|   |   |
185 | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | |
. | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
. | 230 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  | . |
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|  |  |  | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | R | P | R | E | E | F | T | L | C | K | K | L | G | A | G | Y | F | G | E | V | F | E | A | L | W | . |
K | G | Q | V | H | V | A | V | K | V | I | S | R | D | N | L | L | H | . |
. |
. |
. |
. |
. |
. |
Q | H | T | F | Q | A | E | I |
| Query Conservation |   |
|
|   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |
|
|   |
|   |   |   |   |   | . |   |   |   |   |   |
|
|
|
|   |
|   |   |   |   |   |   |   | . | . | . | . | . | . | . |   |   |   |
|   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|   |   |   |   |
|   |
|   |   |   |
|
|   |
|   |
|
|   |
|
|   |
|   |   |   |   |   |   |   |   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
| Template Sequence |   |
T | L | A | D | N | E | I | E | Y | E | K | Q | I | G | K | G | G | F | G | L | V | H | K | G | R | L | V | K | D | K | S | V | V | A | I | K | S | L | I | L | G | D | S | E | G | E | T | E | M | I | E | K | F | Q | E | F | Q | R | E | V |
| Template Known Secondary structure |   |
B |
|
| T | T | T |  |  |  |  |  |  |
|
|
|
| S | S | S |
|  |  |  |  |  |  | T | T | T |
|
|  |  |  |  |  |  |
|
|
|
| T | T | T |
|
| T | T | G | G | G | G |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1020 | . | . | . | . | . | . | . | . | . | 1030 | . | . | . | . | . | . | . | . | . | 1040 | . | . | . | . | . | . | . | . | . | 1050 | . | . | . | . | . | . | . | . | . | 1060 | . | . | . | . | . | . | . | . | . | 1070 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
237 | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Q | A | M | K | K | L | R | H | K | H | I | L | S | L | Y | A | V | A | T | A | G | D | P | V | Y | I | I | T | E | L | M | P | K | G | N | L | L | Q | L | L | R | D | S | D | E | K | A | L | P | I | L | E | L | V | D | F | A | S | Q | V |
| Query Conservation |   |
  |
|
|   |   |
|   |
|   |
|
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |
|
|   |
|   |   |   |   |
|   |
|   |   |   |
|   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|   |   |
|   |
|   |
|
|
|   |   |   |   |   |   |   | . | . |   |   |   |   |   |
|   |   |
|   |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
F | I | M | S | N | L | N | H | P | N | I | V | K | L | Y | G | L | M | H | . |
. |
N | P | P | R | M | V | M | E | F | V | P | C | G | D | L | Y | H | R | L | L | D | K | A | H | P | . |
I | K | W | S | V | K | L | R | L | M | L | D | I |
| Template Known Secondary structure |   |
 |  |  | T | T |
|
|
| T | T | B |
|
|  |  |  |  |  | T | . | . | T | T | T |  |  |  |  |  |
|
| T | T |
| B |  |  |  |  |  | T |
| T | T | S |
| . |
|
|  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1080 | . | . | . | . | . | . | . | . | . | 1090 | . | . | . | . | . | . | . | . | |
|
. | 1100 | . | . | . | . | . | . | . | . | . | 1110 | . | . | . | . | . | . | . | . | . | 1120 | . | . | . | |
. | . | . | . | . | . | 1130 | . | . | . | . | . | . |
|   |
|   |   |
297 | . | . | 300 | . | . | . | . | . | . | . | |
|
. | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | |
|
|
|
|
. | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
| . | . |
|  |  |
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|  |  |  |
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
A | E | G | M | C | Y | L | E | S | Q | N | . |
. |
Y | I | H | R | D | L | A | A | R | N | V | L | V | T | E | . |
. |
. |
. |
. |
N | N | L | C | K | V | G | D | F | G | L | A | R | L | V | K | E | D | I | Y | L | S | H | E | H | N | V |
| Query Conservation |   |
|   |
|
|   |
|
|
|   |   |   | . | . |   |
|
|
|
|
|
|   |   |
|
|
|   |   |   | . | . | . | . | . |   |   |   |   |
|
|   |
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . |
| Template Sequence |   |
