Job Description Q06124 Confidence 100.00% Date Wed May 9 17:40:46 BST 2012 Rank 46 Aligned Residues 200 % Identity 31% Template c1a81E_ PDB info PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam Resolution 3.00 Å

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		3	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.		.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.		60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80
Predicted Secondary structure																									.																																			.
Query SS confidence																									.																																			.
Query Sequence		S	R	R	W	F	H	P	N	I	T	G	V	E	A	E	N	L	L	L	T	R	G	V	.	D	G	S	F	L	A	R	P	S	K	S	N	P	G	D	F	T	L	S	V	R	R	N	G	A	V	T	H	I	K	I	Q	N	T	.	G	D	Y	Y	D	L	Y	G	G	E	K	F	A	T	L	A	E	L	V	Q	Y
Query Conservation																									.																																			.
Alig confidence																									.																																			.
Template Conservation
Template Sequence		H	L	P	F	F	F	G	N	I	T	R	E	E	A	E	D	Y	L	V	Q	G	G	M	S	D	G	L	Y	L	L	R	Q	S	R	N	Y	L	G	G	F	A	L	S	V	A	H	G	R	K	A	H	H	Y	T	I	E	R	E	L	N	G	T	Y	A	I	A	G	G	R	T	H	A	S	P	A	D	L	C	H	Y
Template Known Secondary structure		G		T	T			S	S												T	T	T			T	T								S	S	S	T	T									S	S	S										T	T	T					T	T	S			B	S	S
Template Predicted Secondary structure
Template SS confidence
		12	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.												.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.		.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.
Predicted Secondary structure																													.	.	.	.	.	.	.	.	.	.	.																									.
Query SS confidence																													.	.	.	.	.	.	.	.	.	.	.																									.
Query Sequence		Y	M	E	H	H	G	Q	L	K	E	K	N	G	D	V	I	E	L	K	Y	P	L	N	C	A	D	P	.	.	.	.	.	.	.	.	.	.	.	T	S	E	R	W	F	H	G	H	L	S	G	K	E	A	E	K	L	L	T	E	K	G	K	.	H	G	S	F	L	V	R	E	S	Q	S	H	P	G	D	F	V
Query Conservation																													.	.	.	.	.	.	.	.	.	.	.																									.
Alig confidence																													.	.	.	.	.	.	.	.	.	.	.																									.										.
Template Conservation																																																																										.
Template Sequence		H	S	Q	E	S	D	G	L	V	C	L	L	K	K	P	F	N	R	P	Q	G	V	Q	P	K	T	P	Q	L	E	K	L	I	A	T	T	A	H	E	K	M	P	W	F	H	G	K	I	S	R	E	E	S	E	Q	I	V	L	I	G	S	K	T	N	G	K	F	L	I	R	A	R	.	D	N	N	G	S	Y	A
Template Known Secondary structure			T	T			T	T	S	S	S				S	B					T	T															T	S	G	G	G		T	T																S	S				T	T								.	S	S	S	S
Template Predicted Secondary structure																																																																										.
Template SS confidence
		92	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.		.	.	.	.	.	.	170
		149	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.		.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.
Predicted Secondary structure																													.
Query SS confidence																													.
Query Sequence		L	S	V	R	T	G	D	D	K	G	E	S	N	D	G	K	S	K	V	T	H	V	M	I	R	C	Q	.	E	L	K	Y	D	V	G	G	G	E	R	F	D	S	L	T	D	L	V	E	H	Y	K	K	N	P	M	V	E	T	L	G	T	V	L	Q	L	K	Q	P	L	N
Query Conservation																													.
Alig confidence							.	.	.	.	.	.	.	.	.	.													.																											.	.	.	.
Template Conservation							.	.	.	.	.	.	.	.	.	.																																								.	.	.	.
Template Sequence		L	C	L	L	H	.	.	.	.	.	.	.	.	.	.	E	G	K	V	L	H	Y	R	I	D	K	D	K	T	G	K	L	S	I	P	E	G	K	K	F	D	T	L	W	Q	L	V	E	H	Y	S	Y	K	A	.	.	.	.	D	G	L	L	R	V	L	T	V	P	C	Q
Template Known Secondary structure							.	.	.	.	.	.	.	.	.	.	T	T											T	T	S					T	T	S			B	S										T	T			.	.	.	.	T	T	S	S	S				S	B
Template Predicted Secondary structure							.	.	.	.	.	.	.	.	.	.																																								.	.	.	.
Template SS confidence
		205	.	.	.	.											210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.					.	250	.	.	.	.	.	.	.	.	.	260

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions