Email l.a.kelley@imperial.ac.uk Description O75791 Date Wed May 9 17:39:07 BST 2012 Unique Job ID 98b238c746de9cd9

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1griA_ 100.0 60 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 2 c2lqnA_ 100.0 25 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 3 c2l3sA_ 100.0 26 PDB header:structural protein Chain: A: PDB Molecule:autoinhibited crk protein; PDBTitle: structure of the autoinhibited crk 4 c2eyzA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 5 c1ng2A_ 100.0 32 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosolic factor 1; PDBTitle: structure of autoinhibited p47phox 6 c1ov3A_ 100.0 33 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosol factor 1; PDBTitle: structure of the p22phox-p47phox complex 7 c1mv3A_ 99.9 13 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc 8 c2eyyA_ 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 9 d1ng2a2 99.8 24 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 10 c1k9aB_ 99.8 34 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 11 c1oplA_ 99.8 33 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 12 c2fo0A_ 99.8 36 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 13 c2c0iA_ 99.8 38 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 14 c2dx1A_ 99.8 44 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4; PDBTitle: crystal structure of rhogef protein asef 15 c1x27F_ 99.8 38 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 16 c2dybA_ 99.8 32 PDB header:oxidoreductase Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: the crystal structure of human p40(phox) 17 c2dvjA_ 99.8 29 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 18 c2cubA_ 99.8 23 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1 19 c1y57A_ 99.8 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 20 c2h8hA_ 99.8 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 21 d1ov3a2 not modelled 99.8 25 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 22 c3nmzD_ not modelled 99.8 36 PDB header:cell adhesion/cell cycle Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4; PDBTitle: crytal structure of apc complexed with asef 23 c2fpeB_ not modelled 99.8 25 PDB header:signaling protein Chain: B: PDB Molecule:c-jun-amino-terminal kinase interacting protein PDBTitle: conserved dimerization of the ib1 src-homology 3 domain 24 c2dmoA_ not modelled 99.8 29 PDB header:signaling protein Chain: A: PDB Molecule:neutrophil cytosol factor 2; PDBTitle: refined solution structure of the 1st sh3 domain from human2 neutrophil cytosol factor 2 (ncf-2) 25 c2ed0A_ not modelled 99.8 25 PDB header:signaling protein Chain: A: PDB Molecule:abl interactor 2; PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2) 26 c2df6A_ not modelled 99.8 33 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7; PDBTitle: crystal structure of the sh3 domain of betapix in complex2 with a high affinity peptide from pak2 27 c2ablA_ not modelled 99.8 37 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 28 c2yunA_ not modelled 99.8 37 PDB header:protein transport Chain: A: PDB Molecule:nostrin; PDBTitle: solution structure of the sh3 domain of human nostrin 29 d1sema_ not modelled 99.8 41 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 30 c2xmfA_ not modelled 99.8 37 PDB header:motor protein Chain: A: PDB Molecule:myosin 1e sh3; PDBTitle: myosin 1e sh3 31 c1zx6A_ not modelled 99.8 38 PDB header:protein binding Chain: A: PDB Molecule:ypr154wp; PDBTitle: high-resolution crystal structure of yeast pin3 sh3 domain 32 c2yuoA_ not modelled 99.8 33 PDB header:signaling protein Chain: A: PDB Molecule:run and tbc1 domain containing 3; PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3 33 c2yt6A_ not modelled 99.8 28 PDB header:cell cycle Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full- PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1 34 c2rqrA_ not modelled 99.8 13 PDB header:protein binding Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex 35 d1utia_ not modelled 99.8 96 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 36 c2bz8B_ not modelled 99.8 25 PDB header:sh3 domain Chain: B: PDB Molecule:sh3-domain kinase binding protein 1; PDBTitle: n-terminal sh3 domain of cin85 