Job Description Q13882 Confidence 100.00% Date Wed May 9 17:41:40 BST 2012 Rank 4 Aligned Residues 434 % Identity 45% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å

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		13	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	V	G	L	W	D	F	K	S	R	T	D	E	E	L	S	F	R	A	G	D	V	F	H	V	A	R	K	E	E	Q	W	W	W	A	T	L	L	D	E	A	G	G	A	V	A	Q	G	Y	V	P	H	N	Y	L	A	E	R	E	T	V	E	S	E	P	W	F	F	G	C	I	S	R	S	E	A	V	R	R	L
Query Conservation
Alig confidence																																											.	.	.
Template Conservation																																											.	.	.
Template Sequence		F	V	A	L	Y	D	Y	E	S	R	T	E	T	D	L	S	F	K	K	G	E	R	L	Q	I	V	N	N	T	E	G	D	W	W	L	A	H	S	L	S	T	.	.	.	G	Q	T	G	Y	I	P	S	N	Y	V	A	P	S	D	S	I	Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E	R	L	L
Template Known Secondary structure					S	S		B				S	S	S	B			B		T	T									S	S	S	S							T	T	T	.	.	.								G	G	G				T	T	S	G	G	G	S	T	T	B			S
Template Predicted Secondary structure																																											.	.	.
Template SS confidence
		86	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.				.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
		93	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120						.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.
Predicted Secondary structure																														.	.	.	.	.
Query SS confidence																														.	.	.	.	.
Query Sequence		Q	A	E	G	N	A	T	G	A	F	L	I	R	V	S	E	K	P	S	A	D	Y	V	L	S	V	R	D	.	.	.	.	.	T	Q	A	V	R	H	Y	K	I	W	R	R	A	G	G	R	L	H	L	N	E	A	V	S	F	L	S	L	P	E	L	V	N	Y	H	R	A	Q	S	L	S	H	G	L	R	L	A
Query Conservation																														.	.	.	.	.
Alig confidence																														.	.	.	.	.
Template Conservation
Template Sequence		L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	K	G	A	Y	C	L	S	V	S	D	F	D	N	A	K	G	L	N	V	K	H	Y	K	I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S	L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H	R	L	T
Template Known Secondary structure		T		T	T			T	T								S	S	S	T	T											T	T	T										B		.			S						T	T				S	S													T	T	S	S	S
Template Predicted Secondary structure
Template SS confidence
		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
		168	.	170	.	.	.	.	.	.	.	.	.		180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.
Predicted Secondary structure														.
Query SS confidence														.
Query Sequence		A	P	C	R	K	H	E	P	E	P	L	P	.	H	W	D	D	W	E	R	P	R	E	E	F	T	L	C	R	K	L	G	S	G	Y	F	G	E	V	F	E	G	L	W	K	D	R	V	Q	V	A	I	K	V	I	S	R	D	N	L	L	H	Q	Q	M	L	Q	S	E	I	Q	A	M	K	K	L	R	H	K	H
Query Conservation														.
Alig confidence														.																																													.
Template Conservation																																																											.
Template Sequence		T	V	C	P	T	S	K	P	Q	T	Q	G	L	A	K	D	A	W	E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M	G	T	W	N	G	T	T	R	V	A	I	K	T	L	K	P	.	G	T	M	S	P	E	A	F	L	Q	E	A	Q	V	M	K	K	L	R	H	E	K
Template Known Secondary structure												S	S	S	S	T	T		S	B			G	G	G											S	S									T	T	T										T	.	T	S	S																		T	T
Template Predicted Secondary structure																																																											.
Template SS confidence
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.		300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.
		247	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	L	A	L	Y	A	V	V	S	V	G	D	P	V	Y	I	I	T	E	L	M	A	K	G	S	L	L	E	L	L	R	D	S	D	E	K	V	L	P	V	S	E	L	L	D	I	A	W	Q	V	A	E	G	M	C	Y	L	E	S	Q	N	Y	I	H	R	D	L	A	A	R	N	I	L	V	G	E	N	T	L	C
Query Conservation
Alig confidence											.
Template Conservation											.
Template Sequence		L	V	Q	L	Y	A	V	V	S	.	E	E	P	I	Y	I	V	T	E	Y	M	S	K	G	S	L	L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E	R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L	V	G	E	N	L	V	C
Template Known Secondary structure		B									.	S	S	S									T	T								S					T	T																							T	T				S			S	G	G	G					G	G	G
Template Predicted Secondary structure											.
Template SS confidence
		322	.	.	.	.	.	.	.	330		.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400
		327	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.		.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.
Predicted Secondary structure																					.
Query SS confidence																					.
Query Sequence		K	V	G	D	F	G	L	A	R	L	I	K	E	D	V	Y	L	S	H	.	D	H	N	I	P	Y	K	W	T	A	P	E	A	L	S	R	G	H	Y	S	T	K	S	D	V	W	S	F	G	I	L	L	H	E	M	F	S	R	G	Q	V	P	Y	P	G	M	S	N	H	E	A	F	L	R	V	D	A	G	Y	R
Query Conservation																					.
Alig confidence																					.
Template Conservation
Template Sequence		K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I	K	W	T	A	P	E	A	A	L	Y	G	R	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K	G	R	V	P	Y	P	G	M	V	N	R	E	V	L	D	Q	V	E	R	G	Y	R
Template Known Secondary structure						T	T	S	T	T	T								T	T		S	T	T	S		G	G	G	S																											T	T	T	T			S	S	T	T												T	T
Template Predicted Secondary structure
Template SS confidence
		401	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
		406	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.
Predicted Secondary structure
Query SS confidence
Query Sequence		M	P	C	P	L	E	C	P	P	S	V	H	K	L	M	L	T	C	W	C	R	D	P	E	Q	R	P	C	F	K	A	L	R	E	R	L	S	S	F	T	S	Y	E	N	P	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		M	P	C	P	P	E	C	P	E	S	L	H	D	L	M	C	Q	C	W	R	K	E	P	E	E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y	F	T	S	T	E	P	Q
Template Known Secondary structure						T	T													T		S	S	G	G	G	S												T	S	S				S
Template Predicted Secondary structure
Template SS confidence
		481	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.