Job Description P06239 Confidence 100.00% Date Wed May 9 17:41:23 BST 2012 Rank 60 Aligned Residues 257 % Identity 36% Template c3v5qB_ PDB info PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:nt-3 growth factor receptor; PDBTitle: discovery of a selective trk inhibitor with efficacy in rodent cancer2 tumor models Resolution 2.20 Å

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

		238	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.		.	.	.	260	.	.	.	.	.		.	.	.	.	270	.	.	.	.	.		.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.
Predicted Secondary structure																					.										.											.
Query SS confidence																					.										.											.
Query Sequence		W	E	V	P	R	E	T	L	K	L	V	E	R	L	G	A	G	Q	F	.	G	E	V	W	M	G	Y	Y	N	.	G	H	T	K	V	A	V	K	S	L	.	K	Q	G	S	M	S	P	D	A	F	L	A	E	A	N	L	M	K	Q	L	Q	H	Q	R	L	V	R	L	Y	A	V	V	T	Q	E	P	I	Y	I
Query Conservation																					.										.											.
Alig confidence																					.										.											.																																.
Template Conservation																																																																										.
Template Sequence		Q	H	I	K	R	R	D	I	V	L	K	R	E	L	G	F	K	V	F	L	A	E	C	Y	N	L	S	P	T	K	D	K	M	L	V	A	V	K	A	L	K	D	P	T	L	A	A	R	K	D	F	Q	R	E	A	E	L	L	T	N	L	Q	H	E	H	I	V	K	F	Y	G	V	.	C	G	D	P	L	I	M
Template Known Secondary structure						G	G	G																		S			S	S	S	S											S																						T	T	B							.
Template Predicted Secondary structure																																																																										.
Template SS confidence
		531	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.		.	.	.	.	.	.	.
		315	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	T	E	Y	M	E	N	G	S	L	V	D	F	L	K	T	P	S	G	I	K	L	T	I	N	K	L	L	D	M	A	A	Q	I	A	E	G	M	A	F	I	E	E	R	N	Y	I	H	R	D	L	R	A	A	N	I	L	V	S	D	T	L	S	C	K	I	A	D	F	G	L	A	R	L	I	E	D	N	E	Y
Query Conservation
Alig confidence																					.																																																							.	.	.	.	.
Template Conservation																					.																																																							.	.	.	.	.
Template Sequence		V	F	E	Y	M	K	H	G	D	L	N	K	F	L	R	A	H	G	P	.	E	L	G	L	S	Q	M	L	H	I	A	S	Q	I	A	S	G	M	V	Y	L	A	S	Q	H	F	V	H	R	D	L	A	T	R	N	C	L	V	G	A	N	L	L	V	K	I	G	D	F	G	M	D	V	Y	.	.	.	.	.	S
Template Known Secondary structure							T	T									T	T			.																								T	T				S			S	G	G	G					G	G	G												S	.	.	.	.	.	G
Template Predicted Secondary structure																					.																																																							.	.	.	.	.
Template SS confidence
		616	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.		.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.						.
		395	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	A	R	E	G	A	K	F	P	I	K	W	T	A	P	E	A	I	N	Y	G	T	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	I	V	T	H	G	R	I	P	Y	P	G	M	T	N	P	E	V	I	Q	N	L	E	R	G	Y	R	M	V	R	P	D	N	C	P	E	E	L	Y	Q	L	M	R
Query Conservation
Alig confidence
Template Conservation
Template Sequence		T	D	Y	Y	R	T	M	L	P	I	R	W	M	P	P	E	S	I	M	Y	R	K	F	T	T	E	S	D	V	W	S	F	G	V	I	L	W	E	I	F	T	Y	G	K	Q	P	W	F	Q	L	S	N	T	E	V	I	E	C	I	T	Q	G	R	V	L	E	R	P	R	V	C	P	K	E	V	Y	D	V	M	L
Template Known Secondary structure		G	G		B				B		G	G	G																												T	T	T	S			T	T	T	T	S												T							T	T
Template Predicted Secondary structure
Template SS confidence
		707	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.
		475	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	C	W	K	E	R	P	E	D	R	P	T	F	D	Y	L	R	S	V	L	E	D	F	F	T	A	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		G	C	W	Q	R	E	P	Q	Q	R	L	N	I	K	E	I	Y	K	I	L	H	A	L	G	K	A	T
Template Known Secondary structure						S	S	G	G	G	S																T
Template Predicted Secondary structure
Template SS confidence
		805	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.

No model constructed - rank, confidence too low

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions