BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (423 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...   847   0.0  
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...   486   e-136
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...   442   e-122
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...   374   e-102
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...   283   7e-75
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...   268   3e-70
UniRef50_Q4S861 Chromosome 5 SCAF14709, whole genome shotgun seq...   264   4e-69
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...   239   1e-61
UniRef50_UPI00006A214E SH2 domain-containing adapter protein E. ...   209   2e-52
UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=...   189   2e-46
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   179   2e-43
UniRef50_UPI00016E0CC8 UPI00016E0CC8 related cluster n=1 Tax=Tak...   171   4e-41
UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=...   157   6e-37
UniRef50_Q6PD21-2 Isoform 2 of SH2 domain-containing adapter pro...   155   4e-36
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...   149   2e-34
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...   148   3e-34
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...   148   4e-34
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...   145   4e-33
UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=...   144   5e-33
UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 doma...   143   1e-32
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...   136   1e-30
UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS         135   3e-30
UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU...   135   3e-30
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...   135   3e-30
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...   131   5e-29
UniRef50_A4II17 Shd protein (Fragment) n=3 Tax=Xenopus (Silurana...   111   6e-23
UniRef50_Q0P4A0 Shd protein n=5 Tax=Clupeocephala RepID=Q0P4A0_D...   109   2e-22
UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA ...   108   3e-22
UniRef50_Q4RIA8 Chromosome 8 SCAF15044, whole genome shotgun seq...   106   1e-21
UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 doma...   106   1e-21
UniRef50_Q5BWZ4 SJCHGC04657 protein (Fragment) n=1 Tax=Schistoso...    99   3e-19
UniRef50_UPI0000D9E9A9 PREDICTED: similar to src homology 2 doma...    99   3e-19
UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni Re...    99   3e-19
UniRef50_C3ZPI6 Putative uncharacterized protein n=2 Tax=Branchi...    92   3e-17
UniRef50_B7PK27 Putative uncharacterized protein n=1 Tax=Ixodes ...    87   2e-15
UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni Re...    86   4e-15
UniRef50_UPI0000D9F428 PREDICTED: similar to Src homology 2 doma...    77   8e-13
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...    74   1e-11
UniRef50_UPI0001925BB9 PREDICTED: similar to Shb=Src homology 2 ...    69   2e-10
UniRef50_UPI0000E49F60 PREDICTED: hypothetical protein n=2 Tax=S...    67   1e-09
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...    65   6e-09
UniRef50_A1L1W5 Zgc:158464 n=2 Tax=Danio rerio RepID=A1L1W5_DANRE      65   7e-09
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...    64   9e-09
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...    62   4e-08
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...    62   5e-08
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS           61   6e-08
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...    61   6e-08
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...    61   7e-08
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...    61   7e-08
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...    61   8e-08
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO           60   1e-07
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...    60   2e-07
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...    59   3e-07
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...    59   4e-07
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...    59   5e-07
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...    59   5e-07
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...    59   5e-07
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...    58   7e-07
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...    58   9e-07
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...    57   1e-06
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...    57   1e-06
UniRef50_A6NKC9 SH2 domain-containing protein 7 n=4 Tax=Euteleos...    57   1e-06
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    57   2e-06
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...    56   2e-06
UniRef50_UPI0000E48AB6 PREDICTED: similar to B-cell linker n=1 T...    56   2e-06
UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=...    56   3e-06
UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis R...    56   3e-06
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...    56   3e-06
UniRef50_UPI000180B9A8 PREDICTED: similar to Protein vav-2 n=1 T...    55   4e-06
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...    55   5e-06
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...    54   8e-06
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...    54   1e-05
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...    54   1e-05
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...    54   1e-05
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...    54   1e-05
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...    54   1e-05
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...    54   1e-05
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE         54   1e-05
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...    53   2e-05
UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containi...    53   2e-05
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...    53   2e-05
UniRef50_UPI0001555700 PREDICTED: similar to hCG34612 n=1 Tax=Or...    52   3e-05
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    52   4e-05
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...    52   4e-05
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...    52   4e-05
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...    52   5e-05
UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Eutele...    52   5e-05
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA     52   5e-05
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...    52   6e-05
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...    51   6e-05
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...    51   7e-05
UniRef50_UPI00019255F9 PREDICTED: similar to V-crk sarcoma virus...    51   7e-05
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...    51   7e-05
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...    51   7e-05
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...    51   7e-05
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...    51   7e-05
UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus...    51   9e-05
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...    51   9e-05
UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=...    50   1e-04
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...    50   1e-04
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...    50   1e-04
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    50   1e-04
UniRef50_C3XTW6 Putative uncharacterized protein n=4 Tax=Branchi...    50   1e-04
UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=...    50   1e-04
UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixo...    50   1e-04
UniRef50_Q8BI17 SH2 domain-containing protein 7 n=7 Tax=Euarchon...    50   1e-04
UniRef50_UPI0000E460CB PREDICTED: similar to V-crk sarcoma virus...    50   2e-04
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...    50   2e-04
UniRef50_Q22070 Protein T01E8.3, partially confirmed by transcri...    50   2e-04
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...    50   2e-04
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...    50   2e-04
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    50   2e-04
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...    50   2e-04
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...    50   2e-04
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...    50   2e-04
UniRef50_B8JL24 Novel protein similar to human and mouse SH2 dom...    50   2e-04
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...    50   2e-04
UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3...    50   2e-04
UniRef50_UPI00017F08F6 PREDICTED: similar to SH2D2A protein n=1 ...    49   2e-04
UniRef50_UPI0001758844 PREDICTED: similar to vav1 n=1 Tax=Tribol...    49   2e-04
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...    49   3e-04
UniRef50_Q7YWN4 Protein Y87G2A.17, partially confirmed by transc...    49   3e-04
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...    49   3e-04
UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia mal...    49   3e-04
UniRef50_A9Q0R3 Suppressor of cytokine signaling 1 variant 2 n=1...    49   3e-04
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...    49   3e-04
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...    49   4e-04
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    49   4e-04
UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi Rep...    49   4e-04
UniRef50_Q9NP31 SH2 domain-containing protein 2A n=22 Tax=Theria...    49   4e-04
UniRef50_UPI000186E9A4 SH2 domain-containing protein 4A, putativ...    49   5e-04
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...    49   5e-04
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...    49   5e-04
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...    49   5e-04
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...    49   5e-04
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...    49   5e-04
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...    48   5e-04
UniRef50_C3YM24 Putative uncharacterized protein n=2 Tax=Branchi...    48   6e-04
UniRef50_A9V1A4 Predicted protein (Fragment) n=1 Tax=Monosiga br...    48   6e-04
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...    48   6e-04
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...    48   6e-04
UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniot...    48   7e-04
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...    48   7e-04
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...    48   7e-04
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...    48   7e-04
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...    48   7e-04
UniRef50_B6IKC5 Putative uncharacterized protein n=1 Tax=Caenorh...    48   7e-04
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...    48   7e-04
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI          48   7e-04
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE      47   0.001
UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichop...    47   0.001
UniRef50_Q7JVF1 Suppressor of cytokine signaling at 44A n=12 Tax...    47   0.001
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...    47   0.001
UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome ...    47   0.001
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...    47   0.001
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...    47   0.001
UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, part...    47   0.001
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...    47   0.002
UniRef50_A8P112 Variant SH3 domain containing protein n=1 Tax=Br...    47   0.002
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS          47   0.002
UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 ...    47   0.002
UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio Rep...    47   0.002
UniRef50_D2HL11 Putative uncharacterized protein (Fragment) n=4 ...    47   0.002
UniRef50_UPI00017B2438 UPI00017B2438 related cluster n=1 Tax=Tet...    47   0.002
UniRef50_UPI0000D56C32 PREDICTED: similar to suppressor of cytok...    47   0.002
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...    46   0.002
UniRef50_A9V255 Predicted protein n=1 Tax=Monosiga brevicollis R...    46   0.002
UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q...    46   0.002
UniRef50_A9URA8 Predicted protein n=3 Tax=Monosiga brevicollis R...    46   0.002
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...    46   0.002
UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepI...    46   0.002
UniRef50_Q1LWW1 Novel protein similar to vertebrate phospholipas...    46   0.002
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...    46   0.002
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...    46   0.002
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...    46   0.002
UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2...    46   0.003
UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE       46   0.003
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...    46   0.003
UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=S...    46   0.003
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...    46   0.003
UniRef50_A9UZF3 Predicted protein n=1 Tax=Monosiga brevicollis R...    46   0.003
UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Eute...    46   0.003
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...    46   0.003
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...    46   0.003
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...    46   0.003
UniRef50_A9V8Y4 Predicted protein n=1 Tax=Monosiga brevicollis R...    45   0.004
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...    45   0.004
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...    45   0.004
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...    45   0.004
UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Tak...    45   0.004
UniRef50_Q4SKC0 Chromosome 13 SCAF14566, whole genome shotgun se...    45   0.004
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...    45   0.004
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    45   0.004
UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis R...    45   0.004
UniRef50_Q56A36 Hematopoietic SH2 domain-containing protein homo...    45   0.004
UniRef50_C3XWJ1 Putative uncharacterized protein n=1 Tax=Branchi...    45   0.005
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...    45   0.005
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...    45   0.005
UniRef50_D1G5I2 Cytokine signaling 2 n=1 Tax=Eriocheir sinensis ...    45   0.006
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...    45   0.006
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...    45   0.006
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...    45   0.006
UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Euther...    45   0.006
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...    45   0.006
UniRef50_B1H1T7 LOC100158303 protein n=3 Tax=Xenopus RepID=B1H1T...    45   0.006
UniRef50_D2H965 Putative uncharacterized protein (Fragment) n=3 ...    45   0.007
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...    45   0.007
UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE     45   0.007
UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 ...    45   0.007
UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=...    45   0.007
UniRef50_Q96JZ2 Hematopoietic SH2 domain-containing protein n=17...    44   0.008
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...    44   0.008
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...    44   0.008
UniRef50_B2MW85 Phosphatidylinositol 3-kinase 60 n=1 Tax=Bombyx ...    44   0.008
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...    44   0.008
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...    44   0.008
UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorh...    44   0.008
UniRef50_UPI000052380F PREDICTED: similar to phosphoinositide-3-...    44   0.009
UniRef50_UPI0000F2151D PREDICTED: similar to SH2B adapter protei...    44   0.009
UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=...    44   0.009
UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis...    44   0.009
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...    44   0.009
UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tet...    44   0.009
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...    44   0.009
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...    44   0.010
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME        44   0.010
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...    44   0.010
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    44   0.010
UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun se...    44   0.011
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN          44   0.011
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...    44   0.012
UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xen...    44   0.012
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...    44   0.012
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.012
UniRef50_A9V0V2 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.013
UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo sal...    44   0.013
UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax...    44   0.014
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...    44   0.014
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.016
UniRef50_A9VBC5 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.017
UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Br...    44   0.017
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...    43   0.017
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...    43   0.018
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...    43   0.019
UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tet...    43   0.019
UniRef50_Q6GP30 MGC80721 protein n=2 Tax=Xenopus RepID=Q6GP30_XENLA    43   0.019
UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome ...    43   0.019
UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS          43   0.019
UniRef50_B5X244 SH2 domain-containing protein 2A n=2 Tax=Salmo s...    43   0.020
UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichop...    43   0.021

>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score =  847 bits (2188), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 419/423 (99%), Positives = 421/423 (99%)

Query: 1   MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 60
           MQQEGGPVRSAPCRTGTLEGSRQGSPGH+KRASPKGSLSSAQPHSWMLTPSPLNSHCAHR
Sbjct: 58  MQQEGGPVRSAPCRTGTLEGSRQGSPGHKKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 117

Query: 61  EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 120
           EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG
Sbjct: 118 EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 177

Query: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGE 180
           SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT EGE
Sbjct: 178 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGE 237

Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
           GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS
Sbjct: 238 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 297

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL
Sbjct: 298 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 357

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
           SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS
Sbjct: 358 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 417

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           LKSSQGFMHMKLSRTK +KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI
Sbjct: 418 LKSSQGFMHMKLSRTKNNKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 477

Query: 421 RTL 423
           RTL
Sbjct: 478 RTL 480


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score =  486 bits (1251), Expect = e-136,   Method: Compositional matrix adjust.
 Identities = 262/322 (81%), Positives = 266/322 (82%), Gaps = 48/322 (14%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPL 161
           LAILEDYADPFDVQETGEGS G SGAP KVPENDGYMEPYEAQKMMAEIRGSKETA QPL
Sbjct: 173 LAILEDYADPFDVQETGEGSGGTSGAPGKVPENDGYMEPYEAQKMMAEIRGSKETAAQPL 232

Query: 162 PLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
           PLYDTPYEPE++GA+ EGEG PWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA    
Sbjct: 233 PLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA---- 288

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
                                                      AQFEG E +CLSPGREE
Sbjct: 289 -------------------------------------------AQFEGSE-NCLSPGREE 304

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 341
           KGRLPPRLSAGNPKSAKPL MEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK
Sbjct: 305 KGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 364

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS
Sbjct: 365 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 424

Query: 402 RKLPIKGAEHMSLLYPVAIRTL 423
           RKLPIKGAEHMSLLYPVAIRTL
Sbjct: 425 RKLPIKGAEHMSLLYPVAIRTL 446


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score =  442 bits (1137), Expect = e-122,   Method: Compositional matrix adjust.
 Identities = 229/286 (80%), Positives = 233/286 (81%), Gaps = 48/286 (16%)

Query: 138 MEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERP 197
           MEPYEAQKMMAEIRGSKETA QPLPLYDTPYEPE++GA+ EGEG PWPRESRLPEDDERP
Sbjct: 1   MEPYEAQKMMAEIRGSKETAAQPLPLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERP 60

Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
           PEEYDQPWEWKKERISKAFA                                        
Sbjct: 61  PEEYDQPWEWKKERISKAFA---------------------------------------- 80

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
                  AQFEG E +CLSPGREEKGRLPPRLSAGNPKSAKPL MEPSSPLGEWTDPALP
Sbjct: 81  -------AQFEGSE-NCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALP 132

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE
Sbjct: 133 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 192

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
Sbjct: 193 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 238


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score =  374 bits (959), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 201/326 (61%), Positives = 229/326 (70%), Gaps = 55/326 (16%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR--GSKETATQ 159
           +AI+EDYADPFD ++      G+  APEKV ENDGYMEPYEAQKMMAEIR  GSKE    
Sbjct: 184 VAIVEDYADPFDAKQV----PGSQNAPEKVTENDGYMEPYEAQKMMAEIRRRGSKELPCT 239

Query: 160 PLPLYDTPYEPEEDGATAEGEGAP--WPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
           PL LYDTPYEP E+G  +EGE +    PRESRLP+DDERPPEEYDQPWEWKKERISKAFA
Sbjct: 240 PLHLYDTPYEPSENGLDSEGEKSTSQRPRESRLPQDDERPPEEYDQPWEWKKERISKAFA 299

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSP 277
                                                          AQF+  +K+ ++ 
Sbjct: 300 -----------------------------------------------AQFDSADKTGMAA 312

Query: 278 GREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL 337
            +E+K R   R SAGN K+ K  S+E    +GE  DP+LPLE+Q WYHGAISR DAE+LL
Sbjct: 313 AKEDKPRHMHRHSAGNLKAIKHPSVEHCISVGERIDPSLPLESQFWYHGAISRADAESLL 372

Query: 338 RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
           RLCKEASYLVRNSET+K DFSLSLKS QGFMHMKLSRTKE+KYVLG NSPPF+SVPEI+H
Sbjct: 373 RLCKEASYLVRNSETNKIDFSLSLKSIQGFMHMKLSRTKENKYVLGHNSPPFNSVPEIIH 432

Query: 398 HYASRKLPIKGAEHMSLLYPVAIRTL 423
           HYAS+KLPIKGAEHMSLLYPVA+RTL
Sbjct: 433 HYASQKLPIKGAEHMSLLYPVAVRTL 458


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score =  283 bits (725), Expect = 7e-75,   Method: Compositional matrix adjust.
 Identities = 161/326 (49%), Positives = 198/326 (60%), Gaps = 60/326 (18%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQ-- 159
           + I +DY+DPFD +   +  AG         E+ GYMEPYEAQ++M E +  +   +Q  
Sbjct: 240 VTIADDYSDPFDAKNDLKSKAGKG-------ESAGYMEPYEAQRIMTEFQRQESVRSQHK 292

Query: 160 PLPLYDTPYEPEEDGATAEGEG--APWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
            + LYDTPYEPE     ++ E   +P  RES+LP+DD+RP +EYDQPWEW +  I     
Sbjct: 293 GIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTI----- 347

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSP 277
                                                   P+L   +AQF G EK   SP
Sbjct: 348 ----------------------------------------PAL---AAQFNGNEKRQSSP 364

Query: 278 GREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL 337
                 R   R   G  K  K  S E    LGE  DPA+PLE Q+WYHGAISR DAENLL
Sbjct: 365 SPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLL 424

Query: 338 RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
           RLCKE SYLVRNS+TSK+D+SLSL+S+QGFMHMKL++TKE KYVLGQNSPPF SVPE++H
Sbjct: 425 RLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSVPEVIH 483

Query: 398 HYASRKLPIKGAEHMSLLYPVAIRTL 423
           +Y +RKLPIKGAEH+SLLYPVA+RTL
Sbjct: 484 YYTTRKLPIKGAEHLSLLYPVAVRTL 509


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score =  268 bits (685), Expect = 3e-70,   Method: Compositional matrix adjust.
 Identities = 154/329 (46%), Positives = 195/329 (59%), Gaps = 74/329 (22%)

Query: 107 DYADPFDVQ-----ETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQP- 160
           DY+DPFDV+     E+ +G           PEN+GYMEPYEAQK++ E++          
Sbjct: 125 DYSDPFDVRLDPRPESAQGQI--------TPENNGYMEPYEAQKVITELQRRAGGGAGGW 176

Query: 161 ----LPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAF 216
               + LYD PYE    G     E     RESRLP+DD+RP +EYDQPWEWKKE ISKAF
Sbjct: 177 GRGEVQLYDAPYEERVPGQPDLPEEG---RESRLPQDDDRPADEYDQPWEWKKEHISKAF 233

Query: 217 AVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPE--KSC 274
           AV                                               QFEG E  +SC
Sbjct: 234 AV-----------------------------------------------QFEGAEWDRSC 246

Query: 275 LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAE 334
               R    R PP  + G+ K  KP   +P S +GE  DP+LPLE QVWYHG++SR++AE
Sbjct: 247 SPTERLRCSRAPP--TTGSMKLRKP--SDPHSMIGERVDPSLPLEKQVWYHGSLSRSEAE 302

Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
           +LL LCKE SYLVRNSETS+ D+SLSL+S QGFMHMK S+ K+ +Y+LGQNSPPF ++PE
Sbjct: 303 SLLTLCKECSYLVRNSETSRLDYSLSLRSCQGFMHMKFSQCKDGRYILGQNSPPFETIPE 362

Query: 395 IVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           ++H+Y + KLPIKGAEH+SLL+PV ++TL
Sbjct: 363 VIHYYTTHKLPIKGAEHLSLLFPVLVQTL 391


>UniRef50_Q4S861 Chromosome 5 SCAF14709, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4S861_TETNG
          Length = 775

 Score =  264 bits (675), Expect = 4e-69,   Method: Compositional matrix adjust.
 Identities = 153/307 (49%), Positives = 191/307 (62%), Gaps = 53/307 (17%)

Query: 151 RGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKE 210
           RG KE + + LPLYDTPYEP E+G  ++ E +  PRESRLP+DDERPPEEYDQPWEWKKE
Sbjct: 488 RGPKEGSVRQLPLYDTPYEPAENGGDSDPERSRCPRESRLPQDDERPPEEYDQPWEWKKE 547

Query: 211 RISKAFA---------------------------------VDIKVIKDLPWPPPVGQLDS 237
           RISKAFA                                 V+IKVIK+LPWPPPVGQL+S
Sbjct: 548 RISKAFAALLCYDCISYEGSVSDTGSGSHGGKDCTSNSLTVEIKVIKNLPWPPPVGQLNS 607

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA 297
           +P++ +   ++  P      P     + QF+G EKS +SP ++ K R   R S+G   + 
Sbjct: 608 TPTVVE---ELESPTQTAQAP--PGQTFQFDGVEKSRMSPTKDGKTRPLQRHSSGCLVNT 662

Query: 298 KPLSMEPSSP-LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
           K  S+E   P L E  DP++PLE+Q+             L +LC     ++R +   +  
Sbjct: 663 KMSSLEHCGPSLAERIDPSMPLESQL-------------LCQLCSNCRVVIR-AAVKRRV 708

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           F   L+SSQGFMHMKLSRTKE+KY+LGQNS PF SVPEI+H Y+S KLPIKGAEHMSLLY
Sbjct: 709 FPCVLRSSQGFMHMKLSRTKENKYILGQNSCPFDSVPEIIHFYSSCKLPIKGAEHMSLLY 768

Query: 417 PVAIRTL 423
           PVAIRTL
Sbjct: 769 PVAIRTL 775



 Score = 63.5 bits (153), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 32/48 (66%), Positives = 37/48 (77%), Gaps = 4/48 (8%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVP-ENDGYMEPYEAQKMMA 148
           L ILEDYADPFD ++ G G+  ++   EKV  ENDGYMEPYEAQKMMA
Sbjct: 296 LIILEDYADPFDAEQAGGGTQTST---EKVTTENDGYMEPYEAQKMMA 340


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score =  239 bits (611), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 148/352 (42%), Positives = 190/352 (53%), Gaps = 94/352 (26%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR---------- 151
           + ILEDYADP+D + T +G   A    E+V ENDGYMEPY+AQ+M+ EIR          
Sbjct: 198 VIILEDYADPYDAKRT-KGQRDA----ERVGENDGYMEPYDAQQMITEIRRRGSKDPLVK 252

Query: 152 -------------------------GSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPR 186
                                     SK+   +P  LYDTPYEP E G  AEG+  P   
Sbjct: 253 ALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKARP--P 310

Query: 187 ESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDR 246
           +SRLPE+DERP  EY+QPWEWKKE+I +A +V                            
Sbjct: 311 DSRLPENDERPAAEYEQPWEWKKEQIVRALSV---------------------------- 342

Query: 247 DISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSS 306
                              QFEG E+      REE  R   R  +   K  KP   + S 
Sbjct: 343 -------------------QFEGAERPSF---REETVRQHHRQKSWTQKILKPALSDHSE 380

Query: 307 PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
             GE  DP LPLE Q WYHGAISR +AE+ L+ CKEA YLVRNSE+  + +S++LK+SQG
Sbjct: 381 --GEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQG 438

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            +H+ +++TK++KY L Q S  F S+PE+VH+Y++ KLP KGAEHM+LLYPV
Sbjct: 439 CVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490


>UniRef50_UPI00006A214E SH2 domain-containing adapter protein E. n=1 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A214E
          Length = 437

 Score =  209 bits (531), Expect = 2e-52,   Method: Compositional matrix adjust.
 Identities = 129/348 (37%), Positives = 180/348 (51%), Gaps = 90/348 (25%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR---------- 151
           + I+E+YA P+D + T +         E++ ENDGYMEPY+AQ+M+ EIR          
Sbjct: 144 IIIIENYAIPYDAKCTKDPRDA-----ERLGENDGYMEPYDAQQMITEIRRRGSKDNLIT 198

Query: 152 --------------------GSKETATQPLPLYDTPYEPEEDGATAE-GEGAPWPRESRL 190
                               GS+E   +   LYDTPYEP + G  AE  E      +   
Sbjct: 199 ELLLLELGPPCGLKTVVRRPGSQELLDRAPQLYDTPYEPPDAGGEAEPQENKGSAGDGTR 258

Query: 191 PEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISG 250
           PE+DERP  EY+QPWEWKKE I +A +V                                
Sbjct: 259 PENDERPAGEYEQPWEWKKEHIVRALSV-------------------------------- 286

Query: 251 PASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE 310
                          QFE  E+S   P +EE GR   R  +  PK  K    E     G+
Sbjct: 287 ---------------QFENSERS---PSKEEPGRSHQRQKSWTPKVLKQHQAEQ----GD 324

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
             DP +PLE Q WYHG+++R  AE+LL  C EASYL+RNS +  + +S++LK+SQG +H+
Sbjct: 325 KVDPTVPLEKQSWYHGSVTRDQAESLLDSCPEASYLLRNSGSGNSKYSIALKTSQGCVHI 384

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            +++TK +K+ L Q    F+S+PE+VHHY+S+KLP KG++H+SLL+PV
Sbjct: 385 IVAQTKNNKFTLSQMCGAFNSIPEVVHHYSSQKLPFKGSKHISLLHPV 432


>UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=5 Tax=Eutheria
           RepID=B0R097_MOUSE
          Length = 161

 Score =  189 bits (479), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 90/90 (100%), Positives = 90/90 (100%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL
Sbjct: 72  WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 131

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           GQNSPPFSSVPEIVHHYASRKLPIKGAEHM
Sbjct: 132 GQNSPPFSSVPEIVHHYASRKLPIKGAEHM 161



 Score = 92.0 bits (227), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 42/49 (85%), Positives = 45/49 (91%)

Query: 173 DGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
           +GA+ EGEG PWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA D +
Sbjct: 1   EGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAGDTQ 49


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  179 bits (453), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 76/121 (62%), Positives = 102/121 (84%)

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
           +P   LGE  DP LPLE QVWYHGA++R++AE+LL LCKE SYLVR S+TS+ND+SLSL+
Sbjct: 201 KPHGILGERVDPMLPLEKQVWYHGALTRSEAESLLTLCKECSYLVRKSQTSRNDYSLSLR 260

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           S  GFMHMK S++++ K++LG+NSPPF S+PE++H Y + KLPI+GAEH+SLL+PV ++T
Sbjct: 261 SCHGFMHMKFSQSRDGKFILGENSPPFDSIPEVIHFYTTNKLPIRGAEHLSLLFPVLVQT 320

Query: 423 L 423
           L
Sbjct: 321 L 321


>UniRef50_UPI00016E0CC8 UPI00016E0CC8 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E0CC8
          Length = 215

 Score =  171 bits (434), Expect = 4e-41,   Method: Compositional matrix adjust.
 Identities = 99/175 (56%), Positives = 122/175 (69%), Gaps = 3/175 (1%)

Query: 151 RGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKE 210
           RG KE + + LPLYDTPYEP E+G  ++ E    PRESRLP+DDERPPEEYDQPWEWKKE
Sbjct: 14  RGPKEGSVRQLPLYDTPYEPAENGGDSDPEHPRVPRESRLPQDDERPPEEYDQPWEWKKE 73

Query: 211 RISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP--EPSLEDSSAQFE 268
           RISKAFAV+IKVIKDLPWPPPVGQL+S+P + +     S  A PL    P    SS QF+
Sbjct: 74  RISKAFAVEIKVIKDLPWPPPVGQLNSTPPVVEELESPSQTAQPLQVNHPFFTSSSVQFD 133

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP-LGEWTDPALPLENQV 322
           G +KS +SP ++ K R   R S G   + K  S++  SP L E  DP++PLE+Q+
Sbjct: 134 GVDKSRMSPTKDGKARPLQRHSGGCLVNTKMSSLDHCSPSLAERIDPSMPLESQL 188


>UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=Euteleostomi
           RepID=SHD_HUMAN
          Length = 340

 Score =  157 bits (398), Expect = 6e-37,   Method: Compositional matrix adjust.
 Identities = 73/114 (64%), Positives = 93/114 (81%)

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
            E  DPALPLE Q W+HG ++R DAE+LL LCKE SYLVR SET+  D SLSL+SSQGF+
Sbjct: 226 AERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFL 285

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           H+K +RT+E++ VLGQ+S PF SVPE+V HY+SR LP++GAEH++LLYPV  +T
Sbjct: 286 HLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQT 339


>UniRef50_Q6PD21-2 Isoform 2 of SH2 domain-containing adapter protein B n=4
           Tax=Amniota RepID=Q6PD21-2
          Length = 217

 Score =  155 bits (391), Expect = 4e-36,   Method: Compositional matrix adjust.
 Identities = 98/228 (42%), Positives = 119/228 (52%), Gaps = 52/228 (22%)

Query: 138 MEPYEAQKMMAEIRGSKETATQP--LPLYDTPYEPEEDGATAEGEGAP--WPRESRLPED 193
           MEPYEAQ++M E +  +   +Q   + LYDTPYEPE     ++ E       RES+LP+D
Sbjct: 1   MEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSLRLRESKLPQD 60

Query: 194 DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
           D+RP +EYDQPWEW +  I                                         
Sbjct: 61  DDRPADEYDQPWEWNRVTI----------------------------------------- 79

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
               P+L   +AQF G EK   SP      R   R   G  K  K  S E    LGE  D
Sbjct: 80  ----PAL---AAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVD 132

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSL 361
           P +PLE Q+WYHGAISR+DAENLLRLCKE SYLVRNS+TSK+D+SLSL
Sbjct: 133 PTIPLEKQIWYHGAISRSDAENLLRLCKECSYLVRNSQTSKHDYSLSL 180


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score =  149 bits (375), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 66/115 (57%), Positives = 90/115 (78%), Gaps = 1/115 (0%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  DP+LPLE Q WYHG+I+R +AE+LLR  KE SYLVRNSE++K D+SLSLKS++GFMH
Sbjct: 1081 DLIDPSLPLEKQTWYHGSITRVEAEDLLRSLKEGSYLVRNSESAKQDYSLSLKSAKGFMH 1140

Query: 370  MKLS-RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++       +++LGQ S PF+S+P+++ HY+  KLPI+GAEHM LL PVA + L
Sbjct: 1141 MRIQIDNNSGQFILGQFSKPFNSIPDMIRHYSVNKLPIRGAEHMCLLKPVAAQLL 1195


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score =  148 bits (374), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 67/126 (53%), Positives = 94/126 (74%), Gaps = 1/126 (0%)

Query: 299  PLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
            PL +  +    +  D  LPLE Q WYHG+I+R +AE +LRL +E SYLVRNSE++K D+S
Sbjct: 997  PLEINTARGSADLVDVGLPLERQGWYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYS 1056

Query: 359  LSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
            LSLKS++GFMHM++ + +E + Y+LGQ S PF S+PE+V H++  +LPI+GAEHM LL+P
Sbjct: 1057 LSLKSARGFMHMRIQKNEELNAYILGQFSKPFDSIPEMVRHFSVNRLPIRGAEHMCLLHP 1116

Query: 418  VAIRTL 423
            V  + L
Sbjct: 1117 VIAQLL 1122


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score =  148 bits (373), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 69/127 (54%), Positives = 97/127 (76%), Gaps = 3/127 (2%)

Query: 300  LSMEPSSPLG--EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDF 357
            LS+E ++  G  +  D  LPLE Q WYHG+I+R +AE +LRL +E SYLVRNSE++K D+
Sbjct: 1056 LSLELTASRGSADLVDVELPLERQGWYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDY 1115

Query: 358  SLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
            SLSLKS++GFMHM++ + +E + Y+LGQ S PF S+PE+V H++  +LPI+GAEHM LL+
Sbjct: 1116 SLSLKSARGFMHMRIQKNEELNAYILGQFSKPFDSIPEMVRHFSINRLPIRGAEHMCLLH 1175

Query: 417  PVAIRTL 423
            PV  + L
Sbjct: 1176 PVIAQLL 1182


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score =  145 bits (365), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 63/118 (53%), Positives = 88/118 (74%), Gaps = 1/118 (0%)

Query: 307 PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
           P  +  D  LPLE Q W+HGAI+R +AEN+LR+ +E S+LVRNSE++K D+SLSLKS++G
Sbjct: 781 PTADVIDVNLPLEKQGWFHGAITRVEAENVLRMLREGSFLVRNSESTKQDYSLSLKSARG 840

Query: 367 FMHMKLSRT-KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           FMHM++ +   +  Y+LGQ S PF S+PE++ H+   +LPI+GAEHM LL PV  + L
Sbjct: 841 FMHMRIQKDGNDECYILGQFSKPFHSIPEMIRHFCINRLPIRGAEHMCLLQPVIAQLL 898


>UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=Euteleostomi
           RepID=SHD_MOUSE
          Length = 343

 Score =  144 bits (364), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 67/110 (60%), Positives = 86/110 (78%)

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
            E  D AL LE Q W+HG +SR +AENLL LCKE SYLVR SET   D  LSL+S+QG M
Sbjct: 211 AERVDTALALEKQPWFHGPLSRAEAENLLSLCKEGSYLVRLSETRAQDCILSLRSNQGSM 270

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           H+K +RT+E++ VLGQ+S PF S+PE+V HY++R LP++GAEH++LLYPV
Sbjct: 271 HLKFARTRENQVVLGQHSGPFPSIPELVLHYSARPLPVQGAEHLALLYPV 320



 Score = 81.3 bits (199), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 50/119 (42%), Positives = 67/119 (56%), Gaps = 32/119 (26%)

Query: 107 DYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDT 166
           +Y+DPFD Q            P+    N GYMEPY+A+ +      S E  ++ + LYDT
Sbjct: 99  EYSDPFDAQ------------PQPPAPNSGYMEPYDARSV------SSEQPSRAVQLYDT 140

Query: 167 PYE-----PEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI 220
           PYE     PE+ G++ +         SR P +DERP +EYDQPWEWKK+ IS+AFAV  
Sbjct: 141 PYEEQATKPEDGGSSGQ---------SRRPLEDERPADEYDQPWEWKKDHISRAFAVQF 190


>UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=1 Tax=Macaca mulatta RepID=UPI0000D9EE2E
          Length = 221

 Score =  143 bits (360), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 65/100 (65%), Positives = 84/100 (84%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ++R DAE+LL LCKE SYLVR SETS  D SLSL+SSQGF+H+K +RT+E++ VL
Sbjct: 121 WFHGPLNRADAESLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQVVL 180

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           GQ+S PF SVPE+V HY+SR LP++GAEH++LLYPV  +T
Sbjct: 181 GQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQT 220


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score =  136 bits (343), Expect = 1e-30,   Method: Compositional matrix adjust.
 Identities = 58/114 (50%), Positives = 82/114 (71%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  D  +PLE Q WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK ++GFMH
Sbjct: 1397 DLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMH 1456

Query: 370  MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++ R +  +Y+LGQ S PF +VPE++ H+   +LP++GAEHM L+ PV  + L
Sbjct: 1457 MRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1510


>UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS
          Length = 1495

 Score =  135 bits (340), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 57/114 (50%), Positives = 83/114 (72%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  D ++PLE Q WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK ++GFMH
Sbjct: 1382 DLIDVSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMH 1441

Query: 370  MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++ R +  +Y+LGQ S PF +VP+++ H+   +LP++GAEHM L+ PV  + L
Sbjct: 1442 MRIQRNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1495


>UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU33_DROPE
          Length = 1444

 Score =  135 bits (340), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 57/114 (50%), Positives = 83/114 (72%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  D ++PLE Q WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK ++GFMH
Sbjct: 1331 DLIDVSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMH 1390

Query: 370  MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++ R +  +Y+LGQ S PF +VP+++ H+   +LP++GAEHM L+ PV  + L
Sbjct: 1391 MRIQRNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1444


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score =  135 bits (339), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 67/160 (41%), Positives = 103/160 (64%), Gaps = 12/160 (7%)

Query: 269 GPEKSCLSPGREEKGRLPPR----LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWY 324
           G  K  L+    E G+ PP+    L  G       L++  + P  +  D ++PL+ Q WY
Sbjct: 685 GFFKQSLTLNLNECGQRPPKKFGTLDLG-------LNLGTNRPNVDLIDASIPLDRQGWY 737

Query: 325 HGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH-KYVLG 383
           HG+ISR DAE +LR   E S+LVRNSE+++ D+SL+LKS++GFMHM++ R  +  +++LG
Sbjct: 738 HGSISRIDAEKILRPLSEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDADSGQFILG 797

Query: 384 QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           Q S PF ++P+++ H+   +LP++GAEHM LL PV  + L
Sbjct: 798 QFSRPFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQIL 837


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score =  131 bits (329), Expect = 5e-29,   Method: Compositional matrix adjust.
 Identities = 56/115 (48%), Positives = 84/115 (73%), Gaps = 1/115 (0%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  D ++ L+ Q WYHG+ISR DAE +LR   E S+LVRNSE+++ D+SL+LKS++GFMH
Sbjct: 967  DLIDASISLDRQGWYHGSISRIDAEKILRPLGEGSFLVRNSESTRQDYSLTLKSAKGFMH 1026

Query: 370  MKLSRT-KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++ R     +Y+LGQ S PF ++P+++ H+   +LP++GAEHM LL PV  + L
Sbjct: 1027 MRIQRDPDSSQYILGQFSRPFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQIL 1081


>UniRef50_A4II17 Shd protein (Fragment) n=3 Tax=Xenopus (Silurana) tropicalis
           RepID=A4II17_XENTR
          Length = 379

 Score =  111 bits (277), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 89/304 (29%), Positives = 140/304 (46%), Gaps = 46/304 (15%)

Query: 119 EGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAE 178
           EG     G  E  PE+  YM+PYE+Q         +   T  L LYD PY+ ++   T  
Sbjct: 121 EGKNELFGGEE--PEDIRYMDPYESQSTGLHCIMERAAGT-ALKLYDFPYQ-KQFHKTFH 176

Query: 179 GEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSS 238
           G        S+   +DERP +EYDQPWEWKK+ I++AFAV               Q + S
Sbjct: 177 G--------SQQHLEDERPADEYDQPWEWKKDDINRAFAV---------------QFEGS 213

Query: 239 PSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK 298
                   D    +    E  L+ S+  F   +K+  S     +    P+  A       
Sbjct: 214 --------DWQQSSLTRTERLLQPSAKCFRRLQKN--SLSSSPESSTSPKQCAELTDECM 263

Query: 299 PLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
             S+E  +      +P  PL+ QVWYHG +S+ +AE  L+ CK  S+++R  +    ++ 
Sbjct: 264 AYSLEHGT-----LNP--PLQTQVWYHGKLSKLEAEKYLQNCKPGSFVIRIEQDI--EYF 314

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +S++ S    H+K+   +   ++LG++ P F+ + E+V HY    L ++  E + L  PV
Sbjct: 315 MSVRGSHSTQHLKVKCIENEHFMLGESGPSFTCILELVEHYMKHPLLLQNEEQLFLQCPV 374

Query: 419 AIRT 422
              T
Sbjct: 375 FTVT 378


>UniRef50_Q0P4A0 Shd protein n=5 Tax=Clupeocephala RepID=Q0P4A0_DANRE
          Length = 299

 Score =  109 bits (272), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 86/228 (37%), Positives = 106/228 (46%), Gaps = 74/228 (32%)

Query: 108 YADPFDVQ-----ETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQP-- 160
           Y+DPFDV+     E+ +G           PEN+GYMEPYEAQK++ E++           
Sbjct: 126 YSDPFDVRLDPRPESAQGQI--------TPENNGYMEPYEAQKVITELQRRAGGGAGGWG 177

Query: 161 ---LPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
              + LYDTPYE    G     E     RESRLP+DD+RP +EYDQPWEWKKE ISKAFA
Sbjct: 178 RGEVQLYDTPYEERVPGQPDLPEEG---RESRLPQDDDRPADEYDQPWEWKKEHISKAFA 234

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPE--KSCL 275
           V                                               QFEG E  +SC 
Sbjct: 235 V-----------------------------------------------QFEGAEWDRSCS 247

Query: 276 SPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
              R    R PP  + G+ K  KP   +P S +GE  DP+LPLE QV+
Sbjct: 248 PTERLRCSRAPP--TTGSMKLRKP--SDPHSMIGERVDPSLPLEKQVY 291


>UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017925DF
          Length = 555

 Score =  108 bits (270), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 54/122 (44%), Positives = 83/122 (68%), Gaps = 6/122 (4%)

Query: 300 LSMEPSSPLG--EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDF 357
           LS+    PL   E  D +LPL+ Q WYHG ++R +AE  L   KE +YLVR +   K  +
Sbjct: 432 LSLCNIKPLNFVEDIDVSLPLDQQCWYHGPMNRLEAEKALHGQKEGTYLVRGN---KGSY 488

Query: 358 SLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           +LS+KS++GF+HM++++++E  Y LGQ+  PF ++P+++ HY   KLP KGAEH+ L+ P
Sbjct: 489 ALSIKSAKGFIHMRITQSEERNY-LGQSDRPFETIPDLIKHYTLNKLPAKGAEHVGLIRP 547

Query: 418 VA 419
           +A
Sbjct: 548 LA 549


>UniRef50_Q4RIA8 Chromosome 8 SCAF15044, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RIA8_TETNG
          Length = 253

 Score =  106 bits (265), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 48/99 (48%), Positives = 73/99 (73%), Gaps = 3/99 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK--- 379
           WYHG++SR  AE  L+ C+EAS+LVR+SE+  + +S++LK+SQ  +H+ +++TK  K   
Sbjct: 154 WYHGSVSRQQAEAQLQRCREASFLVRDSESGTSKYSIALKTSQSCVHIIVAQTKGVKGLG 213

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           + L Q+S  F S+PE+VHHY + +LP  GAEHM+L +PV
Sbjct: 214 FTLDQSSCVFPSIPELVHHYCTHRLPFTGAEHMTLQHPV 252



 Score = 97.8 bits (242), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 65/148 (43%), Positives = 79/148 (53%), Gaps = 29/148 (19%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETAT--- 158
           L ILEDYADPFD ++T E         E+   NDGYMEPY+AQ ++   RGSK+      
Sbjct: 1   LIILEDYADPFDAEKTKEQREA-----ERAGVNDGYMEPYDAQVIITGERGSKDLLKVCV 55

Query: 159 --------------QPLPL--YDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYD 202
                          PLPL  YDTPYE E DG   EG   P  R    PE D RPP EY+
Sbjct: 56  LLDRGQREGKREEGHPLPLNIYDTPYEGELDG-DREGVWIPVTR----PESDIRPPGEYE 110

Query: 203 QPWEWKKERISKAFAVDIKVIKDLPWPP 230
            PWEW+KE I +A +V  ++ + L W P
Sbjct: 111 LPWEWRKEDIVRALSVPHRMGRWLKWTP 138


>UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 domain containing adaptor
           protein B n=1 Tax=Ciona intestinalis RepID=UPI000180BDCA
          Length = 627

 Score =  106 bits (265), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 53/125 (42%), Positives = 83/125 (66%), Gaps = 5/125 (4%)

Query: 298 KPLSMEPSSPLGEWT-DPALPLENQVWYHGAISRTDAENLLRLCKEA--SYLVRNSETSK 354
           + L + PS  + +   DP LPL  Q WYHGAI+R +A   +RL +E   SYLVRNSE++ 
Sbjct: 501 RQLELHPSEAIADKDFDPLLPLTKQGWYHGAITRDEAN--MRLSREVPGSYLVRNSESTA 558

Query: 355 NDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
           N++SLSL++    +HM +S T++  ++LG+ S PF SVPE++  Y++ +L I   +++SL
Sbjct: 559 NNYSLSLRTRSTTIHMVISSTRDGFWILGEFSAPFHSVPEMIAFYSTHRLKINDTQNISL 618

Query: 415 LYPVA 419
            YP+ 
Sbjct: 619 KYPIT 623


>UniRef50_Q5BWZ4 SJCHGC04657 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BWZ4_SCHJA
          Length = 153

 Score = 99.4 bits (246), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 48/107 (44%), Positives = 76/107 (71%), Gaps = 1/107 (0%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           LPLE Q W+H +++R++AE L+R   E S+LVR SET  NDFSL++K  + F+HMK++R 
Sbjct: 48  LPLEEQPWFHPSLTRSEAEELIRNEPEGSFLVRPSETCPNDFSLTIK-HKTFLHMKITRN 106

