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Job DescriptionP06239
Confidence100.00%DateWed May 9 17:41:23 BST 2012
Rank97Aligned Residues241
% Identity41%Templatec3k54A_
PDB info PDB header:transferaseChain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: structures of human bruton's tyrosine kinase in active and inactive2 conformations suggests a mechanism of activation for tec family3 kinases.
Resolution1.94 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   236...240.........250.........260.........270.........280.........290.........300......... 310....
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Query Sequence  DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQ. EPIYI
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Template Sequence  GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK. . . . . . . EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFI
Template Known Secondary structure  GGGB

GGGSTTSS
TTT

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TT


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   393......400.........410.........420.........430... ......440.........450.........460.....
 
   315....320.........330.........340.........350.........360.........370.........380.........390....
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Query Sequence  ITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEY
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Template Sequence  ITEYMANGCLLNYLREMR. HRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGFP. . . . . . . .
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GG.G


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SGGG
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   473......480.........490 .........500.........510.........520.........530.........540...
 
   395....400.........410.........420.........430.........440.........450.........460.........470....
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Query Sequence  TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR
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Template Sequence  . . . . . . . . . VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMY
Template Known Secondary structure  .........GGG





TTS

TTTTS
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TTS
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   561........570.........580.........590.........600.........610.........620.........630.
 
   475....480.........490.........500.
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Query Sequence  LCWKERPEDRPTFDYLRSVLEDFFTAT
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Template Sequence  SCWHEKADERPTFKILLSNILDVMDEE
Template Known Secondary structure  TT
SSGGGS


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   632.......640.........650........
 
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No model constructed - rank, confidence too low




Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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