Job Description Q13882 Confidence 100.00% Date Wed May 9 17:41:40 BST 2012 Rank 1 Aligned Residues 442 % Identity 36% Template c2fo0A_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase Resolution 2.27 Å

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		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80
Predicted Secondary structure
Query SS confidence
Query Sequence		M	V	S	R	D	Q	A	H	L	G	P	K	Y	V	G	L	W	D	F	K	S	R	T	D	E	E	L	S	F	R	A	G	D	V	F	H	V	A	R	K	E	E	Q	W	W	W	A	T	L	L	D	E	A	G	G	A	V	A	Q	G	Y	V	P	H	N	Y	L	A	E	R	E	T	V	E	S	E	P	W	F	F
Query Conservation
Alig confidence																																																						.	.	.	.
Template Conservation																																																						.	.	.	.
Template Sequence		L	L	A	G	P	S	E	N	D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	K	.	.	.	.	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N	S	L	E	K	H	S	W	Y	H
Template Known Secondary structure		T	T			G	G	G	S		T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							T	.	.	.	.	T							G	G	G				T	T	S	G	G	G	S	T	T
Template Predicted Secondary structure																																																						.	.	.	.
Template SS confidence
		73	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.					.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160
Predicted Secondary structure
Query SS confidence
Query Sequence		G	C	I	S	R	S	E	A	V	R	R	L	Q	A	E	G	N	A	T	G	A	F	L	I	R	V	S	E	K	P	S	A	D	Y	V	L	S	V	R	D	T	Q	A	V	R	H	Y	K	I	W	R	R	A	G	G	R	L	H	L	N	E	A	V	S	F	L	S	L	P	E	L	V	N	Y	H	R	A	Q	S	L
Query Conservation
Alig confidence																	.	.
Template Conservation																	.	.
Template Sequence		G	P	V	S	R	N	A	A	E	Y	L	L	S	S	G	.	.	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	E	G	R	V	Y	H	Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D
Template Known Secondary structure													T	S	S	S	.	.		T	T								S	S	S	T	T									T	T											T	T	S				S	S	T	T			B	S	S													T
Template Predicted Secondary structure																	.	.
Template SS confidence
		149	150	.	.	.	.	.	.	.	.	.	160	.	.	.			.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.
		161	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.					.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.		.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
Predicted Secondary structure																				.	.	.	.																																			.
Query SS confidence																				.	.	.	.																																			.
Query Sequence		S	H	G	L	R	L	A	A	P	C	R	K	H	E	P	E	P	L	.	.	.	.	P	H	W	D	D	W	E	R	P	R	E	E	F	T	L	C	R	K	L	G	S	G	Y	F	G	E	V	F	E	G	L	W	K	D	.	R	V	Q	V	A	I	K	V	I	S	R	D	N	L	L	H	Q	Q	M	L	Q	S	E
Query Conservation																				.	.	.	.																																			.
Alig confidence																				.	.	.	.																																			.												.
Template Conservation																																																																						.
Template Sequence		G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	.	D	T	M	E	V	E	E	F	L	K	E
Template Known Secondary structure		T	S	S	S															S	S	S		S	S	T	T			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										T	.	T	S
Template Predicted Secondary structure																																																																						.
Template SS confidence
		227	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.		.	.	.	.	.	300	.	.	.	.	.
		236	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	Q	A	M	K	K	L	R	H	K	H	I	L	A	L	Y	A	V	V	S	V	G	D	P	V	Y	I	I	T	E	L	M	A	K	G	S	L	L	E	L	L	R	D	S	D	E	K	V	L	P	V	S	E	L	L	D	I	A	W	Q	V	A	E	G	M	C	Y	L	E	S	Q	N	Y	I	H	R	D	L	A	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	A	V	M	K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A
Template Known Secondary structure											T	T	B									S	S	S	S									T	T		B								S		T	T	T	S																						T	T				S			S	G
Template Predicted Secondary structure
Template SS confidence
		306	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.
		316	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.		.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.
Predicted Secondary structure																																.
Query SS confidence																																.
Query Sequence		R	N	I	L	V	G	E	N	T	L	C	K	V	G	D	F	G	L	A	R	L	I	K	E	D	V	Y	L	S	H	.	D	H	N	I	P	Y	K	W	T	A	P	E	A	L	S	R	G	H	Y	S	T	K	S	D	V	W	S	F	G	I	L	L	H	E	M	F	S	R	G	Q	V	P	Y	P	G	M	S	N	H
Query Conservation																																.
Alig confidence																																.
Template Conservation
Template Sequence		R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S
Template Known Secondary structure		G	G					G	G	G							T	T						S	S							T	T					G	G	G																													T	T	S			S	S	T	T
Template Predicted Secondary structure
Template SS confidence
		386	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.
		395	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	A	F	L	R	V	D	A	G	Y	R	M	P	C	P	L	E	C	P	P	S	V	H	K	L	M	L	T	C	W	C	R	D	P	E	Q	R	P	C	F	K	A	L	R	E	R	L	S	S	F	T	S	Y	E	N
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Q	V	Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S
Template Known Secondary structure									T	T							T	T													T		S	S	G	G	G	S												T	S	S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		466	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520