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Job DescriptionP42685
Confidence100.00%DateTue Apr 3 14:35:51 BST 2012
Rank87Aligned Residues242
% Identity45%Templatec3k54A_
PDB info PDB header:transferaseChain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: structures of human bruton's tyrosine kinase in active and inactive2 conformations suggests a mechanism of activation for tec family3 kinases.
Resolution1.94 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   225....230.........240.........250.........260.........270.........280.........290.........300....
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Query Sequence  DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYI
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Template Sequence  GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIK. . . . . . . EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFI
Template Known Secondary structure  GGGB

GGGSTTSS
TTT

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TT


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   393......400.........410.........420.........430... ......440.........450.........460.....
 
   305....310.........320.........330.........340.........350.........360.........370.........380....
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Query Sequence  ITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNE
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Template Sequence  ITEYMANGCLLNYLREM. RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGFP. . . . . . . .
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TT
G.GG


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S

SGGG
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   473......480......... 490.........500.........510.........520.........530.........540...
 
   385....390.........400.........410.........420.........430.........440.........450.........460....
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Query Sequence  DIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYN
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Template Sequence  . . . . . . . . . . . . VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYT
Template Known Secondary structure  ............GGG





TTS

TTTTS
TT





TTS
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   561........570.........580.........590.........600.........610.........620........
 
   465....470.........480.........490....
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Query Sequence  IMLECWNAEPKERPTFETLRWKLEDYFETD
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Template Sequence  IMYSCWHEKADERPTFKILLSNILDVMDEE
Template Known Secondary structure  TT
SSGGGS


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   629630.........640.........650........
 
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No model constructed - rank, confidence too low




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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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