bound to cbl-b peptide 37 d1gria2 not modelled 99.8 46 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 38 d1oeba_ not modelled 99.8 92 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 39 c2dlpA_ not modelled 99.8 27 PDB header:structural protein Chain: A: PDB Molecule:kiaa1783 protein; PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein 40 c3nhnA_ not modelled 99.8 38 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 41 c2dl4A_ not modelled 99.8 30 PDB header:signaling protein Chain: A: PDB Molecule:protein stac; PDBTitle: solution structure of the first sh3 domain of stac protein 42 d1gcqa_ not modelled 99.8 48 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 43 c1x2qA_ not modelled 99.8 41 PDB header:signaling protein Chain: A: PDB Molecule:signal transducing adapter molecule 2; PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2 44 d1uuea_ not modelled 99.8 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 45 d1wlpb2 not modelled 99.8 28 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 46 c2nwmA_ not modelled 99.8 36 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin 47 c2dilA_ not modelled 99.8 28 PDB header:cell adhesion Chain: A: PDB Molecule:proline-serine-threonine phosphatase-interacting PDBTitle: solution structure of the sh3 domain of the human proline-2 serine-threonine phosphatase-interacting protein 1 48 c2ct3A_ not modelled 99.8 32 PDB header:signaling protein Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the sh3 domain of the vinexin protein 49 c2djqA_ not modelled 99.8 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sh3 domain containing ring finger 2; PDBTitle: the solution structure of the first sh3 domain of mouse sh32 domain containing ring finger 2 50 c2oi3A_ not modelled 99.8 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1) 51 d1pwta_ not modelled 99.8 28 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 52 c2pqhA_ not modelled 99.8 28 PDB header:structural protein Chain: A: PDB Molecule:spectrin alpha chain, brain; PDBTitle: structure of sh3 chimera with a type ii ligand linked to the chain c-2 terminal 53 c2csqA_ not modelled 99.8 24 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:rim binding protein 2; PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2 54 c2dl3A_ not modelled 99.8 29 PDB header:cell adhesion, signaling protein Chain: A: PDB Molecule:sorbin and sh3 domain-containing protein 1; PDBTitle: solution structure of the first sh3 domain of human sorbin2 and sh3 domain-containing protein 1 55 d1k4us_ not modelled 99.8 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 56 c2l0aA_ not modelled 99.8 46 PDB header:signaling protein Chain: A: PDB Molecule:signal transducing adapter molecule 1; PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e 57 d1udla_ not modelled 99.8 30 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 58 c2kymA_ not modelled 99.8 31 PDB header:signaling protein Chain: A: PDB Molecule:bud emergence protein 1; PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide 59 c2cudA_ not modelled 99.8 18 PDB header:signaling protein Chain: A: PDB Molecule:src-like-adapter; PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap) 60 c2epdA_ not modelled 99.8 24 PDB header:protein binding Chain: A: PDB Molecule:rho gtpase-activating protein 4; PDBTitle: solution structure of sh3 domain in rho-gtpase-activating2 protein 4 61 c2ysqA_ not modelled 99.8 32 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9; PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9 62 d1j3ta_ not modelled 99.8 25 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 63 c2dnuA_ not modelled 99.8 25 PDB header:structural genomics, structural protein Chain: A: PDB Molecule:sh3 multiple domains 1; PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human 64 c2jxbA_ not modelled 99.8 24 PDB header:signaling protein complex Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain, PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex 65 c2ebpA_ not modelled 99.8 26 PDB header:cell adhesion Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1; PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1 66 d1e6ga_ not modelled 99.8 26 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 