G+ L +I
Sbjct: 208 GSPPAFTAIPTGNAPPLSLPPRSPAPPPAQKMLEVRVMYSHNATTPGDLSITEGDKLWVI 267

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVAK---VAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
            +    W    +  GR  ++PS YV +    +  W +  +SR +A  LL       G FL
Sbjct: 268 DQSEPNWWKARDSQGRVGYIPSNYVRQAGIESEAWFHGRISRAEAAALL-HVAKQEGCFL 326

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           +RES+++ G YSLSV     +  D +RHY I++      YI+ R  FP +  L+E++   
Sbjct: 327 VRESESKVGEYSLSV-----SHGDSLRHYHIKKEGE-EFYINDRHRFPDICKLIEYHKLN 380

Query: 179 ADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLS 238
           + G+   LR+             D   P         W+             SG+  ++ 
Sbjct: 381 SGGLVTRLRK----------SIADLHTPAAAGLGHGKWELDPADFAIGRQLGSGQFGVVH 430

Query: 239 EGLR-ESLSSYISLAEDPL 256
           E          + + +   
Sbjct: 431 EATYIGEKKVAVKMMKQGT 449


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  199 bits (507), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 53/238 (22%), Positives = 95/238 (39%), Gaps = 20/238 (8%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA 87
                    VAL          LS+R  + L  +  DG W   +  ++  E  +P  +VA
Sbjct: 272 PDTSEGKVVVALYDNDPRGDMELSMRKDDYLLELRSDGAWVQCRHLMTNEEGFVPGTFVA 331

Query: 88  KVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
                    W +  ++R KAE+LL +P    G FLIRES++  G +SLS++       + 
Sbjct: 332 PYKSLEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKD-----GEN 386

Query: 144 IRHYRIQRLDNG-WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           +RH+R++++  G  L  SP      L +L++++     G+   L+ PC  +   P  G  
Sbjct: 387 VRHFRVKKVAGGIKLQGSPSSPHKDLPSLIKYHKRHRGGLTTTLKVPCPREIRAPDIGYA 446

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAEDPLDDA 259
                        W+    +++  +    G+   + +G         I   +     A
Sbjct: 447 VK---------DKWEVDRDTIVLEKQLGEGQYGEVYKGRWNGTTEVAIKTLKSAATSA 495


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  199 bits (506), Expect = 8e-50,   Method: Composition-based stats.
 Identities = 61/240 (25%), Positives = 98/240 (40%), Gaps = 30/240 (12%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSV 84
                     +A  +F    +  L    G+ LTI+  ++D +W+  +++V GRE  +P+ 
Sbjct: 5   QAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPAN 63

Query: 85  YVAKVA----------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
           YV K              W +  ++RE+AE LL  P    G FL+RES    G Y+L V 
Sbjct: 64  YVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVS 121

Query: 135 LSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK 194
                   ++ HYRI    +  L I   + F +L  LVEHY+  ADG+C  L +P V++ 
Sbjct: 122 CD-----GKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEG 175

Query: 195 LGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                 +              W    + L  L+    GE   +  G        +   ++
Sbjct: 176 TVAAQDE---------FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKN 226


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  196 bits (499), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 65/269 (24%), Positives = 98/269 (36%), Gaps = 32/269 (11%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDG 65
           GK     P + GP  E  S+    +  T   +  F  G +  L  + G+ L +I  + D 
Sbjct: 7   GKLIDTGPVTRGPSYENHSLTTIPNGTTCEGVFDFNTGNKGDLPFKKGDTLVVIQRTRDP 66

Query: 66  DWWTVQSEVSGREYHMPSVY---------------VAKVAHGWLYEGLSREKAEELLLLP 110
           +W+  Q+   G    +P  Y               V   A  W +  ++R  AE+LL   
Sbjct: 67  NWYRAQN-SKGESGMVPLNYITQSNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLLTP- 124

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHA 170
               G FL+RES    G Y++ V          + HYR+   DN  + I     F +L  
Sbjct: 125 -RKDGLFLVRESTNYPGDYTMCVSF-----AGEVEHYRVIFKDN-KVTIDEEEYFENLTK 177

Query: 171 LVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
           LVEHY   ADG+ C L +P + +      G       T       W      L       
Sbjct: 178 LVEHYERDADGLVCTLTQPLIKK------GGHEYSVDTEEFRKSGWAINFTDLKLGTILG 231

Query: 231 SGEASLLSEGLRESLSSYISLAEDPLDDA 259
            G+   + EG  +     +   +D    A
Sbjct: 232 KGDFGDVYEGTYKDQKVAVKSVKDRSKAA 260


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  196 bits (499), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 52/239 (21%), Positives = 95/239 (39%), Gaps = 22/239 (9%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPS 83
           M   +     VAL  + +  +  LS   G+   I+     D  WW  Q+  + ++  +P 
Sbjct: 1   MSATKKNDIFVALDDYASQHKGELSFSKGDNFKILKNAAPDDGWWNAQNLNTKKKGWIPC 60

Query: 84  VYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
             VA         W +  +SR  A+ LL   G   G +L+RESQ++ G Y+L V     +
Sbjct: 61  SLVALDGSLELFDWCHGAISRNGADYLLKQHG-IDGMYLVRESQSQPGQYTLDVWKEGKS 119

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLP 199
                 HYRI + D G+ +    + FP++  L++H+   +DG+C  L            P
Sbjct: 120 -----VHYRITKGDEGYFFRQG-VCFPTIPELIQHHQTRSDGLCSSLDH--------IAP 165

Query: 200 GKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
                  V        W+     ++  +    G    + +G+  + +  I   ++   +
Sbjct: 166 KAHAKTIVIGMDMEKKWELKRSEVILGDRLGGGNYGEVFKGIYNNKTVAIKTIKEESME 224


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  196 bits (498), Expect = 7e-49,   Method: Composition-based stats.
 Identities = 58/233 (24%), Positives = 106/233 (45%), Gaps = 21/233 (9%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA 87
           +P+      +A+  +P  E+  L L  G+ +T+     ++W    +  G E ++PS YV 
Sbjct: 250 EPKPSDFDVIAMYDYPGLERGDLPLVKGQRVTVFDATREFWWRARDEQGSEGYIPSNYVK 309

Query: 88  KV---AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           K+   +  W +  LSR +AE +L   G  GG F++R S +R   Y+LS+         ++
Sbjct: 310 KMGLDSEEWFFPQLSRTRAENILKGEGREGG-FVVRNS-SRENMYTLSI-----CHEGQV 362

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           RHY I+  ++   +IS +  FPS+  L+E++     G+   LR+P         P +  P
Sbjct: 363 RHYHIKLDESNKYFISEKHRFPSIKELIEYHKLNGGGLVTRLRKP---------PVQLAP 413

Query: 205 PPVTVPTSSLN-WKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAEDP 255
            P ++       W+    SL   +   SG+   +  G  +  +   I +  + 
Sbjct: 414 NPQSLGPLFDEAWEIDKVSLSLGKELGSGQFGRVVSGKWKGKIDVAIKMMREG 466


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  195 bits (495), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 72/263 (27%), Positives = 106/263 (40%), Gaps = 32/263 (12%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERH----KVTAVALGSFPAGEQARLSLRLGEPLTI 60
            + G+    +P S  P+ +PV   P           +AL  F A     LS+R G+ L  
Sbjct: 21  PAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCA 80

Query: 61  ISEDGDWWTVQSEVSGRE-YHMPSVYVAK------VAHGWLYEGLSREKAEELLLLPGNP 113
           + E G +   +          +P  +VAK          W + G+SR +A++LLL P N 
Sbjct: 81  LEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNE 140

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVE 173
            GAFLIR S++  G YSLSVR        ++ HYR+    +G LY+     FP L  L+ 
Sbjct: 141 PGAFLIRPSESSLGGYSLSVRAQA-----KVCHYRVSMAADGSLYLQKGRLFPGLEELLT 195

Query: 174 HYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGE 233
           +Y      I  PL +PC+ QK                     W++             G 
Sbjct: 196 YYKANWKLIQNPLLQPCMPQKA---------------PRQDVWERPHSEFALGRKLGEGY 240

Query: 234 ASLLSEGLR-ESLSSYISLAEDP 255
              + EGL   SL   I + +  
Sbjct: 241 FGEVWEGLWLGSLPVAIKVIKSA 263


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  193 bits (491), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 57/228 (25%), Positives = 94/228 (41%), Gaps = 26/228 (11%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV----QSEVSGREYHMPSVYVAKVA 90
             V L  F +     LS R G+   +  ++  WW      ++  +  + ++P  Y+A+  
Sbjct: 12  KYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERE 71

Query: 91  ----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                 W +  +SR +A   L   GN  GAFLIR S+     Y LSVR ++      +RH
Sbjct: 72  TVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRH 126

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPP 206
           Y+I R   G L+++  ++F SL  LV ++   +      L  PC   +  PLP  D    
Sbjct: 127 YKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWD---- 182

Query: 207 VTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE-SLSSYISLAE 253
                   +W++            SG    + EGL +  +   I +  
Sbjct: 183 --------DWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVIS 222


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  193 bits (489), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 57/237 (24%), Positives = 102/237 (43%), Gaps = 21/237 (8%)

Query: 31  RHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDG--DWWTVQSEVSGREYHMPSVYV-- 86
               T VAL     G    + LR G+ L  +++D   +W  V++ V+G +  +P+ ++  
Sbjct: 169 PAVDTFVALYDHTPGCAKEMLLRAGDMLLRVNKDPSKEWTLVENCVTGCQGFVPTSFIAA 228

Query: 87  --AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
             +  +H W +  ++R KAE+ L  P    G+FLIRES++  G YSLS+R       D +
Sbjct: 229 SASLESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRD-----GDTV 283

Query: 145 RHYRIQRLDNGWLYISPRL--TFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           RHYR++  + G   +       F SL  L+  + +   G+   LREPC  +         
Sbjct: 284 RHYRVENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATALREPCPKESAPMASDLT 343

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR-ESLSSYISLAEDPLDD 258
                        W+    S+   +   +G+   +  G+  +S    +   +    +
Sbjct: 344 FDT-------HDQWEVPRTSIKLGKLLGTGQYGEVYSGIFQDSTKVAVKTLKAASAN 393


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  191 bits (486), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 66/268 (24%), Positives = 98/268 (36%), Gaps = 56/268 (20%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKV- 89
               +   +FP      L  + G+ L I+  S+D +W+  + E  G E  +P  YV +  
Sbjct: 8   GTECIGKYNFPGSSPHDLPFKKGDRLVIVAPSKDPNWYKARRE-DGLEGMIPFNYVQEKV 66

Query: 90  ---------------------------------------AHGWLYEGLSREKAEELLLLP 110
                                                     W +  +SRE AE+LL  P
Sbjct: 67  PVAGSAPQPPQRPVLSAPQPVADNDAAMNHASKGAVQLKTMPWFHGRISREDAEKLLTPP 126

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHA 170
            N  G FL+RESQ   G Y+L V         R+ +YR++R + G + +     F +L  
Sbjct: 127 KN--GRFLVRESQNYPGDYTLCVSYD-----GRVENYRVRRNEKGLVTVDDDEYFDNLIK 179

Query: 171 LVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
           LVEHY + ADG+C  L+ P   +      G+              W     SLL      
Sbjct: 180 LVEHYQKEADGLCTRLKAPVDKE------GQHLFVVDVNDFKEKGWAIPKASLLKKSLIG 233

Query: 231 SGEASLLSEGLRESLSSYISLAEDPLDD 258
            GE   +  G  E     +   +D L D
Sbjct: 234 KGEFGEVWLGDYEGKKVAMKSMKDHLKD 261


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  190 bits (483), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 56/234 (23%), Positives = 94/234 (40%), Gaps = 23/234 (9%)

Query: 28  QPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTV-QSEVSGR--EYHMPSV 84
               +    +AL  F A     LS + G+   I    GDWWT  + ++ GR     +P  
Sbjct: 63  SANNNAAIYMALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTGFVPYN 122

Query: 85  YVAKV---AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           Y+A+    +  W +  ++R  A   L+   N  G+FL+R S++    Y LSVR    A  
Sbjct: 123 YLARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAK- 181

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
               H++I +  +   Y+     F S+  ++EHY      I   L EPC+  K   +P  
Sbjct: 182 ----HFKIFQTGD-QFYVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCIRIKPENVP-- 234

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESL-SSYISLAED 254
                   P S+  W+             SG  + +  G  ++     I + ++
Sbjct: 235 --------PPSTDEWELPKEEFQLENQLGSGHFADVYSGKWKNHSKVAIKILKN 280


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  189 bits (481), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 60/255 (23%), Positives = 102/255 (40%), Gaps = 22/255 (8%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWW 68
            +     +       P+   PE      VA   FP  E   L L  G    I+ +    W
Sbjct: 173 PSPQLHKNCPSALSRPLPPVPEF--QQVVAKFDFPGIEAQDLPLVKGCTYVILDDKNPHW 230

Query: 69  TVQSEVSGREYHMPSVYVAK------VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
               +  GRE  +PS YV          + W  + ++R KAE+LL   G+  G+FL+RES
Sbjct: 231 WRAQDEEGREGLIPSTYVYPLTRFDLEQNRWFCKDITRAKAEQLLRQAGSE-GSFLVRES 289

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI 182
            ++ G  ++SV    P   + ++HY +++L  G  Y++ + TF ++  L+ ++   A G+
Sbjct: 290 -SQVGKLTVSVYSCIPC--EVVKHYHVKQLPTGEWYLAEKHTFSTISDLIHYHQHNAAGL 346

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR 242
              LR P                P T   S   W+     L  L     G   ++  G+ 
Sbjct: 347 VTRLRHPVRP---------GEELPSTAGLSYGKWELDALELTSLRELGRGALGVVQLGMW 397

Query: 243 ESLS-SYISLAEDPL 256
             +    I +  + +
Sbjct: 398 RGVRHIAIRMLHEGV 412


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  189 bits (480), Expect = 7e-47,   Method: Composition-based stats.
 Identities = 62/253 (24%), Positives = 108/253 (42%), Gaps = 30/253 (11%)

Query: 16  SSSGPDQEPVS-MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSE 73
             + P QEPV    P   KVTAV    +    ++ L L+ G+   I + E+ +WW  Q  
Sbjct: 97  GPATPKQEPVKCFIPINTKVTAV--YDYQPKSKSELQLKQGDVFVITNSENENWWEAQPV 154

Query: 74  VSG-REYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC 128
            +      +PS YV K     +  + +  + R  AE  L    N  G+FL+RESQ+  G 
Sbjct: 155 GNSDIVGWVPSNYVVKLNSLDSEPYYHGRIPRTTAEFFLSNGIN--GSFLVRESQSNAGE 212

Query: 129 YSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
           +++S+R        ++ HYRI R D G  +I+    F ++  LV+ Y + +DG+  PLR 
Sbjct: 213 HTISLRCD-----GKVFHYRISRTDKGV-FIAADRVFSTVQDLVKFYHQQSDGLVHPLRH 266

Query: 189 PCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS-- 246
                +                  S  W+    S++      +G+   + E +  + +  
Sbjct: 267 AVPKNRQEITAS-----------PSDKWEIDRSSIMMGTRLGAGQYGEVYEAVLTNKNRH 315

Query: 247 SYISLAEDPLDDA 259
             +   ++   +A
Sbjct: 316 VAVKTLKEEAMEA 328


>UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QLS5_SCHMA
          Length = 801

 Score =  189 bits (479), Expect = 9e-47,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 106/216 (49%), Gaps = 16/216 (7%)

Query: 31  RHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAKV 89
             +   VA+  + A     +S R G+ L ++   D +WW V+   SG+  ++PS Y+A+ 
Sbjct: 333 NSEYYHVAIFDYEAHTSEEVSARKGDQLRVLDLSDSEWWLVEH--SGQVGYIPSSYLAQA 390

Query: 90  A----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
                  W +  +SR+ +E LLLL GN  G FL+R S+T  G  SLSVR +     + ++
Sbjct: 391 NSVEAEDWYFRSISRKDSERLLLLKGNIRGTFLVRASETTNGALSLSVRDTEQQRGETVK 450

Query: 146 HYRIQRLDN-GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           HY+I++      +YI+ +  FP L +LV HYS  ADG+CC L          P P     
Sbjct: 451 HYKIKQSSETNDVYITTKQVFPDLKSLVIHYSNQADGLCCCLT--------RPCPRPPPV 502

Query: 205 PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           P      +   W+    SL  +E   +G+   + +G
Sbjct: 503 PTDLSRLTRDQWEISRSSLKLIELLGAGQFGEVWKG 538


>UniRef50_Q9H6Q3-2 Isoform 2 of Src-like-adapter 2 n=3 Tax=Homininae RepID=Q9H6Q3-2
          Length = 210

 Score =  187 bits (475), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 145/178 (81%), Positives = 154/178 (86%), Gaps = 1/178 (0%)

Query: 1   MGSLSSRGKTSSPSPSSSGPD-QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
           MGSL SR K+      SS    Q PV+M+ ER K TAVALGSFPAG  A LSLRLGEPLT
Sbjct: 1   MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           I+SEDGDWWTV SEVSGREY++PSV+VAKV+HGWLYEGLSREKAEELLLLPGNPGGAFLI
Sbjct: 61  IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           RESQTRRG YSLSVRLSRPASWDRIRHYRI  LDNGWLYISPRLTFPSL ALV+HYSE
Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178


>UniRef50_Q3ZB94 Src-like-adaptor 1 n=7 Tax=Clupeocephala RepID=Q3ZB94_DANRE
          Length = 271

 Score =  186 bits (472), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 104/256 (40%), Positives = 147/256 (57%), Gaps = 19/256 (7%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG+++ +G T+  S S     +            T V L  +P  + +    ++G+ L  
Sbjct: 1   MGNVTRQGHTNPESNSLDSMFK---------DCDTLVVLADYPCRDISEPVFKMGDRLKG 51

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           +SEDG WW V+S  +G E ++P  +V+KV HGWL+EG+SR+KAEELL LPGN  G+FLIR
Sbjct: 52  LSEDGCWWKVRSLQTGTENYIPCNHVSKVYHGWLFEGVSRQKAEELLSLPGNSAGSFLIR 111

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES   RG YSLSVR         ++HY+I RL N W YISPRLTF  L  +V HYS+ +D
Sbjct: 112 ESPRERGLYSLSVRHRS------VKHYKIFRLTNSWYYISPRLTFQCLEDMVNHYSDSSD 165

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFL-EAPASGE--ASLL 237
           GICC L  PC+             PPV V   +L+W K+ +S L       S +   +++
Sbjct: 166 GICCVLSAPCLALSNPTPSSIQGAPPV-VMRRNLDWNKVKKSQLLNPSELDSVDSRDNMM 224

Query: 238 SEGLRESLSSYISLAE 253
           S G+R S+++Y+SL  
Sbjct: 225 SYGVRSSIAAYLSLTS 240


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  186 bits (472), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 64/267 (23%), Positives = 104/267 (38%), Gaps = 24/267 (8%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQP-----ERHKVTAVALGSFPAGEQARLSLRLGE 56
           G  +S  KT +  P+++      V         E       AL S+ A     LS + GE
Sbjct: 19  GLFTSPDKTEAEKPTNTAKQTVNVPNPSRASACEPGSELYKALWSYKARGADELSFQEGE 78

Query: 57  PLTIISEDGDWWTVQSEVSGR----EYHMPSVYVAKVA----HGWLYEGLSREKAEELLL 108
              I    G+WWT               +P+ ++A+        W +  L+R + E LLL
Sbjct: 79  QFRICERQGEWWTALKLGRDGAVTGRGFVPNHFLARRQTVKEQPWYFGTLNRFETEILLL 138

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSL 168
            P N  GAFL+R S+     Y LSV     +    ++H +I +  N   Y+    TF SL
Sbjct: 139 APENDVGAFLVRHSEKDNIGYVLSVLSGDRSRE--VKHIKIHQNQNESFYLDKSQTFQSL 196

Query: 169 HALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
             LV++Y + +      L++PC      P P        TV     +W+         E 
Sbjct: 197 EKLVDYYWKYSLDGDSFLKQPCRR----PEPKPKDLSHSTVN----DWELPKEEFTLEEE 248

Query: 229 PASGEASLLSEGLRES-LSSYISLAED 254
              G  + +  G  +  ++  I + ++
Sbjct: 249 LGKGFFADVYRGKWKGMVNVAIKILKN 275


>UniRef50_Q4RNL0 Chromosome 21 SCAF15012, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RNL0_TETNG
          Length = 509

 Score =  185 bits (469), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 62/259 (23%), Positives = 93/259 (35%), Gaps = 76/259 (29%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAK---- 88
              +AL  + A  +  LS R GE   II+  +GDWW  +S  +G   ++PS YVA     
Sbjct: 4   TLFIALYDYDARTEDDLSFRKGEKFHIINNTEGDWWEARSLDTGNSGYIPSNYVAPVDSI 63

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQT------------------------ 124
            A  W +  + R+ AE  LL  GN  G FLIRES+T                        
Sbjct: 64  QAEEWYFGKMGRKDAERQLLAHGNQRGTFLIRESETTKGEHSHAHTLRQLPGRGLYVGYT 123

Query: 125 -------RRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP--RLTFPSLHALVEHY 175
                    G YSLS+R       D ++HY+I++LDNG  YI+   +   P L  L    
Sbjct: 124 SVPLHSRFPGAYSLSIRDWDDNKGDHVKHYKIRKLDNGGYYITTSCKRGMPKLADL---- 179

Query: 176 SELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEAS 235
                                               +   W+    SL  ++   +G+  
Sbjct: 180 ---------------------------------SVKTKDMWEIPRESLQLIKKLGNGQFG 206

Query: 236 LLSEGLRES-LSSYISLAE 253
            +  G+        +   +
Sbjct: 207 EVWMGMWNGTTKVAVKTLK 225


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  185 bits (469), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 57/240 (23%), Positives = 95/240 (39%), Gaps = 33/240 (13%)

Query: 31  RHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSG------------ 76
             +   V L    +  + +LSLR G  L ++  +   +W   +   +G            
Sbjct: 7   TDEEFFVVLYPIESAGRNQLSLRKGCQLRVLRYNGTEEWCEAKVLSTGDPSDNAKCAVVG 66

Query: 77  REYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
               +PS Y+        H W +  +SR  AE LL    N  G+FL+R+S++ RG  S+S
Sbjct: 67  SVGWVPSNYITPATSLNMHTWYHGAVSRAAAEYLLSSGIN--GSFLVRDSESCRGHLSVS 124

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
           VR +       + HYRI     G  YISP   F +L  LV H+S  +DG+   L  P   
Sbjct: 125 VRFNAS-----VYHYRINVDTAGLFYISPEHRFQTLPELVHHHSYASDGLAAILHYP--- 176

Query: 193 QKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLA 252
                      P   ++      W+     +   +    G+   + E + +  +  I++ 
Sbjct: 177 -----AAKSTKPAVYSMAPDYDEWEIDRSEIHMKQRLGGGQYGDVYEAVWKRYNKTIAVK 231


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  183 bits (465), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 64/231 (27%), Positives = 103/231 (44%), Gaps = 24/231 (10%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPV-SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII- 61
           ++S  +    S ++    +E + +   E      VAL  F A     LS+  GE L ++ 
Sbjct: 285 VASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLG 344

Query: 62  -SEDGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGA 116
            + +G+W   Q++    +  +PS Y+  V     H W +  +SR  AE LL    N  G+
Sbjct: 345 YNHNGEWCEAQTK--NGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEHLLSSGIN--GS 400

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FL+RES++  G  S+S+R        R+ HYRI    +G LY+S    F +L  LV H+S
Sbjct: 401 FLVRESESSPGQRSISLRYE-----GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHS 455

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            +ADG+   L  P         P ++ P    V  +   W+     +    
Sbjct: 456 TVADGLITTLHYP--------APKRNKPSVYGVSPNYDKWEMERTDITMKH 498


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  183 bits (463), Expect = 7e-45,   Method: Composition-based stats.
 Identities = 58/226 (25%), Positives = 94/226 (41%), Gaps = 20/226 (8%)

Query: 31  RHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKV- 89
                 V++  +     + +  + GE   ++    DW  VQSE SG + ++PS  +    
Sbjct: 4   PASPRYVSISEYNPKHNSDIPCKGGEAFYLLERTDDWCYVQSETSGSKGYLPSHLIQLDL 63

Query: 90  -AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               W +  + R +AE LL       G FLIRES+T +G Y+L++ +       +I H+R
Sbjct: 64  TNEPWFHGNIGRIEAENLLQYS--EPGTFLIRESETIKGSYTLTM-IQIKDGTKQISHFR 120

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I   D+G  +I+    F  LH L++HY + +DG+ C L  P              P P  
Sbjct: 121 INY-DDGKYFITSARRFLGLHQLIQHYMQNSDGLACNLVYP-------------QPKPSI 166

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAE 253
                  W+     L       SG    + +G L  S +  I   +
Sbjct: 167 EYMELDVWEIDRGRLKLETKLGSGGFGDVWKGTLDGSFTVAIKQLQ 212


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  181 bits (460), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 67/154 (43%), Positives = 92/154 (59%), Gaps = 4/154 (2%)

Query: 29  PERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           PE      VAL  +       LS + GE + ++ E G+WW  +S  + RE  +PS YVAK
Sbjct: 109 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLSTKREGFIPSNYVAK 168

Query: 89  VA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           V       W ++ ++R+ AE  LL PGN  GAFLIRES+T +G YSLSVR   P   D I
Sbjct: 169 VNTLETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDVI 228

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           +HY+I+ LDNG  YISPR+TFP +  ++++Y   
Sbjct: 229 KHYKIRSLDNGGYYISPRITFPCISDMIKYYQTN 262


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  181 bits (460), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 58/307 (18%), Positives = 106/307 (34%), Gaps = 70/307 (22%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPA----GEQARLSLRLGEPL 58
           + S+    +   P++        S   +      +AL  F        Q+++ +  G+ L
Sbjct: 25  NTSTSWIQNHNPPTNFKGSVAHTSQINQPSDQLLIALFDFTPPNTLENQSQVRVEKGDRL 84

Query: 59  TII--SEDGDWWTVQSEVSGREYHMPSVY------------------------------- 85
            +   S DGDW  V+   +     +P+ Y                               
Sbjct: 85  QLFGYSADGDWSDVECIRTNERGWIPTNYTGRIPVPPNDHSTTLNTGSASGSSLTFQHTS 144

Query: 86  ---------------VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
                          V   +  W +  + R  AE LL       G+FLIRES++  G  +
Sbjct: 145 SHDVSCNGSQGSLARVGLESEKWYHGAIQRSYAEYLLN--SGITGSFLIRESESHPGQLT 202

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPC 190
           +S+R        +I HYRI R D+   Y+     F S+  LV H+ + +DG+ C L  P 
Sbjct: 203 ISLRYE-----GQIWHYRIHRDDSNMYYVIESNKFTSVSDLVHHHEKHSDGLACTLLYP- 256

Query: 191 VLQKLGPLPGKDTPPPVTVPTSSLNW-KKLDRSLLFLEAPASGEASLLSEGLRESLS--S 247
                   P +D          S +  +     ++      SG+  ++ E + +  +   
Sbjct: 257 -------APKRDRTSSELRMDPSFDIREIDRTEIVMKHKLGSGQYGVVYEAVWKPYNVLV 309

Query: 248 YISLAED 254
            +   ++
Sbjct: 310 AVKTLKE 316


>UniRef50_Q4SUZ3 Chromosome 21 SCAF13835, whole genome shotgun sequence. (Fragment)
           n=4 Tax=Tetraodontidae RepID=Q4SUZ3_TETNG
          Length = 232

 Score =  179 bits (455), Expect = 6e-44,   Method: Composition-based stats.
 Identities = 95/250 (38%), Positives = 140/250 (56%), Gaps = 20/250 (8%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           MG++         + +  G  + P        +V  V L  +P+ E      R+GE L +
Sbjct: 1   MGNVFRSLSERPGANACEGAFKAP--------EVDLVVLQDYPSAEVCEPIYRMGEKLKL 52

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           ++++   W V+S  + +E ++P+ +VAKV HGWL+EG+ R+KAEELL LPGN  G+F++R
Sbjct: 53  VAQEAYGWRVRSVQTRQENYIPASHVAKVYHGWLFEGVERQKAEELLSLPGNRVGSFMVR 112

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES   RG YSLSV+         ++HYRI RLDN W YISP LTF  L  ++ HY    D
Sbjct: 113 ESTRERGSYSLSVKYRS------VKHYRIYRLDNSWYYISPSLTFQCLEDMINHYC---D 163

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           G+CC L  PC+   L   P   T PPV +  +    K   R L  +E   + + S+LS G
Sbjct: 164 GLCCALTSPCLSASLPAPPTSATAPPVVMRRNFTWQKVNRRQLTSVE---NCDDSVLSYG 220

Query: 241 LRESLSSYIS 250
           +R S+++Y+S
Sbjct: 221 VRNSIAAYLS 230


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  178 bits (451), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 64/231 (27%), Positives = 103/231 (44%), Gaps = 24/231 (10%)

Query: 4   LSSRGKTSSPSPSSSGPDQE-PVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII- 61
           ++S  +    S ++    +E  ++   E      VAL  F A     LS+  GE L ++ 
Sbjct: 372 VASDFEPQGLSEAARWNSKEDLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLG 431

Query: 62  -SEDGDWWTVQSEVSGREYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGA 116
            + +G+W   Q++    +  +PS Y+  V     H W +  +SR  AE LL    N  G+
Sbjct: 432 YNHNGEWCEAQTK--NGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GS 487

Query: 117 FLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYS 176
           FL+RES++  G  S+S+R        R+ HYRI    +G LY+S    F +L  LV H+S
Sbjct: 488 FLVRESESSPGQRSISLRYE-----GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHS 542

Query: 177 ELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            +ADG+   L  P         P ++ P    V  +   W+     +    
Sbjct: 543 TVADGLITTLHYP--------APKRNKPTVYGVSPNYDKWEMERTDITMKH 585


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score =  176 bits (445), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 71/176 (40%), Positives = 97/176 (55%), Gaps = 7/176 (3%)

Query: 13  PSPSSSG--PDQEPVSMQP-ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWT 69
           P P + G  P     S+ P        +AL S+       L    GE L I+ + G+WW 
Sbjct: 98  PHPVTPGFLPIPARFSLMPLVFTDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWK 157

Query: 70  VQSEVSGREYHMPSVYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
            QS  +G+E  +P  +VAK        W ++ LSR+ AE  LL PGN  G+FLIRES++ 
Sbjct: 158 AQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESEST 217

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG 181
            G +SLSVR       + ++HY+I+ LDNG  YISPR+TFP LH LV HY+   +G
Sbjct: 218 AGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTRYYNG 273


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score =  176 bits (445), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 60/228 (26%), Positives = 105/228 (46%), Gaps = 34/228 (14%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAKVA- 90
           +   VAL +F +  +A LS   GE L ++S  DG WW V+S ++ +  ++P+ YV K   
Sbjct: 35  ENIYVALFNFTSNNEAELSFSCGEQLELLSISDGSWWKVRSLLTNKIGYIPNNYVEKYDY 94

Query: 91  ---HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
              + W    + R  A   LL  G   G+FL+R+S ++ G Y+LS+      +   ++HY
Sbjct: 95  LKKYDWYTGVMGRSSANLALLSNG-SAGSFLVRKSTSKPGDYTLSL-----HNETSLKHY 148

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            I++  N   YI     F +L +LVEHY +++ G+   L++ C  +KL            
Sbjct: 149 HIKKTKNCTFYILKEE-FSNLPSLVEHYKKVSGGLPRTLKDACSQKKL------------ 195

Query: 208 TVPTSSLNWKKLDRSLLFLEA-PASGEASLLSEG-LRESLSSYISLAE 253
                   W      +   +     G   ++ EG L  S++  + + +
Sbjct: 196 --------WDIPHNKITLTKKHLGKGNFGIVLEGRLFSSVNVAVKVLK 235


>UniRef50_UPI00016E52F9 UPI00016E52F9 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E52F9
          Length = 588

 Score =  175 bits (444), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 55/248 (22%), Positives = 102/248 (41%), Gaps = 33/248 (13%)

Query: 15  PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDG-DWWTVQSE 73
            S     Q P        +   +AL  +       L L  G    +I++   DWWTV++ 
Sbjct: 151 ASKKPLPQLPDPKVNADSERIVIALQEYVPSRDTDLPLEKGHEYILINKSNIDWWTVRNS 210

Query: 74  VSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSV 133
                            +GW  + ++R +A+ELL+  G   GAF++R+S +  G Y++SV
Sbjct: 211 -----------------NGWYSKNMNRMQAQELLMREGKE-GAFMVRDS-SHMGVYTVSV 251

Query: 134 RLSRPASWD----RIRHYRIQRLDNGW--LYISPRLTFPSLHALVEHYSELADGICCPLR 187
               P+       +++HY+I++ + G    Y++    F ++  L+ ++   A G+   LR
Sbjct: 252 FTKAPSQSGEKNPKVKHYQIRQTETGAGPFYLAENYLFNTIPELIHYHQHNAAGLITRLR 311

Query: 188 EPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSS 247
            P         P   +   V+ P  +  W+     L   +   SG+  L+ EG  +    
Sbjct: 312 HPVS-------PDGSSAQQVSAPFEADQWELNPDELTLGQEIGSGQFGLVLEGWWKKKKV 364

Query: 248 YISLAEDP 255
            + +  D 
Sbjct: 365 AVKMIRDG 372


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  174 bits (441), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 63/232 (27%), Positives = 103/232 (44%), Gaps = 22/232 (9%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQS-EVSGR---EYHMPSVYVAK 88
                AL +F + +   LS R G+   ++S   DWW+V+  + SGR      +P  Y+A 
Sbjct: 1   GSIYRALWAFQSQQGEHLSFREGDLFRVLSRRDDWWSVRRIDASGRVLDSGLVPGNYLAP 60

Query: 89  ----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
                   W +  L+R +A+  LL P N  GAFLIR S+     Y LSVR     S D++
Sbjct: 61  AESGQTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVR-----SGDQV 115

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           +HY++ + D    Y+ P   F SL  LV++Y + +     PL  PC    L         
Sbjct: 116 KHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLS-------- 167

Query: 205 PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAEDP 255
            P  +P  ++ W+   +     E   SG  + +  G  ++ +   + + +  
Sbjct: 168 TPALLPFPTIGWELPKKEFELEEELGSGCFARVYRGRWKNLIRVAVKILKSA 219



 Score =  157 bits (396), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 44/175 (25%), Positives = 71/175 (40%), Gaps = 10/175 (5%)

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           P          W Y  ++R KAE+LLL   N  G+FL+R S++    Y++S R     S 
Sbjct: 239 PLGTSLGWTGPWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISAR-----SE 293

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
            ++ H+RIQR   G  ++S R++F +L  L+ +Y      +   L EPC  Q+       
Sbjct: 294 GKVFHFRIQRSSIGAYFVSDRISFATLGELISYYQRNNRSLGVLLEEPCAQQRPLTPSLL 353

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR--ESLSSYISLAED 254
                +        W++       L     G    + E L   E+    I   + 
Sbjct: 354 CLQREL---FDMEPWERPREEFRLLRKLGEGHFGEVWEALWSTENRRVAIKTLKQ 405



 Score =  115 bits (288), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 39/146 (26%), Positives = 64/146 (43%), Gaps = 14/146 (9%)

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSL 168
            P N  GAFLIR S+     Y LSVR     S D+++HY++ + D    Y+ P   F SL
Sbjct: 730 APENSEGAFLIRVSEKDNVGYVLSVR-----SGDQVKHYKVLQTDQNRFYVEPGRRFSSL 784

Query: 169 HALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
             LV++Y + +     PL  PC    L          P  +P  ++ W+   +     E 
Sbjct: 785 AELVDYYQKTSLNNAGPLGNPCKRNTLS--------TPALLPFPTIGWELPKKEFELEEE 836

Query: 229 PASGEASLLSEGLRES-LSSYISLAE 253
             SG  + +  G  ++ +   + + +
Sbjct: 837 LGSGCFARVYRGRWKNLIRVAVKILK 862


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  173 bits (439), Expect = 4e-42,   Method: Composition-based stats.
 Identities = 47/178 (26%), Positives = 77/178 (43%), Gaps = 17/178 (9%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           +   +   H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R        
Sbjct: 3   TPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE-----G 55

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           R+ HYRI    +G LY+S    F +L  LV H+S +ADG+   L  P         P ++
Sbjct: 56  RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--------APKRN 107

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAEDPLDD 258
            P    V  +   W+     +        G+   + EG+ +  S    +   ++   +
Sbjct: 108 KPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME 165


>UniRef50_UPI0000ECD739 Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow
           tyrosine kinase gene in chromosome X protein)
           (Epithelial and endothelial tyrosine kinase) (ETK)
           (NTK38). n=2 Tax=Gallus gallus RepID=UPI0000ECD739
          Length = 633

 Score =  169 bits (429), Expect = 7e-41,   Method: Composition-based stats.
 Identities = 41/256 (16%), Positives = 90/256 (35%), Gaps = 17/256 (6%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHK---VTAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
           K   P P +    +  +      +K     AVA  ++     + + +       ++ E+ 
Sbjct: 160 KPLPPVPQTLKLRRRSLPQVVSSNKGILNMAVAQCNYEPSGNSAIRVVKSNKYHVLQEED 219

Query: 66  DWWTVQSEVSGREYHMPSVYV---AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
             W    ++ G E  +PS  +    K    W   G+SR ++E+LL       G F +  +
Sbjct: 220 FAWWKVRDLEGNEGFVPSTCLAGQKKNQEIWYVAGISRAQSEQLLHQSPKISG-FTVALA 278

Query: 123 Q-TRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG 181
           Q +R     +            ++HY + +      Y++    F ++  L+ ++   + G
Sbjct: 279 QMSRLYTSKMKSPFYGENKKGTVKHYHVHKTPENKYYLTENHCFETIPKLINYHQHNSAG 338

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL 241
           +   LR     Q            P T    +  W+     ++ L    SG+   +  G 
Sbjct: 339 MVPRLRHVVSTQI--------NKVPATASLGNGIWELKREEIVPLRELGSGQFGAVHLGK 390

Query: 242 RES-LSSYISLAEDPL 256
            +      + + ++ +
Sbjct: 391 WKGLYDVAVKMIKEGV 406


>UniRef50_UPI000186E29F tyrosine-protein kinase Src42A, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E29F
          Length = 466

 Score =  169 bits (427), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 68/262 (25%), Positives = 92/262 (35%), Gaps = 68/262 (25%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQP---ERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
            S+  T    P        PV         +    VAL  + A     LS R GE L I+
Sbjct: 35  PSQVATHDAVPEVRNGPMPPVPEPDGTNNSNAKMFVALYDYDARTDEDLSFRKGELLEIL 94

Query: 62  SE-DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           ++  GDWW  +S  S                           +E+ LLLP N  GAFLIR
Sbjct: 95  NDTQGDWWLARSSSS--------------------------DSEKKLLLPENEHGAFLIR 128

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           +S++RR  YSLSVR       D ++HYRI            +  F +L  LVEH      
Sbjct: 129 DSESRRNDYSLSVRD-----GDTVKHYRI--DIRRRWIFCSKNNFRTLQELVEH------ 175

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS---LNWKKLDRSLLFLEAPASGEASLL 237
                                    PVT   S      W+   +SL F+     G+   +
Sbjct: 176 ---------------------TIEKPVTGGLSHSTRDQWEIDRKSLKFVRKLGHGQFGDV 214

Query: 238 SEGLRESLS-SYISLAEDPLDD 258
            EGL  + +   I   +    D
Sbjct: 215 WEGLWNNTTPVAIKTLKPGTMD 236


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  163 bits (412), Expect = 6e-39,   Method: Composition-based stats.
 Identities = 51/249 (20%), Positives = 83/249 (33%), Gaps = 29/249 (11%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEV 74
              P    +  +        +        +   L+ R G+ +TI+   E+  W+ V+   
Sbjct: 34  HPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHT 93

Query: 75  SGREY----------HMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQT 124
           SG+E              S         W +  +S ++A + L  P    G FL+RES  
Sbjct: 94  SGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPP--EDGLFLVRESAR 151

Query: 125 RRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICC 184
             G Y L V   R      + HYR+    +G L I   + F +L  +VEHYS+    IC 
Sbjct: 152 HPGDYVLCVSFGRD-----VIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICT 205

Query: 185 PLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES 244
            L  P           +          +   W    + L        GE   + +G    
Sbjct: 206 KLVRPKRKHGTKSAEEE---------LARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG 256

Query: 245 LSSYISLAE 253
               +   +
Sbjct: 257 QKVAVKNIK 265


>UniRef50_C4PYM5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYM5_SCHMA
          Length = 670

 Score =  162 bits (409), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 53/273 (19%), Positives = 86/273 (31%), Gaps = 60/273 (21%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAKV- 89
                A  +F   +   L     E L II+  +D +W   ++   G    +P  YV +  
Sbjct: 14  GDVVKANYTFKKDKNEDLPFSKNETLEIINIGKDPNWAHAKN-AFGETGLIPLNYVQRKA 72

Query: 90  -------AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR-------- 134
                   H W +  +SR ++E LL   G+P G+FLIRES    G  +L V         
Sbjct: 73  DILENLKDHCWYHGRISRAESESLL--SGSPVGSFLIRESDLYSGGLTLCVVGPACAVGS 130

Query: 135 ----------LSRPASWDRIRHYRIQRLD-------------------NGWLYISPRLTF 165
                     ++ P +   ++HYRI R                          +     F
Sbjct: 131 PDTTEHQNSTVTPPNTMTNVQHYRIVRRPFKATPSNQHSEYSTPLICSKIHYTLDETDWF 190

Query: 166 PSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF 225
            SL  LV+ YSE   G+ C L  P            D             +    + +  
Sbjct: 191 SSLLELVQFYSEPKRGLVCALLHPVP----------DMQRKRLSELQKFGYLIFRKEIAL 240

Query: 226 LEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
            +    GE   + +         + + +     
Sbjct: 241 GDRIGRGEFGEVLKATYRGRQVAVKIYKKTASK 273


>UniRef50_UPI0000E4736E PREDICTED: similar to src-family protein tyrosine kinase n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4736E
          Length = 387

 Score =  161 bits (406), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 16/171 (9%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                 W +   SR+ AE+ L+  G   G F++R+     G + LSVR + P   D ++H
Sbjct: 1   MSSDFCWDFGMCSRQDAEKKLMAIGINKGQFIVRDRD--PGTFELSVRDNNPQKGDHVKH 58

Query: 147 YRIQRLDNG-WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           YRI ++D G   +I     FP++  LV HY   +DG+CC L E C  +            
Sbjct: 59  YRIWKMDGGNSFFIFQGSVFPTVSELVRHYQMNSDGLCCKLTEACPKEN----------- 107

Query: 206 PVTVPTSSLNWKKLDRSL-LFLEAPASGEASLLSEGLRESLS-SYISLAED 254
           P T+      W+   +SL         G+   + +G+    +   +   ++
Sbjct: 108 PNTIGLGKDKWETPRKSLGQMNRRLGEGKFGEVWQGVWNGNTPVAVKTLKE 158


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  159 bits (402), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 7/146 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R KAEE+L       GAFLIRES++  G +SLSV+       + ++H+++ R  
Sbjct: 61  FFGKIPRAKAEEMLSKQ-RHDGAFLIRESESAPGDFSLSVKF-----GNDVQHFKVLRDG 114

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++   + F SL+ LV+++   +
Sbjct: 115 AGKYFLWV-VKFNSLNELVDYHRSTS 139


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  159 bits (401), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 7/146 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS + G+ L +++E+ D    ++E++G++  +P  Y+    H W
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +  + R KAEE+L       GAFLIRES++  G +SLSV+       + ++H+++ R  
Sbjct: 61  FFGKIPRAKAEEMLSKQ-RHDGAFLIRESESAPGDFSLSVKF-----GNDVQHFKVLRDG 114

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++   + F SL+ LV+++   +
Sbjct: 115 AGKYFLWV-VKFNSLNELVDYHRSTS 139



 Score = 53.6 bits (127), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 20/73 (27%), Positives = 27/73 (36%), Gaps = 7/73 (9%)

Query: 21  DQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREY 79
           D E V  QP        AL  F   E   L  R G+ + ++ + D +WW       G+  
Sbjct: 150 DIEQVPQQPTY----VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA--CHGQTG 203

Query: 80  HMPSVYVAKVAHG 92
             P  YV  V   
Sbjct: 204 MFPRNYVTPVNRN 216


>UniRef50_B7QBP3 Protein tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7QBP3_IXOSC
          Length = 626

 Score =  158 bits (399), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 54/242 (22%), Positives = 94/242 (38%), Gaps = 23/242 (9%)

Query: 25  VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSV 84
           V++Q         AL SF A E+  LSL  G    ++ + G+ W    + SG    +PS 
Sbjct: 172 VALQVTTPARVVTALYSFQAIEKGDLSLEAGREYVVLDDSGEHWWQVRDGSGAVGFIPSN 231

Query: 85  YVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
           YV +      H W    +SR++AE++L       GAF++R S T+ G ++LS+  +   +
Sbjct: 232 YVEQKAGLWQHEWYAGDMSRQRAEQVLRQETKE-GAFVVRNSSTQ-GFFTLSLLANSIMN 289

Query: 141 WD-----RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKL 195
                  +   ++I+  D    Y+          +++       D   C  R  C   + 
Sbjct: 290 SWASSLFKSLRHKIEATDQ---YLETSYALNHAMSIMVFERRGKD---CLFRNSCYYCQN 343

Query: 196 GPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
                    P  T   S   W+     L  LE   SG+  ++  G  R      + + ++
Sbjct: 344 SC-----CQPDSTNNPSLDKWEIDPSELALLEELGSGQFGVVRRGKWRGCRDVAVKMMKE 398

Query: 255 PL 256
             
Sbjct: 399 GT 400


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 41/187 (21%), Positives = 71/187 (37%), Gaps = 11/187 (5%)

Query: 73  EVSGREYHMPSVYVAKVAHG---WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
             +G++  +   YVA        W +  ++RE  E++L   G   G FL+R+S    G Y
Sbjct: 23  NTNGKQTSVDRRYVANNEQHPKLWYHGNITREHTEKIL--SGQADGTFLVRDSTNFPGDY 80

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           +L +         ++ HYRI +L NG L      TF +L  L+ HY   ADG+C  L  P
Sbjct: 81  TLCMAF-----NGKVEHYRIYQL-NGILTCDHEETFDNLTQLIAHYKRDADGLCHRLITP 134

Query: 190 CVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYI 249
            +          ++           +       +   +    GE   +  G  +     +
Sbjct: 135 VISDDYRITRDNESLEERIRFFREASLIISRSEIRLGDIIGHGEFGDVLLGDYDGQRVAV 194

Query: 250 SLAEDPL 256
            + +   
Sbjct: 195 KVLKRSE 201


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 45/168 (26%), Positives = 70/168 (41%), Gaps = 8/168 (4%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  ++REKAEELL       G FL+RES    G Y+L V    P +  ++ HYR+  
Sbjct: 31  NWFFGKITREKAEELLTP--REVGLFLVRESTNFPGDYTLCVVS--PQNNKKVEHYRVIS 86

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
            ++  + +     FP+L  L++HY   ADG+C  L++P   +    L             
Sbjct: 87  TNDNRVTVDEDAFFPNLIELIKHYERDADGLCTMLKKPLKKKTEMVLQSAIFK----ESF 142

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
               W      + F E    GE   + +G+    +  I    D    A
Sbjct: 143 QKEGWAVPIEDVEFKELIGKGEFGDVYKGVWAKKTVAIKKLRDDSKTA 190


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score =  156 bits (395), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 33/168 (19%), Positives = 70/168 (41%), Gaps = 12/168 (7%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR-PASWDRIRHYR 148
            + W    +SR ++E+LL   G   GAF++R S ++ G Y++S+           ++HY 
Sbjct: 293 DYDWFAGNISRSQSEQLLRQKGKE-GAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHYH 350

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           +       LY++    F S+  L+ ++   + G+   LR P   +            P +
Sbjct: 351 VHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKA--------NKVPDS 402

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYISLAEDP 255
           V   +  W+     +  L+   SG+  ++  G  +      + + ++ 
Sbjct: 403 VSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEG 450


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  156 bits (395), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 19/165 (11%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  + RE+AE LL       G FL+RES    G Y+L V        +++ HYRI+
Sbjct: 376 MPWFHGRIKREEAENLL--KPREDGLFLVRESTNFPGDYTLCVCF-----NEKVEHYRIK 428

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             +N  L I     F +L  LVEHY+  +DG+C  L +    ++      +D        
Sbjct: 429 YAEN-KLTIDDDEYFDNLGQLVEHYTLDSDGLCTKLMKALPKEEFCVKDFQDN------- 480

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDP 255
                W+     L   E    GE   +  G+ +     + + +D 
Sbjct: 481 ----GWEIKMEDLQLKENIGKGEFGDVMLGILKGEKVAVKVLKDA 521


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score =  153 bits (386), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 47/250 (18%), Positives = 79/250 (31%), Gaps = 56/250 (22%)

Query: 52  LRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAK--------------------- 88
            R  + + I+  + D  W+  ++     E  + +  V +                     
Sbjct: 69  FRKDDHVRILGNTSDPAWYRARNASH-EEGLVHADCVVRVNGQSYENGIVRMRASGCDPG 127

Query: 89  ----------------VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
                               W +  +SRE  E+LL   G P G FL+RES    G ++L 
Sbjct: 128 AASTASSTSSHHSSVANNQPWFHSMISRENTEKLLR--GKPDGTFLVRESTNFPGDFTLC 185

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP--C 190
           +         ++ HYRI++   G L       F +L  LV HY   ADG+C  L  P  C
Sbjct: 186 MAY-----HGKVEHYRIEQTSGGQLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIIC 240

Query: 191 VLQKLGPLPGKDTPPPVTVP-------TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE 243
                            TV                    +   +    GE   +  G  +
Sbjct: 241 ETATFSSNGSSSFGSSSTVDLEDRTSVFRHAGLVIPSNEIDVGDTIGHGEFGDVRLGTYK 300

Query: 244 SLSSYISLAE 253
           +    + +++
Sbjct: 301 NRKVALKVSK 310


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  150 bits (379), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 45/146 (30%), Positives = 76/146 (52%), Gaps = 8/146 (5%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A+A   F A     LS R  + L I++ + D    ++E+ G+E  +PS Y+    H W
Sbjct: 1   MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            Y  ++R  AE+LL       GAFLIR S++  G +SLSV+       D ++H+++ R  
Sbjct: 61  YYGRITRADAEKLL--SNKHEGAFLIRISESSPGDFSLSVKC-----PDGVQHFKVLRDA 113

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
               ++   + F SL+ LVE++   +
Sbjct: 114 QSKFFLWV-VKFNSLNELVEYHRTAS 138



 Score = 55.1 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 21/89 (23%), Positives = 34/89 (38%), Gaps = 3/89 (3%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS 62
           SL+   +    +  S   D +   M PE  ++   AL  F   E   L  R G+ +T+  
Sbjct: 126 SLNELVEYHRTASVSRSQDVKLRDMIPE--EMLVQALYDFVPQESGELDFRRGDVITVTD 183

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
              + W    E+  R+   P+ YV     
Sbjct: 184 RSDENWW-NGEIGNRKGIFPATYVTPYHS 211


>UniRef50_UPI00017B0B45 UPI00017B0B45 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B0B45
          Length = 287

 Score =  149 bits (376), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 86/225 (38%), Positives = 127/225 (56%), Gaps = 30/225 (13%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
            +V  V L  +P+ E      R+GE L +++++   W V+S  + +E ++P+ +VAKV H
Sbjct: 61  PEVDLVVLQDYPSAEVCEPIYRMGEKLKLVAQEAYGWRVRSVQTRQENYIPASHVAKVYH 120

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           GWL+EG+ R+KAEELL LPGN  G+F++RES   RG YSLSV+         ++HYRI R
Sbjct: 121 GWLFEGVERQKAEELLSLPGNRVGSFMVRESTRERGSYSLSVKYRS------VKHYRIYR 174

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
           LDN W YISP LTF  L  ++ HY + ADG+                      PPV +  
Sbjct: 175 LDNSWYYISPSLTFQCLEDMINHYCDFADGL---------------------SPPVVMRR 213

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPL 256
           +    K   R L  +E   + + S+LS G+R S+++Y+S +E P 
Sbjct: 214 NFTWQKVNRRQLTSVE---NCDDSVLSYGVRNSIAAYLSFSEGPE 255


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  149 bits (376), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 48/145 (33%), Positives = 79/145 (54%), Gaps = 7/145 (4%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + +VAL SF A E   L+   G+ L I++ + D    ++E+ G E  +P  Y+    H W
Sbjct: 1   MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
               +SR+ AEE+L+   N  GAFLIRES++  G +S+SV        D+++H+++ R  
Sbjct: 61  YSGRISRQLAEEILMKR-NHLGAFLIRESESSPGEFSVSVNY-----GDQVQHFKVLREA 114

Query: 154 NGWLYISPRLTFPSLHALVEHYSEL 178
           +G  ++     F SL+ LV+ Y   
Sbjct: 115 SGKYFLWEEK-FNSLNELVDFYRTT 138



 Score = 54.4 bits (129), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 18/67 (26%), Positives = 27/67 (40%), Gaps = 3/67 (4%)

Query: 25  VSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHMPS 83
             +        A A   F A + ++LS R G+ + ++   D  WW  +S   GR    P 
Sbjct: 152 EPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSC--GRVGFFPR 209

Query: 84  VYVAKVA 90
            YV  V 
Sbjct: 210 SYVQPVH 216


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  147 bits (370), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 71/169 (42%), Gaps = 14/169 (8%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V   A  W +  ++R++AE LL       G FL+RES    G Y+L V         ++ 
Sbjct: 472 VKLNAMPWFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQS-----KVE 524

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HYR++ L+N  L I     F +L  LV HY   ADG+C  L + C+ +        ++  
Sbjct: 525 HYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-CLPKLGKQEFCINSKD 582

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                     W   +  L   E+   GE   +  G+  +    + + +D
Sbjct: 583 -----FVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKD 626


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  147 bits (370), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 71/169 (42%), Gaps = 14/169 (8%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V   A  W +  ++R++AE LL       G FL+RES    G Y+L V         ++ 
Sbjct: 677 VKLNAMPWFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQS-----KVE 729

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HYR++ L+N  L I     F +L  LV HY   ADG+C  L + C+ +        ++  
Sbjct: 730 HYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-CLPKLGKQEFCINSKD 787

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                     W   +  L   E+   GE   +  G+  +    + + +D
Sbjct: 788 -----FVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLKD 831


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  146 bits (368), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 47/146 (32%), Positives = 78/146 (53%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVA   F A  +  LS   G+ L I+S   +W+    E+  +E ++P  ++      W
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKA--ELGSQEGYVPKNFIDIQFPKW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
            +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR         ++H+++ R +
Sbjct: 59  FHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDD-----VQHFKVMRDN 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     FPSL+ LV++Y   +
Sbjct: 112 KGNYFLWTEK-FPSLNKLVDYYRTNS 136



 Score = 54.0 bits (128), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 20/71 (28%), Positives = 31/71 (43%), Gaps = 3/71 (4%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREYH 80
            +PV +Q       A AL  F A E   L    GE + ++ S +  WWT +  +  +   
Sbjct: 262 TDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGL 319

Query: 81  MPSVYVAKVAH 91
            P+ YVA +  
Sbjct: 320 FPANYVAPMTR 330


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score =  143 bits (360), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ L I+S + DW+    E++G+E ++P  Y+      W
Sbjct: 1   MEAQGKYDFMATGDTELSFRKGDILKILSPEDDWFKA--EMNGQEGYVPQNYIEIQTPRW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEELL   G   G F+IR  Q+  G +S+SVR         ++H+++ R  
Sbjct: 59  FQENASRSAAEELLRHKG--VGEFVIRGCQSSPGEFSISVRHESD-----VQHFKVMRDS 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     F SL+ LV+ Y   +
Sbjct: 112 RGQYFLWSEK-FTSLNKLVDFYRTSS 136



 Score = 62.1 bits (149), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 19/88 (21%), Positives = 30/88 (34%), Gaps = 7/88 (7%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPER------HKVTAVALGSFPAGEQARLSLRLGEPLTI 60
               SSP   +  P +   +M P +            AL  F A E   LS   G+ + +
Sbjct: 238 HTGRSSPVSGAQPPRRTCETMPPPQFLCVLQRADLVKALYDFTAEEDDELSFCAGDVIDV 297

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           +    + W       G     P+ Y A+
Sbjct: 298 LDRSDESWWKGRLR-GNSGLFPANYTAQ 324


>UniRef50_Q9N3S5 Putative uncharacterized protein n=4 Tax=Caenorhabditis
           RepID=Q9N3S5_CAEEL
          Length = 618

 Score =  142 bits (359), Expect = 8e-33,   Method: Composition-based stats.
 Identities = 54/276 (19%), Positives = 93/276 (33%), Gaps = 37/276 (13%)

Query: 2   GSLSSRG--KTSSPSPSSSGPDQEPVSMQ-----------PERHKVTAVALGSFPAGEQA 48
           G++S      ++   P+ +     PVS              E  +   +    F A    
Sbjct: 96  GNISRHPSATSTKSVPNGASFSPRPVSKTHSHHGSAKCSHSEPEEKMLIVENRFLAQTPK 155

Query: 49  RLSLRLGEPLTIISEDG-DWWTVQSEVSGREYHMPSVYVAK--VAHGWLYEGLSREKAEE 105
            +S+  G+ L +I +   +WW V S+    +  +P  +V        W    +S   AE+
Sbjct: 156 EMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSHVVYAEYREPWFAGNISSILAEQ 215

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLT- 164
            ++ P  P G+FLIRE  ++   + L VR S   S      YR +    G+         
Sbjct: 216 RVMQPQLPIGSFLIRE-NSKTDTFVLVVRSSHNESPQAYIIYR-RPNQEGFEIRDNHRPA 273

Query: 165 ---FPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWK 217
              F SLH LV HYS         IC  L +                P  T   +     
Sbjct: 274 VIHFGSLHQLVNHYSCEKVPGEIQICTKLTK-----------AAPPLPEQTEYMAMKKIH 322

Query: 218 KLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAE 253
                +  ++    G+   +     + +   +   +
Sbjct: 323 VNRSEVRRVKEIGRGQFGEVYLAKWKGVDVAVKSLK 358


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score =  142 bits (358), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 44/148 (29%), Positives = 74/148 (50%), Gaps = 10/148 (6%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           H + A+A   F A  +  LS + G+ L I+S   +W+    E+   E ++P  ++     
Sbjct: 14  HNMEAIAKFDFTASGEDELSFQAGDVLKILSSQEEWYKA--ELRSHEGYVPKNFIDFHVP 71

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W  E +SR +AE LL+  G   G F++R SQ   G +S+SVR         ++H+++ R
Sbjct: 72  HWFDEKISRHEAENLLMSKG--VGCFVVRASQNSHGDFSISVRHEDD-----VQHFKVMR 124

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELA 179
              G  Y+     F SL+ LV++Y   +
Sbjct: 125 DSKGSYYLWTEK-FHSLNKLVDYYKTSS 151



 Score = 54.4 bits (129), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 4/68 (5%)

Query: 22  QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQSEVSGREYH 80
            +P+  Q +R  +   AL  F A E   L  R G+ L ++ S +  WW  +  + G    
Sbjct: 244 TDPLHQQAQR-TLWVRALYDFDAMEHDELGFRSGDILEVLDSSNPSWWKGR--LRGELGL 300

Query: 81  MPSVYVAK 88
            P+ YV  
Sbjct: 301 FPANYVTP 308


>UniRef50_P42687 Tyrosine-protein kinase SPK-1 n=1 Tax=Girardia tigrina
           RepID=SPK1_DUGTI
          Length = 497

 Score =  141 bits (356), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 45/248 (18%), Positives = 86/248 (34%), Gaps = 28/248 (11%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYHM 81
              + +         A   + A     +S    E + ++ + D  W  V  +   +E  +
Sbjct: 25  PKKAYEGPPGSYMVKAKYKYAASGDTDISFEEKEIMYVLEQFDEFWLKVVKQKDNKEGLV 84

Query: 82  PSVYVAKVA------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
           PS YV+K          W    + R +AE+ L+  G   G ++IR S  +   Y+LSVR 
Sbjct: 85  PSNYVSKQDGSPQSVEAW--REIQRWEAEKSLMKIGLQKGTYIIRPS-RKENSYALSVRD 141

Query: 136 SRPASWDR-IRHYRIQ--RLDNGWLYISPRLTFPSLHALVEHYSELADGICC-PLREPCV 191
                    ++H++I+  + + G  Y      FP++  L++ Y +   G    PL +P  
Sbjct: 142 FDEKKKICIVKHFQIKTLQDEKGISYSVNIRNFPNILTLIQFYEKNGIGNTHIPLTDP-- 199

Query: 192 LQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR-ESLSSYIS 250
                       P     P    + +    ++  L     G    +       S      
Sbjct: 200 -----------MPDNYQPPVHFQDIEINRENIEILNEIGRGFFGSVHRAKWGRSYEVAAK 248

Query: 251 LAEDPLDD 258
           + +    +
Sbjct: 249 MLQSSKAE 256


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score =  141 bits (354), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ L I+S + DW+    E++G+E ++P  Y+      W
Sbjct: 1   MEAQGKYDFMATGDTELSFRKGDILKILSPEDDWFKA--EMNGQEGYVPQNYIEIQTPRW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEELL   G   G F+IR  Q+  G +S+SVR         ++H+++ R  
Sbjct: 59  FQENASRSAAEELLRHKG--VGEFVIRGCQSSPGEFSISVRHESD-----VQHFKVMRDS 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     F SL+ LV+ Y   +
Sbjct: 112 RGQYFLWSEK-FTSLNKLVDFYRTSS 136



 Score = 67.5 bits (163), Expect = 4e-10,   Method: Composition-based stats.
 Identities = 18/80 (22%), Positives = 28/80 (35%), Gaps = 1/80 (1%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
               SSP   +  P +   +M P +      AL  F A E   LS   G+ + ++    +
Sbjct: 205 HTGRSSPVSGAQPPRRTCETMPPPQRADLVKALYDFTAEEDDELSFCAGDVIDVLDRSDE 264

Query: 67  WWTVQSEVSGREYHMPSVYV 86
            W       G     P+ Y 
Sbjct: 265 SWWKGRLR-GNSGLFPANYT 283


>UniRef50_UPI000180C4D7 PREDICTED: similar to MGC115231 protein n=1 Tax=Ciona intestinalis
           RepID=UPI000180C4D7
          Length = 525

 Score =  139 bits (351), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 41/256 (16%), Positives = 86/256 (33%), Gaps = 35/256 (13%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISED 64
           +S     +P            +  P   ++    +  +P            E + I+++ 
Sbjct: 69  ASNMVGPTPLSQMRNLSLNQEANPPTTEELNYETIWGYPP-------FNRAESICILNKQ 121

Query: 65  GDWWTVQSEVSGREYHMPSVYV----AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
           GDWW  +S  +G+E  +PS YV    +     W +   S ++ E +L+      G ++I 
Sbjct: 122 GDWWKARSRETGQEGFIPSNYVALEDSIECERWFFGKKSEKECERMLVQQ--KPGTYMIT 179

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
           ES+T  G Y +S+ +    +   ++H  I    +                  +H+ +   
Sbjct: 180 ESKTEPGIYRISLTIQEALTL-LVKHQTIPLPHDRHH---------------KHHKQAFI 223

Query: 181 GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG 240
           G           Q+   +   +   P T   +  +W+     L   +   +G    + +G
Sbjct: 224 G-----NYIGRAQRGSIMKYGEHEKPETSGIAPGDWEIGREHLTQQKKLGAGAFGEVWKG 278

Query: 241 LRESLSSYISLAEDPL 256
                   I   +   
Sbjct: 279 GFHQ-DVAIKELQPCT 293


>UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59F39_HUMAN
          Length = 376

 Score =  137 bits (346), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 46/187 (24%), Positives = 89/187 (47%), Gaps = 15/187 (8%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISED 64
            ++  +  P P +   ++ P+    E  +   +AL  +   +   L+LR  E   ++   
Sbjct: 193 PTKNASKKPLPPTPEDNRRPL---WEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSS 249

Query: 65  GDWWTVQSEVSGREYHMPSVYVAKVAHG------WLYEGLSREKAEELLLLPGNPGGAFL 118
              W    + +G E ++PS Y+ + +        W  + +SR+KAE+LLL  G   GAF+
Sbjct: 250 EIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-GAFM 308

Query: 119 IRESQTRRGCYSLSVRLSRPASWD--RIRHYRIQRLDNG--WLYISPRLTFPSLHALVEH 174
           +R+S+T  G Y++SV      S +   I+HY I+  ++     Y++ +  F S+  L+ +
Sbjct: 309 VRDSRT-AGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINY 367

Query: 175 YSELADG 181
           +     G
Sbjct: 368 HQHNGGG 374


>UniRef50_B7Z4J2 cDNA FLJ50391, highly similar to SRC-like-adapter n=2 Tax=Homo
           sapiens RepID=B7Z4J2_HUMAN
          Length = 249

 Score =  137 bits (345), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 74/251 (29%), Positives = 115/251 (45%), Gaps = 53/251 (21%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           + +  +   S+  P + P+             L  +P+ + +    R GE L +IS++G 
Sbjct: 15  KKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGG 74

Query: 67  WWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
           WW   S  +GRE ++P + VA+V HGWL+EGL R+KAEELL LP    G+F+IRES+T+ 
Sbjct: 75  WWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETK- 133

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
                                                             E+ADG+CC L
Sbjct: 134 -------------------------------------------------KEVADGLCCVL 144

Query: 187 REPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDR---SLLFLEAPASGEASLLSEGLRE 243
             PC+ Q       + +  PVT+   +++W+++ R        E P   + SL S GLRE
Sbjct: 145 TTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRE 204

Query: 244 SLSSYISLAED 254
           S++SY+SL  +
Sbjct: 205 SIASYLSLTSE 215


>UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE
          Length = 249

 Score =  137 bits (345), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 44/184 (23%), Positives = 80/184 (43%), Gaps = 10/184 (5%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A     LS R G+ + I+  + DW+    E++G E  +P  Y+      W
Sbjct: 1   MEATGKYDFSATAGDELSFRKGDVIKILGTNDDWFRA--EINGMEGFVPRNYIVTTFPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR+ A++ L+    P GAF+IR SQ+  G +S+SVR         ++H+++ R  
Sbjct: 59  YKENTSRQSAQDELMCQ--PIGAFIIRGSQSSPGDFSISVRHEND-----VQHFKVMRDR 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS 213
            G  Y+   + F SL+ LV++Y+  +      +      +       +            
Sbjct: 112 QGRYYLWSEM-FTSLNKLVDYYTHNSISKQSRVFLLTDQRSSSDFLHRKPTEAPPFRQER 170

Query: 214 LNWK 217
            +++
Sbjct: 171 QDYR 174



 Score = 61.7 bits (148), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 16/82 (19%), Positives = 32/82 (39%), Gaps = 3/82 (3%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           R    S +P  + P Q  +   P+   +   A+  F A +   L+ + G+ + ++ +   
Sbjct: 170 RQDYRSLAPPVARPSQPSLP--PQVSALHVRAMYDFTAEDADELNFQAGDVIEVLDQSDR 227

Query: 67  WWTVQSEVSGREYHMPSVYVAK 88
            W  +  + GR    P  Y   
Sbjct: 228 SWW-KGVLRGRTGLFPVNYTNP 248


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score =  137 bits (344), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 30/168 (17%), Positives = 71/168 (42%), Gaps = 21/168 (12%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R++A++++       G FL+R + ++   Y+LS           ++HY I+  
Sbjct: 547 WYHADMTRQEADQVM--QNTNDGTFLVRNA-SKPKMYTLSFSFQ-----GVVKHYHIKTD 598

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
            +   Y+S R +F S+  L+E++   + G+   LR P       P+              
Sbjct: 599 SDNLFYVSQRHSFESVVQLIEYHKLNSAGLATRLRFPYTGTNNPPVL-----------LG 647

Query: 213 SLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS-SYISLAE-DPLDD 258
              ++     L  ++   +G+   + E L ++     + + + D + +
Sbjct: 648 YGVFQINRNELTIMKQIGTGQFGTVHEALWKNNKLVAVKMMKPDSMSE 695


>UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo salar
           RepID=B5X487_SALSA
          Length = 289

 Score =  137 bits (344), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F A  +  LS R G+ L I+    +W+    E+ G+E  +P  Y+ +    W
Sbjct: 1   MEARGKYEFNATAEDELSFRKGDILKILGSQDEWFKA--ELHGQEGFVPQNYIERQTPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEELL+      G FLIR SQ+  G +S+SVR         ++H+++ +  
Sbjct: 59  FKETASRSSAEELLM--SREVGGFLIRGSQSSPGEFSISVRHEFD-----VQHFKVMKDS 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
            G  ++     F SL+ LV+ Y   +
Sbjct: 112 KGHYFLWSEK-FTSLNKLVDFYKNTS 136



 Score = 54.7 bits (130), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 19/83 (22%), Positives = 34/83 (40%), Gaps = 4/83 (4%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVT-AVALGSFPAGEQARLSLRLGEPLTIISE-DG 65
              ++P  S   P +   +M  ++  V    A+ +F A E   L  R G+ + I+   D 
Sbjct: 208 PGRNTPLTSLQAPQRTSETMPHQQRAVIQVKAVYNFTAEEGDELGFRAGDVIDILDHSDP 267

Query: 66  DWWTVQSEVSGREYHMPSVYVAK 88
            WW  +  + G+    P+ Y   
Sbjct: 268 SWWKGR--LRGKSGLFPANYTTP 288


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  136 bits (343), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 43/230 (18%), Positives = 74/230 (32%), Gaps = 73/230 (31%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           + W +  +SR+  E LL       G+FL+R S++  G  S++VR        R+ HYRI 
Sbjct: 239 YSWYHGAVSRQAGEHLLR--SGITGSFLVRASESAPGQLSVTVR-----HLGRVYHYRIS 291

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL--------------REPCVLQKLG 196
           +   G  YI+    FP++  L+EH+S  ADG+ CPL              ++ C      
Sbjct: 292 QDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQSCYSSVPQ 351

Query: 197 PLPGKDTPPPVTV----------------------------------------------- 209
            LP    P P                                                  
Sbjct: 352 TLPSSRIPGPNQFEVNPIVHQSNAEISNFPLTHINPVSHVPRPFHPSHINNSERLSAYSD 411

Query: 210 ---PTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAED 254
                    W+     ++  +    G+   + E + +  +    +   + 
Sbjct: 412 SIGSMEFDGWEIDRPEIIMRQKLGCGQYGDVYEAVWKRFNSVVAVKTLKQ 461


>UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE
          Length = 284

 Score =  136 bits (343), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 10/146 (6%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + A     F    +  LS R G+ L I+    DW+    E+ G E ++P  YV +    W
Sbjct: 1   MEARGKYDFSGTAEDELSFRKGDTLKILGSQDDWFKA--ELHGHEGYVPKNYVDRQIPSW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLD 153
             E  SR  AEE L+      GAFLIR SQ+  G +S+SVR         ++H+++ +  
Sbjct: 59  FKESASRGSAEETLM--SREVGAFLIRGSQSSPGDFSISVRHDYD-----VQHFKVMKDK 111

Query: 154 NGWLYISPRLTFPSLHALVEHYSELA 179
           +G  Y+     F SL+ LV+ Y   +
Sbjct: 112 SGHYYLWTEK-FTSLNKLVDFYKTTS 136



 Score = 60.9 bits (146), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 17/88 (19%), Positives = 30/88 (34%), Gaps = 2/88 (2%)

Query: 2   GSLSSRGKT-SSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           GS+  +  T      +S  P +   +    R  +   A+  F A E   L    G+ + +
Sbjct: 197 GSVEEKSNTLGHQGKNSPAPRRTSETAPAPRSTIQVRAIYDFTAEEDDELGFNSGDIIEV 256

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           +      W       GR    P+ Y  +
Sbjct: 257 LDRSDASWWKGRLR-GRSGLFPANYTEQ 283


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  134 bits (336), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 51/232 (21%), Positives = 80/232 (34%), Gaps = 47/232 (20%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           G+++    ++         D        E      VAL SF +     LS   G+ L I+
Sbjct: 189 GNVAGWFPSNYTQEEGDADDTLHTYAMAENVLDIVVALYSFSSTNDQELSFEKGDRLEIL 248

Query: 62  SE---DGDWWTVQSEVSGREYHMPSVY------------------------------VAK 88
                D +W+  ++   G+   +P  Y                                 
Sbjct: 249 DRPPSDPEWYKARN-AQGQVGLVPRNYLQELSEYLTQPFLDRKQEPMERSQVAMGDKPHL 307

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
           V   W Y  ++R   + LL   G   G FLIR+S+T  G YS+S++     +  R +H+R
Sbjct: 308 VDKPWYYGSITRYMCDNLLNQRG-HDGDFLIRDSETNVGDYSVSLK-----APGRNKHFR 361

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSE-----LADGICCPLREPCVLQKL 195
           +     G LY   +  F +L  LV+HY          G    L  P      
Sbjct: 362 VHV--EGALYCIGQRKFHTLDQLVDHYQRAPIYTNKQGEKLYLVRPLPKPTT 411



 Score = 63.2 bits (152), Expect = 8e-09,   Method: Composition-based stats.
 Identities = 23/101 (22%), Positives = 37/101 (36%), Gaps = 10/101 (9%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQP---------ERHKVTAVALGSFPAGEQARLSLR 53
           S+    + S  S S+ G    P +M           +      VA   + A     L LR
Sbjct: 6   SVRGMPEPSWQSKSNFGAKSTPHAMAAPNIRHGKTGQDDICHVVAKYDYAAQGPQELDLR 65

Query: 54  LGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWL 94
             E   ++ +   WW VQ+  + +  ++PS YV K      
Sbjct: 66  KNERYLLLDDSKHWWKVQNSRN-QAGYVPSNYVKKEKPSLF 105



 Score = 57.4 bits (137), Expect = 5e-07,   Method: Composition-based stats.
 Identities = 21/90 (23%), Positives = 34/90 (37%), Gaps = 9/90 (10%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQ--------PERHKVTAVALGSFPAGEQARLSLRLGEPL 58
           +G  S   PS++ P +   S          P     TAV   ++ A +   LSL  G  +
Sbjct: 114 KGAGSKTLPSNNSPSRTVESPSMARRQAADPSEAIGTAVVKYNYQAQQPDELSLVKGSRI 173

Query: 59  TIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
            I+ +  D W  + +        PS Y  +
Sbjct: 174 LILEKSNDGWW-RGQSGNVAGWFPSNYTQE 202


>UniRef50_Q4T2Z8 Chromosome 18 SCAF10147, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4T2Z8_TETNG
          Length = 279

 Score =  133 bits (335), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 51/211 (24%), Positives = 88/211 (41%), Gaps = 33/211 (15%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVAL SFPA E   L+ + G+ + +   + D     +E+ G+  ++P  Y++ + + W
Sbjct: 1   MEAVALFSFPAAEADELTFQEGDVIKVTEMEDDSGWFTAEIQGKRGYIPQNYISLLPYPW 60

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS------------- 140
               +SR +AE+ L       G FL+RES++  G +S+SV                    
Sbjct: 61  FVGRVSRLEAEKRLRWQD--PGVFLVRESESAPGEFSVSVSFVFNWHKTNLSLSSGGHSS 118

Query: 141 --------------WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI--CC 184
                          +R+ H+R+   + G  Y     +F SL+ LV+ Y   +  +    
Sbjct: 119 DLRAWVLPHDIVSYGNRVEHFRVL--EGGGQYCIWEESFCSLNRLVDFYRTHSIAMDKVV 176

Query: 185 PLREPCVLQKLGPLPGKDTPPPVTVPTSSLN 215
            LR+P    +  P       P  T    SL+
Sbjct: 177 CLRDPPSSPQRQPGCNPYPNPYKTCSRESLH 207


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score =  133 bits (335), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 40/218 (18%), Positives = 79/218 (36%), Gaps = 20/218 (9%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISEDGD-WWTVQSEVSGREYH 80
                +P   K   VA+  +    +   LS + G+   + ++ GD W  V +  +G +  
Sbjct: 173 PVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGM 232

Query: 81  MPSVYV--------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           +    V              W +   ++ +A ++L+  G   G+FL+R S    G YSL 
Sbjct: 233 IFRELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAG--PGSFLVRPSDNSPGDYSLF 290

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
             +      ++I+ +RI++   G  Y+    TF  L A++  Y +        L  P V 
Sbjct: 291 FHI-----NNQIQRFRIEK--KGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVV- 342

Query: 193 QKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
             + P   +               ++    +   +   
Sbjct: 343 NGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKG 380



 Score = 92.1 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 33/152 (21%), Positives = 53/152 (34%), Gaps = 11/152 (7%)

Query: 79  YHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRP 138
              P++ +A     W +  L R  AE  L       G++L+RES  + G Y LS      
Sbjct: 71  GERPAI-IAPPESEWYHGRLDRYSAESRLRGSSK-LGSYLVRESDRKPGSYVLSY----- 123

Query: 139 ASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC-CPLREPCVLQKLGP 197
                I H+RI  +   +        F SL  LV +Y+  +D +    L  P    +   
Sbjct: 124 YGRTGINHFRITAVCGDFYI--GGRQFISLSDLVGYYTSCSDLLKRERLAIPVAPPEPVN 181

Query: 198 LPGKDTPP-PVTVPTSSLNWKKLDRSLLFLEA 228
              +     P T    +         + F+  
Sbjct: 182 DKKRVVAILPYTKMPETDELSFQKGDIFFVHN 213


>UniRef50_UPI00004D86FC Tyrosine-protein kinase Tec (EC 2.7.10.2). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI00004D86FC
          Length = 647

 Score =  133 bits (334), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 32/154 (20%), Positives = 62/154 (40%), Gaps = 12/154 (7%)

Query: 105 ELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW-DRIRHYRIQRLDN-GWLYISPR 162
           ++ +L  +  G F++R S ++ G Y++S+           IRHY I+        Y++ +
Sbjct: 301 QMQMLQIDKEGGFIVRNS-SQAGLYTVSLYTKYGGEGSTCIRHYHIKETQYPKKYYLAEK 359

Query: 163 LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
             F ++  ++E++   A G+   LR P   +        +   P T   S   W+     
Sbjct: 360 HVFNTIPEMIEYHKHNAAGLVTRLRYPVCSK--------NKSAPTTAGFSYDKWEINPSE 411

Query: 223 LLFLEAPASGEASLLSEG-LRESLSSYISLAEDP 255
           L F++   SG   ++  G  R      I    + 
Sbjct: 412 LTFMKELGSGLFGVVRLGKWRAQYKVAIKAIREG 445


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score =  133 bits (334), Expect = 7e-30,   Method: Composition-based stats.
 Identities = 48/172 (27%), Positives = 76/172 (44%), Gaps = 18/172 (10%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + AVA   F   E   L    G  L I+   ED +W+  +  +  +E  +P+ Y++   H
Sbjct: 1   MEAVANYPFTPTEPDELGFEKGSTLYIVGMEEDPNWYKAR--LGNQEGMVPANYISLYPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AE  LL           P GAF++R+S+   G +S+SV+         +
Sbjct: 59  PWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVK-----EGSSV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD-GICCPLREPCVLQKL 195
            H+RI     G  YI     F S++AL++++      G+   L   CV  K 
Sbjct: 114 LHFRIFFDPKGKYYIWT-NKFDSINALIDYHRHQTIYGVKALLLRDCVSSKT 164



 Score = 57.1 bits (136), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 7/81 (8%)

Query: 14  SPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTVQ- 71
            P+    D  P  +         VA   F A  Q  +S R G+ L ++  ED +WW  + 
Sbjct: 205 HPAQMNLDLPPGVVFTNLSGRQCVAKFDFNAEFQEEMSFRQGDRLRLLGEEDENWWFAEL 264

Query: 72  --SEVSGR---EYHMPSVYVA 87
                SG+   +  +P+ YV 
Sbjct: 265 ITHASSGQPTPQGLIPANYVK 285


>UniRef50_UPI00016E6CB5 UPI00016E6CB5 related cluster n=4 Tax=Takifugu rubripes
            RepID=UPI00016E6CB5
          Length = 1546

 Score =  131 bits (330), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 48/224 (21%), Positives = 80/224 (35%), Gaps = 19/224 (8%)

Query: 1    MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
            MG  ++    S+P      P      + P+  +   ++ G     +   L   +G     
Sbjct: 1184 MGRRTAMSGHSTPDDIGPPPSTPAFPVSPQLPEKRHMSTGDVERTDNKNLMAGVGSSAPN 1243

Query: 61   ISEDGDWWTVQSEVSG---REYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAF 117
            +S       VQ  +      +  M   +V   +  W    +SRE+A  LL       GAF
Sbjct: 1244 LSGTHTLTDVQKSIYADGYPDIKMNVKFVQDTSKFWYKPDISREQAINLL--KDREPGAF 1301

Query: 118  LIRESQTRRGCYSLSVRLSRPA------------SWDRIRHYRIQRLDNGWLYIS--PRL 163
            +IR+S + RG Y L+++++ P             + + +RH+ I+    G          
Sbjct: 1302 IIRDSHSFRGAYGLAMKVACPPPTVQQNKKVGDLTNELVRHFLIETSSRGVRLKGCPNEP 1361

Query: 164  TFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
             F  L ALV  +S     + C L  P        L       PV
Sbjct: 1362 YFGCLSALVYQHSMTPLALPCKLMIPTKDPNEEALELATPTDPV 1405


>UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicum
           RepID=Q5DBN4_SCHJA
          Length = 312

 Score =  131 bits (329), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 48/172 (27%), Positives = 78/172 (45%), Gaps = 18/172 (10%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A+A  +F   E   L    G  L I+   ED +W+  +     +E  +P+ Y++   H
Sbjct: 1   MEAIANYAFSPTEPDELGFEKGSTLCIVGMEEDPNWYKAR--QGNQEGMVPANYISLCPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AE  LL           P GAF++R+S+   G +S+SV+         +
Sbjct: 59  PWYIPKCSRREAEARLLETDPNTHRDVQPDGAFVLRQSENDPGHFSISVK-----EGSSV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD-GICCPLREPCVLQKL 195
            H+RI    +G  YI     F S++AL++++      GI   L   CV  K+
Sbjct: 114 LHFRIFFDPSGKYYIWT-NKFSSINALIDYHRHQTIYGIKALLLRDCVSSKI 164



 Score = 53.2 bits (126), Expect = 8e-06,   Method: Composition-based stats.
 Identities = 18/97 (18%), Positives = 31/97 (31%), Gaps = 14/97 (14%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMP 82
            P  M         VA   F A  +  +S R G+ L ++ E+ + W     ++      P
Sbjct: 213 PPGVMCTNLSGRHCVAKFDFDAEFREEMSFRRGDRLRLLGEEDENWWFAELLTHAPGSQP 272

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
           S           +  +     E L     N    F++
Sbjct: 273 SS----------HGLIPANYVELL----SNSTPDFMV 295


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  130 bits (326), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 33/186 (17%), Positives = 70/186 (37%), Gaps = 17/186 (9%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISE-DGDWWTVQSEVSGREYH 80
                +P   +    A+  +        +S   G+   + +E +  W  V +  +  +  
Sbjct: 271 PVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGL 330

Query: 81  MPSVYV--------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           +    V              W +  +S+++A  LL+  G    +FL+R S    G YSL 
Sbjct: 331 IVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLY 389

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
            R     + + I+ ++I    N   ++     + S+  +++HY +        L+EP  +
Sbjct: 390 FR-----TNENIQRFKICPTPNNQ-FMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPM 443

Query: 193 QKLGPL 198
           Q    +
Sbjct: 444 QDQEQV 449



 Score = 99.4 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 34/152 (22%), Positives = 53/152 (34%), Gaps = 16/152 (10%)

Query: 84  VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
              A   + W +  L R  AEE L   G   G++LIRES  R G + LS         + 
Sbjct: 172 PLTAPPTNQWYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLSQ----MNV 226

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC-CPLREPCVLQKL------- 195
           + H+RI  +   +        F SL  L+ +YS ++  +    L  P    +        
Sbjct: 227 VNHFRIIAMCGDYYI--GGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRV 284

Query: 196 -GPLPGKDTPPPVTVPTSSLNWKKLDRSLLFL 226
              LP    P    +     +   +   L   
Sbjct: 285 RAILPYTKVPDTDEISFLKGDMFIVHNELEDG 316


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score =  130 bits (326), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 47/137 (34%), Positives = 67/137 (48%), Gaps = 14/137 (10%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPS 83
               E      VAL  F AG + +LSL+ GE + I+  ++ G+W    S+ SG    +PS
Sbjct: 182 PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD-SGNVGWVPS 240

Query: 84  VYVAK----VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            YV        H W +  +SR  AE LL    N  G+FL+RES++  G  S+S+R     
Sbjct: 241 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE--- 295

Query: 140 SWDRIRHYRIQRLDNGW 156
              R+ HYRI    +G 
Sbjct: 296 --GRVYHYRISEDPDGK 310


>UniRef50_Q4SM94 Chromosome 3 SCAF14553, whole genome shotgun sequence n=1
            Tax=Tetraodon nigroviridis RepID=Q4SM94_TETNG
          Length = 1679

 Score =  129 bits (324), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 45/223 (20%), Positives = 76/223 (34%), Gaps = 18/223 (8%)

Query: 1    MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
            MG  ++    S+P      P      + P+  +   ++ G     +   L    G     
Sbjct: 1296 MGRRTAMSGRSTPDDIGPQPLTPAFPVSPQLPEKRHMSTGDVERTDNKNLMAGGGSSAPN 1355

Query: 61   ISEDGDWWTVQSEVSGREYHMPSV--YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
            +S       V   +      +     +V   +  W    +SRE+A  LL       GAF+
Sbjct: 1356 LSGTHTSTDVPKSIYDGYPDIKMNVKFVQDTSKFWYKPDISREQAINLL--KDREPGAFI 1413

Query: 119  IRESQTRRGCYSLSVRLSRPA------------SWDRIRHYRIQRLDNGWLYIS--PRLT 164
            IR+S + RG Y L+++++ P             + + +RH+ I+    G           
Sbjct: 1414 IRDSHSFRGAYGLAMKVACPPPTVPQNKKVGDLTNELVRHFLIETSAKGVRLKGCPNEPY 1473

Query: 165  FPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
            F  L ALV  +S     + C L  P        L        V
Sbjct: 1474 FGCLSALVYQHSMTPLALPCKLMIPTKDPNEEALELATPTDSV 1516


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  129 bits (323), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 55/213 (25%), Positives = 82/213 (38%), Gaps = 21/213 (9%)

Query: 20  PDQEPVSMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISE-DGDWWTVQSEVSGR 77
                   +P   K   VA   +        LS   GE   + +E  G W  V S+ SG 
Sbjct: 154 LQYPAPPPEPVDDKKKVVATLPYNKVPDTDELSFSAGEVFVVHNELGGGWLWVTSQRSGE 213

Query: 78  EYHMPSVYVAKVA--------HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
              +    V  V           W +  +S+E+A E L   G+ GG FLIR S    G Y
Sbjct: 214 SGIIVQDLVKPVEGEIDPNEGKVWFHGNVSKEEAAETLWKDGDIGG-FLIRNSDKNPGDY 272

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           SLS R       + I+ +RIQ+      Y+     + SL A+V+HY +        LR+P
Sbjct: 273 SLSFR-----GPNTIQRFRIQKQQR--QYVMGGRYYNSLDAIVDHYKKEEIIDGFKLRDP 325

Query: 190 CVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
              +K      + T    + P +    ++   S
Sbjct: 326 TAPKKFK---NQTTSTEDSSPMNYEELRRRRSS 355



 Score = 89.4 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 38/182 (20%), Positives = 75/182 (41%), Gaps = 21/182 (11%)

Query: 81  MPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
           + +   A   + W +  L R+ AE  L     P G++L+RES+ + G Y LS    R   
Sbjct: 56  VDANLTAPPENEWYHGCLDRQSAELRLNAADKP-GSYLVRESERKPGSYVLSYLGQR--- 111

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC-CPLREPCV-------- 191
              I H+R+  +   +        F +L  L+ +Y+ +++ +    L+ P          
Sbjct: 112 --GINHFRVTAVCGDFY--VGGRQFQTLPELIGYYTHISNILKNERLQYPAPPPEPVDDK 167

Query: 192 LQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSL----LFLEAPASGEASLLSEGLRESLSS 247
            + +  LP    P    +  S+     +   L    L++ +  SGE+ ++ + L + +  
Sbjct: 168 KKVVATLPYNKVPDTDELSFSAGEVFVVHNELGGGWLWVTSQRSGESGIIVQDLVKPVEG 227

Query: 248 YI 249
            I
Sbjct: 228 EI 229


>UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n=3 Tax=Schistosoma
           RepID=C1LZF7_SCHMA
          Length = 234

 Score =  128 bits (321), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 50/215 (23%), Positives = 85/215 (39%), Gaps = 30/215 (13%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           + A A   F A  +  L  + G  L I+   +D +W+  + E  GR   +P  Y+    H
Sbjct: 1   MEAEASYDFVANAEDELGFKKGSLLKILCVEDDPNWYLAEQE--GRTGLIPCNYITMRPH 58

Query: 92  GWLYEGLSREKAEELLLLPG-------NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            W     SR +AEE L            P GAF++R+S+     +SLSV+         +
Sbjct: 59  PWYIRHCSRMEAEERLQEIDQETAQHLQPDGAFILRQSEADGKGFSLSVK-----QGCEV 113

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
            H+++ + + G  +      F S++ L++H+ + +      L               D  
Sbjct: 114 LHFKVLQDEAGKYFFWLSK-FDSINQLIDHHRKTSISRNRLLTL------------VDLV 160

Query: 205 PPVTVPTSSLNWKKLDRSLLF-LEAPASGEASLLS 238
           P    PT+   ++       F  E   +GE SL  
Sbjct: 161 PSKRFPTNVRKYQLDRVIARFDFETKGAGELSLHR 195



 Score = 58.2 bits (139), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 15/69 (21%), Positives = 25/69 (36%)

Query: 20  PDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREY 79
           P +   +   +      +A   F       LSL  G+ + +IS + + W       GR  
Sbjct: 161 PSKRFPTNVRKYQLDRVIARFDFETKGAGELSLHRGDVIEVISRNDENWWRGRTSDGRCG 220

Query: 80  HMPSVYVAK 88
             PS +V  
Sbjct: 221 LFPSNFVDD 229


>UniRef50_UPI0001A2C9CC UPI0001A2C9CC related cluster n=1 Tax=Danio rerio
           RepID=UPI0001A2C9CC
          Length = 388

 Score =  127 bits (320), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 13/161 (8%)

Query: 93  WLYEGL-SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +E + +R +A+  LL P N  GAFL+ +       Y LS ++ +  +    RHYRI++
Sbjct: 1   WYFENVKTRVEAKRCLLRPENKEGAFLVWKCDEN-NHYYLSGKVHKVKNGPHARHYRIKQ 59

Query: 152 LD-NGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
            + +   ++    TF SL  L+E YS+   G+C  L E CV          D P P T+ 
Sbjct: 60  GENDQQFFLVHHTTFQSLRKLIEFYSKHEGGLCAKLHEACVK--------LDQPVPQTLS 111

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES-LSSYIS 250
             S   +    SL   +   SGE + + +GL  +     I 
Sbjct: 112 FDSKC-EIDRSSLTKQQKLGSGEFADVWQGLWNNTTEVAIK 151


>UniRef50_UPI00017B38C7 UPI00017B38C7 related cluster n=1 Tax=Tetraodon nigroviridis
            RepID=UPI00017B38C7
          Length = 1373

 Score =  126 bits (317), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 45/224 (20%), Positives = 78/224 (34%), Gaps = 21/224 (9%)

Query: 1    MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
            MG  ++    S+P      P      + P+  +   ++ G     +   L    G     
Sbjct: 1011 MGRRTAMSGRSTPDDIGPQPLTPAFPVSPQLPEKRHMSTGDVERTDNKNLMAGGGSSAPN 1070

Query: 61   ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIR 120
            +S       V   +   + ++   +V   +  W    +SRE+A  LL       GAF+IR
Sbjct: 1071 LSGTHTSTDVPKSIYDIKMNV--KFVQDTSKFWYKPDISREQAINLL--KDREPGAFIIR 1126

Query: 121  ESQTRRGCYSLSVRLSRPA------------SWDRIRHYRIQRLDNGWLYIS--PRLTF- 165
            +S + RG Y L+++++ P             + + +RH+ I+    G           F 
Sbjct: 1127 DSHSFRGAYGLAMKVACPPPTVPQNKKVGDLTNELVRHFLIETSAKGVRLKGCPNEPYFG 1186

Query: 166  --PSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
                L ALV  +S     + C L  P        L        V
Sbjct: 1187 VVGCLSALVYQHSMTPLALPCKLMIPTKDPNEEALELATPTDSV 1230


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  125 bits (314), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 34/170 (20%), Positives = 62/170 (36%), Gaps = 29/170 (17%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  + R ++  LL       G FL+RES    G + LS +     +  ++RH+++Q
Sbjct: 468 QTWFHGTIPRTESLRLLQQ----DGDFLLRESNNSLGDFVLSAK-----ADGQVRHFKVQ 518

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             DNG         FP++  L+ H+ +         REP   +    L           P
Sbjct: 519 VTDNGMYRFEADQ-FPTVLNLISHHYQK--------REPVTKRTNCLL---------LNP 560

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGL--RESLSSYISLAEDPLDD 258
                W+              G    + + L  RE+    +   ++ +D+
Sbjct: 561 ICKDKWQLSHDDFTIDCKIGQGNFGEVYKALFIRENYYVAVKTCKETVDN 610


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  125 bits (314), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 37/178 (20%), Positives = 65/178 (36%), Gaps = 13/178 (7%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           +      W +  +SRE++E+ +   G   G FL+RE  T    ++L V +        I 
Sbjct: 156 ILHRKQLWFHGAISREESEQRMKAFGLRDGLFLVRER-TEVNSFALCVAVKND-----IY 209

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HY ++    G L I     F +L  +V+HYS   DG+ C L + C + +         P 
Sbjct: 210 HYLLEMNTLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVP-MPG 268

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS------SYISLAEDPLD 257
            V         +  D  L       +G    +  G+    +        +   +   +
Sbjct: 269 AVVKRVKHGPRRIEDSELSTQGELGAGTFGTVRLGVYRPKNGEPEVQCALKYLKQSEE 326



 Score =  116 bits (290), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 5/119 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +SR  AE+LL   G   G+FL+R+S T  G Y LS+            HY I R 
Sbjct: 9   WYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKK-----YHYIISRH 63

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
            +G + I     F S   L++++++  DG+   L++PC      P  G        +  
Sbjct: 64  PDGSVAIQDGAKFDSPIELIQYHTKKVDGLITTLKQPCCRLPGQPPQGYRFISHEEMQM 122


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  125 bits (313), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 39/189 (20%), Positives = 68/189 (35%), Gaps = 17/189 (8%)

Query: 73  EVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           EV        S   +     W +  L R +A  +L       G FL+R    R+  Y LS
Sbjct: 270 EVEQMLNEFVSPMPSSRKDQWYHGKLDRHEATAILKTKD-VDGCFLVRM--NRQSGYVLS 326

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
           +  +     ++  H++IQ   + + +I       SL  L++HY+   DG+   L  P   
Sbjct: 327 MMCT-----NQCYHFQIQ-DRDKYYFIDNGPYLNSLEHLIQHYTLFPDGLPNKLEVPVSP 380

Query: 193 QKLGPLPGKDT---PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESL---- 245
             + PLP         P     +      +  +L+  E    GE   + +G  ++     
Sbjct: 381 AVIPPLPKGFPFTLKKPKPKHQTEFQDNIMRDNLILDEVIGEGEFGSVYKGTFQNRDGFE 440

Query: 246 -SSYISLAE 253
               I +  
Sbjct: 441 EKVAIKMLR 449



 Score =  109 bits (273), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 41/177 (23%), Positives = 72/177 (40%), Gaps = 23/177 (12%)

Query: 84  VYVAKVAHGWLYEGLSREKAEELLL-LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
            +   V   W +  +SR+ AE +LL       G FL+RES +  G Y L V        +
Sbjct: 3   NHSENVDINWYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVL-----QNN 57

Query: 143 RIRHYRIQRL-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
            + HY+I+R  ++ +  I  +     L  L+EHY        C + +P +  +L     K
Sbjct: 58  EVVHYQIRRHGEDAFFSIDEQNIMHGLETLIEHY--------CKVNDPSLGVQLSKPIVK 109

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
           D PP  T        ++  R+ L   A       +++E L+    +  +  ++    
Sbjct: 110 DPPPHDT--------RRHGRTNLLHRAITQANCKVVTELLKCGYRNLEAKNQEGQTA 158


>UniRef50_B4DP99 cDNA FLJ51496, highly similar to Tyrosine-protein kinase CSK (EC
           2.7.10.2) n=6 Tax=Euteleostomi RepID=B4DP99_HUMAN
          Length = 399

 Score =  124 bits (312), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 44/230 (19%), Positives = 73/230 (31%), Gaps = 61/230 (26%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII--SEDGDWWTVQSEVSGREYHMPSV 84
                     +A  +F    +  L    G+ LTI+  ++D +W+  +++V GRE  +P+ 
Sbjct: 5   QAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPAN 63

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
           YV                        G   G               LS+           
Sbjct: 64  YVQ--------------------KREGVKAGT-------------KLSLMPW-------- 82

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
            H        G L I   + F +L  LVEHY+  ADG+C  L +P V++       +   
Sbjct: 83  FH--------GKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDE--- 131

Query: 205 PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
                      W    + L  L+    GE   +  G        +   ++
Sbjct: 132 ------FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKN 175


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  124 bits (312), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 36/165 (21%), Positives = 64/165 (38%), Gaps = 28/165 (16%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  + R +A+ELL       G FL+RES  + G Y LSV      S  + RH+ IQ
Sbjct: 458 QDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSV-----YSDGQRRHFIIQ 508

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
            +DN + +      F ++  L++H+               + +K G +     P      
Sbjct: 509 YVDNMYRFEGTG--FSNIPQLIDHHYTTKQ---------VITKKSGVVLLNPIP------ 551

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAED 254
                W      ++  E    G    + +G L++  S  +   ++
Sbjct: 552 -KDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKE 595


>UniRef50_UPI0000E1F79D PREDICTED: growth factor receptor-bound protein 14 isoform 1 n=1
           Tax=Pan troglodytes RepID=UPI0000E1F79D
          Length = 491

 Score =  123 bits (309), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 40/177 (22%), Positives = 76/177 (42%), Gaps = 17/177 (9%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHM---- 81
                  + + VA+  F +G+++R+     E L++  E+G  W   +   G         
Sbjct: 319 PPVRSISENSLVAM-DF-SGQKSRVIENPTEALSVAVEEGLAWRSSATNMGIHLKQSFAF 376

Query: 82  --PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
             P       +  W +  +SR++A+ L++  G   G FL+R+SQ+    + LS+     +
Sbjct: 377 IHPISLAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSM-----S 431

Query: 140 SWDRIRHYRIQRL-DNGWLY---ISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
              +I+H++I  + D+G ++         F  L  LVE Y      + C L+  C  
Sbjct: 432 HGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 488


>UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=Euteleostomi
           RepID=Q5SUW3_MOUSE
          Length = 550

 Score =  123 bits (309), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 17/191 (8%)

Query: 15  PSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEV 74
           P   G      +      + + VA+  F +G+  R+     E  +   E+G  W  +S  
Sbjct: 367 PQRKGLPPPFNAPMRSVSENSLVAM-DF-SGQIGRVIDNPAEAQSAALEEGHAWRKRSTR 424

Query: 75  ----SGREYHMPS--VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC 128
               S +    PS    V      W +  +SRE++  ++   G   G FL+R+SQ+    
Sbjct: 425 MNILSSQSPLHPSTLNAVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKA 484

Query: 129 YSLSVRLSRPASWDRIRHYRI-QRLDNGWLYI---SPRLTFPSLHALVEHYSELADGICC 184
           + L++         +I++++I    D+G  +         F  L  LV+ Y      + C
Sbjct: 485 FVLTL-----CHHQKIKNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPC 539

Query: 185 PLREPCVLQKL 195
            L+  C+   L
Sbjct: 540 KLKHHCIRVAL 550


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score =  123 bits (309), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 46/189 (24%), Positives = 86/189 (45%), Gaps = 15/189 (7%)

Query: 34  VTAVALGSFPAG--EQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVA-KVA 90
           +  VAL  F     EQ  L+ + GE L +I  +   W +  +   ++  +P  Y+  + +
Sbjct: 1   MEYVALFDFSPSKEEQDELAFKKGEVLKVIKREDRHWLLAHQG-AKQGLVPENYLKIEKS 59

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR--GCYSLSVRLSRPASWDRIRHYR 148
           H W    +SR+ AEE L+      GAF+IR+S++    G +SLSV+       D+++H++
Sbjct: 60  HPWYVGKISRKVAEEYLMSMP-SDGAFMIRDSESNPDSGNFSLSVKFR-----DQVQHFK 113

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADG--ICCPLREPCVLQKLGPLPGKDTPPP 206
           I     G  ++   + F S++ LV+++ + +        L EPCV  +      +     
Sbjct: 114 ILTDLAGKYFLWV-VKFTSINDLVDYHKDNSVSRTQEIVLNEPCVPIEDANQRPQPAMQQ 172

Query: 207 VTVPTSSLN 215
                  + 
Sbjct: 173 SRERLQQVK 181



 Score = 48.6 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 16/82 (19%), Positives = 31/82 (37%), Gaps = 4/82 (4%)

Query: 15  PSSSGPDQEPVSMQPERHK-VTAVALGSFPAGEQARLSLRLGEPLTII-SEDGDWWTV-- 70
           P      +   +MQ  R +     AL +F + +   L+ +  + +T+      DWW    
Sbjct: 158 PIEDANQRPQPAMQQSRERLQQVKALYNFESDDAQELTFKQNDVITLTGRPHADWWEGEI 217

Query: 71  QSEVSGREYHMPSVYVAKVAHG 92
           ++    R    P  YV ++   
Sbjct: 218 RAPTGTRRGIFPKNYVKELDPH 239


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score =  122 bits (306), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 39/218 (17%), Positives = 78/218 (35%), Gaps = 21/218 (9%)

Query: 23  EPVSMQPERHKVTAVALGSFPAGEQ-ARLSLRLGEPLTIISEDGD-WWTVQSEVSGREYH 80
                +P   K   VA+  +        LS + G+   + ++ GD W  V +  +G +  
Sbjct: 166 PTPPPEPVNDKKRIVAILPYTKMPDTDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGL 225

Query: 81  MPSVYV--------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           +    V              W +  +++ +A ++L+  G   G+FL+R S    G YSL 
Sbjct: 226 IFRELVDDLDDSIDPNTVFSWFHPNVTKSEAVDMLVKAG--PGSFLVRPSDNSPGDYSLF 283

Query: 133 VRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
             +      ++I+ +RI++   G  Y+    TF  L A++  Y +        L +  V 
Sbjct: 284 FHI-----NNQIQRFRIEK--KGVRYLMGGRTFECLDAVINRYRKEQIVEGHTLVQAMVT 336

Query: 193 QKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPA 230
           +  G +                  ++        +   
Sbjct: 337 EPDGTVRVNKEVQHAE--KIYATLRECREQSGAKKNKG 372



 Score = 97.5 bits (241), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 33/148 (22%), Positives = 53/148 (35%), Gaps = 10/148 (6%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           + + A   + W +  L R  AEE L       G++L+RES  + G Y LS          
Sbjct: 67  TTFSAPPENQWYHGRLDRFTAEERLRDASR-LGSYLVRESDRKPGSYVLSYL-----GRT 120

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI-CCPLREPCVLQKLGPLPGK 201
            I H+RI  +   +        F SL  LV +Y+  +D +    L  P    +      +
Sbjct: 121 GINHFRITAVCGDYYI--GGRQFNSLMDLVAYYTHCSDLLKKERLIHPTPPPEPVNDKKR 178

Query: 202 DTPP-PVTVPTSSLNWKKLDRSLLFLEA 228
                P T    +         + F+  
Sbjct: 179 IVAILPYTKMPDTDELSFQKGDIFFVHN 206


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score =  122 bits (306), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 39/197 (19%), Positives = 74/197 (37%), Gaps = 18/197 (9%)

Query: 10  TSSPSPSSSGPDQEPVS-MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWW 68
            S   P        P S       + + VA+  F      R+     E  +   E+G  W
Sbjct: 419 QSYNVPQQRKSSLPPFSAPVRSVSENSLVAM-DFSGRT-GRIIDNPVEAQSAALEEGQTW 476

Query: 69  TVQSEVSGREYHMPSVYVA------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
             +S+          ++ +           W +  + RE+A ++++  G   G FL+R+S
Sbjct: 477 RKRSQRMNVLGSPSPMHPSSLSAAIHRTQVWFHGRIVREEAHKMIIQQGQVDGLFLLRDS 536

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRI-QRLDNGWLYI---SPRLTFPSLHALVEHYSEL 178
           Q+    + L++         +I+H++I    ++G ++         F  L  LV+ Y   
Sbjct: 537 QSNPRAFVLTL-----CHHQKIKHFQILPCEEDGQVFFSLDDGSTKFTDLIHLVDFYQLN 591

Query: 179 ADGICCPLREPCVLQKL 195
              + C L+ PC    L
Sbjct: 592 RGVLPCKLKHPCTAVAL 608


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score =  122 bits (305), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 40/223 (17%), Positives = 67/223 (30%), Gaps = 58/223 (26%)

Query: 84  VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
                  + +L++ + R  A E L   G   G+FLIR +  + G Y+L++   +      
Sbjct: 283 PKPRMNTNDFLHKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTP---- 338

Query: 144 IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
             HY +    + W +I     F +L A+V+HY+  ADG+   L  P        +P    
Sbjct: 339 -YHYEVVCESDCWYFIDDGPLFDTLPAVVDHYTIFADGLPTTLLYPVPPSGRKNVPFSSP 397

Query: 204 PPP----------------------VTVPTSSLNWK------------------------ 217
           P P                       TVP                               
Sbjct: 398 PQPGALLFAQGLKNLPKHLQAHLTASTVPRMRDQPPFPVAALAPPPPPIQILAREKGPQL 457

Query: 218 --KLDRSLLFLEAPASGEASLLSEGLRES-----LSSYISLAE 253
               +  L        GE   + +GL +      +   +    
Sbjct: 458 SYISEHDLHLGAELGQGEFGSVLKGLYKGADGKKIEVAVKTLR 500



 Score =  104 bits (259), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 37/181 (20%), Positives = 61/181 (33%), Gaps = 21/181 (11%)

Query: 91  HGWLYEGLSREKAEELLLLPG--NPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
             W +  ++RE A  L+         G FL+RES    G Y L++          ++ ++
Sbjct: 8   ERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGN-----VQQFQ 62

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I     GW  +     F  L  L+ HY    DG+   L +  +     P P        T
Sbjct: 63  IMGHGEGWFSVDNGPLFQGLDELIHHYQLKPDGLPVQLNDYVI---GNPPPPGARKRTET 119

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASL-----------LSEGLRESLSSYISLAEDPLD 257
               ++  + L   L  L  PAS                + E  +   +  +S+      
Sbjct: 120 ELHKAVATRDLAAVLSILSQPASSNLGTVDAQNIEGTTPVHEAAKRGYNDVLSVLLQXRP 179

Query: 258 D 258
           D
Sbjct: 180 D 180


>UniRef50_C4PYF4 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYF4_SCHMA
          Length = 855

 Score =  122 bits (305), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 33/136 (24%), Positives = 69/136 (50%), Gaps = 7/136 (5%)

Query: 24  PVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPS 83
             +   +  + T +A+ ++    + +L L+ GE   ++++    W     ++G+  ++P+
Sbjct: 304 QPTFDMDEGENTVIAVYNYNPVRENQLPLQKGEKYYVVNQSNAQWWYVKNMTGQLGYVPT 363

Query: 84  VYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            YV K        W Y+ ++R++AE +LL      G FL+R+S +++  Y+LSV    P 
Sbjct: 364 NYVHKPNSLNSFDWYYKDITRQQAEAILLDENRE-GCFLVRDSVSKKNTYTLSVTSKDPE 422

Query: 140 SWD--RIRHYRIQRLD 153
           +    ++ HY I R +
Sbjct: 423 APGKLKVHHYHIHRTE 438



 Score = 91.7 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 18/109 (16%), Positives = 40/109 (36%), Gaps = 11/109 (10%)

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
                 Y+S +  FP++  ++ ++   + G+   LR P         P KD   PVT   
Sbjct: 502 NGEAQYYLSEKHAFPTISDVIHYHKHNSGGLVVRLRSP---------PTKDRESPVTAGM 552

Query: 212 SSLNWKKLDRSLLFLEA-PASGEASLLSEGLRESLSSYIS-LAEDPLDD 258
               ++     L         G+  ++  G   ++   +  + E  +++
Sbjct: 553 GLDEFELDPAELHLEREPIGKGQFGVVKRGKFRNIPVAVKQMVEGAMNE 601


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  121 bits (304), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 39/163 (23%), Positives = 62/163 (38%), Gaps = 16/163 (9%)

Query: 55  GEPLTIISE------DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL 108
           GE    ++E      +      +      E   P       +  W +  LS  +AE+LL 
Sbjct: 68  GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLT 127

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRP-----ASWDRIRHYRIQRLDNGWLYISPRL 163
             G   G+FL+RESQ+  G + LSVR          S  ++ H  I+   +    +    
Sbjct: 128 EKGK-NGSFLVRESQSHPGDFVLSVRTGDDKTDSSDSKPKVTHVMIRCQHDLKYDVGGGE 186

Query: 164 TFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKD 202
            F SL  LVEHY +       G    L++P    ++     + 
Sbjct: 187 KFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIES 229



 Score = 94.0 bits (232), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 35/158 (22%), Positives = 61/158 (38%), Gaps = 25/158 (15%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  ++  +AE LLL  G   G+FL R S++  G ++LSVR         + H 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVR-----RNGAVTHI 54

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSEL------ADGICCPLREPCVLQKLGPLPGK 201
           +IQ   + +  +     F +L  LV++Y E        +G    L+ P            
Sbjct: 55  KIQNTGD-YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL----------- 102

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           +   P +      +    +   L  E   +G   L+ E
Sbjct: 103 NCADPTSERWFHGHLSGREAEKLLTEKGKNGSF-LVRE 139


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score =  121 bits (303), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 43/168 (25%), Positives = 71/168 (42%), Gaps = 24/168 (14%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSR+ AE+ L+   N  G FL+RES    G + L++  +       I HY+I R 
Sbjct: 9   WFHGKLSRDDAEK-LIQDLNSEGGFLVRESFASPGDFVLTLLHNGD-----IVHYQILRH 62

Query: 153 -DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
            ++ +  I     F  L  L+ ++ E  +G+   L   C          KD PP  T   
Sbjct: 63  GEDAFFSIDNEHIFHGLETLINYHQENENGLITKLTNFC---------KKDPPPHDT--- 110

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
                +   ++ L   A   G  +++SE L+    +  + +ED    A
Sbjct: 111 -----RCHGKTNLLHRATKEGNYTVVSELLKCGYRNTDAKSEDGQTAA 153



 Score =  100 bits (249), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 6/106 (5%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           +       + W +  L R++A ELL   GN  G++L+R S    G Y L++ ++  +   
Sbjct: 274 APKPVLSKYNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVNDRS--- 330

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
              H++I + +NG+ +I       SL  ++++YS + DG+   L+ 
Sbjct: 331 --FHFQI-KNENGYYFIDDGPLLESLEHVIDYYSRMQDGLPTVLQI 373


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  120 bits (302), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 56/208 (26%), Positives = 88/208 (42%), Gaps = 40/208 (19%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHK-VTAVALGSFPAGEQARLSLRLGEPLTI 60
           GS+ +R   ++  P+       P  +Q  R      VAL SF A     LS + GE L I
Sbjct: 181 GSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEVVVALYSFDASSSEELSFKKGERLEI 240

Query: 61  IS---EDGDWWTVQSEVSGREYHMPSVY--------------------------VAKVAH 91
           +     D DWW  ++  SG    +P  Y                          +     
Sbjct: 241 VDHPEHDPDWWMARN-ASGTTGLVPRNYIEVVNDSSSSKASHQDFAPQYSGNGEIPMEQQ 299

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +SRE+AE+LLL      G FL+R+S++  G  S+S+R       +R +H+++Q 
Sbjct: 300 PWYFGRISRERAEDLLLHGRE--GEFLVRDSESNPGDLSISMR-----GIERNKHFKVQN 352

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELA 179
           +D   L      TF  ++AL+ HY+   
Sbjct: 353 VDG--LLKIGNRTFVDMNALINHYTTSP 378



 Score = 58.2 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 28/57 (49%), Gaps = 1/57 (1%)

Query: 32 HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           +   V    + A E+  L+++  E L ++ +  +WW V ++ +     +PS YV K
Sbjct: 2  SEDYVVVKYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNS-VGFVPSNYVRK 57



 Score = 52.4 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 15/70 (21%), Positives = 26/70 (37%), Gaps = 2/70 (2%)

Query: 19  GPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGRE 78
            P    + M     K  AV   ++    +  L L  G+ + ++ +  D W      +G  
Sbjct: 104 TPSSNKIPMMS--SKTKAVVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGV 161

Query: 79  YHMPSVYVAK 88
              PS YV +
Sbjct: 162 GWFPSNYVEE 171


>UniRef50_Q5BYR6 SJCHGC04559 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BYR6_SCHJA
          Length = 206

 Score =  120 bits (301), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 46/195 (23%), Positives = 70/195 (35%), Gaps = 46/195 (23%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIIS--EDGDWWTVQSEVSGREYHMPSVYVAK-- 88
                A  +F   +   L     E L II+  +D +W   ++ + G    +P  YV +  
Sbjct: 14  GDVVTANYTFKKDKNEDLPFNKNETLKIINIGKDPNWAHAKNTL-GETGLIPLNYVQRKE 72

Query: 89  ------VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
                   H W +  +SR ++E LL   G P G+FLIRES    G  +L V      + +
Sbjct: 73  SALENIQDHCWYHGRISRAESESLL--SGCPIGSFLIRESDLYSGGLTLCVVGPSCMTDN 130

Query: 143 R--------------IRHYRIQRLD-------------------NGWLYISPRLTFPSLH 169
                          ++HYRI R                          +     F SL 
Sbjct: 131 TDATDHQSSTDVMTNVQHYRIVRRPFKPTRFDQCFEYPATPICSKIHYTLDETDWFSSLL 190

Query: 170 ALVEHYSELADGICC 184
            LV+ YS+   G+ C
Sbjct: 191 ELVQFYSQPKRGLVC 205


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score =  120 bits (300), Expect = 6e-26,   Method: Composition-based stats.
 Identities = 54/234 (23%), Positives = 89/234 (38%), Gaps = 62/234 (26%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIIS-- 62
           +S   +   S SS G D       P+   +    L +F       L+    E L IIS  
Sbjct: 165 TSMPNSHGSSTSSKGDDNS----IPDDFVLGVTTLYAFKGRTDEELNFDASELLDIISNP 220

Query: 63  -EDGDWWTVQSEVSGREYHMPSVYVA---------------------------------- 87
            +D DWW  ++++ G    +PS YV                                   
Sbjct: 221 SDDQDWWKARNKL-GTVGLVPSNYVKVVENADPVCPTKFFIEDAVPPKPIEMHDEDNSFT 279

Query: 88  ------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
                      W +  ++R+ +E++L  PG   G FLIRES+T  G +++SV+     + 
Sbjct: 280 PSSSVGFYDRDWFHGRITRQDSEKILGCPG-ESGLFLIRESETMPGDFAVSVK-----AP 333

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA------DGICCPLREP 189
           +R++H+++ R D    +   +  F SL  LV+HY            +   L  P
Sbjct: 334 ERVKHFKVTRSD--KKFCIGQRKFESLDDLVDHYKRSPIFSSDDGELKLYLTRP 385



 Score = 62.1 bits (149), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 21/92 (22%), Positives = 38/92 (41%), Gaps = 6/92 (6%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHK-----VTAVALGSFPAGEQARLSLRLGE 56
           G  + RG      P S    + P     +          A  +  + A ++  L+L  GE
Sbjct: 72  GISAKRGGKPVTRPISPRNSESPHPHTAQPGNEMPFSQPARVMYHYKAAQEDELNLNKGE 131

Query: 57  PLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
            + ++ + GD W  + E +G +   PS YV++
Sbjct: 132 QVNVLEKSGDGWW-RGECNGEKGWFPSNYVSE 162



 Score = 57.1 bits (136), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)

Query: 30 ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
          E   V  VA   + + +   LS++  E L +I +   WW V+ + +GR  ++PS YV +
Sbjct: 3  EEEAVLVVAKWDYDSKQDEELSIKRNEKLKLIDDSRSWWKVEKQ-NGRCGYVPSNYVKR 60


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  119 bits (298), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 47/225 (20%), Positives = 79/225 (35%), Gaps = 53/225 (23%)

Query: 12  SPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWW 68
             S  S+    +P  +  +        L  F +  +  LS      L II +   D DWW
Sbjct: 161 ESSDGSTSEYADPSDVMDKPIISKVRTLYPFKSQSKEELSFDKDIILEIIDKPKDDPDWW 220

Query: 69  TVQSEVSGREYHMPSVYVA------------------------------------KVAHG 92
             +   +G    +P  YV                                          
Sbjct: 221 RARK-SNGEIGLVPRNYVEEIVSPVLTPGPTKPKHSISSLNTNPPIVKDETPDCIFRDKD 279

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LSR + E LL       G +LIR S+++ G +SLS++     + +RI+H++I   
Sbjct: 280 WYHGTLSRSECEFLLNEHAK-DGEYLIRNSESKPGDFSLSMK-----APNRIKHFKILYG 333

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELA-----DGICCPLREPCVL 192
           +N   Y+  + +F ++  L+ HY         +G    L  P   
Sbjct: 334 NN--QYVIGQRSFSNIDELLSHYKNYPIYTTENGQKMHLLYPLNK 376



 Score = 59.7 bits (143), Expect = 9e-08,   Method: Composition-based stats.
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 31 RHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYV 86
            +  A+A   + A     L++R  E L +I +   WW VQ+E S    ++PS Y+
Sbjct: 2  EQESVAIAKYDYTAAGDGELTIRKNEKLVVIDDSQPWWKVQNEKS-VSGYVPSNYL 56



 Score = 44.3 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 17/85 (20%), Positives = 33/85 (38%), Gaps = 2/85 (2%)

Query: 4   LSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
           L ++  +  P  S +   Q   S    +  + A +   +       L L  G+ + +I  
Sbjct: 77  LKNKRTSIDPFDSVTDV-QNIKSKSGAKVLMVAFSKFKYTPQRDDELELNRGDQVLVIEM 135

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAK 88
           + D W  + E +G+    P  Y+ K
Sbjct: 136 EHDGW-CRGECNGKVGWFPFNYIQK 159


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score =  119 bits (298), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 45/198 (22%), Positives = 78/198 (39%), Gaps = 28/198 (14%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTII 61
           GS  +R   S+P   +    +          +VT + + +     +  L L  GE    +
Sbjct: 29  GSFLARPSHSTPGSFTLSVRRG--------DEVTHIRIQN----TEEFLDLYGGEKFATL 76

Query: 62  SE------DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGG 115
           SE      + +    +      E   P +        W +  ++ ++AE++LL  G P  
Sbjct: 77  SELVTYYMENEGQLREKNGDLIELKYPLISEDPTTERWFHGKITGKEAEKMLLERGKPD- 135

Query: 116 AFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHY 175
            FL+RES  R G Y LSV      + +++ H  I    NG   +     F SL  L++ Y
Sbjct: 136 CFLVRESVHRPGSYVLSVL-----TGEQVAHIMIHGKPNGMYDVGGGHQFSSLKELIDFY 190

Query: 176 SELA----DGICCPLREP 189
           +       +G    L++P
Sbjct: 191 TNTPMVEKNGGLVSLKQP 208



 Score = 87.5 bits (215), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 33/116 (28%), Positives = 54/116 (46%), Gaps = 13/116 (11%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           + ++   W +  L+  +AE+LL L G   G+FL R S +  G ++LSVR       D + 
Sbjct: 1   MRQIGGRWFHHNLTGLEAEKLLTLKG-VSGSFLARPSHSTPGSFTLSVR-----RGDEVT 54

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL------ADGICCPLREPCVLQKL 195
           H RIQ  +  +L +     F +L  LV +Y E        +G    L+ P + +  
Sbjct: 55  HIRIQNTEE-FLDLYGGEKFATLSELVTYYMENEGQLREKNGDLIELKYPLISEDP 109


>UniRef50_UPI00016E9C47 UPI00016E9C47 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9C47
          Length = 477

 Score =  119 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 43/166 (25%), Positives = 69/166 (41%), Gaps = 12/166 (7%)

Query: 3   SLSSRGKTSSPSPSSSGPD---QEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
             S +    +P+  + GP+   Q P    P    +T  A  ++       L L+  E  T
Sbjct: 180 RTSRKPLPPTPTEENPGPNVLLQAPEPQGPSV-GMTVTAEYNYLPMTTQDLELKKDEEYT 238

Query: 60  IISEDGDWWTVQSEVSGREYHMPSVYVAK-----VAHGWLYEGLSREKAEELLLLPGNPG 114
           I+      W    +  G E ++PS YV +         W  +  +R +AE+LL    N  
Sbjct: 239 ILEMSDPNWWRARDKYGNEGYIPSNYVVEAENGLERFDWFCKNTNRSQAEKLLRTE-NKD 297

Query: 115 GAFLIRESQTRRGCYSLSVRLS-RPASWDRIRHYRIQRLDNGWLYI 159
           G FL+R+S +R G Y++S+       +    RHY I     G  Y+
Sbjct: 298 GGFLVRDS-SRPGKYTVSLLSKSGGDTGASCRHYNICTTPQGHFYL 342


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  119 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 33/177 (18%), Positives = 70/177 (39%), Gaps = 27/177 (15%)

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           P  +       W +  +SR++A  LL       G FL+R S  +   Y+L+V++      
Sbjct: 506 PEAHAGVEEEPWYHGEISRQEATGLL----KKMGDFLVRYSADKEH-YTLTVKM------ 554

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
           + I+H+ IQ  + G+ +      +PS+  L++H+ +         R P   +    L   
Sbjct: 555 EGIKHFIIQHNEEGFRF--EGDPYPSIPMLIDHHFKN--------RLPVTRKSQAILRQP 604

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
              P +        +     ++L  E    G    + +G  ++ +  +++     +D
Sbjct: 605 VKKPDLR------EYNISHDNILIGEKIGKGNFGDVFKGYLKTHNMEVAVKSCRSED 655


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score =  119 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 54/229 (23%), Positives = 83/229 (36%), Gaps = 59/229 (25%)

Query: 2   GSLSSR--GKTSSPSPSSSGPDQEPVSMQPERHKVTAV-ALGSFPAGEQARLSLRLGEPL 58
           G   S    K+SS   S          +QP    ++ V  L +F +G    L+    E L
Sbjct: 175 GYFPSNYVVKSSSMPQSCPSSMPNTSHVQPASDCISVVRTLYAFNSGNPEELAFEQDEML 234

Query: 59  TIIS---EDGDWWTVQSEVSGREYHMPSVYVA---------------------------- 87
            II    +D +WW  ++   G    +P  YV                             
Sbjct: 235 DIIEQPPDDPEWWLARN-SEGLTGLVPMNYVEVVDGAQPVSSGNIQNYDRVCPQHNDIEN 293

Query: 88  -----------------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
                              +  W +  + R  AE+ L    +  G FL+R S+T  G YS
Sbjct: 294 MHAQNTAIGGNDGAADGIHSRDWYFGNMKRADAEQRLQDRAD-NGEFLVRGSETSSGDYS 352

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           +S+++       RIRH+++  L NG   I  +  F S+ AL+EHY    
Sbjct: 353 ISMKM-----PGRIRHFKVNTLPNGVFGIG-QRKFDSMDALLEHYKSAP 395



 Score = 60.1 bits (144), Expect = 6e-08,   Method: Composition-based stats.
 Identities = 15/56 (26%), Positives = 28/56 (50%), Gaps = 1/56 (1%)

Query: 33 KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
          +   VAL  + A E   LS++  E L ++     WW V++  + +   +PS Y+ +
Sbjct: 6  EEVVVALYDYSAKEGEELSIKKNEQLYLLDAKHTWWRVRNNAN-KIGLVPSNYLRR 60



 Score = 53.6 bits (127), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 16/77 (20%), Positives = 28/77 (36%), Gaps = 2/77 (2%)

Query: 18  SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWT--VQSEVS 75
                              V+  ++ A +   L+LR G  + ++  D D W     +E  
Sbjct: 112 PNLKPPGDGGDRAHMNEEYVSKFNYDATKDDELTLRKGMRVIVLQTDPDGWWYGKDAERP 171

Query: 76  GREYHMPSVYVAKVAHG 92
           G+  + PS YV K +  
Sbjct: 172 GQPGYFPSNYVVKSSSM 188


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  118 bits (295), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 44/168 (26%), Positives = 67/168 (39%), Gaps = 24/168 (14%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +SRE AEE+L   G   G FL+RES +  G Y LSV          + HY I+R
Sbjct: 8   CWFHGKISREDAEEILRREG-SDGVFLVRESSSSEGDYVLSVLFK-----GEVVHYAIRR 61

Query: 152 L-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             D+ +  I        L +L+EHY +    +   L+  C          +  PPP  V 
Sbjct: 62  HGDDAFFSIHDHTPIHGLDSLIEHYQKDKGNLVTRLQVIC----------RSDPPPHDVR 111

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
           +          + L   A      +++SE L+    +  S  +D    
Sbjct: 112 S-------HGTTNLLHRATKESNYTVVSELLKCGYRNIDSKNQDGQTA 152



 Score = 73.2 bits (178), Expect = 9e-12,   Method: Composition-based stats.
 Identities = 39/194 (20%), Positives = 61/194 (31%), Gaps = 44/194 (22%)

Query: 55  GEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL------ 108
           GE  + ++     + V   ++  E   P          W +  L R  A + L       
Sbjct: 250 GEMPSDLARLRGHYQVVEFLNAYEPQRPLT----HRDLWYHGTLERTAAVDYLKDFAVKL 305

Query: 109 ---------------------------LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
                                      L  +  G +L+R S  +     L++        
Sbjct: 306 LPNLAHRQQQQQPDRDGNKENGECLDGLEQSTSGTYLVRYSAKQNVD-VLTMLYDNEPK- 363

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
               H+ IQR  + WLYI       SL  L+EHY+  +DG+   LR P       P+P  
Sbjct: 364 ----HFIIQRQQD-WLYIDEGPYMNSLEHLIEHYTRFSDGLPINLRFPVTPGPKPPIPAF 418

Query: 202 DTPPPVTVPTSSLN 215
            T P         +
Sbjct: 419 ATIPKSKHRMHRTD 432


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  118 bits (295), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 40/177 (22%), Positives = 69/177 (38%), Gaps = 40/177 (22%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVYVAKVA 90
            T  AL  F +G    L+    E + ++ +   D +WW  + E +G+   +P  YV  V 
Sbjct: 147 QTVQALYHFSSGNVEELNFNKYELMDVLEKPENDPEWWKCRKE-NGQVGLVPKNYVTVVQ 205

Query: 91  H----------------------------GWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
                                         W Y  L+R +AE +L   G   G FLIR+S
Sbjct: 206 KTHKELGISGPHPSNYDIKPSMDGKFGGKQWYYGKLTRHQAEMVLNQRG-VDGDFLIRDS 264

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
           ++    +S+S++           H+++   D    +   +  F ++  LVEHY +  
Sbjct: 265 ESMPNDFSISLKALYKNK-----HFKVLLNDG--FFCIGQRKFSTMEDLVEHYKKAP 314



 Score = 43.6 bits (101), Expect = 0.007,   Method: Composition-based stats.
 Identities = 13/53 (24%), Positives = 24/53 (45%), Gaps = 1/53 (1%)

Query: 36  AVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
           A+   ++ A  +  LSL  G  + ++ +  D W  +   +G     PS YV +
Sbjct: 66  ALVKFNYTAEREDELSLVKGTRVIVMEKCSDGWW-RGSYNGLSGWFPSNYVTE 117


>UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax=Euteleostomi
           RepID=GRB10_HUMAN
          Length = 594

 Score =  117 bits (294), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 34/184 (18%), Positives = 67/184 (36%), Gaps = 17/184 (9%)

Query: 19  GPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGRE 78
                  +      + + VA+  F      R+     E  +   E+G  W  +S      
Sbjct: 415 ALLSPFSTPVRSVSENSLVAM-DFSGQT-GRVIENPAEAQSAALEEGHAWRKRSTRMNIL 472

Query: 79  YHMPSVY------VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
                ++      V      W +  +SRE++  ++   G   G FL+R+SQ+    + L+
Sbjct: 473 GSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLT 532

Query: 133 VRLSRPASWDRIRHYRI-QRLDNGWLYI---SPRLTFPSLHALVEHYSELADGICCPLRE 188
           +         +I++++I    D+G  +         F  L  LV+ Y      + C L+ 
Sbjct: 533 L-----CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587

Query: 189 PCVL 192
            C+ 
Sbjct: 588 HCIR 591


>UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=Euteleostomi
           RepID=GRB7_HUMAN
          Length = 532

 Score =  117 bits (293), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 44/197 (22%), Positives = 72/197 (36%), Gaps = 26/197 (13%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGD 66
           + ++    PS  G               T VA+  F +G   R+     E L++  E+  
Sbjct: 348 QAQSRHLHPSCLG-----SPPLRSASDNTLVAM-DF-SGHAGRVIENPREALSVALEEAQ 400

