Job Description P42685 Confidence 100.00% Date Tue Apr 3 14:35:51 BST 2012 Rank 3 Aligned Residues 437 % Identity 44% Template c1oplA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase Resolution 3.42 Å

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		45	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	Y	F	V	A	L	F	D	Y	Q	A	R	T	A	E	D	L	S	F	R	A	G	D	K	L	Q	V	L	D	T	L	H	E	G	W	W	F	A	R	H	L	E	K	R	R	D	G	S	S	Q	Q	L	Q	G	Y	I	P	S	N	Y	V	A	E	D	R	S	L	Q	A	E	P	W	F	F	G	A	I	G	R	S
Query Conservation
Alig confidence																																										.	.	.	.	.	.	.	.
Template Conservation																																										.	.	.	.	.	.	.	.
Template Sequence		N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	.	.	.	.	.	.	.	.	T	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N	S	L	E	K	H	S	W	Y	H	G	P	V	S	R	N
Template Known Secondary structure		T					S	S		B				S	T	T	B			B		T	T										T	T	S	S						.	.	.	.	.	.	.	.		S	S							G	G	G				S	S	S	G	G	G	S	T	T
Template Predicted Secondary structure																																										.	.	.	.	.	.	.	.
Template SS confidence
		83	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.									.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.
		125	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	A	E	K	Q	L	L	Y	S	E	N	K	T	G	S	F	L	I	R	E	S	E	S	Q	K	G	E	F	S	L	S	V	L	D	G	A	V	V	K	H	Y	R	I	K	R	L	D	E	G	G	F	F	L	T	R	R	R	I	F	S	T	L	N	E	F	V	S	H	Y	T	K	T	S	D	G	L	C	V	K	L
Query Conservation
Alig confidence								.	.
Template Conservation								.	.
Template Sequence		A	A	E	Y	L	L	.	.	S	S	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	E	G	R	V	Y	H	Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	I	T	T	L
Template Known Secondary structure							G	.	.	G	G			T	T								S	S	S	T	T									T	T											T	T	S				S	S	T	T	S		B	S	S									T	T			T	T	S	S	S
Template Predicted Secondary structure								.	.
Template SS confidence
		155	.	.	.	.	160			.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.
		205	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.		.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.
Predicted Secondary structure																																																					.
Query SS confidence																																																					.
Query Sequence		G	K	P	C	L	K	I	Q	V	P	A	P	F	D	L	S	Y	K	T	V	D	Q	W	E	I	D	R	N	S	I	Q	L	L	K	R	L	G	S	G	Q	F	G	E	V	W	E	G	L	W	N	N	.	T	T	P	V	A	V	K	T	L	K	P	G	S	M	D	P	N	D	F	L	R	E	A	Q	I	M	K	N
Query Conservation																																																					.
Alig confidence																			.																																		.
Template Conservation																			.
Template Sequence		H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	.	N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L	K	E	A	A	V	M	K	E
Template Known Secondary structure									S					S	S	S		S	.	S	S	S			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										S	S	S	S
Template Predicted Secondary structure																			.
Template SS confidence
		233	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.		250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.
		284	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	R	H	P	K	L	I	Q	L	Y	A	V	C	T	L	E	D	P	I	Y	I	I	T	E	L	M	R	H	G	S	L	Q	E	Y	L	Q	N	D	T	G	S	K	I	H	L	T	Q	Q	V	D	M	A	A	Q	V	A	S	G	M	A	Y	L	E	S	R	N	Y	I	H	R	D	L	A	A	R	N	V	L	V	G
Query Conservation
Alig confidence
Template Conservation
Template Sequence		I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C	L	V	G
Template Known Secondary structure					T	T	B									S	S	S	S									T	T		B								S		T	T	T	S																						T	T				S			S	G	G	G
Template Predicted Secondary structure
Template SS confidence
		312	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.
		364	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	H	N	I	Y	K	V	A	D	F	G	L	A	R	V	F	K	V	D	N	E	D	I	Y	E	S	R	H	E	I	K	L	P	V	K	W	T	A	P	E	A	I	R	S	N	K	F	S	I	K	S	D	V	W	S	F	G	I	L	L	Y	E	I	I	T	Y	G	K	M	P	Y	S	G	M	T	G	A	Q	V	I
Query Conservation
Alig confidence																						.	.	.
Template Conservation																						.	.	.
Template Sequence		E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	.	.	.	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y
Template Known Secondary structure		G	G	G							T	T						T	T			.	.	.					T	T					G	G	G																													T	T	S			S	S	T	T			T	T	T
Template Predicted Secondary structure																						.	.	.
Template SS confidence
		392	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.				.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.
		444	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	M	L	A	Q	N	Y	R	L	P	Q	P	S	N	C	P	Q	Q	F	Y	N	I	M	L	E	C	W	N	A	E	P	K	E	R	P	T	F	E	T	L	R	W	K	L	E	D	Y	F	E	T	D	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S
Template Known Secondary structure						T	T							T	T													T		S	S	G	G	G	S												T	S		S	S	S
Template Predicted Secondary structure
Template SS confidence
		469	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520