67 d1u06a1 not modelled 99.8 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 68 d1ue9a_ not modelled 99.8 23 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 69 c2drmB_ not modelled 99.8 40 PDB header:contractile protein Chain: B: PDB Molecule:acanthamoeba myosin ib; PDBTitle: acanthamoeba myosin i sh3 domain bound to acan125 70 c1wi7A_ not modelled 99.8 27 PDB header:protein binding Chain: A: PDB Molecule:sh3-domain kinase binding protein 1; PDBTitle: solution structure of the sh3 domain of sh3-domain kinase2 binding protein 1 71 c1x69A_ not modelled 99.8 29 PDB header:signaling protein Chain: A: PDB Molecule:cortactin isoform a; PDBTitle: solution structures of the sh3 domain of human src2 substrate cortactin 72 c2eyxA_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: c-terminal sh3 domain of ct10-regulated kinase 73 c2azsA_ not modelled 99.8 46 PDB header:signaling protein Chain: A: PDB Molecule:sh2-sh3 adapter protein drk; PDBTitle: nmr structure of the n-terminal sh3 domain of drk2 (calculated without noe restraints) 74 d1nega_ not modelled 99.8 28 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 75 c1negA_ not modelled 99.8 28 PDB header:structural protein Chain: A: PDB Molecule:spectrin alpha chain, brain; PDBTitle: crystal structure analysis of n-and c-terminal labeled sh3-2 domain of alpha-chicken spectrin 76 d1ujya_ not modelled 99.8 27 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 77 c2dl8A_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:slit-robo rho gtpase-activating protein 2; PDBTitle: solution structure of the sh3 domain of human slit-robo rho2 gtpase-activating protein 2 78 c2ekhA_ not modelled 99.8 20 PDB header:signaling protein Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a; PDBTitle: solution structures of the sh3 domain of human kiaa0418 79 c1x2pA_ not modelled 99.7 25 PDB header:transferase Chain: A: PDB Molecule:protein arginine n-methyltransferase 2; PDBTitle: solution structure of the sh3 domain of the protein2 arginine n-methyltransferase 2 80 c2dbmA_ not modelled 99.7 35 PDB header:transferase, signaling protein Chain: A: PDB Molecule:sh3-containing grb2-like protein 2; PDBTitle: solution structures of the sh3 domain of human sh3-2 containing grb2-like protein 2 81 c2egeA_ not modelled 99.7 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein kiaa1666; PDBTitle: solution structure of the third sh3 domain from human2 kiaa1666 protein 82 c1w70A_ not modelled 99.7 32 PDB header:sh3 domain Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: sh3 domain of p40phox complexed with c-terminal polyproline2 region of p47phox 83 d1e6ha_ not modelled 99.7 24 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 84 c2dbkA_ not modelled 99.7 20 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structures of the sh3 domain of human crk-like2 protein 85 c2egaA_ not modelled 99.7 22 PDB header:signaling protein Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a; PDBTitle: solution structure of the first sh3 domain from human2 kiaa0418 protein 86 d1h8ka_ not modelled 99.7 25 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 87 c1zlmA_ not modelled 99.7 45 PDB header:signaling protein Chain: A: PDB Molecule:osteoclast stimulating factor 1; PDBTitle: crystal structure of the sh3 domain of human osteoclast2 stimulating factor 88 c2e5kA_ not modelled 99.7 21 PDB header:protein binding Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1; PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1 89 c1x43A_ not modelled 99.7 27 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:sh3 domain grb2-like protein b1; PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1) 90 c1x6bA_ not modelled 99.7 22 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine exchange factor (gef) 16; PDBTitle: solution structures of the sh3 domain of human rho guanine2 exchange factor (gef) 16 91 c3rnjA_ not modelled 99.7 20 PDB header:protein binding Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein PDBTitle: crystal structure of the sh3 domain from irsp53 (baiap2) 92 c2krnA_ not modelled 99.7 38 PDB header:signaling protein Chain: A: PDB Molecule:cd2-associated protein; PDBTitle: high resolution structure of the second sh3 