Query: 67  WWTVQSEVSGREYHMPSVYV-------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
            W  +   +     +P                 W +  +SRE+++ L+   G   G FL+
Sbjct: 401 AWRKK---TNHRLSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLV 457

Query: 120 RESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL-DNGWLYI---SPRLTFPSLHALVEHY 175
           RESQ     + LS+         +++HY I    + G LY      +  F  L  LVE +
Sbjct: 458 RESQRNPQGFVLSL-----CHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFH 512

Query: 176 SELADGICCPLREPCVL 192
                 + C LR  C  
Sbjct: 513 QLNRGILPCLLRHCCTR 529


>UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein activator 1 n=1 Tax=Ciona
           intestinalis RepID=UPI000052352E
          Length = 936

 Score =  117 bits (292), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 31/186 (16%), Positives = 62/186 (33%), Gaps = 18/186 (9%)

Query: 20  PDQEPVSMQPERHKVTAVALGSFPA---GEQARLSLRLGEPLTIISE-DGDWWTVQSEVS 75
                   +P   +    A+  +      +   +S    +   +  + +GDW  ++S  +
Sbjct: 145 LRTPIQPPEPVDDRRRVQAILPYQKVPDADNDEISFEKDDIFIVQDDMEGDWMWLESLRT 204

Query: 76  GREYHMPSVYV-------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC 128
                +    V             W + G+++E+A  LL       G+FLIR S +  G 
Sbjct: 205 NERGCVFRGLVRDIGDVDPHEGKEWFHAGITKEEAYSLLSAVDRS-GSFLIRVSDSTPGD 263

Query: 129 YSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
           Y L        +   I+ +++ R+     +      + S+  +VEHY          L  
Sbjct: 264 YVLYFF-----TGQYIQRFKLHRVGQNR-FEMGGRCYGSIDEVVEHYRHEQIVEGHTLTY 317

Query: 189 PCVLQK 194
                 
Sbjct: 318 AVPKST 323



 Score = 85.2 bits (209), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 38/186 (20%), Positives = 63/186 (33%), Gaps = 22/186 (11%)

Query: 43  PAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREK 102
            A  +  + +   E + ++S   ++      + G    +P+         W +  L R  
Sbjct: 19  EASYEQEVEVHEDELVAMMSGSHEF-----SIDGDHVEVPA------KSFWYHGKLDRRI 67

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR 162
           AEE LL   N  G +L+RESQ + G Y LS             H+RI  +   +      
Sbjct: 68  AEERLLEV-NVAGGYLVRESQKKPGSYVLSFLSENIGM----THFRIISVCGDFYI--GG 120

Query: 163 LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
             F  L  L+ +Y+  +    C L    +   + P    D    V            D  
Sbjct: 121 RQFECLEQLIAYYTHRS----CLLEGEVLRTPIQPPEPVDDRRRVQAILPYQKVPDADND 176

Query: 223 LLFLEA 228
            +  E 
Sbjct: 177 EISFEK 182


>UniRef50_Q9UKW4 Guanine nucleotide exchange factor VAV3 n=112 Tax=Euteleostomi
           RepID=VAV3_HUMAN
          Length = 847

 Score =  117 bits (292), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 49/282 (17%), Positives = 90/282 (31%), Gaps = 54/282 (19%)

Query: 2   GSLSS--RGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPA----GEQARLSLRLG 55
           G ++S  +G    P   ++G  + P  + P   K+  +   S        E   L L+ G
Sbjct: 563 GRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAG 622

Query: 56  EPLTIISEDGDW--WTVQSEVSGREYHMPSVYVAKV----------AHGWLYEGLSREKA 103
           + + ++  D     W  ++  SG     PS  V                W    + R +A
Sbjct: 623 DTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQA 682

Query: 104 EELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRL 163
           E  L+   N    +L+R      G Y++S++ +  A   +I         +G+ +I+   
Sbjct: 683 ETELINRVNS--TYLVRHRTKESGEYAISIKYNNEAKHIKI------LTRDGFFHIAENR 734

Query: 164 TFPSLHALVEHYSELADG-----ICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
            F SL  LVE+Y   +       +   L+ P    +       +      +    L    
Sbjct: 735 KFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAI 794

Query: 219 LD--------RSLLFLEAPASGEASLLSE--------GLRES 244
                     R L  L+         + +        G    
Sbjct: 795 ARYDFCARDMRELSLLK-------GDVVKIYTKMSANGWWRG 829



 Score = 47.4 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 4/56 (7%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISED--GDWWTVQSEVSGREYHMPSVYVAK 88
            A+A   F A +   LSL  G+ + I ++     WW  + EV+GR    PS YV +
Sbjct: 792 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWW--RGEVNGRVGWFPSTYVEE 845


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  117 bits (292), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 40/174 (22%), Positives = 70/174 (40%), Gaps = 38/174 (21%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISE---DGDWWTVQSEVSGREYHMPSVYV----- 86
               L  F +  +  L+   GE + +I +   D +WW  ++   G+   +P  YV     
Sbjct: 199 VVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKN-ARGQVGLVPKNYVVVLSD 257

Query: 87  ---------------------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
                                      W Y  ++R +AE  L   G   G FLIR+S++ 
Sbjct: 258 GPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVE-GDFLIRDSESS 316

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
              +S+S++ S         H+++Q +DN  +Y   +  F ++  LVEHY +  
Sbjct: 317 PSDFSVSLKASGKNK-----HFKVQLVDN--VYCIGQRRFHTMDELVEHYKKAP 363



 Score = 57.8 bits (138), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 14/61 (22%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 31 RHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVA 90
            +V  +A   + A +   L ++  E L ++ +   WW V++  + R  ++PS YV +  
Sbjct: 2  TEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAAN-RTGYVPSNYVERKN 60

Query: 91 H 91
           
Sbjct: 61 S 61



 Score = 47.8 bits (112), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 19/86 (22%), Positives = 36/86 (41%), Gaps = 3/86 (3%)

Query: 3   SLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVA--LGSFPAGEQARLSLRLGEPLTI 60
              +  + +SP+PS+        S     + +   A    ++ A  +  LSL  G  +T+
Sbjct: 81  RRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTV 140

Query: 61  ISEDGDWWTVQSEVSGREYHMPSVYV 86
           + +  D W  +   +G+    PS YV
Sbjct: 141 MEKCSDGWW-RGSYNGQIGWFPSNYV 165


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  116 bits (290), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 39/185 (21%), Positives = 69/185 (37%), Gaps = 23/185 (12%)

Query: 55  GEPLTIISE------DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL 108
           GE    ++E      +      +      E   P       +  W +  LS ++AE+LL 
Sbjct: 68  GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLT 127

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW-----DRIRHYRIQRLDNGWLYISPRL 163
             G   G+FL+RESQ+  G + LSVR             ++ H  I+  +     +    
Sbjct: 128 EKGK-HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQE-LKYDVGGGE 185

Query: 164 TFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLN---- 215
            F SL  LVEHY +       G    L++P    ++     +     ++    + +    
Sbjct: 186 RFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQ 245

Query: 216 --WKK 218
             W++
Sbjct: 246 GFWEE 250



 Score = 93.3 bits (230), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 35/158 (22%), Positives = 60/158 (37%), Gaps = 25/158 (15%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  ++  +AE LLL  G   G+FL R S++  G ++LSVR         + H 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVR-----RNGAVTHI 54

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSEL------ADGICCPLREPCVLQKLGPLPGK 201
           +IQ   + +  +     F +L  LV++Y E        +G    L+ P            
Sbjct: 55  KIQNTGD-YYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL----------- 102

Query: 202 DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
           +   P +      +    +   L  E    G   L+ E
Sbjct: 103 NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSF-LVRE 139


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  116 bits (290), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 42/190 (22%), Positives = 72/190 (37%), Gaps = 19/190 (10%)

Query: 55  GEPLTIISEDGDWW-----TVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLL 109
           GE    + E   ++       +      E   P +        W +  LS ++AE+L+L 
Sbjct: 68  GEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILE 127

Query: 110 PGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLH 169
            G   G+FL+RESQ++ G + LSVR       D++ H  I+  D     +    +F +L 
Sbjct: 128 RGK-NGSFLVRESQSKPGDFVLSVRTD-----DKVTHVMIRWQDK-KYDVGGGESFGTLS 180

Query: 170 ALVEHYSELA----DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF 225
            L++HY         G    LR+P    ++    G +      V      W++ +     
Sbjct: 181 ELIDHYKRNPMVETCGTVVHLRQPFNATRIT-AAGINARVEQLVKGGF--WEEFESLQQD 237

Query: 226 LEAPASGEAS 235
                S    
Sbjct: 238 SRDTFSRNEG 247



 Score = 95.6 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 40/172 (23%), Positives = 68/172 (39%), Gaps = 24/172 (13%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  +S  +AE+LL   G   G+FL R S +  G ++LSVR       + + H 
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGF-DGSFLARLSSSNPGAFTLSVR-----RGNEVTHI 54

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSEL-----ADGICCPLREPCVLQKLGPLPGKD 202
           +IQ   + +  +     F +L  LV++Y E       +G    L++P +           
Sbjct: 55  KIQNNGD-FFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLI----------- 102

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAED 254
              P T      N    +   L LE   +G   L+ E   +     +S+  D
Sbjct: 103 CAEPTTERWFHGNLSGKEAEKLILERGKNGSF-LVRESQSKPGDFVLSVRTD 153


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  115 bits (289), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 39/219 (17%), Positives = 69/219 (31%), Gaps = 44/219 (20%)

Query: 43  PAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREK 102
           P+G    L+L                 +++  +  +    S         W +  L RE+
Sbjct: 73  PSGCDDDLTLEQN-------------FIENGYNNEQQISLSTNRPLYEEEWFHGVLPREE 119

Query: 103 AEELLLLPGNPGGAFLIRES-QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP 161
              LL    N  G FL+RE+ +       LSV       W+  +H+ +Q    G      
Sbjct: 120 VVRLL----NNDGDFLVRETIRNEESQIVLSVC------WNGHKHFIVQTTGEGNFRF-E 168

Query: 162 RLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDR 221
              F S+  L+ H    ++        P  ++    L           P     W+  + 
Sbjct: 169 GPPFASIQELIMH-QYHSE-------LPVTVKSGAIL---------RRPVCRERWELSND 211

Query: 222 SLLFLEAPASGEASLLSEGLRES--LSSYISLAEDPLDD 258
            ++ LE    G    + +   +S  L   +      L D
Sbjct: 212 DVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPD 250


>UniRef50_P78453 Tyrosine kinase (Fragment) n=11 Tax=Euteleostomi RepID=P78453_HUMAN
          Length = 177

 Score =  115 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 39/98 (39%), Positives = 54/98 (55%), Gaps = 5/98 (5%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIIS-EDGDWWTVQSEVSGREYHMPSVYVAK---- 88
              +AL  + A  +  L+   GE   I++  +GDWW  +S  SG+   +PS YVA     
Sbjct: 80  TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSI 139

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
            A  W +  + R+ AE  LL PGNP GAFLIRES+T +
Sbjct: 140 QAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177


>UniRef50_UPI00016E4312 UPI00016E4312 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E4312
          Length = 350

 Score =  115 bits (288), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 46/171 (26%), Positives = 73/171 (42%), Gaps = 16/171 (9%)

Query: 30  ERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQ-----SEVSGREYHMPSV 84
              + + VA+  F      R+     E  +   E+G  W  +     S  +      PS+
Sbjct: 183 STSEASLVAM-DFSGKAGGRVIQNPAEAQSAEQEEGQAWRRREALRCSLPNLNSGPKPSL 241

Query: 85  YVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI 144
            V   +  W + G+SR++A+ L+   G   G FLIRESQ    C+ LS+         +I
Sbjct: 242 AVHV-SQPWFHGGVSRKEAQRLIEKQGLVDGMFLIRESQQHGQCFVLSLSHQL-----KI 295

Query: 145 RHYRIQRLDNG---WLYISPRLT-FPSLHALVEHYSELADGICCPLREPCV 191
           +HY +   ++G   +  I   LT F  L  LVE +      +   L+ PCV
Sbjct: 296 KHYLVIPCEDGGRKYFTIDDGLTLFIDLLQLVEFHQINKGILPVCLKHPCV 346


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score =  115 bits (288), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 54/308 (17%), Positives = 92/308 (29%), Gaps = 86/308 (27%)

Query: 24  PVSMQPERHKVTAVALG-SFPAGEQARLSLRLGE-PLTIISEDGDWWTVQSEVSGREYHM 81
           P+ +  ER     V L  S+  G    +    GE P  + S  G+  T +      E + 
Sbjct: 179 PLHLLAERGTAEIVLLLISY--GADVTVINNDGETPRQVASRVGNTQTCRVLSDSEEGYG 236

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
                      + +  L+R  AE ++ + G+  G FL+R S    G + LS+  ++    
Sbjct: 237 VPEIKKLFELEYYHGKLNRVAAENIITIYGSNDGLFLVRFS-KGSGNFILSMCFNQSC-- 293

Query: 142 DRIRHYRIQR-LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL-------- 192
               H++IQ        +I     F SL  L++HY   +DG+ C L   C          
Sbjct: 294 ---FHFQIQCSQAENCYFIDDGPGFTSLGDLIQHYRLKSDGLPCVLTRFCKRSARSGGLS 350

Query: 193 ------------------------------------------QKLGPLPGKDTPPPVTVP 210
                                                     + +   P  DTP P    
Sbjct: 351 PDEEDIYQTGNLKAKKPRSKPVRASTYEEPGKKIPPARPKKKKSMQSRPLPDTPQPQQSK 410

Query: 211 TSSLNWKKLDR---------------------SLLFLEAPASGEASLLSEGLRE----SL 245
                  +LD                       +   +   +GE   +  G  +    S+
Sbjct: 411 DDYDKMAELDELMKRQELVGVKPGKLNSIPYHDIELGDELGAGEFGKVYRGTYKSAAGSI 470

Query: 246 SSYISLAE 253
           S  +   +
Sbjct: 471 SVAVKTLQ 478



 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 7/113 (6%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
           +   + +  + R +AE  +   GN  G FLIR+S +  G Y LSV     A      H++
Sbjct: 1   MDQLFFHGSVPRAEAEAKVQRGGN--GVFLIRQSSSDSGSYVLSVGYQGEA-----LHFK 53

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
           I+     W  I     F  L  L EH+    DG+ C L  P +++       +
Sbjct: 54  IKNEGECWFSIDEGPVFEGLADLTEHFVHFPDGLPCNLTSPVLVRSAEIDYKE 106


>UniRef50_Q64725-2 Isoform SykA of Tyrosine-protein kinase SYK n=35 Tax=Euteleostomi
           RepID=Q64725-2
          Length = 606

 Score =  115 bits (287), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 42/206 (20%), Positives = 66/206 (32%), Gaps = 57/206 (27%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
                W +  +SR+++E+ +L+     G FLIR      G ++L +         ++ HY
Sbjct: 162 HEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNN-GSFALCLL-----HEGKVLHY 215

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG----------- 196
           RI R   G L I     F +L  LVEHYS   DG+   L  PC    +            
Sbjct: 216 RIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHP 275

Query: 197 -PLPGKDTPPPVTVPTSSLN-----W--------------------------KKLDRSLL 224
            P P + + P  TV  +        W                          +   + + 
Sbjct: 276 VPPPPQGSRPESTVSFNPYEPTGGAWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVY 335

Query: 225 FLEA--------PASGEASLLSEGLR 242
                         SG    + +G  
Sbjct: 336 LDRKLLTLEDNELGSGNFGTVKKGYY 361



 Score = 95.6 bits (236), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 35/135 (25%), Positives = 58/135 (42%), Gaps = 13/135 (9%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                 + +  ++RE+AE+ L+  G   G +L+R+S+   G ++LSV  +R A      H
Sbjct: 8   NANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAH-----H 62

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPP 206
           Y I+R  NG   IS      S   L  ++S+  +G+ C L++P                P
Sbjct: 63  YTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQ--------P 114

Query: 207 VTVPTSSLNWKKLDR 221
            T P   L    +  
Sbjct: 115 KTGPFEDLKENLIRE 129


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score =  115 bits (287), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 42/157 (26%), Positives = 66/157 (42%), Gaps = 24/157 (15%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  +SRE+AEE+L   G   G F++RES +  G + LSV            HY+I+R
Sbjct: 8   CWFHGKISRERAEEILRQEGG-DGVFMVRESASSEGDFVLSVLFQDEM-----VHYQIRR 61

Query: 152 L-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             D+ +  I        L +L+EHY E  +G+   L+  C  +          PPP  V 
Sbjct: 62  HGDDAFFSIDDHTPIHGLESLIEHYRESPNGLVTKLQAICRGK----------PPPHDVR 111

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSS 247
           +            L   A  +    ++SE L+    +
Sbjct: 112 S-------HGTENLLHRATQANNFPIVSELLKCGYRN 141



 Score = 59.7 bits (143), Expect = 8e-08,   Method: Composition-based stats.
 Identities = 30/126 (23%), Positives = 45/126 (35%), Gaps = 35/126 (27%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNP----------------------------GGAFLIR 120
               W +  L R+ A ++L                                   G +L+R
Sbjct: 280 NKSQWYHGTLDRQIAVDILKEHAGKLMPGACSPSKEDKENDSTRSNDNETLDTSGVYLVR 339

Query: 121 ESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELAD 180
            S  ++G   L++     A     RH+ IQR    +LYI       SL  L+EHYS  +D
Sbjct: 340 YS-PKQGVDVLTLLFDNEA-----RHFIIQR-KQNYLYIDDGPYMASLEHLIEHYSRFSD 392

Query: 181 GICCPL 186
           G+   L
Sbjct: 393 GLQINL 398


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  114 bits (286), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 33/185 (17%), Positives = 60/185 (32%), Gaps = 44/185 (23%)

Query: 76  GREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
           G+E   P          W +  + R + ++LL       G FL+R+SQ + G Y LSV  
Sbjct: 516 GQEVERPL-----EQQTWYHGAIPRLEVQQLLTK----DGDFLVRKSQEKPG-YVLSVHW 565

Query: 136 SRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC----CPLREPCV 191
           S         H+ +Q  DN  +Y     +F ++  L++ Y      +       LR P +
Sbjct: 566 SGACK-----HFLVQNKDN--MYCLDGESFHTIPQLIQQYQTSQQHVTKKSEVVLRRPVL 618

Query: 192 LQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYI 249
                                   W      ++       G    + +G     +    +
Sbjct: 619 K---------------------DKWVLEHDDIILGHIIGRGNFGEVYKGQLRPDNTPVAV 657

Query: 250 SLAED 254
              ++
Sbjct: 658 KTCKN 662


>UniRef50_B1AH86 GRB2-related adaptor protein 2 (Fragment) n=3 Tax=Tetrapoda
           RepID=B1AH86_HUMAN
          Length = 97

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 37/101 (36%), Positives = 56/101 (55%), Gaps = 4/101 (3%)

Query: 34  VTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           + AVA   F A  +  LS   G+ L I+S   +W+    E+  +E ++P  ++      W
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKA--ELGSQEGYVPKNFIDIQFPKW 58

Query: 94  LYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
            +EGLSR +AE LL+  G   G F+IR SQ+  G +S+SVR
Sbjct: 59  FHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR 97


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score =  114 bits (285), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 38/156 (24%), Positives = 62/156 (39%), Gaps = 21/156 (13%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W +  LSRE  E LL   G P G+FL+RES +  G + LSV        + + H++I+R
Sbjct: 8   FWYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVL-----HNNEVSHFQIRR 62

Query: 152 L-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             ++ +  I        L +L+EHY      +   L     ++   P             
Sbjct: 63  HSEDAFFSIDENTKIHGLESLIEHYVNTKGILSEGLSLTVPVKGDAPPDYS--------- 113

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS 246
                 ++  R+ L   A   G   ++SE L+    
Sbjct: 114 ------RRHGRTNLLHRATKEGNYKVVSEVLKTGYR 143



 Score = 96.7 bits (239), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 32/222 (14%), Positives = 59/222 (26%), Gaps = 53/222 (23%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
                     W +  L R +AE  +       G FL+R S   +    L++      +  
Sbjct: 276 CPAPKTHRSYWYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTL-----INES 329

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPL---------------- 186
              +Y I++ D+ +L+I       SL  ++E+YS + DG+   L                
Sbjct: 330 LFYNYIIRKQDD-YLFIDNGPYLESLEHIIEYYSFIPDGLPTVLQTPVPPKPKPPVPECT 388

Query: 187 REPCVLQKLGPLPGKDTPPPVTVPTS-------------------------SLNWKKLDR 221
             P   +K      +      +                             + +      
Sbjct: 389 TIPRQRKKNLRPQPEIISIAESQSLKCFPSQFQNIHFTTNFSNNNNYTTNDNEDDYIPLE 448

Query: 222 SLLFLEAPASGEASLLSEGLRES-----LSSYISLAEDPLDD 258
            L        GE   + EG         +   I        +
Sbjct: 449 RLKMGRVIGEGEFGSVYEGTYTKRNGEEIKVAIKTVRHEQIE 490


>UniRef50_P43403 Tyrosine-protein kinase ZAP-70 n=14 Tax=Euteleostomi
           RepID=ZAP70_HUMAN
          Length = 619

 Score =  113 bits (283), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 43/227 (18%), Positives = 67/227 (29%), Gaps = 61/227 (26%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
                W +  L+RE+AE  L       G FL+R     +G Y+LS+          + HY
Sbjct: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPR-KEQGTYALSLIY-----GKTVYHY 211

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG----------- 196
            I +   G   I     F +L  LVE+    ADG+   L+E C                 
Sbjct: 212 LISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLP 271

Query: 197 ----------------------PLPGKDTPPPVTVPTS----------SLNWKKLDRSLL 224
                                 P P + T P    P            S   +  D+ L 
Sbjct: 272 AHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLF 331

Query: 225 FLE--------APASGEASLLSEGLR----ESLSSYISLAEDPLDDA 259
                          G    + +G+     + +   I + +   + A
Sbjct: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA 378



 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 39/112 (34%), Positives = 50/112 (44%), Gaps = 6/112 (5%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              + Y  +SR +AEE L L G   G FL+R+     G Y LS+         R  H+ I
Sbjct: 7   HLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV-----RFHHFPI 61

Query: 150 QRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQK-LGPLPG 200
           +R  NG   I+          L E YS   DG+ C LR+PC     L P PG
Sbjct: 62  ERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPG 113


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score =  113 bits (283), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 47/210 (22%), Positives = 71/210 (33%), Gaps = 31/210 (14%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTI 60
           +GS   R                       R     VA+  F  G + R+     E + +
Sbjct: 532 LGSYRQRMLMQESQAKEEWARSPQGPGGKNR-----VAM-DFT-GYRGRVIANPNEAVAV 584

Query: 61  ISEDGDWWTVQSEVSGR---------EYHMP------SVYVAKVAHGWLYEGLSREKAEE 105
             E+G  W  +     R             P      S         W + G++RE+A  
Sbjct: 585 AVEEGQSWRKRHSSGSRALVGSPRNSPLLSPRSSRFISPQGVHQTQPWFHHGINREEANN 644

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL--DNGWLY--ISP 161
           ++ + G   G +L+RESQT  G + L+          R++HY+IQ    D+   Y     
Sbjct: 645 MMHMQGMVDGLYLVRESQTFPGTFVLTF-----CHDQRVKHYQIQPNVIDDKTFYSLDEG 699

Query: 162 RLTFPSLHALVEHYSELADGICCPLREPCV 191
              F  L  LVE Y      +   L  PC 
Sbjct: 700 ETKFGDLVQLVEFYQINRGALPHSLTHPCT 729


>UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine kinase n=3
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48523
          Length = 837

 Score =  112 bits (281), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 53/126 (42%), Gaps = 5/126 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++R+ A  +L   G+  G FL+RES +R G Y +S+           +H++IQ +
Sbjct: 76  WFHGRITRDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSI-----MHNGLPQHFQIQCM 130

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
            + +  I     F  L  L+ +Y   ++G+   L   C  +   P   +          +
Sbjct: 131 GDFYYKIDNGPLFQGLDQLINYYRMGSNGLPTKLTVFCNGRIPPPCSRRFGRTTPLHRAT 190

Query: 213 SLNWKK 218
              W +
Sbjct: 191 FEKWSE 196



 Score = 95.2 bits (235), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 9/128 (7%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
                  W +  + R+KA E +   G   G FL+R S  +     LS+     A+   + 
Sbjct: 344 PRLQGKPWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSM-----AANGTVF 398

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGP---LPGKD 202
           ++ I        YI     F +L  L++HYS   DG+   L  P            P ++
Sbjct: 399 NFEINTKME-SFYIDDGPYFDTLEQLIDHYSRYDDGLPTMLLHPIPPPPGRIDNGPPTRE 457

Query: 203 TPPPVTVP 210
            P P   P
Sbjct: 458 KPSPAPRP 465


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score =  112 bits (281), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 7/120 (5%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
           + W +  +SR+  E LL       G+FL+R S++  G  S++VR        R+ HYRI 
Sbjct: 76  YSWYHGAVSRQAGEHLLR--SGITGSFLVRASESAPGQLSVTVR-----HLGRVYHYRIS 128

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
           +   G  YI+    FP++  L+EH+S  ADG+ CPL       +    P + +       
Sbjct: 129 QDSRGLFYITEAHRFPTVVQLIEHHSRSADGLVCPLLYSVPKPQFLNQPMQQSCYSSVPQ 188


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 43/174 (24%), Positives = 71/174 (40%), Gaps = 28/174 (16%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRI 149
              W +  LSRE A+ELL   G   G FL+RES T  G + LS+          + HY++
Sbjct: 7   PMKWYHGNLSREAADELL-KQGYEDGTFLVRESSTAAGDFVLSLLCQ-----GEVCHYQV 60

Query: 150 QRL--DNGWLYISPR---LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTP 204
           +R   ++ +  I  +        L  LV++Y + A+G+   L  P +          D P
Sbjct: 61  RRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIR---------DLP 111

Query: 205 PPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
           P  T      N        L   A +  E+ ++ E L+    ++ +  +D    
Sbjct: 112 PHNTRSHGVTN--------LLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTA 157



 Score = 82.9 bits (203), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 29/144 (20%), Positives = 52/144 (36%), Gaps = 18/144 (12%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNP----------GGAFLIRESQTRR-GCYSLSVRL 135
                 W +  L+RE+A  +L                 G FL+R S++       L++  
Sbjct: 282 NTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLC 341

Query: 136 SRPASWDRIRH-------YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
            +     RI          ++Q   + +LYI     +PS+  L+ H+   + G+   L+ 
Sbjct: 342 DQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKY 401

Query: 189 PCVLQKLGPLPGKDTPPPVTVPTS 212
           P   Q    +P   T P   +   
Sbjct: 402 PVPPQPKPEVPSFATIPRSNMKPK 425


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score =  111 bits (277), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 42/173 (24%), Positives = 72/173 (41%), Gaps = 28/173 (16%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  LSRE A++LL   G   G FL+RES T  G + LS+        + + HY+++
Sbjct: 8   MKWFHGNLSREAADDLL-KQGYEDGTFLVRESSTAAGDFVLSLLCQ-----EEVCHYQVR 61

Query: 151 RL--DNGWLYISPR---LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           R   ++ +  I  +        L  LV++Y + A+G+   L  P +          D PP
Sbjct: 62  RHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIR---------DPPP 112

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
             T      N        L   A +  E+ ++ E L+    ++ +  +D    
Sbjct: 113 HNTRSHGVTN--------LLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTA 157



 Score = 78.2 bits (191), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 33/147 (22%), Positives = 55/147 (37%), Gaps = 23/147 (15%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNP----------GGAFLIRESQTRRGC-YSLSVRL 135
                 W +   SRE+A   L                 G FL+R S++       L++  
Sbjct: 282 NTTREQWYHGTQSREEAVANLKKFAKELESKNPQIDTSGCFLVRYSESAAATGLVLTLFC 341

Query: 136 SRPASWDRIRH-------YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
            + A   RI          ++Q   + +LYI     +PSL  L+ H+   + G+   L+ 
Sbjct: 342 DQVAKNFRISQADLYQNGVKLQSGGSKFLYIDDGPYWPSLEHLIAHFMRFSYGLPVSLKY 401

Query: 189 PCVLQKLGPLPGKDTPPPVTVPTSSLN 215
           P       PLP  + P   T+P + + 
Sbjct: 402 PVP-----PLPKPEVPSFATIPRALVK 423


>UniRef50_Q291J2 GA14852 n=4 Tax=Drosophila RepID=Q291J2_DROPS
          Length = 938

 Score =  110 bits (276), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 40/176 (22%), Positives = 72/176 (40%), Gaps = 27/176 (15%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                 W +  LSRE A++LL   G   G FL+RES T  G + LS+        + + H
Sbjct: 3   RDDHMKWFHANLSREAADDLLR-QGYEDGTFLVRESSTAAGDFVLSILCQ-----EEVCH 56

Query: 147 YRIQRL-DNGWLYISPR---LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           Y+++R  ++ +  I           L  LV++Y + A+G+   L  P +          D
Sbjct: 57  YQVRRHGEDAFFSIDDEMQTKILHGLETLVDYYQQGANGLPTKLTVPLIR---------D 107

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDD 258
            PP  T        ++   + L   A +  E+ ++ E L+    ++ +  +     
Sbjct: 108 PPPHNT--------RRHGMTNLLHRATSKNESKVVFELLKCGYRNFDAKNQHGQTA 155



 Score = 67.8 bits (164), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 25/138 (18%), Positives = 50/138 (36%), Gaps = 18/138 (13%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNP----------GGAFLIRESQTRR-GCYSLSVRLSRP 138
              W +   +R++A   L                 G FL+R S++       L++   + 
Sbjct: 283 REQWYHGTQTRDEAVATLTQYAKELLAKQPGVDTSGCFLVRYSESPAASGLVLTLLSDQV 342

Query: 139 ASWDRIRH-------YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
               RI          ++Q  +  +++I     +PSL  L+ ++   + G+   L+    
Sbjct: 343 VKNFRISQAYLYTNGVKVQSDEQKFVFIDDGPYWPSLEHLIANFMRFSYGLPVSLKYAVP 402

Query: 192 LQKLGPLPGKDTPPPVTV 209
            +    +P   T P  TV
Sbjct: 403 PKPKPEVPSFATIPRSTV 420


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score =  110 bits (275), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 32/175 (18%), Positives = 61/175 (34%), Gaps = 36/175 (20%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG---CYSLSVRLSRPASWDRIR 145
               W +  L RE  + +L       G FLIR ++ ++G    Y LS   +       ++
Sbjct: 7   HTEPWYHGLLPREDIKAMLRK----TGDFLIRSTEPKQGEARQYVLSAMQNEELEDAGVK 62

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC--CPLREPCVLQKLGPLPGKDT 203
           HY ++   N  +++     F ++ +LV +Y    D I     L+ P V Q          
Sbjct: 63  HYVMRVNANNQIFL-ETKGFETITSLVNYYMTTKDPIKKMTVLKTPIVKQ---------- 111

Query: 204 PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG---LRESL--SSYISLAE 253
                      +W+     +   +    G    + +G   ++        I  A+
Sbjct: 112 -----------DWEIEHSQVELTKKLGEGAFGEVWKGKITMKNGKVEDCAIKTAK 155


>UniRef50_Q70W05 Src protein (Fragment) n=1 Tax=Ciona intestinalis
           RepID=Q70W05_CIOIN
          Length = 355

 Score =  110 bits (275), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 34/148 (22%), Positives = 56/148 (37%), Gaps = 10/148 (6%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSG 76
           S+     P    P+  +   +AL  + A     L+ + G+ + I+ +  +W   Q     
Sbjct: 5   STPIQDRPAPPIPQIEEDIYIALYDYVARTNEDLTFKKGDTMVILKKGENWSIAQLLEPN 64

Query: 77  R-----EYHMPSVYVAKV-----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
                 E  +P+ YV K         W+++   R +A  LL+ P N  G FL R   T  
Sbjct: 65  PLYSVTEGSIPTNYVKKQSSVVSQPSWMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNP 124

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRLDN 154
             Y+LS      A    I    I+  + 
Sbjct: 125 NEYALSGLSHDLADEWEIDRKSIELKEK 152



 Score = 68.2 bits (165), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 12/81 (14%), Positives = 20/81 (24%), Gaps = 6/81 (7%)

Query: 183 CCPLREPCVLQKLGPLPGKDTPPP--VTVPTSSL---NWKKLDRSLLFLEAPASGEASLL 237
              L +PC          + T P        S      W+   +S+   E    G    +
Sbjct: 102 VSLLMQPCNNHGDFLARRRTTNPNEYALSGLSHDLADEWEIDRKSIELKEKLGKGNFGEV 161

Query: 238 SEGLRES-LSSYISLAEDPLD 257
            +GL        +        
Sbjct: 162 YKGLWNGTTRVAVKKMIKSEK 182


>UniRef50_UPI000180BC98 PREDICTED: similar to V-yes-1 Yamaguchi sarcoma viral oncogene
           homolog 1 n=1 Tax=Ciona intestinalis RepID=UPI000180BC98
          Length = 432

 Score =  110 bits (274), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 39/160 (24%), Positives = 63/160 (39%), Gaps = 10/160 (6%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
               +  +SRE+AE  LL  G   G FL+R+     G Y +S+  S      R+ +YR++
Sbjct: 23  EPCYFGTISREEAETNLLERGENDGTFLVRKGTD--GEYRISLLSSTSDGSCRVYNYRVK 80

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
              N    I    +FP++H LV +YS+   G+   L  PC  + L   P     P + V 
Sbjct: 81  LATNRTYSIDDTYSFPAVHQLVRYYSQKCSGLPSKLVAPCPKEDLEKEPESGFHPLLPV- 139

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYIS 250
                      S+      + G  S + +      +    
Sbjct: 140 -------IAGSSVEMRSQLSCGSYSEIWKANYLRTTFAAK 172


>UniRef50_Q4JSB7 Tensin n=4 Tax=Culicidae RepID=Q4JSB7_ANOGA
          Length = 1494

 Score =  109 bits (273), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 39/210 (18%), Positives = 73/210 (34%), Gaps = 30/210 (14%)

Query: 6    SRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGS-----FPAGEQARLSLRLGEPLTI 60
            +       S  +S P   P S   +R  +T           +    +   S        +
Sbjct: 1119 TPRTPYGLSNGTSSPALPPKSPTSQR--ITLPGRYEARNPAYQRTTKDLFSGNQQRTQEL 1176

Query: 61   ISEDGD---WWTVQSEVSGREYHMP-------SVYVAKVAHGWLYEGLSREKAEELLLLP 110
            ++++     + + ++  +      P         +    +  W    +SRE+A  LL   
Sbjct: 1177 VNQNETLSCYTSRRNSTTSNANSEPQEVAPQFVKFARDSSKYWYKPNISREEAIALLRNA 1236

Query: 111  GNPGGAFLIRESQTRRGCYSLSVRLSRPA---------SWDRIRHYRIQRLDNGWLY--I 159
                G F++R+S T    Y L V+++ P          S + +RH+ ++    G      
Sbjct: 1237 --APGTFIVRDSTTFANAYGLVVKVNHPPPGVQYTGPNSEELVRHFLVEPTIRGVRLKGC 1294

Query: 160  SPRLTFPSLHALVEHYSELADGICCPLREP 189
            +    F SL ALV  +S     + C L  P
Sbjct: 1295 ANEPVFTSLSALVYQHSITPLALPCRLIIP 1324


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score =  109 bits (273), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 6/136 (4%)

Query: 69  TVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC 128
                    +       +      W +  LSRE+AE+ ++  G   G FL+RE  T  G 
Sbjct: 187 KALHSTQRPQLERALKKIMHQDKPWFHHKLSREEAEQRIVSAGLQEGKFLVRER-TEEGS 245

Query: 129 YSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLRE 188
           ++LS+  +       + HY+I +   G L I     F SL  +V+HY    DG+ C L  
Sbjct: 246 FALSLCYNNF-----VYHYKIDKDCTGQLSIKEGPKFDSLIQMVDHYQLKKDGLLCCLLV 300

Query: 189 PCVLQKLGPLPGKDTP 204
           PC          +   
Sbjct: 301 PCHDNNRDTPTRRRHS 316



 Score = 97.9 bits (242), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 5/134 (3%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           V  ++  + +  ++RE+AE  L   G   G FL+RES  R G Y+LS+          + 
Sbjct: 49  VDPLSRRFYHGRITREEAEARLRNAGCHQGMFLLRESLGREGNYALSLCYEDD-----VY 103

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HY I+R  +G + I     F     LV ++    DG+ C L  PC LQ+           
Sbjct: 104 HYAIERQYDGTVAIKDGKNFAGPIELVSNHMNREDGLLCRLLRPCNLQQGIAARAFSDMD 163

Query: 206 PVTVPTSSLNWKKL 219
              +  + ++  K 
Sbjct: 164 HQQMEGALIDLAKS 177


>UniRef50_UPI0000EB251F Tyrosine-protein kinase Tec (EC 2.7.10.2). n=2 Tax=Euteleostomi
           RepID=UPI0000EB251F
          Length = 236

 Score =  109 bits (273), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 23/113 (20%), Positives = 41/113 (36%), Gaps = 11/113 (9%)

Query: 146 HYRIQRLDN--GWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           HY I+         Y++ +  F S+  ++E++   A G+   LR P   +        + 
Sbjct: 2   HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTK--------EK 53

Query: 204 PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LRESLSSYISLAEDP 255
             P T   S   W+     L F+    SG   ++  G  R      I   ++ 
Sbjct: 54  NAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIKEG 106


>UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene vav n=1 Tax=Homo
           sapiens RepID=B4DVK9_HUMAN
          Length = 748

 Score =  109 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 37/220 (16%), Positives = 69/220 (31%), Gaps = 38/220 (17%)

Query: 50  LSLRLGEPLTI--ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG---------WLYEGL 98
           L L  G+ + +     + +WW  ++  +      P   V    HG         W    +
Sbjct: 520 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPM 579

Query: 99  SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLY 158
            R  AE +L       G FL+R+       +++S++ +       ++H +I     G   
Sbjct: 580 ERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVE-----VKHIKIM-TAEGLYR 631

Query: 159 ISPRLTFPSLHALVEHYSELAD-----GICCPLREPC---VLQKLGPLPGKDTPPPVTVP 210
           I+ +  F  L  LVE Y + +       +   L+ P      + +       T    T  
Sbjct: 632 ITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAK 691

Query: 211 TSSLNWKKLDRSLLFLE----AP--ASGEASLLSEGLRES 244
                  +    L   E          G+     +G    
Sbjct: 692 ARYDFCARDRSELSLKEGDIIKILNKKGQ-----QGWWRG 726



 Score = 56.3 bits (134), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 31/59 (52%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           TA A   F A +++ LSL+ G+ + I+++ G     + E+ GR    P+ YV +    +
Sbjct: 689 TAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEY 747


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score =  109 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 16/150 (10%)

Query: 55  GEPLTIISEDGDWWTVQS------EVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLL 108
           GE    +SE  +++T ++      + +  E   P          W +  LS   AE+LL 
Sbjct: 66  GEKFATLSELVEYYTAENGILQDKDGTIIELKYPFNCSDPTTERWYHGHLSGPNAEKLLW 125

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSV----RLSRPASWDRIRHYRIQRLDNGWLYISPRLT 164
               P G FL+RES ++ G + LSV    +    +   R+ H +I   ++    +  +  
Sbjct: 126 ERDEP-GTFLVRESLSKPGDFVLSVLTEEKSKASSGGRRVSHIKIMCQNDR-YTVGGKEM 183

Query: 165 FPSLHALVEHYSE----LADGICCPLREPC 190
           F +L  L+EHY         G    L++P 
Sbjct: 184 FDTLADLMEHYKRKGIEEMSGTWVHLKQPY 213



 Score =  103 bits (256), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 41/173 (23%), Positives = 67/173 (38%), Gaps = 25/173 (14%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +S   AE +L   G   G+FL R S+  +G +SLSVR+      + + H RIQ  
Sbjct: 4   WFHRDISGLDAESVLKSRG-VHGSFLARPSRKNQGDFSLSVRV-----GELVTHIRIQNT 57

Query: 153 DNGWLYISPRLTFPSLHALVEHYS------ELADGICCPLREPCVLQKLGPLPGKDTPPP 206
            + +  +     F +L  LVE+Y+      +  DG    L+ P            +   P
Sbjct: 58  GD-FYDLYGGEKFATLSELVEYYTAENGILQDKDGTIIELKYP-----------FNCSDP 105

Query: 207 VTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAEDPLDDA 259
            T      +    +   L  E    G   L+ E L +     +S+  +    A
Sbjct: 106 TTERWYHGHLSGPNAEKLLWERDEPGTF-LVRESLSKPGDFVLSVLTEEKSKA 157


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  109 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 24/182 (13%), Positives = 58/182 (31%), Gaps = 30/182 (16%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
           S+        + +  + R   E LL       G FL+R+++   G   L++ +      +
Sbjct: 14  SITDDVKGADYYHGLIPRTDIEPLL----KKEGDFLLRKTELTPGEIVLAISVR---HNN 66

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
            +RH+ + +  +G  Y        S+  L+++Y    + +                    
Sbjct: 67  AVRHFMVNQDQDGSFYCEHHHE-KSVSDLIQYYKSTKEPL-----------------SAS 108

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLR----ESLSSYIS-LAEDPLD 257
           +   +  P     W     S+  ++    G    +         E     +  + ++   
Sbjct: 109 SQARLRRPIERPQWLLNHDSIRLVKKLGEGAFGEVFLAEYSFGTEKQEVAVKTMRQEATR 168

Query: 258 DA 259
           +A
Sbjct: 169 EA 170


>UniRef50_Q5BXE5 SJCHGC04002 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BXE5_SCHJA
          Length = 240

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 42/156 (26%), Positives = 59/156 (37%), Gaps = 9/156 (5%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               W    L RE A ELL       G+FL+R S T  GC +LSVR+    +   I HY 
Sbjct: 82  NQAPWYQALLPREIAFELLARE--EVGSFLVRNSATHPGCCALSVRVPNKDNPLGITHYL 139

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR------EPCVLQKLGPLPGKD 202
           IQ+   G         +PSL ALV H + + + + CPL+       P   Q        D
Sbjct: 140 IQKTSQGVRLKGLDKEWPSLQALVTHLTVIPEMLPCPLKLSQYTANPIFTQ-FDLQLTND 198

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLS 238
               +T    + N +     +       +   S   
Sbjct: 199 PSKEITGQQRNYNIRLSRTEVGDNNRITNSNLSSHH 234


>UniRef50_P53356 Tyrosine-protein kinase HTK16 n=3 Tax=Hydra RepID=HTK16_HYDAT
          Length = 757

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 35/131 (26%), Positives = 53/131 (40%), Gaps = 5/131 (3%)

Query: 82  PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASW 141
           P          WL++ L R  A  +L       G+FLIR S    G Y L++   +    
Sbjct: 276 PVNQPKTSITQWLHQNLDRNGALIILQNASMADGSFLIRSSIKCHGYYVLTLVYEKKT-- 333

Query: 142 DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
               H++I+   + W YI     F +L  LV+HY + ADG+   L+ P    +    P  
Sbjct: 334 ---YHFQIKSRADRWFYIDDGPLFETLPHLVDHYMQYADGLPTLLQFPVPSAENRKRPLP 390

Query: 202 DTPPPVTVPTS 212
            TP    +   
Sbjct: 391 PTPTKNQLKLP 401



 Score =  102 bits (255), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 5/101 (4%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  ++RE A ++LL  G   G FLIR+       Y LS+         +I H++I  L
Sbjct: 10  WYHGKITREVAVQVLLRKGGRDGFFLIRDCGNAPEDYVLSMMFRS-----QILHFQINCL 64

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
            +    I     F  L  L+ +Y  ++DG+ C L + CV +
Sbjct: 65  GDNKFSIDNGPIFQGLDMLISYYKVISDGLPCKLVDFCVGK 105


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 35/228 (15%), Positives = 70/228 (30%), Gaps = 52/228 (22%)

Query: 17  SSGPDQEPVSMQPERHKVTAVALGSFPAGEQAR-----LSLRLGEPLTIISE-DGDWWTV 70
                      +P   +    A+  +             +   G+   + +E D  W  V
Sbjct: 269 GEKLLSPVAPPEPVEDRRRVRAILPYTKVPDTDEIRQVSTFLQGDMFIVHNELDDGWMWV 328

Query: 71  QSEVSGREYHMPSVYV--------AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
            +  +  +  +    V              W +  +++++A  LL+  G    +FL+R S
Sbjct: 329 SNVRTEEQGLIVKDLVEEVGREEDPHEGKVWYHGHITKKEAYNLLMTVGQVC-SFLVRPS 387

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR-------------------- 162
               G YSL  R     + D I+ ++I    N    +  R                    
Sbjct: 388 DNTPGDYSLFFR-----TNDIIQRFKISPTSNNQYMMGGRYYNRYEPICMLGHHFQSSGY 442

Query: 163 LTF------------PSLHALVEHYSELADGICCPLREPCVLQKLGPL 198
             F             S+  +++HY +        L+EP  +Q+   +
Sbjct: 443 HVFSFFLRFNCAASVDSVDDIIDHYKKEQIVEGYNLKEPVSVQQQEQV 490



 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 36/148 (24%), Positives = 59/148 (39%), Gaps = 10/148 (6%)

Query: 81  MPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
            PS +       W +  L R  AEE L    NP G++LIRES  R G + LS        
Sbjct: 173 PPSNHSPPRMPRWYHGKLDRTIAEERLRQARNP-GSYLIRESDRRPGSFVLSFLSMT--- 228

Query: 141 WDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC-CPLREPCVLQKLGPLP 199
            + + H+RI  +   +        F SL  L+ +YS ++  +    L  P       P+ 
Sbjct: 229 -NVVNHFRIIAMCGDYYI--GGRRFSSLSDLIGYYSYVSCLLKGEKLLSPV--APPEPVE 283

Query: 200 GKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
            +     +   T   +  ++ +   FL+
Sbjct: 284 DRRRVRAILPYTKVPDTDEIRQVSTFLQ 311


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 31/110 (28%), Positives = 47/110 (42%), Gaps = 6/110 (5%)

Query: 84  VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDR 143
                +   W + GL+R++   L    G   G FLIRESQ   G + LS      +   +
Sbjct: 651 NSGIHMTQPWFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSF-----SHNQK 705

Query: 144 IRHYRIQRLDNGWLYI-SPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
           ++HY+I  +++G   I      F  L  LVE Y   + G+   L   C  
Sbjct: 706 VKHYQINMVEDGVYTIDDGGTRFTDLIQLVEFYQLNSGGLPTRLLHICTK 755


>UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax=Brugia malayi
           RepID=A8P4D4_BRUMA
          Length = 428

 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 33/173 (19%), Positives = 56/173 (32%), Gaps = 26/173 (15%)

Query: 90  AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRI-RHYR 148
              + +  L RE    LL+      G FL+R S+T        +          I RH  
Sbjct: 8   DENYYHGLLPREDLPHLLINE----GDFLVRSSETAPNQPRQVIISILVEKRGAILRHIV 63

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           +Q+   G      R +F S+  L++ Y +            C    L  +P       +T
Sbjct: 64  VQQNAYGKYVTDARASFDSVPELIQFYQK------------CGEPVLSTVPKAVLKRAIT 111

Query: 209 VPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE-----SLSSYISLAEDPL 256
            P     W+    +++       GE   +  G  +      +   I LA+   
Sbjct: 112 RPP----WELRHETVIIENKIGEGEFGEVFSGKYKLPTGRVIEVAIKLAKTAE 160


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  107 bits (268), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 35/179 (19%), Positives = 58/179 (32%), Gaps = 31/179 (17%)

Query: 83   SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES-QTRRGCYSLSVRLSRPASW 141
            S         W +  L RE+   LL    N  G FL+RE+ +       LSV       W
Sbjct: 950  STNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVC------W 999

Query: 142  DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGK 201
            +  +H+ +Q    G         F S+  L+ H    ++        P  ++    L   
Sbjct: 1000 NGHKHFIVQTTGEGNFRF-EGPPFASIQELIMH-QYHSE-------LPVTVKSGAIL--- 1047

Query: 202  DTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRES--LSSYISLAEDPLDD 258
                    P     W+  +  ++ LE    G    + +   +S  L   +      L D
Sbjct: 1048 ------RRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPD 1100


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score =  107 bits (267), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 38/174 (21%), Positives = 69/174 (39%), Gaps = 28/174 (16%)

Query: 7   RGKTSSPSPSSSGPDQEPVSMQPERH-KVTAVALGSFPAGEQARLSLRLGEPLTIISEDG 65
           + K S P  +S   D      +      + A    ++ A  +  LSL  G          
Sbjct: 17  KRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKG---------- 66

Query: 66  DWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR 125
                    +  +Y  PS+      + W Y  ++R +AE  L   G+  G FLIR+S++ 
Sbjct: 67  ---------TKCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHE-GDFLIRDSESS 116

Query: 126 RGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELA 179
              +S+S++           H+++Q  +   +Y   +  F ++  LVEHY +  
Sbjct: 117 PNDFSVSLKAQGKNK-----HFKVQLKET--VYCIGQRKFSTMEELVEHYKKAP 163


>UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos taurus
           RepID=UPI000179EA7A
          Length = 279

 Score =  107 bits (267), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 36/220 (16%), Positives = 70/220 (31%), Gaps = 38/220 (17%)

Query: 50  LSLRLGEPLTI--ISEDGDWWTVQSEVSGREYHMPSVYVAKVAHG---------WLYEGL 98
           L L  G+ + +     + +WW  ++  +      P   V    HG         W    +
Sbjct: 51  LRLNPGDIVELTKAEAEQNWWEGRNISTNEVGWFPCNRVKPYVHGPPQDLSVHLWYAGPM 110

Query: 99  SREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLY 158
            R  AE +L       G FL+R+       +++S++ +       ++H +I     G   
Sbjct: 111 ERAGAESILT--NRSDGTFLVRQRVKDAAEFAISIKYNVE-----VKHIKIM-TAEGLYR 162

Query: 159 ISPRLTFPSLHALVEHYSELAD-----GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSS 213
           I+ +  F  L  LVE Y + +       +   L+ P    +   +            T+ 
Sbjct: 163 ITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPERRAINKPSAGSIKIFGTAK 222

Query: 214 LNW---KKLDRSLLFLE----AP--ASGEASLLSEGLRES 244
             +    +    L   E          G+     +G    
Sbjct: 223 ARYDFCARDRSELSLKEGDIVKILNKKGQ-----QGWWRG 257



 Score = 57.1 bits (136), Expect = 7e-07,   Method: Composition-based stats.
 Identities = 18/59 (30%), Positives = 31/59 (52%)

Query: 35  TAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGW 93
           TA A   F A +++ LSL+ G+ + I+++ G     + E+ GR    PS YV +    +
Sbjct: 220 TAKARYDFCARDRSELSLKEGDIVKILNKKGQQGWWRGEIYGRIGWFPSNYVEEDYSEY 278


>UniRef50_Q20933 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q20933_CAEEL
          Length = 444

 Score =  107 bits (267), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 27/172 (15%), Positives = 61/172 (35%), Gaps = 27/172 (15%)

Query: 86  VAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIR 145
           +      + +  L RE+ + LL       G +L+R S+ +     L + + +  +   + 
Sbjct: 1   MEINEQPFFHGLLPREEVKLLLQK----NGDYLMRTSEPQGQARHLIISVMQNETSQEVA 56

Query: 146 HYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPP 205
           HY I R  +G   I+ ++ F +L  LV H+ +                    +  +    
Sbjct: 57  HYVI-RTSDGAYSITDKIKFGTLTELVNHHKQ------------------AKISEEVASS 97

Query: 206 PVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE----SLSSYISLAE 253
            +  P    +W+     +   +    G    +  G  +    ++   I +A+
Sbjct: 98  VLVNPIGRQSWELNHADITMTKVLGEGAFGEVKLGTLKMGSTTVDVAIKVAK 149


>UniRef50_Q9Y1Y4 Tyrosine-protein kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y4_9METZ
          Length = 853

 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 56/314 (17%), Positives = 96/314 (30%), Gaps = 93/314 (29%)

Query: 11  SSPSPSSSGPDQEPVSMQ-----PERHKVTAVALGS--FPAGEQARLSLRLGEPLTIISE 63
             PS +++G +QE  S            V    L +  +     A  S+  G+PL I S+
Sbjct: 286 RDPSEATTGAEQELPSKWTLLFTKTEDTVCFSTLLNAYYQIMVDANFSILEGDPLIIPSD 345

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
           +                +      K      +  +S +  E++L +     G FLIRES+
Sbjct: 346 EM-------------LKISENDECKAELC--HVAISPDSVEKVLEMYNKEDGTFLIRESR 390

Query: 124 TRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYI---------SPRLTFPSLHALVEH 174
           +    Y+LS+         RI+++RI R  +G L +          P  +FPS+ ALVEH
Sbjct: 391 SSENSYTLSL-----CHNQRIKNFRISRDTDGSLSLKDPAGSTAEQPIKSFPSMAALVEH 445

Query: 175 YSELADGICCPLREPCVLQKLGP------------------------------------- 197
           +    DG+   L+  C  +++                                       
Sbjct: 446 HKTEKDGLPTHLKINCSPKEVAKTAGAIPLVILKHVAAHRDSSPSTSDGADSAPPALDSP 505

Query: 198 ---------LPGKDTPPPVTVPTSSLNW------KKLDRSLLFLEAPASGEASLLSEGLR 242
                     P  D          +               L   +   SG  S +     
Sbjct: 506 QLPSPALGEEPNPDPSSQKPKHPKTDALVKGGVSWVPFEQLKLSKKLGSGHFSNVYAATW 565

Query: 243 ES-----LSSYISL 251
            +     L   + +
Sbjct: 566 TNPGKQTLEVAVKV 579


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 33/205 (16%), Positives = 68/205 (33%), Gaps = 43/205 (20%)

Query: 63  EDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES 122
           ++ +    +    G    + +   A +   W +  L RE+   LL       G FL+RE+
Sbjct: 456 KNDEAKEAEKIRDGFGKVLNNNGKALIDEEWFHGVLPREEVVRLLRHE----GDFLVRET 511

Query: 123 QTRRGCY-SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADG 181
                C   LSV      +W   +H+ +Q    G        +FP++  L+ +  +   G
Sbjct: 512 TRNDECQTVLSV------AWGGHKHFIVQTNLEGHFRF-EGPSFPTIQELILY--QYQSG 562

Query: 182 ICCP------LREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEAS 235
           +         L++P + +                      W+  +  +  L+    G   
Sbjct: 563 LPVTSRSGAILKKPILREV---------------------WELNNDDVQLLDKIGRGNFG 601

Query: 236 LLSEGLRESLS--SYISLAEDPLDD 258
            + +   +S +    +      L D
Sbjct: 602 DVYKAKLKSTNQEVAVKTCRVALPD 626


>UniRef50_P43405 Tyrosine-protein kinase SYK n=41 Tax=Euteleostomi RepID=KSYK_HUMAN
          Length = 635

 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 37/129 (28%), Positives = 54/129 (41%), Gaps = 7/129 (5%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
                W +  +SRE++E+++L+     G FLIR      G Y+L +         ++ HY
Sbjct: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLL-----HEGKVLHY 216

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPV 207
           RI +   G L I     F +L  LVEHYS  ADG+   L  PC  +            P 
Sbjct: 217 RIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC-QKIGTQGNVNFGGRPQ 275

Query: 208 TVPTSSLNW 216
              +    W
Sbjct: 276 LPGSHPATW 284



 Score = 96.3 bits (238), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 36/133 (27%), Positives = 60/133 (45%), Gaps = 13/133 (9%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               + +  ++RE+AE+ L+  G   G +L+R+S+   G ++LSV   R A      HY 
Sbjct: 11  NHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAH-----HYT 65

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVT 208
           I+R  NG   I+   T  S   L  ++S+ +DG+ C L++P    +           P T
Sbjct: 66  IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQ--------PKT 117

Query: 209 VPTSSLNWKKLDR 221
            P   L    +  
Sbjct: 118 GPFEDLKENLIRE 130


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  107 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 32/186 (17%), Positives = 58/186 (31%), Gaps = 44/186 (23%)

Query: 83   SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTR-RGCYSLSVRLSRPASW 141
            S         W +  L RE+   LL       G FL+RE+         LSV       W
Sbjct: 941  STNRPLHEEEWFHGVLPREEVVRLLRNE----GDFLVRETTRNDESQTVLSVC------W 990

Query: 142  DRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCP------LREPCVLQKL 195
            +  +H+ +Q    G         FPS+  L+ H  +    +         LR+P + ++ 
Sbjct: 991  NGHKHFIVQTTAEGHYRF-EGPAFPSIQELIVH--QYQSELPVTGRSGAVLRKPVLRER- 1046

Query: 196  GPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS---SYISLA 252
                                W+  +  ++ L+    G    + +   +S       +   
Sbjct: 1047 --------------------WELSNDDVILLDKIGRGNFGDVYKAKLKSSKNTLVAVKTC 1086

Query: 253  EDPLDD 258
               L +
Sbjct: 1087 RMTLPE 1092


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score =  107 bits (266), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 30/188 (15%), Positives = 54/188 (28%), Gaps = 30/188 (15%)

Query: 72  SEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
              +G    +P          W Y  + R++AEE         G +LIR S +++  Y L
Sbjct: 506 ESETGSTTDVP-PETRVEEERWFYPNMERKEAEE----KCKNTGDYLIRYS-SKQNRYVL 559

Query: 132 SVRLSRPASWDRIRHYRIQRLDNGW---LYISPRLTFPSLHALVEHYSELADGICCPLRE 188
           +V         + +H+ IQ   +      Y     +FPS+  L++ +           + 
Sbjct: 560 TV-----CWAGQGKHFVIQEAPDEQTKTKYRFESRSFPSVRELLDFHVNS--------QT 606

Query: 189 PCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE-GLRESLSS 247
           P        L                 W      +        G    + E  L+     
Sbjct: 607 PVTKASGAILSRPIL-------REDDKWALKHEDIKMGRKLGKGAFGDVWEAALKGQGKV 659

Query: 248 YISLAEDP 255
            +      
Sbjct: 660 AVKTCRST 667


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score =  106 bits (265), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 41/195 (21%), Positives = 71/195 (36%), Gaps = 26/195 (13%)

Query: 56  EPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS--REKAEELLLLPG-N 112
           +   + S++ +    +S  +  +           +  W +  L   R KAE+LL      
Sbjct: 525 DETAVTSQEDE--EEESNDTSLQLEGLGNDEMHFSEKWFHGKLEGGRRKAEDLLKEYSYL 582

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTFPSLH 169
             G FL+RES T  G +SLS           + H RI+ + + G    Y+   L F SL+
Sbjct: 583 GDGTFLVRESDTFVGDFSLSFWRKDS-----VNHCRIRSKQERGQTKYYLIDNLAFDSLY 637

Query: 170 ALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTV---PTSSLNWKKLDRSLLFL 226
           +L+ HY           + P   Q    +  +  P P +    P       +     +  
Sbjct: 638 SLITHYQ----------KYPLRSQDFQQILKEPVPQPQSHHGKPWYHEKLDRTRAEDMLK 687

Query: 227 EAPASGEASLLSEGL 241
             P+ G   +   G+
Sbjct: 688 RIPSDGAFLVRQNGV 702



 Score = 85.9 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 32/147 (21%), Positives = 59/147 (40%), Gaps = 12/147 (8%)

Query: 48  ARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVA-HGWLYEGLSREKAEEL 106
             L+    + L  +      + ++S+   +    P           W +E L R +AE++
Sbjct: 629 DNLAF---DSLYSLITHYQKYPLRSQDFQQILKEPVPQPQSHHGKPWYHEKLDRTRAEDM 685

Query: 107 LLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFP 166
           L       GAFL+R++      Y++S R     +  +I+H  I++   G L+      F 
Sbjct: 686 LKRIP-SDGAFLVRQNGVDTNSYAISFR-----AEGKIKHCIIKQ--EGRLFTIGNAQFE 737

Query: 167 SLHALVEHYSELADGICCPLREPCVLQ 193
           SL  LV +Y +        L+ P   +
Sbjct: 738 SLVELVNYYEKKPLYRKMKLKHPVNEK 764



 Score = 54.0 bits (128), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 15/77 (19%), Positives = 28/77 (36%), Gaps = 3/77 (3%)

Query: 16  SSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVS 75
              G    P    P+ H     AL  + A  +  LS      +T + +  + W +    +
Sbjct: 780 GGPGIYMNPNDFTPKIH---VRALYDYRAQMEDELSFCKNAIITNVIKRDEGWWLGDPGN 836

Query: 76  GREYHMPSVYVAKVAHG 92
            +  + PS YV ++   
Sbjct: 837 QKRLYFPSNYVEEIRSQ 853


>UniRef50_O77440 Protein-tyrosine kinase HTK98 n=3 Tax=Eumetazoa RepID=O77440_HYDAT
          Length = 624

 Score =  106 bits (265), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 44/295 (14%), Positives = 84/295 (28%), Gaps = 96/295 (32%)

Query: 42  FPAGEQARLSLRLGEPLT-IISEDGDWWTVQSEVSGREYHMPSVYVA----KVAHGWLYE 96
           +       L     E +  ++  +G    V +E + R++ +   YV          W + 
Sbjct: 113 YKGISHDDL----DEAIRTVLRTEG----VVNEEAVRKFKVKMEYVVGNILHRQQPWFHG 164

Query: 97  GLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGW 156
            + R +AE  L       G FLIRE  + RG Y + +          + HY  +  + G 
Sbjct: 165 VIPRTEAERRLKSLS-ETGMFLIRERGSPRGSYVIGLFYQ-----GGVYHYLFESNNQGQ 218

Query: 157 LYISPRLTFPSLHALVEHYSELADGICCP----------------------LREP----- 189
           L I    +F +L A+V  YS+ ++G+ C                       L  P     
Sbjct: 219 LSIKSGRSFDNLMAVVNFYSQKSEGLFCTLKRACEVSWFEFQPKTEIYKNILLHPEIQAE 278

Query: 190 -----------------CVLQKLGPLPGKDTPPPVTVPTSSLNW---------------- 216
                                +  P+P +              W                
Sbjct: 279 LKKTLLLYEDELKKYRRVSRVERPPVPNRPVSRVSNQIDVKDTWVYEKIYDSKDIVKKEG 338

Query: 217 ------------KKLDRSLLFLEAPASGEASLLSEGLR-----ESLSSYISLAED 254
                       +   + L        G    + +G+      +S++  +   ++
Sbjct: 339 FKNPFETQERETELDPKRLRLEHELGHGNFGSVVKGVYLLKNNKSVAVAVKTLKE 393



 Score = 99.8 bits (247), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 6/102 (5%)

Query: 93  WLYEGLSREKAEELLLLP-GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  ++R+ AE  L        G +L+RES +  G Y LSV         ++ HY IQR
Sbjct: 9   WFHGRITRDIAENCLQTTTSMDDGTYLLRESASEIGSYVLSV-----CKDKKVIHYAIQR 63

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
             +G + I+    FP    LV H+     G+   L  PC   
Sbjct: 64  QPSGMVGIADGPQFPGPVELVNHHKTSLGGLMTKLTYPCERP 105


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  106 bits (265), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 35/186 (18%), Positives = 64/186 (34%), Gaps = 31/186 (16%)

Query: 80  HMPSVYVAKV----AHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRL 135
           H PS             + +  L R++ E LL+      G F++RE     G Y LS + 
Sbjct: 190 HEPSNNQPTELRLEEEEFYHGALPRKETEALLV----NDGDFVVREKSDAWGRYVLSAKH 245

Query: 136 SRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKL 195
           +      ++RH+ IQ  D     +     F ++  L+      +       R+P      
Sbjct: 246 AS-----KVRHFPIQINDENMYRL-EGDAFQTVGELIRF-QLNS-------RQPVTKASQ 291

Query: 196 GPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL--RESLSSYISLAE 253
             L       PV    +  + +     +   E   +G    +  G   R  L+  +   +
Sbjct: 292 AILLK-----PVCRVRNEHDLR--HEEIDLEEKLGAGHFGDVHRGRIKRTQLAVAVKTCK 344

Query: 254 DPLDDA 259
           + +D A
Sbjct: 345 ETVDAA 350


>UniRef50_UPI000186F028 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186F028
          Length = 378

 Score =  106 bits (264), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 37/130 (28%), Positives = 53/130 (40%), Gaps = 2/130 (1%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE   E+L     P GAF++RES ++ GCY+LS+R+ R      I HY I R
Sbjct: 244 PWFQAGIPREITLEVLGQE--PVGAFMVRESTSKPGCYALSLRVPRDFQPSGIAHYLIMR 301

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
              G+        F +L AL+ H+S + + + CPL                  P      
Sbjct: 302 TMKGYKIKGFTKEFTTLTALITHHSVMPELLPCPLSLSRFNASFTQTDSNRDFPDTDSDP 361

Query: 212 SSLNWKKLDR 221
                    R
Sbjct: 362 DYDTLADFRR 371


>UniRef50_C3YUH5 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YUH5_BRAFL
          Length = 302

 Score =  105 bits (263), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 28/133 (21%), Positives = 52/133 (39%), Gaps = 15/133 (11%)

Query: 124 TRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGIC 183
           +    Y++SV  S     +R+ H+++QR   G LY+   L F SL  L+EHY        
Sbjct: 5   SGSHLYTISVLHS-KTGNNRVNHFKVQRFTEGKLYVEAGLEFDSLTELLEHYLREGQIRS 63

Query: 184 CPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEG-LR 242
           C +  PC   ++     +              W+    ++  L+    G    + +G  +
Sbjct: 64  CTISTPCPKSEVPQPHAEI-------------WEISRDNIKLLKKIGQGNFGDVFQGRWK 110

Query: 243 ESLSSYISLAEDP 255
           E+    +  A+  
Sbjct: 111 ETNDVAVKTAKKG 123


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score =  105 bits (263), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 28/182 (15%), Positives = 53/182 (29%), Gaps = 32/182 (17%)

Query: 75  SGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRES-QTRRGCYSLSV 133
           +G +  +    V      W +  L RE+   LL+      G +L+RE+ +       LSV
Sbjct: 296 NGEQMSVNPN-VVLQDEDWFHGVLPREEVVRLLV----NNGDYLVRETMRNEEKQVVLSV 350

Query: 134 RLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
                      +H+ +Q   +G         F ++  L+  Y          L  P   +
Sbjct: 351 CWQGH------KHFIVQTTSDGKYRF-EGPAFGTVQELIV-YQHH-------LGLPVTSK 395

Query: 194 KLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISL 251
               L           P     W+  +  +  +E    G    +   +         +  
Sbjct: 396 SGAIL---------QNPIFRERWELNNDDVELVEKIGRGNFGDVYRAVLHPQRTEVAVKT 446

Query: 252 AE 253
             
Sbjct: 447 CR 448


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =  105 bits (263), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 39/179 (21%), Positives = 61/179 (34%), Gaps = 31/179 (17%)

Query: 80  HMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
            +P V        W +  + R +  ELL+      G FL+RESQ +   Y LSV      
Sbjct: 389 LIPEVQKPLHEQLWYHGAIPRAEVAELLVHS----GDFLVRESQGK-QEYVLSVL----- 438

Query: 140 SWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLP 199
                RH+ IQ LDN +        FPS+  L++H       +          +K G + 
Sbjct: 439 WDGLPRHFIIQSLDNLYRLEGEG--FPSIPLLIDHLLSTQQPL---------TKKSGVVL 487

Query: 200 GKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAEDPL 256
            +  P           W      L+  E    G    +  G   + +    +    + L
Sbjct: 488 HRAVPK--------DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETL 538


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score =  105 bits (263), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 30/164 (18%), Positives = 53/164 (32%), Gaps = 31/164 (18%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTR-RGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  L RE+   LL       G FL+RE+         LSV       W   +H+ +Q 
Sbjct: 537 WFHGVLPREEVVRLLTKE----GDFLVRETTRNDENQTVLSVC------WGGHKHFIVQT 586

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPT 211
              G        +FP++  L+ +  +    +      P   +    L           P 
Sbjct: 587 TSEGEFRF-EGPSFPTIQELITY--QYQSAL------PVTSRSGAIL---------RQPI 628

Query: 212 SSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAE 253
               W+  +  +L LE    G    + +    S +  + +    
Sbjct: 629 PRERWELNNDDVLLLEKIGRGNFGDVYKARLRSTNKEAAVKTCR 672


>UniRef50_UPI0000D555ED PREDICTED: similar to CG33993 CG33993-PA n=2 Tax=Endopterygota
           RepID=UPI0000D555ED
          Length = 562

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/95 (35%), Positives = 53/95 (55%), Gaps = 2/95 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE A E+L     P GAF++RES ++ GC++LS+R+ R      I HY I R
Sbjct: 428 PWFQAGIPREIALEILAQE--PVGAFMVRESTSKPGCFALSLRVPRSFQPTGIAHYLIVR 485

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
            + G+        F +L +L+ H+S + + + CPL
Sbjct: 486 TNKGYKIKGFTKEFTTLTSLITHHSVMPELLPCPL 520


>UniRef50_UPI000155BA92 PREDICTED: similar to Fyn-related kinase, partial n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BA92
          Length = 186

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 38/119 (31%), Positives = 55/119 (46%), Gaps = 12/119 (10%)

Query: 26  SMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISED-GDWWTVQSEVSG-------R 77
           S    R     VAL  + A     LS   G+ L ++      WW  +    G        
Sbjct: 68  SRSSPRPAGIFVALFDYRARTAEDLSFVAGDRLQVLDASHPGWWLARLLGHGGDDPGQQS 127

Query: 78  EYHMPSVYVAKVA----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           + ++P+ Y+AK        W +  + R  AE+ LL  GN  GAFLIRES++++G YSLS
Sbjct: 128 QGYVPANYLAKDQSLQAEQWFFGAIKRVDAEKQLLYSGNRPGAFLIRESESQKGDYSLS 186


>UniRef50_UPI00015B5EF2 PREDICTED: similar to ENSANGP00000021630 n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B5EF2
          Length = 389

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 2/95 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE   E+L     P GAF++RES ++ GCY+LS+R+ R      I HY I R
Sbjct: 255 PWFQAGIPREITLEVLSQE--PEGAFMVRESTSKPGCYALSLRVPREFQPSGIAHYLIMR 312

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
            + G+        F +L AL+ H+S + + + CPL
Sbjct: 313 TNKGYKIKGFTKEFTTLTALITHHSVMPELLPCPL 347


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 11/101 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  LS ++AE L+L  G   G+FL+RESQ++ G + LSVR     + D++ H  I+  
Sbjct: 58  WFHGNLSGKEAERLILERGK-NGSFLVRESQSKPGDFVLSVR-----TEDKVTHVMIRWH 111

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELA----DGICCPLREP 189
           +N    +     F +L  L+EHY         G    LR+P
Sbjct: 112 EN-KYDVGGGQKFGTLCELIEHYKRNPMVEICGTVVHLRQP 151


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 42/180 (23%), Positives = 69/180 (38%), Gaps = 18/180 (10%)

Query: 84  VYVAKVAHGWLYEGL--SREKAEELLLLPGN-PGGAFLIRESQTRRGCYSLSVRLSRPAS 140
                 +  W +  L   R +AE LL    +   G FL+RES+T  G YSLS        
Sbjct: 586 NDELHFSEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRESETFVGDYSLSFWRQ---- 641

Query: 141 WDRIRHYRIQ-RLDNG--WLYISPRLTFPSLHALVEHYSELAD---GICCPLREPCVLQK 194
             ++ H RI+ + D G    Y+    +F SL++L+ +Y             L+EP   Q 
Sbjct: 642 -GKVNHCRIRSKQDKGQTKYYLIDTNSFDSLYSLITYYRSHPLRSQEFLIVLKEPVP-QP 699

Query: 195 LGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAP---ASGEASLLSEGLRESLSSYISL 251
                 +   P VT   +    K++     FL  P    +   ++     ++     I +
Sbjct: 700 NKHEGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRPSERGANSYAISFRAEKKIKHCRIKV 759



 Score = 89.8 bits (221), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 32/121 (26%), Positives = 50/121 (41%), Gaps = 9/121 (7%)

Query: 71  QSEVSGREYHMPSVYVAKVA-HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY 129
           +S+        P     K     W    ++R +AEE+L       GAFL+R S+     Y
Sbjct: 684 RSQEFLIVLKEPVPQPNKHEGKEWYLPNVTRSQAEEMLKRVPT-DGAFLVRPSERGANSY 742

Query: 130 SLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           ++S R     +  +I+H RI+   +G LY    + F SL  L+ +Y          L  P
Sbjct: 743 AISFR-----AEKKIKHCRIKV--DGRLYAIGSVYFESLVDLITYYERHPLYKKIRLCHP 795

Query: 190 C 190
            
Sbjct: 796 V 796



 Score = 57.8 bits (138), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 14/77 (18%), Positives = 28/77 (36%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYV 86
                 K+T  A+  + A ++  LS      +T +++    W        +++  P  YV
Sbjct: 822 PSSFTSKITVKAIYDYQARQEDELSFCKHAIITNVNKQDRGWWRGDYGGKKQHWFPCNYV 881

Query: 87  AKVAHGWLYEGLSREKA 103
            ++      E   RE  
Sbjct: 882 EEIEPQENREDTVRENM 898


>UniRef50_A4F2N7 Mt-tensin-b (Fragment) n=2 Tax=Molgula tectiformis RepID=A4F2N7_9ASCI
          Length = 1177

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 37/150 (24%), Positives = 64/150 (42%), Gaps = 16/150 (10%)

Query: 82   PSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLS----- 136
            P ++V  V + W    ++RE+A ++L     P G+F++R+S+   G Y L++++      
Sbjct: 887  PPLFVHDVQNLWYKPDITREQALDMLRH--RPAGSFVVRDSRCFPGAYGLALKVDKLPSN 944

Query: 137  ------RPASWDRIRHYRIQRLDNGWLYIS--PRLTFPSLHALVEHYSELADGICCPLRE 188
                       + +RH+ I+    G           F SL ALV  +S     + C L  
Sbjct: 945  VRPQAGADIQNELVRHFLIEPSSRGVKLKGCKNEPVFGSLPALVYQHSITPLALPCRLII 1004

Query: 189  PCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
            P  +    P PG    P   VP S+ +  +
Sbjct: 1005 P-KIDPATPPPGTLPRPGTEVPNSATDLLR 1033


>UniRef50_A7T8K3 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T8K3_NEMVE
          Length = 402

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 32/129 (24%), Positives = 56/129 (43%), Gaps = 6/129 (4%)

Query: 63  EDGDWWT----VQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
           ++  W+       +  + +      +        W   G+ RE   E+L       G+F 
Sbjct: 236 QNECWYKPGIPRMNISTCQALQGMYIVYDYQNECWYMPGIPREFIMEMLQAS--EEGSFF 293

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSEL 178
           +R+SQ++ GC++L+VR+          +Y I  +  G        TF  L +L+E+YS  
Sbjct: 294 VRDSQSKPGCHALTVRVPTEVHASGFGNYLITPIPEGVKLEGFSRTFTDLVSLIEYYSYH 353

Query: 179 ADGICCPLR 187
           ADG+ C L 
Sbjct: 354 ADGLPCRLL 362


>UniRef50_C4Q5Y9 Tensin-related n=1 Tax=Schistosoma mansoni RepID=C4Q5Y9_SCHMA
          Length = 1117

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 39/118 (33%), Positives = 54/118 (45%), Gaps = 2/118 (1%)

Query: 72  SEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
           S+  G          +     W    L RE A ELL       G+FL+R S T  GC +L
Sbjct: 770 SQFQGCNKIASDSDNSLNQAPWFQAMLPREIAFELL--AKEEVGSFLVRNSATHPGCCAL 827

Query: 132 SVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREP 189
           SVR+    +   I HY IQ+ + G         +PSL ALV H + + + + CPL+ P
Sbjct: 828 SVRVPNKDNPIGITHYLIQKTNRGVRLKGLDKEWPSLQALVTHLTVIPEMLPCPLKLP 885


>UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schistosoma mansoni
           RepID=Q7YSY1_SCHMA
          Length = 1259

 Score =  104 bits (259), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 31/218 (14%), Positives = 61/218 (27%), Gaps = 56/218 (25%)

Query: 69  TVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRE-SQTRRG 127
               + +      P   +      W +  L R + E LL       G FL+R+ S+   G
Sbjct: 797 RESQDSTSILTSFPICDMDINKEPWFHGVLPRAEVERLLQNQ----GDFLVRQTSKRSSG 852

Query: 128 CYSL-----------------------------SVRLSRPASWDRIRHYRI---QRLDNG 155
             ++                              +R+     W   RH+ +        G
Sbjct: 853 RDTIGHWNGTNGDLINGNHNETILNKDHNMDGTVLRMVLSVFWHGHRHFILYGGPETGEG 912

Query: 156 WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLN 215
           W        F ++  L+E++ +         + P   +    L           P S  +
Sbjct: 913 WHLEDGH--FSTIRELIEYHMKT--------QTPVTAKSGACLVT---------PISRPD 953

Query: 216 WKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLAE 253
           W+  +R +  L+    G    +  G+       +    
Sbjct: 954 WELDNRDVQLLQKIGQGNFGDVYRGVYNGCEVAVKTCR 991


>UniRef50_Q63HR2 Tensin-like C1 domain-containing phosphatase n=29 Tax=Euteleostomi
            RepID=TENC1_HUMAN
          Length = 1409

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 36/231 (15%)

Query: 3    SLSSRGKTSSPSPSS---SGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLT 59
            S  + G +  P P      GP Q+P    PE+    A  +                    
Sbjct: 1062 SYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAP------------ 1109

Query: 60   IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLI 119
            ++S++        E   +E      +V   +  W    LSR++A  LL       GAFLI
Sbjct: 1110 LLSDNVPQ---TPEPPTQESQSNVKFVQDTSKFWYKPHLSRDQAIALL--KDKDPGAFLI 1164

Query: 120  RESQTRRGCYSLSVRL----------SRPASWDRIRHYRIQRLDNGWLYIS--PRLTFPS 167
            R+S + +G Y L++++                  +RH+ I+    G           F S
Sbjct: 1165 RDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIETGPKGVKIKGCPSEPYFGS 1224

Query: 168  LHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKK 218
            L ALV  +S     + C LR P       PL      P  T  +++ +  +
Sbjct: 1225 LSALVSQHSISPISLPCCLRIP----SKDPLEETPEAPVPTNMSTAADLLR 1271


>UniRef50_Q7Q480 AGAP008273-PA (Fragment) n=3 Tax=Culicidae RepID=Q7Q480_ANOGA
          Length = 291

 Score =  104 bits (258), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 36/124 (29%), Positives = 55/124 (44%), Gaps = 3/124 (2%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   GL RE + E+L       GAFL+R S T+ GC++LS+R+  P S  ++ HY I + 
Sbjct: 163 WFQAGLPRELSLEVLTQQS--PGAFLVRRSTTKHGCFALSLRVP-PGSGPKVVHYLIMKT 219

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTS 212
           + G+        F SL AL+ H+S + + +  PL  P            D     +    
Sbjct: 220 ERGYKIKGFTKEFSSLRALITHHSVMPEMLPVPLSLPRPQNIPTKCKHTDDYDTFSALNE 279

Query: 213 SLNW 216
               
Sbjct: 280 FSKL 283


>UniRef50_Q380D8 AGAP001259-PA (Fragment) n=3 Tax=Culicidae RepID=Q380D8_ANOGA
          Length = 264

 Score =  104 bits (258), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 37/115 (32%), Positives = 56/115 (48%), Gaps = 4/115 (3%)

Query: 78  EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
           +      Y   +   W +E L R  + +LL       G+FL+R+S T+  CY+LS+R+  
Sbjct: 127 DLEQEREYRRLLDECWYHENLPRSLSLQLL--ADKLPGSFLVRKSTTQPDCYALSLRVP- 183

Query: 138 PASWDRIRHYRIQRL-DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
           P S  RI HY I R    G+     +  F SL AL+ H+S + + +  PL  P  
Sbjct: 184 PGSGPRIAHYLIVRTSTEGYKIKGFQKEFSSLRALIVHHSVMPEALPVPLAVPRP 238


>UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925DBE
          Length = 249

 Score =  103 bits (257), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 39/197 (19%), Positives = 68/197 (34%), Gaps = 11/197 (5%)

Query: 51  SLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLP 110
           +L LG+ +  I  D    + +        +  S         W +  ++R  +E LLL  
Sbjct: 12  TLNLGDSIDEIENDQFLSSDEDADDSELLYWKSCANYIEDLPWFHGDMTRNTSEALLLAN 71

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHA 170
           G   G +L+R S +  G Y++SVR         I+HY ++   +   Y   R  + S + 
Sbjct: 72  GVE-GTYLVRNSASDPGSYTVSVRCQSS-----IKHYSLRHNVHDNTYTFGRGFYDSYND 125

Query: 171 LVEHYSELA-----DGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLF 225
           L++H+          G     R P +     P   +            +N+    + L  
Sbjct: 126 LIDHFECKPVLTGETGEPVIFRYPYIKDVPEPSSYEKVLRHAEEGKEEINYTINIQELTD 185

Query: 226 LEAPASGEASLLSEGLR 242
                     L    LR
Sbjct: 186 YHNWKKRWFVLHKNILR 202


>UniRef50_P34265 Probable tyrosine-protein kinase kin-31 n=4 Tax=Caenorhabditis
           RepID=KIN31_CAEEL
          Length = 437

 Score =  103 bits (257), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 26/183 (14%), Positives = 65/183 (35%), Gaps = 38/183 (20%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGC---YSLSVRLSRPA 139
           +         + +  + RE   +LL    +  G +++R S  + G    Y LSV  +   
Sbjct: 10  TPTPTIEKEAYFHGLIQREDVFQLL----DNNGDYVVRLSDPKPGEPRSYILSVMFNNKL 65

Query: 140 SWDR-IRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGI--CCPLREPCVLQKLG 196
             +  ++H+ I  ++N   +++  ++F ++  ++ HY +    I   C +  P   Q   
Sbjct: 66  DENSSVKHFVINSVEN-KYFVNNNMSFNTIQQMLSHYQKSRTEILEACKILHPVRRQF-- 122

Query: 197 PLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE------SLSSYIS 250
                              W+    +++  +    G    +S G+ +       +   + 
Sbjct: 123 -------------------WELDHGNIVIEKKLGEGAFGEVSSGVMKFKRGGRLVKVAVK 163

Query: 251 LAE 253
             +
Sbjct: 164 QVK 166


>UniRef50_Q9VRS2 CG32406 n=13 Tax=Drosophila RepID=Q9VRS2_DROME
          Length = 474

 Score =  103 bits (256), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 3/101 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+SR+ A E+L       GAFL+R+S ++ GCY+L++R+  P    +I +Y I R
Sbjct: 341 CWYQAGISRDIAVEVL--QSKSPGAFLVRKSSSKPGCYALTLRVPSPP-GPKIANYIILR 397

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVL 192
              G+     R  F SL AL+ H+S + + +  PL  P   
Sbjct: 398 SPRGYKIKGFRKEFSSLKALITHHSVMPELLPVPLAMPRPT 438


>UniRef50_C4WY34 ACYPI003382 protein n=3 Tax=Neoptera RepID=C4WY34_ACYPI
          Length = 214

 Score =  103 bits (256), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 41/169 (24%), Positives = 61/169 (36%), Gaps = 9/169 (5%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYV 86
             P     + VA+  F +G   R+     E L I   +          SGR        V
Sbjct: 36  PLPNESVRSHVAM-DF-SGNVGRIVEDPKEALAIAQAETGSVRRSWRSSGRTTPGLQAAV 93

Query: 87  A------KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPAS 140
                   ++  W ++ +SR++A  +L   GN  G FLIRES+++ G Y LS +      
Sbjct: 94  TKLENDIHLSQPWYHKNMSRDQAANVLHALGNKDGVFLIRESKSKCGSYVLSFKCGGKII 153

Query: 141 WDRIRHYRIQRLDNGWLYISPRL-TFPSLHALVEHYSELADGICCPLRE 188
              I        D     +   +  F  L  LVE Y   A  +   L  
Sbjct: 154 HTPIVTQMDPLNDQVCFTLDNGVIKFYDLLQLVEFYQLNAGSLPTRLMH 202


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score =  102 bits (255), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 37/166 (22%), Positives = 66/166 (39%), Gaps = 18/166 (10%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  +S  +AE+LL   G   G+FL R S +  G ++LSVR       + + H 
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGF-DGSFLARLSSSNPGAFTLSVR-----RGNEVTHI 54

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSEL-----ADGICCPLREPCVLQKLGPLPGKD 202
           +IQ   + +  +     F +L  LV++Y E       +G    L++P +  +     G  
Sbjct: 55  KIQNNGD-FFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERGHY 113

Query: 203 TPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSY 248
               + +PT+      +       +     +A   S GL      Y
Sbjct: 114 KEATLDIPTA------IPAHDQLCKTGGDRQAPNPSAGLYTGHRVY 153


>UniRef50_A7RU23 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RU23_NEMVE
          Length = 814

 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 2/101 (1%)

Query: 87  AKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRH 146
                 W   G+ RE   E+L       G+F +R+SQ++ GC++L+VR+          +
Sbjct: 676 DYQNEYWYMPGIPREFIMEMLQAS--EEGSFFVRDSQSKPGCHALTVRVPTEVHASGFGN 733

Query: 147 YRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
           Y I  +  G        TF  L +L+E+YS  ADG+ C L 
Sbjct: 734 YLITPIPEGVKLEGFSRTFTDLVSLIEYYSYHADGLPCRLL 774


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 45/212 (21%), Positives = 76/212 (35%), Gaps = 34/212 (16%)

Query: 8   GKTSSPSPSSSGPDQEPVSMQPERHKVTAVALG------------SFPAGEQARLSLRLG 55
           G+T    P  + PD  P     E++ V A +              +F A +  + +L   
Sbjct: 120 GETDYSDPFDARPDPRPRPGW-EQNAVEACSSYMEPFEAQRFINVTFEAADWDQCTLPCD 178

Query: 56  EPLT-----IISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLP 110
           E L       +S      T   +  G         +      W +  L+R +AE LL L 
Sbjct: 179 EALRKAGVSRVSPPSSGATSLRKPHGILGERVDPMLPLEKQVWYHGALTRSEAESLLTLC 238

Query: 111 GNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISP-RLTFPSLH 169
                ++L+R+SQT R  YSLS+R           H +  +  +G   +      F S+ 
Sbjct: 239 KEC--SYLVRKSQTSRNDYSLSLRSCH-----GFMHMKFSQSRDGKFILGENSPPFDSIP 291

Query: 170 ALVEHYSELADGICCP------LREPCVLQKL 195
            ++  Y+     +         L  P ++Q L
Sbjct: 292 EVIHFYTTNK--LPIRGAEHLSLLFPVLVQTL 321


>UniRef50_UPI000194DBC6 PREDICTED: similar to tensin 4 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DBC6
          Length = 731

 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 12/147 (8%)

Query: 72  SEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
           S+   +       +V   +  W    +SR++A +LL       G FL+R+S + RG + L
Sbjct: 449 SDSPLKAGQPTMKFVMDTSKYWFKPSISRDRAIQLLR--DKEPGTFLVRDSTSFRGSFGL 506

Query: 132 SVRLSRPASW--------DRIRHYRIQRLDNGWLYIS--PRLTFPSLHALVEHYSELADG 181
           ++++    S         D +RH+ I+    G         L F SL A V  +S     
Sbjct: 507 AMKVPGSPSGSQTGEESSDLVRHFLIESSTKGVHLXGASEELYFGSLSAFVYQHSITPLA 566

Query: 182 ICCPLREPCVLQKLGPLPGKDTPPPVT 208
           + C L  P      G      TP P  
Sbjct: 567 LPCKLSIPTRDLADGEDSPDCTPEPAL 593


>UniRef50_UPI000155BC71 PREDICTED: similar to inositol polyphosphate 5- phosphatase n=1
           Tax=Ornithorhynchus anatinus RepID=UPI000155BC71
          Length = 1019

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 38/158 (24%), Positives = 65/158 (41%), Gaps = 11/158 (6%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
           + H W +  ++R KAEELL   G   G+FL+R S++    Y+L V        + +  YR
Sbjct: 1   MVHCWNHGNITRSKAEELLSKTGK-DGSFLVRASESISRAYALCVLY-----HNCVYTYR 54

Query: 149 IQRLDNGWLYIS-----PRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           I   D+    +      P   F SL  L++ Y +   G+   L+ P  L++       + 
Sbjct: 55  ILPNDDEKFTVQASEGVPMRFFTSLEQLIDFYKKENMGLVTHLQYPVQLEEEDAADDPEE 114

Query: 204 PPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGL 241
                +    L  + +    +  E   +  AS  S G+
Sbjct: 115 ETEFIMSPPELPPRNIPLPAVLSETKETVLASDSSRGV 152


>UniRef50_A7URX1 AGAP006893-PA n=3 Tax=Culicidae RepID=A7URX1_ANOGA
          Length = 374

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 35/102 (34%), Positives = 53/102 (51%), Gaps = 4/102 (3%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE + E+L       GAFL+R+S T+ GC++LS+R+  P    ++ HY I R
Sbjct: 254 PWFQAGIPREISLEVLSRQ--NPGAFLVRQSTTKPGCFALSLRV--PPPAPKVAHYLILR 309

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQ 193
              G+        F SL AL+ H+S + + +  PL  P   Q
Sbjct: 310 TIRGYKIKGFTKEFTSLRALITHHSVMPELLPVPLALPRPPQ 351


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 38/172 (22%), Positives = 58/172 (33%), Gaps = 20/172 (11%)

Query: 72  SEVSGREYHMPSVYVAKVAHGWLYEGLS-----REKAEELLLLP----GNPGGAFLIRES 122
           +E       + S         W +  L      R  AE LL       G P G+FL+RES
Sbjct: 529 NEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRES 588

Query: 123 QTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTFPSLHALVEHYSELA 179
           +T  G Y+LS          +++H RI  R D G    +++  L F SL+ L+ HY ++ 
Sbjct: 589 ETFVGDYTLSFW-----RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVP 643

Query: 180 D---GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
                    L EP                        +  +        +  
Sbjct: 644 LRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRK 695



 Score = 85.9 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 28/116 (24%), Positives = 50/116 (43%), Gaps = 9/116 (7%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  L+R +AE +L+      GAFL+R+       Y++S R     +  +I+H 
Sbjct: 663 HESKEWYHASLTRAQAEHMLMRVPR-DGAFLVRKR-NEPNSYAISFR-----AEGKIKHC 715

Query: 148 RIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           R+Q+   G   +     F SL  L+ +Y +        LR P   + L  +   + 
Sbjct: 716 RVQQ--EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEP 769



 Score = 51.3 bits (121), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 13/77 (16%), Positives = 25/77 (32%), Gaps = 2/77 (2%)

Query: 16  SSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVS 75
            + G   E   M     K    AL  + A  +  L+      +  + +    W       
Sbjct: 778 RNPGFYVEANPMP--TFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGG 835

Query: 76  GREYHMPSVYVAKVAHG 92
            ++   PS YV ++ + 
Sbjct: 836 KKQLWFPSNYVEEMVNP 852


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 34/156 (21%), Positives = 60/156 (38%), Gaps = 15/156 (9%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
             +  W +  +SR++AE LL       G+FL+R S    G +SLS         +R++H 
Sbjct: 317 HFSEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRK-----NRVQHC 371

Query: 148 RI--QRLDNG--WLYISPRLTFPSLHALVEHYSELA---DGICCPLREPCVLQKLGPLPG 200
            I  +  ++G    ++     F +L++L+ HY       D     L EP   Q    L  
Sbjct: 372 HIKSRPTNDGTAKYFLVGPKGFDNLYSLINHYQTNPLKSDKFELMLTEPVP-QPNAHLGK 430

Query: 201 KDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASL 236
                 +T   +    +++ +   FL          
Sbjct: 431 DWYHENLTRLQAEEMLRRMRKDSYFLVR--KRNDGD 464



 Score = 82.9 bits (203), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 10/108 (9%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQT--RRGCYSLSVRLSRPASWDRIRHYR 148
             W +E L+R +AEE+L         FL+R+     +   Y++S R     +   I+H  
Sbjct: 430 KDWYHENLTRLQAEEMLRRM-RKDSYFLVRKRNDGDQNESYAISFR-----TGGTIKHCV 483

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG 196
           I++   G L++     F SL  L+ HY +        L+ PC    + 
Sbjct: 484 IKK--EGRLFMIGTAPFESLTELIAHYEKNPLYRKTKLKYPCNQDVVQ 529



 Score = 45.9 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 9/57 (15%), Positives = 17/57 (29%)

Query: 32  HKVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAK 88
            K    A   + A ++  LS   G  +  I +    W         +   P  +  +
Sbjct: 555 PKQACKAKYDYTAQKEDELSFTKGALIVNIMKYDGGWWRGDYNGHIQKWFPVNFTEE 611


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score =  101 bits (251), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 64/274 (23%), Positives = 97/274 (35%), Gaps = 57/274 (20%)

Query: 5   SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGE-------P 57
           SS+   S  + S+ G D E    +  R +       SF       LSLRL          
Sbjct: 552 SSKIYYSEETSSNQGNDDEEEHKEVRRPERK--KKSSFSRVLLTDLSLRLRPPTFPDRLV 609

Query: 58  LTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS-----REKAEELL----L 108
           L +++            +G + H+           W +  L      R+ AE LL    +
Sbjct: 610 LVLVNFQA--------SNGMDQHVT--------EKWFHGKLGAGRDGRQIAERLLSEYCM 653

Query: 109 LPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTF 165
             G P G+FL+RES+T  G Y+LS          R++H RI  R + G    Y++  L F
Sbjct: 654 ETGAPDGSFLVRESETFVGDYTLSFW-----RSGRVQHCRIHSRQEAGSPKFYLTDNLVF 708

Query: 166 PSLHALVEHYSELAD---GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRS 222
            +L AL+ HY ++A         L EP             T    +      N  +    
Sbjct: 709 DTLFALINHYQQVALRCNEFEMKLTEPVPQ----------TNAHESKEWYHANLSRSQAE 758

Query: 223 LLFLEAPASGEASLLSEGLRESLSSYISLAEDPL 256
            + +  P  G   +      E  S  IS   +  
Sbjct: 759 NMLMRVPRDGAFLVRKRA--EPNSFAISFRAEGK 790



 Score = 85.6 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 31/146 (21%), Positives = 56/146 (38%), Gaps = 9/146 (6%)

Query: 58  LTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAF 117
             +I+         +E   +         A  +  W +  LSR +AE +L+      GAF
Sbjct: 712 FALINHYQQVALRCNEFEMKLTEPVPQTNAHESKEWYHANLSRSQAENMLMRVPR-DGAF 770

Query: 118 LIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSE 177
           L+R+       +++S R     +  +I+H R+Q+   G   +     F SL  L+ +Y +
Sbjct: 771 LVRKRA-EPNSFAISFR-----AEGKIKHCRVQQ--EGQTVVLGTSEFDSLVDLISYYEK 822

Query: 178 LADGICCPLREPCVLQKLGPLPGKDT 203
                   LR P     L  +   + 
Sbjct: 823 HPLYRKMKLRYPINEDTLEKIGTAEP 848



 Score = 54.0 bits (128), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 10/59 (16%), Positives = 21/59 (35%)

Query: 33  KVTAVALGSFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAH 91
           K T  A+  + A     LS      +  + +    W        ++   P+ YV +++ 
Sbjct: 872 KCTVRAMYEYKAQRDDELSFTKNAIIYNVDKQEGGWWKGDCGGKKQLWFPANYVEEISP 930


>UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SVT4_TETNG
          Length = 1377

 Score =  100 bits (250), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 40/181 (22%), Positives = 60/181 (33%), Gaps = 19/181 (10%)

Query: 62  SEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLS-----REKAEELLLLP---GNP 113
            E   + T   E         +      A  W +  L      R+ AE+LL      G  
Sbjct: 539 EETSHYQTADEEEDDEVKEECNNNEQHCAERWFHGKLGGGRDGRQVAEKLLQEYCEGGAK 598

Query: 114 GGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ-RLDNG--WLYISPRLTFPSLHA 170
            G FL+RES+T  G Y+LS          R++H RI  R ++G    Y++  L F SL+ 
Sbjct: 599 DGTFLVRESETFVGDYTLSFW-----RSGRVQHCRIHSRQESGSTRFYLTDNLVFDSLYR 653

Query: 171 LVEHYSELAD---GICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE 227
           L+ HY +           L  P                   V    +  +        + 
Sbjct: 654 LICHYRDTPLRCNEFEMRLGNPVPQPNAHESREWYHSSLTRVQAEHMLMRVPRDGAFLVR 713

Query: 228 A 228
            
Sbjct: 714 K 714



 Score = 89.0 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 8/141 (5%)

Query: 72  SEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSL 131
           +E   R  +      A  +  W +  L+R +AE +L+      GAFL+R+  +    Y++
Sbjct: 666 NEFEMRLGNPVPQPNAHESREWYHSSLTRVQAEHMLMRVPR-DGAFLVRKR-SEHNSYAI 723

Query: 132 SVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCV 191
           S R     +  +I+H RIQ+ +     +     F SL  LV +Y +        LR P  
Sbjct: 724 SFR-----AEGKIKHCRIQQ-EGRLFMLGSSAEFESLMDLVSYYEKHPLYRKMKLRYPIN 777

Query: 192 LQKLGPLPGKDTPPPVTVPTS 212
              L  +    +  P     S
Sbjct: 778 EDTLDKMGTTVSRAPPERRRS 798



 Score = 55.9 bits (133), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 27/194 (13%), Positives = 53/194 (27%), Gaps = 31/194 (15%)

Query: 1   MGSLSSRGKTSSPSPSSSGPDQEPVSMQPERHK--------------------VTAVALG 40
           MG+  SR          S   + PV  + +                        T  AL 
Sbjct: 784 MGTTVSRAPPERRRSVESQMMKPPVPQELDYGALYEVRTPHFYVEANKMPTARCTVKALY 843

Query: 41  SFPAGEQARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSR 100
            + A  +  L       +  + +    W        ++   P+ YV +            
Sbjct: 844 DYRAQREDELCFSKQALILNVDKQEGGWWRGDYGGKKQLWFPANYVEE------LPSSPL 897

Query: 101 EKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYIS 160
            + +E +    +P G FL    +      S  V + +     R   + +         + 
Sbjct: 898 RELDEAVSSKNSPLGTFL----KGFLDVTSCHVVVHKDGKNSRPYVFTVHSQHFSSQPVQ 953

Query: 161 P-RLTFPSLHALVE 173
              ++  SL  L+ 
Sbjct: 954 SLDVSADSLEELIH 967


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score =  100 bits (250), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 21/148 (14%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGN 112
           ++ E L I +E  D ++++ + S                 W    + R +AEE+L   G 
Sbjct: 591 KINEWLGIKNEADDSYSLEEDESSP---------HHDESTWYVGDIKRSQAEEMLR--GT 639

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             G FLIRESQT++G Y+ SV +          H  + +   G+ +  P   + SL  LV
Sbjct: 640 CDGTFLIRESQTQKGSYACSVVVDGDTK-----HCVVYKTVTGYGFAEPYNLYSSLKDLV 694

Query: 173 EHYS-----ELADGICCPLREPCVLQKL 195
            HY      +  D +   L  P + +  
Sbjct: 695 LHYKNVSLVQHNDHLNVTLAHPVLARSQ 722



 Score = 87.5 bits (215), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 30/136 (22%), Positives = 48/136 (35%), Gaps = 14/136 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRE-SQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SRE+  E L     P G FL+R+ S    G Y+L++R        +I H     
Sbjct: 362 WYWGEISREEVNEKLR--DTPDGTFLVRDASSKLEGEYTLTLRKGGNNKLIKIYH----- 414

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADG-----ICCPLREPCVLQKLGPLPGKDTPPP 206
              G    S  LTF S+  L+ HY   +       +   L  P    +            
Sbjct: 415 -REGRYGFSEPLTFLSVVELINHYRHESLAQYNAKLDTKLLYPVSKYQQLVKENSIEEVG 473

Query: 207 VTVPTSSLNWKKLDRS 222
             +      +++  R 
Sbjct: 474 EQLKVYHDQYQEKSRE 489


>UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001927133
          Length = 521

 Score =  100 bits (249), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 40/202 (19%), Positives = 74/202 (36%), Gaps = 22/202 (10%)

Query: 6   SRGKTSSPSPSSSGPDQEPVSMQPERH----KVTAVALGSFPAGEQARLSLRLGEPLTII 61
           S      P P+ SGP       + +      K   V   + P     +  +   +     
Sbjct: 320 SMRPPLPPRPTISGPVNVSTVTRSQNDTVAIKRDVVKPTNRPPPAPEQPDVVKNQIRPAR 379

Query: 62  ---SEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
               E+   W  + E S +               W +  +SR +AE++L       G+FL
Sbjct: 380 PKNREEVSKWWKEIEYSRQAGL----DKEFNPLLWFHGIISRHEAEKILEKKDK--GSFL 433

Query: 119 IRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYIS-PRLTFPSLHALVEHYSE 177
           +R S+   G Y++S +        R +H+ I    NG+ +    ++   SL+ L++++  
Sbjct: 434 VRVSERVWG-YTVSFKDIA-----RCKHFLIDTSANGYQFFGTEQIVHNSLNELIDYHKI 487

Query: 178 LA-DGI-CCPLREPCVLQKLGP 197
               G+    L  PC  +   P
Sbjct: 488 NPISGLGQEILIYPCGQETNPP 509


>UniRef50_P52735 Guanine nucleotide exchange factor VAV2 n=43 Tax=Euteleostomi
           RepID=VAV2_HUMAN
          Length = 878

 Score =  100 bits (249), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 37/213 (17%), Positives = 74/213 (34%), Gaps = 52/213 (24%)

Query: 9   KTSSPSPSSSGPDQEPVSMQ-----PERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE 63
             +    S +GP  + V+MQ     P                    L+ + G+ L ++  
Sbjct: 576 SPADLDASGAGPGPKMVAMQNYHGNPAPPGKPV-------------LTFQTGDVLELLRG 622

Query: 64  DGD--WWTVQSEVSGREYHMPSVYVAKVA-------------------HGWLYEGLSREK 102
           D +  WW  +   + +  + PS  V                       + W    + R++
Sbjct: 623 DPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQ 682

Query: 103 AEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPR 162
            + LL    +  G +LIRE       +++S++ +      ++         + W++I+  
Sbjct: 683 TDNLL--KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVV------EKDNWIHITEA 734

Query: 163 LTFPSLHALVEHYSELADG-----ICCPLREPC 190
             F SL  LVE+Y   +       +   L+ P 
Sbjct: 735 KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPY 767



 Score = 52.0 bits (123), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 29/83 (34%), Positives = 37/83 (44%), Gaps = 5/83 (6%)

Query: 9   KTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRLGEPLTIISE---DG 65
                S +S GP     S+   R   TAVA  +F A +   LSLR G+ + I S    D 
Sbjct: 794 SPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQ 853

Query: 66  DWWTVQSEVSGREYHMPSVYVAK 88
            WW    E +GR    PS YV +
Sbjct: 854 GWWKG--ETNGRIGWFPSTYVEE 874


>UniRef50_B7QKA0 Putative uncharacterized protein n=1 Tax=Ixodes scapularis
           RepID=B7QKA0_IXOSC
          Length = 346

 Score =  100 bits (249), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 2/95 (2%)

Query: 92  GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
            W   G+ RE A E+L     P G+F++R+S ++ GC++LS+R+ R      I HY I  
Sbjct: 213 PWFQAGIPREIALEVLGQE--PVGSFMVRKSTSKPGCFALSLRVPRSLQPTGISHYLIMH 270

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADGICCPL 186
            + G+        F +L +L+ H+S + + + CPL
Sbjct: 271 TNRGYKIKGFTKEFGTLTSLITHHSVMPELLPCPL 305


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score =  100 bits (249), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 34/166 (20%), Positives = 57/166 (34%), Gaps = 14/166 (8%)

Query: 71  QSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYS 130
           +S  + R     +  +   A  W +  + R++A++LL       G+F++RES T  G  +
Sbjct: 547 ESANNDRRGSSDTTELH-YAEKWYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCT 605

Query: 131 LSVRLSRPASWDRIRHYRIQRLDNG---WLYISPRLTFPSLHALVEHYSELAD-----GI 182
           LS          R+ H RI    N    + Y+   L F SL++LV HY            
Sbjct: 606 LSFMY-----HGRVTHCRIHSQQNNGHTYFYLVHALLFDSLYSLVWHYQRYPLRNAKMNF 660

Query: 183 CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEA 228
              L EP                       ++  +        +  
Sbjct: 661 ELLLTEPVPQPNAHANKEWYHDSMTRTDAENVLMRIPRDGAFLVRK 706



 Score = 77.9 bits (190), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 24/119 (20%), Positives = 53/119 (44%), Gaps = 11/119 (9%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQT---RRGCYSLSVRLSRPASWDRI 144
                W ++ ++R  AE +L+      GAFL+R+ ++       +++S R     +  +I
Sbjct: 674 HANKEWYHDSMTRTDAENVLMRIPR-DGAFLVRKCRSDDPSVTSFAISFR-----ADGKI 727

Query: 145 RHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           +H RI++     L++    TF +L  ++  Y +        L+ P   +++  L  +  
Sbjct: 728 KHCRIKQESR--LFVIGNATFETLCDVISFYEKNPLYRKMKLKHPATKEQVQCLLQEPN 784



 Score = 50.9 bits (120), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 4/67 (5%)

Query: 27  MQPERHKVTAVALGSFPAGEQARLSLRLGEPLT-IISEDGDWWTVQSEVSGREY-HMPSV 84
           + P    VT  AL  + A     L+      ++ +I +DG WW  + +  G+     PS 
Sbjct: 800 VPPNFMSVTVKALYDYRAARDDELTFCKHAIISNVIKQDGGWW--RGDYGGKAGMWFPSN 857

Query: 85  YVAKVAH 91
           YV ++  
Sbjct: 858 YVEEMES 864


>UniRef50_UPI00006A0ADF Tensin-1. n=4 Tax=Xenopus (Silurana) tropicalis RepID=UPI00006A0ADF
          Length = 1417

 Score =  100 bits (249), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 35/148 (23%), Positives = 55/148 (37%), Gaps = 17/148 (11%)

Query: 75   SGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVR 134
            S  E      +V   +  W    +SR++A  LL       GAF+IR+S + RG Y L+++
Sbjct: 1128 SSPETRANVKFVQDTSKYWYKPDISRDQAISLL--KDKDPGAFIIRDSHSFRGAYGLAMK 1185

Query: 135  LSRPA-------------SWDRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHYSELA 179
            ++ P              + + +RH+ I+    G           F  L ALV  +S   
Sbjct: 1186 VATPPPNAGQPSKKVGDVTNELVRHFLIETSPRGVKLKGCQNEPYFGCLSALVYQHSITP 1245

Query: 180  DGICCPLREPCVLQKLGPLPGKDTPPPV 207
              + C L  PC             P   
Sbjct: 1246 LALPCKLVIPCRADPSDETKETAVPANS 1273


>UniRef50_Q910A2 Spleen protein tyrosine kinase n=2 Tax=Danio rerio
           RepID=Q910A2_DANRE
          Length = 586

 Score =  100 bits (249), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 40/212 (18%), Positives = 64/212 (30%), Gaps = 47/212 (22%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCY-----SLSVRLSRPASWD 142
                W +  + RE +E  LL      G   I     R+        +L +        +
Sbjct: 158 HEKMPWFHGKIDREDSELRLLNTSRVNGQ--ISNQTKRKQWQKRVPNALCLL-----HNN 210

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLG------ 196
           ++ HYRI +   G L I     F +L  LVEHYS   DG+   L E C            
Sbjct: 211 QVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSEGSAE 270

Query: 197 ------------------------PLPGKDTPPPVTVPTSSLNWKKLDRSLLFLE-APAS 231
                                   P+  +    P   P    + K     L   +    S
Sbjct: 271 NPYKITSNGKDNYSKQGNFLDSAMPMDTQVYESPYADPDELRSTKVNRSDLTLEDGELGS 330

Query: 232 GEASLLSEGLRESLS----SYISLAEDPLDDA 259
           G    +  G+ +         + + ++  D+A
Sbjct: 331 GNFGTVLRGVYQMKKTQKVVAVKILKNDDDNA 362



 Score = 89.0 bits (219), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 28/136 (20%), Positives = 59/136 (43%), Gaps = 8/136 (5%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
               + +  ++RE++E  L   G+  G +L+R+S++  G Y+LS+         +  HY 
Sbjct: 6   HLLPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSY-----GRQFYHYT 60

Query: 149 IQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPL---PGKDTPP 205
           I+R  N    I+   +  +   ++ ++S+ +DG+ C L++P    +       P +D   
Sbjct: 61  IERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHRPRGTEPKVGPFEDLKE 120

Query: 206 PVTVPTSSLNWKKLDR 221
            +        W     
Sbjct: 121 QLIRQYVQQTWNLKGS 136


>UniRef50_A7S295 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7S295_NEMVE
          Length = 642

 Score =  100 bits (249), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 33/193 (17%), Positives = 69/193 (35%), Gaps = 17/193 (8%)

Query: 12  SPSPSSSGPDQEPVSMQPERHKVTA-----VALGSFPAGEQARLSLRLGEPLTIISEDGD 66
            P P        PV  + +     +     VA+  F       ++    E   +      
Sbjct: 450 EPLPPVMDTPPRPVPTESQPVNQDSLPSDRVAM-DFTGTRGKLVTNCK-EIEELTKRQKP 507

Query: 67  WWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 126
             + +   +    +  S         W +  +S ++A  L+   G   G FL+RES +  
Sbjct: 508 QLSRRLSANHFISNSSSTGKELAEEFWFHGRISHDEALVLMKREGFEDGLFLVRESCSVS 567

Query: 127 GCYSLSVRLSRPASWDRIRHYRIQRL----DNGWLYISPRLTFPSLHALVEHYSE-LADG 181
             Y L+  +++     ++ H ++ +        +  +     FPS+  L+ +Y     +G
Sbjct: 568 DVYVLTFCMNK-----KVFHCQLVQDIGPGSKMYYRLDKGPAFPSILELIRYYQRKTVNG 622

Query: 182 ICCPLREPCVLQK 194
           I   L  PC +++
Sbjct: 623 ISVALGRPCTVKR 635


>UniRef50_Q95ZL4 Temporarily assigned gene name protein 163, isoform a n=5
           Tax=Caenorhabditis RepID=Q95ZL4_CAEEL
          Length = 1112

 Score =  100 bits (248), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 11/126 (8%)

Query: 73  EVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLS 132
           + +    H   ++V   +  W    +SRE+A  +L     P G F++R+S +  G + L+
Sbjct: 821 KDTSEIIHHHPLFVKDTSKYWYKPTISREQAINMLR--DKPPGTFVVRDSNSFPGAFGLA 878

Query: 133 VRLSRPASW-------DRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEHYSELADGIC 183
           +++S P          + +RH+ I+    G      +    F SL ALV  +S  A  + 
Sbjct: 879 LKVSTPPPGVNPGDGSELVRHFLIEPSPKGVKLKGCNNEPVFGSLSALVYQHSITALALP 938

Query: 184 CPLREP 189
             L  P
Sbjct: 939 TKLVLP 944


>UniRef50_Q6NR09 CG33993 n=13 Tax=Diptera RepID=Q6NR09_DROME
          Length = 421

 Score =  100 bits (248), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 35/105 (33%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W   G+ RE + E L       GAFL+R+S T+ GC++LS+R+  P+   R+ HY I R 
Sbjct: 286 WFQAGIPREISLEALSRQS--PGAFLVRQSSTKPGCFALSLRVPPPS--PRVAHYLILRT 341

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGP 197
             G+        F SL AL+ H+S + + +  PL  P        
Sbjct: 342 QRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLPRPPSTRSQ 386


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score = 99.4 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 36/204 (17%), Positives = 62/204 (30%), Gaps = 21/204 (10%)

Query: 2   GSLSSRGKTSSPSPSSSGPDQEP----VSMQPERHKVTAVALGSFPAGEQARLSLRLGEP 57
           G   + GK   P       D+ P          + +    AL S       R S R  E 
Sbjct: 299 GGPRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRAL-SVQFEGAERPSFRE-ET 356

Query: 58  LTIISEDGDWW---TVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPG 114
           +        W       +     E       +      W +  +SR +AE  L      G
Sbjct: 357 VRQHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAG 416

Query: 115 GAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYI-SPRLTFPSLHALVE 173
             +L+R S++    YS++++ S         H  + +  +    +      F S+  +V 
Sbjct: 417 --YLVRNSESGNSRYSIALKTS-----QGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVH 469

Query: 174 HYSELADGIC----CPLREPCVLQ 193
           +YS             L  P   +
Sbjct: 470 YYSNEKLPFKGAEHMTLLYPVHSK 493


>UniRef50_Q18684 Protein T13H10.1, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q18684_CAEEL
          Length = 533

 Score = 99.4 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 32/167 (19%), Positives = 55/167 (32%), Gaps = 27/167 (16%)

Query: 91  HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQ 150
             W +  L RE  ++LL       G FL+R +  + G     V        + IRHY I+
Sbjct: 14  EPWYHGLLPREDMKQLLTQR----GDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYVIR 69

Query: 151 RLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVP 210
             +N   +   +  F S+  L+ +Y           +EP                 +  P
Sbjct: 70  EHNN--KFAVDKKWFSSIADLLNYYHRS--------KEPV---------AGGPETVIIRP 110

Query: 211 TSSLNWKKLDRSLLFLEAPASGEASLLSEGLRE----SLSSYISLAE 253
                W+K    +  ++    G    +  G          + I LA+
Sbjct: 111 IGREPWEKQHSDVTLIKKLGEGAFGEVQLGEIRIGNTVKKAAIKLAK 157


>UniRef50_UPI0000ECCD76 tensin 3 n=1 Tax=Gallus gallus RepID=UPI0000ECCD76
          Length = 1314

 Score = 99.0 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 39/177 (22%), Positives = 63/177 (35%), Gaps = 33/177 (18%)

Query: 78   EYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSR 137
            E  +   +V   +  W    +SRE+A  +L       G+F++R+S + RG Y L+++++ 
Sbjct: 1022 EKQVTVKFVQDTSKFWYKPDISREQAIAVL--KDKEPGSFVVRDSHSFRGAYGLAIKVAV 1079

Query: 138  PA-------------SWDRIRHYRIQRLDNGWLYIS--PRLTFPSLHALVEHYSELADGI 182
            P              S + +RH+ I+    G           F SL ALV  +S     +
Sbjct: 1080 PPPSVLQMNNTVGDLSNELVRHFLIECSQKGVHLKGCPNEPCFGSLTALVYQHSITPLAL 1139

Query: 183  CCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGEASLLSE 239
             C L  P       PL       P T   S+                  G A  +  
Sbjct: 1140 PCKLLIP----NRDPLEEMAETSPQTAANSATEL------------LKQGAACNVWY 1180


>UniRef50_UPI0001760C6E PREDICTED: similar to Tensin-like C1 domain-containing phosphatase
            (C1 domain-containing phosphatase and tensin homolog)
            (C1-TEN) (Tensin-2) n=1 Tax=Danio rerio
            RepID=UPI0001760C6E
          Length = 1522

 Score = 99.0 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 49/202 (24%), Positives = 72/202 (35%), Gaps = 27/202 (13%)

Query: 5    SSRGKTSSPSPSSSGPDQEPVSMQPERHKVTAVALGSFPAGEQARLSLRL--GEPLTIIS 62
             S      P P    P    +   P     T  A  S     Q  ++     GE    I 
Sbjct: 1167 PSSSVPQPPLPEKRRPSG--LPGSPNGRSGTLRASMSHQPSGQHHVTFSPSVGELAVPIG 1224

Query: 63   EDGDWWTVQSEVSGREY-HMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRE 121
            +      V+  V G     +   +V   +  W   G+SRE+A   L       GAFLIR+
Sbjct: 1225 Q------VEVGVEGEIGNRVSVKFVQDSSRFWYKPGISREQAIAALKE--REPGAFLIRD 1276

Query: 122  SQTRRGCYSLSVRLSRPASW------------DRIRHYRIQRLDNGWLY--ISPRLTFPS 167
            S + +G Y L+++++ P                 +RH+ I+    G           F S
Sbjct: 1277 SNSFQGAYGLALKVASPPPNVNNHSSKGDPLEQLVRHFLIETGPRGVKIKGCQNEPYFGS 1336

Query: 168  LHALVEHYSELADGICCPLREP 189
            L ALV  +S     + C LR P
Sbjct: 1337 LSALVYQHSITPISLPCALRIP 1358


>UniRef50_C4Q0E9 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4Q0E9_SCHMA
          Length = 1057

 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 17/102 (16%), Positives = 37/102 (36%), Gaps = 11/102 (10%)

Query: 156 WLYISPRLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDTPPPVTVPTSSLN 215
             Y+     F S+  LV H+ + +DG+ C L  P         P +D          S +
Sbjct: 1   MYYVIESNKFTSVSDLVHHHEKHSDGLACTLLYP--------APKRDRTSSELRMDPSFD 52

Query: 216 W-KKLDRSLLFLEAPASGEASLLSEGLRESLS--SYISLAED 254
             +     ++      SG+  ++ E + +  +    +   ++
Sbjct: 53  IREIDRTEIVMKHKLGSGQYGVVYEAVWKPYNVLVAVKTLKE 94


>UniRef50_Q92835 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 n=40
           Tax=Euteleostomi RepID=SHIP1_HUMAN
          Length = 1189

 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 34/142 (23%), Positives = 58/142 (40%), Gaps = 14/142 (9%)

Query: 89  VAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYR 148
           +   W +  ++R KAEELL   G   G+FL+R S++    Y+L V        + +  YR
Sbjct: 1   MVPCWNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYR-----NCVYTYR 54

Query: 149 IQRLDNGWLYISPR-----LTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKDT 203
           I   ++    +          F  L  L+E Y +   G+   L+ P  L++       D 
Sbjct: 55  ILPNEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEED---TGDD 111

Query: 204 PPPVTVPTSSLNWKKLDRSLLF 225
           P   TV +     +   R++  
Sbjct: 112 PEEDTVESVVSPPELPPRNIPL 133


>UniRef50_Q4RVK7 Chromosome 15 SCAF14992, whole genome shotgun sequence. (Fragment)
            n=1 Tax=Tetraodon nigroviridis RepID=Q4RVK7_TETNG
          Length = 1400

 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 32/133 (24%), Positives = 56/133 (42%), Gaps = 16/133 (12%)

Query: 80   HMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPA 139
             + + +V   +  W    +SR++A  +L       G F+IR+S + RG Y L+++++ P 
Sbjct: 1075 QVTAKFVQDTSKFWYKPDISRDQAISVL--KDKEPGCFIIRDSHSFRGAYGLAMKVATPP 1132

Query: 140  ------------SWDRIRHYRIQRLDNGWLYIS--PRLTFPSLHALVEHYSELADGICCP 185
                        S + +RH+ I+    G           F SL ALV  +S     + C 
Sbjct: 1133 PSVLQQSKKADLSNELVRHFLIECTQKGVRLKGCPNEPYFGSLTALVCQHSITPLALPCK 1192

Query: 186  LREPCVLQKLGPL 198
            L  P   ++  P 
Sbjct: 1193 LILPDRGKQPTPS 1205


>UniRef50_B4JFU1 GH19392 (Fragment) n=6 Tax=cellular organisms RepID=B4JFU1_DROGR
          Length = 1708

 Score = 98.7 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 39/135 (28%), Positives = 59/135 (43%), Gaps = 14/135 (10%)

Query: 67   WWTVQSEVSGREYHMPS--------VYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFL 118
            + T+ S       H P+         +    A  W    LSRE A  LLL    P G F+
Sbjct: 1410 YQTIASRQQLNSGHSPTFEVAPDLVKFARNSAKFWYKSLLSREDAIALLLNA--PPGTFV 1467

Query: 119  IRESQTRRGCYSLSVRLSRPASW--DRIRHYRIQRLDNGWLY--ISPRLTFPSLHALVEH 174
            +R+S T +  Y L +R+++P +   + +RH+ I+    G          TF SL AL+  
Sbjct: 1468 VRDSTTYKNAYGLVLRVAQPPAGSQELVRHFLIEPTQRGVRLKGCENEPTFTSLSALIYE 1527

Query: 175  YSELADGICCPLREP 189
            +S     + C LR P
Sbjct: 1528 HSINKLALPCLLRIP 1542


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score = 98.3 bits (243), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 21/144 (14%)

Query: 53  RLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGN 112
           ++ E L I +E  D + +  +                   W    ++R +AEE+L   G 
Sbjct: 590 KINEWLGIKNETEDQYALMEDEDD--------LPHHEERTWYVGKINRTQAEEML--SGK 639

Query: 113 PGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALV 172
             G FLIRES ++RGCY+ SV +          H  I R   G+ +  P   + SL  LV
Sbjct: 640 RDGTFLIRES-SQRGCYACSVVVDGDTK-----HCVIYRTATGFGFAEPYNLYGSLKELV 693

Query: 173 EHYS-----ELADGICCPLREPCV 191
            HY      +  D +   L  P  
Sbjct: 694 LHYQHASLVQHNDALTVTLAHPVR 717



 Score = 94.8 bits (234), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 32/136 (23%), Positives = 55/136 (40%), Gaps = 14/136 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRE-SQTRRGCYSLSVRLSRPASWDRIRHYRIQR 151
           W +  +SRE+  E L     P G FL+R+ S   +G Y+L++R        ++ H     
Sbjct: 330 WYWGDISREEVNEKLR--DTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH----- 382

Query: 152 LDNGWLYISPRLTFPSLHALVEHYSELADG-----ICCPLREPCVLQKLGPLPGKDTPPP 206
             +G    S  LTF S+  L+ HY   +       +   L  P    +   +  +D+   
Sbjct: 383 -RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEA 441

Query: 207 VTVPTSSLNWKKLDRS 222
           V       + +  D+S
Sbjct: 442 VGAQLKVYHQQYQDKS 457


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 98.3 bits (243), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 34/175 (19%), Positives = 64/175 (36%), Gaps = 18/175 (10%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  L+R  AE LLL  G   G++L+R+S    G YSLSVR         ++H+ ++  
Sbjct: 35  WYHGNLTRHAAEALLLSNG-CDGSYLLRDSNETTGLYSLSVRAKDS-----VKHFHVEYT 88

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELAD-----GICCPLREPCVLQKLGPLPGKDTPPPV 207
             G+ +      F SL   V+H++         G    L+ P   +   P   +      
Sbjct: 89  --GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHT 146

Query: 208 TVPTSSLNWKKLDRSLLFLEAPA--SGEASLL--SEGLR-ESLSSYISLAEDPLD 257
            + T       +  +          + +  L+   +        + +   +D + 
Sbjct: 147 AMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMS 201


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score = 98.3 bits (243), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 36/203 (17%), Positives = 65/203 (32%), Gaps = 49/203 (24%)

Query: 64  DGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 123
           +      +   +  E   P       +  W +  L+ ++AE+LL   G P G+FL+RESQ
Sbjct: 81  EQQGLLREKNSNVIELKYPLNCQDPTSERWYHGHLTGKEAEKLLTEKGKP-GSFLVRESQ 139

Query: 124 TRRGCYSLSVRLS-RPASWDRIRHYRIQRLD----------------------------- 153
           ++ G + LSV  +         +  R  R D                             
Sbjct: 140 SKPGDFVLSVLTNEDKMETGDPQTSRDPRDDPLPGGQPACPRFACRAGPSWEPCALEPHR 199

Query: 154 --------NGWLYISPRLTFPSLHALVEHYSELA----DGICCPLREPCVLQKLGPLPGK 201
                   +G   +     F +L  LVEHY +       G    L++P    ++     +
Sbjct: 200 ASVALLQPDGKYDVGGGERFDTLTDLVEHYKKNPMVEKSGAVVHLKQPFNATRINAANIE 259

Query: 202 DTPPPVTVPTSSLN------WKK 218
           +    +              W++
Sbjct: 260 NRVRELNKMADHSEKAKQGFWEE 282



 Score = 86.3 bits (212), Expect = 9e-16,   Method: Composition-based stats.
 Identities = 36/166 (21%), Positives = 63/166 (37%), Gaps = 25/166 (15%)

Query: 93  WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQRL 152
           W +  +S  +AE+LLL  G   G+FL R S++  G ++LSVR       D + H +IQ  
Sbjct: 4   WFHPNISGIEAEKLLLTRG-VHGSFLARPSKSNPGDFTLSVR-----RNDEVTHIKIQNT 57

Query: 153 DNGWLYISPRLTFPSLHALVEHYSELADGI------CCPLREPCVLQKLGPLPGKDTPPP 206
            + +  +     F     LV++Y+E    +         L+ P            +   P
Sbjct: 58  GD-YYDLYGGEKFARKPELVQYYTEQQGLLREKNSNVIELKYPL-----------NCQDP 105

Query: 207 VTVPTSSLNWKKLDRSLLFLEAPASGEASLLSEGLRESLSSYISLA 252
            +      +    +   L  E    G   L+ E   +     +S+ 
Sbjct: 106 TSERWYHGHLTGKEAEKLLTEKGKPGSF-LVRESQSKPGDFVLSVL 150


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score = 98.3 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 11/121 (9%)

Query: 88  KVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHY 147
                W +  ++R+++EELLL      G+F++R S++R G Y+LSV        + +  Y
Sbjct: 1   MSDEIWYHGRVNRQQSEELLLSAA-VDGSFVVRASESRAGAYALSVLF-----NNSVHTY 54

Query: 148 RIQRLDNGWLYISP-----RLTFPSLHALVEHYSELADGICCPLREPCVLQKLGPLPGKD 202
           RI   +N  L +       +  F SL  LV  Y    +G+ C L  P  L          
Sbjct: 55  RILPTENNTLAVQTVNGVQQRKFKSLTELVHEYRNSQNGLVCGLSNPVGLDSKTRPSTSS 114

Query: 203 T 203
            
Sbjct: 115 A 115


>UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3XYL7_BRAFL
          Length = 296

 Score = 98.3 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 34/105 (32%), Positives = 49/105 (46%), Gaps = 7/105 (6%)

Query: 83  SVYVAKVAHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWD 142
                     W    + RE A   L       GAF++RES +  GCY+LS+R     +  
Sbjct: 188 MNNQDYRGAAWYKGNVPREMAMAELERQ--CAGAFMVRESGSNPGCYALSLR-----TMA 240

Query: 143 RIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            I +Y I + D G+  +    +FP LH L+ HYS  A+ + C LR
Sbjct: 241 GISNYLIGKTDKGYTIMGFGKSFPDLHTLIIHYSVYAEMLPCRLR 285


>UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q3U8_BRUMA
          Length = 1284

 Score = 97.9 bits (242), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 31/154 (20%), Positives = 51/154 (33%), Gaps = 16/154 (10%)

Query: 47  QARLSLRLGEPLTIISEDGDWWTVQSEVSGREYHMPSVYVAKVAHGWLYEGLSREKAE-E 105
             +  LR  + L    +D +    Q  ++             +   W +    R+ A   
Sbjct: 525 DNQGILRRQDSLGNAHDDEN----QDVLTNLTGFGVPPEEMHITEEWFHGKTDRDTARIR 580

Query: 106 LLLLPGNPGGAFLIRESQTRRGCYSLSVRLSRPASWDRIRHYRIQR---LDNGWLYISPR 162
           LL       G FL+R+S    G YSLS         +++ H RI+          Y    
Sbjct: 581 LLEHKDKGNGLFLVRDSTIFIGDYSLSFL-----HNEKVHHCRIRTRMVNGEKKYYFLEN 635

Query: 163 LTFPSLHALVEHYSELADGIC---CPLREPCVLQ 193
               +L+ L+ HY++           L  PC   
Sbjct: 636 KQMDTLYELISHYTKERLRTPNFSTTLITPCPQP 669



 Score = 85.2 bits (209), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 38/199 (19%), Positives = 65/199 (32%), Gaps = 31/199 (15%)

Query: 69  TVQSEVSGREYHMPSVYVAKVAHG-WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRG 127
            +++         P           W  E   R +AEELL       GAFL+R S T + 
Sbjct: 652 RLRTPNFSTTLITPCPQPCPHLGMIWFCEKTDRNRAEELLNTV-QQDGAFLLRFSSTDKN 710

Query: 128 CYSLSVRLSRPASWDRIRHYRIQRLDNGWLYISPRLTFPSLHALVEHYSELADGICCPLR 187
            + LS+R+        I HY ++R  +G +++  +  F +L+ +VE+YS         L+
Sbjct: 711 VFVLSLRVD-----GEIWHYHLKR--DGRIFVVNQTIFENLNQIVEYYSTREFVRGICLK 763

Query: 188 EPCVLQKLGPLPGKDTPPPVTVPTSSLNWKKLDRSLLFLEAPASGE-------------- 233
            P   +                    +  K +D+ +  + A  S                
Sbjct: 764 YPVG-EDTIIGSAGICCSTDRALGCYMELKDIDKEV-LVRAIESYNGSLPCELSFPVNAV 821

Query: 234 ------ASLLSEGLRESLS 246
                       G     S
Sbjct: 822 INVFRKDGDRWRGKYRGRS 840


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.306    0.129    0.356 

Lambda     K      H
   0.267   0.0395    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,436,684,697
Number of Sequences: 3077464
Number of extensions: 55537104
Number of successful extensions: 297830
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 2429
Number of HSP's successfully gapped in prelim test: 3024
Number of HSP's that attempted gapping in prelim test: 287311
Number of HSP's gapped (non-prelim): 8806
length of query: 259
length of database: 1,040,396,356
effective HSP length: 126
effective length of query: 133
effective length of database: 652,635,892
effective search space: 86800573636
effective search space used: 86800573636
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.5 bits)
S2: 91 (39.7 bits)