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
              +++LG+ S P+SSV ++++HYA   +P+ GA  ++L +PV  R 
Sbjct: 107 NAGQFILGEYSQPYSSVSQMIYHYARTLVPVLGAYSVTLTHPVFKRV 153


>UniRef50_UPI0000D9E9A9 PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=2 Tax=Mammalia RepID=UPI0000D9E9A9
          Length = 239

 Score = 99.0 bits (245), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 57/115 (49%), Positives = 75/115 (65%), Gaps = 20/115 (17%)

Query: 107 DYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDT 166
           +Y+DPFD Q            P   P +DGYMEPY+AQ++M+E+ G        + LYDT
Sbjct: 105 EYSDPFDAQ------------PHPAPPDDGYMEPYDAQRVMSELPGRG------VQLYDT 146

Query: 167 PYEPEEDGATAEGE-GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI 220
           PYE E+D  TA+G      PR+SR+P++DERP +EYDQPWEWKK+ IS+AFAV  
Sbjct: 147 PYE-EQDPETADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQF 200


>UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4Q6F0_SCHMA
          Length = 1070

 Score = 99.0 bits (245), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 47/107 (43%), Positives = 75/107 (70%), Gaps = 1/107 (0%)

Query: 315  ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
             LPLE Q W+H  ++R++AE L+R   E S+LVR SET  NDFSL++K  + F+HMK++R
Sbjct: 964  TLPLEEQPWFHPLLTRSEAEELIRNEPEGSFLVRPSETCPNDFSLTIK-HKSFLHMKITR 1022

Query: 375  TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
                +++LG+ S P++SV ++++HYA   +P+ GA  ++L +PV  R
Sbjct: 1023 NSTGQFILGEYSQPYASVSQMIYHYARTLVPVLGAYSVTLTHPVCKR 1069


>UniRef50_C3ZPI6 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3ZPI6_BRAFL
          Length = 718

 Score = 92.0 bits (227), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 91/281 (32%), Positives = 135/281 (48%), Gaps = 50/281 (17%)

Query: 104 ILEDYADPFDVQETGEGSAGASGAPEKVP--END--GYMEPYEAQKMMAEIR--GSKETA 157
           +L+DY+DP+D+++    S      P+  P  E+D   Y +PY+AQK++ E+R   SKE A
Sbjct: 271 VLDDYSDPYDIRKAVLESRDYDVPPDCRPPKEDDFNNYSDPYDAQKIIQELRIQQSKE-A 329

Query: 158 TQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
            +  P   TP   + +G++++      P E   PED +    +     E +K + ++   
Sbjct: 330 KEETPRSSTP---DSEGSSSDSALYEDPYEPSAPEDIDADTHQARLARELEKAKETQ--- 383

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEP----SLEDSSAQFEGP--- 270
                         + Q       PD D   + PA    +P    S E  S  F      
Sbjct: 384 --------------LKQQQQQQQQPDED---TRPAEDYDQPWEWSSKERLSQAFAAQLDQ 426

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPLS---------MEPSSPLGEWTDPALPLENQ 321
           ++    P          RL+A    SA PLS          E S P+    DP++PLE Q
Sbjct: 427 QQPSPPPSTHTPPSADKRLAAVPESSASPLSKTRVFRKHSHEGSEPI----DPSIPLEGQ 482

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
            WYHG+ISR DAEN+LR C+E S+LVRNSE+S+ +FSLS+K
Sbjct: 483 RWYHGSISRVDAENVLRSCRECSFLVRNSESSRTNFSLSIK 523


>UniRef50_B7PK27 Putative uncharacterized protein n=1 Tax=Ixodes scapularis
           RepID=B7PK27_IXOSC
          Length = 569

 Score = 86.7 bits (213), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 37/61 (60%), Positives = 49/61 (80%)

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           S++GFMHMK+   ++ K++LGQ S PF S+PE++HHY+  KLPIKGAEHMSLLYPV  + 
Sbjct: 509 SARGFMHMKIVHNEDGKFILGQFSKPFESIPEMIHHYSVNKLPIKGAEHMSLLYPVIDQL 568

Query: 423 L 423
           L
Sbjct: 569 L 569


>UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4QQ21_SCHMA
          Length = 1124

 Score = 85.5 bits (210), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 44/103 (42%), Positives = 67/103 (65%), Gaps = 1/103 (0%)

Query: 318  LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
            LENQ+W+H  +SR+ AE LL+     S+LVR SETSK + SLS+K     +HMK+S+  E
Sbjct: 1016 LENQLWFHRDLSRSHAEKLLKSTPTGSFLVRRSETSKTELSLSIKRESDVLHMKISQDPE 1075

Query: 378  H-KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
               YVLG+ S P+ SV  +++ Y+   LP++G   + L +P++
Sbjct: 1076 TGGYVLGEYSQPYPSVSSMIYRYSRTLLPVRGTTPVLLRFPIS 1118


>UniRef50_UPI0000D9F428 PREDICTED: similar to Src homology 2 domain containing E n=1
           Tax=Macaca mulatta RepID=UPI0000D9F428
          Length = 199

 Score = 77.4 bits (189), Expect = 8e-13,   Method: Compositional matrix adjust.
 Identities = 40/71 (56%), Positives = 51/71 (71%), Gaps = 2/71 (2%)

Query: 147 MAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWE 206
           +A+ R SK+   +P  LYDTPYEP E G  AEG+  P   +SRLPE+DERP  EY+QPWE
Sbjct: 54  LAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKARP--PDSRLPENDERPAAEYEQPWE 111

Query: 207 WKKERISKAFA 217
           WKKE+I +A +
Sbjct: 112 WKKEQIVRALS 122


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score = 73.9 bits (180), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 45/122 (36%), Positives = 70/122 (57%), Gaps = 9/122 (7%)

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSL 359
           S+  + P+ +   P     ++ WYHG +SR++ E LL    K+  YL+RNSE+   DFSL
Sbjct: 258 SLNTNPPIVKDETPDCIFRDKDWYHGTLSRSECEFLLNEHAKDGEYLIRNSESKPGDFSL 317

Query: 360 SLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH---MSLLY 416
           S+K+     H K+     ++YV+GQ S  FS++ E++ HY  +  PI   E+   M LLY
Sbjct: 318 SMKAPNRIKHFKI-LYGNNQYVIGQRS--FSNIDELLSHY--KNYPIYTTENGQKMHLLY 372

Query: 417 PV 418
           P+
Sbjct: 373 PL 374


>UniRef50_UPI0001925BB9 PREDICTED: similar to Shb=Src homology 2 protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001925BB9
          Length = 419

 Score = 69.3 bits (168), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 83/310 (26%), Positives = 126/310 (40%), Gaps = 68/310 (21%)

Query: 82  WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
           W + +      L ++    P    +DY+DP+D ++    S            +D Y EPY
Sbjct: 149 WDTFSGKNKKDLENKQNSVPTKKKDDYSDPWDSKKCTSKSYDEF--------DDTYSEPY 200

Query: 142 EAQK---MMAEIRGSKETATQPLPLYDTPYE--------PEEDGATAEG---------EG 181
           +  K   M +    S+    +   LYD PYE        P+ +G              + 
Sbjct: 201 DKNKHTVMDSTPHASESDVEEHAELYDMPYEERVILGVEPKINGNLKNPAPHLQPVPPQH 260

Query: 182 APWPRESRLPEDDERPPE-EYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
           AP+      P     P   EYD PWEWK + +   F     V            ++S+ S
Sbjct: 261 APYSSAKPKPSSSILPTAGEYDAPWEWKMKDVEADFEKRFSV-----------GVESASS 309

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNP-----K 295
           +               +P L  S      P K  +   R +           NP     +
Sbjct: 310 I---------------KPPLNSSH-----PNKKPVPAVRNQSITSINTAVVANPVQKPAR 349

Query: 296 SAKPLSMEPSSPLG--EW-TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
           S K +S+  +  L   E+  DP +PL+NQ W+HGAI R  AE+LL+   + SYL+R+SE+
Sbjct: 350 SNKDVSVSKAEDLSRKEYEVDPTIPLKNQGWFHGAIRRDYAEDLLKSMPDCSYLIRDSES 409

Query: 353 SKNDFSLSLK 362
           SK ++SLSLK
Sbjct: 410 SKLNYSLSLK 419


>UniRef50_UPI0000E49F60 PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49F60
          Length = 514

 Score = 67.4 bits (163), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 65/237 (27%), Positives = 94/237 (39%), Gaps = 98/237 (41%)

Query: 191 PEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISG 250
           PE D RP +EYD PWEW                  +P    + Q     ++ D ++  +G
Sbjct: 372 PESDTRPGDEYDAPWEW------------------MPMNRKLSQ-----AITDKEKHHAG 408

Query: 251 PASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK---SAKPLSMEPSSP 307
             SPLPE                  +P R  K         GN K    ++P+ M     
Sbjct: 409 RISPLPE------------------TPTRGAK--------KGNMKLDIKSRPVEMP---- 438

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
            GE  DP +PL +Q                                         S++GF
Sbjct: 439 -GEPVDPNIPLTHQT----------------------------------------SAKGF 457

Query: 368 MHMKLSRTKEHK-YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           MHMK+    +   Y+LG+ S PF S+ E++ +Y  +KL I+GAEHM+LL+PV  + L
Sbjct: 458 MHMKIVFNHQSDGYILGEFSKPFPSISEMICYYTRQKLNIRGAEHMALLHPVIDQLL 514


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score = 64.7 bits (156), Expect = 6e-09,   Method: Compositional matrix adjust.
 Identities = 33/84 (39%), Positives = 51/84 (60%), Gaps = 2/84 (2%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           + ++N  WY+G I+R DAE LL    E ++L+R SE+S  DFSLS+K   G  H K+ R 
Sbjct: 53  IEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRD 112

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHY 399
            + K+ L      F+S+ E+V ++
Sbjct: 113 AQSKFFLW--VVKFNSLNELVEYH 134


>UniRef50_A1L1W5 Zgc:158464 n=2 Tax=Danio rerio RepID=A1L1W5_DANRE
          Length = 208

 Score = 64.7 bits (156), Expect = 7e-09,   Method: Compositional matrix adjust.
 Identities = 32/54 (59%), Positives = 37/54 (68%), Gaps = 3/54 (5%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKE 155
           L ILEDYADPFD     + + G     EK PENDGYMEPYEAQKMMA ++  K+
Sbjct: 136 LIILEDYADPFDA---ADQAGGTQTTTEKPPENDGYMEPYEAQKMMAVLQTQKQ 186


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score = 64.3 bits (155), Expect = 9e-09,   Method: Compositional matrix adjust.
 Identities = 34/92 (36%), Positives = 53/92 (57%), Gaps = 3/92 (3%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG +SR+ AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 161 YITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHY 220

Query: 371 KLSRTKEHK-YVLGQNSPPFSSVPEIVHHYAS 401
           +++ T + K YV  ++   FS++ E+VHH+++
Sbjct: 221 RINTTADGKVYVTAESR--FSTLAELVHHHST 250


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score = 62.0 bits (149), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 34/92 (36%), Positives = 50/92 (54%), Gaps = 1/92 (1%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG ISR  AE LL    + S+LVR+SE+S    S+SL+      H 
Sbjct: 175 YVTPFNSLEKHSWYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGHRSISLRFDGRVYHY 234

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
           ++S   + K  +   S  FS++ E+VHH+  +
Sbjct: 235 RISSGSDGKVFVTTES-KFSTIAELVHHHCKQ 265


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score = 61.6 bits (148), Expect = 5e-08,   Method: Compositional matrix adjust.
 Identities = 39/95 (41%), Positives = 56/95 (58%), Gaps = 6/95 (6%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY+G ++R  AE  L     E  +L+R+SE+S NDFS+SLK+     H K+ + KE  Y 
Sbjct: 85  WYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKV-QLKETVYC 143

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           +GQ    FS++ E+V HY  +K PI  +E    LY
Sbjct: 144 IGQRK--FSTMEELVEHY--KKAPIFTSEQGEKLY 174


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score = 61.2 bits (147), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 5/109 (4%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H
Sbjct: 249 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYH 308

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYP 417
            ++S   + K  + Q +  F+++ E+VHH++   +P +G   ++ LLYP
Sbjct: 309 YRISEDPDGKVFVTQEA-KFNTLAELVHHHS---VPHEGHGLITPLLYP 353


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score = 61.2 bits (147), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 38/97 (39%), Positives = 57/97 (58%), Gaps = 6/97 (6%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY+G ++R  AE  L     E  +L+R+SE+S +DFS+SLK+S    H K+    ++ Y 
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLV-DNVYC 343

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +GQ    F ++ E+V HY  +K PI  +EH   LY V
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score = 61.2 bits (147), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 5/109 (4%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H
Sbjct: 241 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYH 300

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYP 417
            ++S   + K  + Q +  F+++ E+VHH++   +P +G   ++ LLYP
Sbjct: 301 YRISEDPDGKVFVTQEA-KFNTLAELVHHHS---VPHEGHGLITPLLYP 345


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score = 61.2 bits (147), Expect = 7e-08,   Method: Compositional matrix adjust.
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 5/109 (4%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H
Sbjct: 260 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYH 319

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYP 417
            ++S   + K  + Q +  F+++ E+VHH++   +P +G   ++ LLYP
Sbjct: 320 YRISEDPDGKVFVTQEA-KFNTLAELVHHHS---VPHEGHGLITPLLYP 364


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score = 61.2 bits (147), Expect = 8e-08,   Method: Compositional matrix adjust.
 Identities = 35/98 (35%), Positives = 53/98 (54%), Gaps = 7/98 (7%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  PA  L    WYHGA+SR  AE LL      S+LVR+SE+ +   S+S++ +    H 
Sbjct: 75  YITPATSLNMHTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGHLSVSVRFNASVYHY 134

Query: 371 KLSRTKEHKYVLGQNSPP--FSSVPEIVHH--YASRKL 404
           +++      + +   SP   F ++PE+VHH  YAS  L
Sbjct: 135 RINVDTAGLFYI---SPEHRFQTLPELVHHHSYASDGL 169


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score = 60.5 bits (145), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 5/109 (4%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H
Sbjct: 240 NYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYH 299

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYP 417
            ++S   + K  + Q +  F+++ E+VHH++   +P +G   ++ LLYP
Sbjct: 300 YRISEDPDGKVFVTQEA-KFNTLAELVHHHS---VPHEGHGLITPLLYP 344


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score = 59.7 bits (143), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 34/100 (34%), Positives = 58/100 (58%), Gaps = 12/100 (12%)

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS-YLVRNSETSKNDFSL 359
           S  PSS +G          ++ W+HG I+R D+E +L    E+  +L+R SET   DF++
Sbjct: 277 SFTPSSSVG--------FYDRDWFHGRITRQDSEKILGCPGESGLFLIRESETMPGDFAV 328

Query: 360 SLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           S+K+ +   H K++R+ + K+ +GQ    F S+ ++V HY
Sbjct: 329 SVKAPERVKHFKVTRS-DKKFCIGQRK--FESLDDLVDHY 365


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score = 59.3 bits (142), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG +SR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 115 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 174

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +++   + K  +   S  F+++ E+VHH+++
Sbjct: 175 RINTASDGKLYVSSES-RFNTLAELVHHHST 204


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score = 58.9 bits (141), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 29/90 (32%), Positives = 49/90 (54%), Gaps = 1/90 (1%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   L+   WYHG ISR+D+E +L      S+LVR SETS   +++S++      H 
Sbjct: 182 FIAPYNSLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHY 241

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           +++     K  + Q    F ++ E+VHH++
Sbjct: 242 RINVDNTEKMFITQ-EVKFRTLGELVHHHS 270


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score = 58.5 bits (140), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 34/100 (34%), Positives = 54/100 (54%), Gaps = 5/100 (5%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LE++ WYHGAI R+ AE LL      S+L+R SE+     ++SL+      H ++ R   
Sbjct: 162 LESEKWYHGAIQRSYAEYLLNSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDDS 221

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           + Y + + S  F+SV ++VHH+      +      +LLYP
Sbjct: 222 NMYYVIE-SNKFTSVSDLVHHHEKHSDGLA----CTLLYP 256


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score = 58.5 bits (140), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 34/91 (37%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 185 YVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHY 244

Query: 371 KLSRTKEHK-YVLGQNSPPFSSVPEIVHHYA 400
           ++S   + K YV  +    F+++ E+VHH++
Sbjct: 245 RISEDSDGKVYVTAE--AKFNTLAELVHHHS 273


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score = 58.5 bits (140), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG +SR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 1   YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 60

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +++   + K  +   S  F+++ E+VHH+++
Sbjct: 61  RINTASDGKLYVSSES-RFNTLAELVHHHST 90


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score = 57.8 bits (138), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 31/90 (34%), Positives = 45/90 (50%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 162 YVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 221

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           +++       V       F+++ E+VHH++
Sbjct: 222 RINEDTSDGKVYVTTESRFNTLAELVHHHS 251


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score = 57.8 bits (138), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG +SR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 454 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 513

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +++   + K  +   S  F+++ E+VHH+++
Sbjct: 514 RINTASDGKLYVSSES-RFNTLAELVHHHST 543


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score = 57.4 bits (137), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 44/154 (28%), Positives = 75/154 (48%), Gaps = 4/154 (2%)

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
           ++GP+    +P+L  +   F     + LS  + EK R+      G    A+  + +   P
Sbjct: 307 LAGPSEN--DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP 364

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
              +  P   LE   WYHG +SR  AE+LL      S+LVR SE+S    S+SL+     
Sbjct: 365 -SNYITPVNSLEKHSWYHGPVSRNAAEHLLSSGINGSFLVRESESSPGQRSISLRYEGRV 423

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
            H +++   + K  +   S  F+++ E+VHH+++
Sbjct: 424 YHYRINTASDGKLYVSSES-RFNTLAELVHHHST 456


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score = 57.0 bits (136), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 28/86 (32%), Positives = 50/86 (58%), Gaps = 3/86 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +E + WY G I R +AE  L L   +  ++LVR+SE+ +NDFSLS++      H ++ + 
Sbjct: 142 IEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFSLSVRDGDTVKHYRIRQL 201

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYAS 401
            E  + + + +  F ++ E+V HY +
Sbjct: 202 DEGGFFIARRT-TFRTLQELVDHYGN 226


>UniRef50_A6NKC9 SH2 domain-containing protein 7 n=4 Tax=Euteleostomi
           RepID=SH2D7_HUMAN
          Length = 451

 Score = 57.0 bits (136), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 1/82 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG I+R   E LLR     S+L+R S+ +   + LS + S    H  +++ +  +Y++
Sbjct: 51  WFHGFITRKQTEQLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYII 109

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
             ++   S++ E+VHHY   +L
Sbjct: 110 SGDTQSHSTLAELVHHYQEAQL 131


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score = 56.6 bits (135), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 28/83 (33%), Positives = 51/83 (61%), Gaps = 3/83 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           LE + W+ G ISR +A  +L++ K E  +LVR SET   +++LSL  ++G  H ++    
Sbjct: 340 LEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEGVRHYRIQHI- 398

Query: 377 EHKYVLGQNSPPFSSVPEIVHHY 399
           E +Y + +N   F S+P+++ ++
Sbjct: 399 EGQYFVNENH-RFDSIPQLIEYH 420


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score = 56.2 bits (134), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 34/97 (35%), Positives = 57/97 (58%), Gaps = 6/97 (6%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY+G ++R  AE +L +   +  +L+R+SE+  NDFS+SLK+     H K+    +  + 
Sbjct: 236 WYYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISLKALYKNKHFKV-LLNDGFFC 294

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +GQ    FS++ ++V HY  +K PI  +EH   LY +
Sbjct: 295 IGQR--KFSTMEDLVEHY--KKAPIFTSEHGDKLYLI 327


>UniRef50_UPI0000E48AB6 PREDICTED: similar to B-cell linker n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E48AB6
          Length = 591

 Score = 56.2 bits (134), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 48/174 (27%), Positives = 79/174 (45%), Gaps = 19/174 (10%)

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL-SMEPSSPLGEWT 312
           PLP+ +   S  Q   P +S +    E       RL+   P    P  S  P SP     
Sbjct: 418 PLPQGTRRPSQPQLPMPNQSSVHQINE-------RLAPSQPAKPAPSGSRAPPSPSRVHV 470

Query: 313 DPALP-----LENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSK--NDFSLSLKSS 364
            PA P     LE   WY+G I R ++E  L  C K+ +++VRNS      N +SL+L  +
Sbjct: 471 PPAQPQQVNELEGHPWYNGGIGRQESEKYLHQCRKDGAFIVRNSTRGDPANPYSLALWFN 530

Query: 365 QGFMHMKLSRTKEHKYVLG---QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
               ++++ + K+ +Y LG    N   F +  +++ H+ +  L +   E  ++L
Sbjct: 531 GRVRNLQIRKRKDQRYALGSRKDNELAFDTPVQLIEHHMTNSLILAQDEGKTIL 584


>UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=1 Tax=Ciona intestinalis
           RepID=UPI0000523E1B
          Length = 322

 Score = 55.8 bits (133), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 28/84 (33%), Positives = 50/84 (59%), Gaps = 3/84 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           ++ Q+WY G++ R  AE +L+   E ++LVRNS++   DF LS+K  +  +H  + R  E
Sbjct: 9   MQQQIWYFGSLERIVAEQILQPTSEGTFLVRNSKSILGDFVLSVKQKEEVIHYIIRR--E 66

Query: 378 HKYVLGQNSPPFSSVPEIVHHYAS 401
           H  ++ +N   F S+  ++ HY +
Sbjct: 67  HSKLVLKNH-VFLSMVTLLEHYKT 89


>UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2C7_MONBE
          Length = 592

 Score = 55.8 bits (133), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 28/98 (28%), Positives = 58/98 (59%), Gaps = 2/98 (2%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           +YHG ISR +A   L+ +  + ++L+R S T K+ +++SL+S+    H++++ T    Y 
Sbjct: 433 YYHGTISREEAVRRLQEVNTDGAFLLRLSATQKDAYTISLQSNGEIKHIRVTNTSNGGYA 492

Query: 382 LGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
           LG++   F S+ +++     + L   KG + + L++P+
Sbjct: 493 LGKSKEEFESIWDLIEAQLDKSLKSTKGDQAVQLVHPL 530


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score = 55.8 bits (133), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 33/96 (34%), Positives = 51/96 (53%), Gaps = 5/96 (5%)

Query: 318 LENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           LE+  W+ G I+R+ AE  L    C   S+L+R SE+S   +SLSL+      H ++   
Sbjct: 232 LESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRDGDTVRHYRVENY 291

Query: 376 KEHKYVLGQNSPP--FSSVPEIVHHYASRKLPIKGA 409
           +   Y L Q SP   F+S+PE++  +  RK  +  A
Sbjct: 292 EGGLYKL-QGSPTQKFASLPELIAFHGQRKAGLATA 326


>UniRef50_UPI000180B9A8 PREDICTED: similar to Protein vav-2 n=1 Tax=Ciona intestinalis
           RepID=UPI000180B9A8
          Length = 938

 Score = 55.5 bits (132), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 29/85 (34%), Positives = 48/85 (56%), Gaps = 4/85 (4%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           A+PLE  +WY G + R +AENLL      ++LVR   T     ++SL  S+   H++++R
Sbjct: 730 AIPLEENIWYAGTMDRGEAENLLHDKPSGTFLVR---TRDGHLAISLIYSKEMKHIRINR 786

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHY 399
           + E  Y + +    F SV E++ +Y
Sbjct: 787 SSEGLYFVAE-CKNFKSVQELIRYY 810


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score = 55.1 bits (131), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 3/86 (3%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +P+E Q WY G ISR  AE+LL   +E  +LVR+SE++  D S+S++  +   H K+   
Sbjct: 294 IPMEQQPWYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQNV 353

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYAS 401
                +L   +  F  +  +++HY +
Sbjct: 354 DG---LLKIGNRTFVDMNALINHYTT 376


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score = 54.3 bits (129), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 32/102 (31%), Positives = 58/102 (56%), Gaps = 6/102 (5%)

Query: 318 LENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           L  + WY+GAI+R+  + +L     +  +L+R+SET+  D+S+SLK+     H ++   +
Sbjct: 443 LAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRV-HVE 501

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           ++ Y +GQ    F S+ ++V HY  ++ PI   +    LY V
Sbjct: 502 QNMYCIGQRK--FHSLDQLVDHY--QRAPIYTNKQGEKLYLV 539


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score = 53.9 bits (128), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 29/88 (32%), Positives = 45/88 (51%), Gaps = 5/88 (5%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKEAS---YLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           EN  W+HG ISR DAE +LR  +E S   +LVR S +S+ D+ LS+      +H  + R 
Sbjct: 5   ENLCWFHGKISREDAEEILR--REGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRH 62

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRK 403
            +  +    +  P   +  ++ HY   K
Sbjct: 63  GDDAFFSIHDHTPIHGLDSLIEHYQKDK 90


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score = 53.9 bits (128), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 26/89 (29%), Positives = 53/89 (59%), Gaps = 3/89 (3%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEA-SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P E ++W+HG IS+ +A NLL    +  S+LVR S+ +  D+SL  ++++     K+  T
Sbjct: 345 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 404

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
             +++++G     ++S+ +I+ HY   ++
Sbjct: 405 PNNQFMMG--GRYYNSIGDIIDHYRKEQI 431



 Score = 52.4 bits (124), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 40/113 (35%), Positives = 58/113 (51%), Gaps = 13/113 (11%)

Query: 313 DPALPLE----NQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGF 367
           + A+PL     NQ WYHG + RT AE  LR   K  SYL+R S+     F LS  S    
Sbjct: 168 EVAIPLTAPPTNQ-WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNV 226

Query: 368 M-HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           + H ++       Y+ G+    FSS+ +++ +Y+     +KG +   LLYPVA
Sbjct: 227 VNHFRIIAMCGDYYIGGRR---FSSLSDLIGYYSHVSCLLKGEK---LLYPVA 273


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score = 53.9 bits (128), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 30/80 (37%), Positives = 43/80 (53%), Gaps = 3/80 (3%)

Query: 323 WYHGAISRTDAENLLRLC--KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           W+ GAI R+DAE  L     K  S+L+R SE+ K +FSLS+       H ++ R  E  +
Sbjct: 116 WFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGF 175

Query: 381 VLGQNSPPFSSVPEIVHHYA 400
            L +    FS++ E V HY 
Sbjct: 176 FLTRRR-IFSTLNEFVSHYT 194


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score = 53.9 bits (128), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 38/126 (30%), Positives = 62/126 (49%), Gaps = 12/126 (9%)

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRLC--KEASYLVRNSETSK----NDFSLSLK 362
           G +  P   LE + WY G I R DAE LL     ++ S+L+R SE       N F+LS++
Sbjct: 115 GNYVAPIQTLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVR 174

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY--ASRKLPIKGAE---HMSLLYP 417
             +   H ++  T   KY +   S  FS++ E++  Y  +S  L IK  E    + +++ 
Sbjct: 175 DKELIRHYRIKITDSGKYFISL-SKEFSTLNELIEFYKISSDGLKIKLLEPCRKVCIMFK 233

Query: 418 VAIRTL 423
             ++T 
Sbjct: 234 KQVQTF 239


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score = 53.5 bits (127), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 5/95 (5%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMKLSRTK 376
           LE+Q WYHG +SR D E L  L K   +LVR ++    +   LS+   +  +H+ ++ T+
Sbjct: 718 LEDQHWYHGLLSREDIEKL--LVKNGDFLVRVTDNQGVHQIVLSIHVGERNIHLTIAVTE 775

Query: 377 EHKYVLG--QNSPPFSSVPEIVHHYASRKLPIKGA 409
           +  + L   +  P F S+ ++V +Y   K+ IK A
Sbjct: 776 DGHFQLSVLRRGPRFPSIYDLVQYYKMHKIKIKDA 810


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score = 53.5 bits (127), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 11/117 (9%)

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSL 361
           PS+ + E+      L+ + W+ G I R +AE +L     +  S+L+R+SET+  DFSLS+
Sbjct: 107 PSNYVAEYK----SLDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSV 162

Query: 362 KSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           K      H ++ R ++    + + S  F  + E+V HY   K+   G     LLYP 
Sbjct: 163 KDQDRVRHYRVRRLEDGSLFVTRRS-TFQILHELVDHY---KIETDGL-CCKLLYPC 214


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score = 53.5 bits (127), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 35/97 (36%), Positives = 54/97 (55%), Gaps = 8/97 (8%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLS- 373
           L +E   WYHG +SR  AE LL    E  SYL+R+S T   ++SLS+K      H ++  
Sbjct: 7   LEVEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSVKHFQIGW 66

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
             K++++ +G     F S+ E V H+A++  P+ G E
Sbjct: 67  DGKQYQFGMG----VFQSLQEFVEHFANQ--PLIGGE 97


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score = 53.1 bits (126), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 36/113 (31%), Positives = 59/113 (52%), Gaps = 8/113 (7%)

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
           SP+G+  +   PLE Q WYHGAI R + + L  L K+  +LVR S+  K  + LS+  S 
Sbjct: 513 SPVGQEVER--PLEQQTWYHGAIPRLEVQQL--LTKDGDFLVRKSQ-EKPGYVLSVHWSG 567

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
              H  L + K++ Y L  +   F ++P+++  Y + +  +     + L  PV
Sbjct: 568 ACKHF-LVQNKDNMYCL--DGESFHTIPQLIQQYQTSQQHVTKKSEVVLRRPV 617


>UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containing 4B n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A0859
          Length = 488

 Score = 53.1 bits (126), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 26/90 (28%), Positives = 48/90 (53%), Gaps = 1/90 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ISR DAE+LL    E ++LVR SE     ++LS +  +GF H  +  + +    L
Sbjct: 382 WFHGIISREDAEDLLENMTEGAFLVRVSEKIWG-YTLSYRLQKGFKHFLVDASGDFYSFL 440

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           G +    +++ +++  +    + + G E +
Sbjct: 441 GVDPNRHATLTDLIDFHKEEIITVSGGELL 470


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score = 52.8 bits (125), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 28/87 (32%), Positives = 50/87 (57%), Gaps = 2/87 (2%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEA-SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P E +VWYHG I++ +A NLL    +  S+LVR S+ +  D+SL  +++      K+S T
Sbjct: 353 PHEGKVWYHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRTNDIIQRFKISPT 412

Query: 376 KEHKYVL-GQNSPPFSSVPEIVHHYAS 401
             ++Y++ G+    +  +  + HH+ S
Sbjct: 413 SNNQYMMGGRYYNRYEPICMLGHHFQS 439



 Score = 47.4 bits (111), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 8/99 (8%)

Query: 323 WYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFM-HMKLSRTKEHKY 380
           WYHG + RT AE  LR  +   SYL+R S+     F LS  S    + H ++       Y
Sbjct: 185 WYHGKLDRTIAEERLRQARNPGSYLIRESDRRPGSFVLSFLSMTNVVNHFRIIAMCGDYY 244

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           + G+    FSS+ +++ +Y+     +KG +   LL PVA
Sbjct: 245 IGGRR---FSSLSDLIGYYSYVSCLLKGEK---LLSPVA 277


>UniRef50_UPI0001555700 PREDICTED: similar to hCG34612 n=1 Tax=Ornithorhynchus anatinus
           RepID=UPI0001555700
          Length = 333

 Score = 52.4 bits (124), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 55/187 (29%), Positives = 85/187 (45%), Gaps = 28/187 (14%)

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPS-- 305
           +SGPA  +P+   E+ S   +G    CL          PP  S G P +++P +  PS  
Sbjct: 157 VSGPAETVPKG--EEWSMSLQGFVPVCLPK--------PPPFSHGFPAASRPAAPSPSLS 206

Query: 306 --SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET--SKNDFSLSL 361
             SP     DP++    Q WY     R  AE++L L K+ +++VR S        F+L++
Sbjct: 207 RVSPWCCVQDPSI--LTQPWYADPCDRQTAESVLLLQKDGAFIVRPSSNPGGSQPFTLAV 264

Query: 362 KSSQGFMHMKLSRTKEHK-YVLGQNSPP----FSSVPEIVHHYASRKLPI----KGAEHM 412
                  ++ + R    + Y LG+        FSSV  IV HY+ + LP+     GA   
Sbjct: 265 LLHNRVYNVPIRRLDGGRHYALGREGKIREELFSSVAAIVKHYSRKPLPLVDRHTGARQF 324

Query: 413 S-LLYPV 418
           + LL+P 
Sbjct: 325 TCLLFPT 331


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 52.4 bits (124), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 32/99 (32%), Positives = 55/99 (55%), Gaps = 5/99 (5%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+H +++ + AE LL    + S+LVR SE+   DF++S+K +    H+K+    +   ++
Sbjct: 5   WFHSSLNGSQAEELLTPLADGSFLVRPSESKHGDFTISVKCNGKVTHIKIQNDGDSFLLI 64

Query: 383 GQNSP-PFSSVPEIVHHYAS--RKLPIKGAEHMSLLYPV 418
           G  SP PF ++  +V HY +    +  K    + LLYPV
Sbjct: 65  G--SPDPFPTLESLVSHYRNTPNSIKEKSGVFIELLYPV 101



 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 27/79 (34%), Positives = 45/79 (56%), Gaps = 3/79 (3%)

Query: 323 WYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WYHG+I   +AE  LL   +  SYLVR S++    F L +K + G   + +S  +  KY 
Sbjct: 111 WYHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQVIIS-CRNKKYE 169

Query: 382 LGQNSPPFSSVPEIVHHYA 400
           + ++ P F+S+ E++ +Y 
Sbjct: 170 I-KSGPSFASLQELIEYYV 187


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score = 52.4 bits (124), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 4/102 (3%)

Query: 319 ENQVWYHGAISRTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           E+  WYHG +SR   ENLL+     + S+LVR S +S  DF LS+  +    H ++ R  
Sbjct: 5   EDIFWYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHS 64

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           E  +     +     +  ++ HY + K  +  +E +SL  PV
Sbjct: 65  EDAFFSIDENTKIHGLESLIEHYVNTKGIL--SEGLSLTVPV 104



 Score = 42.0 bits (97), Expect = 0.043,   Method: Compositional matrix adjust.
 Identities = 32/124 (25%), Positives = 59/124 (47%), Gaps = 11/124 (8%)

Query: 279 REEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR 338
           R++  +LP  L+  N        +E +  L  +  PA       WYHG + R +AE  ++
Sbjct: 248 RDKDNQLPSHLARKNG------FIECAEILENYQCPAPKTHRSYWYHGTLDRHEAETTIK 301

Query: 339 L--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
               K+ ++LVR S+ +K +  L+L +   F +  +   K+  Y+   N P   S+  I+
Sbjct: 302 QFSTKDGTFLVRWSDRNK-ERVLTLINESLFYNYIIR--KQDDYLFIDNGPYLESLEHII 358

Query: 397 HHYA 400
            +Y+
Sbjct: 359 EYYS 362


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score = 52.0 bits (123), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 26/91 (28%), Positives = 48/91 (52%), Gaps = 3/91 (3%)

Query: 311 WTDPALPLENQVWYHGAISRTDAEN--LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
           +  P    E + WY G + R +AE   ++R     ++L+R +ET+  +FSLS++      
Sbjct: 114 YVAPEKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLSVRDGDSVK 173

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           H ++ +     Y +   + PF+S+ E+V HY
Sbjct: 174 HYRVRKLDTGGYFITTRA-PFNSLYELVQHY 203


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score = 52.0 bits (123), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 3/82 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYHG I+R   E++L   K   +LVR+S T K  + LS+  +    H  ++  K  +Y +
Sbjct: 10  WYHGDITRPACESILMAQKPGLFLVRDSSTCKGGYVLSVSENNKVSHYIITN-KNSQYQI 68

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
           G  +  F+ +PEIV  Y    L
Sbjct: 69  GDQT--FNDLPEIVEFYKRHFL 88


>UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Euteleostomi
           RepID=SH24B_HUMAN
          Length = 431

 Score = 52.0 bits (123), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 27/88 (30%), Positives = 46/88 (52%), Gaps = 1/88 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ISR DAE LL    E ++LVR SE     ++LS +  +GF H  +  + +    L
Sbjct: 325 WFHGIISREDAEALLENMTEGAFLVRVSEKIWG-YTLSYRLQKGFKHFLVDASGDFYSFL 383

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAE 410
           G +    +++ ++V  +    + + G E
Sbjct: 384 GVDPNRHATLTDLVDFHKEEIITVSGGE 411


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score = 51.6 bits (122), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 35/104 (33%), Positives = 50/104 (48%), Gaps = 8/104 (7%)

Query: 317  PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSS--QGFMHMKLSR 374
            PL  + W+HG + R +   LLR   E  +LVR  ET++ND S ++ S    G  H  +  
Sbjct: 945  PLHEEEWFHGVLPREEVVRLLR--NEGDFLVR--ETTRNDESQTVLSVCWNGHKHFIVQT 1000

Query: 375  TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            T E  Y      P F S+ E++ H    +LP+ G     L  PV
Sbjct: 1001 TAEGHYRF--EGPAFPSIQELIVHQYQSELPVTGRSGAVLRKPV 1042


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score = 51.6 bits (122), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 33/107 (30%), Positives = 53/107 (49%), Gaps = 4/107 (3%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           D +  ++ Q W+HG I RT++  LL+  ++  +L+R S  S  DF LS K+     H K+
Sbjct: 460 DQSKTIKEQTWFHGTIPRTESLRLLQ--QDGDFLLRESNNSLGDFVLSAKADGQVRHFKV 517

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
             T    Y    +  P + +  I HHY  R+ P+    +  LL P+ 
Sbjct: 518 QVTDNGMYRFEADQFP-TVLNLISHHYQKRE-PVTKRTNCLLLNPIC 562


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score = 51.2 bits (121), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 55/97 (56%), Gaps = 6/97 (6%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY+G+I+R   +NLL +   +  +L+R+SET+  D+S+SLK+     H ++   +   Y 
Sbjct: 312 WYYGSITRYMCDNLLNQRGHDGDFLIRDSETNVGDYSVSLKAPGRNKHFRV-HVEGALYC 370

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +GQ    F ++ ++V HY  ++ PI   +    LY V
Sbjct: 371 IGQRK--FHTLDQLVDHY--QRAPIYTNKQGEKLYLV 403


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score = 51.2 bits (121), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 26/88 (29%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           P  ++ W+H  +SR  AENLL   +   +++R S++S  DFS+S++      H K+ R  
Sbjct: 26  PFSSKRWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDN 85

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +  Y L   +  F S+ ++V +Y +  +
Sbjct: 86  KGNYFLW--TEKFPSLNKLVDYYRTNSI 111


>UniRef50_UPI00019255F9 PREDICTED: similar to V-crk sarcoma virus CT10 oncogene homolog n=1
           Tax=Hydra magnipapillata RepID=UPI00019255F9
          Length = 249

 Score = 51.2 bits (121), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYH  ISR +A+ LL  CK  S+LVR  +   N++ LS+   Q   H  +       + +
Sbjct: 11  WYHNTISREEAQTLLNGCKLGSFLVRRRKGVSNEYVLSVSEKQKISHYIIMDVNGMYFKI 70

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
           G+    F+ +  I+  Y    +
Sbjct: 71  GEQR--FADIASIIEFYKQHTI 90


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score = 51.2 bits (121), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 5/88 (5%)

Query: 323 WYHGAISRTDAENLLRLCK---EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           W+HG ISR  A  L++L        +LVR SET + ++ L+        H++LS T+  +
Sbjct: 388 WFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLTFNFQGRAKHLRLSLTERGQ 447

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIK 407
             +      FSS+ E++HH+    +P++
Sbjct: 448 CRVQHLR--FSSITEMLHHFHRYPIPLE 473


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score = 51.2 bits (121), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 6/88 (6%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSL----KSSQGFMHMK 371
           L L N+ W+HG I R +AENLL+  +  ++L+R SET K  ++L++      ++   H +
Sbjct: 61  LDLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKGSYTLTMIQIKDGTKQISHFR 120

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           ++   + KY +  ++  F  + +++ HY
Sbjct: 121 INY-DDGKYFI-TSARRFLGLHQLIQHY 146


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score = 51.2 bits (121), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 25/82 (30%), Positives = 42/82 (51%), Gaps = 1/82 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           EN  W+HG ISR  AE +LR    +  ++VR S +S+ DF LS+      +H ++ R  +
Sbjct: 5   ENLCWFHGKISRERAEEILRQEGGDGVFMVRESASSEGDFVLSVLFQDEMVHYQIRRHGD 64

Query: 378 HKYVLGQNSPPFSSVPEIVHHY 399
             +    +  P   +  ++ HY
Sbjct: 65  DAFFSIDDHTPIHGLESLIEHY 86


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score = 51.2 bits (121), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 25/85 (29%), Positives = 48/85 (56%), Gaps = 3/85 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +E + WY   I R +AE  L L   +  ++L+R+SE+  ND+SLS++      H ++ + 
Sbjct: 125 IEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQL 184

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYA 400
            E  + + + +  F ++ E+V HY+
Sbjct: 185 DEGGFFIARRT-TFRTLQELVEHYS 208


>UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Ciona intestinalis
           RepID=UPI000180C238
          Length = 295

 Score = 50.8 bits (120), Expect = 9e-05,   Method: Compositional matrix adjust.
 Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 3/82 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WY G +SR D++N L   K  S+LVR+S T   D+ LS+  +    H  +++ +E++  +
Sbjct: 14  WYFGMVSRKDSQNKLLHQKHGSFLVRDSTTCPGDYVLSVSENSKVSHYIINK-QENRLKI 72

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
           G     F S+PE++  Y    L
Sbjct: 73  GDQM--FDSMPELLDFYKVHYL 92


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score = 50.8 bits (120), Expect = 9e-05,   Method: Compositional matrix adjust.
 Identities = 28/78 (35%), Positives = 45/78 (57%), Gaps = 3/78 (3%)

Query: 323 WYHGAISRTDAENL-LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+HG +S  +AE L L   K  S+LVR S++   DF LS+++     H+ + R  E+KY 
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRTEDKVTHVMI-RWHENKYD 116

Query: 382 LGQNSPPFSSVPEIVHHY 399
           +G     F ++ E++ HY
Sbjct: 117 VG-GGQKFGTLCELIEHY 133


>UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7Q1P4_IXOSC
          Length = 461

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 33/104 (31%), Positives = 50/104 (48%), Gaps = 17/104 (16%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL----- 372
           LE + W+HGAISR ++E   RL ++  +LVR S+ +   F L+        H+ L     
Sbjct: 361 LEKEAWFHGAISRKESEG--RLAEDGDFLVRESQGNPGQFVLTGMQGSARRHLLLVDPAG 418

Query: 373 -SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
             RTK+           F SV  +V+++    LPI  AE   +L
Sbjct: 419 VVRTKDRT---------FDSVSHLVNYHRDNALPIISAESALVL 453


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 34/112 (30%), Positives = 60/112 (53%), Gaps = 18/112 (16%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL----- 372
           L+ ++W+HG++SR +AE++L   ++  +LVR S+ S   + L+  ++    H+ L     
Sbjct: 341 LKQEIWFHGSVSRAEAESMLT--RDGDFLVRESQGSPGQYVLTGMNNNTPKHLLLIDPEG 398

Query: 373 -SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL-YPVAIRT 422
             RTK+           F SV  +V+H+    LPI  A+ + +L YP+  RT
Sbjct: 399 VVRTKDR---------VFDSVSHLVNHHCDNVLPIISADSVLVLRYPIPRRT 441


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 3/98 (3%)

Query: 305 SSPLGEWTDPALPLENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKS 363
           ++ +G     A  + ++ WY G + R DAE  L+       +LVR SETS  D+S+S+K 
Sbjct: 298 NTAIGGNDGAADGIHSRDWYFGNMKRADAEQRLQDRADNGEFLVRGSETSSGDYSISMKM 357