domain of cd2ap 93 c2i0nA_ not modelled 99.7 25 PDB header:structural protein Chain: A: PDB Molecule:class vii unconventional myosin; PDBTitle: structure of dictyostelium discoideum myosin vii sh3 domain2 with adjacent proline rich region 94 c2yupA_ not modelled 99.7 26 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the second sh3 domain of human vinexin 95 c2d1xD_ not modelled 99.7 37 PDB header:cell invasion Chain: D: PDB Molecule:cortactin isoform a; PDBTitle: the crystal structure of the cortactin-sh3 domain and amap1-2 peptide complex 96 c2ed1A_ not modelled 99.7 33 PDB header:signaling protein Chain: A: PDB Molecule:130 kda phosphatidylinositol 4,5-biphosphate- PDBTitle: solution structure of the sh3 domain of 130 kda2 phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase-3 activating protein 97 d1ov3a1 not modelled 99.7 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 98 c1x6gA_ not modelled 99.7 18 PDB header:signaling protein Chain: A: PDB Molecule:megakaryocyte-associated tyrosine-protein kinase; PDBTitle: solution structures of the sh3 domain of human2 megakaryocyte-associated tyrosine-protein kinase. 99 c2eqiA_ not modelled 99.7 30 PDB header:immune system, hydrolase Chain: A: PDB Molecule:phospholipase c, gamma 2; PDBTitle: solution structure of the sh3 domain from phospholipase c,2 gamma 2 100 d1uhfa_ not modelled 99.7 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 101 c2cucA_ not modelled 99.7 30 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain containing ring finger 2; PDBTitle: solution structure of the sh3 domain of the mouse2 hypothetical protein sh3rf2 102 c2o2oA_ not modelled 99.7 27 PDB header:protein binding Chain: A: PDB Molecule:sh3-domain kinase-binding protein 1; PDBTitle: solution structure of domain b from human cin85 protein 103 c2rf0D_ not modelled 99.7 45 PDB header:transferase Chain: D: PDB Molecule:mitogen-activated protein kinase kinase kinase 10; PDBTitle: crystal structure of human mixed lineage kinase map3k10 sh3 domain 104 c1wyxA_ not modelled 99.7 36 PDB header:cell adhesion Chain: A: PDB Molecule:crk-associated substrate; PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution 105 d1uj0a_ not modelled 99.7 56 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 106 d1wfwa_ not modelled 99.7 22 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 107 c1g83A_ not modelled 99.7 37 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 108 c2kbtA_ not modelled 99.7 32 PDB header:signaling protein Chain: A: PDB Molecule:chimera of proto-oncogene vav, linker, PDBTitle: attachment of an nmr-invisible solubility enhancement tag2 (inset) using a sortase-mediated protein ligation method 109 c2dl7A_ not modelled 99.7 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa0769 protein; PDBTitle: solution structure of the second sh3 domain of human2 kiaa0769 protein 110 c1zukA_ not modelled 99.7 21 PDB header:contractile protein Chain: A: PDB Molecule:myosin tail region-interacting protein mti1; PDBTitle: yeast bbc1 sh3 domain complexed with a peptide from las17 111 c1bb9A_ not modelled 99.7 28 PDB header:transferase Chain: A: PDB Molecule:amphiphysin 2; PDBTitle: crystal structure of the sh3 domain from rat amphiphysin 2 112 d1bb9a_ not modelled 99.7 28 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 113 c3qwxX_ not modelled 99.7 25 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 114 c3cqtA_ not modelled 99.7 44 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: n53i v55l mutant of fyn sh3 domain 115 c3qwyA_ not modelled 99.7 26 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 116 d1ug1a_ not modelled 99.7 18 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 117 c2j6kE_ not modelled 99.7 27 PDB header:protein binding Chain: E: PDB Molecule:cd2-associated protein; PDBTitle: n-terminal sh3 domain of cms (cd2ap human homolog) 118 c2jteA_ not modelled 99.7 31 PDB header:signaling protein Chain: A: PDB Molecule:cd2-associated protein; PDBTitle: third sh3 domain of cd2ap 119 d1uhca_ not modelled 99.7 24 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 120 c2ke9A_ not modelled 99.7 29 PDB header:protein binding Chain: A: PDB Molecule:caskin-2; PDBTitle: nmr solution structure of the caskin sh3 domain