A | L | G | I | E | Y | M | Q | N | Q | N | P | P | I | V | H | R | D | L | R | S | P | N | I | F | L | Q | S | L | D | E | N | A | P | V | C | A | K | V | A | D | F | G | T | S | Q | Q | S | V | H | S | V | S | G | L | L | G | N | . |
. |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  | T | S | S | S |
|
| B |
| S |
|
| S | G | G | G |  |  |  | S |
|
|
| T | T | S | S |
| S |  |  |  |
|
|
| T | T |
| B |
|
| S | S |
|  |  |
|
|
| S |
| . | . |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|
|  |  |
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
| . | . |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1137 | . | . | 1140 | . | . | . | . | . | . | . | . | . | 1150 | . | . | . | . | . | . | . | . | . | 1160 | . | . | . | . | . | . | . | . | . | 1170 | . | . | . | . | . | . | . | . | . | 1180 | . | . | . | . | . | . | . | . | . | 1190 | . | . | . | . | |
|
|   |
|   |   |
350 | . | . | . | . | . | . | . | . | . | 360 | |
|
. | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | |
|
|
. | . | . | 400 | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  | . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  | . | . | . |  |  |  |  |  |
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
| Query Sequence |   |
P | Y | K | W | T | A | P | E | A | L | S | . |
. |
R | G | H | Y | S | I | K | S | D | V | W | S | F | G | V | L | L | H | E | I | F | S | R | G | Q | M | P | Y | P | G | M | S | N | H | E | T | . |
. |
. |
F | L | R | V | D | A | G | Y |
| Query Conservation |   |
  |   |   |   |   |
|
|
|   |   |   | . | . |   |   |   |   |
|   |
|
|
|
|
|
|
|
|
|   |
|   |
|
|   |
|   |
|   |   |
|   |   |   |   |   |   |   |   |   | . | . | . |   |   |   |
|   |   |
|   |
| Alig confidence |   |
. |
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
| Template Conservation |   |
. |   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|   |
|
|
|
|
|   | . |
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
. |
F | Q | W | M | A | P | E | T | I | G | A | E | E | E | S | Y | T | E | K | A | D | T | Y | S | F | A | M | I | L | Y | T | I | L | T | . |
G | E | G | P | F | D | E | Y | S | Y | G | K | I | K | F | I | N | M | I | R | E | E | G | L |
| Template Known Secondary structure |   |
. | T | T | T | S |
|  |  |  |  | S |
| T | T | S |  |  |
| T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | S | S |
| T | T | T | T |
|
|
|
|  |  |  |  |  |  |  |  |  |  | S |
|
|
| Template Predicted Secondary structure |   |
. |
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  | . |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
|
1195 | . | . | . | . | 1200 | . | . | . | . | . | . | . | . | . | 1210 | . | . | . | . | . | . | . | . | . | 1220 | . | . | . | . | . | . | . | . | |
. | 1230 | . | . | . | . | . | . | . | . | . | 1240 | . | . | . | . | . | . | . | . | . | 1250 | . | . |
|   |
|   |   |
405 | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
R | M | P | C | P | L | E | C | P | P | N | I | H | K | L | M | L | S | C | W | S | R | D | P | K | Q | R | P | C | F | K | D | L | C | E | K | L | T | G | I |
| Query Conservation |   |
|   |   |   |
|   |   |   |
|   |   |
|   |   |
|
|   |   |
|   |   |   |
|
|   |   |
|
|
|   |   |   |
|   |   |   |
|   |   |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |
|   |   |
|   |   |
|
|   |   |   |
|   |   |
|
|   |   |
|
|
|   |   |
|
|
|   |   |
|   |   |
|
| Template Sequence |   |
R | P | T | I | P | E | D | C | P | P | R | L | R | N | V | I | E | L | C | W | S | G | D | P | K | K | R | P | H | F | S | Y | I | V | K | E | L | S | E | L |
| Template Known Secondary structure |   |
|
|
|
|
| T | T | S |
|  |  |  |  |  |  |  |  |  |  | T |
| S | S | G | G | G | S |
|
|  |  |  |  |  |  |  |  |  | T |
|
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1253 | . | . | . | . | . | . | 1260 | . | . | . | . | . | . | . | . | . | 1270 | . | . | . | . | . | . | . | . | . | 1280 | . | . | . | . | . | . | . | . | . | 1290 | . | . |
|   |