Job Description P51813 Confidence 100.00% Date Fri May 25 10:09:19 BST 2012 Rank 4 Aligned Residues 429 % Identity 38% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å

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		213	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.		240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.
Predicted Secondary structure																													.
Query SS confidence																													.
Query Sequence		L	A	Q	Y	D	S	N	S	K	K	I	Y	G	S	Q	P	N	F	N	M	Q	Y	I	P	R	E	D	.	F	P	D	W	W	Q	V	R	K	L	K	S	S	S	S	S	E	D	V	A	S	S	N	Q	K	E	R	N	V	N	H	T	T	S	K	I	S	W	E	F	P	E	S	S	S	S	E	E	E	E	N	L
Query Conservation																													.
Alig confidence																													.																.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		V	A	L	Y	D	Y	E	S	R	T	E	T	D	L	S	F	K	K	G	E	R	L	Q	I	V	N	N	T	E	G	D	W	W	L	A	H	S	L	S	T	G	Q	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	G	Y	I	P	S	N	Y	V	A	P	S	D	S	I
Template Known Secondary structure				S	S		B				S	S	S	B			B		T	T									S	S	S	S							T	T	T				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.					G	G	G				T	T	S	G
Template Predicted Secondary structure																																													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		87	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.																								130	.	.	.	.	.	.	.	.	.	140	.	.	.
		292	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.		.	.	.	.	.	.	.	320	.	.	.	.		.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																							.													.
Query SS confidence																							.													.
Query Sequence		D	D	Y	D	W	F	A	G	N	I	S	R	S	Q	S	E	Q	L	L	R	Q	.	K	G	K	E	G	A	F	M	V	R	N	S	.	S	Q	V	G	M	Y	T	V	S	L	F	S	K	A	V	N	D	K	K	G	T	V	K	H	Y	H	V	H	T	N	A	E	N	K	L	Y	L	A	E	N	Y	C	F	D	S
Query Conservation																							.													.
Alig confidence																							.													.														.
Template Conservation																																																		.
Template Sequence		Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E	R	L	L	L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	K	G	A	Y	C	L	S	V	S	D	F	.	D	N	A	K	G	L	N	V	K	H	Y	K	I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S
Template Known Secondary structure		G	G	S	T	T	B			S											T		T	T			T	T								S	S	S	T	T										.		T	T	T										B		.			S						T	T				S	S
Template Predicted Secondary structure																																																		.
Template SS confidence
		144	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.		.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.
		370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	P	K	L	I	H	Y	H	Q	H	N	S	A	G	M	I	T	R	L	R	H	P	V	S	T	K	A	N	K	V	P	D	S	V	S	L	G	N	G	I	W	E	L	K	R	E	E	I	T	L	L	K	E	L	G	S	G	Q	F	G	V	V	Q	L	G	K	W	K	G	Q	Y	D	V	A	V	K	M	I	K	E
Query Conservation
Alig confidence																													.	.	.
Template Conservation																													.	.	.
Template Sequence		L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H	R	L	T	T	V	C	P	T	S	K	.	.	.	P	Q	T	Q	G	L	A	K	D	A	W	E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M	G	T	W	N	G	T	T	R	V	A	I	K	T	L	K	P
Template Known Secondary structure														T	T	S	S	S											.	.	.				S	S	S	S	T	T		S	B			G	G	G											S	S									T	T	T										T
Template Predicted Secondary structure																													.	.	.
Template SS confidence
		223	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.				250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.
		450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.		.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																						.
Query SS confidence																																																						.
Query Sequence		G	S	M	S	E	D	E	F	F	Q	E	A	Q	T	M	M	K	L	S	H	P	K	L	V	K	F	Y	G	V	C	S	K	E	Y	P	I	Y	I	V	T	E	Y	I	S	N	G	C	L	L	N	Y	L	.	R	S	H	G	K	G	L	E	P	S	Q	L	L	E	M	C	Y	D	V	C	E	G	M	A	F	L	E
Query Conservation																																																						.
Alig confidence																																	.																					.
Template Conservation																																	.
Template Sequence		G	T	M	S	P	E	A	F	L	Q	E	A	Q	V	M	K	K	L	R	H	E	K	L	V	Q	L	Y	A	V	V	S	.	E	E	P	I	Y	I	V	T	E	Y	M	S	K	G	S	L	L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E
Template Known Secondary structure		T	S	S																		T	T	B									.	S	S	S									T	T								S					T	T
Template Predicted Secondary structure																																	.
Template SS confidence
		300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330		.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.
		529	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	H	Q	F	I	H	R	D	L	A	A	R	N	C	L	V	D	R	D	L	C	V	K	V	S	D	F	G	M	T	R	Y	V	L	D	D	Q	Y	V	S	S	V	G	T	K	F	P	V	K	W	S	A	P	E	V	F	H	Y	F	K	Y	S	S	K	S	D	V	W	A	F	G	I	L	M	W	E	V	F	S	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L	V	G	E	N	L	V	C	K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I	K	W	T	A	P	E	A	A	L	Y	G	R	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K
Template Known Secondary structure			T	T				S			S	G	G	G					G	G	G							T	T	S	T	T	T								T	T		S	T	T	S		G	G	G	S																											T	T	T
Template Predicted Secondary structure
Template SS confidence
		379	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.
		609	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	K	Q	P	Y	D	L	Y	D	N	S	Q	V	V	L	K	V	S	Q	G	H	R	L	Y	R	P	H	L	A	S	D	T	I	Y	Q	I	M	Y	S	C	W	H	E	L	P	E	K	R	P	T	F	Q	Q	L	L	S	S	I	E	P	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		G	R	V	P	Y	P	G	M	V	N	R	E	V	L	D	Q	V	E	R	G	Y	R	M	P	C	P	P	E	C	P	E	S	L	H	D	L	M	C	Q	C	W	R	K	E	P	E	E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y
Template Known Secondary structure		T			S	S	T	T												T	T							T	T													T		S	S	G	G	G	S												T	S
Template Predicted Secondary structure
Template SS confidence
		459	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.