Job Description Q13882 Confidence 100.00% Date Wed May 9 17:41:40 BST 2012 Rank 53 Aligned Residues 259 % Identity 36% Template c3v5qB_ PDB info PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:nt-3 growth factor receptor; PDBTitle: discovery of a selective trk inhibitor with efficacy in rodent cancer2 tumor models Resolution 2.20 Å

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		184	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.		.	.	.	.	.	.	.	210	.		.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.
Predicted Secondary structure																					.										.
Query SS confidence																					.										.
Query Sequence		W	E	R	P	R	E	E	F	T	L	C	R	K	L	G	S	G	Y	F	.	G	E	V	F	E	G	L	W	K	.	D	R	V	Q	V	A	I	K	V	I	S	R	D	N	L	L	H	Q	Q	M	L	Q	S	E	I	Q	A	M	K	K	L	R	H	K	H	I	L	A	L	Y	A	V	V	S	V	G	D	P	V	Y
Query Conservation																					.										.
Alig confidence																					.										.																																															.	.
Template Conservation																																																																														.	.
Template Sequence		Q	H	I	K	R	R	D	I	V	L	K	R	E	L	G	F	K	V	F	L	A	E	C	Y	N	L	S	P	T	K	D	K	M	L	V	A	V	K	A	L	K	D	P	T	L	A	A	R	K	D	F	Q	R	E	A	E	L	L	T	N	L	Q	H	E	H	I	V	K	F	Y	G	V	C	G	D	P	.	.	L	I
Template Known Secondary structure						G	G	G																		S			S	S	S	S											S																						T	T	B											.	.
Template Predicted Secondary structure																																																																														.	.
Template SS confidence
		531	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.			.	.
		262	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	I	T	E	L	M	A	K	G	S	L	L	E	L	L	R	D	S	D	E	K	V	L	P	V	S	E	L	L	D	I	A	W	Q	V	A	E	G	M	C	Y	L	E	S	Q	N	Y	I	H	R	D	L	A	A	R	N	I	L	V	G	E	N	T	L	C	K	V	G	D	F	G	L	A	R	L	I	K	E	D	V
Query Conservation
Alig confidence																							.
Template Conservation																							.
Template Sequence		M	V	F	E	Y	M	K	H	G	D	L	N	K	F	L	R	A	H	G	P	E	.	L	G	L	S	Q	M	L	H	I	A	S	Q	I	A	S	G	M	V	Y	L	A	S	Q	H	F	V	H	R	D	L	A	T	R	N	C	L	V	G	A	N	L	L	V	K	I	G	D	F	G	M	D	V	Y	S	T	D	Y	Y
Template Known Secondary structure								T	T									T	T				.																							T	T				S			S	G	G	G					G	G	G												S	G	G	G		B
Template Predicted Secondary structure																							.
Template SS confidence
		615	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.		.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.
		342	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	L	S	H	D	H	N	I	P	Y	K	W	T	A	P	E	A	L	S	R	G	H	Y	S	T	K	S	D	V	W	S	F	G	I	L	L	H	E	M	F	S	R	G	Q	V	P	Y	P	G	M	S	N	H	E	A	F	L	R	V	D	A	G	Y	R	M	P	C	P	L	E	C	P	P	S	V	H	K	L	M	L
Query Conservation
Alig confidence			.	.	.	.
Template Conservation			.	.	.	.
Template Sequence		R	.	.	.	.	T	M	L	P	I	R	W	M	P	P	E	S	I	M	Y	R	K	F	T	T	E	S	D	V	W	S	F	G	V	I	L	W	E	I	F	T	Y	G	K	Q	P	W	F	Q	L	S	N	T	E	V	I	E	C	I	T	Q	G	R	V	L	E	R	P	R	V	C	P	K	E	V	Y	D	V	M	L
Template Known Secondary structure			.	.	.	.			B		G	G	G																												T	T	T	S			T	T	T	T	S												T							T	T
Template Predicted Secondary structure			.	.	.	.
Template SS confidence
		711					.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.
		422	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	C	W	C	R	D	P	E	Q	R	P	C	F	K	A	L	R	E	R	L	S	S	F	T	S	Y	E	N
Query Conservation
Alig confidence
Template Conservation
Template Sequence		G	C	W	Q	R	E	P	Q	Q	R	L	N	I	K	E	I	Y	K	I	L	H	A	L	G	K	A	T	P
Template Known Secondary structure						S	S	G	G	G	S																T
Template Predicted Secondary structure
Template SS confidence
		805	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions