Phyre 2 Results for Q8NBR0

Email	l.a.kelley@imperial.ac.uk
Description	Q8NBR0
Date	Wed Jun 6 09:32:45 BST 2012
Unique Job ID	cf4e8fe59ea7199b

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template d1k3ra2

Top template information

Fold:alpha/beta knot
Superfamily:alpha/beta knot
Family:Hypothetical protein MTH1 (MT0001), dimerisation domain

Confidence and coverage

Confidence:

82.0%

Coverage:

19 residues ( 5% of your sequence) have been modelled with 82.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Please note: You must be registered and logged in to use Phyrealarm.

Warning: 53% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A P P P P S P Q L L L L A A L A R L L G P S E V M A G P A E E A G A H C P E S L W P L P P Q V S P R V T Y T R V S P G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
? ? ?
? ? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence Q A E D V T F L Y H P C A H P W L K L Q L A L L A Y A C M A N P S L T P D F S L T Q D R P L V L T A W G L A L E M A W V

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence E P A W A A H W L M R R R R R K Q R K K K A W I Y C E S L S G P A P S E P T P G R G R L C R R G C V Q A L A L A F A L R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence S W R P P G T E V T S Q G P R Q P S S S G A K R R R L R A A L G P Q P T R S A L R F P S A S P G S L K A K Q S M A G I P

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence G R E S N A P S V P T V S L L P G A P G G N A S S R T E A Q V P N G Q G S P G G C V C S S Q A S P A P R A A A P P R A A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence R G P T P R T E E A A W A A M A L T F L L V L L T L A T L C T R L H R N F R R G E S I Y W G P T A D S Q D T V A A V L K

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . .

Sequence R R L L Q P S R R V K R S R R R P L L P P T P D S G P E G E S S E

Secondary structure

SS confidence

Disorder
?
? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1k3r chain A domain 2

Region: 304 - 322
Aligned: 19
Modelled: 19
Confidence: 82.0%
Identity: 42%
Fold: alpha/beta knot
Superfamily: alpha/beta knot
Family: Hypothetical protein MTH1 (MT0001), dimerisation domain

Phyre2

PDB 1k3r chain A

Region: 304 - 321
Aligned: 18
Modelled: 18
Confidence: 69.6%
Identity: 44%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:conserved protein mt0001;
PDBTitle: crystal structure of the methyltransferase with a knot from2 methanobacterium thermoautotrophicum

Phyre2

PDB 1x93 chain B

Region: 339 - 370
Aligned: 32
Modelled: 32
Confidence: 56.3%
Identity: 25%
PDB header:transcription
Chain: B: PDB Molecule:hypothetical protein hp0222;
PDBTitle: nmr structure of helicobacter pylori hp0222

Phyre2

PDB 2ok5 chain A domain 4

Region: 36 - 47
Aligned: 12
Modelled: 32
Confidence: 51.7%
Identity: 42%
Fold: Complement control module/SCR domain
Superfamily: Complement control module/SCR domain
Family: Complement control module/SCR domain

Phyre2

PDB 1x93 chain A domain 1

Region: 339 - 370
Aligned: 32
Modelled: 32
Confidence: 40.8%
Identity: 25%
Fold: Ribbon-helix-helix
Superfamily: Ribbon-helix-helix
Family: CopG-like

Phyre2

PDB 2nrz chain B

Region: 334 - 384
Aligned: 32
Modelled: 32
Confidence: 28.1%
Identity: 28%
PDB header:hydrolase
Chain: B: PDB Molecule:uvrabc system protein c;
PDBTitle: crystal structure of the c-terminal half of uvrc bound to2 its catalytic divalent cation

Phyre2

PDB 2fwt chain A

Region: 37 - 64
Aligned: 28
Modelled: 28
Confidence: 27.6%
Identity: 14%
PDB header:electron transport
Chain: A: PDB Molecule:dhc, diheme cytochrome c;
PDBTitle: crystal structure of dhc purified from rhodobacter2 sphaeroides