Query: 364 SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
                H K++      + +GQ    F S+  ++ HY S
Sbjct: 358 PGRIRHFKVNTLPNGVFGIGQRK--FDSMDALLEHYKS 393


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 33/100 (33%), Positives = 57/100 (57%), Gaps = 8/100 (8%)

Query: 318 LENQVWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           L++  WYHG ++R  AE LL    C + SYL+R+S  +   +SLS+++     H  +  T
Sbjct: 30  LQDLGWYHGNLTRHAAEALLLSNGC-DGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT 88

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
             + +  G N   FSS+ + V H+A++  P+ G+E  +L+
Sbjct: 89  G-YSFKFGFN--EFSSLKDFVKHFANQ--PLIGSETGTLM 123


>UniRef50_C3XTW6 Putative uncharacterized protein n=4 Tax=Branchiostoma floridae
           RepID=C3XTW6_BRAFL
          Length = 181

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 26/84 (30%), Positives = 50/84 (59%), Gaps = 2/84 (2%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LE   WY G+++  +A+ LLR  +  ++L+R+S  S   F +S+++++G   +++  T E
Sbjct: 24  LEACGWYWGSMTGEEAKRLLRWKEVGTFLLRDSSDSAYLFCISVRTARGTTSVRIDYTPE 83

Query: 378 HKYVLGQN--SPPFSSVPEIVHHY 399
             + L  +  SP +  V ++VHHY
Sbjct: 84  GNFRLDSDGSSPEYDCVIKLVHHY 107


>UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=1 Tax=Tribolium castaneum
           RepID=UPI0001757DDC
          Length = 952

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 38/138 (27%), Positives = 68/138 (49%), Gaps = 11/138 (7%)

Query: 285 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
           +PPR + G  +      +  +S L +    A  L+   WY G I R +    L+   + +
Sbjct: 516 IPPRRAVGTAR------ISTNSTLDKEKSNAFSLQEAEWYWGDIKREEVNEKLKETPDGT 569

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRK 403
           +LVR++ T   +++L+L+       +K+   K  KY  G   P  F+SV E+++H+ +  
Sbjct: 570 FLVRDASTKSGEYTLTLRKGGTNKLIKICH-KNGKY--GFTEPYTFNSVVELINHFRNES 626

Query: 404 LPIKGAE-HMSLLYPVAI 420
           L    A   + LLYPV++
Sbjct: 627 LSQYNASLDIKLLYPVSM 644


>UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7QIL2_IXOSC
          Length = 372

 Score = 50.4 bits (119), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 6/90 (6%)

Query: 318 LENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           L  + WY G+I R+  + +L  C ++  +L+R+SET+  D S+SLK+     H ++   +
Sbjct: 270 LRAKEWYFGSIPRSQCDQVLNECAQDGDFLIRDSETNVGDLSVSLKAPLRNKHFRV-HVE 328

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           +  + +GQ    FS + ++V HY  ++ PI
Sbjct: 329 DGVFCIGQRR--FSQLDDLVEHY--KRAPI 354


>UniRef50_Q8BI17 SH2 domain-containing protein 7 n=7 Tax=Euarchontoglires
           RepID=SH2D7_MOUSE
          Length = 458

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 4/90 (4%)

Query: 318 LENQV---WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           L+N V   W+HG I+R   E LLR     S+L+R S+ +   + LS + S    H  +++
Sbjct: 43  LQNGVLPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRAVG-YILSYRGSDRCRHFVINQ 101

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
            +  +Y++  ++   S++ E++ HY   +L
Sbjct: 102 LRNRRYLVSGDTLSHSTLDELLRHYQEVQL 131


>UniRef50_UPI0000E460CB PREDICTED: similar to V-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E460CB
          Length = 305

 Score = 50.1 bits (118), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 25/84 (29%), Positives = 47/84 (55%), Gaps = 3/84 (3%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
            +W+ G I+R++ +NLL   +  ++LVR+S T   D  L +  +    H  ++R K  ++
Sbjct: 16  HLWHFGGITRSETDNLLIQKRPGTFLVRDSRTCPGDSVLCVSENSKVSHYIITR-KADQF 74

Query: 381 VLGQNSPPFSSVPEIVHHYASRKL 404
           V+G     FS++P+I++ Y    L
Sbjct: 75  VIGDQI--FSTLPDILNFYRGHYL 96


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score = 50.1 bits (118), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 2/93 (2%)

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQG 366
           G +  P   LE + W+ G I+R  AE LL +   K   +L+R SE++   FSLS+K  + 
Sbjct: 327 GTFVAPYKSLEAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGEN 386

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
             H ++ +      + G  S P   +P ++ ++
Sbjct: 387 VRHFRVKKVAGGIKLQGSPSSPHKDLPSLIKYH 419


>UniRef50_Q22070 Protein T01E8.3, partially confirmed by transcript evidence n=4
           Tax=Chromadorea RepID=Q22070_CAEEL
          Length = 1350

 Score = 50.1 bits (118), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 33/103 (32%), Positives = 53/103 (51%), Gaps = 8/103 (7%)

Query: 317 PLENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P  NQ W+     +  AE LL L  ++ ++L+R S T  + + LSLK    F H +L R 
Sbjct: 709 PHLNQPWFSATADKEKAEELLSLVPEDGAFLIRTSSTDSSVYVLSLKVDGEFWHYRLKRD 768

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                +   N   F ++ +IV  YA+R+  ++G   +SL +PV
Sbjct: 769 GR---IFVVNQKVFENLNQIVEFYANREF-VRG---ISLRFPV 804


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score = 50.1 bits (118), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 25/82 (30%), Positives = 45/82 (54%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+H  +SR  AENLL   +   +++R S++S  DFS+S++      H K+ R  +  Y L
Sbjct: 58  WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
              +  F S+ ++V +Y +  +
Sbjct: 118 W--TEKFPSLNKLVDYYRTNSI 137


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 1/78 (1%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+HG +SR DAE L++ L  E  +LVR S  S  DF L+L  +   +H ++ R  E  + 
Sbjct: 9   WFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGEDAFF 68

Query: 382 LGQNSPPFSSVPEIVHHY 399
              N   F  +  +++++
Sbjct: 69  SIDNEHIFHGLETLINYH 86



 Score = 42.0 bits (97), Expect = 0.042,   Method: Compositional matrix adjust.
 Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 4/80 (5%)

Query: 323 WYHGAISRTDAENLLRLC--KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           WYHG + R +A  LL+    KE SYLVR S  +   + L++  +    H ++    E+ Y
Sbjct: 284 WYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVNDRSFHFQIK--NENGY 341

Query: 381 VLGQNSPPFSSVPEIVHHYA 400
               + P   S+  ++ +Y+
Sbjct: 342 YFIDDGPLLESLEHVIDYYS 361


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 23/65 (35%), Positives = 37/65 (56%), Gaps = 1/65 (1%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           +E++ W+HG ISR +A  LL + K E  +LVR SE+   ++SLS+       H  + +  
Sbjct: 297 IESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGEYSLSVSHGDSLRHYHIKKEG 356

Query: 377 EHKYV 381
           E  Y+
Sbjct: 357 EEFYI 361


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 36/113 (31%), Positives = 53/113 (46%), Gaps = 7/113 (6%)

Query: 287 PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
           P LSA  P +    +M  +S        A+ L+   W+HG ISR DAE LL   K   +L
Sbjct: 79  PVLSAPQPVADNDAAMNHASK------GAVQLKTMPWFHGRISREDAEKLLTPPKNGRFL 132

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           VR S+    D++L + S  G +     R  E   V   +   F ++ ++V HY
Sbjct: 133 VRESQNYPGDYTLCV-SYDGRVENYRVRRNEKGLVTVDDDEYFDNLIKLVEHY 184


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 5/102 (4%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           PL  Q WYHGAI R +A+ LL+  K+  +LVR S     ++ LS+ S     H  +    
Sbjct: 454 PLAEQDWYHGAIPRIEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVD 511

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                 G     FS++P+++ H+ + K  I     + LL P+
Sbjct: 512 NMYRFEG---TGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 19/125 (15%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E+  P+  + +  W+HG ISR  AE L+R  +   +LVR+S +   +F L+++     MH
Sbjct: 113 EFKLPSEDVRSHAWFHGGISREKAEKLIR--ENGDFLVRDSISKPGNFVLTVRWKGVSMH 170

Query: 370 MKLSRTKEHKYVLGQNSP-----------PFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
             +     +K VL  +SP            F ++P ++  Y     P+  A    + +PV
Sbjct: 171 FVV-----NKVVLKAHSPYASVQYQFEKECFDAIPSLIKFYVGNCRPVSQASGAVIQHPV 225

Query: 419 AIRTL 423
             RTL
Sbjct: 226 N-RTL 229


>UniRef50_B8JL24 Novel protein similar to human and mouse SH2 domain containing 4B
           (SH2D4B) n=2 Tax=Danio rerio RepID=B8JL24_DANRE
          Length = 441

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ISR D+E LL      S+LVR SE     ++LS +++ GF H  +  + ++   L
Sbjct: 344 WFHGIISREDSETLLMNAAVGSFLVRVSERIWG-YTLSYRTASGFKHFLIDASGDYYSFL 402

Query: 383 GQNSPPFSSVPEIV-HHYASRKLPIKG 408
           G +    +++ +++  H  S +   +G
Sbjct: 403 GVDQNRHATLADLIDFHKVSEQKRFQG 429


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 27/78 (34%), Positives = 45/78 (57%), Gaps = 3/78 (3%)

Query: 323 WYHGAISRTDAENL-LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+HG +S  +AE L L   K  S+LVR S++   DF LS+++     H+ + R ++ KY 
Sbjct: 111 WFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMI-RWQDKKYD 169

Query: 382 LGQNSPPFSSVPEIVHHY 399
           +G     F ++ E++ HY
Sbjct: 170 VG-GGESFGTLSELIDHY 186



 Score = 40.8 bits (94), Expect = 0.098,   Method: Compositional matrix adjust.
 Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 3/78 (3%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    +   +
Sbjct: 6   WFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDL 65

Query: 382 LGQNSPPFSSVPEIVHHY 399
            G     F+++PE+V +Y
Sbjct: 66  YG--GEKFATLPELVQYY 81


>UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3 n=43
           Tax=Euteleostomi RepID=BCAR3_HUMAN
          Length = 825

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 31/109 (28%), Positives = 51/109 (46%), Gaps = 12/109 (11%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG I R  +ENL++  ++  +LVR+S +S  +F L+ +      H K++RT  
Sbjct: 149 LRSHAWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206

Query: 376 ------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                    +Y     S  F S+P +V  Y   + PI       +  P+
Sbjct: 207 RLSEAYSRVQYQFEMES--FDSIPGLVRCYVGNRRPISQQSGAIIFQPI 253


>UniRef50_UPI00017F08F6 PREDICTED: similar to SH2D2A protein n=1 Tax=Sus scrofa
           RepID=UPI00017F08F6
          Length = 419

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 1/86 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
           E   W+HG I+R +AE LL    +  YLVR SE++   F L+ +S     H  L++ ++ 
Sbjct: 113 EAPAWFHGFITRREAERLLETEPQGCYLVRFSESAVT-FVLTYRSRTCCRHFLLAQLRDG 171

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKL 404
           ++V+       + + +++ HY +  L
Sbjct: 172 RHVVLGEDSAHARLQDLLLHYTAGPL 197


>UniRef50_UPI0001758844 PREDICTED: similar to vav1 n=1 Tax=Tribolium castaneum
           RepID=UPI0001758844
          Length = 784

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 41/141 (29%), Positives = 66/141 (46%), Gaps = 24/141 (17%)

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAI 328
           G  K C++           R  + N  S   L M  +            L +++W+ G +
Sbjct: 573 GVHKHCIAHS--------GRCGSHNHHSTSDLVMNGADA---------CLRDKLWFVGEM 615

Query: 329 SRTDAENLLRLCKEASYLVR---NSETSKNDFSLSLKSSQGFMHMKLSRTKEH--KYVLG 383
            R+ A+N L   +  ++LVR    SE  K+ ++LSLK++    HMK+  T EH  KY L 
Sbjct: 616 DRSRAQNELERRENGTFLVRIRPQSE-DKDKYALSLKTNDTVKHMKICSTGEHEGKYYLS 674

Query: 384 QNSPPFSSVPEIVHHYASRKL 404
             S  FS++ E+V +Y +  L
Sbjct: 675 L-SKFFSNIEELVLNYQTNSL 694


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score = 49.3 bits (116), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 23/79 (29%), Positives = 44/79 (55%), Gaps = 3/79 (3%)

Query: 323 WYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           +YHG ++R  AEN++ +    +  +LVR S+ S N F LS+  +Q   H ++  ++    
Sbjct: 248 YYHGKLNRVAAENIITIYGSNDGLFLVRFSKGSGN-FILSMCFNQSCFHFQIQCSQAENC 306

Query: 381 VLGQNSPPFSSVPEIVHHY 399
               + P F+S+ +++ HY
Sbjct: 307 YFIDDGPGFTSLGDLIQHY 325


>UniRef50_Q7YWN4 Protein Y87G2A.17, partially confirmed by transcript evidence n=3
           Tax=root RepID=Q7YWN4_CAEEL
          Length = 190

 Score = 49.3 bits (116), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 29/98 (29%), Positives = 56/98 (57%), Gaps = 4/98 (4%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           P +++++    ++R +AE  L       YL+R+    +   +LSL++++G +H+K+    
Sbjct: 90  PSDSEIYMEQNMNRVEAEKRLENRNLGDYLLRSR--GEGSAALSLRATKGVVHIKIEWNG 147

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
           E K+V+G+  P F S+   +  Y    LPI+GA+H+ L
Sbjct: 148 E-KWVIGE-GPLFRSISSAISFYRRHPLPIRGADHLVL 183


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score = 49.3 bits (116), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 26/82 (31%), Positives = 46/82 (56%), Gaps = 2/82 (2%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L+++ +YHG I RT AE  L      S+LVR S+++  + ++SL+      H ++SRT +
Sbjct: 174 LDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEHTISLRCDGKVFHYRISRTDK 233

Query: 378 HKYVLGQNSPPFSSVPEIVHHY 399
             ++       FS+V ++V  Y
Sbjct: 234 GVFIAADR--VFSTVQDLVKFY 253


>UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P596_BRUMA
          Length = 119

 Score = 49.3 bits (116), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 33/106 (31%), Positives = 57/106 (53%), Gaps = 7/106 (6%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           AL L+ Q WYHG + R  AE++LR   E  +LVR S  + N+F LS  ++    H  L  
Sbjct: 9   ALGLDRQPWYHGEMERATAESMLR--NEGDFLVRISPNTANNFVLSGIANSVARHFLLLD 66

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI--KGAEHMSLLYPV 418
             + K  + +    F ++ E++ ++    +PI  +G+E + L+ P+
Sbjct: 67  ENDQK--VRKQQQVFETIVELIEYHRGENVPIISEGSE-LHLIRPI 109


>UniRef50_A9Q0R3 Suppressor of cytokine signaling 1 variant 2 n=1 Tax=Tetraodon
           nigroviridis RepID=A9Q0R3_TETNG
          Length = 196

 Score = 49.3 bits (116), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 31/105 (29%), Positives = 53/105 (50%), Gaps = 9/105 (8%)

Query: 305 SSPLGEW--------TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
           S+ LG W        TD  L LE   +Y G +   DA  +LR     SYL+R+S      
Sbjct: 38  SNRLGTWATEDCDIITDTVLKLERCGFYWGPLGVEDAHRMLRDAPLGSYLIRDSRQKDVF 97

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           F+LS  +  G + ++++ +++ K+ L  N   F ++  ++ +YAS
Sbjct: 98  FTLSYHAKAGPVSVRITYSRQ-KFALAGNDRTFPTLFALLEYYAS 141


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score = 48.9 bits (115), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 36/153 (23%)

Query: 290 SAGNPKSAKPL-----------SMEPSSPLGEWTDPALP-LENQVW----YHGAISRTDA 333
           SAGN +SA+PL           +++P +     +  +LP ++ Q+W    YHG +SR  A
Sbjct: 477 SAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAA 536

Query: 334 ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL------SRTKEHKYVLGQNSP 387
           E+L  L K+  +LVR S TS   + LS        H+ L       RTK+H         
Sbjct: 537 ESL--LVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHV-------- 586

Query: 388 PFSSVPEIVHHYASRKLPI--KGAEHMSLLYPV 418
            F +V  ++ ++    LPI   G+E +SL  PV
Sbjct: 587 -FDNVGHLIRYHMDNSLPIISSGSE-VSLKQPV 617


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score = 48.9 bits (115), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 4/89 (4%)

Query: 317 PLENQVWYHGAISRTD-AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P E +VW+HG +S+ + AE L +      +L+RNS+ +  D+SLS +        ++ + 
Sbjct: 231 PNEGKVWFHGNVSKEEAAETLWKDGDIGGFLIRNSDKNPGDYSLSFRGPNTIQRFRIQK- 289

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           ++ +YV+G     ++S+  IV HY   ++
Sbjct: 290 QQRQYVMG--GRYYNSLDAIVDHYKKEEI 316



 Score = 47.0 bits (110), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 8/81 (9%)

Query: 323 WYHGAISRTDAENLLRLC---KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           WYHG + R  AE  LRL    K  SYLVR SE     + LS    +G  H +++      
Sbjct: 68  WYHGCLDRQSAE--LRLNAADKPGSYLVRESERKPGSYVLSYLGQRGINHFRVTAVCGDF 125

Query: 380 YVLGQNSPPFSSVPEIVHHYA 400
           YV G+    F ++PE++ +Y 
Sbjct: 126 YVGGRQ---FQTLPELIGYYT 143


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score = 48.5 bits (114), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 7/89 (7%)

Query: 318 LENQVWYHGAISRTDAENLL----RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           L  ++WYHG ISR DAE LL    RL    S+LVR+S T+  ++ LSL       H  +S
Sbjct: 4   LSKELWYHGRISRLDAEQLLDNFGRL--SGSFLVRDSLTTTGEYVLSLSFQGKKYHYIIS 61

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
           R  +    + Q+   F S  E++ ++  +
Sbjct: 62  RHPDGSVAI-QDGAKFDSPIELIQYHTKK 89


>UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi RepID=SH2B3_HUMAN
          Length = 575

 Score = 48.5 bits (114), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 26/88 (29%), Positives = 46/88 (52%), Gaps = 5/88 (5%)

Query: 323 WYHGAISRTDAENLLRLC---KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           W+HG ISR  A  L++L        +LVR SET + ++ L+        H++LS T+  +
Sbjct: 364 WFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQ 423

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIK 407
             +      F SV +++HH+    +P++
Sbjct: 424 CRVQHLH--FPSVVDMLHHFQRSPIPLE 449


>UniRef50_Q9NP31 SH2 domain-containing protein 2A n=22 Tax=Theria RepID=SH22A_HUMAN
          Length = 389

 Score = 48.5 bits (114), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 24/83 (28%), Positives = 45/83 (54%), Gaps = 1/83 (1%)

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
            W+HG I+R +AE LL    +  YLVR SE++   F L+ +S     H  L++ ++ ++V
Sbjct: 94  AWFHGFITRREAERLLEPKPQGCYLVRFSESAVT-FVLTYRSRTCCRHFLLAQLRDGRHV 152

Query: 382 LGQNSPPFSSVPEIVHHYASRKL 404
           +       + + +++ HY +  L
Sbjct: 153 VLGEDSAHARLQDLLLHYTAHPL 175


>UniRef50_UPI000186E9A4 SH2 domain-containing protein 4A, putative n=1 Tax=Pediculus
           humanus corporis RepID=UPI000186E9A4
          Length = 472

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 27/92 (29%), Positives = 47/92 (51%), Gaps = 1/92 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ISR +AENLL      S+LVR SE   + +++S + S    H  +  +  H   L
Sbjct: 362 WFHGLISRQEAENLLSDKPVGSFLVRVSEKI-SGYAISYRDSDRCKHYLIDSSNGHYQFL 420

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
           G N     ++ E++  + ++ +   G E + +
Sbjct: 421 GSNQMTHKTLGELITFHETQAITALGGELLRI 452


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 8/115 (6%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  A  L +  WYHGA+ R  AE +++  +E  +LVR+  +  +++ LS +S    +H
Sbjct: 227 ELSLDARELRSHAWYHGALPRQRAEEIVQ--REGDFLVRDCASQPDNYVLSCRSKAAVLH 284

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
             L++      T   +         F +VP+++  Y     PI  A    + +P 
Sbjct: 285 FVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPC 339


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 3/80 (3%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+ G I R  AE +L +   + ++L+R SE++  DFSLS+K      H K+ R    KY 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYAS 401
           L      F+S+ E+V ++ S
Sbjct: 120 LW--VVKFNSLNELVDYHRS 137


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 30/100 (30%), Positives = 57/100 (57%), Gaps = 7/100 (7%)

Query: 323 WYHGAISRTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           W+H  I+  +AENLL L +  + S+L R S+++  DF+LS++ +    H+K+  T ++  
Sbjct: 6   WFHPNITGVEAENLL-LTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64

Query: 381 VLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPV 418
           + G     F+++ E+V +Y     +L  K  + + L YP+
Sbjct: 65  LYG--GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102



 Score = 42.7 bits (99), Expect = 0.025,   Method: Compositional matrix adjust.
 Identities = 31/88 (35%), Positives = 47/88 (53%), Gaps = 13/88 (14%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLK-------SSQG---FMHMK 371
           W+HG +S  +AE LL    K  S+LVR S++   DF LS++       S+ G     H+ 
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           + R +E KY +G     F S+ ++V HY
Sbjct: 172 I-RCQELKYDVG-GGERFDSLTDLVEHY 197


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 2/79 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+   ISR +AENLL       ++VR S+ S  DFS+S++      H K+ R  +  Y L
Sbjct: 73  WFDEKISRHEAENLLMSKGVGCFVVRASQNSHGDFSISVRHEDDVQHFKVMRDSKGSYYL 132

Query: 383 GQNSPPFSSVPEIVHHYAS 401
              +  F S+ ++V +Y +
Sbjct: 133 W--TEKFHSLNKLVDYYKT 149


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 3/80 (3%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+ G I R  AE +L +   + ++L+R SE++  DFSLS+K      H K+ R    KY 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYAS 401
           L      F+S+ E+V ++ S
Sbjct: 120 LW--VVKFNSLNELVDYHRS 137


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score = 48.1 bits (113), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 48/153 (31%), Positives = 73/153 (47%), Gaps = 36/153 (23%)

Query: 290 SAGNPKSAKPL-----------SMEPSSPLGEWTDPALP-LENQVW----YHGAISRTDA 333
           SAGN +SA+PL           +++P +     +  +LP ++ Q+W    YHG +SR  A
Sbjct: 234 SAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAA 293

Query: 334 ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL------SRTKEHKYVLGQNSP 387
           E+L  L K+  +LVR S TS   + LS        H+ L       RTK+H         
Sbjct: 294 ESL--LVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDH--------- 342

Query: 388 PFSSVPEIVHHYASRKLPI--KGAEHMSLLYPV 418
            F +V  ++ ++    LPI   G+E +SL  PV
Sbjct: 343 VFDNVGHLIRYHMDNSLPIISSGSE-VSLKQPV 374


>UniRef50_C3YM24 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3YM24_BRAFL
          Length = 190

 Score = 48.1 bits (113), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 24/85 (28%), Positives = 47/85 (55%), Gaps = 3/85 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L +  WY G++S   A+ LLR     ++L+R+SE     FSLS+K+++G   +++     
Sbjct: 32  LHDSCWYWGSLSGKQAKALLRSQDVGTFLIRDSENCAFLFSLSVKTTRGTTSVRVQYVDG 91

Query: 378 HKYV---LGQNSPPFSSVPEIVHHY 399
           H  +   +  ++P F+ V  ++ +Y
Sbjct: 92  HFKLDSDVNADTPEFNCVLRLIDYY 116


>UniRef50_A9V1A4 Predicted protein (Fragment) n=1 Tax=Monosiga brevicollis
           RepID=A9V1A4_MONBE
          Length = 634

 Score = 48.1 bits (113), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM-HMKLSRTKEHKYV 381
           W+HG +SR +AE+LL      ++L+R S+ S N ++LS+K  + F  H +++      Y 
Sbjct: 511 WFHGLLSRREAEDLLYDSPVGTFLLRVSDRSFN-YALSIKHDKAFFRHYRVTHAASGGYC 569

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKG 408
           +   +  F ++ E+V  +    L + G
Sbjct: 570 VDGAASDFPTLAELVDFFRHENLSVAG 596


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score = 48.1 bits (113), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 2/90 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ISR +AE+LL   +   +LVR SE     + LS +    F H  +  T E  Y+L
Sbjct: 325 WFHGIISRQEAEDLLSEGEPGHFLVRVSERILG-YVLSYRCKDEFKHFLIDAT-EGCYML 382

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
             +   F+S+ E+V  +    + + G E +
Sbjct: 383 LGHQIRFTSLAELVEFHKGEPITMSGGEQL 412


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score = 48.1 bits (113), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 4/102 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WY G I R+ AE +LR   + ++L+R S+T K  ++ S+       H  + +T    Y  
Sbjct: 622 WYVGDIKRSQAEEMLRGTCDGTFLIRESQTQKGSYACSVVVDGDTKHCVVYKTVT-GYGF 680

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHM--SLLYPVAIRT 422
            +    +SS+ ++V HY +  L ++  +H+  +L +PV  R+
Sbjct: 681 AEPYNLYSSLKDLVLHYKNVSL-VQHNDHLNVTLAHPVLARS 721



 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 34/111 (30%), Positives = 59/111 (53%), Gaps = 6/111 (5%)

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHM 370
           TD +  L +  WY G ISR +    LR   + ++LVR++ +  + +++L+L+       +
Sbjct: 351 TDTSSLLNDAEWYWGEISREEVNEKLRDTPDGTFLVRDASSKLEGEYTLTLRKGGNNKLI 410

Query: 371 KLSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVA 419
           K+   +E +Y  G + P  F SV E+++HY    L    A+    LLYPV+
Sbjct: 411 KIYH-REGRY--GFSEPLTFLSVVELINHYRHESLAQYNAKLDTKLLYPVS 458


>UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniota RepID=SH2D3_HUMAN
          Length = 860

 Score = 48.1 bits (113), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 13/95 (13%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG I R  +E L++  +   +L+R+S TS  D+ L+ +     +H K+++   
Sbjct: 215 LRSHAWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVV 272

Query: 376 ------KEHKYVLGQNSPPFSSVPEIV-HHYASRK 403
                    +Y+  Q S  F  VP +V +H  SRK
Sbjct: 273 KAGESYTHIQYLFEQES--FDHVPALVRYHVGSRK 305


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score = 48.1 bits (113), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 26/88 (29%), Positives = 46/88 (52%), Gaps = 5/88 (5%)

Query: 323 WYHGAISRTDAENLLRLC---KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           W+HG ISR  A  L++L        +LVR SET + ++ L+        H++LS T+  +
Sbjct: 371 WFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQ 430

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIK 407
             +      F SV +++HH+    +P++
Sbjct: 431 CRVQHLH--FPSVVDMLHHFQRSPIPLE 456


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score = 48.1 bits (113), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 30/100 (30%), Positives = 57/100 (57%), Gaps = 7/100 (7%)

Query: 323 WYHGAISRTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           W+H  I+  +AENLL L +  + S+L R S+++  DF+LS++ +    H+K+  T ++  
Sbjct: 6   WFHPNITGVEAENLL-LTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64

Query: 381 VLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPV 418
           + G     F+++ E+V +Y     +L  K  + + L YP+
Sbjct: 65  LYG--GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102



 Score = 41.2 bits (95), Expect = 0.066,   Method: Compositional matrix adjust.
 Identities = 27/88 (30%), Positives = 43/88 (48%), Gaps = 12/88 (13%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQG----------FMHMK 371
           W+HG +S  +AE LL    K  S+LVR S++   DF LS+++               H+ 
Sbjct: 112 WFHGHLSGREAEKLLTEKGKNGSFLVRESQSHPGDFVLSVRTGDDKTDSSDSKPKVTHVM 171

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           +    + KY +G     F S+ ++V HY
Sbjct: 172 IRCQHDLKYDVG-GGEKFDSLTDLVEHY 198


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score = 48.1 bits (113), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 17/116 (14%)

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL- 372
           P  PL N+ W+HG +SR + E L  L  +  +LVR S T+K+ + LS   +    H+ L 
Sbjct: 414 PTNPLYNEEWFHGPMSRKEGEPL--LSNDGDFLVRESTTAKDQYVLSGMQNGTPKHLLLV 471

Query: 373 -----SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                 RTK+ +         F SV  +++++ + +LPI  A     L    +R  
Sbjct: 472 DPQGKVRTKDKE---------FDSVSHLINYHRNNRLPIISAGSAVHLKTPVVRKF 518


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score = 48.1 bits (113), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 37/142 (26%), Positives = 64/142 (45%), Gaps = 24/142 (16%)

Query: 277 PGREEKGRLPPRLSAGN-----PKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
           P R   GR   RLS+ +     P +   +SME        TD    L+ + W+HG + R+
Sbjct: 279 PPRHVSGRGGDRLSSSSNFDMCPSTGDNISME--------TDIGQTLKKEFWFHGTLGRS 330

Query: 332 DAENLLR---LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP 388
           +A NL+          +LVR SET   +F L+        H++++   +     GQ    
Sbjct: 331 EATNLVLHDGARGHGLFLVRQSETRTGEFVLTFNFQGRAKHLRMTINDQ-----GQCRVQ 385

Query: 389 ---FSSVPEIVHHYASRKLPIK 407
              F S+ E++ H+  + +P++
Sbjct: 386 HFWFQSIYEMLEHFRQQPIPLE 407


>UniRef50_B6IKC5 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=B6IKC5_CAEBR
          Length = 208

 Score = 47.8 bits (112), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 27/111 (24%), Positives = 54/111 (48%), Gaps = 12/111 (10%)

Query: 319 ENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSL------KSSQGFMHM 370
           ENQ+W+   ++R +AE+ L++  C E S+L+  +   + +++  L      K+S G +  
Sbjct: 90  ENQLWFFKGLTRYNAEDKLKIRGCIEGSFLITTNPNQRKEYAFRLTLFYVSKTSSGIVRP 149

Query: 371 K----LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           K     +  + HKY + +    F ++  +V H    K+ I G   + +  P
Sbjct: 150 KTIVWFNNERPHKYGIREVKQKFENLTSLVRHLIDNKVQIDGVTLVDIFQP 200


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score = 47.8 bits (112), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 9/112 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L++  WYHG + R   E LL   ++  +LVR+S ++  D+ L+     G MH K+ R   
Sbjct: 19  LKSHAWYHGPLGREAGEALLE--RDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKIIRVVL 76

Query: 378 H------KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                  + +       F +VP ++  +   + PI  A    + +P+  RTL
Sbjct: 77  RPKQGYSRELFQFEEDRFDNVPALIRFHVGSRRPISQASSAVIFHPIT-RTL 127


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score = 47.8 bits (112), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 26/63 (41%), Positives = 33/63 (52%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 242 YVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 301

Query: 371 KLS 373
           ++S
Sbjct: 302 RIS 304


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score = 47.4 bits (111), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 4/91 (4%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +E+Q W+ G ++R  A + L   +    S+LVR SE+    + LS+++ +   H K+ +T
Sbjct: 129 VESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQT 188

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
            +  YV       FSS+ E++ HY S  L I
Sbjct: 189 GDQFYV--DALFKFSSIVEVIEHYQSHPLSI 217


>UniRef50_B3RJ03 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RJ03_TRIAD
          Length = 235

 Score = 47.4 bits (111), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 23/82 (28%), Positives = 47/82 (57%), Gaps = 5/82 (6%)

Query: 323 WYHGAISRTDAENLLRLCKEAS----YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
           +Y+G + R DAE LL L +       +L+R SE+ K +F+LS+K +   +H +L   ++ 
Sbjct: 138 YYYGEMKRADAEKLL-LSESVDGCNLFLIRKSESYKGEFALSVKENDDILHFRLPELQQD 196

Query: 379 KYVLGQNSPPFSSVPEIVHHYA 400
             ++ +    F S+ ++V +++
Sbjct: 197 SLIIARKYIEFISLDDLVQYFS 218


>UniRef50_Q7JVF1 Suppressor of cytokine signaling at 44A n=12 Tax=Drosophila
           RepID=Q7JVF1_DROME
          Length = 342

 Score = 47.4 bits (111), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 24/53 (45%), Positives = 33/53 (62%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           NQVWY G ISR D++  L      S+LVR+SETS + F+LS +     +H +L
Sbjct: 186 NQVWYWGEISRRDSQRQLSDKPTGSFLVRDSETSGSQFTLSFRIVNVTLHYRL 238


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score = 47.4 bits (111), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 31/100 (31%), Positives = 55/100 (55%), Gaps = 7/100 (7%)

Query: 323 WYHGAISRTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           W+H  IS  +AE LL L +    S+L R S+++  DF+LS++ +    H+K+  T ++  
Sbjct: 4   WFHPNISGIEAEKLL-LTRGVHGSFLARPSKSNPGDFTLSVRRNDEVTHIKIQNTGDYYD 62

Query: 381 VLGQNSPPFSSVPEIVHHYASRK--LPIKGAEHMSLLYPV 418
           + G     F+  PE+V +Y  ++  L  K +  + L YP+
Sbjct: 63  LYG--GEKFARKPELVQYYTEQQGLLREKNSNVIELKYPL 100


>UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S6Q5_TETNG
          Length = 803

 Score = 47.4 bits (111), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 18/112 (16%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L +  WYHGAI R  AENL++  ++  +L+R+S +S   + L+ +      H K+     
Sbjct: 31  LRSHAWYHGAIPRQVAENLVQ--RDGDFLIRDSLSSPGSYVLTSQWRNTAQHFKI----- 83

Query: 378 HKYVLGQNSP-----------PFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +K V+  N              F SVP ++  Y   + P+       +  P+
Sbjct: 84  NKKVVALNEAYTRVEFRLEREGFDSVPALIRFYVGNRKPVSQVVGAIIFQPI 135


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 7/101 (6%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           +E + WYHG ISR +A  LL+  K   +LVR S   K  ++L++K  +G  H  +   +E
Sbjct: 512 VEEEPWYHGEISRQEATGLLK--KMGDFLVRYS-ADKEHYTLTVK-MEGIKHFIIQHNEE 567

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                G    P+ S+P ++ H+   +LP+       L  PV
Sbjct: 568 GFRFEG---DPYPSIPMLIDHHFKNRLPVTRKSQAILRQPV 605


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 17/104 (16%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL----- 372
           L+++ W+HG ++R +AE L  L  +  +LVR S T+K  F LS      + H+ L     
Sbjct: 395 LQSKPWFHGHVTRKEAEQL--LSHDGDFLVRESTTTKGQFVLSGVQDGQYKHLLLVDPNG 452

Query: 373 -SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
             RTK+ +         F SV  ++  +    LPI  +  + LL
Sbjct: 453 VVRTKDRQ---------FDSVSHLISFHRDNTLPIVSSGSVLLL 487


>UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, partial n=1 Tax=Tribolium
           castaneum RepID=UPI000175898D
          Length = 876

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 27/106 (25%), Positives = 54/106 (50%), Gaps = 8/106 (7%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHGAI R+ AE+++R  +E  +LVR+  +   ++ L+ ++    +H  +++   
Sbjct: 171 LRSHAWYHGAIPRSRAEDIVR--EEGGFLVRDCTSQPGNYVLTCRTKTQPLHFVINKIIL 228

Query: 376 ---KEHKYVLGQ-NSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
                +++V  Q     F +VP+++  Y     PI  A    + +P
Sbjct: 229 QPDTVYEHVQFQFEEDAFDTVPDLITFYVGSGKPITAASGARIQFP 274


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score = 47.0 bits (110), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 3/86 (3%)

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY G ISR  AE +L +     ++L+R SE+S  +FS+S+       H K+ R    KY 
Sbjct: 60  WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIK 407
           L +    F+S+ E+V  Y +  +  K
Sbjct: 120 LWEEK--FNSLNELVDFYRTTTIAKK 143


>UniRef50_A8P112 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P112_BRUMA
          Length = 931

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/84 (33%), Positives = 49/84 (58%), Gaps = 2/84 (2%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           Q WY G + R D+E LLR   + ++LVR S +++  + +S+  +    H K+ ++ E +Y
Sbjct: 772 QQWYRGPMKRWDSEELLRGTPDGTFLVRFS-SAQQKYVISISFNGDVKHTKVEQSPEGRY 830

Query: 381 VLGQNSPPFSSVPEIVHHYASRKL 404
            L + S  FSSV E++++Y    L
Sbjct: 831 YLDE-STMFSSVVELINYYRENNL 853


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/118 (25%), Positives = 53/118 (44%), Gaps = 8/118 (6%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  A  L +  WYHG + R  AE +++  +E  +LVR+  +  +++ LS +S    +H
Sbjct: 228 ELSLDARELRSHAWYHGPLPRQRAEEIVQ--REGDFLVRDCASQPDNYVLSCRSKLAVLH 285

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
             L++      T   +         F +VP+++  Y     PI  A    + YP   R
Sbjct: 286 FVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISAASGALIQYPCNRR 343


>UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Fragment)
           n=8 Tax=Euteleostomi RepID=Q5T4P3_HUMAN
          Length = 206

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/110 (30%), Positives = 61/110 (55%), Gaps = 6/110 (5%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMK 371
           D ++ L++  WY G ISR +  + LR   + ++LVR++ T  + D++L+L+       +K
Sbjct: 55  DSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIK 114

Query: 372 LSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVA 419
           +   ++ KY  G + P  F+SV E+++HY    L        + L+YPV+
Sbjct: 115 IYH-RDGKY--GFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVS 161


>UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio RepID=A2BDR6_DANRE
          Length = 635

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/114 (28%), Positives = 58/114 (50%), Gaps = 13/114 (11%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG I    +E+L++  +E  +L+R+S +S  D+ L+ + +Q  +H  +++   
Sbjct: 45  LSSHGWYHGRIPWEVSESLVQ--QEGDFLIRDSLSSIGDYVLTCRWNQKALHFLITKVLL 102

Query: 376 ------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                    +Y+L + +  F SVP +VH Y   K P+       +  PV  RTL
Sbjct: 103 RSYDTYTRVQYILEEET--FYSVPALVHSYVGNKRPLTKKSAAYIYSPVN-RTL 153


>UniRef50_D2HL11 Putative uncharacterized protein (Fragment) n=4 Tax=Laurasiatheria
           RepID=D2HL11_AILME
          Length = 429

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 20/77 (25%), Positives = 42/77 (54%), Gaps = 1/77 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG I+R   E LL      S+L+R S+ +   + LS + S    H  +++ +  +Y++
Sbjct: 43  WFHGFITRKQTEQLLGDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLQNRRYLV 101

Query: 383 GQNSPPFSSVPEIVHHY 399
             ++   +++ ++V HY
Sbjct: 102 SGDTHSHTTLADLVRHY 118


>UniRef50_UPI00017B2438 UPI00017B2438 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B2438
          Length = 511

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 29/99 (29%), Positives = 54/99 (54%), Gaps = 7/99 (7%)

Query: 322 VWYHGAISRTDAENLLR-LCKEASYLVRNS--ETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            WY G +SR  AE  L+   K+ +YLVR+S  + +   F+L +   +   ++++ R + +
Sbjct: 399 CWYVGQVSRGQAEGCLKYFHKDGAYLVRDSVRQLAGQPFTLMVFYQEKVYNIQI-RQQNN 457

Query: 379 KYVLGQN---SPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
           +++LG       PF SV +I++HY+   L +  A+  S 
Sbjct: 458 QFLLGTGLKVQEPFPSVRDIIYHYSQFPLLLIDAKKRSF 496


>UniRef50_UPI0000D56C32 PREDICTED: similar to suppressor of cytokine signaling 2 n=1
           Tax=Tribolium castaneum RepID=UPI0000D56C32
          Length = 252

 Score = 46.6 bits (109), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 5/86 (5%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV- 381
           WY+  ++   ++ LL+  +  ++LVRNS   +  FSLS+++ +G   ++L  T  H  + 
Sbjct: 95  WYYEGLTFDRSDELLKDTRVGTFLVRNSSDPRFLFSLSVQTDRGPKSVRLFYTNGHFRLD 154

Query: 382 ----LGQNSPPFSSVPEIVHHYASRK 403
               L  + P F  V E+V HY  R+
Sbjct: 155 AQPHLQASMPLFPGVIELVQHYVRRR 180


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 18/108 (16%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL----- 372
           L  + W+HG +SR +AE LL+L     +LVR S T+   + L+   S    H+ L     
Sbjct: 342 LRGEPWFHGKLSRREAEALLQL--NGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEG 399

Query: 373 -SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPV 418
             RTK+H+         F SV  ++ ++    LPI  A   + L  PV
Sbjct: 400 VVRTKDHR---------FESVSHLISYHVDNHLPIISAGSELCLQQPV 438


>UniRef50_A9V255 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V255_MONBE
          Length = 192

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 27/99 (27%), Positives = 50/99 (50%), Gaps = 3/99 (3%)

Query: 323 WYHGAISRTDA-ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           +YHG I+R +A + LL+   + S+L+R S T    ++LSL   +   H+++  T +  Y 
Sbjct: 4   YYHGRITREEAVDRLLKEGVDGSFLLRMSTTQDGVYTLSLMQGESVRHIRIVNTIDGGYA 63

Query: 382 LGQNSPPFSSVPEIVHHYASRKL--PIKGAEHMSLLYPV 418
           +    P   SV ++V       L      ++ ++L YP+
Sbjct: 64  ISAGDPGVDSVWQLVETQMHNTLTSAYDRSDQVALRYPL 102


>UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q8AVM4_XENLA
          Length = 676

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT---- 375
           +  WYHG I R  +E+L++  +   +L+R+S TS  D+ L+ +     +H K+++     
Sbjct: 36  SHAWYHGRIPREVSESLVQ--RNGDFLIRDSLTSLGDYVLTCRWKNESLHFKINKVMVKT 93

Query: 376 ----KEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
                  +Y+  Q S  F ++P +V +Y   + P+
Sbjct: 94  SDSYTRIQYLFEQES--FDNIPALVRYYVGSRRPV 126


>UniRef50_A9URA8 Predicted protein n=3 Tax=Monosiga brevicollis RepID=A9URA8_MONBE
          Length = 1786

 Score = 46.2 bits (108), Expect = 0.002,   Method: Composition-based stats.
 Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 8/117 (6%)

Query: 293  NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
            NP      +   S P+G     + PL    WY   ++R D  + L      ++LVR+S+ 
Sbjct: 1598 NPSFGTTYATPGSLPVGFVPGVSNPLYE--WYQPEMTRQDCSSELATAAPGTFLVRDSKA 1655

Query: 353  SKNDFSLSLKSSQGFMHMKLSRTKEHKYVL------GQNSPPFSSVPEIVHHYASRK 403
            +     L +K+    +H K+  T +  Y L          P F  +P +++HY SR+
Sbjct: 1656 TPGWHILGVKTENDVLHEKIRATDDGMYQLLPSSGPAHEQPRFGDLPSLINHYGSRQ 1712


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 11/91 (12%)

Query: 318 LENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL--- 372
           LE+  WY G + R +AE+ L+L      S+LVR SE+  +++SLS++      H ++   
Sbjct: 217 LESNEWYFGELKRIEAEHYLQLPGNDHGSFLVRISESQSSEYSLSVREENTVKHYRIRSR 276

Query: 373 -SRTK---EHKYVLGQNSPPFSSVPEIVHHY 399
            SRT    +  Y+  Q   PF ++ ++V+HY
Sbjct: 277 YSRTDPTLKRFYISRQ--LPFVNIQQLVNHY 305


>UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepID=Q05DQ0_HUMAN
          Length = 283

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 35/116 (30%), Positives = 63/116 (54%), Gaps = 18/116 (15%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMK 371
           D ++ L++  WY G ISR +  + LR   + ++LVR++ T  + D++L+L+       +K
Sbjct: 55  DSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIK 114

Query: 372 LSRTKEHKYVLGQNSP-PFSSVPEIVHHYASR-------KLPIKGAEHMSLLYPVA 419
           +   ++ KY  G + P  F+SV E+++HY          KL +K      L+YPV+
Sbjct: 115 IYH-RDGKY--GFSDPLTFNSVVELINHYHHESLAQYNPKLDVK------LMYPVS 161


>UniRef50_Q1LWW1 Novel protein similar to vertebrate phospholipase C, gamma 2
           (Phosphatidylinositol-specific) (PLCG2) (Fragment) n=2
           Tax=Danio rerio RepID=Q1LWW1_DANRE
          Length = 270

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 32/104 (30%), Positives = 59/104 (56%), Gaps = 8/104 (7%)

Query: 317 PLENQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           PL +  W++  +SR +AE+ LLR+ ++ ++L+R     ++ F+LS++S     H K+ R 
Sbjct: 165 PLHHMGWFYSNMSRAEAEDCLLRIPRDGAFLIR-KRNERDTFALSIRSEGDIKHYKIFR- 222

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           K  KYVL  ++  F S+ ++V  + +++     A    L YPV 
Sbjct: 223 KSSKYVLA-DAYEFFSLEDMVSCFRNQQF----AGKTKLRYPVT 261


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 18/108 (16%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS---- 373
           L+ + WY G +SR +AE LL   K+  +LVR S T+   F L+   +    H+ L     
Sbjct: 494 LQAETWYQGEMSRKEAEGLLE--KDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEG 551

Query: 374 --RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPV 418
             RTK+           F S+  +++H+    LPI  A   + L  PV
Sbjct: 552 TIRTKDRV---------FDSISHLINHHLESSLPIVSAGSELCLQQPV 590


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 51/172 (29%), Positives = 80/172 (46%), Gaps = 21/172 (12%)

Query: 236 DSSPSLPDGDRDISGPASPLPEP--SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGN 293
           D  P+LP      + P SP P+   +L D +A+  G     LS  R +  RL      G 
Sbjct: 39  DPVPTLP------AEPCSPFPQLFLALYDFTARCGGE----LSVRRGD--RLCALEEGGG 86

Query: 294 PKSAKPLSMEPSSPLGEWTDPALP----LENQVWYHGAISRTDAENLLRL--CKEASYLV 347
              A+ LS +PS+ L   T  A      L +Q WY   +SRT A+ LL     +  ++L+
Sbjct: 87  YIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLI 146

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           R SE+S   +SLS+++     H ++S   +    L Q    F  + E++ +Y
Sbjct: 147 RPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYL-QKGRLFPGLEELLTYY 197


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/96 (27%), Positives = 55/96 (57%), Gaps = 11/96 (11%)

Query: 320 NQVWYHGAISRTDAEN-LLRLCKEASYLVRNSET---SKNDFSLSLKSSQGFMHMKLSRT 375
           N+ WYH +++RTDAEN L+R+ ++ ++LVR   +   S   F++S ++     H ++ + 
Sbjct: 676 NKEWYHDSMTRTDAENVLMRIPRDGAFLVRKCRSDDPSVTSFAISFRADGKIKHCRI-KQ 734

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHY----ASRKLPIK 407
           +   +V+G  +  F ++ +++  Y      RK+ +K
Sbjct: 735 ESRLFVIG--NATFETLCDVISFYEKNPLYRKMKLK 768



 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 27/92 (29%), Positives = 47/92 (51%), Gaps = 6/92 (6%)

Query: 323 WYHGAISRTDAENLLRLC--KEASYLVRNSETSKNDFSLSLKSSQGFMHMKL--SRTKEH 378
           WYHG + R +A+ LLR    K+ S++VR S T   + +LS        H ++   +   H
Sbjct: 568 WYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCTLSFMYHGRVTHCRIHSQQNNGH 627

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
            Y    ++  F S+  +V HY  ++ P++ A+
Sbjct: 628 TYFYLVHALLFDSLYSLVWHY--QRYPLRNAK 657


>UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2RUZ0_DANRE
          Length = 906

 Score = 46.2 bits (108), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 7/108 (6%)

Query: 317 PLENQVWYHGAISRTDAENLLR---LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           PL    W+HG +SR  A  L+    +     +LVR SET + ++ L+        H++LS
Sbjct: 709 PLSECQWFHGTLSRLKAAQLVLAGGMASHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS 768

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK--GAEHMSLLYPVA 419
             ++ +  +      F S+ +++ H+    +P++  GA  ++L+  V 
Sbjct: 769 LNEDGQCRV--QHLWFQSIFDMLEHFRVHPIPLESGGASDVTLISFVG 814


>UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE
          Length = 249

 Score = 46.2 bits (108), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WY    SR  A++ L      ++++R S++S  DFS+S++      H K+ R ++ +Y L
Sbjct: 58  WYKENTSRQSAQDELMCQPIGAFIIRGSQSSPGDFSISVRHENDVQHFKVMRDRQGRYYL 117

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
              S  F+S+ ++V +Y    +
Sbjct: 118 W--SEMFTSLNKLVDYYTHNSI 137


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score = 46.2 bits (108), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 29/99 (29%), Positives = 51/99 (51%), Gaps = 5/99 (5%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+H  IS  DAE++L+      S+L R S  ++ DFSLS++  +   H+++  T +   +
Sbjct: 4   WFHRDISGLDAESVLKSRGVHGSFLARPSRKNQGDFSLSVRVGELVTHIRIQNTGDFYDL 63

Query: 382 LGQNSPPFSSVPEIVHHYASRK--LPIKGAEHMSLLYPV 418
            G     F+++ E+V +Y +    L  K    + L YP 
Sbjct: 64  YG--GEKFATLSELVEYYTAENGILQDKDGTIIELKYPF 100


>UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=SH2B1_HUMAN
          Length = 756

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 25/94 (26%), Positives = 46/94 (48%), Gaps = 5/94 (5%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEAS---YLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           PL    W+HG +SR  A  L+      S   +LVR SET + ++ L+        H++LS
Sbjct: 521 PLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS 580

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
             +E +  +      F S+ +++ H+    +P++
Sbjct: 581 LNEEGQCRVQHLW--FQSIFDMLEHFRVHPIPLE 612


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKS----- 363
           +  PA  ++ + WY G + R DAE LL     +   +LVR SET+K  +SLS++      
Sbjct: 146 YVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIR 205

Query: 364 SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
                H K+ +     Y +   +  F ++ ++V HY 
Sbjct: 206 GDNVKHYKIRKLDNGGYYITTRA-QFDTLQKLVKHYT 241


>UniRef50_A9UZF3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZF3_MONBE
          Length = 411

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 3/79 (3%)

Query: 326 GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQN 385
            A+SRTDA++ LR   E ++++R+S +    F LS+       H K+ R     Y +G  
Sbjct: 69  AAVSRTDADSRLRGTPEGTFIIRDS-SKGGSFVLSVSEGGKVSHYKIDRRSPCVYEIGDE 127

Query: 386 SPPFSSVPEIVHHYASRKL 404
           S  F+++PEI+  Y    L
Sbjct: 128 S--FANLPEIIEFYKRHML 144


>UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Euteleostomi
           RepID=A2AK86_MOUSE
          Length = 236

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 13/95 (13%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG I R  +E L++  +   +L+R+S TS  D+ L+ +     +H K+++   
Sbjct: 57  LRSHAWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWHNQALHFKINKVVV 114

Query: 376 ------KEHKYVLGQNSPPFSSVPEIV-HHYASRK 403
                    +Y+  Q S  F  VP +V +H  SRK
Sbjct: 115 KAGESYTHIRYLFEQES--FDHVPALVRYHVGSRK 147


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 11/101 (10%)

Query: 323 WYHGAI--SRTDAENLLR---LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           W+HG +   R  AE+LL+      + ++LVR S+T   DFSLS        H ++   +E
Sbjct: 560 WFHGKLEGGRRKAEDLLKEYSYLGDGTFLVRESDTFVGDFSLSFWRKDSVNHCRIRSKQE 619

Query: 378 H---KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
               KY L  N   F S+  ++ HY  +K P++  +   +L
Sbjct: 620 RGQTKYYLIDN-LAFDSLYSLITHY--QKYPLRSQDFQQIL 657


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 28/110 (25%), Positives = 51/110 (46%), Gaps = 18/110 (16%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           +  WYHGAI R  AENL++  ++  +L+R+S +S  ++ L+ +      H K++     K
Sbjct: 155 SHAWYHGAIPRQVAENLVQ--RDGDFLIRDSLSSPGNYVLTCQWKNSPQHFKIN-----K 207

Query: 380 YVLGQNSP-----------PFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            V+  N              F S+P +V +Y   + P+       +  P+
Sbjct: 208 RVVAMNEAYSRVQYLFEKEGFDSIPALVRYYVGNREPVSEVIGAIIFQPI 257


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score = 45.8 bits (107), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 25/79 (31%), Positives = 44/79 (55%), Gaps = 3/79 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKS-SQGFMHMKLSRTKEHKYV 381
           WYH  ISR  AE LL+   + S+LVR S +S  ++S++L+   +   H +++      +V
Sbjct: 128 WYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGEYSITLRCDGKARTHYRINHDARGYFV 187

Query: 382 LGQNSPPFSSVPEIVHHYA 400
                  F++V ++V H+A
Sbjct: 188 AA--GKFFATVEQLVAHHA 204


>UniRef50_A9V8Y4 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V8Y4_MONBE
          Length = 1794

 Score = 45.4 bits (106), Expect = 0.004,   Method: Composition-based stats.
 Identities = 24/85 (28%), Positives = 46/85 (54%), Gaps = 4/85 (4%)

Query: 323  WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
            WY   ++R DA   L    + +++VR+S+ +     L +K+    +H K+ R +E  Y L
Sbjct: 1627 WYAPDLTRQDAAGELTDRPDGAFVVRDSKATPGWHILGVKAGNQVLHEKIRRDEEGLYEL 1686

Query: 383  ----GQNSPPFSSVPEIVHHYASRK 403
                 +  P F S+P+++H+Y S++
Sbjct: 1687 VPSNNEPQPAFYSLPDLIHYYGSQR 1711


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 23/78 (29%), Positives = 45/78 (57%), Gaps = 1/78 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYHGA+SR   E+LLR     S+LVR SE++    S++++      H ++S+     + +
Sbjct: 241 WYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 300

Query: 383 GQNSPPFSSVPEIVHHYA 400
            + +  F +V +++ H++
Sbjct: 301 TE-AHRFPTVVQLIEHHS 317


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 3/102 (2%)

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQG 366
           G +  PA   + Q W+ G ++R  A++ L      E ++L+R SE     + LS++S   
Sbjct: 55  GNYLAPAESGQTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQ 114

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG 408
             H K+ +T ++++ + +    FSS+ E+V +Y    L   G
Sbjct: 115 VKHYKVLQTDQNRFYV-EPGRRFSSLAELVDYYQKTSLNNAG 155


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 23/78 (29%), Positives = 45/78 (57%), Gaps = 1/78 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYHGA+SR   E+LLR     S+LVR SE++    S++++      H ++S+     + +
Sbjct: 78  WYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 137

Query: 383 GQNSPPFSSVPEIVHHYA 400
            + +  F +V +++ H++
Sbjct: 138 TE-AHRFPTVVQLIEHHS 154


>UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Takifugu rubripes
           RepID=UPI00016E9884
          Length = 843

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 28/92 (30%), Positives = 43/92 (46%), Gaps = 8/92 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L++  WYHG +    AE+L+       +L+R+S ++  DF L+    Q  +H  + RT  
Sbjct: 193 LKSHAWYHGPVPWEVAESLV--VNHGEFLIRDSRSNHGDFVLTCHWQQKTLHFLIRRTVL 250

Query: 376 -KEHKYVLGQNS---PPFSSVPEIVHHYASRK 403
                Y   Q S     F S+P +VH Y   K
Sbjct: 251 QSSETYTRVQYSLEEEAFDSLPALVHFYVGSK 282


>UniRef50_Q4SKC0 Chromosome 13 SCAF14566, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4SKC0_TETNG
          Length = 1249

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 29/104 (27%), Positives = 58/104 (55%), Gaps = 7/104 (6%)

Query: 317 PLENQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P  N+ W++  +SR  AE+ L+R+ ++ ++L+R  E   + F+++ K      H ++ + 
Sbjct: 626 PHLNEGWFYSDLSRGQAEDYLMRIPRDGAFLIRQREGEPDSFAITFKGDGKVKHCRIQK- 684

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           +  +Y+LG  +  F S+ E+V ++ +R L  K    + L YPV 
Sbjct: 685 EGTRYLLG-TTTYFESLVELVSYFRNRPLYRK----IKLRYPVT 723


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 49/180 (27%), Positives = 78/180 (43%), Gaps = 20/180 (11%)

Query: 238 SPSLPDGDRDISGPASPLPE------PSLEDSSAQFEGPEKSCLS-PGREEKGRLPPRLS 290
           SP  P           PLP       P+    SA+  G  K+  S PG    G +P    
Sbjct: 326 SPRCPSTSSSAGADVEPLPTTPDFTAPAGHRGSAELGGQSKTRSSRPGSGFLGLIP---- 381

Query: 291 AGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK---EASYLV 347
             + + A P S+ P  P  + TD  L   +  W+HG ISR  A +L++         +LV
Sbjct: 382 --SLRPADPASLPPPEPAVQKTDHFL--FSYPWFHGPISRVKAAHLVQSSGPEGHGVFLV 437

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           R SET + D+ L+        H++LS T+  +  +      F SV +++ H+    +P++
Sbjct: 438 RQSETRRGDYVLTFNYQGKAKHLRLSLTEWGQCRVQHLR--FPSVMDMLSHFRLYPIPLE 495


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 25/104 (24%), Positives = 59/104 (56%), Gaps = 11/104 (10%)

Query: 321 QVWYHGAISRTDAENLLRLCK-EASYLVR----NSETSKNDFSLSLKSSQGFMHMKLSRT 375
           + W+H  +SR++AE +L+  + + ++L+R    N++  + ++++S ++     H ++   
Sbjct: 653 KAWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQNTKAGQKNYAISFRAEGKVKHCRIEVD 712

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYAS----RKLPIKGAEHMSLL 415
           +  +Y +G  S  F S+ E+V +Y +    R++ +K A +  LL
Sbjct: 713 ESGQYCIG--SAIFDSLTELVQYYEANPLYRRMRLKYAINEDLL 754



 Score = 43.9 bits (102), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 10/87 (11%)

Query: 323 WYHGAIS--RTDAENLLRLCKEA--SYLVRNSETSKNDFSLSL----KSSQGFMHMKLSR 374
           W+HG ++  R  AE LL   K+   ++LVR S T   D+SLS     K +   +H K   
Sbjct: 544 WFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTTFTGDYSLSFVRDGKYNHCRIHTKSEG 603

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYAS 401
            K   Y++ Q    F S+ E++ HY S
Sbjct: 604 GKTRFYLIDQ--TLFDSIYELIMHYKS 628


>UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9Y7_MONBE
          Length = 947

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 3/79 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE--HKY 380
           W+HG I+R +AE+LL       +L R SET +  ++LS+++     H  +  T+E   +Y
Sbjct: 839 WFHGVITRREAEDLLAPKPIGCFLTRISET-RLGYTLSVRTRHACKHFVIEETRESPSRY 897

Query: 381 VLGQNSPPFSSVPEIVHHY 399
           +L      F ++  ++ HY
Sbjct: 898 MLQGRDVYFDTLERLIEHY 916


>UniRef50_Q56A36 Hematopoietic SH2 domain-containing protein homolog n=3 Tax=Danio
           rerio RepID=HSH2D_DANRE
          Length = 365

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 26/92 (28%), Positives = 49/92 (53%), Gaps = 6/92 (6%)

Query: 318 LENQV---WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           LEN V   W+HG ISR  AE +L +CK A Y +     S+  ++LS ++     H  ++ 
Sbjct: 26  LENGVVPEWFHGIISRKAAEEML-MCKPAGYFLIRVSESRVGYTLSYRAEDRCRHFMINV 84

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
             ++++++      + S+ ++V  +  R+ PI
Sbjct: 85  LPDNQFMIVGEKTVYCSLHDLVAFH--RRCPI 114


>UniRef50_C3XWJ1 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3XWJ1_BRAFL
          Length = 181

 Score = 45.1 bits (105), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 5/87 (5%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LE   WY  ++SR +A  LL   +E ++LVR+S    + FSLSL++++G +  ++  T+ 
Sbjct: 22  LEASGWYWASVSRYEAAALLSGKEEGTFLVRDSADPGHLFSLSLQTARGVLSARIVYTEH 81

Query: 378 HKYVLGQ-----NSPPFSSVPEIVHHY 399
             + L       +SP F  V +++  Y
Sbjct: 82  GTFRLDSIGKPCDSPHFDCVVKLLDFY 108


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score = 45.1 bits (105), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 23/82 (28%), Positives = 42/82 (51%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+    SR+ AE LLR      +++R  ++S  +FS+S++      H K+ R    +Y L
Sbjct: 58  WFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFKVMRDSRGQYFL 117

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
              S  F+S+ ++V  Y +  +
Sbjct: 118 W--SEKFTSLNKLVDFYRTSSI 137


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 45.1 bits (105), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 25/81 (30%), Positives = 41/81 (50%), Gaps = 1/81 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            NQ W+H  ISR + E LLR   + ++LVR S     DF+L +       H ++ +T   
Sbjct: 144 NNQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSGG 203

Query: 379 KYVLGQNSPPFSSVPEIVHHY 399
           +    +    FS++ ++V HY
Sbjct: 204 QLTCDK-EEYFSNLTQLVSHY 223


>UniRef50_D1G5I2 Cytokine signaling 2 n=1 Tax=Eriocheir sinensis RepID=D1G5I2_ERISI
          Length = 357

 Score = 45.1 bits (105), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 5/89 (5%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG----FMHMKLS 373
           LE   WYHG+++   A  LLR     ++L+R+S + +  +SLS+ ++ G     +H    
Sbjct: 200 LEESGWYHGSLTWQQAATLLRDTPVGTFLLRDSASPQCLYSLSVNTTNGPTSVRIHYSCG 259

Query: 374 RTKEHKYVLGQ-NSPPFSSVPEIVHHYAS 401
           R +       Q ++P F+ V E+V HY +
Sbjct: 260 RFRLDCTGHSQRHTPEFTGVVELVEHYVN 288


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 9/106 (8%)

Query: 319 ENQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           E++ WYH  +SR+ AEN L+R+ ++ ++LVR      N F++S ++     H ++ +  +
Sbjct: 743 ESKEWYHANLSRSQAENMLMRVPRDGAFLVRK-RAEPNSFAISFRAEGKIKHCRVQQEGQ 801

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
              VLG  +  F S+ +++ +Y    L  K    M L YP+   TL
Sbjct: 802 -TVVLG--TSEFDSLVDLISYYEKHPLYRK----MKLRYPINEDTL 840


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 2/78 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG I R +AENLL+  ++  +LVR S     D++L +  ++   H ++ +  E+K  +
Sbjct: 378 WFHGRIKREEAENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRI-KYAENKLTI 436

Query: 383 GQNSPPFSSVPEIVHHYA 400
             +   F ++ ++V HY 
Sbjct: 437 -DDDEYFDNLGQLVEHYT 453


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 31/101 (30%), Positives = 49/101 (48%), Gaps = 9/101 (8%)

Query: 314 PALPLENQV----WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           P  P E Q+    WYHG +SR  AE LLR   +  +LVR+S T+   + L+   +    H
Sbjct: 465 PIAPTEEQLRQEPWYHGRMSRRAAEKLLR--ADGDFLVRDSVTNPGQYVLTGMHAGQPKH 522

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
           + L    + + V+      F S+  ++ ++    LPI  AE
Sbjct: 523 LLLV---DPEGVVRTKDVLFESISHLIDYHLKNGLPIVAAE 560


>UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Eutheria
           RepID=SH23A_HUMAN
          Length = 576

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 8/107 (7%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L  Q WYHG +SR  AE LL+  +   +LVR S +   +  +S +     +H ++ R   
Sbjct: 10  LAGQPWYHGLLSRQKAEALLQ--QNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67

Query: 378 H------KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                    +       F S+P +VH Y + + P+  A    +  PV
Sbjct: 68  RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPV 114


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 27/99 (27%), Positives = 47/99 (47%), Gaps = 8/99 (8%)

Query: 311 WTDPALPLENQVWYHGAISRTDAE-NLLRLCK-EASYLVRNSETSKNDFSLSLKS----- 363
           +  P   ++ + WY G + R DAE  LL       ++L+R SET+K  +SLS++      
Sbjct: 137 YVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMK 196

Query: 364 SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
                H K+ +     Y +      F ++ ++V HY+ R
Sbjct: 197 GDHVKHYKIRKLDNGGYYI-TTRAQFETLQQLVQHYSER 234


>UniRef50_B1H1T7 LOC100158303 protein n=3 Tax=Xenopus RepID=B1H1T7_XENLA
          Length = 211

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 9/138 (6%)

Query: 286 PPRLSAGNPKSAKPLSMEPSSPLGEW--TDPALP-LENQVWYHGAISRTDAENLLRLCKE 342
           P  + A   + A  LS    S  G++   + AL  LE   +Y   +S T+A+NLL     
Sbjct: 15  PSSIFAAMNRQAAQLSYHYKSFCGDYERVETALERLEASGYYWSTLSGTEAKNLLSDQPV 74

Query: 343 ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY---VLGQNSP-PFSSVPEIVHH 398
            S+L+R+S    + F+LSL++S G  ++++       Y   V G  +P  F  V ++V H
Sbjct: 75  GSFLIRDSSDHHHLFTLSLRTSAGITNLRIKLEGPSFYLETVAGAETPHTFPCVVKLVEH 134

Query: 399 YASRKLPIKGAEHMSLLY 416
           Y   +L   G    +L Y
Sbjct: 135 YM--RLTATGESDSNLCY 150


>UniRef50_D2H965 Putative uncharacterized protein (Fragment) n=3 Tax=Amniota
           RepID=D2H965_AILME
          Length = 453

 Score = 44.7 bits (104), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 3/96 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ++   A  LL  C+  S+L+R SE  K  ++LS  S  G  H  +  + +    L
Sbjct: 347 WFHGILTLKRANELLSTCEPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADSYSFL 405

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           G +    +++  +V ++  ++ PI       LLYP 
Sbjct: 406 GVDRLRHATLAALVDYH--KEEPITSLGKELLLYPC 439


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score = 44.7 bits (104), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 27/89 (30%), Positives = 52/89 (58%), Gaps = 3/89 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEAS--YLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +E++ W+ G ISR++A   L+    A+  +L+R SE    D+ LS++ +Q   H K+ R 
Sbjct: 73  VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
              +  L + +  F S+PE+V+++ ++ L
Sbjct: 133 AGGRLHLNE-AVSFLSLPELVNYHRAQSL 160


>UniRef50_Q567F1 Zgc:112091 n=3 Tax=Euteleostomi RepID=Q567F1_DANRE
          Length = 284

 Score = 44.7 bits (104), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+  + SR  AE  L   +  ++L+R S++S  DFS+S++      H K+ + K   Y L
Sbjct: 58  WFKESASRGSAEETLMSREVGAFLIRGSQSSPGDFSISVRHDYDVQHFKVMKDKSGHYYL 117

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
              +  F+S+ ++V  Y +  +
Sbjct: 118 W--TEKFTSLNKLVDFYKTTSI 137


>UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7P6T2_IXOSC
          Length = 702

 Score = 44.7 bits (104), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 26/109 (23%), Positives = 46/109 (42%), Gaps = 8/109 (7%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           + +  WYHG I R  AE L+    +  +LVR+  +   D+ L+       +H  +++   
Sbjct: 23  MRSHAWYHGTIPRQRAEELMT--ADGGFLVRDCVSRPGDYVLTCCWKGAPLHFVINKVVL 80

Query: 378 HKYVLGQN------SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             Y + +          F +VP++V  Y   K PI  A    +  P  +
Sbjct: 81  QPYTVYERIQYQFEDDCFDTVPDLVTFYVGNKRPISAASGAVVSRPYVV 129


>UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=1 Tax=Schistosoma
           mansoni RepID=C4QLR4_SCHMA
          Length = 409

 Score = 44.7 bits (104), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 18/108 (16%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS------RTK 376
           WY G +SR+ AENLLR   +  +LVR S      F LS      + H+ L+      RTK
Sbjct: 310 WYVGKMSRSQAENLLRY--DGDFLVRASIQQPGQFVLSGLQDGKYRHLLLADPNGKVRTK 367

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAIRTL 423
           E           F S+  ++ ++     PI+  +  + L++PV+  T 
Sbjct: 368 ER---------VFDSIQHLIDYHVQNGAPIRSLDSEIRLIFPVSTHTF 406


>UniRef50_Q96JZ2 Hematopoietic SH2 domain-containing protein n=170 Tax=root
           RepID=HSH2D_HUMAN
          Length = 352

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 22/60 (36%), Positives = 33/60 (55%), Gaps = 1/60 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HGAISR DAENLL      S+L+R S  S   ++LS K+     H  +    +  +++
Sbjct: 34  WFHGAISREDAENLLESQPLGSFLIRVSH-SHVGYTLSYKAQSSCCHFMVKLLDDGTFMI 92


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 23/77 (29%), Positives = 40/77 (51%), Gaps = 2/77 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+    SR+ AE LLR      +++R  ++S  +FS+S++      H K+ R    +Y L
Sbjct: 58  WFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFKVMRDSRGQYFL 117

Query: 383 GQNSPPFSSVPEIVHHY 399
              S  F+S+ ++V  Y
Sbjct: 118 W--SEKFTSLNKLVDFY 132


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 36/105 (34%), Positives = 53/105 (50%), Gaps = 16/105 (15%)

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSL 361
           PS+ + E    A  +E + W++  I+R DAE  L     K  SYL+R SETSK  +SLS+
Sbjct: 112 PSNYVAE----ADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSI 167

Query: 362 K--SSQG---FMHMKLSRTKEHKYVLGQNSP--PFSSVPEIVHHY 399
           +   +QG     H K+       Y +   SP   FS +  ++ HY
Sbjct: 168 RDVDAQGQDVVKHYKIRSLDNGGYYI---SPKITFSDISSMIKHY 209


>UniRef50_B2MW85 Phosphatidylinositol 3-kinase 60 n=1 Tax=Bombyx mori
           RepID=B2MW85_BOMMO
          Length = 577

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 31/108 (28%), Positives = 54/108 (50%), Gaps = 5/108 (4%)

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           P   LE   WY G I+R +A   LR  ++ ++LVRN+    + ++L+++        KL 
Sbjct: 190 PEHSLEAAEWYWGDITRDEANEKLRDTRDGTFLVRNASNKDSGYTLTVRKGGA---NKLI 246

Query: 374 RTKEHKYVLGQNSP-PFSSVPEIVHHYASRKL-PIKGAEHMSLLYPVA 419
           +   H+   G   P  F SV ++V +Y+   L     +  + LLYP++
Sbjct: 247 KIYHHEGRYGFREPFEFKSVVDLVCYYSEYSLATCNSSLDIKLLYPLS 294


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 25/79 (31%), Positives = 44/79 (55%), Gaps = 2/79 (2%)

Query: 323 WYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+H  +S  +AE LL    K  +YLVR S +S   F++S+K++   +   +  +K  K+ 
Sbjct: 140 WFHAGLSGPEAERLLLAEGKHGTYLVRESHSSPGQFAISVKAADDKVIHVMIYSKSDKFD 199

Query: 382 LGQNSPPFSSVPEIVHHYA 400
           +G     FS++ E++ HY 
Sbjct: 200 IG-GGATFSTISELLEHYT 217


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 13/132 (9%)

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
           ++ AG+  S +P + +P+          L LE + +YHGA+ R + E L  L  +  ++V
Sbjct: 181 KVRAGHDSSHEPSNNQPTE---------LRLEEEEFYHGALPRKETEAL--LVNDGDFVV 229

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           R    +   + LS K +    H  +    E+ Y L      F +V E++    + + P+ 
Sbjct: 230 REKSDAWGRYVLSAKHASKVRHFPIQINDENMYRL--EGDAFQTVGELIRFQLNSRQPVT 287

Query: 408 GAEHMSLLYPVA 419
            A    LL PV 
Sbjct: 288 KASQAILLKPVC 299


>UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorhabditis elegans
           RepID=Q9TYT3_CAEEL
          Length = 316

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 4/87 (4%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           +VWYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++   H  L     H  
Sbjct: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHNR 265

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIK 407
           V  ++   FS++ E++ ++ +  + ++
Sbjct: 266 VRTRDR-TFSNISELIDYHVNNGMAVR 291


>UniRef50_UPI000052380F PREDICTED: similar to phosphoinositide-3-kinase, regulatory subunit
           3 (p55, gamma) n=1 Tax=Ciona intestinalis
           RepID=UPI000052380F
          Length = 552

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 26/83 (31%), Positives = 46/83 (55%), Gaps = 4/83 (4%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L++Q WY G+++R +    L   ++ ++LVRNS  S  +++L+L+        KL R   
Sbjct: 157 LQDQEWYWGSVTREEVNAQLSDEQDGTFLVRNSANSDREYTLTLRKGGS---NKLIRIMS 213

Query: 378 HKYVLGQNSP-PFSSVPEIVHHY 399
              + G   P  F+SV ++V+HY
Sbjct: 214 RNGMYGFAEPLIFNSVIQLVNHY 236


>UniRef50_UPI0000F2151D PREDICTED: similar to SH2B adapter protein 3 (Lymphocyte-specific
           adapter protein Lnk) (Signal transduction protein Lnk)
           (Lymphocyte adapter protein) n=2 Tax=Danio rerio
           RepID=UPI0000F2151D
          Length = 596

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 5/108 (4%)

Query: 318 LENQVWYHGAISRTDAENLLR---LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           L +  W+HG ISR  A  L++   +    ++LVR SET + D+ L+        H++LS 
Sbjct: 431 LSSYSWFHGPISRVRAAYLVQHAGVSGHGNFLVRQSETRRGDYVLTFNYQGRAKHLRLSL 490

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           T+  +  +      F SV +++ H+ +  +P++      ++    +R 
Sbjct: 491 TEWGQCRVQHLR--FPSVMDMLSHFRNCPIPLECGAACDVMLANYVRV 536


>UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=Neoptera
           RepID=Q17DJ2_AEDAE
          Length = 564

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 37/156 (23%), Positives = 71/156 (45%), Gaps = 27/156 (17%)

Query: 277 PGREEKGRLPP----RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
           P R E+GR+       L+ G+ + A  +  + ++ + E+           W+HG ++R++
Sbjct: 379 PPRREEGRISSSSNFELTEGDLEQAHEVDTDLTAMMREYP----------WFHGTLARSE 428

Query: 333 AENLLR---LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP- 388
           A  L+    L     +LVR SET K +F L+        H++++        LGQ     
Sbjct: 429 AAQLVLHNGLSSHGVFLVRQSETRKGEFVLTFNFQGKAKHLRMTLND-----LGQCRVQH 483

Query: 389 --FSSVPEIVHHYASRKLPIK--GAEHMSLLYPVAI 420
             F S+ E++ H+    +P++  G   ++L   V +
Sbjct: 484 LWFPSITEMLEHFRQHPIPLESGGTADVTLTNFVVL 519


>UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SCW1_NEMVE
          Length = 275

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 3/82 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYHG + R + E +L       +LVR+S T   D+ LS+  S    H  ++  K   Y +
Sbjct: 9   WYHGVLKRVETEGILNGKPPGVWLVRDSTTIPGDYVLSVSESGKVSHYIINN-KGTMYTI 67

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
           G  +  F  +P I+  Y    L
Sbjct: 68  GDQT--FPDLPSIIEFYKKHFL 87


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 23/77 (29%), Positives = 44/77 (57%), Gaps = 2/77 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG I+R+DAE+LL   K+  +LVR S     D+++ +  +    H ++   K++K  +
Sbjct: 108 WFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGDYTMCVSFAGEVEHYRVI-FKDNKVTI 166

Query: 383 GQNSPPFSSVPEIVHHY 399
            +    F ++ ++V HY
Sbjct: 167 DEEE-YFENLTKLVEHY 182


>UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1E0A
          Length = 680

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 33/112 (29%), Positives = 52/112 (46%), Gaps = 9/112 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG + R  AE LL   +   +LVR+S ++  D+ L+       MH K+ R   
Sbjct: 16  LSSHAWYHGPLRREAAEALLE--RNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVL 73

Query: 376 ---KEHKYVLGQ-NSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
              K +   L Q     F ++P ++  Y   + PI  A    + +P+  RTL
Sbjct: 74  RPKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQASGAVISHPIT-RTL 124


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score = 44.3 bits (103), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 33/93 (35%), Positives = 50/93 (53%), Gaps = 11/93 (11%)

Query: 318 LENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLK--SSQG--FMHMK 371
           LE + W+  +  R +AE  L   + K  S+L+R SET+K  FSLS+K  ++QG    H K
Sbjct: 119 LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYK 178

Query: 372 LSRTKEHKYVLGQNSP--PFSSVPEIVHHYASR 402
           +    E  Y +   SP   F S+  +V HY+ +
Sbjct: 179 IRCLDEGGYYI---SPRITFPSLQALVQHYSKK 208


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score = 43.9 bits (102), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 28/83 (33%), Positives = 42/83 (50%), Gaps = 5/83 (6%)

Query: 319 ENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           ENQ WYHG + R  AE  LR   +  SYLVR S+     + LS     G  H +++    
Sbjct: 74  ENQ-WYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRITAVCG 132

Query: 378 HKYVLGQNSPPFSSVPEIVHHYA 400
             Y+ G+    F+S+ ++V +Y 
Sbjct: 133 DYYIGGRQ---FNSLMDLVAYYT 152


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score = 43.9 bits (102), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 27/80 (33%), Positives = 40/80 (50%), Gaps = 4/80 (5%)

Query: 323 WYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WYHG + R  AE+ LR   K  SYLVR S+     + LS     G  H +++      Y+
Sbjct: 84  WYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSYYGRTGINHFRITAVCGDFYI 143

Query: 382 LGQNSPPFSSVPEIVHHYAS 401
            G+    F S+ ++V +Y S
Sbjct: 144 GGRQ---FISLSDLVGYYTS 160


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score = 43.9 bits (102), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 33/110 (30%), Positives = 59/110 (53%), Gaps = 6/110 (5%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMK 371
           D  + L++  WY G ISR +  + LR   + ++LVR++ T  + D++L+L+       +K
Sbjct: 55  DSFISLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIK 114

Query: 372 LSRTKEHKYVLGQNSP-PFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVA 419
           +   ++ KY  G + P  F+SV E+++HY    L        + L YPV+
Sbjct: 115 IYH-RDGKY--GFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVS 161


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 43.9 bits (102), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 24/79 (30%), Positives = 44/79 (55%), Gaps = 2/79 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+   I+R +AE LL   +  ++LVR SE+S+  +SLS+K ++   H ++ +    K+ L
Sbjct: 14  WFFPTITRKNAELLLMQERNGAFLVRRSESSEGLYSLSVKYNESVQHFRILQDTAGKFHL 73

Query: 383 GQNSPPFSSVPEIVHHYAS 401
                 F S+  +V +Y +
Sbjct: 74  W--IVKFPSLDALVDYYRT 90


>UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SMI9_TETNG
          Length = 609

 Score = 43.9 bits (102), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 33/112 (29%), Positives = 52/112 (46%), Gaps = 9/112 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG + R  AE LL   +   +LVR+S ++  D+ L+       MH K+ R   
Sbjct: 16  LSSHAWYHGPLRREAAEALLE--RNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVL 73

Query: 376 ---KEHKYVLGQ-NSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
              K +   L Q     F ++P ++  Y   + PI  A    + +P+  RTL
Sbjct: 74  RPKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQASGAVISHPIT-RTL 124


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score = 43.9 bits (102), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 22/57 (38%), Positives = 34/57 (59%), Gaps = 1/57 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           E+  W+HG +SR  A++LL+   E  ++LVR S T+  DF LSL   +   H ++ R
Sbjct: 6   ESMKWFHGNLSREAADDLLKQGYEDGTFLVRESSTAAGDFVLSLLCQEEVCHYQVRR 62


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score = 43.9 bits (102), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 24/72 (33%), Positives = 41/72 (56%), Gaps = 2/72 (2%)

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
           ++R  AE LL+   + ++L+R SE +  D+SLS+K   G  H K+ R    KY L     
Sbjct: 28  VTRDGAEELLKNDGDGAFLIRESEGTPGDYSLSVKFVDGVQHFKVLRDGAGKYFLW--VV 85

Query: 388 PFSSVPEIVHHY 399
            F+S+ ++V ++
Sbjct: 86  KFNSLNQLVEYH 97


>UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00006A1C30
          Length = 514

 Score = 43.9 bits (102), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 13/110 (11%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF-MHMKLSRT- 375
           L +  WYHG + R DAE L  L     +L+R+S +S  D+ LS   + G  +H K+    
Sbjct: 23  LRSHAWYHGPLPRQDAERL--LVSNGDFLIRDSISSPGDYVLSCFCAGGQPLHFKIIAVA 80

Query: 376 -------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                      Y L Q+   F ++P +V  Y   +  +  +    ++ PV
Sbjct: 81  LRPRRGIARTLYQLEQDQ--FDNIPALVRSYVGDRRKVSESTGAVIIRPV 128


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score = 43.9 bits (102), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 9/101 (8%)

Query: 314 PALPLENQV----WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           P  P E Q+    WYHG +SR  AE +LR   +  +LVR+S T+   + L+   +    H
Sbjct: 474 PVAPTEEQLRQEPWYHGRMSRRAAERMLR--ADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
           + L    + + V+      F S+  ++ H+     PI  AE
Sbjct: 532 LLLV---DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAE 569


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score = 43.9 bits (102), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 4/79 (5%)

Query: 323 WYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           + HG ISR + + L+R     E  +LVR S  +  D++LS+ +     H K+SR K   Y
Sbjct: 30  YMHGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALSVVAQGKLQHFKISR-KTGLY 88

Query: 381 VLGQNSPPFSSVPEIVHHY 399
            +  + P F S+ E+V  Y
Sbjct: 89  RI-DDGPGFGSLDELVQFY 106


>UniRef50_A9V0V2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V0V2_MONBE
          Length = 1762

 Score = 43.9 bits (102), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 29/106 (27%), Positives = 55/106 (51%), Gaps = 7/106 (6%)

Query: 307 PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
           PLG   D    + +  W+HG + RT A+ LL   ++ ++LVR  + + + ++L++++   
Sbjct: 873 PLGNHCDAEFQVYS--WFHGLLDRTGADLLLEDTEDGTFLVRVCQ-AYHGYALAMRTPTR 929

Query: 367 FMHMKLS-RTKEHKY-VLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
             H K+   T  H Y V G     F S+ +++ H+  ++ PI   E
Sbjct: 930 TQHFKIELNTTTHCYAVSGHPELSFDSLNKLIQHF--KQQPIGNFE 973


>UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo salar
           RepID=B5X487_SALSA
          Length = 289

 Score = 43.5 bits (101), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+    SR+ AE LL   +   +L+R S++S  +FS+S++      H K+ +  +  Y L
Sbjct: 58  WFKETASRSSAEELLMSREVGGFLIRGSQSSPGEFSISVRHEFDVQHFKVMKDSKGHYFL 117

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
              S  F+S+ ++V  Y +  +
Sbjct: 118 W--SEKFTSLNKLVDFYKNTSI 137


>UniRef50_P51813 Cytoplasmic tyrosine-protein kinase BMX n=52 Tax=Coelomata
           RepID=BMX_HUMAN
          Length = 675

 Score = 43.5 bits (101), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 28/88 (31%), Positives = 51/88 (57%), Gaps = 7/88 (7%)

Query: 318 LENQVWYHGAISRTDAENLLRL-CKEASYLVRNSE----TSKNDFSLSLKSSQGFM-HMK 371
           L++  W+ G ISR+ +E LLR   KE +++VRNS      + + FS ++   +G + H  
Sbjct: 291 LDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYH 350

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           +    E+K  L +N   F S+P+++H++
Sbjct: 351 VHTNAENKLYLAENY-CFDSIPKLIHYH 377


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score = 43.5 bits (101), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 36/129 (27%), Positives = 59/129 (45%), Gaps = 21/129 (16%)

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPL----ENQVWYHGAISRTDAENLLRLCKEA 343
           ++S  N +    L+ +      E  +P LPL    +++ WYHG ++R  AE+L  L  + 
Sbjct: 259 QISGKNKEICDLLASKKFYSTTEIQEPKLPLYSSLQHEEWYHGKMNRKVAESL--LVNDG 316

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKL------SRTKEHKYVLGQNSPPFSSVPEIVH 397
            +L+R S TS   + LS        H+ L       RTK+H          F SV  ++ 
Sbjct: 317 DFLIRESTTSACQYVLSGLQGGHPKHLLLVDPDGKVRTKDH---------VFESVIHLIS 367

Query: 398 HYASRKLPI 406
           ++   +LPI
Sbjct: 368 YHMENELPI 376


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score = 43.5 bits (101), Expect = 0.016,   Method: Compositional matrix adjust.
 Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           LE   W HGAISR  A+ LL+    +  YLVR S++    ++L +      +H ++++  
Sbjct: 69  LELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPGQYTLDVWKEGKSVHYRITKGD 128

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR 402
           E  +   +    F ++PE++ H+ +R
Sbjct: 129 EGYFF--RQGVCFPTIPELIQHHQTR 152


>UniRef50_A9VBC5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VBC5_MONBE
          Length = 382

 Score = 43.5 bits (101), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 3/79 (3%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKN-DFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY GA+ R +AE+LLR     ++ VR   +S+       +   + F H+++  T E    
Sbjct: 262 WYLGAVDRKEAEDLLRAWPTGTFAVRKGRSSRVITLKFPVAKDKVFFHVRI--TYEEPMY 319

Query: 382 LGQNSPPFSSVPEIVHHYA 400
              +S  F S+PE+V  Y 
Sbjct: 320 RVADSECFRSIPELVAFYV 338


>UniRef50_A8Q3U8 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q3U8_BRUMA
          Length = 1284

 Score = 43.5 bits (101), Expect = 0.017,   Method: Composition-based stats.
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P    +W+     R  AE LL   ++  ++L+R S T KN F LSL+      H  L R 
Sbjct: 671 PHLGMIWFCEKTDRNRAEELLNTVQQDGAFLLRFSSTDKNVFVLSLRVDGEIWHYHLKRD 730

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                +   N   F ++ +IV +Y++R+  ++G   + L YPV   T+
Sbjct: 731 GR---IFVVNQTIFENLNQIVEYYSTREF-VRG---ICLKYPVGEDTI 771


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score = 43.1 bits (100), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 13/117 (11%)

Query: 312 TDPALPLENQVWYHGAISRTDAENLLR---LCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
           TD    +    W+HG ++R++A  L+    +     +LVR SET K +F L+        
Sbjct: 428 TDLTAMMREYPWFHGTLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTFNFQGKAK 487

Query: 369 HMKLSRTKEHKYVLGQNSPP---FSSVPEIVHHYASRKLPIK--GAEHMSLLYPVAI 420
           H++++        LGQ       F S+ E++ H+    +P++  G   ++L   V +
Sbjct: 488 HLRMTLND-----LGQCRVQHLWFPSITEMLEHFRQHAIPLESGGTADVTLTNFVVL 539


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score = 43.1 bits (100), Expect = 0.018,   Method: Compositional matrix adjust.
 Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 2/77 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG ISR  AE+LL   ++  +LVR S     D++L +       H ++ + K  K  +
Sbjct: 101 WFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLCVCFQDQVDHYRM-QGKNGKLTI 159

Query: 383 GQNSPPFSSVPEIVHHY 399
            +    FSS+ E+V HY
Sbjct: 160 DEEV-YFSSLEELVQHY 175


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score = 43.1 bits (100), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 24/87 (27%), Positives = 45/87 (51%), Gaps = 5/87 (5%)

Query: 318 LENQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL---- 372
           + +++WYHG ++R  +E  LL    + S++VR SE+    ++LS+  +      ++    
Sbjct: 1   MSDEIWYHGRVNRQQSEELLLSAAVDGSFVVRASESRAGAYALSVLFNNSVHTYRILPTE 60

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           + T   + V G     F S+ E+VH Y
Sbjct: 61  NNTLAVQTVNGVQQRKFKSLTELVHEY 87


>UniRef50_UPI00017B4774 UPI00017B4774 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B4774
          Length = 132

 Score = 43.1 bits (100), Expect = 0.019,   Method: Composition-based stats.
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 5/84 (5%)

Query: 324 YHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           YHGAI R   E LL +  K+ +YL+R+SET      L +   +     +L +T+   Y+L
Sbjct: 5   YHGAIGRKTCEELLGKKNKDGAYLIRDSETVPGAMCLCVFKGRVVYTYRLLKTRSGDYML 64

Query: 383 ----GQNSPPFSSVPEIVHHYASR 402
               G     F ++ +++ HY  R
Sbjct: 65  MVADGIEETYFKNLEDLIRHYKRR 88


>UniRef50_Q6GP30 MGC80721 protein n=2 Tax=Xenopus RepID=Q6GP30_XENLA
          Length = 508

 Score = 43.1 bits (100), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 29/104 (27%), Positives = 55/104 (52%), Gaps = 7/104 (6%)

Query: 318 LENQVWYHGAISRTDAENLLR-LCKEASYLVRNS--ETSKNDFSLSLKSSQGFMHMKLSR 374
           L    WY G ISR++AE  LR + ++ ++LVRNS   T+ + + L +       ++++ +
Sbjct: 390 LSQDQWYTGNISRSEAETALRSINQDGTFLVRNSSKSTASHPYVLMVLYRNKVYNIQIRQ 449

Query: 375 TKEHK-YVLG---QNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
            + +  Y+LG   +    F+SV EI+ ++    L +   +  SL
Sbjct: 450 DQTNNVYMLGSGLRGQETFASVMEIIDYFHKTPLLLIDGKDQSL 493


>UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SW52_TETNG
          Length = 338

 Score = 43.1 bits (100), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WY G + R +A+N L+  K   +LVR+S T   D+ LS+  +    H  ++     ++ +
Sbjct: 14  WYFGPVLRPEAQNRLQGQKHGMFLVRDSSTCPGDYVLSVSENSKVSHYIITSLPNKRFKI 73

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
           G     F  +P ++  Y    L
Sbjct: 74  GDRE--FEHLPALLEFYKYHYL 93


>UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS
          Length = 727

 Score = 43.1 bits (100), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 8/94 (8%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ-------GFMHMKLS 373
           + WY   +SR DA  LL   +  ++LVR+S T KN + L ++ +Q          H  + 
Sbjct: 464 KFWYKANLSREDAIALLASAQPGTFLVRDSTTYKNAYGLVVRVAQPPAGSQELVRHFLIE 523

Query: 374 RTKEHKYVLG-QNSPPFSSVPEIVHHYASRKLPI 406
            T+E   + G  N P F+S+  +V  ++  +L +
Sbjct: 524 PTREGVRLKGCDNEPVFTSLSALVFEHSINRLAL 557


>UniRef50_B5X244 SH2 domain-containing protein 2A n=2 Tax=Salmo salar
           RepID=B5X244_SALSA
          Length = 534

 Score = 43.1 bits (100), Expect = 0.020,   Method: Compositional matrix adjust.
 Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 15/129 (11%)

Query: 284 RLPPRLSAGNPKSAKPLSMEPSSPLGEWTD---------PALPLENQVWYHGAISRTDAE 334
           R+PP L+ G P   +PLS    +    W +         P  P+    W HG  +R +AE
Sbjct: 82  RVPPALTLGGPGPLEPLSPSLRAHTLLWFERTQLPRLCRPGRPMPR--WLHGFATRREAE 139

Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK---YVLGQNSPPFSS 391
            LL+  ++  +L+R SE SK  F LS +      H  +   +  +   Y++       SS
Sbjct: 140 ELLKDKQQGCFLLRLSE-SKIGFVLSYRGKDRCRHFIIEEEEGGRGACYLIAGEKSRHSS 198

Query: 392 VPEIVHHYA 400
           + E+V +Y 
Sbjct: 199 LQELVSYYT 207


>UniRef50_B3S7K1 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3S7K1_TRIAD
          Length = 864

 Score = 43.1 bits (100), Expect = 0.021,   Method: Compositional matrix adjust.
 Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 4/95 (4%)

Query: 318 LENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           +EN   Y+  +S   AE+LLRL  ++ ++L+R S      F+LS++    F H ++    
Sbjct: 1   MENLANYYIDVSYEQAEDLLRLEDQDGAFLIRPSHRVPGTFALSIRYRNKFFHHRIKVFH 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH 411
                 G     FSS+ E+V H+   + P +G  H
Sbjct: 61  GRFVCEGFTEKTFSSMDELVKHF---RQPNQGLAH 92


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...   612   e-174
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...   323   9e-87
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...   299   2e-79
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...   287   5e-76
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...   283   7e-75
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...   273   7e-72
UniRef50_Q4S861 Chromosome 5 SCAF14709, whole genome shotgun seq...   255   2e-66
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...   245   2e-63
UniRef50_UPI00006A214E SH2 domain-containing adapter protein E. ...   212   3e-53
UniRef50_A4II17 Shd protein (Fragment) n=3 Tax=Xenopus (Silurana...   212   3e-53
UniRef50_C3ZPI6 Putative uncharacterized protein n=2 Tax=Branchi...   193   8e-48
UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=...   187   8e-46
UniRef50_UPI0001925BB9 PREDICTED: similar to Shb=Src homology 2 ...   182   3e-44
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   177   6e-43
UniRef50_Q6PD21-2 Isoform 2 of SH2 domain-containing adapter pro...   177   8e-43
UniRef50_Q4RIA8 Chromosome 8 SCAF15044, whole genome shotgun seq...   173   7e-42
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...   173   1e-41
UniRef50_UPI00016E0CC8 UPI00016E0CC8 related cluster n=1 Tax=Tak...   162   4e-38
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...   161   4e-38
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   160   8e-38
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...   158   3e-37
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...   158   4e-37
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...   154   6e-36
UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU...   151   4e-35
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...   150   8e-35
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   150   1e-34
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          149   2e-34
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   149   2e-34
UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=...   149   2e-34
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...   148   3e-34
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   148   3e-34
UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS         147   6e-34
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   147   6e-34
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   147   9e-34
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          146   2e-33
UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 doma...   143   1e-32
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   141   5e-32
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   140   1e-31
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   138   3e-31
UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=...   138   4e-31
UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 doma...   136   2e-30
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   133   1e-29
UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA ...   133   1e-29
UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni Re...   133   1e-29
UniRef50_Q5BWZ4 SJCHGC04657 protein (Fragment) n=1 Tax=Schistoso...   133   1e-29
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   130   8e-29
UniRef50_Q0P4A0 Shd protein n=5 Tax=Clupeocephala RepID=Q0P4A0_D...   126   1e-27
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   123   1e-26
UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=...   123   1e-26
UniRef50_UPI0000D9E9A9 PREDICTED: similar to src homology 2 doma...   120   1e-25
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   119   2e-25
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   119   2e-25
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   119   2e-25
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS         119   3e-25
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI         117   6e-25
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   117   7e-25
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   116   1e-24
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   116   1e-24
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   116   2e-24
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   116   2e-24
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   116   2e-24
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...   115   3e-24
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   115   4e-24
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   115   4e-24
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   115   5e-24
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   114   5e-24
UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni Re...   114   6e-24
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   114   6e-24
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...   114   7e-24
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...   114   7e-24
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...   114   8e-24
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...   113   9e-24
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   113   9e-24
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   113   1e-23
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   113   1e-23
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   113   1e-23
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   112   2e-23
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   112   3e-23
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   111   5e-23
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...   111   6e-23
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...   110   9e-23
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   110   1e-22
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   109   2e-22
UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3...   109   2e-22
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...   109   2e-22
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   109   2e-22
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   109   2e-22
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   109   2e-22
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...   108   3e-22
UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, part...   108   5e-22
UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio Rep...   108   6e-22
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   107   8e-22
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   107   8e-22
UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 ...   107   1e-21
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...   106   1e-21
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...   106   1e-21
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   106   1e-21
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   106   2e-21
UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniot...   106   2e-21
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   105   2e-21
UniRef50_B8JL24 Novel protein similar to human and mouse SH2 dom...   105   2e-21
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...   105   3e-21
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...   105   4e-21
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     105   4e-21
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE        105   4e-21
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   104   5e-21
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...   104   6e-21
UniRef50_UPI000186E9A4 SH2 domain-containing protein 4A, putativ...   104   6e-21
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   104   8e-21
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...   104   9e-21
UniRef50_UPI0001555700 PREDICTED: similar to hCG34612 n=1 Tax=Or...   103   1e-20
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...   103   1e-20
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...   103   1e-20
UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis R...   103   1e-20
UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containi...   102   2e-20
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   102   3e-20
UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia mal...   102   3e-20
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...   101   4e-20
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...   101   4e-20
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   101   4e-20
UniRef50_UPI0001758844 PREDICTED: similar to vav1 n=1 Tax=Tribol...   101   5e-20
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   101   5e-20
UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome ...   101   6e-20
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...   101   6e-20
UniRef50_A8P112 Variant SH3 domain containing protein n=1 Tax=Br...   101   6e-20
UniRef50_UPI0000E48AB6 PREDICTED: similar to B-cell linker n=1 T...   101   7e-20
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...   101   7e-20
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...    99   1e-19
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...    99   1e-19
UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Eutele...    99   2e-19
UniRef50_UPI000180B9A8 PREDICTED: similar to Protein vav-2 n=1 T...    99   2e-19
UniRef50_UPI0000D9F428 PREDICTED: similar to Src homology 2 doma...    98   5e-19
UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=...    98   8e-19
UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixo...    97   1e-18
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA     97   1e-18
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...    97   2e-18
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...    97   2e-18
UniRef50_A9V1A4 Predicted protein (Fragment) n=1 Tax=Monosiga br...    96   3e-18
UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=...    95   4e-18
UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga...    95   5e-18
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...    94   7e-18
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...    94   8e-18
UniRef50_A6NKC9 SH2 domain-containing protein 7 n=4 Tax=Euteleos...    94   9e-18

Sequences not found previously or not previously below threshold:

UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   116   1e-24
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   111   6e-23
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   110   8e-23
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   110   1e-22
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   109   2e-22
UniRef50_UPI000186F2CC Phosphatidylinositol 3-kinase regulatory ...   107   7e-22
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   107   7e-22
UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID...   107   1e-21
UniRef50_UPI000052380F PREDICTED: similar to phosphoinositide-3-...   106   1e-21
UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun se...   106   1e-21
UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepI...   106   2e-21
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...   105   3e-21
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   105   3e-21
UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona...   105   4e-21
UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tet...   104   6e-21
UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis...   104   6e-21
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   104   7e-21
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...   104   7e-21
UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n...   104   7e-21
UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pe...   104   8e-21
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   103   1e-20
UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosi...   103   1e-20
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   103   1e-20
UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis R...   103   1e-20
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   103   1e-20
UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=...   103   1e-20
UniRef50_B2MW85 Phosphatidylinositol 3-kinase 60 n=1 Tax=Bombyx ...   103   2e-20
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...   102   2e-20
UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Eute...   102   2e-20
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   102   3e-20
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   102   3e-20
UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q...   102   3e-20
UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis R...   101   3e-20
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...   101   4e-20
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   101   4e-20
UniRef50_UPI000069EA62 SH2 domain-containing protein 4A (Protein...   101   5e-20
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...   101   5e-20
UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine ph...   101   5e-20
UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis...   101   5e-20
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   101   6e-20
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME        101   7e-20
UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 ...    99   1e-19
UniRef50_UPI00017930CA PREDICTED: similar to SH2 domain containi...    99   2e-19
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...    99   2e-19
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    99   2e-19
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   100   2e-19
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...    99   2e-19
UniRef50_O14544 Suppressor of cytokine signaling 6 n=31 Tax=Eute...    99   2e-19
UniRef50_A9UNJ0 Predicted protein n=1 Tax=Monosiga brevicollis R...    99   3e-19
UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_D...    99   3e-19
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...    99   3e-19
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...    99   3e-19
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...    99   3e-19
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...    99   3e-19
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS          99   3e-19
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...    99   3e-19
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...    99   3e-19
UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Tak...    98   4e-19
UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicin...    98   4e-19
UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n...    98   5e-19
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...    98   5e-19
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...    98   6e-19
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...    98   6e-19
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...    98   6e-19
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...    98   6e-19
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...    98   8e-19
UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Na...    98   8e-19
UniRef50_B0XFC9 Phosphatidylinositol 3-kinase regulatory subunit...    97   8e-19
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...    97   9e-19
UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE       97   1e-18
UniRef50_UPI000179134F PREDICTED: similar to signal transduction...    97   1e-18
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...    97   1e-18
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...    97   1e-18
UniRef50_C3Z699 Putative uncharacterized protein n=1 Tax=Branchi...    97   1e-18
UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR          97   1e-18
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...    97   2e-18
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...    97   2e-18
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...    97   2e-18
UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tet...    97   2e-18
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...    96   2e-18
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...    96   2e-18
UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X...    96   2e-18
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...    96   3e-18
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...    96   3e-18
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    96   3e-18
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...    96   3e-18
UniRef50_D2H965 Putative uncharacterized protein (Fragment) n=3 ...    96   3e-18
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...    96   3e-18
UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain pr...    96   3e-18
UniRef50_P70305 Phosphoinositide 3-kinase p85alpha (Fragment) n=...    96   3e-18
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...    96   3e-18
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...    95   4e-18
UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome ...    95   4e-18
UniRef50_UPI0000D56E93 PREDICTED: similar to predicted protein n...    95   4e-18
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...    95   5e-18
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...    95   5e-18
UniRef50_UPI000180B456 PREDICTED: similar to SH2 domain-containi...    95   5e-18
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...    95   6e-18
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...    95   6e-18
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...    95   6e-18
UniRef50_P05433 P47(GAG-CRK) protein n=1 Tax=Avian sarcoma virus...    95   7e-18
UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME          94   8e-18
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...    94   8e-18
UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2...    94   9e-18
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...    94   9e-18
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...    94   9e-18
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...    94   9e-18

>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score =  612 bits (1578), Expect = e-174,   Method: Composition-based stats.
 Identities = 419/423 (99%), Positives = 421/423 (99%)

Query: 1   MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 60
           MQQEGGPVRSAPCRTGTLEGSRQGSPGH+KRASPKGSLSSAQPHSWMLTPSPLNSHCAHR
Sbjct: 58  MQQEGGPVRSAPCRTGTLEGSRQGSPGHKKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 117

Query: 61  EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 120
           EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG
Sbjct: 118 EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 177

Query: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGE 180
           SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT EGE
Sbjct: 178 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGE 237

Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
           GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS
Sbjct: 238 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 297

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL
Sbjct: 298 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 357

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
           SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS
Sbjct: 358 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 417

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           LKSSQGFMHMKLSRTK +KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI
Sbjct: 418 LKSSQGFMHMKLSRTKNNKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 477

Query: 421 RTL 423
           RTL
Sbjct: 478 RTL 480


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score =  323 bits (827), Expect = 9e-87,   Method: Composition-based stats.
 Identities = 249/322 (77%), Positives = 255/322 (79%), Gaps = 48/322 (14%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPL 161
           LAILEDYADPFDVQETGEGS G SGAP KVPENDGYMEPYEAQKMMAEIRGSKETA QPL
Sbjct: 173 LAILEDYADPFDVQETGEGSGGTSGAPGKVPENDGYMEPYEAQKMMAEIRGSKETAAQPL 232

Query: 162 PLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
           PLYDTPYEPE++GA+ EGEG PWPRESRLPEDDERPPEEYD                   
Sbjct: 233 PLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERPPEEYD------------------- 273

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
                                        P     E   +  +AQFEG E +CLSPGREE
Sbjct: 274 ----------------------------QPWEWKKERISKAFAAQFEGSE-NCLSPGREE 304

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 341
           KGRLPPRLSAGNPKSAKPL MEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK
Sbjct: 305 KGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 364

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS
Sbjct: 365 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 424

Query: 402 RKLPIKGAEHMSLLYPVAIRTL 423
           RKLPIKGAEHMSLLYPVAIRTL
Sbjct: 425 RKLPIKGAEHMSLLYPVAIRTL 446


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score =  299 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 190/326 (58%), Positives = 223/326 (68%), Gaps = 55/326 (16%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR--GSKETATQ 159
           +AI+EDYADPFD ++      G+  APEKV ENDGYMEPYEAQKMMAEIR  GSKE    
Sbjct: 184 VAIVEDYADPFDAKQV----PGSQNAPEKVTENDGYMEPYEAQKMMAEIRRRGSKELPCT 239

Query: 160 PLPLYDTPYEPEEDGATAEGEGA--PWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
           PL LYDTPYEP E+G  +EGE +    PRESRLP+DDERPPEEYDQP  W+ ++      
Sbjct: 240 PLHLYDTPYEPSENGLDSEGEKSTSQRPRESRLPQDDERPPEEYDQP--WEWKK------ 291

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSP 277
                                                  E   +  +AQF+  +K+ ++ 
Sbjct: 292 ---------------------------------------ERISKAFAAQFDSADKTGMAA 312

Query: 278 GREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL 337
            +E+K R   R SAGN K+ K  S+E    +GE  DP+LPLE+Q WYHGAISR DAE+LL
Sbjct: 313 AKEDKPRHMHRHSAGNLKAIKHPSVEHCISVGERIDPSLPLESQFWYHGAISRADAESLL 372

Query: 338 RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
           RLCKEASYLVRNSET+K DFSLSLKS QGFMHMKLSRTKE+KYVLG NSPPF+SVPEI+H
Sbjct: 373 RLCKEASYLVRNSETNKIDFSLSLKSIQGFMHMKLSRTKENKYVLGHNSPPFNSVPEIIH 432

Query: 398 HYASRKLPIKGAEHMSLLYPVAIRTL 423
           HYAS+KLPIKGAEHMSLLYPVA+RTL
Sbjct: 433 HYASQKLPIKGAEHMSLLYPVAVRTL 458


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score =  287 bits (734), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 159/326 (48%), Positives = 194/326 (59%), Gaps = 60/326 (18%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQP- 160
           + I +DY+DPFD +   +  AG         E+ GYMEPYEAQ++M E +  +   +Q  
Sbjct: 240 VTIADDYSDPFDAKNDLKSKAGK-------GESAGYMEPYEAQRIMTEFQRQESVRSQHK 292

Query: 161 -LPLYDTPYEPEEDGATAEGEGA--PWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
            + LYDTPYEPE     ++ E    P  RES+LP+DD+RP +EYDQPWEW +  I     
Sbjct: 293 GIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTI----- 347

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSP 277
                                                         +AQF G EK   SP
Sbjct: 348 -------------------------------------------PALAAQFNGNEKRQSSP 364

Query: 278 GREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL 337
                 R   R   G  K  K  S E    LGE  DPA+PLE Q+WYHGAISR DAENLL
Sbjct: 365 SPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLL 424

Query: 338 RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
           RLCKE SYLVRNS+TSK+D+SLSL+S+QGFMHMKL++TKE KYVLGQNSPPF SVPE++H
Sbjct: 425 RLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSVPEVIH 483

Query: 398 HYASRKLPIKGAEHMSLLYPVAIRTL 423
           +Y +RKLPIKGAEH+SLLYPVA+RTL
Sbjct: 484 YYTTRKLPIKGAEHLSLLYPVAVRTL 509


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score =  283 bits (724), Expect = 7e-75,   Method: Composition-based stats.
 Identities = 216/286 (75%), Positives = 222/286 (77%), Gaps = 48/286 (16%)

Query: 138 MEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERP 197
           MEPYEAQKMMAEIRGSKETA QPLPLYDTPYEPE++GA+ EGEG PWPRESRLPEDDERP
Sbjct: 1   MEPYEAQKMMAEIRGSKETAAQPLPLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERP 60

Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
           PEEYD                                                P     E
Sbjct: 61  PEEYD-----------------------------------------------QPWEWKKE 73

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
              +  +AQFEG E +CLSPGREEKGRLPPRLSAGNPKSAKPL MEPSSPLGEWTDPALP
Sbjct: 74  RISKAFAAQFEGSE-NCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALP 132

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE
Sbjct: 133 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 192

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
Sbjct: 193 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 238


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score =  273 bits (698), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 154/350 (44%), Positives = 203/350 (58%), Gaps = 64/350 (18%)

Query: 83  RSTTRLRIIRLRDRLEPR----PLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYM 138
           RS   L  + L +  +P     P+    DY+DPFDV+      +      +  PEN+GYM
Sbjct: 97  RSKILLSSVSLEEPTDPVVPSAPVMGDTDYSDPFDVRLDPRPESAQG---QITPENNGYM 153

Query: 139 EPYEAQKMMAEIR-----GSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPED 193
           EPYEAQK++ E++     G+       + LYD PYE    G     E     RESRLP+D
Sbjct: 154 EPYEAQKVITELQRRAGGGAGGWGRGEVQLYDAPYEERVPGQPDLPEEG---RESRLPQD 210

Query: 194 DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
           D+RP +EYDQPWEWKKE ISKAFAV  +  +                             
Sbjct: 211 DDRPADEYDQPWEWKKEHISKAFAVQFEGAEW---------------------------- 242

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
                            ++SC    R    R PP  + G+ K  KP   +P S +GE  D
Sbjct: 243 -----------------DRSCSPTERLRCSRAPP--TTGSMKLRKPS--DPHSMIGERVD 281

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           P+LPLE QVWYHG++SR++AE+LL LCKE SYLVRNSETS+ D+SLSL+S QGFMHMK S
Sbjct: 282 PSLPLEKQVWYHGSLSRSEAESLLTLCKECSYLVRNSETSRLDYSLSLRSCQGFMHMKFS 341

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           + K+ +Y+LGQNSPPF ++PE++H+Y + KLPIKGAEH+SLL+PV ++TL
Sbjct: 342 QCKDGRYILGQNSPPFETIPEVIHYYTTHKLPIKGAEHLSLLFPVLVQTL 391


>UniRef50_Q4S861 Chromosome 5 SCAF14709, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4S861_TETNG
          Length = 775

 Score =  255 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 153/316 (48%), Positives = 192/316 (60%), Gaps = 53/316 (16%)

Query: 142 EAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEY 201
           +  +     RG KE + + LPLYDTPYEP E+G  ++ E +  PRESRLP+DDERPPEEY
Sbjct: 479 DEIRSGGTGRGPKEGSVRQLPLYDTPYEPAENGGDSDPERSRCPRESRLPQDDERPPEEY 538

Query: 202 DQPWEWKKERISKAFA---------------------------------VDIKVIKDLPW 228
           DQPWEWKKERISKAFA                                 V+IKVIK+LPW
Sbjct: 539 DQPWEWKKERISKAFAALLCYDCISYEGSVSDTGSGSHGGKDCTSNSLTVEIKVIKNLPW 598

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
           PPPVGQL+S+P++ +     +  A   P       + QF+G EKS +SP ++ K R   R
Sbjct: 599 PPPVGQLNSTPTVVEELESPTQTAQAPP-----GQTFQFDGVEKSRMSPTKDGKTRPLQR 653

Query: 289 LSAGNPKSAKPLSMEPSSP-LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
            S+G   + K  S+E   P L E  DP++PLE+Q+             L +LC     ++
Sbjct: 654 HSSGCLVNTKMSSLEHCGPSLAERIDPSMPLESQL-------------LCQLCSNCRVVI 700

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           R +   +  F   L+SSQGFMHMKLSRTKE+KY+LGQNS PF SVPEI+H Y+S KLPIK
Sbjct: 701 R-AAVKRRVFPCVLRSSQGFMHMKLSRTKENKYILGQNSCPFDSVPEIIHFYSSCKLPIK 759

Query: 408 GAEHMSLLYPVAIRTL 423
           GAEHMSLLYPVAIRTL
Sbjct: 760 GAEHMSLLYPVAIRTL 775



 Score = 62.2 bits (149), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 29/47 (61%), Positives = 34/47 (72%), Gaps = 2/47 (4%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMA 148
           L ILEDYADPFD ++ G G+  +    +   ENDGYMEPYEAQKMMA
Sbjct: 296 LIILEDYADPFDAEQAGGGTQTS--TEKVTTENDGYMEPYEAQKMMA 340


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score =  245 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 140/352 (39%), Positives = 182/352 (51%), Gaps = 94/352 (26%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRG--------- 152
           + ILEDYADP+D + T           E+V ENDGYMEPY+AQ+M+ EIR          
Sbjct: 198 VIILEDYADPYDAKRTKGQRDA-----ERVGENDGYMEPYDAQQMITEIRRRGSKDPLVK 252

Query: 153 --------------------------SKETATQPLPLYDTPYEPEEDGATAEGEGAPWPR 186
                                     SK+   +P  LYDTPYEP E G  AEG+    P 
Sbjct: 253 ALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKA--RPP 310

Query: 187 ESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDR 246
           +SRLPE+DERP  EY+QP  W+ ++                                   
Sbjct: 311 DSRLPENDERPAAEYEQP--WEWKK----------------------------------- 333

Query: 247 DISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSS 306
                     E  +   S QFEG E+      REE  R   R  +   K  KP   + S 
Sbjct: 334 ----------EQIVRALSVQFEGAERPSF---REETVRQHHRQKSWTQKILKPALSDHSE 380

Query: 307 PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
             GE  DP LPLE Q WYHGAISR +AE+ L+ CKEA YLVRNSE+  + +S++LK+SQG
Sbjct: 381 --GEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQG 438

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            +H+ +++TK++KY L Q S  F S+PE+VH+Y++ KLP KGAEHM+LLYPV
Sbjct: 439 CVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490


>UniRef50_UPI00006A214E SH2 domain-containing adapter protein E. n=1 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A214E
          Length = 437

 Score =  212 bits (538), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 123/351 (35%), Positives = 177/351 (50%), Gaps = 90/351 (25%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR---------- 151
           + I+E+YA P+D + T +         E++ ENDGYMEPY+AQ+M+ EIR          
Sbjct: 144 IIIIENYAIPYDAKCTKDPRDA-----ERLGENDGYMEPYDAQQMITEIRRRGSKDNLIT 198

Query: 152 --------------------GSKETATQPLPLYDTPYEPEEDGATAEG-EGAPWPRESRL 190
                               GS+E   +   LYDTPYEP + G  AE  E      +   
Sbjct: 199 ELLLLELGPPCGLKTVVRRPGSQELLDRAPQLYDTPYEPPDAGGEAEPQENKGSAGDGTR 258

Query: 191 PEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISG 250
           PE+DERP  EY+QP  W+ ++                                       
Sbjct: 259 PENDERPAGEYEQP--WEWKK--------------------------------------- 277

Query: 251 PASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE 310
                 E  +   S QFE  E+   SP +EE GR   R  +  PK  K    E     G+
Sbjct: 278 ------EHIVRALSVQFENSER---SPSKEEPGRSHQRQKSWTPKVLKQHQAEQ----GD 324

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
             DP +PLE Q WYHG+++R  AE+LL  C EASYL+RNS +  + +S++LK+SQG +H+
Sbjct: 325 KVDPTVPLEKQSWYHGSVTRDQAESLLDSCPEASYLLRNSGSGNSKYSIALKTSQGCVHI 384

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
            +++TK +K+ L Q    F+S+PE+VHHY+S+KLP KG++H+SLL+PV  +
Sbjct: 385 IVAQTKNNKFTLSQMCGAFNSIPEVVHHYSSQKLPFKGSKHISLLHPVPSK 435


>UniRef50_A4II17 Shd protein (Fragment) n=3 Tax=Xenopus (Silurana) tropicalis
           RepID=A4II17_XENTR
          Length = 379

 Score =  212 bits (538), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 86/306 (28%), Positives = 137/306 (44%), Gaps = 46/306 (15%)

Query: 117 TGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT 176
           + EG     G  E  PE+  YM+PYE+Q         +   T  L LYD PY+ ++   T
Sbjct: 119 SVEGKNELFGGEE--PEDIRYMDPYESQSTGLHCIMERAAGT-ALKLYDFPYQ-KQFHKT 174

Query: 177 AEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLD 236
             G        S+   +DERP +EYDQPWEWKK+ I++AFAV                  
Sbjct: 175 FHG--------SQQHLEDERPADEYDQPWEWKKDDINRAFAVQF---------------- 210

Query: 237 SSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKS 296
                     D    +    E  L+ S+  F   +K+        +    P+  A     
Sbjct: 211 -------EGSDWQQSSLTRTERLLQPSAKCFRRLQKNS--LSSSPESSTSPKQCAELTDE 261

Query: 297 AKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
               S+E  +      +P  PL+ QVWYHG +S+ +AE  L+ CK  S+++R  +    +
Sbjct: 262 CMAYSLEHGT-----LNP--PLQTQVWYHGKLSKLEAEKYLQNCKPGSFVIRIEQDI--E 312

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           + +S++ S    H+K+   +   ++LG++ P F+ + E+V HY    L ++  E + L  
Sbjct: 313 YFMSVRGSHSTQHLKVKCIENEHFMLGESGPSFTCILELVEHYMKHPLLLQNEEQLFLQC 372

Query: 417 PVAIRT 422
           PV   T
Sbjct: 373 PVFTVT 378


>UniRef50_C3ZPI6 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3ZPI6_BRAFL
          Length = 718

 Score =  193 bits (491), Expect = 8e-48,   Method: Composition-based stats.
 Identities = 84/295 (28%), Positives = 134/295 (45%), Gaps = 33/295 (11%)

Query: 98  EPRPLAILEDYADPFDVQETGEGSAGASGAPEKVP--END--GYMEPYEAQKMMAEIRGS 153
           +P    +L+DY+DP+D+++    S      P+  P  E+D   Y +PY+AQK++ E+R  
Sbjct: 265 KPMKPIVLDDYSDPYDIRKAVLESRDYDVPPDCRPPKEDDFNNYSDPYDAQKIIQELRIQ 324

Query: 154 KE-TATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERI 212
           +   A +  P   TP   + +G++++      P E   PED +    +     E +K + 
Sbjct: 325 QSKEAKEETPRSSTP---DSEGSSSDSALYEDPYEPSAPEDIDADTHQARLARELEKAKE 381

Query: 213 SKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK 272
           ++      +  +      P    D        +R     A+ L +             ++
Sbjct: 382 TQLKQQQQQQQQPDEDTRPAEDYDQPWEWSSKERLSQAFAAQLDQ-------------QQ 428

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLS-----MEPSSPLGEWTDPALPLENQVWYHGA 327
               P          RL+A    SA PLS      + S    E  DP++PLE Q WYHG+
Sbjct: 429 PSPPPSTHTPPSADKRLAAVPESSASPLSKTRVFRKHSHEGSEPIDPSIPLEGQRWYHGS 488

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           ISR DAEN+LR C+E S+LVRNSE+S+ +FSLS+K             ++  Y L
Sbjct: 489 ISRVDAENVLRSCRECSFLVRNSESSRTNFSLSIKMEDK-------ECRDRGYFL 536


>UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=Euteleostomi
           RepID=SHD_HUMAN
          Length = 340

 Score =  187 bits (473), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 117/316 (37%), Positives = 153/316 (48%), Gaps = 81/316 (25%)

Query: 107 DYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDT 166
           +Y DPFD Q            P   P +DGYMEPY+AQ +M+E+ G        + LYDT
Sbjct: 105 EYLDPFDAQ------------PHPAPPDDGYMEPYDAQWVMSELPGR------GVQLYDT 146

Query: 167 PYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDL 226
           PYE +      + E A  P   + P     P E+     E+                   
Sbjct: 147 PYEEQ------DPETADGPPSGQKPRQSRMPQEDERPADEYD------------------ 182

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
                                   P     +      + QF+ PE        +E  R P
Sbjct: 183 -----------------------QPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRPP 219

Query: 287 PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
           P                 S    E  DPALPLE Q W+HG ++R DAE+LL LCKE SYL
Sbjct: 220 P----------------RSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYL 263

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           VR SET+  D SLSL+SSQGF+H+K +RT+E++ VLGQ+S PF SVPE+V HY+SR LP+
Sbjct: 264 VRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPV 323

Query: 407 KGAEHMSLLYPVAIRT 422
           +GAEH++LLYPV  +T
Sbjct: 324 QGAEHLALLYPVVTQT 339


>UniRef50_UPI0001925BB9 PREDICTED: similar to Shb=Src homology 2 protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001925BB9
          Length = 419

 Score =  182 bits (460), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 82/310 (26%), Positives = 124/310 (40%), Gaps = 68/310 (21%)

Query: 82  WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
           W + +      L ++    P    +DY+DP+D ++    S            +D Y EPY
Sbjct: 149 WDTFSGKNKKDLENKQNSVPTKKKDDYSDPWDSKKCTSKSYDEF--------DDTYSEPY 200

Query: 142 EAQK---MMAEIRGSKETATQPLPLYDTPYE--------PEEDGATAEG---------EG 181
           +  K   M +    S+    +   LYD PYE        P+ +G              + 
Sbjct: 201 DKNKHTVMDSTPHASESDVEEHAELYDMPYEERVILGVEPKINGNLKNPAPHLQPVPPQH 260

Query: 182 APWPRESRLPEDDERPPE-EYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
           AP+      P     P   EYD PWEWK + +   F     V            ++S+ S
Sbjct: 261 APYSSAKPKPSSSILPTAGEYDAPWEWKMKDVEADFEKRFSVG-----------VESASS 309

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNP-----K 295
           +               +P L  S      P K  +   R +           NP     +
Sbjct: 310 I---------------KPPLNSSH-----PNKKPVPAVRNQSITSINTAVVANPVQKPAR 349

Query: 296 SAKPLSMEPSSPLGE---WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
           S K +S+  +  L       DP +PL+NQ W+HGAI R  AE+LL+   + SYL+R+SE+
Sbjct: 350 SNKDVSVSKAEDLSRKEYEVDPTIPLKNQGWFHGAIRRDYAEDLLKSMPDCSYLIRDSES 409

Query: 353 SKNDFSLSLK 362
           SK ++SLSLK
Sbjct: 410 SKLNYSLSLK 419



 Score = 46.5 bits (108), Expect = 0.002,   Method: Composition-based stats.
 Identities = 37/197 (18%), Positives = 67/197 (34%), Gaps = 23/197 (11%)

Query: 103 AILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLP 162
              ++Y DP+D +E       +         ND Y +P++A K   +++ SK   T    
Sbjct: 79  IKKDEYQDPWDSKEMSNNDKSSKL-------NDTYEDPFDAMKSENDLQTSKTLKTSK-- 129

Query: 163 LYDTPYEPEEDGATAEGEGAPWPRESRLPEDD---------ERPPEEYDQPWEWKKERIS 213
              T  E +     ++    PW   S   + D          +  ++Y  PW+ KK   S
Sbjct: 130 --STDNENDSKTLPSDTYIDPWDTFSGKNKKDLENKQNSVPTKKKDDYSDPWDSKKCT-S 186

Query: 214 KAFAVDIKVIKDLPWPPPVGQLDSSP--SLPDGDRDISGPASPLPEPSLEDSSAQFEGPE 271
           K++        +         +DS+P  S  D +        P  E  +     +  G  
Sbjct: 187 KSYDEFDDTYSEPYDKNKHTVMDSTPHASESDVEEHAELYDMPYEERVILGVEPKINGNL 246

Query: 272 KSCLSPGREEKGRLPPR 288
           K+     +    +  P 
Sbjct: 247 KNPAPHLQPVPPQHAPY 263


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  177 bits (449), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 87/192 (45%), Positives = 118/192 (61%), Gaps = 6/192 (3%)

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQ------FEGPEKSCLSPGREEKGRLPPRLSA 291
           +   P         A       +E   AQ      FE  +    +   +E  R       
Sbjct: 130 ARPDPRPRPGWEQNAVEACSSYMEPFEAQRFINVTFEAADWDQCTLPCDEALRKAGVSRV 189

Query: 292 GNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSE 351
             P S      +P   LGE  DP LPLE QVWYHGA++R++AE+LL LCKE SYLVR S+
Sbjct: 190 SPPSSGATSLRKPHGILGERVDPMLPLEKQVWYHGALTRSEAESLLTLCKECSYLVRKSQ 249

Query: 352 TSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH 411
           TS+ND+SLSL+S  GFMHMK S++++ K++LG+NSPPF S+PE++H Y + KLPI+GAEH
Sbjct: 250 TSRNDYSLSLRSCHGFMHMKFSQSRDGKFILGENSPPFDSIPEVIHFYTTNKLPIRGAEH 309

Query: 412 MSLLYPVAIRTL 423
           +SLL+PV ++TL
Sbjct: 310 LSLLFPVLVQTL 321



 Score = 44.1 bits (102), Expect = 0.009,   Method: Composition-based stats.
 Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 6/69 (8%)

Query: 83  RSTTRLRIIRLRDRLEPR----PLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYM 138
           RS T L I+   +   P     P+    DY+DPFD +       G      +      YM
Sbjct: 95  RSKTPLNIVTFEEPQAPVVPSAPVVGETDYSDPFDARPDPRPRPGWEQNAVEAC--SSYM 152

Query: 139 EPYEAQKMM 147
           EP+EAQ+ +
Sbjct: 153 EPFEAQRFI 161


>UniRef50_Q6PD21-2 Isoform 2 of SH2 domain-containing adapter protein B n=4
           Tax=Amniota RepID=Q6PD21-2
          Length = 217

 Score =  177 bits (447), Expect = 8e-43,   Method: Composition-based stats.
 Identities = 96/232 (41%), Positives = 117/232 (50%), Gaps = 52/232 (22%)

Query: 138 MEPYEAQKMMAEIRGSKETATQP--LPLYDTPYEPEEDGATAEGEGAP--WPRESRLPED 193
           MEPYEAQ++M E +  +   +Q   + LYDTPYEPE     ++ E       RES+LP+D
Sbjct: 1   MEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSLRLRESKLPQD 60

Query: 194 DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
           D+RP +EYDQPWEW +  I                                         
Sbjct: 61  DDRPADEYDQPWEWNRVTI----------------------------------------- 79

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
                     +AQF G EK   SP      R   R   G  K  K  S E    LGE  D
Sbjct: 80  -------PALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVD 132

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
           P +PLE Q+WYHGAISR+DAENLLRLCKE SYLVRNS+TSK+D+SLSL  + 
Sbjct: 133 PTIPLEKQIWYHGAISRSDAENLLRLCKECSYLVRNSQTSKHDYSLSLNYAD 184


>UniRef50_Q4RIA8 Chromosome 8 SCAF15044, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RIA8_TETNG
          Length = 253

 Score =  173 bits (439), Expect = 7e-42,   Method: Composition-based stats.
 Identities = 99/320 (30%), Positives = 145/320 (45%), Gaps = 71/320 (22%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPL 161
           L ILEDYADPFD ++T E         E+   NDGYMEPY+AQ ++   RGSK+     +
Sbjct: 1   LIILEDYADPFDAEKTKEQREA-----ERAGVNDGYMEPYDAQVIITGERGSKDLLKVCV 55

Query: 162 PLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
            L        + G           RE +  E    P   YD P+E + +   +   + + 
Sbjct: 56  LL--------DRGQ----------REGKREEGHPLPLNIYDTPYEGELDGDREGVWIPVT 97

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
             +    PP   +L       D  R +S P                              
Sbjct: 98  RPESDIRPPGEYELPWEWRKEDIVRALSVP----------------------------HR 129

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 341
            GR      A   +S   +  E S                 WYHG++SR  AE  L+ C+
Sbjct: 130 MGRWLKWTPASPWRSRGEVGGEGS-----------------WYHGSVSRQQAEAQLQRCR 172

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK---YVLGQNSPPFSSVPEIVHH 398
           EAS+LVR+SE+  + +S++LK+SQ  +H+ +++TK  K   + L Q+S  F S+PE+VHH
Sbjct: 173 EASFLVRDSESGTSKYSIALKTSQSCVHIIVAQTKGVKGLGFTLDQSSCVFPSIPELVHH 232

Query: 399 YASRKLPIKGAEHMSLLYPV 418
           Y + +LP  GAEHM+L +PV
Sbjct: 233 YCTHRLPFTGAEHMTLQHPV 252


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score =  173 bits (437), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 66/156 (42%), Positives = 102/156 (65%), Gaps = 4/156 (2%)

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAI 328
           G  K  L+    E G+ PP+   G       L++  + P  +  D ++PL+ Q WYHG+I
Sbjct: 685 GFFKQSLTLNLNECGQRPPK-KFGTLDLG--LNLGTNRPNVDLIDASIPLDRQGWYHGSI 741

Query: 329 SRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSP 387
           SR DAE +LR   E S+LVRNSE+++ D+SL+LKS++GFMHM++ R  +  +++LGQ S 
Sbjct: 742 SRIDAEKILRPLSEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDADSGQFILGQFSR 801

Query: 388 PFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           PF ++P+++ H+   +LP++GAEHM LL PV  + L
Sbjct: 802 PFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQIL 837


>UniRef50_UPI00016E0CC8 UPI00016E0CC8 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E0CC8
          Length = 215

 Score =  162 bits (408), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 99/174 (56%), Positives = 121/174 (69%), Gaps = 3/174 (1%)

Query: 151 RGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKE 210
           RG KE + + LPLYDTPYEP E+G  ++ E    PRESRLP+DDERPPEEYDQPWEWKKE
Sbjct: 14  RGPKEGSVRQLPLYDTPYEPAENGGDSDPEHPRVPRESRLPQDDERPPEEYDQPWEWKKE 73

Query: 211 RISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP--EPSLEDSSAQFE 268
           RISKAFAV+IKVIKDLPWPPPVGQL+S+P + +     S  A PL    P    SS QF+
Sbjct: 74  RISKAFAVEIKVIKDLPWPPPVGQLNSTPPVVEELESPSQTAQPLQVNHPFFTSSSVQFD 133

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP-LGEWTDPALPLENQ 321
           G +KS +SP ++ K R   R S G   + K  S++  SP L E  DP++PLE+Q
Sbjct: 134 GVDKSRMSPTKDGKARPLQRHSGGCLVNTKMSSLDHCSPSLAERIDPSMPLESQ 187


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score =  161 bits (407), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 66/115 (57%), Positives = 90/115 (78%), Gaps = 1/115 (0%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  DP+LPLE Q WYHG+I+R +AE+LLR  KE SYLVRNSE++K D+SLSLKS++GFMH
Sbjct: 1081 DLIDPSLPLEKQTWYHGSITRVEAEDLLRSLKEGSYLVRNSESAKQDYSLSLKSAKGFMH 1140

