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Job DescriptionQ13882
Confidence100.00%DateWed May 9 17:41:40 BST 2012
Rank80Aligned Residues243
% Identity38%Templatec3k54A_
PDB info PDB header:transferaseChain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: structures of human bruton's tyrosine kinase in active and inactive2 conformations suggests a mechanism of activation for tec family3 kinases.
Resolution1.94 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   181........190.........200.........210.........220.........230.........240.........250.........260
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Query Sequence  WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPV
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Template Sequence  YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKE. . . . . . . . FIEEAKVMMNLSHEKLVQLYGVCTKQRPI
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GGGB

GGGSTTSS
TTT


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TT


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   392.......400.........410.........420.........430.... .....440.........450.........460...
 
   261........270.........280.........290.........300.........310.........320.........330.........340
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Query Sequence  YIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKED
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Template Sequence  FIITEYMANGCLLNYLREM. RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGFP. . . . . .
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TT
G.GG


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S

SGGG
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   471........480......... 490.........500.........510.........520.........530.........540...
 
   341........350.........360.........370.........380.........390.........400.........410.........420
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Query Sequence  VYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM
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Template Sequence  . . . . . . . . . . VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM
Template Known Secondary structure  ..........GGG





TTS

TTTTS
TT





TTS
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   561........570.........580.........590.........600.........610.........620.........630
 
   421........430.........440........
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Query Sequence  LTCWCRDPEQRPCFKALRERLSSFTSYE
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Template Sequence  YSCWHEKADERPTFKILLSNILDVMDEE
Template Known Secondary structure  TT
SSGGGS


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   631........640.........650........
 
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No model constructed - rank, confidence too low




Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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