Job Description Q08881 Confidence 100.00% Date Tue Apr 3 14:36:05 BST 2012 Rank 3 Aligned Residues 435 % Identity 36% Template c1oplA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase Resolution 3.42 Å

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		172	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	E	T	V	V	I	A	L	Y	D	Y	Q	T	N	D	P	Q	E	L	A	L	R	R	N	E	E	Y	C	L	L	D	S	S	E	I	H	W	W	R	V	Q	D	R	N	G	H	E	G	Y	V	P	S	S	Y	L	V	E	K	S	P	N	N	L	E	T	Y	E	W	Y	N	K	S	I	S	R	D	K	A	E	K
Query Conservation
Alig confidence																																																												.	.
Template Conservation																																																												.	.
Template Sequence		D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	.	.	N	S	L	E	K	H	S	W	Y	H	G	P	V	S	R	N	A	A	E	Y
Template Known Secondary structure			T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							S	S							G	G	G				S	.	.	S	S	G	G	G	S	T	T
Template Predicted Secondary structure																																																												.	.
Template SS confidence
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.			.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.
		252	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.		270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330
Predicted Secondary structure																				.
Query SS confidence																				.
Query Sequence		L	L	L	D	T	G	K	E	G	A	F	M	V	R	D	S	R	T	.	A	G	T	Y	T	V	S	V	F	T	K	A	V	V	S	E	N	N	P	C	I	K	H	Y	H	I	K	E	T	N	D	N	P	K	R	Y	Y	V	A	E	K	Y	V	F	D	S	I	P	L	L	I	N	Y	H	Q	H	N	G	G	G	L
Query Conservation																				.
Alig confidence							.													.											.	.	.	.	.	.	.																.	.
Template Conservation							.																								.	.	.	.	.	.	.																.	.
Template Sequence		L	L	S	S	G	.	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	.	.	.	.	.	.	.	E	G	R	V	Y	H	Y	R	I	N	T	A	S	D	G	.	.	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L
Template Known Secondary structure			G	G	G		.		T	T								S	S	S	T	T									.	.	.	.	.	.	.	T	T											T	T	S	.	.				S	S	T	T	S		B	S	S									T	T			T	T	S
Template Predicted Secondary structure							.																								.	.	.	.	.	.	.																.	.
Template SS confidence
		159	160	.	.	.		.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.								.	.	.	190	.	.	.	.	.	.	.	.	.	200	.			.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.
		331	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.		.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																								.
Query SS confidence																																																								.
Query Sequence		V	T	R	L	R	Y	P	V	C	F	G	R	Q	K	A	P	V	T	A	G	L	R	Y	G	K	W	V	I	D	P	S	E	L	T	F	V	Q	E	I	G	S	G	Q	F	G	L	V	H	L	G	Y	W	L	N	.	K	D	K	V	A	I	K	T	I	R	E	G	A	M	S	E	E	D	F	I	E	E	A	E	V
Query Conservation																																																								.
Alig confidence																																																								.
Template Conservation
Template Sequence		I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L	K	E	A	A	V
Template Known Secondary structure		S	S										S					S	S	S		S	S	S	S			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		229	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.
		410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.		.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.
Predicted Secondary structure																																													.
Query SS confidence																																													.
Query Sequence		M	M	K	L	S	H	P	K	L	V	Q	L	Y	G	V	C	L	E	Q	A	P	I	C	L	V	F	E	F	M	E	H	G	C	L	S	D	Y	L	R	T	Q	R	G	.	L	F	A	A	E	T	L	L	G	M	C	L	D	V	C	E	G	M	A	Y	L	E	E	A	C	V	I	H	R	D	L	A	A	R	N	C
Query Conservation																																													.
Alig confidence																																													.
Template Conservation
Template Sequence		M	K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C
Template Known Secondary structure								T	T	B									S	S	S	S									T	T		B								S		T	T	T	S																						T	T				S			S	G	G	G
Template Predicted Secondary structure
Template SS confidence
		309	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.
		489	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	V	G	E	N	Q	V	I	K	V	S	D	F	G	M	T	R	F	V	L	D	D	Q	Y	T	S	S	T	G	T	K	F	P	V	K	W	A	S	P	E	V	F	S	F	S	R	Y	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	V	F	S	E	G	K	I	P	Y	E	N	R	S	N	S	E	V	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y
Template Known Secondary structure					G	G	G							T	T						T	T							T	T					G	G	G																													T	T	S			S	S	T	T			T	T	T
Template Predicted Secondary structure
Template SS confidence
		389	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.
		569	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	D	I	S	T	G	F	R	L	Y	K	P	R	L	A	S	T	H	V	Y	Q	I	M	N	H	C	W	K	E	R	P	E	D	R	P	A	F	S	R	L	L	R	Q	L	A	E	I	A	E	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E
Template Known Secondary structure						T	T							T	T													T		S	S	G	G	G	S												T	S		S	S
Template Predicted Secondary structure
Template SS confidence
		469	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.