Job Description Q06124 Confidence 100.00% Date Wed May 9 17:40:46 BST 2012 Rank 2 Aligned Residues 501 % Identity 60% Template c2b3oA_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 Resolution 2.80 Å

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		5	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	W	F	H	P	N	I	T	G	V	E	A	E	N	L	L	L	T	R	G	V	D	G	S	F	L	A	R	P	S	K	S	N	P	G	D	F	T	L	S	V	R	R	N	G	A	V	T	H	I	K	I	Q	N	T	G	D	Y	Y	D	L	Y	G	G	E	K	F	A	T	L	A	E	L	V	Q	Y	Y	M	E	H
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	W	F	H	R	D	L	S	G	L	D	A	E	T	L	L	K	G	R	G	V	H	G	S	F	L	A	R	P	S	R	K	N	Q	G	D	F	S	L	S	V	R	V	G	D	Q	V	T	H	I	R	I	Q	N	S	G	D	F	Y	D	L	Y	G	G	E	K	F	A	T	L	T	E	L	V	E	Y	Y	T	Q	Q
Template Known Secondary structure		T	T	B		S	S																T	T								S	S	S	S	S									T	T										S	S	S					T	T	S				S											T	T
Template Predicted Secondary structure
Template SS confidence
		3	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.
		85	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	G	Q	L	K	E	K	N	G	D	V	I	E	L	K	Y	P	L	N	C	A	D	P	T	S	E	R	W	F	H	G	H	L	S	G	K	E	A	E	K	L	L	T	E	K	G	K	H	G	S	F	L	V	R	E	S	Q	S	H	P	G	D	F	V	L	S	V	R	T	G	D	D	K	G	E	S	N	D	G	K
Query Conservation
Alig confidence																																																																											.	.	.	.	.
Template Conservation																																																																											.	.	.	.	.
Template Sequence		Q	G	V	L	Q	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	C	S	D	P	T	S	E	R	W	Y	H	G	H	M	S	G	G	Q	A	E	T	L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F	V	L	S	V	L	S	D	Q	P	K	.	.	.	.	.	S	P
Template Known Secondary structure			S		B			S	S	S			B											G	G	G		T	T	B		T	T																T	T								S	S	S	T	T													.	.	.	.	.
Template Predicted Secondary structure																																																																											.	.	.	.	.
Template SS confidence
		83	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.						.	.
		165	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	K	V	T	H	V	M	I	R	C	Q	E	L	K	Y	D	V	G	G	G	E	R	F	D	S	L	T	D	L	V	E	H	Y	K	K	N	P	M	V	E	T	L	G	T	V	L	Q	L	K	Q	P	L	N	T	T	R	I	N	A	A	E	I	E	S	R	V	R	E	L	S	K	L	A	E	T	T	D	K	V	K
Query Conservation
Alig confidence																																																																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																																																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		L	R	V	T	H	I	K	V	M	C	E	G	G	R	Y	T	V	G	G	L	E	T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	S	G	A	F	V	Y	L	R	Q	P	Y	Y	A	T	R	V	N	A	A	D	I	E	N	R	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure										B			T	T	S	B	B	S	S	S	S			B	S	S																S	S	S																	G	G	G	T			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																																																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		162	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.
		245	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	G	F	W	E	E	F	E	T	L	Q	Q	Q	E	C	K	L	L	Y	S	R	K	E	G	Q	R	Q	E	N	K	N	K	N	R	Y	K	N	I	L	P	F	D	H	T	R	V	V	L	H	D	G	D	P	N	E	P	V	S	D	Y	I	N	A	N	I	I	M	P	E	F	E	T	K	C	N	N	S	K	P	K
Query Conservation
Alig confidence		.	.																																																																						.	.	.
Template Conservation		.	.																																																																						.	.	.
Template Sequence		.	.	F	W	E	E	F	E	S	L	Q	K	Q	E	V	K	N	L	H	Q	R	L	E	G	Q	R	P	E	N	K	G	K	N	R	Y	K	N	I	L	P	F	D	H	S	R	V	I	L	Q	G	R	D	S	N	I	P	G	S	D	Y	I	N	A	N	Y	I	K	N	Q	L	L	.	.	.	G	P	D	E	N	A
Template Known Secondary structure		.	.										T	T	T	T	T	T						G	G	G	S	T	T	G	G	G	G		S	S	T	T					T	T	T	B				S	S			T	T	S	S	S		S			S							T	T	S	.	.	.		T	T	S
Template Predicted Secondary structure		.	.																																																																						.	.	.
Template SS confidence
				244	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.				.	.	.	.	.	.
		325	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	S	Y	I	A	T	Q	G	C	L	Q	N	T	V	N	D	F	W	R	M	V	F	Q	E	N	S	R	V	I	V	M	T	T	K	E	V	E	R	G	K	S	K	C	V	K	Y	W	P	D	E	Y	A	L	K	E	Y	G	V	M	R	V	R	N	V	K	E	S	A	A	H	D	Y	T	L	R	E	L	K	L	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		K	T	Y	I	A	S	Q	G	C	L	E	A	T	V	N	D	F	W	Q	M	A	W	Q	E	N	S	R	V	I	V	M	T	T	R	E	V	E	K	G	R	N	K	C	V	P	Y	W	P	E	V	G	M	Q	R	A	Y	G	P	Y	S	V	T	N	C	G	E	H	D	T	T	E	Y	K	L	R	T	L	Q	V	S
Template Known Secondary structure												T	T	T												T								S		S			T	T								S			T	T						S	S												S	S
Template Predicted Secondary structure
Template SS confidence
		319	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.
		405	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	V	G	Q	A	L	L	Q	G	N	T	E	R	T	V	W	Q	Y	H	F	R	T	W	P	D	H	G	V	P	S	D	P	G	G	V	L	D	F	L	E	E	V	H	H	K	Q	E	S	I	M	D	A	G	P	V	V	V	H	C	S	A	G	I	G	R	T	G	T	F	I	V	I	D	I	L	I	D	I	I	R
Query Conservation
Alig confidence					.	.	.	.
Template Conservation					.	.	.	.
Template Sequence		P	L	D	.	.	.	.	N	G	D	L	I	R	E	I	W	H	Y	Q	Y	L	S	W	P	D	H	G	V	P	S	E	P	G	G	V	L	S	F	L	D	Q	I	N	Q	R	Q	E	S	L	P	H	A	G	P	I	I	V	H	C	S	A	G	I	G	R	T	G	T	I	I	V	I	D	M	L	M	E	N	I	S
Template Known Secondary structure			G	G	.	.	.	.	G	T	T															S	S	S			S	S	S																	S	T	T									S	S	S	S	S
Template Predicted Secondary structure					.	.	.	.
Template SS confidence
		399	400	.					.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.
		485	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	K	G	V	D	C	D	I	D	V	P	K	T	I	Q	M	V	R	S	Q	R	S	G	M	V	Q	T	E	A	Q	Y	R	F	I	Y	M	A	V	Q	H	Y	I	E	T	L	Q	R	R	I	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		T	K	G	L	D	C	D	I	D	I	Q	K	T	I	Q	M	V	R	A	Q	R	S	G	M	V	Q	T	E	A	Q	Y	K	F	I	Y	V	A	I	A	Q	F	I	E	T	T	K	K	K	L	E
Template Known Secondary structure			S		T	T	S												T	T	T	S	T	T	S	S		S																			T		S
Template Predicted Secondary structure
Template SS confidence
		475	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.