|   |   |
399 | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
P | K | D | L | T | F | L | K | E | L | G | T | G | Q | F | G | V | V | K | Y | G | K | W | R | G | Q | Y | D | V | A | I | K | M | I | R | E | G | S | M | S | E | D | E | F | I | E | E | A | K | V | M | M | N | L | S | H | E | K | L | V |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |
|
|   |
|   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |
|   |
|   |
|
|
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |
|   |
|   |   |   |
|
|   |
|   |
|
|   |
|
|   |   |   |   | . |   |   |   |   |
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|   |   |
|   |
|   |
|
|
|
| Template Sequence |   |
A | R | D | I | T | L | L | E | C | V | G | K | G | R | Y | G | E | V | W | R | G | S | W | . |
Q | G | E | N | V | A | V | K | I | F | S | S | R | D | E | K | S | W | F | R | E | T | E | L | Y | N | T | V | M | L | R | H | E | N | I | L |
| Template Known Secondary structure |   |
T | T | T |  |  |  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  | . | T | T |  |  |  |  |  |  |  |  |
| G | G | G |  |  |  |  |  |  |  |  |  |  |  |  |  | S |
|
|
|
| T | T | B |
|
| Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  | . |
|
|  |  |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
205 | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | |
. | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . |
|   |
|   |   |
459 | 460 | . | . | . | |
|
|
|
. | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  | . | . | . | . |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Q | L | Y | G | V | . |
. |
. |
. |
C | T | K | Q | R | P | I | F | I | I | T | E | Y | M | A | N | G | C | L | L | N | Y | L | R | E | M | R | H | R | F | Q | T | Q | Q | L | L | E | M | C | K | D | V | C | E | A | M | E | Y | L | E | S |
| Query Conservation |   |
  |
|   |
|   | . | . | . | . |   |   |   |   |   |   |   |   |
|
|   |
|   |   |   |   |
|
|
|   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |
|
|
|   |
|
|   |
|
|
|   |
| Alig confidence |   |
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
G | F | I | A | S | D | M | T | S | R | H | S | S | T | Q | L | W | L | I | T | H | Y | H | E | M | G | S | L | Y | D | Y | L | Q | L | T | T | . |
. |
L | D | T | V | S | C | L | R | I | V | L | S | I | A | S | G | L | A | H | L | H | I |
| Template Known Secondary structure |   |
|  |  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |
|
| T | T |
| B |  |  |  |  |  |  |  |
|
| . | . | B |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S |
| Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |
|
|
|
|
| . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
264 | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | |
|
300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . |
|   |
|   |   |
515 | . | . | |
|
|
|
|
|
|
|
. | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | . | . | |
|
|
. | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . |
| Predicted Secondary structure |   |
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|  |  |  |
|
| . | . | . |
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |
| Query SS confidence |   |
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
K | Q | F | . |
. |
. |
. |
. |
. |
. |
. |
L | H | R | D | L | A | A | R | N | C | L | V | N | D | Q | G | V | V | K | V | S | D | F | G | L | S | R | Y | V | L | . |
. |
. |
D | D | E | Y | T | S | S | V | G | S | K | F | P | V | R | W |
| Query Conservation |   |
  |   |
| . | . | . | . | . | . | . | . |
|
|
|
|
|   |   |   |
|
|
|
|   |   |   |   |   |
|
|
|   |
|
|
|
|
|   |   |   |   | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
| Alig confidence |   |
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
E | I | F | G | T | Q | G | K | P | A | I | A | H | R | D | L | K | S | K | N | I | L | V | K | K | N | G | Q | C | C | I | A | D | L | G | L | A | V | M | H | S | Q | S | T | N | Q | L | D | V | G | N | N | P | R | V | G | T | K | R | Y |
| Template Known Secondary structure |   |
| B |
| S | T | T |
| B |
|  |  |  |
| S |
|
| S | G | G | G |  |  |  |
| T | T | S |
|  |  |  |
|
|
| T | T |
|  |  |  |  | T | T | T | T |  |  |  |
|
|
|
|
|
|
|
|
| G | G | G |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
322 | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . |
|   |
|   |   |
564 | . | . | . | . | . | 570 | . | . | . | |
|
|
|
|
|
. | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600 | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Predicted Secondary structure |   |
|
|  |  |  |  |  |
|
|
| . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
| Query Sequence |   |
S | P | P | E | V | L | M | Y | S | K | . |
. |
. |
. |
. |
. |
F | S | S | K | S | D | I | W | A | F | G | V | L | M | W | E | I | Y | S | L | G | K | M | P | Y | E | R | F | T | N | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
| Query Conservation |   |
  |
|
|
|   |   |   |   |   |   | . | . | . | . | . | . |   |
|   |
|
|
|
|
|
|   |
|
|   |
|   |
|
|   |
|   |
|   |   |
|   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Template Conservation |   |
  |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |
|   |
|
|   |
|
|
|   | . |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
M | A | P | E | V | L | D | E | T | I | Q | V | D | C | F | D | S | Y | K | R | V | D | I | W | A | F | G | L | V | L | W | E | V | A | R | . |
R | M | V | S | N | G | I | V | E | D | Y | K | P | P | F | Y | D | V | V | P | N | D | P | S |
| Template Known Secondary structure |   |
|
|  |  |  |  | T | T |
|
|
| T | T |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | . | T | B |
| B | T | T | B |
|
|
|
|
|
| T | T | T | T | T | S |
| S | S |
|
|
| Template Predicted Secondary structure |   |
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
382 | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | |
. | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 |
|   |
|   |   |
|
604 | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | |
|
|
|
|
|
. | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . |
| Predicted Secondary structure |   |
. |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
. |
S | E | T | A | E | H | I | A | Q | G | L | R | L | Y | R | P | H | L | . |
. |
. |
. |
. |
. |
A | S | E | R | V | Y | T | I | M | Y | S | C | W | H | E | K | A | D | E | R | P | S | F | K | I | L | L | S | N | I | L | D | V |
| Query Conservation |   |
. |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |
|   |   | . | . | . | . | . | . |   |
|   |   |
|   |   |
|
|   |   |
|
|   |   |
|
|   |   |
|
|
|   |   |   |
|   |   |   |
|   |   |   |
| Alig confidence |   |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|
|   |   |
|
|   |   |
|
|
|
|   |
|
|
|   |   |
|   |   |
|
| Template Sequence |   |
F | E | D | M | R | K | V | V | C | V | D | Q | Q | R | P | N | I | P | N | R | W | F | S | D | P | T | L | T | S | L | A | K | L | M | K | E | C | W | Y | Q | N | P | S | A | R | L | T | A | L | R | I | K | K | T | L | T | K | I |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  | T | T | S |
|
|
|
|
|
|
| G | G | G | G | G | S |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| S | S | G | G | G | S |
|
|  |  |  |  |  |  |  |  |  |  |
|
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
441 | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . |
|   |