Phyre2

PDB 2nrr chain A

Region: 334 - 384
Aligned: 27
Modelled: 28
Confidence: 23.7%
Identity: 37%
PDB header:hydrolase
Chain: A: PDB Molecule:uvrabc system protein c;
PDBTitle: crystal structure of the c-terminal rnaseh endonuclase2 domain of uvrc

Phyre2

PDB 3ml6 chain D

Region: 112 - 149
Aligned: 37
Modelled: 38
Confidence: 22.0%
Identity: 16%
PDB header:protein transport
Chain: D: PDB Molecule:chimeric complex between protein dishevlled2 homolog dvl-2
PDBTitle: a complex between dishevlled2 and clathrin adaptor ap-2

Phyre2

PDB 3eop chain B

Region: 61 - 70
Aligned: 10
Modelled: 38
Confidence: 20.7%
Identity: 30%
PDB header:unknown function
Chain: B: PDB Molecule:thymocyte nuclear protein 1;
PDBTitle: crystal structure of the duf55 domain of human thymocyte nuclear2 protein 1

Phyre2

PDB 2gbs chain A domain 1

Region: 61 - 70
Aligned: 10
Modelled: 10
Confidence: 20.5%
Identity: 40%
Fold: PUA domain-like
Superfamily: PUA domain-like
Family: Atu2648/PH1033-like

Phyre2

PDB 1zce chain A domain 1

Region: 61 - 70
Aligned: 10
Modelled: 10
Confidence: 20.4%
Identity: 40%
Fold: PUA domain-like
Superfamily: PUA domain-like
Family: Atu2648/PH1033-like

Phyre2

PDB 2g2x chain A domain 1

Region: 61 - 70
Aligned: 10
Modelled: 10
Confidence: 19.7%
Identity: 40%
Fold: PUA domain-like
Superfamily: PUA domain-like
Family: Atu2648/PH1033-like

Phyre2

PDB 2ar1 chain A domain 1

Region: 61 - 70
Aligned: 10
Modelled: 10
Confidence: 18.2%
Identity: 30%
Fold: PUA domain-like
Superfamily: PUA domain-like
Family: Atu2648/PH1033-like

Phyre2

PDB 2eve chain A domain 1

Region: 61 - 70
Aligned: 10
Modelled: 10
Confidence: 18.0%
Identity: 40%
Fold: PUA domain-like
Superfamily: PUA domain-like
Family: Atu2648/PH1033-like

Phyre2

PDB 1q90 chain N

Region: 311 - 323
Aligned: 13
Modelled: 13
Confidence: 16.8%
Identity: 38%
Fold: Single transmembrane helix
Superfamily: PetN subunit of the cytochrome b6f complex
Family: PetN subunit of the cytochrome b6f complex

Phyre2

PDB 3c65 chain A

Region: 334 - 363
Aligned: 26
Modelled: 30
Confidence: 15.5%
Identity: 19%
PDB header:hydrolase
Chain: A: PDB Molecule:uvrabc system protein c;
PDBTitle: crystal structure of bacillus stearothermophilus uvrc 5'2 endonuclease domain

Phyre2

PDB 1y5i chain A domain 1

Region: 56 - 70
Aligned: 15
Modelled: 15
Confidence: 15.4%
Identity: 33%
Fold: Double psi beta-barrel
Superfamily: ADC-like
Family: Formate dehydrogenase/DMSO reductase, C-terminal domain

Phyre2

PDB 2jy0 chain A

Region: 308 - 327
Aligned: 20
Modelled: 20
Confidence: 14.6%
Identity: 55%
PDB header:membrane protein, viral protein
Chain: A: PDB Molecule:protease ns2-3;
PDBTitle: solution nmr structure of hcv ns2 protein, membrane segment2 (1-27)

Phyre2

PDB 4a8x chain B

Region: 329 - 352
Aligned: 24
Modelled: 24
Confidence: 11.9%
Identity: 29%
PDB header:transcription
Chain: B: PDB Molecule:hook-like, isoform a;
PDBTitle: structure of the core asap complex

Phyre2