Query: 370  MKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++       +++LGQ S PF+S+P+++ HY+  KLPI+GAEHM LL PVA + L
Sbjct: 1141 MRIQIDNNSGQFILGQFSKPFNSIPDMIRHYSVNKLPIRGAEHMCLLKPVAAQLL 1195


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  160 bits (404), Expect = 8e-38,   Method: Composition-based stats.
 Identities = 49/188 (26%), Positives = 84/188 (44%), Gaps = 8/188 (4%)

Query: 234 QLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGN 293
            L  +      +  ++GP+    +P+L  +   F     + LS  + EK R+      G 
Sbjct: 293 GLSEAARWNSKENLLAGPSEN--DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGE 350

Query: 294 PKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS 353
              A+  + +   P   +  P   LE   WYHG +SR  AE+LL      S+LVR SE+S
Sbjct: 351 WCEAQTKNGQGWVP-SNYITPVNSLEKHSWYHGPVSRNAAEHLLSSGINGSFLVRESESS 409

Query: 354 KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS 413
               S+SL+      H +++   + K  +   S  F+++ E+VHH+++    +      +
Sbjct: 410 PGQRSISLRYEGRVYHYRINTASDGKLYVSSES-RFNTLAELVHHHST----VADGLITT 464

Query: 414 LLYPVAIR 421
           L YP   R
Sbjct: 465 LHYPAPKR 472


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score =  158 bits (399), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 84/283 (29%), Positives = 129/283 (45%), Gaps = 7/283 (2%)

Query: 142 EAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEY 201
           E  K+   +  +K          D   +  + G + +         SR  +  + P   +
Sbjct: 622 ETMKVKRRLPQNKNLLNLGFHAGDLEIQGSDSGISIQSREGIK---SRQQDFSDLP---F 675

Query: 202 DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLE 261
           D P   ++  I++                P         L       S  +      S+ 
Sbjct: 676 DMPKLRRRRMITQDACTSGSATSVDLRDLPFDMPKLRRRLRIQPSTESSVSQASSSQSVI 735

Query: 262 DSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQ 321
           ++  Q             E   R  P L          L+   + P  +  D  LPLE Q
Sbjct: 736 EADRQVSSFRPKLTLNLGELDLRQRPGLGLSLVGLGMNLNNPENPPTADVIDVNLPLEKQ 795

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-KEHKY 380
            W+HGAI+R +AEN+LR+ +E S+LVRNSE++K D+SLSLKS++GFMHM++ +   +  Y
Sbjct: 796 GWFHGAITRVEAENVLRMLREGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDGNDECY 855

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           +LGQ S PF S+PE++ H+   +LPI+GAEHM LL PV  + L
Sbjct: 856 ILGQFSKPFHSIPEMIRHFCINRLPIRGAEHMCLLQPVIAQLL 898


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score =  158 bits (398), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 69/140 (49%), Positives = 96/140 (68%), Gaps = 1/140 (0%)

Query: 285  LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
              P    G      PL +  +    +  D  LPLE Q WYHG+I+R +AE +LRL +E S
Sbjct: 983  QLPPKKPGGLSLGLPLEINTARGSADLVDVGLPLERQGWYHGSITRIEAEAVLRLLREGS 1042

Query: 345  YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRK 403
            YLVRNSE++K D+SLSLKS++GFMHM++ + +E + Y+LGQ S PF S+PE+V H++  +
Sbjct: 1043 YLVRNSESTKQDYSLSLKSARGFMHMRIQKNEELNAYILGQFSKPFDSIPEMVRHFSVNR 1102

Query: 404  LPIKGAEHMSLLYPVAIRTL 423
            LPI+GAEHM LL+PV  + L
Sbjct: 1103 LPIRGAEHMCLLHPVIAQLL 1122


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score =  154 bits (389), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 76/223 (34%), Positives = 117/223 (52%), Gaps = 7/223 (3%)

Query: 202  DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLE 261
            D P++  K R  +      + I+ L  P   G L  + +   G    S   S     +  
Sbjct: 865  DLPFDMPKLR-RRLRMPQNQQIQQLAVPSTSGILLQTSTESSGLSQASSSLSMRDSDNRA 923

Query: 262  DSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQ 321
             + A   G  K  L+    E     P    G       L+   +    +  D ++ L+ Q
Sbjct: 924  AALA--GGFFKQSLTLNLNEC-SAKPVKKFGTLDFG--LNFNTARSNVDLIDASISLDRQ 978

Query: 322  VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKY 380
             WYHG+ISR DAE +LR   E S+LVRNSE+++ D+SL+LKS++GFMHM++ R  +  +Y
Sbjct: 979  GWYHGSISRIDAEKILRPLGEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDPDSSQY 1038

Query: 381  VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            +LGQ S PF ++P+++ H+   +LP++GAEHM LL PV  + L
Sbjct: 1039 ILGQFSRPFPTIPDMIRHFCLNRLPVRGAEHMCLLEPVIAQIL 1081


>UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU33_DROPE
          Length = 1444

 Score =  151 bits (381), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 63/161 (39%), Positives = 97/161 (60%), Gaps = 6/161 (3%)

Query: 269  GPEKSCLSPGREEKGRLPPRLSAGNPK---SAKPLSMEPSS---PLGEWTDPALPLENQV 322
               +  L+    E  +   +  + + +   S K L+M          +  D ++PLE Q 
Sbjct: 1284 ALFRQNLTLNLNEPRQATKQFGSLDLRGLNSTKELNMNLCQGYVTAVDLIDVSIPLERQG 1343

Query: 323  WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
            WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK ++GFMHM++ R +  +Y+L
Sbjct: 1344 WYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNETGQYIL 1403

Query: 383  GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            GQ S PF +VP+++ H+   +LP++GAEHM L+ PV  + L
Sbjct: 1404 GQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1444


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score =  150 bits (379), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 65/161 (40%), Positives = 97/161 (60%), Gaps = 6/161 (3%)

Query: 269  GPEKSCLSPGREEKGRLPPRLSAGNPK---SAKPLSMEPSS---PLGEWTDPALPLENQV 322
               +  L+    E  +   +  + + +   S K L+M  S       +  D  +PLE Q 
Sbjct: 1350 ALFRQNLTLNLNESRQATKQFGSLDLRGLNSNKELNMNLSQGYVTAVDLIDVTIPLERQG 1409

Query: 323  WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
            WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK ++GFMHM++ R +  +Y+L
Sbjct: 1410 WYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNETGQYIL 1469

Query: 383  GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            GQ S PF +VPE++ H+   +LP++GAEHM L+ PV  + L
Sbjct: 1470 GQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1510


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  150 bits (378), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 8/212 (3%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
           +  +   +++  + + +        L  +      +  ++GP+    +P+L  +   F  
Sbjct: 356 KDPTTKNSLEKALQRPVASDFEPQGLSEAARWNSKEDLLAGPSEN--DPNLFVALYDFVA 413

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
              + LS  + EK R+      G    A+  + +   P   +  P   LE   WYHG +S
Sbjct: 414 SGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP-SNYITPVNSLEKHSWYHGPVS 472

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R  AE LL      S+LVR SE+S    S+SL+      H +++   + K  +   S  F
Sbjct: 473 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSES-RF 531

Query: 390 SSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +++ E+VHH+++    +      +L YP   R
Sbjct: 532 NTLAELVHHHST----VADGLITTLHYPAPKR 559


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  149 bits (375), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 50/177 (28%), Positives = 81/177 (45%), Gaps = 5/177 (2%)

Query: 246 RDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPS 305
            ++  P     +P L  +   F+   ++ LS  + E+ R+     +G    A   S    
Sbjct: 176 ENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVG 235

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
                +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+   
Sbjct: 236 WVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG 295

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYPVAIR 421
              H ++S   + K  + Q    F+++ E+VHH++   +P +G   ++ LLYP   +
Sbjct: 296 RVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHHS---VPHEGHGLITPLLYPAPKQ 348


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  149 bits (375), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 49/188 (26%), Positives = 83/188 (44%), Gaps = 8/188 (4%)

Query: 234 QLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGN 293
            L  +      +  ++GP+    +P+L  +   F     + LS  + EK R+      G 
Sbjct: 41  GLSEAARWNSKENLLAGPSEN--DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGE 98

Query: 294 PKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS 353
              A+  + +   P   +  P   LE   WYHG +SR  AE LL      S+LVR SE+S
Sbjct: 99  WCEAQTKNGQGWVP-SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESS 157

Query: 354 KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS 413
               S+SL+      H +++   + K  +   S  F+++ E+VHH+++    +      +
Sbjct: 158 PGQRSISLRYEGRVYHYRINTASDGKLYVSSES-RFNTLAELVHHHST----VADGLITT 212

Query: 414 LLYPVAIR 421
           L YP   R
Sbjct: 213 LHYPAPKR 220


>UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=Euteleostomi
           RepID=SHD_MOUSE
          Length = 343

 Score =  149 bits (375), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 99/316 (31%), Positives = 136/316 (43%), Gaps = 38/316 (12%)

Query: 107 DYADPF-DVQETGEGSAGASGAPEKVPENDGYM--EPYEAQKMMAEIRGSKETATQPLPL 163
           D+ DP+ D     E     SG P+        +  E  +  +  A +    E        
Sbjct: 41  DFEDPYEDSNGRAEPEVTGSGDPKYNSPRHRLIKVEAADMARAKALLGSPGEEPEAETEY 100

Query: 164 YDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVI 223
            D      +  A   G   P+   S   E   R  + YD P+E              +  
Sbjct: 101 SDPFDAQPQPPAPNSGYMEPYDARSVSSEQPSRAVQLYDTPYE--------------EQA 146

Query: 224 KDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKG 283
                    GQ            +   P     +      + QF+GP+        +E  
Sbjct: 147 TKPEDGGSSGQSRRPLEDERPADEYDQPWEWKKDHISRAFAVQFDGPDWERTPCSTKEPW 206

Query: 284 RLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEA 343
           R  P                      E  D AL LE Q W+HG +SR +AENLL LCKE 
Sbjct: 207 RPQP---------------------AERVDTALALEKQPWFHGPLSRAEAENLLSLCKEG 245

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
           SYLVR SET   D  LSL+S+QG MH+K +RT+E++ VLGQ+S PF S+PE+V HY++R 
Sbjct: 246 SYLVRLSETRAQDCILSLRSNQGSMHLKFARTRENQVVLGQHSGPFPSIPELVLHYSARP 305

Query: 404 LPIKGAEHMSLLYPVA 419
           LP++GAEH++LLYPV 
Sbjct: 306 LPVQGAEHLALLYPVT 321



 Score = 83.1 bits (203), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 68/277 (24%), Positives = 105/277 (37%), Gaps = 52/277 (18%)

Query: 98  EPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETA 157
           +P+P A    Y +P+D +                                     S E  
Sbjct: 107 QPQPPAPNSGYMEPYDARSV-----------------------------------SSEQP 131

Query: 158 TQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA 217
           ++ + LYDTPYE +      + E      +SR P +DERP +EYDQPWEWKK+ IS+AFA
Sbjct: 132 SRAVQLYDTPYEEQ----ATKPEDGGSSGQSRRPLEDERPADEYDQPWEWKKDHISRAFA 187

Query: 218 VDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS------SAQFEGPE 271
           V          P    +          D  ++    P     L  +      S   EG  
Sbjct: 188 VQFDGPDWERTPCSTKEPWRPQPAERVDTALALEKQPWFHGPLSRAEAENLLSLCKEGSY 247

Query: 272 KSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD--PALPLENQVWYHGAIS 329
              LS  R +   L  R + G+       + E    LG+ +   P++P     +    + 
Sbjct: 248 LVRLSETRAQDCILSLRSNQGSMHLKFARTRENQVVLGQHSGPFPSIPELVLHYSARPLP 307

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
              AE+L  L     Y V +S++S+   +L+ K  +G
Sbjct: 308 VQGAEHLALL-----YPVTSSQSSQGPCTLAAKPERG 339


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score =  148 bits (374), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 71/153 (46%), Positives = 99/153 (64%), Gaps = 1/153 (0%)

Query: 272  KSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
            K  L+       +L      G       L +  S    +  D  LPLE Q WYHG+I+R 
Sbjct: 1030 KMTLNLDGGNGQQLLGLKKPGGLNLGLSLELTASRGSADLVDVELPLERQGWYHGSITRI 1089

Query: 332  DAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFS 390
            +AE +LRL +E SYLVRNSE++K D+SLSLKS++GFMHM++ + +E + Y+LGQ S PF 
Sbjct: 1090 EAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNEELNAYILGQFSKPFD 1149

Query: 391  SVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            S+PE+V H++  +LPI+GAEHM LL+PV  + L
Sbjct: 1150 SIPEMVRHFSINRLPIRGAEHMCLLHPVIAQLL 1182


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  148 bits (373), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 54/235 (22%), Positives = 92/235 (39%), Gaps = 7/235 (2%)

Query: 188 SRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD 247
             +P          D   E ++ +                        +S+      +  
Sbjct: 121 PHIPAGSTAASLLADAA-ELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENL 179

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
           ++ P     +P L  +   F+   ++ LS  + E+ R+     +G    A   S      
Sbjct: 180 LA-PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWV 238

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
              +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+     
Sbjct: 239 PSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 298

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYPVAIR 421
            H ++S   + K  + Q    F+++ E+VHH++   +P +G   ++ LLYP   +
Sbjct: 299 YHYRISEDPDGKVFVTQE-AKFNTLAELVHHHS---VPHEGHGLITPLLYPAPKQ 349


>UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS
          Length = 1495

 Score =  147 bits (371), Expect = 6e-34,   Method: Composition-based stats.
 Identities = 63/161 (39%), Positives = 97/161 (60%), Gaps = 6/161 (3%)

Query: 269  GPEKSCLSPGREEKGRLPPRLSAGNPK---SAKPLSMEPSS---PLGEWTDPALPLENQV 322
               +  L+    E  +   +  + + +   S K L+M          +  D ++PLE Q 
Sbjct: 1335 ALFRQNLTLNLNEPRQATKQFGSLDLRGLNSTKELNMNLCQGYVTAVDLIDVSIPLERQG 1394

Query: 323  WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
            WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK ++GFMHM++ R +  +Y+L
Sbjct: 1395 WYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQRNETGQYIL 1454

Query: 383  GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            GQ S PF +VP+++ H+   +LP++GAEHM L+ PV  + L
Sbjct: 1455 GQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQLL 1495


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  147 bits (371), Expect = 6e-34,   Method: Composition-based stats.
 Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 6/213 (2%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
             + +   +   +             +S+      +  ++ P     +P L  +   F+ 
Sbjct: 161 AELQQDSGILSSMGGGGGHSSTTSVFESTHRWTSKENLLA-PGPEEDDPQLFVALYDFQA 219

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
             ++ LS  + E+ R+     +G    A   S         +  P   LE   WYHG IS
Sbjct: 220 GGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPIS 279

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R  AE LL      S+LVR SE+S    S+SL+      H ++S   + K  + Q    F
Sbjct: 280 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDPDGKVFVTQE-AKF 338

Query: 390 SSVPEIVHHYASRKLPIKGAEHMS-LLYPVAIR 421
           +++ E+VHH++   +P +G   ++ LLYP   +
Sbjct: 339 NTLAELVHHHS---VPHEGHGLITPLLYPAPKQ 368


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  147 bits (370), Expect = 9e-34,   Method: Composition-based stats.
 Identities = 51/210 (24%), Positives = 83/210 (39%), Gaps = 10/210 (4%)

Query: 212 ISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP----ASPLPEPSLEDSSAQF 267
           +   F  D                D  P   +     S       +   +P+L  +   F
Sbjct: 59  VEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDF 118

Query: 268 EGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGA 327
                + LS  + EK R+      G     +  + +   P   +  P   LE   WYHG 
Sbjct: 119 VASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVP-SNYITPVNSLEKHSWYHGP 177

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
           +SR+ AE LL      S+LVR SE+S    S+SL+      H +++ T + K  +   S 
Sbjct: 178 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAES- 236

Query: 388 PFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
            FS++ E+VHH+++    +      +L YP
Sbjct: 237 RFSTLAELVHHHST----VADGLVTTLHYP 262


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  146 bits (367), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 50/177 (28%), Positives = 81/177 (45%), Gaps = 5/177 (2%)

Query: 246 RDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPS 305
            ++  P     +P L  +   F+   ++ LS  + E+ R+     +G    A   S    
Sbjct: 185 ENLLEPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVG 244

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
                +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+   
Sbjct: 245 WVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG 304

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYPVAIR 421
              H ++S   + K  + Q    F+++ E+VHH++   +P +G   ++ LLYP   +
Sbjct: 305 RVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHHS---VPHEGHGLITPLLYPAPKQ 357


>UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=1 Tax=Macaca mulatta RepID=UPI0000D9EE2E
          Length = 221

 Score =  143 bits (360), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 72/153 (47%), Positives = 98/153 (64%), Gaps = 8/153 (5%)

Query: 276 SPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV------WYHGAIS 329
            P    + +  PR    N    +P+S+  +           P +         W+HG ++
Sbjct: 70  HPSLGLQEKRGPRCV--NLGLPEPVSLSGNGMTPPTRSTNTPGDTLCCCPIYGWFHGPLN 127

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R DAE+LL LCKE SYLVR SETS  D SLSL+SSQGF+H+K +RT+E++ VLGQ+S PF
Sbjct: 128 RADAESLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPF 187

Query: 390 SSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
            SVPE+V HY+SR LP++GAEH++LLYPV  +T
Sbjct: 188 PSVPELVLHYSSRPLPVQGAEHLALLYPVVTQT 220


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  141 bits (354), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 45/182 (24%), Positives = 74/182 (40%), Gaps = 4/182 (2%)

Query: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
           +   S+    ++    +    +P L  +   F+    + LS  + E+ R+     +G   
Sbjct: 87  NLESSIRWTSKENLLQSQEDDDPQLFVALYDFQAGGDNQLSLKKGEQVRILSYNKSGEWC 146

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKN 355
            A     +       +  P   LE   WYHG ISR  AE LL      S+LVR SE+S  
Sbjct: 147 EAHASPGQVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 206

Query: 356 DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
             S+SL+      H +++       V       F+++ E+VHH++     +       LL
Sbjct: 207 QRSISLRYEGRVYHYRINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLIT----QLL 262

Query: 416 YP 417
           YP
Sbjct: 263 YP 264


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  140 bits (351), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 48/177 (27%), Positives = 79/177 (44%), Gaps = 5/177 (2%)

Query: 246 RDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPS 305
            ++  P     +P L  +   F+   ++ LS  + E+ R+     +G    A   S    
Sbjct: 120 ENLLAPGPEEDDPQLFVALYDFKAGGENQLSLRKGEQVRILSYNKSGEWCEAHSDSGHVG 179

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
                +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+   
Sbjct: 180 WVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDG 239

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS-LLYPVAIR 421
              H ++S   + K  +      F+++ E+VHH++   +  +G   ++ LLYP   +
Sbjct: 240 RVYHYRISEDSDGKVYVTAE-AKFNTLAELVHHHS---VLHEGHGLITPLLYPAPKQ 292


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  138 bits (347), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 55/213 (25%), Positives = 89/213 (41%), Gaps = 10/213 (4%)

Query: 207 WKKERISKA-FAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSA 265
           W+  ++    F  D    + LP  P      +SP +   +           +P L     
Sbjct: 72  WRHGQVFADNFPSDTIQSRPLPSTPTHA---TSPDIAGWNSTEDVCGGDEHDPDLFVVLY 128

Query: 266 QFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL-SMEPSSPLGEWTDPALPLENQVWY 324
            F G  ++ L+  + +  R+      G    AK L + +       +  P   LE   WY
Sbjct: 129 DFNGGVENQLTVRKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPVTYVTPFNSLEKHSWY 188

Query: 325 HGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQ 384
           HG ISR  AE LL    + S+LVR+SE+S    S+SL+      H ++S   + K  +  
Sbjct: 189 HGPISRNAAEYLLSSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGSDGKVFVTT 248

Query: 385 NSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
            S  FS++ E+VHH+  +   +      +L YP
Sbjct: 249 ES-KFSTIAELVHHHCKQSDGLIT----TLRYP 276


>UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=5 Tax=Eutheria
           RepID=B0R097_MOUSE
          Length = 161

 Score =  138 bits (347), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 97/157 (61%), Positives = 104/157 (66%)

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
           PE        +   PE     P   ++     +       +    +    +       P 
Sbjct: 5   PEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAGDTQNGWAWTARDPAEMPP 64

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
            P     WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT
Sbjct: 65  FPSLILSWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 124

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM
Sbjct: 125 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 161



 Score = 75.0 bits (182), Expect = 5e-12,   Method: Composition-based stats.
 Identities = 55/142 (38%), Positives = 65/142 (45%), Gaps = 5/142 (3%)

Query: 173 DGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPV 232
           +GA+ EGEG PWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA D +      W    
Sbjct: 1   EGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAGDTQNG----WAWTA 56

Query: 233 GQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAG 292
                 P  P         A    + +        E       S   +    L  + S G
Sbjct: 57  RDPAEMPPFPSLILSWYHGAISRTD-AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 115

Query: 293 NPKSAKPLSMEPSSPLGEWTDP 314
                   + E    LG+ + P
Sbjct: 116 FMHMKLSRTKEHKYVLGQNSPP 137


>UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 domain containing adaptor
           protein B n=1 Tax=Ciona intestinalis RepID=UPI000180BDCA
          Length = 627

 Score =  136 bits (341), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 62/195 (31%), Positives = 100/195 (51%), Gaps = 3/195 (1%)

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
           PW         +P +    R  S   S +P+ +    S  F+  +         +K  +P
Sbjct: 430 PWDTETTLKHGNPHISHS-RSRSYEISSVPQLNRHSKSHSFDNQDPGDDYEHPWDKPSIP 488

Query: 287 PRLSAGNPK-SAKPLSMEPSSPLGEWT-DPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
                   +   + L + PS  + +   DP LPL  Q WYHGAI+R +A   L      S
Sbjct: 489 KVHLESMQRFQHRQLELHPSEAIADKDFDPLLPLTKQGWYHGAITRDEANMRLSREVPGS 548

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           YLVRNSE++ N++SLSL++    +HM +S T++  ++LG+ S PF SVPE++  Y++ +L
Sbjct: 549 YLVRNSESTANNYSLSLRTRSTTIHMVISSTRDGFWILGEFSAPFHSVPEMIAFYSTHRL 608

Query: 405 PIKGAEHMSLLYPVA 419
            I   +++SL YP+ 
Sbjct: 609 KINDTQNISLKYPIT 623


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  133 bits (335), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 80/347 (23%), Positives = 139/347 (40%), Gaps = 29/347 (8%)

Query: 80  SNW--RSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGY 137
           SN+  R  +      + D L+ + L       DPFD     +     SGA   +     +
Sbjct: 53  SNYLARKDSNKGKKNIIDNLKSKVLKNKRTSIDPFDSVTDVQNIKSKSGAKVLMVAFSKF 112

Query: 138 MEPYEAQKMMAEIRGSKETATQPLPL-YDTPYEPEEDGATAEGEGAPWPRESRLPEDDER 196
              Y  Q+   E+  ++      + + +D     E +G        P+    ++ E  + 
Sbjct: 113 K--YTPQR-DDELELNRGDQVLVIEMEHDGWCRGECNGKVG---WFPFNYIQKV-ESSDG 165

Query: 197 PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP 256
              EY  P          +  +D  +I  +    P           D D  +     P  
Sbjct: 166 STSEYADP----------SDVMDKPIISKVRTLYPFKSQSKEELSFDKDIILEIIDKPKD 215

Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLS-MEPSSPLGEWTDPA 315
           +P   D     +   +  L P    +  + P L+ G  K    +S +  + P+ +   P 
Sbjct: 216 DP---DWWRARKSNGEIGLVPRNYVEEIVSPVLTPGPTKPKHSISSLNTNPPIVKDETPD 272

Query: 316 LPLENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
               ++ WYHG +SR++ E LL    K+  YL+RNSE+   DFSLS+K+     H K+  
Sbjct: 273 CIFRDKDWYHGTLSRSECEFLLNEHAKDGEYLIRNSESKPGDFSLSMKAPNRIKHFKILY 332

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPVAI 420
              ++YV+GQ S  FS++ E++ HY +  +   +  + M LLYP+  
Sbjct: 333 -GNNQYVIGQRS--FSNIDELLSHYKNYPIYTTENGQKMHLLYPLNK 376


>UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017925DF
          Length = 555

 Score =  133 bits (335), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 81/318 (25%), Positives = 134/318 (42%), Gaps = 32/318 (10%)

Query: 133 ENDGYMEPYEAQKMMAEIRGSKETATQPLPLY-----------DTPYEPEEDGATAEGEG 181
             D Y E  +    M ++R  +++   P  ++           D    P       EG  
Sbjct: 239 PGDNYQELLDVPFDMPKLRRRQKSEEGPTTVFSTTSSSSSSSSDCAGRPALAPPRPEGLP 298

Query: 182 APWPRESRLPEDDERPPEEYDQPWEWKKER----------ISKAFAV-----DIKVIKDL 226
              P+  R   +    P   + P++  K R          IS  F +            +
Sbjct: 299 FDMPKLRRRQTNAGCGPGGVELPFDMPKLRKRQMDSCARVISLDFEIGSDEEAYSARSGV 358

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
             P    + +    LP     +        +    D S  F     +  +       +L 
Sbjct: 359 RHPADRTKSEQLEELPFDIPKLKKINLHNEDEKKPDRSTLFLNVLPNNCAAVNANNKQLS 418

Query: 287 PRLSAGNPKSAKPLSMEPSSPLG--EWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
                 N  +   LS+    PL   E  D +LPL+ Q WYHG ++R +AE  L   KE +
Sbjct: 419 KTFQNKNQPNRPTLSLCNIKPLNFVEDIDVSLPLDQQCWYHGPMNRLEAEKALHGQKEGT 478

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           YLVR    +K  ++LS+KS++GF+HM++++++E  Y LGQ+  PF ++P+++ HY   KL
Sbjct: 479 YLVR---GNKGSYALSIKSAKGFIHMRITQSEERNY-LGQSDRPFETIPDLIKHYTLNKL 534

Query: 405 PIKGAEHMSLLYPVAIRT 422
           P KGAEH+ L+ P+A + 
Sbjct: 535 PAKGAEHVGLIRPLAHQV 552


>UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4Q6F0_SCHMA
          Length = 1070

 Score =  133 bits (333), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 56/136 (41%), Positives = 85/136 (62%), Gaps = 3/136 (2%)

Query: 289  LSAGNPKS-AKPLSMEPSSPLG-EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
              + NP S  K LS + S P G       LPLE Q W+H  ++R++AE L+R   E S+L
Sbjct: 936  HHSMNPVSKNKLLSSQNSLPKGLPPHLETLPLEEQPWFHPLLTRSEAEELIRNEPEGSFL 995

Query: 347  VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
            VR SET  NDFSL++K    F+HMK++R    +++LG+ S P++SV ++++HYA   +P+
Sbjct: 996  VRPSETCPNDFSLTIKHKS-FLHMKITRNSTGQFILGEYSQPYASVSQMIYHYARTLVPV 1054

Query: 407  KGAEHMSLLYPVAIRT 422
             GA  ++L +PV  R 
Sbjct: 1055 LGAYSVTLTHPVCKRI 1070


>UniRef50_Q5BWZ4 SJCHGC04657 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BWZ4_SCHJA
          Length = 153

 Score =  133 bits (333), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 55/142 (38%), Positives = 86/142 (60%), Gaps = 2/142 (1%)

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT-DPALPLENQVWYHGAISRTDAENLLRLC 340
                 R S  +    K LS + + P G  +    LPLE Q W+H +++R++AE L+R  
Sbjct: 13  SSSGNSRHSMHSVSRNKLLSSQNNLPKGLPSHLEKLPLEEQPWFHPSLTRSEAEELIRNE 72

Query: 341 KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
            E S+LVR SET  NDFSL++K    F+HMK++R    +++LG+ S P+SSV ++++HYA
Sbjct: 73  PEGSFLVRPSETCPNDFSLTIKHK-TFLHMKITRNNAGQFILGEYSQPYSSVSQMIYHYA 131

Query: 401 SRKLPIKGAEHMSLLYPVAIRT 422
              +P+ GA  ++L +PV  R 
Sbjct: 132 RTLVPVLGAYSVTLTHPVFKRV 153


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  130 bits (327), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 52/269 (19%), Positives = 98/269 (36%), Gaps = 20/269 (7%)

Query: 162 PLYDTPY-EPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI 220
           P++D P   P+ + ++   E     +   + E   R P+              +    D 
Sbjct: 22  PVFDQPVASPKSEISSKLAEEIERSKSPLILEVSPRTPDSVQMFR--PTFDTFRPPNSDS 79

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
              +       +    S  S+ +     +  +S      L  +   F G  +  LS  + 
Sbjct: 80  STFRGSQSREDLVACSSMNSVNNVHDMNTVSSSSSSSAPLFVALYDFHGVGEEQLSLRKG 139

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSPL------------GEWTDPALPLENQVWYHGAI 328
           ++ R+           A+  S   +                 +  P   L+   WYHG I
Sbjct: 140 DQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYNSLDKYTWYHGKI 199

Query: 329 SRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP 388
           SR+D+E +L      S+LVR SETS   +++S++      H +++     K  + Q    
Sbjct: 200 SRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQE-VK 258

Query: 389 FSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           F ++ E+VHH++     +       L+YP
Sbjct: 259 FRTLGELVHHHSVHADGLI----CLLMYP 283


>UniRef50_Q0P4A0 Shd protein n=5 Tax=Clupeocephala RepID=Q0P4A0_DANRE
          Length = 299

 Score =  126 bits (317), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 85/250 (34%), Positives = 112/250 (44%), Gaps = 64/250 (25%)

Query: 83  RSTTRLRIIRLRDRLEPR----PLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYM 138
           RS   L  + L +  +P     P+     Y+DPFDV+      +      +  PEN+GYM
Sbjct: 97  RSKILLSSVSLEEPTDPVVPSAPVMGDTGYSDPFDVRLDPRPESAQG---QITPENNGYM 153

Query: 139 EPYEAQKMMAEIRGSKETATQ-----PLPLYDTPYEPEEDGATAEGEGAPWPRESRLPED 193
           EPYEAQK++ E++              + LYDTPYE    G     E     RESRLP+D
Sbjct: 154 EPYEAQKVITELQRRAGGGAGGWGRGEVQLYDTPYEERVPGQPDLPEEG---RESRLPQD 210

Query: 194 DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
           D+RP +EYDQPWEWKKE ISKAFAV  +  +                             
Sbjct: 211 DDRPADEYDQPWEWKKEHISKAFAVQFEGAEW---------------------------- 242

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
                            ++SC    R    R PP  + G+ K  KP   +P S +GE  D
Sbjct: 243 -----------------DRSCSPTERLRCSRAPP--TTGSMKLRKPS--DPHSMIGERVD 281

Query: 314 PALPLENQVW 323
           P+LPLE QV+
Sbjct: 282 PSLPLEKQVY 291


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  123 bits (309), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 8/214 (3%)

Query: 208 KKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQF 267
           KK  I    +    + +       +   ++  S      +     +   EP    +  + 
Sbjct: 346 KKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEED 405

Query: 268 EGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA-LPLENQVWYHG 326
                S     R  K        AG  +S  P S   SS L +    +  PL  Q WYHG
Sbjct: 406 ARSVTSMERKERLSKFESIRHSIAGIIRS--PKSALGSSALSDMISISEKPLAEQDWYHG 463

Query: 327 AISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS 386
           AI R +A+ LL+  K+  +LVR S     ++ LS+ S     H  +    ++ Y      
Sbjct: 464 AIPRIEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYV-DNMYRF--EG 518

Query: 387 PPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             FS++P+++ H+ + K  I     + LL P+  
Sbjct: 519 TGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPK 552


>UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=1 Tax=Tribolium castaneum
           RepID=UPI0001757DDC
          Length = 952

 Score =  123 bits (309), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 37/145 (25%), Positives = 68/145 (46%), Gaps = 9/145 (6%)

Query: 277 PGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL 336
           P       +PPR + G  +      +  +S L +    A  L+   WY G I R +    
Sbjct: 508 PEFASAPAIPPRRAVGTAR------ISTNSTLDKEKSNAFSLQEAEWYWGDIKREEVNEK 561

Query: 337 LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
           L+   + ++LVR++ T   +++L+L+       +K+   K  KY   +    F+SV E++
Sbjct: 562 LKETPDGTFLVRDASTKSGEYTLTLRKGGTNKLIKICH-KNGKYGFTEPY-TFNSVVELI 619

Query: 397 HHYASRKLPIKGAE-HMSLLYPVAI 420
           +H+ +  L    A   + LLYPV++
Sbjct: 620 NHFRNESLSQYNASLDIKLLYPVSM 644



 Score = 78.8 bits (192), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 37/216 (17%), Positives = 79/216 (36%), Gaps = 7/216 (3%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
           ++ ++   +    + +      +  +  S    D   +     +   E  L         
Sbjct: 720 KKEAQPHEIVGLTVNEKLLTQRLKMMQESSEHLDKTLEEKEAYNRTLERELTALKPVVHS 779

Query: 270 PEKSCLSPGR--EEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGA 327
             K      R  +E+G  P +++    ++++       S      D  +  + + W    
Sbjct: 780 LRKERDKYIRWLQERGVSPTKINQVLNRNSEDEEYNTQSGEECDVDSLIHNDERTWLMLD 839

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
             R DAE  L    + ++L+R S TSK  ++LS+  ++   H  +  TK          P
Sbjct: 840 CRRIDAEKYLAGQPDGTFLIRTSSTSK--YALSIACNKMVNHCIIHDTKRGXXXXXXXXP 897

Query: 388 P--FSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
              + ++ ++V HYA+  L I     +  L +P+  
Sbjct: 898 YNIYPTLKDLVLHYATNSLEIHNDSLNTVLAHPLLA 933


>UniRef50_UPI0000D9E9A9 PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=2 Tax=Mammalia RepID=UPI0000D9E9A9
          Length = 239

 Score =  120 bits (300), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 59/153 (38%), Positives = 81/153 (52%), Gaps = 18/153 (11%)

Query: 107 DYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDT 166
           +Y+DPFD Q            P   P +DGYMEPY+AQ++M+E+ G        + LYDT
Sbjct: 105 EYSDPFDAQ------------PHPAPPDDGYMEPYDAQRVMSELPGR------GVQLYDT 146

Query: 167 PYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDL 226
           PYE ++            PR+SR+P++DERP +EYDQPWEWKK+ IS+AFAV     +  
Sbjct: 147 PYEEQDPETADGPPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEWE 206

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPS 259
             P    +L   P       +   PA PL +  
Sbjct: 207 RTPGSAKELRRPPPRSPQPAERVDPALPLEKQP 239


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  119 bits (298), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 5/111 (4%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG +SR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 1   YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 60

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +++   + K  +   S  F+++ E+VHH+++    +      +L YP   R
Sbjct: 61  RINTASDGKLYVSSES-RFNTLAELVHHHST----VADGLITTLHYPAPKR 106


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 33/87 (37%), Positives = 52/87 (59%), Gaps = 2/87 (2%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
            + ++N  WY+G I+R DAE LL    E ++L+R SE+S  DFSLS+K   G  H K+ R
Sbjct: 52  YIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLR 111

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYAS 401
             + K+ L      F+S+ E+V ++ +
Sbjct: 112 DAQSKFFLWV--VKFNSLNELVEYHRT 136


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 7/136 (5%)

Query: 267 FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHG 326
           F   ++     G   +    P LSA  P +    +M  +S        A+ L+   W+HG
Sbjct: 59  FNYVQEKVPVAGSAPQPPQRPVLSAPQPVADNDAAMNHASK------GAVQLKTMPWFHG 112

Query: 327 AISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS 386
            ISR DAE LL   K   +LVR S+    D++L +       + ++ R  E   V   + 
Sbjct: 113 RISREDAEKLLTPPKNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRR-NEKGLVTVDDD 171

Query: 387 PPFSSVPEIVHHYASR 402
             F ++ ++V HY   
Sbjct: 172 EYFDNLIKLVEHYQKE 187


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score =  119 bits (297), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 34/156 (21%), Positives = 63/156 (40%), Gaps = 8/156 (5%)

Query: 272 KSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
            S +          P  +++ NP   +       +   E +  A  L +  WYHG + R 
Sbjct: 190 DSEMEHNSGSNASTPIAVNSPNPNEQQEAIALKKALEWELSLDARELRSHAWYHGPLPRQ 249

Query: 332 DAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR------TKEHKYVLGQN 385
            AE +++  +E  +LVR+  +  +++ LS +S    +H  L++      T   +      
Sbjct: 250 RAEEIVQ--REGDFLVRDCASQPDNYVLSCRSKLAVLHFVLNKLVLQPETVYERVQYQFE 307

Query: 386 SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
              F +VP+++  Y     PI  A    + YP   R
Sbjct: 308 EDAFDTVPDLITFYVGSGKPISAASGALIQYPCNRR 343


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score =  117 bits (293), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 42/192 (21%), Positives = 68/192 (35%), Gaps = 2/192 (1%)

Query: 188 SRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD 247
             +P          D   E ++ +                        +S+      +  
Sbjct: 121 PHIPAGSTAASLLADAA-ELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENL 179

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
           ++ P     +P L  +   F+   ++ LS  + E+ R+     +G    A   S      
Sbjct: 180 LA-PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWV 238

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
              +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+     
Sbjct: 239 PSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 298

Query: 368 MHMKLSRTKEHK 379
            H ++S   + K
Sbjct: 299 YHYRISEDPDGK 310


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  117 bits (293), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 39/162 (24%), Positives = 66/162 (40%), Gaps = 14/162 (8%)

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE- 310
              L +          E   ++ LS  +  + R+           AK LS    S   + 
Sbjct: 3   TPNLTDEEFFVVLYPIESAGRNQLSLRKGCQLRVLRYNGTEEWCEAKVLSTGDPSDNAKC 62

Query: 311 ------------WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
                       +  PA  L    WYHGA+SR  AE LL      S+LVR+SE+ +   S
Sbjct: 63  AVVGSVGWVPSNYITPATSLNMHTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGHLS 122

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           +S++ +    H +++      + +      F ++PE+VHH++
Sbjct: 123 VSVRFNASVYHYRINVDTAGLFYISPEH-RFQTLPELVHHHS 163


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  116 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 39/207 (18%), Positives = 75/207 (36%), Gaps = 7/207 (3%)

Query: 199 EEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEP 258
            E D+P     +RI       I V   +P  P        P        I    +     
Sbjct: 10  GEPDKP----ADRIKLDDPPTIGVGVGVPQIPMPSHAGQPPEQIRPVPQIPESETAGANA 65

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
            +  +   ++      LS  + E   +          +    +         +      +
Sbjct: 66  KIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNYVAKLKSI 125

Query: 319 ENQVWYHGAISRTDAEN--LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           E + WY   I R +AE   LL   +  ++L+R+SE+  ND+SLS++      H ++ +  
Sbjct: 126 EAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLD 185

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRK 403
           E  + + + +  F ++ E+V HY+   
Sbjct: 186 EGGFFIARRT-TFRTLQELVEHYSKDS 211


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  116 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 48/224 (21%), Positives = 81/224 (36%), Gaps = 13/224 (5%)

Query: 196 RPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPL 255
           +P   Y+  + ++         V+       P  P   Q   S       R+        
Sbjct: 8   QPAVGYNGEFFFQPRSDDSDEEVESDAAAAGPSQPGSRQRQPSHRADRYPREPQV----- 62

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
               +      F+G  +  LS  R EK  L  RL           S +       +  P 
Sbjct: 63  --GDVFVGVYNFQGRTEPELSFERGEKLTLLRRLDENWWLMRSQRSGKEGYAPSNYIAPF 120

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM-HMKLSR 374
             +    WYH  ISR  AE LL+   + S+LVR S +S  ++S++L+       H +++ 
Sbjct: 121 KDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGEYSITLRCDGKARTHYRINH 180

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                +V       F++V ++V H+A   +   G       +PV
Sbjct: 181 DARGYFV--AAGKFFATVEQLVAHHA---VVADGLVACLKQHPV 219


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  116 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 40/171 (23%), Positives = 68/171 (39%), Gaps = 14/171 (8%)

Query: 262 DSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE-------WTDP 314
            +   F           +E   R    L   N   +K  ++  +   G        +   
Sbjct: 169 PAVDTFVALYDHTPGCAKEMLLRAGDMLLRVNKDPSKEWTLVENCVTGCQGFVPTSFIAA 228

Query: 315 ALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           +  LE+  W+ G I+R+ AE  L    C   S+L+R SE+S   +SLSL+      H ++
Sbjct: 229 SASLESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRDGDTVRHYRV 288

Query: 373 SRTKEHKYVL-GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
              +   Y L G  +  F+S+PE++  +  RK  +  A    L  P    +
Sbjct: 289 ENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATA----LREPCPKES 335


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  116 bits (290), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 35/129 (27%), Positives = 56/129 (43%), Gaps = 8/129 (6%)

Query: 292 GNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLC--KEASYLVRN 349
              +S      E   P   +      L+ + W+ G I R +AE +L     +  S+L+R+
Sbjct: 92  WFARSKDTAGKEGYIP-SNYVAEYKSLDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRD 150

Query: 350 SETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA 409
           SET+  DFSLS+K      H ++ R ++    + + S  F  + E+V HY          
Sbjct: 151 SETTPGDFSLSVKDQDRVRHYRVRRLEDGSLFVTRRS-TFQILHELVDHYKIE----TDG 205

Query: 410 EHMSLLYPV 418
               LLYP 
Sbjct: 206 LCCKLLYPC 214


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  116 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 53/108 (49%), Gaps = 4/108 (3%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           D +  ++ Q W+HG I RT++  LL+  ++  +L+R S  S  DF LS K+     H K+
Sbjct: 460 DQSKTIKEQTWFHGTIPRTESLRLLQ--QDGDFLLRESNNSLGDFVLSAKADGQVRHFKV 517

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             T    Y    +   F +V  ++ H+  ++ P+    +  LL P+  
Sbjct: 518 QVTDNGMYRFEADQ--FPTVLNLISHHYQKREPVTKRTNCLLLNPICK 563


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  116 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 39/151 (25%), Positives = 66/151 (43%), Gaps = 5/151 (3%)

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISR 330
            +  + P            S  +       S + S    + +   + LE++ WYHGAI R
Sbjct: 115 GRIPVPPNDHSTTLNTGSASGSSLTFQHTSSHDVSCNGSQGSLARVGLESEKWYHGAIQR 174

Query: 331 TDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFS 390
           + AE LL      S+L+R SE+     ++SL+      H ++ R   + Y + + S  F+
Sbjct: 175 SYAEYLLNSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDDSNMYYVIE-SNKFT 233

Query: 391 SVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           SV ++VHH+      +      +LLYP   R
Sbjct: 234 SVSDLVHHHEKHSDGLA----CTLLYPAPKR 260


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 41/191 (21%), Positives = 72/191 (37%), Gaps = 14/191 (7%)

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           LP            +  P+    S        S +    E+    PP        S + +
Sbjct: 45  LPPLASTPPRSPRIVGTPNQTPGSPSRPHFRYSSIP---EDHFSKPPPSPIRTKMSLQDM 101

Query: 301 SMEPSSPL--GEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
           + E    L   E+  P+  + +  W+HG ISR  AE L+R  +   +LVR+S +   +F 
Sbjct: 102 TPEDLRKLLEEEFKLPSEDVRSHAWFHGGISREKAEKLIR--ENGDFLVRDSISKPGNFV 159

Query: 359 LSLKSSQGFMHMKLS------RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           L+++     MH  ++       +             F ++P ++  Y     P+  A   
Sbjct: 160 LTVRWKGVSMHFVVNKVVLKAHSPYASVQYQFEKECFDAIPSLIKFYVGNCRPVSQASGA 219

Query: 413 SLLYPVAIRTL 423
            + +PV  RTL
Sbjct: 220 VIQHPVN-RTL 229


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  115 bits (287), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 37/126 (29%), Positives = 61/126 (48%), Gaps = 12/126 (9%)

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKND----FSLSLK 362
           G +  P   LE + WY G I R DAE LL     ++ S+L+R SE         F+LS++
Sbjct: 115 GNYVAPIQTLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVSNCFALSVR 174

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY--ASRKLPIKGAE---HMSLLYP 417
             +   H ++  T   KY +   S  FS++ E++  Y  +S  L IK  E    + +++ 
Sbjct: 175 DKELIRHYRIKITDSGKYFISL-SKEFSTLNELIEFYKISSDGLKIKLLEPCRKVCIMFK 233

Query: 418 VAIRTL 423
             ++T 
Sbjct: 234 KQVQTF 239


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  115 bits (287), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 8/145 (5%)

Query: 277 PGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP--LENQVWYHGAISRTDAE 334
               + G +P        K+ K L +    P      P++      + WY+G ++R  AE
Sbjct: 188 KENGQVGLVPKNYVTVVQKTHKELGISGPHPSNYDIKPSMDGKFGGKQWYYGKLTRHQAE 247

Query: 335 NLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
            +L +   +  +L+R+SE+  NDFS+SLK+     H K+    +  + +GQ    FS++ 
Sbjct: 248 MVLNQRGVDGDFLIRDSESMPNDFSISLKALYKNKHFKVL-LNDGFFCIGQR--KFSTME 304

Query: 394 EIVHHYASRKLPIKGAEHMSLLYPV 418
           ++V HY   K PI  +EH   LY +
Sbjct: 305 DLVEHYK--KAPIFTSEHGDKLYLI 327


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  115 bits (286), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 8/115 (6%)

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
           SP+G+  +   PLE Q WYHGAI R + + LL   K+  +LVR S+     + LS+  S 
Sbjct: 513 SPVGQEVE--RPLEQQTWYHGAIPRLEVQQLL--TKDGDFLVRKSQEKPG-YVLSVHWSG 567

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
              H  + + K++ Y L  +   F ++P+++  Y + +  +     + L  PV  
Sbjct: 568 ACKHFLV-QNKDNMYCL--DGESFHTIPQLIQQYQTSQQHVTKKSEVVLRRPVLK 619


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  114 bits (285), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 46/218 (21%), Positives = 80/218 (36%), Gaps = 9/218 (4%)

Query: 207 WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQ 266
           W+K  +   F   +          P   L+   +L D D+  SG     P+ S       
Sbjct: 224 WEKGALKDQFCGRMAFPIGELIENP-DPLEGWFALLDADKGKSGYRKFEPDTSEGKVVVA 282

Query: 267 FEGPEKSC-LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPL-GEWTDPALPLENQVWY 324
               +    +     +   L    S G     + L       + G +  P   LE + W+
Sbjct: 283 LYDNDPRGDMELSMRKDDYLLELRSDGAWVQCRHLMTNEEGFVPGTFVAPYKSLEAEPWF 342

Query: 325 HGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
            G I+R  AE LL +   K   +L+R SE++   FSLS+K  +   H ++ +      + 
Sbjct: 343 FGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGENVRHFRVKKVAGGIKLQ 402

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           G  S P   +P ++ ++   +    G    +L  P   
Sbjct: 403 GSPSSPHKDLPSLIKYHKRHR----GGLTTTLKVPCPR 436


>UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4QQ21_SCHMA
          Length = 1124

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 61/251 (24%), Positives = 103/251 (41%), Gaps = 9/251 (3%)

Query: 171  EEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPP 230
            +     +        R + +    +R  +   Q    +  ++S +      +I    +  
Sbjct: 877  DVKSNDSTSAKHKKHRSNMIRSHSQRTADP--QSNLLEGNQLSTSSDHTRCLIPSKYYHR 934

Query: 231  PVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLS 290
             + Q   +    +              P++  SS  F        S    E   +P    
Sbjct: 935  NLSQTVPANPDSNSIWPPVLVQWHRRRPNVAASSENFPDIIDYQGSKRYNENLHIPAEYY 994

Query: 291  AGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNS 350
                      S   SS     T  +  LENQ+W+H  +SR+ AE LL+     S+LVR S
Sbjct: 995  RHQ---KSDFSRHHSSST---TAISEQLENQLWFHRDLSRSHAEKLLKSTPTGSFLVRRS 1048

Query: 351  ETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA 409
            ETSK + SLS+K     +HMK+S+  E   YVLG+ S P+ SV  +++ Y+   LP++G 
Sbjct: 1049 ETSKTELSLSIKRESDVLHMKISQDPETGGYVLGEYSQPYPSVSSMIYRYSRTLLPVRGT 1108

Query: 410  EHMSLLYPVAI 420
              + L +P++ 
Sbjct: 1109 TPVLLRFPISR 1119


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 34/161 (21%), Positives = 67/161 (41%), Gaps = 3/161 (1%)

Query: 243 DGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSM 302
           +   +I+ P    P  ++  +   +E      LS  + E+ ++          +   ++ 
Sbjct: 46  NQPPNINPPMLGGPGVTIFVALYDYEARISEDLSFKKGERLQIINTADGDWWYARSLITN 105

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLS 360
                   +  P    E + WY G + R +AE  L  R     ++L+R +ET+  +FSLS
Sbjct: 106 SEGYIPSTYVAPEKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLS 165

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           ++      H ++ +     Y +     PF+S+ E+V HY  
Sbjct: 166 VRDGDSVKHYRVRKLDTGGYFITTR-APFNSLYELVQHYTK 205


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score =  114 bits (284), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 31/101 (30%), Positives = 54/101 (53%), Gaps = 3/101 (2%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           +  W+H +++ + AE LL    + S+LVR SE+   DF++S+K +    H+K+    +  
Sbjct: 2   SLKWFHSSLNGSQAEELLTPLADGSFLVRPSESKHGDFTISVKCNGKVTHIKIQNDGDSF 61

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM--SLLYPV 418
            ++G    PF ++  +V HY +    IK    +   LLYPV
Sbjct: 62  LLIGSPD-PFPTLESLVSHYRNTPNSIKEKSGVFIELLYPV 101



 Score = 93.1 bits (229), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 5/107 (4%)

Query: 320 NQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            + WYHG+I   +AE  LL   +  SYLVR S++    F L +K + G   + +S  +  
Sbjct: 108 TERWYHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQVIISC-RNK 166

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLP--IKGAEHMSLLYPVAIRTL 423
           KY + ++ P F+S+ E++ +Y        +K    + L  P    + 
Sbjct: 167 KYEI-KSGPSFASLQELIEYYVMNPKLHDVKDQSPIKLREPFQSTSF 212


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score =  114 bits (284), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 37/195 (18%), Positives = 73/195 (37%), Gaps = 18/195 (9%)

Query: 232 VGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSA 291
           + QL    +    +          P  ++EDS  +  G   +       +      + + 
Sbjct: 159 LKQLTFDETSTIYEELRPRSKCNSPHWAIEDSRMEGYGSSNATTPLATAQPSPSEQQEAI 218

Query: 292 GNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSE 351
              K+ +           E +  A  L +  WYHGA+ R  AE +++  +E  +LVR+  
Sbjct: 219 ALKKALE----------WELSLDARELRSHAWYHGALPRQRAEEIVQ--REGDFLVRDCA 266

Query: 352 TSKNDFSLSLKSSQGFMHMKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLP 405
           +  +++ LS +S    +H  L++      T   +         F +VP+++  Y     P
Sbjct: 267 SQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKP 326

Query: 406 IKGAEHMSLLYPVAI 420
           I  A    + +P   
Sbjct: 327 ISSASGALIQFPCNR 341


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score =  114 bits (284), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 9/112 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L++  WYHG + R   E LL   ++  +LVR+S ++  D+ L+     G MH K+ R   
Sbjct: 19  LKSHAWYHGPLGREAGEALLE--RDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKIIRVVL 76

Query: 376 ----KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                  + +       F +VP ++  +   + PI  A    + +P+  RTL
Sbjct: 77  RPKQGYSRELFQFEEDRFDNVPALIRFHVGSRRPISQASSAVIFHPI-TRTL 127


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score =  113 bits (283), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 4/102 (3%)

Query: 319 ENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           E+  WYHG +SR   ENLL+     + S+LVR S +S  DF LS+  +    H ++ R  
Sbjct: 5   EDIFWYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHS 64

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           E  +     +     +  ++ HY + K  +  +E +SL  PV
Sbjct: 65  EDAFFSIDENTKIHGLESLIEHYVNTKGIL--SEGLSLTVPV 104



 Score = 76.9 bits (187), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 35/154 (22%), Positives = 64/154 (41%), Gaps = 6/154 (3%)

Query: 249 SGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPL 308
           S        P  E +S   +   K+ LS       R        +  + K   +E +  L
Sbjct: 213 SRNTETGAVPLHEAASRGHKDVVKALLSLNAPVNPRDKDNQ-LPSHLARKNGFIECAEIL 271

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQG 366
             +  PA       WYHG + R +AE  ++    K+ ++LVR S+ +K +  L+L +   
Sbjct: 272 ENYQCPAPKTHRSYWYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTLINESL 330

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           F +  + +  +  Y+   N P   S+  I+ +Y+
Sbjct: 331 FYNYIIRKQDD--YLFIDNGPYLESLEHIIEYYS 362


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  113 bits (283), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 33/121 (27%), Positives = 56/121 (46%), Gaps = 5/121 (4%)

Query: 303 EPSSPLGEWTDPALPLE--NQVWYHGAISRTDAENL-LRLCKEASYLVRNSETSKNDFSL 359
           E +    E   P +  E   + W+HG +S  +AE L L   K  S+LVR S++   DF L
Sbjct: 89  EKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVL 148

Query: 360 SLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           S+++     H+ + R ++ KY +G     F ++ E++ HY    +       + L  P  
Sbjct: 149 SVRTDDKVTHVMI-RWQDKKYDVGG-GESFGTLSELIDHYKRNPMVETCGTVVHLRQPFN 206

Query: 420 I 420
            
Sbjct: 207 A 207



 Score =  101 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 53/104 (50%), Gaps = 4/104 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR-KLPIKGAEHMSLLYPVA 419
           +   + G     F+++PE+V +Y    +L  K  + + L  P+ 
Sbjct: 61  DFFDLYG--GEKFATLPELVQYYMENGELKEKNGQAIELKQPLI 102


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  113 bits (283), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 50/237 (21%), Positives = 84/237 (35%), Gaps = 7/237 (2%)

Query: 167 PYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDL 226
           P  P+  G  +  E  P       P            P   K  R   A      V    
Sbjct: 193 PTGPKPSGRLSAPEAPPAASLPPKPAALL--AAVMTGPGSPKAMR--HAMEAPPMVTAPK 248

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
           P          S + P      S P +P   P  +     F+    +       +   + 
Sbjct: 249 PAALLASMRGPSGASPTSPAPASSPVAPAVVPERKQVRVMFDYIATAAGDLTIHKDEMIT 308

Query: 287 PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASY 345
                 N   A+    E       +      LE + W+ G ISR +A  +L++ K E  +
Sbjct: 309 ILEERPNWWKAQNKHGEVGFVPSNYLCRIQGLEGEPWFRGRISRAEAAAMLQITKQEGCF 368

Query: 346 LVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
           LVR SET   +++LSL  ++G  H ++    E +Y + +N   F S+P+++ ++   
Sbjct: 369 LVRESETQPGEYTLSLSHNEGVRHYRIQHI-EGQYFVNENH-RFDSIPQLIEYHKLN 423


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  113 bits (283), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 8/143 (5%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F+      LS  R +  ++       N   A     E +   G      + ++   
Sbjct: 5   AKYDFKATADDELSFKRGDILKVLNEECDQNWYKA-----ELNGKDGFIPKNYIEMKPHP 59

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+ G I R  AE +L +   + ++L+R SE++  DFSLS+K      H K+ R    KY 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYASRKL 404
           L      F+S+ E+V ++ S  +
Sbjct: 120 LWV--VKFNSLNELVDYHRSTSV 140


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 39/169 (23%), Positives = 69/169 (40%), Gaps = 17/169 (10%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F+      LS  R +  ++       N   A     E +   G      + ++   
Sbjct: 5   AKYDFKATADDELSFKRGDILKVLNEECDQNWYKA-----ELNGKDGFIPKNYIEMKPHP 59

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+ G I R  AE +L +   + ++L+R SE++  DFSLS+K      H K+ R    KY 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL-------LYPVAIRTL 423
           L      F+S+ E+V ++ S    +   + + L         P  ++ L
Sbjct: 120 LWV--VKFNSLNELVDYHRSTS--VSRNQQIFLRDIEQVPQQPTYVQAL 164


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 33/162 (20%), Positives = 67/162 (41%), Gaps = 7/162 (4%)

Query: 260 LEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLE 319
           +  +   ++      LS  + E   +          +    + +       +      +E
Sbjct: 84  IFVALYDYDARTDEDLSFKKGEHLDILNDTQGDWWFARSKSTKQEGYIPSNYVAKLKSIE 143

Query: 320 NQVWYHGAISRTDAEN--LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
            + WY G I R +AE   LL   +  ++LVR+SE+ +NDFSLS++      H ++ +  E
Sbjct: 144 AEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFSLSVRDGDTVKHYRIRQLDE 203

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
             + + + +  F ++ E+V HY +          ++L  P  
Sbjct: 204 GGFFIARRT-TFRTLQELVDHYGNE----ADGLCVNLRKPCV 240


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 8/126 (6%)

Query: 296 SAKPLSMEPSSPLGEWTDPALP--LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSET 352
           S  P      +P   +T P+       + WY+G ++R  AE  L     E  +L+R+SE+
Sbjct: 256 SDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSES 315

Query: 353 SKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           S +DFS+SLK+S    H K+ +  ++ Y +GQ    F ++ E+V HY   K PI  +EH 
Sbjct: 316 SPSDFSVSLKASGKNKHFKV-QLVDNVYCIGQR--RFHTMDELVEHYK--KAPIFTSEHG 370

Query: 413 SLLYPV 418
             LY V
Sbjct: 371 EKLYLV 376


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 42/214 (19%), Positives = 83/214 (38%), Gaps = 15/214 (7%)

Query: 202 DQPWEWKKERISKAFAVDIKVIKDLPWPPPV--GQLDSSPSLPDGDRDISGPASPLPEP- 258
           +Q  +  K++  K      +  +       +   Q          ++   GPA+P  EP 
Sbjct: 47  EQAQQALKDQDEKRMEKKKRHQQQRKEEQRLLKQQQKEEKQRIKEEKRRKGPATPKQEPV 106

Query: 259 -------SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPL--G 309
                  +   +   ++   KS L   ++    +       N   A+P+           
Sbjct: 107 KCFIPINTKVTAVYDYQPKSKSELQL-KQGDVFVITNSENENWWEAQPVGNSDIVGWVPS 165

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +      L+++ +YHG I RT AE  L      S+LVR S+++  + ++SL+      H
Sbjct: 166 NYVVKLNSLDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEHTISLRCDGKVFH 225

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
            ++SRT +  ++       FS+V ++V  Y  + 
Sbjct: 226 YRISRTDKGVFIAADR--VFSTVQDLVKFYHQQS 257


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  111 bits (277), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 38/202 (18%), Positives = 76/202 (37%), Gaps = 17/202 (8%)

Query: 231 PVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLS 290
           P G+L  +  +  G    +   + +P  +  +    F    K  L   + +   +  R  
Sbjct: 5   PTGKLIDTGPVTRGPSYENHSLTTIPNGTTCEGVFDFNTGNKGDLPFKKGDTLVVIQRTR 64

Query: 291 AGNPKSAKPLSMEPSSPLGEWTDPA-----------LPLENQVWYHGAISRTDAENLLRL 339
             N   A+    E       +   +           + L    W+HG I+R+DAE+LL  
Sbjct: 65  DPNWYRAQNSKGESGMVPLNYITQSNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLLTP 124

Query: 340 CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
            K+  +LVR S     D+++ +  +    H ++   K++K  +      F ++ ++V HY
Sbjct: 125 RKDGLFLVRESTNYPGDYTMCVSFAGEVEHYRVIF-KDNKVTI-DEEEYFENLTKLVEHY 182

Query: 400 ASRKLPIKGAEHMSLLYPVAIR 421
                        +L  P+  +
Sbjct: 183 ERD----ADGLVCTLTQPLIKK 200


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score =  111 bits (276), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 33/107 (30%), Positives = 58/107 (54%), Gaps = 6/107 (5%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
            L+ ++W+HG++SR +AE++L   ++  +LVR S+ S   + L+  ++    H+ L    
Sbjct: 340 QLKQEIWFHGSVSRAEAESML--TRDGDFLVRESQGSPGQYVLTGMNNNTPKHLLLI-DP 396

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM-SLLYPVAIRT 422
           E   V+      F SV  +V+H+    LPI  A+ +  L YP+  RT
Sbjct: 397 EG--VVRTKDRVFDSVSHLVNHHCDNVLPIISADSVLVLRYPIPRRT 441


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  110 bits (275), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 50/239 (20%), Positives = 91/239 (38%), Gaps = 14/239 (5%)

Query: 183 PWPRESRLPEDDERPPEEY-DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSL 241
           P P+E     D     ++Y D   E ++ R  +A       + D+       + +    +
Sbjct: 75  PSPKEEGAILDLLSKQKQYRDASREIQELRCQEAKLSTQYSMLDVKLSEMGDEDNLPLGI 134

Query: 242 PDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLS 301
              +   +G  S     S   +S+     E+         K     ++ AG+  S +P +
Sbjct: 135 IFPEGGGTGTLSTRTIQSPNLNSSTDSTTEQKSKRSNMANKMTKIFKVRAGHDSSHEPSN 194

Query: 302 MEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSL 361
            +P+          L LE + +YHGA+ R + E LL    +  ++VR    +   + LS 
Sbjct: 195 NQPTE---------LRLEEEEFYHGALPRKETEALL--VNDGDFVVREKSDAWGRYVLSA 243

Query: 362 KSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           K +    H  +    E+ Y L      F +V E++    + + P+  A    LL PV  
Sbjct: 244 KHASKVRHFPIQINDENMYRL--EGDAFQTVGELIRFQLNSRQPVTKASQAILLKPVCR 300


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score =  110 bits (275), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 26/100 (26%), Positives = 52/100 (52%), Gaps = 2/100 (2%)

Query: 305 SSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSS 364
           ++ + +      P  ++ W+H  +SR  AENLL   +   +++R S++S  DFS+S++  
Sbjct: 14  NNSVSKPRHKLNPFSSKRWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHE 73

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
               H K+ R  +  Y L   +  F S+ ++V +Y +  +
Sbjct: 74  DDVQHFKVMRDNKGNYFLW--TEKFPSLNKLVDYYRTNSI 111


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 48/242 (19%), Positives = 88/242 (36%), Gaps = 14/242 (5%)

Query: 169 EPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPW 228
           E +        E  P P  + +      P      P    K       ++ +        
Sbjct: 8   ENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSG 67

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
             P G   SS S+         PA      ++  +   +E      LS  + E+ ++   
Sbjct: 68  VTPFGGASSSFSVVPSSY----PAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIIN- 122

Query: 289 LSAGNPKSAKPLSMEPSSPL-GEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASY 345
            + G+   A+ ++   +  +   +  PA  ++ + WY G + R DAE LL         +
Sbjct: 123 NTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIF 182

Query: 346 LVRNSETSKNDFSLSLKS-----SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           LVR SET+K  +SLS++           H K+ +     Y +   +  F ++ ++V HY 
Sbjct: 183 LVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQ-FDTLQKLVKHYT 241

Query: 401 SR 402
             
Sbjct: 242 EH 243


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 40/187 (21%), Positives = 71/187 (37%), Gaps = 13/187 (6%)

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
           P+ P +       ++ +    +  P           +   ++      LS    +K ++ 
Sbjct: 14  PYLPCLSTEADKSTVIENPGALCSP-QSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVL 72

Query: 287 PRLSAGNP--------KSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL- 337
             L  G          +      ++   P   +      L+ + W+ GAI R+DAE  L 
Sbjct: 73  DTLHEGWWFARHLEKRRDGSSQQLQGYIP-SNYVAEDRSLQAEPWFFGAIGRSDAEKQLL 131

Query: 338 -RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
               K  S+L+R SE+ K +FSLS+       H ++ R  E  + L +    FS++ E V
Sbjct: 132 YSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR-RIFSTLNEFV 190

Query: 397 HHYASRK 403
            HY    
Sbjct: 191 SHYTKTS 197


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 30/99 (30%), Positives = 49/99 (49%), Gaps = 3/99 (3%)

Query: 323 WYHGAISRTDAENL-LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+HG +S  +AE L L   K  S+LVR S++   DF LS+++     H+ + R  E+KY 
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRTEDKVTHVMI-RWHENKYD 116

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           +G     F ++ E++ HY    +       + L  P   
Sbjct: 117 VGG-GQKFGTLCELIEHYKRNPMVEICGTVVHLRQPFNA 154


>UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3 n=43
           Tax=Euteleostomi RepID=BCAR3_HUMAN
          Length = 825

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 42/244 (17%), Positives = 78/244 (31%), Gaps = 10/244 (4%)

Query: 185 PRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLD--SSPSLP 242
           P   + P            P    +    +  ++   + +    PPP+   D  S     
Sbjct: 14  PVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTL 73

Query: 243 DGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSM 302
              +     +    +   E       G   +   P   +      + S       +    
Sbjct: 74  PHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEK 133

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
                  E    +  L +  WYHG I R  +ENL++  ++  +LVR+S +S  +F L+ +
Sbjct: 134 LKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQ 191

Query: 363 SSQGFMHMKLSRT------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
                 H K++RT         +         F S+P +V  Y   + PI       +  
Sbjct: 192 WKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQ 251

Query: 417 PVAI 420
           P+  
Sbjct: 252 PINR 255


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 41/111 (36%), Positives = 60/111 (54%), Gaps = 8/111 (7%)

Query: 309 GEWTDPALP--LENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQ 365
            ++  P+L        WY+G ++R  AE  L     E  +L+R+SE+S NDFS+SLK+  
Sbjct: 69  CDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQG 128

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
              H K+ + KE  Y +GQ    FS++ E+V HY   K PI  +E    LY
Sbjct: 129 KNKHFKV-QLKETVYCIGQR--KFSTMEELVEHYK--KAPIFTSEQGEKLY 174


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 34/139 (24%), Positives = 57/139 (41%), Gaps = 21/139 (15%)

Query: 302 MEPSSPLGEWTDPALPLE---------NQVWYHGAISRTDAENLL-RLCKEASYLVRNSE 351
           ME    L E     + L+         ++ W+HG +S  +AE LL    K  S+LVR S+
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKGKNGSFLVRESQ 141

Query: 352 TSKNDFSLSLKSSQ----------GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +   DF LS+++               H+ +    + KY +G     F S+ ++V HY  
Sbjct: 142 SHPGDFVLSVRTGDDKTDSSDSKPKVTHVMIRCQHDLKYDVGG-GEKFDSLTDLVEHYKK 200

Query: 402 RKLPIKGAEHMSLLYPVAI 420
             +       + L  P+  
Sbjct: 201 NPMVETLGTVLQLKQPLNT 219



 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 5/105 (4%)

Query: 318 LENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  I+  +AENLL     + S+L R S+++  DF+LS++ +    H+K+  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
           ++  + G     F+++ E+V +Y     +L  K  + + L YP+ 
Sbjct: 61  DYYDLYG--GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 35/167 (20%), Positives = 68/167 (40%), Gaps = 12/167 (7%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
           +L  +   +E   +  LS  + EK ++         ++    + E       +  P   +
Sbjct: 85  TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSI 144

Query: 319 ENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKS-----SQGFMHMK 371
           + + WY G + R DAE  L        ++L+R SET+K  +SLS++           H K
Sbjct: 145 QAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK 204

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           + +     Y +   +  F ++ ++V HY+ R   +       L+ P 
Sbjct: 205 IRKLDNGGYYITTRAQ-FETLQQLVQHYSERAAGL----CCRLVVPC 246


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 25/89 (28%), Positives = 48/89 (53%), Gaps = 2/89 (2%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           + ++   W+H  +SR  AENLL   +   +++R S++S  DFS+S++      H K+ R 
Sbjct: 51  IDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRD 110

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
            +  Y L   +  F S+ ++V +Y +  +
Sbjct: 111 NKGNYFLW--TEKFPSLNKLVDYYRTNSI 137


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 30/106 (28%), Positives = 59/106 (55%), Gaps = 7/106 (6%)

Query: 317 PLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P E ++W+HG IS+ +A NLL    +  S+LVR S+ +  D+SL  ++++     K+  T
Sbjct: 345 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 404

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
             +++++G     ++S+ +I+ HY   ++     E   L  PV ++
Sbjct: 405 PNNQFMMG--GRYYNSIGDIIDHYRKEQI----VEGYYLKEPVPMQ 444



 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 39/119 (32%), Positives = 56/119 (47%), Gaps = 11/119 (9%)

Query: 306 SPLGEWTDPALPLEN---QVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSL 361
            P  E  + A+PL       WYHG + RT AE  LR   K  SYL+R S+     F LS 
Sbjct: 161 GPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSF 220

Query: 362 KSSQGFM-HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
            S    + H ++       Y+       FSS+ +++ +Y+     +KG +   LLYPVA
Sbjct: 221 LSQMNVVNHFRIIAMCGDYYI---GGRRFSSLSDLIGYYSHVSCLLKGEK---LLYPVA 273


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 61/290 (21%), Positives = 103/290 (35%), Gaps = 24/290 (8%)

Query: 144 QKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQ 203
           Q++  +    +E A Q +   +   +        E E      E     + +R  E Y  
Sbjct: 142 QEVARQEVARQEVARQEVARQEVARQEVARQEKREAEERRRAEEEVRRVEQKRKQEIYMD 201

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
             E ++ER  + +   ++  K             S +    D         L    +   
Sbjct: 202 LREVREERDDQHWQDSLRKSKAADLRRR------SIAKQTRDDHRRQSVKALERGRVAAV 255

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP---LGEWTDPALPLEN 320
           +  F G     + P + +   L       NPK     ++  SS    +  + +  LP   
Sbjct: 256 TKAFGG--DRPVLPPKPKPRNLTVTSDTLNPKQGLQRTLSTSSREHIIRWFQEEQLPFRA 313

Query: 321 ---------QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
                      W+HG ISR +AE+LL   +   +LVR SE     + LS +    F H  
Sbjct: 314 GFQKDQSRIASWFHGIISRQEAEDLLSEGEPGHFLVRVSERILG-YVLSYRCKDEFKHFL 372

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +  T E  Y+L  +   F+S+ E+V  +    + + G E   LL P   R
Sbjct: 373 IDAT-EGCYMLLGHQIRFTSLAELVEFHKGEPITMSGGEQ--LLQPCGQR 419


>UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, partial n=1 Tax=Tribolium
           castaneum RepID=UPI000175898D
          Length = 876

 Score =  108 bits (268), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 27/117 (23%), Positives = 53/117 (45%), Gaps = 8/117 (6%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  +  L +  WYHGAI R+ AE+++R  +E  +LVR+  +   ++ L+ ++    +H
Sbjct: 163 ELSLDSRDLRSHAWYHGAIPRSRAEDIVR--EEGGFLVRDCTSQPGNYVLTCRTKTQPLH 220

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             +++      T             F +VP+++  Y     PI  A    + +P   
Sbjct: 221 FVINKIILQPDTVYEHVQFQFEEDAFDTVPDLITFYVGSGKPITAASGARIQFPKNR 277


>UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio RepID=A2BDR6_DANRE
          Length = 635

 Score =  108 bits (268), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 37/144 (25%), Positives = 66/144 (45%), Gaps = 13/144 (9%)

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
           + S G  + + P          E    +  L +  WYHG I    +E+L++  +E  +L+
Sbjct: 15  KFSKGTHQPSSPPDKLKQELEKELKLSSCNLSSHGWYHGRIPWEVSESLVQ--QEGDFLI 72

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRT--------KEHKYVLGQNSPPFSSVPEIVHHY 399
           R+S +S  D+ L+ + +Q  +H  +++            +Y+L + +  F SVP +VH Y
Sbjct: 73  RDSLSSIGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEET--FYSVPALVHSY 130

Query: 400 ASRKLPIKGAEHMSLLYPVAIRTL 423
              K P+       +  PV  RTL
Sbjct: 131 VGNKRPLTKKSAAYIYSPVN-RTL 153


>UniRef50_UPI000186F2CC Phosphatidylinositol 3-kinase regulatory subunit alpha, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186F2CC
          Length = 726

 Score =  107 bits (267), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 35/138 (25%), Positives = 60/138 (43%), Gaps = 10/138 (7%)

Query: 286 PPRLSA--GNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEA 343
           PPR  +  G       L +E      +       L++  WY G I+R +    L    + 
Sbjct: 289 PPRKVSRPGPHPYRDDLELE-----RDRDSAQQQLKDAEWYWGDITREEVNEKLMNTPDG 343

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
           ++LVRN+     +++L+L+       +K+   K  KY   +    F+SV E+V  Y +  
Sbjct: 344 TFLVRNASNKGGEYTLTLRKGGTNKLIKICH-KNGKYGFSEPY-KFNSVVELVKFYKTSS 401

Query: 404 LPIKGAE-HMSLLYPVAI 420
           L    +   + LLYPV+ 
Sbjct: 402 LAQYNSTLDIKLLYPVSR 419



 Score = 87.3 bits (214), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 34/129 (26%), Positives = 59/129 (45%), Gaps = 8/129 (6%)

Query: 299 PLSMEPSSPLGEWTDP---ALPLENQ-VWYHGAISRTDAENLLRLCKEASYLVRNSETSK 354
           P S+ P       TD    ++P +N+ +W     SR  A  LL    E ++LVR S +  
Sbjct: 583 PESLTPWGLRELETDENLKSMPHQNEYLWNLPECSRAQAATLLESKPEGTFLVRPSSS-- 640

Query: 355 NDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMS 413
             ++LS+  +    H  + +T +  +   +    + S+ ++V HYA+  L     E   +
Sbjct: 641 GQYALSIVCNGVINHCIIYQT-DRGFGFAEPYNIYPSLKQLVLHYANNSLEEHNEELKTT 699

Query: 414 LLYPVAIRT 422
           L+YPV   T
Sbjct: 700 LMYPVFALT 708


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  107 bits (267), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 36/183 (19%), Positives = 65/183 (35%), Gaps = 25/183 (13%)

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT--- 312
            +    +++  F G  K  L   + +   +       N    +  +         +    
Sbjct: 19  TKGMKCEAAYDFNGASKEDLPFKKGDILTIENPTEDPNWWLVRDKTGRTGMIPANYVELI 78

Query: 313 ------------DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
                       D +  L    W+HG ISR  AE+LL   ++  +LVR S     D++L 
Sbjct: 79  GSDTKKTGTLPRDASGQLIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLC 138

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS--LLYPV 418
           +       H ++    ++  +       FSS+ E+V HY       K A+ +   L  PV
Sbjct: 139 VCFQDQVDHYRMQ--GKNGKLTIDEEVYFSSLEELVQHYE------KDADGLCTRLRKPV 190

Query: 419 AIR 421
             +
Sbjct: 191 VKQ 193


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  107 bits (267), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 5/105 (4%)

Query: 318 LENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  I+  +AENLL     + S+L R S+++  DF+LS++ +    H+K+  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
           ++  + G     F+++ E+V +Y     +L  K  + + L YP+ 
Sbjct: 61  DYYDLYG--GEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103



 Score =  104 bits (258), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 36/139 (25%), Positives = 59/139 (42%), Gaps = 22/139 (15%)

Query: 302 MEPSSPLGEWTDPALPLE---------NQVWYHGAISRTDAENLL-RLCKEASYLVRNSE 351
           ME    L E     + L+         ++ W+HG +S  +AE LL    K  S+LVR S+
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQ 141

Query: 352 TSKNDFSLSLKSSQ----------GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +   DF LS+++               H+ + R +E KY +G     F S+ ++V HY  
Sbjct: 142 SHPGDFVLSVRTGDDKGESNDGKSKVTHVMI-RCQELKYDVGG-GERFDSLTDLVEHYKK 199

Query: 402 RKLPIKGAEHMSLLYPVAI 420
             +       + L  P+  
Sbjct: 200 NPMVETLGTVLQLKQPLNT 218


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  107 bits (267), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 1/86 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           EN  W+HG ISR DAE +LR    +  +LVR S +S+ D+ LS+      +H  + R  +
Sbjct: 5   ENLCWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGD 64

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRK 403
             +    +  P   +  ++ HY   K
Sbjct: 65  DAFFSIHDHTPIHGLDSLIEHYQKDK 90



 Score = 62.2 bits (149), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 31/145 (21%), Positives = 49/145 (33%), Gaps = 47/145 (32%)

Query: 313 DPALPLENQV-WYHGAISRTDAENLLRL-------------------------------- 339
           +P  PL ++  WYHG + RT A + L+                                 
Sbjct: 273 EPQRPLTHRDLWYHGTLERTAAVDYLKDFAVKLLPNLAHRQQQQQPDRDGNKENGECLDG 332

Query: 340 ---CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
                  +YLVR S     D  L++       H  + R ++  Y+     P  +S+  ++
Sbjct: 333 LEQSTSGTYLVRYSAKQNVD-VLTMLYDNEPKHFIIQRQQDWLYI--DEGPYMNSLEHLI 389

Query: 397 HHYAS--RKLPIKGAEHMSLLYPVA 419
            HY      LPI       L +PV 
Sbjct: 390 EHYTRFSDGLPIN------LRFPVT 408


>UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID=Q7PSB5_ANOGA
          Length = 940

 Score =  107 bits (266), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 24/117 (20%), Positives = 50/117 (42%), Gaps = 8/117 (6%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  +  L +  WYHG I R  AE +++  KE  +LVR+  +   ++ L+ ++    +H
Sbjct: 227 ELSLDSRDLRSHAWYHGPIPRQRAEEIVQ--KEGDFLVRDCVSQPGNYVLTCRTKGPTLH 284

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             +++      T   +         + +VP+++  Y      I  A    + +P   
Sbjct: 285 FVINKLLLQPETVYERVQYQFEDDAYDTVPDLITFYVGSGKSISVASGARIQFPCNR 341


>UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Fragment)
           n=8 Tax=Euteleostomi RepID=Q5T4P3_HUMAN
          Length = 206

 Score =  107 bits (266), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 32/119 (26%), Positives = 61/119 (51%), Gaps = 4/119 (3%)

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLK 362
            S+      D ++ L++  WY G ISR +  + LR   + ++LVR++ T  + D++L+L+
Sbjct: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR 105

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
                  +K+   ++ KY        F+SV E+++HY    L     +  + L+YPV+ 
Sbjct: 106 KGGNNKLIKIYH-RDGKYGFSDP-LTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSR 162


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 39/166 (23%), Positives = 68/166 (40%), Gaps = 12/166 (7%)

Query: 260 LEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKP-------LSMEPSSPLGEWT 312
               S+  E   K   +    +   +  R S G+ +  K         S +         
Sbjct: 653 RRSDSSDLENQGKHTNNEEVSQDNEVRGRKSKGDQRKGKQEIEVIKYKSKKGDIAKESRK 712

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMK 371
                LE+Q WYHG +SR D E LL   K   +LVR ++    +   LS+   +  +H+ 
Sbjct: 713 QQRKELEDQHWYHGLLSREDIEKLL--VKNGDFLVRVTDNQGVHQIVLSIHVGERNIHLT 770

Query: 372 LSRTKEHKYVLG--QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
           ++ T++  + L   +  P F S+ ++V +Y   K+ IK A    + 
Sbjct: 771 IAVTEDGHFQLSVLRRGPRFPSIYDLVQYYKMHKIKIKDASGKDIR 816


>UniRef50_UPI000052380F PREDICTED: similar to phosphoinositide-3-kinase, regulatory subunit
           3 (p55, gamma) n=1 Tax=Ciona intestinalis
           RepID=UPI000052380F
          Length = 552

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 41/194 (21%), Positives = 79/194 (40%), Gaps = 8/194 (4%)

Query: 234 QLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQF----EGPEKSCLSPGREEKGRLPPRL 289
           Q D +  +P    +      P P P             +  E   + P R      P   
Sbjct: 68  QTDETGYIPAEYVEYVQTVVPRPAPRERPLLPPVPEVVDEAEVPPVIPPRCGSDSRPQVN 127

Query: 290 SAGNPKSAK-PLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVR 348
           S   P      +S   +SP       +  L++Q WY G+++R +    L   ++ ++LVR
Sbjct: 128 SNYVPVPINVNVSNGSNSPRPHRPSLSQSLQDQEWYWGSVTREEVNAQLSDEQDGTFLVR 187

Query: 349 NSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG 408
           NS  S  +++L+L+       +++  ++   Y   +    F+SV ++V+HY +  L    
Sbjct: 188 NSANSDREYTLTLRKGGSNKLIRIM-SRNGMYGFAEP-LIFNSVIQLVNHYRNEPLTRYN 245

Query: 409 AE-HMSLLYPVAIR 421
            +  ++L YP   +
Sbjct: 246 PDLDITLRYPAPKQ 259



 Score = 73.8 bits (179), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 17/82 (20%), Positives = 36/82 (43%), Gaps = 2/82 (2%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+     R +A+ +LR     ++L+R        ++ SL ++    H  + +T +  Y  
Sbjct: 452 WFFPRYGRREADEVLRGTPNGTFLIRE-RNGPPPYACSLVANGKVHHCLIEQTDDG-YGF 509

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
            +      ++ ++V HYA   L
Sbjct: 510 AEPFNLHLTLSDLVLHYAHNSL 531


>UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SMI9_TETNG
          Length = 609

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 9/112 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG + R  AE LL   +   +LVR+S ++  D+ L+       MH K+ R   
Sbjct: 16  LSSHAWYHGPLRREAAEALLE--RNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVL 73

Query: 376 ----KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                  + +       F ++P ++  Y   + PI  A    + +P+  RTL
Sbjct: 74  RPKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQASGAVISHPI-TRTL 124


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 44/237 (18%), Positives = 84/237 (35%), Gaps = 12/237 (5%)

Query: 171 EEDGATAEGEGAPWPRESRLPED--DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPW 228
           E  G           + S +P+      P   + QP       +   +A +    ++L +
Sbjct: 169 ERPGQPGYFPSNYVVKSSSMPQSCPSSMPNTSHVQPASDCISVVRTLYAFNSGNPEELAF 228

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
                         D +  ++  +  L      +     +G +       +      P  
Sbjct: 229 EQDEMLDIIEQPPDDPEWWLARNSEGLTGLVPMNYVEVVDGAQPVSSGNIQNYDRVCPQH 288

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE-ASYLV 347
               N  +        ++ +G     A  + ++ WY G + R DAE  L+   +   +LV
Sbjct: 289 NDIENMHA-------QNTAIGGNDGAADGIHSRDWYFGNMKRADAEQRLQDRADNGEFLV 341

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           R SETS  D+S+S+K      H K++      + +GQ    F S+  ++ HY S  +
Sbjct: 342 RGSETSSGDYSISMKMPGRIRHFKVNTLPNGVFGIGQR--KFDSMDALLEHYKSAPI 396


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 30/101 (29%), Positives = 50/101 (49%), Gaps = 7/101 (6%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           +E + WYHG ISR +A  LL+  K   +LVR S   +  ++L++K  +G  H  +   +E
Sbjct: 512 VEEEPWYHGEISRQEATGLLK--KMGDFLVRYSADKE-HYTLTVK-MEGIKHFIIQHNEE 567

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                     P+ S+P ++ H+   +LP+       L  PV
Sbjct: 568 GFRF---EGDPYPSIPMLIDHHFKNRLPVTRKSQAILRQPV 605


>UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepID=Q05DQ0_HUMAN
          Length = 283

 Score =  106 bits (264), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 32/119 (26%), Positives = 61/119 (51%), Gaps = 4/119 (3%)

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLK 362
            S+      D ++ L++  WY G ISR +  + LR   + ++LVR++ T  + D++L+L+
Sbjct: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR 105

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
                  +K+   ++ KY        F+SV E+++HY    L     +  + L+YPV+ 
Sbjct: 106 KGGNNKLIKIYH-RDGKYGFSDP-LTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSR 162


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 35/143 (24%), Positives = 62/143 (43%), Gaps = 8/143 (5%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F+  E   L+  + +  ++       N   A+   +E   P        + ++   
Sbjct: 5   ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKN-----YIRVKPHP 59

Query: 323 WYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY G ISR  AE +L       ++L+R SE+S  +FS+S+       H K+ R    KY 
Sbjct: 60  WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYASRKL 404
           L +    F+S+ E+V  Y +  +
Sbjct: 120 LWEE--KFNSLNELVDFYRTTTI 140


>UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniota RepID=SH2D3_HUMAN
          Length = 860

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 56/303 (18%), Positives = 101/303 (33%), Gaps = 38/303 (12%)

Query: 149 EIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWK 208
            +R S  + ++   L     EP+   AT +                +        P    
Sbjct: 31  TLRRSSASISRQSHL-----EPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPSI 85

Query: 209 KERISKAFAVDIKVIKDLPWPPPVGQLD--SSPSLPDGDRDISGPASPLPEPSLEDSSAQ 266
           K+  +   A   +     P   P G  D     +  +     +GP    P      S+ +
Sbjct: 86  KKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPSAVE 145

Query: 267 FEGPEKSCLSPGREEKGRLP----PRLSAGNPKSAKPL--------------SMEPSSPL 308
            +   K  +  G  E+ R P       +AG P++                          
Sbjct: 146 VDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELE 205

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
            E    +  L +  WYHG I R  +E L++  +   +L+R+S TS  D+ L+ +     +
Sbjct: 206 EELKLSSTDLRSHAWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQAL 263

Query: 369 HMKLSRT--------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           H K+++            +Y+  Q S  F  VP +V ++   +  +       +  PV  
Sbjct: 264 HFKINKVVVKAGESYTHIQYLFEQES--FDHVPALVRYHVGSRKAVSEQSGAIIYCPVN- 320

Query: 421 RTL 423
           RT 
Sbjct: 321 RTF 323


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 63/338 (18%), Positives = 121/338 (35%), Gaps = 38/338 (11%)

Query: 92  RLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR 151
            +++  E + L + +D+ DPF+   T              PEN+ Y    + Q   AE+R
Sbjct: 26  DMQNSDEFQDLPVHDDF-DPFES-YTELPEETVDANLTAPPENEWYHGCLDRQS--AELR 81

Query: 152 GSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKER 211
            +           D P       +  +          +   +  R               
Sbjct: 82  LNAA---------DKPGSYLVRESERKPGSYVLSYLGQRGINHFRVTA------------ 120

Query: 212 ISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG-P 270
           +   F V  +  + LP         S+    +  +  + P  P+ +     ++  +   P
Sbjct: 121 VCGDFYVGGRQFQTLPELIGYYTHISNILKNERLQYPAPPPEPVDDKKKVVATLPYNKVP 180

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA----LPLENQVWYHG 326
           +   LS    E   +   L  G        S E    + +   P      P E +VW+HG
Sbjct: 181 DTDELSFSAGEVFVVHNELGGGWLWVTSQRSGESGIIVQDLVKPVEGEIDPNEGKVWFHG 240

Query: 327 AISRTDA-ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQN 385
            +S+ +A E L +      +L+RNS+ +  D+SLS +        ++ + ++ +YV+G  
Sbjct: 241 NVSKEEAAETLWKDGDIGGFLIRNSDKNPGDYSLSFRGPNTIQRFRIQK-QQRQYVMG-- 297

Query: 386 SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
              ++S+  IV HY   ++     +   L  P A +  
Sbjct: 298 GRYYNSLDAIVDHYKKEEII----DGFKLRDPTAPKKF 331


>UniRef50_B8JL24 Novel protein similar to human and mouse SH2 domain containing 4B
           (SH2D4B) n=2 Tax=Danio rerio RepID=B8JL24_DANRE
          Length = 441

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 46/237 (19%), Positives = 87/237 (36%), Gaps = 32/237 (13%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDG------- 244
           E +++  E+ D+ WE   E + +  A D ++ +   W     +  S  ++  G       
Sbjct: 188 EQEQKKSEQRDKAWE---EHLCRCKAADEEMTRKACWARDEYKRQSLRAIEKGHVAGLSG 244

Query: 245 ------DRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK 298
                  R  S    P   P   +      G +++     R  + R     +   P    
Sbjct: 245 HFQKQSQRRHSAFIEPSASPVSSNEVRPKPGLQRAEPPLYRRRQSRRHSTTTTTQPLMDS 304

Query: 299 PLSMEPSSPLGEWTDPALPLENQ---------------VWYHGAISRTDAENLLRLCKEA 343
           P  ++   P           E Q                W+HG ISR D+E LL      
Sbjct: 305 PAWLQTPRPGSRELVILWFNEEQKPKQAGYERNGKAIAPWFHGIISREDSETLLMNAAVG 364

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           S+LVR SE     ++LS +++ GF H  +  + ++   LG +    +++ +++  + 
Sbjct: 365 SFLVRVSERIWG-YTLSYRTASGFKHFLIDASGDYYSFLGVDQNRHATLADLIDFHK 420


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 31/111 (27%), Positives = 58/111 (52%), Gaps = 4/111 (3%)

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHM 370
            D  + L++  WY G ISR +  + LR   + ++LVR++ T  + D++L+L+       +
Sbjct: 54  KDSFISLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLI 113

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
           K+   ++ KY   +    F+SV E+++HY    L     +  + L YPV+ 
Sbjct: 114 KIYH-RDGKYGFSEP-LTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSR 162



 Score = 97.3 bits (240), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 29/114 (25%), Positives = 51/114 (44%), Gaps = 4/114 (3%)

Query: 310 EWTDPALPLENQV-WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
              D  LP  ++  W+   I+R  AE+LL    + ++L+R S + K  ++ S+ +     
Sbjct: 285 NEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVK 343

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAIR 421
           H  +  T    Y   +    +SS+ E+V HY    L       ++ L YPV  +
Sbjct: 344 HCVIYSTARG-YGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQ 396


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 39/182 (21%), Positives = 74/182 (40%), Gaps = 19/182 (10%)

Query: 251 PASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLS-----MEPS 305
            +   P  +   +   F+G  +  L   + +   +       N  +AK +S     + P 
Sbjct: 17  SSKNFPNGTECVARYDFKGNSEKDLPFKKGDIIEILQSTRDPNWYNAKKVSDGRTGLIPI 76

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
           + + +    AL L    W+ G I+R  AE LL   +   +LVR S     D++L + S Q
Sbjct: 77  NYVQQRR--ALHLHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQ 134

Query: 366 GFM---HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS--LLYPVAI 420
                 H ++  T +++  +      F ++ E++ HY       K A+ +   L  P+  
Sbjct: 135 NNKKVEHYRVISTSDNQVTV-DEEAFFPTLIELIKHYE------KDADGLCTMLKKPLKK 187

Query: 421 RT 422
           +T
Sbjct: 188 KT 189


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +      W+   ISR +AENLL       ++VR S+ S  DFS+S++      H K+ R 
Sbjct: 66  IDFHVPHWFDEKISRHEAENLLMSKGVGCFVVRASQNSHGDFSISVRHEDDVQHFKVMRD 125

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
            +  Y L   +  F S+ ++V +Y +  +
Sbjct: 126 SKGSYYLW--TEKFHSLNKLVDYYKTSSI 152


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score =  105 bits (261), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 11/160 (6%)

Query: 265 AQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP-LENQVW 323
             +   +    +PG     R    L +       P +++P +     +  +LP ++ Q+W
Sbjct: 220 PCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLW 279

Query: 324 ----YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
               YHG +SR  AE+LL   K+  +LVR S TS   + LS        H+ L    E K
Sbjct: 280 SEECYHGKLSRKAAESLL--VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLV-DPEGK 336

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLP-IKGAEHMSLLYPV 418
             +      F +V  ++ ++    LP I     +SL  PV
Sbjct: 337 --VRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPV 374


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  105 bits (260), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 35/147 (23%), Positives = 64/147 (43%), Gaps = 5/147 (3%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT-DPALPLENQ 321
           +   F+      LS    +K  +  R       + K +    ++    +       +E+Q
Sbjct: 73  ALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTGFVPYNYLARDSVESQ 132

Query: 322 VWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
            W+ G ++R  A + L   +    S+LVR SE+    + LS+++ +   H K+ +T +  
Sbjct: 133 PWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQTGDQF 192

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPI 406
           YV       FSS+ E++ HY S  L I
Sbjct: 193 YV--DALFKFSSIVEVIEHYQSHPLSI 217


>UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona intestinalis
           RepID=UPI00006A5E95
          Length = 572

 Score =  105 bits (260), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 28/146 (19%), Positives = 62/146 (42%), Gaps = 11/146 (7%)

Query: 286 PPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL---PLENQVWYHGAISRTDAENLLRLCKE 342
            P    GN     P S+E    L      +     + N +WYH  + R +A+ ++    +
Sbjct: 6   MPGGPTGNLVPTFPQSVETQKNLYRDVKSSNNTKEISNCLWYHFKLRREEAQAMV--VND 63

Query: 343 ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY------VLGQNSPPFSSVPEIV 396
             +L+R S +S +D+ L+L+ +   +H K+++  +                 F S+  ++
Sbjct: 64  GDFLLRQSLSSVDDYVLTLRWNATVLHFKINKFVQRHDAVNSSTFFVFERAYFDSIYSLI 123

Query: 397 HHYASRKLPIKGAEHMSLLYPVAIRT 422
            ++   ++PI       + +P+  +T
Sbjct: 124 MYHMENQIPISVLTGALIQHPITRQT 149


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score =  105 bits (260), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 7/111 (6%)

Query: 316 LPLENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           L +E   WYHG +SR  AE LL    ++ SYL+R+S T   ++SLS+K      H ++  
Sbjct: 7   LEVEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSVKHFQIG- 65

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS--LLYPVAIRTL 423
               +Y  G     F S+ E V H+A++ L I G   +   L +P +   L
Sbjct: 66  WDGKQYQFGMG--VFQSLQEFVEHFANQPL-IGGESGILTALRHPYSRNVL 113


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  104 bits (259), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 31/105 (29%), Positives = 49/105 (46%), Gaps = 7/105 (6%)

Query: 318 LENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           L  ++WYHG ISR DAE LL        S+LVR+S T+  ++ LSL       H  +SR 
Sbjct: 4   LSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISRH 63

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            +    + Q+   F S  E++ ++  +   +      +L  P   
Sbjct: 64  PDGSVAI-QDGAKFDSPIELIQYHTKKVDGLIT----TLKQPCCR 103



 Score = 75.7 bits (184), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 4/88 (4%)

Query: 318 LENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
              Q+W+HGAISR ++E  ++    ++  +LVR   T  N F+L +       H  L   
Sbjct: 158 HRKQLWFHGAISREESEQRMKAFGLRDGLFLVRE-RTEVNSFALCVAVKNDIYHYLLEMN 216

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRK 403
              +  + +N   F ++ ++V HY+   
Sbjct: 217 TLGQLSI-ENGRKFENLLQVVDHYSRTP 243


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score =  104 bits (259), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 38/126 (30%), Positives = 63/126 (50%), Gaps = 9/126 (7%)

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSK 354
             K  + +PS         A  L++  WYHG ++R  AE LL     + SYL+R+S  + 
Sbjct: 8   EGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETT 67

Query: 355 NDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE---H 411
             +SLS+++     H  +  T  + +  G N   FSS+ + V H+A++  P+ G+E    
Sbjct: 68  GLYSLSVRAKDSVKHFHVEYTG-YSFKFGFNE--FSSLKDFVKHFANQ--PLIGSETGTL 122

Query: 412 MSLLYP 417
           M L +P
Sbjct: 123 MVLKHP 128


>UniRef50_UPI000186E9A4 SH2 domain-containing protein 4A, putative n=1 Tax=Pediculus
           humanus corporis RepID=UPI000186E9A4
          Length = 472

 Score =  104 bits (259), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 44/222 (19%), Positives = 81/222 (36%), Gaps = 14/222 (6%)

Query: 206 EWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSA 265
           +W+K  + +  +     ++           D+        R+    A    +   E +  
Sbjct: 232 QWEKRVLEERASQIFNKLQRKQLQVVKEAEDAEKRQEILWREQEKKAKEAEQQIREIARR 291

Query: 266 QFEGPEK-SCLSPGREEKGRLPPRLSAGNPKSA------KPLSMEPSSPLGEWTDP---- 314
             E  ++ SC     E +     R S   P  +      KP S E  +   +  +     
Sbjct: 292 AREEHKRTSCCEIDVETETNQIKRTSTKEPVVSMSVGVIKPRSREAITEWFQTVEVERKA 351

Query: 315 --ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
                     W+HG ISR +AENLL      S+LVR SE     +++S + S    H  +
Sbjct: 352 GIDDKNHVAPWFHGLISRQEAENLLSDKPVGSFLVRVSEKISG-YAISYRDSDRCKHYLI 410

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
             +  H   LG N     ++ E++  + ++ +   G E + +
Sbjct: 411 DSSNGHYQFLGSNQMTHKTLGELITFHETQAITALGGELLRI 452


>UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1E0A
          Length = 680

 Score =  104 bits (259), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 9/112 (8%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT-- 375
           L +  WYHG + R  AE LL   +   +LVR+S ++  D+ L+       MH K+ R   
Sbjct: 16  LSSHAWYHGPLRREAAEALLE--RNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVL 73

Query: 376 ----KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                  + +       F ++P ++  Y   + PI  A    + +P+  RTL
Sbjct: 74  RPKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQASGAVISHPI-TRTL 124


>UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RR81_NEMVE
          Length = 473

 Score =  104 bits (259), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 59/301 (19%), Positives = 107/301 (35%), Gaps = 40/301 (13%)

Query: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGE 180
                 A  +   ++G    Y++    A+   + E    P   Y  P+   + G      
Sbjct: 211 KYDGGYAKLRSTSDEGVAGLYDS----ADSYRNAELPKIPGSGYAVPFARPDSGLDLN-- 264

Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
               PRES     D      YD P              D    +   +  P+    + P 
Sbjct: 265 ----PRESL----DFAAGAMYDNP-------------EDPDDGRLGFYNNPLAGASTDPR 303

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           LP     +S        P   +   +F  P +   +P       +P      NP++   L
Sbjct: 304 LPARMDSLSR---DDDIPEYHNPETRFSSPPQPTHAPKNLMDDDIPEYH---NPETQFSL 357

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
            +   +P+      +  +  + WYHG ISR +AE LL    E  +LVR S++    + LS
Sbjct: 358 PLSVHAPVASTRSSSF-MRAKDWYHGPISRGEAELLLED--EGDFLVRESKSQPGQYVLS 414

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVA 419
               +   H+ L    + +  +      F +V +++  +   ++PI  A   +++ +PV 
Sbjct: 415 GIKDKQARHLLLV-DPQGQ--VRTRDKVFENVDQLISFHLVNQVPIISAGSEVTIKHPVL 471

Query: 420 I 420
            
Sbjct: 472 R 472


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  104 bits (259), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 31/156 (19%), Positives = 58/156 (37%), Gaps = 9/156 (5%)

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
           P  +  +  +   ++G     LS  + EK ++           +     E   P   +  
Sbjct: 109 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLSTKREGFIP-SNYVA 167

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLK-----SSQG 366
               LE + W+   I+R DAE  L        ++L+R SET K  +SLS++         
Sbjct: 168 KVNTLETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDV 227

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
             H K+       Y +      F  + +++ +Y + 
Sbjct: 228 IKHYKIRSLDNGGYYIS-PRITFPCISDMIKYYQTN 262


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score =  104 bits (259), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 25/108 (23%), Positives = 49/108 (45%), Gaps = 8/108 (7%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT--- 375
            +  WYHGAI R  AENL++  ++  +L+R+S +S  ++ L+ +      H K+++    
Sbjct: 154 RSHAWYHGAIPRQVAENLVQ--RDGDFLIRDSLSSPGNYVLTCQWKNSPQHFKINKRVVA 211

Query: 376 ---KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
                 +         F S+P +V +Y   + P+       +  P+  
Sbjct: 212 MNEAYSRVQYLFEKEGFDSIPALVRYYVGNREPVSEVIGAIIFQPINR 259


>UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001927133
          Length = 521

 Score =  104 bits (258), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 42/204 (20%), Positives = 74/204 (36%), Gaps = 15/204 (7%)

Query: 219 DIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPG 278
           D  +   LP  P +    +  ++     D       + +P+          PE+  +   
Sbjct: 318 DRSMRPPLPPRPTISGPVNVSTVTRSQNDTVAIKRDVVKPTNRPP----PAPEQPDVVKN 373

Query: 279 REEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR 338
           +    R   R            S +  + L +  +P L      W+HG ISR +AE +L 
Sbjct: 374 QIRPARPKNREEVSKWWKEIEYSRQ--AGLDKEFNPLL------WFHGIISRHEAEKILE 425

Query: 339 LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHH 398
              + S+LVR SE     +++S K      H  +  +       G      +S+ E++ +
Sbjct: 426 KKDKGSFLVRVSERVWG-YTVSFKDIARCKHFLIDTSANGYQFFGTEQIVHNSLNELIDY 484

Query: 399 YASRKLPIKGAEHMSLLYPVAIRT 422
           +     PI G     L+YP    T
Sbjct: 485 HKIN--PISGLGQEILIYPCGQET 506


>UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D8F4
          Length = 792

 Score =  104 bits (258), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 26/117 (22%), Positives = 47/117 (40%), Gaps = 8/117 (6%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  A  L +  WYHG+I RT AE +L    +  +LVR+  +   +F LS K     +H
Sbjct: 61  ELSLDARDLRSHAWYHGSIPRTRAEEILES--DGDFLVRDCTSQPGNFVLSTKCKGQNLH 118

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             +++      T   +         + +V +++ +Y      I       +  P   
Sbjct: 119 FVINKVVLQPDTVYERIQFQFEDEAYDTVSDLITYYVGSGKVISSLSGARIQNPKNR 175


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  104 bits (258), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 31/105 (29%), Positives = 54/105 (51%), Gaps = 3/105 (2%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           +P+E Q WY G ISR  AE+LL   +E  +LVR+SE++  D S+S++  +   H K+   
Sbjct: 294 IPMEQQPWYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIERNKHFKVQNV 353

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
                +L   +  F  +  +++HY +  +     E + L  P+  
Sbjct: 354 DG---LLKIGNRTFVDMNALINHYTTSPIFSSPTEKLFLTGPLPK 395


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score =  104 bits (258), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 16/196 (8%)

Query: 220 IKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGR 279
            K   D        +L    S P  D+D     + L    L  S+          + P +
Sbjct: 198 FKGRTDEELNFDASELLDIISNPSDDQDWWKARNKLGTVGLVPSNYVKVVENADPVCPTK 257

Query: 280 EEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR- 338
                  P             S  PSS +G          ++ W+HG I+R D+E +L  
Sbjct: 258 FFIEDAVPPKPIEMHDEDN--SFTPSSSVG--------FYDRDWFHGRITRQDSEKILGC 307

Query: 339 LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHH 398
             +   +L+R SET   DF++S+K+ +   H K++R+ + K+ +GQ    F S+ ++V H
Sbjct: 308 PGESGLFLIRESETMPGDFAVSVKAPERVKHFKVTRS-DKKFCIGQR--KFESLDDLVDH 364

Query: 399 YASRKLPIKGAEHMSL 414
           Y     PI  ++   L
Sbjct: 365 YKRS--PIFSSDDGEL 378


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 38/172 (22%), Positives = 72/172 (41%), Gaps = 9/172 (5%)

Query: 249 SGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPL 308
           S P    P      S   ++  E + LS  + E+  +  ++     K+      E   P 
Sbjct: 210 SLPPGAAPALFEVQSLYDYDALEPTDLSLSKGERLVIVDQMEEHWWKARNNAGQEGYIP- 268

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGF 367
             +    L LE++ W+    S+  A  LL +C ++ ++LVR SE++   +SLS+      
Sbjct: 269 ANYV-RKLGLESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLSVFYQGKL 327

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
            H K+   ++  Y + +    F+S+ E++ ++        G     L  PV 
Sbjct: 328 KHYKIKHDQD-MYRVSERH-TFASISELIEYHKHNG----GGLVTRLRKPVQ 373


>UniRef50_UPI0001555700 PREDICTED: similar to hCG34612 n=1 Tax=Ornithorhynchus anatinus
           RepID=UPI0001555700
          Length = 333

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 75/316 (23%), Positives = 115/316 (36%), Gaps = 45/316 (14%)

Query: 118 GEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATA 177
           G G     G  EKV   +  + PYE Q+             +   LY           + 
Sbjct: 44  GIGVPSLEGGKEKVGSGEYEVPPYEVQRRQVTPTCPAPLKGKG--LYS-------GSGSL 94

Query: 178 EGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDS 237
           +   +   +ES      E  P     P          + +    V    P  P       
Sbjct: 95  DSTVSSPQKESPESIYLECDPHPASTP--------VPSLSRVPSVQALTPPNPQPKVSKL 146

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA 297
             +       +SGPA  +P+   E+ S   +G    CL          PP  S G P ++
Sbjct: 147 PRANTFSWAAVSGPAETVPKG--EEWSMSLQGFVPVCLPK--------PPPFSHGFPAAS 196

Query: 298 KPLSMEPS----SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS 353
           +P +  PS    SP     DP++    Q WY     R  AE++L L K+ +++VR S   
Sbjct: 197 RPAAPSPSLSRVSPWCCVQDPSI--LTQPWYADPCDRQTAESVLLLQKDGAFIVRPSSNP 254

Query: 354 KN--DFSLSLKSSQGFMHMKLSRTKEHK-YVLGQNS----PPFSSVPEIVHHYASRKLPI 406
                F+L++       ++ + R    + Y LG+        FSSV  IV HY+ + LP+
Sbjct: 255 GGSQPFTLAVLLHNRVYNVPIRRLDGGRHYALGREGKIREELFSSVAAIVKHYSRKPLPL 314

Query: 407 ----KGAEHM-SLLYP 417
                GA     LL+P
Sbjct: 315 VDRHTGARQFTCLLFP 330


>UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosiga gracilis
           RepID=B3XVX8_9EUKA
          Length = 792

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 37/199 (18%), Positives = 69/199 (34%), Gaps = 8/199 (4%)

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
           P   P+  +++S +  D    +S       +      +  F     S  S          
Sbjct: 340 PLMLPIDGVNTSETATDSKTVLSKENILDTQQHTTQDAVTFCHVASSETSTTPPPSLPTA 399

Query: 287 PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
            R+  G P   K  SM+     G+  D    +E+   Y G I R +   +L       +L
Sbjct: 400 ERMPMGQPVVNKQTSMQL--TAGDGRDGGQSVEDLECYFGPIPRNEVPMILSD--PGDFL 455

Query: 347 VRN-SETSKNDFSLSLKSSQG-FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +R  SE S   + LS+    G   H  +         +      F S+  ++ HY    L
Sbjct: 456 IRLGSENSATKYVLSVLEEGGNCRHFNIFYCPNGYVKI--EKQEFPSISHLIRHYIDNDL 513

Query: 405 PIKGAEHMSLLYPVAIRTL 423
            +     +++ + V+ + +
Sbjct: 514 SLSKNSGVTIAHGVSRKKM 532


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 10/143 (6%)

Query: 277 PGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL 336
           P R   GR   RLS+    S   +       +   TD    L+ + W+HG + R++A NL
Sbjct: 279 PPRHVSGRGGDRLSSS---SNFDMCPSTGDNISMETDIGQTLKKEFWFHGTLGRSEATNL 335

Query: 337 LRL---CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
           +          +LVR SET   +F L+        H++++   + +  +      F S+ 
Sbjct: 336 VLHDGARGHGLFLVRQSETRTGEFVLTFNFQGRAKHLRMTINDQGQCRVQHF--WFQSIY 393

Query: 394 EIVHHYASRKLPIK--GAEHMSL 414
           E++ H+  + +P++  G   ++L
Sbjct: 394 EMLEHFRQQPIPLESGGNSDVTL 416


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 33/168 (19%), Positives = 72/168 (42%), Gaps = 13/168 (7%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F+G     LS  + E  ++  +       S+   +++   P   +  P   LE + 
Sbjct: 54  ALYAFQGRNDGDLSFEKGEVLKVFDQSGDWWVASSTRTNVQGYIP-CNYVAPVNSLEVEG 112

Query: 323 WYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQ-----GFMHMKLSRT 375
           W+ G+ +R++A   L+     + ++LVR SET    ++L+++ +         + ++ +T
Sbjct: 113 WFFGSCTRSEAIMRLQADNLPKGTFLVRESETRPGTYALTVRETDHGHPPTIKNYRVDKT 172

Query: 376 KEHK-YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           K+            F++V ++V  + S+     G     LL P   +T
Sbjct: 173 KDGSELFFINPQRKFNTVIDVVKFHTSQP----GGLCSKLLKPCPKQT 216


>UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9Y7_MONBE
          Length = 947

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 6/100 (6%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE--H 378
             W+HG I+R +AE+LL       +L R SET    ++LS+++     H  +  T+E   
Sbjct: 837 HDWFHGVITRREAEDLLAPKPIGCFLTRISETRLG-YTLSVRTRHACKHFVIEETRESPS 895

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +Y+L      F ++  ++ HY          +   L  P 
Sbjct: 896 RYMLQGRDVYFDTLERLIEHYRGHP---ANDQGDHLTVPC 932


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 11/160 (6%)

Query: 265 AQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP-LENQVW 323
             +   +    +PG     R    L +       P +++P +     +  +LP ++ Q+W
Sbjct: 463 PCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLW 522

Query: 324 ----YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
               YHG +SR  AE+LL   K+  +LVR S TS   + LS        H+ L    E K
Sbjct: 523 SEECYHGKLSRKAAESLL--VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLV-DPEGK 579

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLP-IKGAEHMSLLYPV 418
             +      F +V  ++ ++    LP I     +SL  PV
Sbjct: 580 --VRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPV 617


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 36/188 (19%), Positives = 67/188 (35%), Gaps = 4/188 (2%)

Query: 213 SKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK 272
           S      I   +     P      +   +P   +       P P         Q   P  
Sbjct: 270 SAQLQNHILTSQQQQQQPASAGQGAGVVIPPQQQQQPPQVPPAPHGMSNSMHGQIGLPPP 329

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
                G  +   +    + G P S+  LS   ++      +    L    W+HG I R +
Sbjct: 330 PSAIGGAFDSNGVSWVGAGGVPTSS--LSPTAAAAAQRRAEVNAKLNAMPWFHGRIKREE 387

Query: 333 AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSV 392
           AENLL+  ++  +LVR S     D++L +  ++   H ++   +    +   +   F ++
Sbjct: 388 AENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKYAENK--LTIDDDEYFDNL 445

Query: 393 PEIVHHYA 400
            ++V HY 
Sbjct: 446 GQLVEHYT 453


>UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2C7_MONBE
          Length = 592

 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 54/309 (17%), Positives = 111/309 (35%), Gaps = 24/309 (7%)

Query: 133 ENDGYMEPYEAQKMMAE---IRGSKETATQPLPLYDTPYEPEEDG-----ATAEGEGAPW 184
            +  Y E YE +    E    +  ++     L   D P            ++++ E    
Sbjct: 223 PDADYEERYEPEFDEDEQDAAQSDQDADDVALEELDGPSNTSIQDKAAPESSSDSELVVV 282

Query: 185 PRESRLPEDDERPPE---------EYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQL 235
                   +DE             E D   E ++  I         ++        +G  
Sbjct: 283 DSNDAQASEDEADATNDLGESDDWEADLQAELQELEIEGLQVTRPSLLMLHLSCTLIGLS 342

Query: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
               +       +S        PS+       +  +K  +            +L+     
Sbjct: 343 SGVQTPLKLSLPMSALTFSYIFPSISIQPRVIQTKDKR-MERQGHRVVFSLTKLTLRALV 401

Query: 296 SAKPLSMEPSS----PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNS 350
           +A P S   +S       +  D      ++ +YHG ISR +A   L+    + ++L+R S
Sbjct: 402 AALPSSFLFTSLTLKMSRKLVDVDESGVDRSYYHGTISREEAVRRLQEVNTDGAFLLRLS 461

Query: 351 ETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP-IKGA 409
            T K+ +++SL+S+    H++++ T    Y LG++   F S+ +++     + L   KG 
Sbjct: 462 ATQKDAYTISLQSNGEIKHIRVTNTSNGGYALGKSKEEFESIWDLIEAQLDKSLKSTKGD 521

Query: 410 EHMSLLYPV 418
           + + L++P+
Sbjct: 522 QAVQLVHPL 530


>UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=1 Tax=Schistosoma
           mansoni RepID=C4QLR4_SCHMA
          Length = 409

 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 42/215 (19%), Positives = 78/215 (36%), Gaps = 11/215 (5%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
            + + A + +  +  +     PV   +    L +     +   S         +      
Sbjct: 202 SKENTALSQNTSMPNNNVTHQPVAFDNFMGHLGNEISSDNQTDSAEYNKPSCGTKKSSAQ 261

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
             ++ L+    ++        AG  KS   +      P  E  +P      + WY G +S
Sbjct: 262 SNQNELTQELSQQPSRKINKVAG-VKSISNIKAPVGLPNFEHLEPV----GEPWYVGKMS 316

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R+ AENLLR   +  +LVR S      F LS      + H+ L+     K  +      F
Sbjct: 317 RSQAENLLRY--DGDFLVRASIQQPGQFVLSGLQDGKYRHLLLA-DPNGK--VRTKERVF 371

Query: 390 SSVPEIVHHYASRKLPIKG-AEHMSLLYPVAIRTL 423
            S+  ++ ++     PI+     + L++PV+  T 
Sbjct: 372 DSIQHLIDYHVQNGAPIRSLDSEIRLIFPVSTHTF 406


>UniRef50_B2MW85 Phosphatidylinositol 3-kinase 60 n=1 Tax=Bombyx mori
           RepID=B2MW85_BOMMO
          Length = 577

 Score =  103 bits (256), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 38/158 (24%), Positives = 68/158 (43%), Gaps = 15/158 (9%)

Query: 276 SPGREEKGRLPPRLSAGNPKSAKPLSME----PSSPLGE--------WTDPALPLENQVW 323
              R   GR   ++    P+      ++    PSSP  E           P   LE   W
Sbjct: 140 HIARRTDGRWGQKVLEWRPRLEDVAKLDNYTAPSSPDDEIMVEIGVPQQSPEHSLEAAEW 199

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           Y G I+R +A   LR  ++ ++LVRN+    + ++L+++       +K+    E +Y   
Sbjct: 200 YWGDITRDEANEKLRDTRDGTFLVRNASNKDSGYTLTVRKGGANKLIKIYHH-EGRYGF- 257

Query: 384 QNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
           +    F SV ++V +Y+   L    +   + LLYP++ 
Sbjct: 258 REPFEFKSVVDLVCYYSEYSLATCNSSLDIKLLYPLSR 295



 Score = 80.7 bits (197), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 4/95 (4%)

Query: 327 AISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS 386
             +R  AE LL    + ++L+R + T     +LS+  +    H  +++T+   Y   +  
Sbjct: 477 NCTRETAEKLLAGKPQGTFLIRPNST--GQLALSIVCNNMVYHCIINKTECG-YGFAEPY 533

Query: 387 PPFSSVPEIVHHYASRKLPIKGAEHMS-LLYPVAI 420
             + ++ E+V HYA   L     +  + L YPV +
Sbjct: 534 NIYETLNELVLHYAGNSLEEHNDQLRTELKYPVNM 568


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 54/279 (19%), Positives = 91/279 (32%), Gaps = 9/279 (3%)

Query: 144 QKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQ 203
           Q +       +   +        P +    G   +    P P      +   +  + Y Q
Sbjct: 323 QSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKE-QTYYQ 381

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
                           ++      +  P G+L  +P+        +    P   P+   S
Sbjct: 382 GRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSS 441

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
           +     P K        E       L     K+A    + P SP          L+ + W
Sbjct: 442 AES--SPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETW 499

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           Y G +SR +AE LL   K+  +LVR S T+   F L+   +    H+ L    E    + 
Sbjct: 500 YQGEMSRKEAEGLLE--KDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLV-DPEG--TIR 554

Query: 384 QNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVAIR 421
                F S+  +++H+    LPI  A   + L  PV  +
Sbjct: 555 TKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593


>UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Euteleostomi
           RepID=A2AK86_MOUSE
          Length = 236

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           +  L +  WYHG I R  +E L++  +   +L+R+S TS  D+ L+ +     +H K+++
Sbjct: 54  STDLRSHAWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWHNQALHFKINK 111

Query: 375 T--------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                       +Y+  Q S  F  VP +V ++   +  +       +  PV  RT 
Sbjct: 112 VVVKAGESYTHIRYLFEQES--FDHVPALVRYHVGSRKAVSEQSGAIIYCPVN-RTF 165


>UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containing 4B n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A0859
          Length = 488

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 57/292 (19%), Positives = 105/292 (35%), Gaps = 42/292 (14%)

Query: 138 MEPYEAQKMMAEIRGSK-ETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPE--DD 194
           ME  +A K++ E    + +   +   LY T  + +    T+E E   W  + R  +  D+
Sbjct: 220 MEDRKAAKVLEERIREEFKEEQRAKELYWTLKQAQLQSGTSEHEEREWEEQLRRSKAADE 279

Query: 195 ERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASP 254
           ER         E+++  +       +  +  +           +            P   
Sbjct: 280 ERSRGAQRARDEYRRHSLRAIQKGTVAGLSSMFQELGQSHEQEARLYHHLPGPGPPPPLA 339

Query: 255 LPEPSLEDSSAQFEGPEKSCLSPGREEKGR-----LPPRLSAGNPKSAKPLSMEPSSPLG 309
           +P  +           E+      RE   R       PR  AG  ++ K ++        
Sbjct: 340 IPVRTW----------ERPLRPVSREVIVRWFKEEQLPRR-AGFERNTKSIAP------- 381

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
                        W+HG ISR DAE+LL    E ++LVR SE     ++LS +  +GF H
Sbjct: 382 -------------WFHGIISREDAEDLLENMTEGAFLVRVSEKIWG-YTLSYRLQKGFKH 427

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
             +  + +    LG +    +++ +++  +    + + G E   L  P   R
Sbjct: 428 FLVDASGDFYSFLGVDPNRHATLTDLIDFHKEEIITVSGGE--LLQEPCGQR 477


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 26/112 (23%), Positives = 55/112 (49%), Gaps = 4/112 (3%)

Query: 290 SAGNPKSAKPLSMEPSS--PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
           S+G+  +    S+ P++  P    +   + L    W+HG+I+R +AE+LL+  ++  +LV
Sbjct: 444 SSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLV 503

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           R S     D++L +       H ++   +    +   +   F ++ ++V HY
Sbjct: 504 RESTNFPGDYTLCVCFQSKVEHYRVKYLENK--LTIDDEEYFENLGQLVAHY 553


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 38/171 (22%), Positives = 70/171 (40%), Gaps = 10/171 (5%)

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLS---MEPSSPLGEWTDP 314
            S+  +   F+  +   LS    +  R+  R            S   ++     G +  P
Sbjct: 1   GSIYRALWAFQSQQGEHLSFREGDLFRVLSRRDDWWSVRRIDASGRVLDSGLVPGNYLAP 60

Query: 315 ALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           A   + Q W+ G ++R  A++ L      E ++L+R SE     + LS++S     H K+
Sbjct: 61  AESGQTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKV 120

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            +T ++++ + +    FSS+ E+V +Y    L         L  P    TL
Sbjct: 121 LQTDQNRFYV-EPGRRFSSLAELVDYYQKTSL----NNAGPLGNPCKRNTL 166



 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 7/102 (6%)

Query: 322 VWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
            WY+G I+R  AE LL     K+ S+LVR SE+  +++++S +S     H ++ R+    
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGA 308

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           Y +      F+++ E++ +Y      +     + L  P A +
Sbjct: 309 YFVSDR-ISFATLGELISYYQRNNRSL----GVLLEEPCAQQ 345



 Score = 88.1 bits (216), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 46/259 (17%), Positives = 75/259 (28%), Gaps = 16/259 (6%)

Query: 166 TPYEPE-EDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIK 224
            PYE   + GA      +      R  +     P     P       +S +   +     
Sbjct: 568 MPYEGRNQPGAGWNSRRSRSLPVCRKEQQGGSGPAGVRVP-----AAVSHSLPPEHLPHD 622

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
           D        Q    P           P            +    G      +  +     
Sbjct: 623 DGLLGGRALQEALLPRPAQPAGRHLRPHLLQDHRVPAGGAPVLPGGGPVSGAEPQGRLVV 682

Query: 285 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
                        +P S E   P G   D A+   +     G       EN      E +
Sbjct: 683 GAEDRRQRPRPGQRPGSGELPGPGGVRPDAAMVFRDAEPPSGPEPPVAPEN-----SEGA 737

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +L+R SE     + LS++S     H K+ +T ++++ + +    FSS+ E+V +Y    L
Sbjct: 738 FLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYV-EPGRRFSSLAELVDYYQKTSL 796

Query: 405 PIKGAEHMSLLYPVAIRTL 423
                    L  P    TL
Sbjct: 797 ----NNAGPLGNPCKRNTL 811


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 30/106 (28%), Positives = 57/106 (53%), Gaps = 10/106 (9%)

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSL-KSSQGFM---HMK 371
           L L N+ W+HG I R +AENLL+  +  ++L+R SET K  ++L++ +   G     H +
Sbjct: 61  LDLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKGSYTLTMIQIKDGTKQISHFR 120

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           ++   + KY +  ++  F  + +++ HY      +      +L+YP
Sbjct: 121 INY-DDGKYFI-TSARRFLGLHQLIQHYMQNSDGLA----CNLVYP 160


>UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q8AVM4_XENLA
          Length = 676

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 26/110 (23%), Positives = 52/110 (47%), Gaps = 12/110 (10%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT--- 375
            +  WYHG I R  +E+L++  +   +L+R+S TS  D+ L+ +     +H K+++    
Sbjct: 35  RSHAWYHGRIPREVSESLVQ--RNGDFLIRDSLTSLGDYVLTCRWKNESLHFKINKVMVK 92

Query: 376 -----KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
                   +Y+  Q S  F ++P +V +Y   + P+       +  P+  
Sbjct: 93  TSDSYTRIQYLFEQES--FDNIPALVRYYVGSRRPVSEQSSAMIYCPINR 140


>UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P596_BRUMA
          Length = 119

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 32/114 (28%), Positives = 54/114 (47%), Gaps = 5/114 (4%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
                AL L+ Q WYHG + R  AE++LR   E  +LVR S  + N+F LS  ++    H
Sbjct: 4   CNLPAALGLDRQPWYHGEMERATAESMLRN--EGDFLVRISPNTANNFVLSGIANSVARH 61

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAIRT 422
             L    + K  + +    F ++ E++ ++    +PI      + L+ P+   T
Sbjct: 62  FLLLDENDQK--VRKQQQVFETIVELIEYHRGENVPIISEGSELHLIRPIVRFT 113


>UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZG2_MONBE
          Length = 1021

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 37/141 (26%), Positives = 59/141 (41%), Gaps = 7/141 (4%)

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPL-GEWTDPALPLEN-----QVW 323
            E         +  R PP + AG  KS + L  + S     E  +P    ++       W
Sbjct: 768 AEDMRRHASGIQPRRPPPSVPAGPRKSEQELKRDASIAWWKEKEEPRGAGKDSYGGFMPW 827

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           +HG ISR +AE LLR      +LVR SE     ++LS + S    H  + +  + +Y L 
Sbjct: 828 FHGLISRREAEELLRPRYIGCFLVRVSENRFG-YTLSYRVSDRCRHYMVEQNTQGQYALV 886

Query: 384 QNSPPFSSVPEIVHHYASRKL 404
             S    S+ E++  +    +
Sbjct: 887 GVSKIADSLNELIEWFQRNPI 907


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 42/86 (48%), Gaps = 1/86 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           EN  W+HG ISR  AE +LR    +  ++VR S +S+ DF LS+      +H ++ R  +
Sbjct: 5   ENLCWFHGKISRERAEEILRQEGGDGVFMVRESASSEGDFVLSVLFQDEMVHYQIRRHGD 64

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRK 403
             +    +  P   +  ++ HY    
Sbjct: 65  DAFFSIDDHTPIHGLESLIEHYRESP 90



 Score = 61.5 bits (147), Expect = 6e-08,   Method: Composition-based stats.
 Identities = 28/120 (23%), Positives = 44/120 (36%), Gaps = 34/120 (28%)

Query: 313 DPALPLENQ-VWYHGAISRTDAENLLR------------------------------LCK 341
           +PA PL N+  WYHG + R  A ++L+                              L  
Sbjct: 273 EPAQPLTNKSQWYHGTLDRQIAVDILKEHAGKLMPGACSPSKEDKENDSTRSNDNETLDT 332

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
              YLVR S     D  L+L       H  + R +   Y+   + P  +S+  ++ HY+ 
Sbjct: 333 SGVYLVRYSPKQGVD-VLTLLFDNEARHFIIQRKQN--YLYIDDGPYMASLEHLIEHYSR 389


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 4/102 (3%)

Query: 320 NQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            + W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    + 
Sbjct: 324 RRKWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDF 383

Query: 379 KYVLGQNSPPFSSVPEIVHHYASR-KLPIKGAEHMSLLYPVA 419
             + G     F+++PE+V +Y    +L  K  + + L  P+ 
Sbjct: 384 FDLYG--GEKFATLPELVQYYMENGELKEKNGQAIELKQPLI 423


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 37/166 (22%), Positives = 69/166 (41%), Gaps = 9/166 (5%)

Query: 244 GDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSME 303
           G   +S P+SPLP+ +L  +   +       L   + +K ++  +  +     A+ L+  
Sbjct: 39  GFSQLSPPSSPLPD-NLVVAIYSYNPKHDGDLGFEKGDKLKIINKDDS-EWYLAESLTTG 96

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSL 361
               +         +E + W+   ISR +A   L        S+LVR SET+   +SLS+
Sbjct: 97  QRGYIPYNFIAMSTMETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSM 156

Query: 362 KS----SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
           +       G  H ++       + +      F+S+ E+V HY+   
Sbjct: 157 RDFDNNGDGVKHYRIRNMDNGGFYITT-KISFNSLKELVQHYSRDS 201


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 45/236 (19%), Positives = 88/236 (37%), Gaps = 16/236 (6%)

Query: 200 EYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPS 259
           EYD  +E +  R S+   +    I+       + +             +        E  
Sbjct: 489 EYDCLYE-EYTRTSQELQMKRTAIEAFNETIKIFEEQCETQERYSRESLERFQREGNEKE 547

Query: 260 LEDSSAQFEGPE-KSCLSPGREEKGRLPPRLSAGN-PKSAKPLSMEPSSPLGEWTDPALP 317
           ++   +  E  + +       + K     R  A    K  +   +     +    D +  
Sbjct: 548 IQKIQSNSERLKSRVKEIHDSKRKLEQDLRQQAWLIQKGTRQKKINEWLGIKNEADDSYS 607

Query: 318 LEN---------QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
           LE            WY G I R+ AE +LR   + ++L+R S+T K  ++ S+       
Sbjct: 608 LEEDESSPHHDESTWYVGDIKRSQAEEMLRGTCDGTFLIRESQTQKGSYACSVVVDGDTK 667

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH--MSLLYPVAIRT 422
           H  + +T    Y   +    +SS+ ++V HY +  L ++  +H  ++L +PV  R+
Sbjct: 668 HCVVYKTVTG-YGFAEPYNLYSSLKDLVLHYKNVSL-VQHNDHLNVTLAHPVLARS 721



 Score = 98.1 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 38/160 (23%), Positives = 70/160 (43%), Gaps = 8/160 (5%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
            +   EG  ++ +     E+           P       + PS+     TD +  L +  
Sbjct: 306 WTPLDEGFAETVVEKLLTERTTEQDVTPPVLPAKPAKSKVAPSAM----TDTSSLLNDAE 361

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           WY G ISR +    LR   + ++LVR++ +  + +++L+L+       +K+   +E +Y 
Sbjct: 362 WYWGEISREEVNEKLRDTPDGTFLVRDASSKLEGEYTLTLRKGGNNKLIKIYH-REGRYG 420

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
             +    F SV E+++HY    L    A+    LLYPV+ 
Sbjct: 421 FSEP-LTFLSVVELINHYRHESLAQYNAKLDTKLLYPVSK 459


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 36/176 (20%), Positives = 65/176 (36%), Gaps = 5/176 (2%)

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
           PP    + +  + P      S    P  +                 LS    +K  +   
Sbjct: 210 PPAFTAIPTGNAPPLSLPPRSPAPPPAQKMLEVRVMYSHNATTPGDLSITEGDKLWVID- 268

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLV 347
            S  N   A+            +   A  +E++ W+HG ISR +A  LL + K E  +LV
Sbjct: 269 QSEPNWWKARDSQGRVGYIPSNYVRQA-GIESEAWFHGRISRAEAAALLHVAKQEGCFLV 327

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
           R SE+   ++SLS+       H  + +  E  Y+   +   F  + +++ ++    
Sbjct: 328 RESESKVGEYSLSVSHGDSLRHYHIKKEGEEFYI--NDRHRFPDICKLIEYHKLNS 381


>UniRef50_UPI0001758844 PREDICTED: similar to vav1 n=1 Tax=Tribolium castaneum
           RepID=UPI0001758844
          Length = 784

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 43/156 (27%), Positives = 71/156 (45%), Gaps = 25/156 (16%)

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAI 328
           G  K C++           R  + N  S   L M  +            L +++W+ G +
Sbjct: 573 GVHKHCIAHS--------GRCGSHNHHSTSDLVMNGADA---------CLRDKLWFVGEM 615

Query: 329 SRTDAENLLRLCKEASYLVRNSETS--KNDFSLSLKSSQGFMHMKLSRTK--EHKYVLGQ 384
            R+ A+N L   +  ++LVR    S  K+ ++LSLK++    HMK+  T   E KY L  
Sbjct: 616 DRSRAQNELERRENGTFLVRIRPQSEDKDKYALSLKTNDTVKHMKICSTGEHEGKYYLSL 675

Query: 385 NSPPFSSVPEIVHHYASRKLP---IKGAEHMSLLYP 417
            S  FS++ E+V +Y +  L     +  E+  LL+P
Sbjct: 676 -SKFFSNIEELVLNYQTNSLKENFERLEENTKLLWP 710


>UniRef50_UPI000069EA62 SH2 domain-containing protein 4A (Protein SH(2)A). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI000069EA62
          Length = 278

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 3/98 (3%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           + W+HG ISR ++E LL      S+L+R SE  +  + LS  S +G  H  +  +     
Sbjct: 170 EPWFHGIISRQESEQLLGSHGHGSFLLRVSEKIQG-YVLSYCSEEGCAHFLIDASATSYS 228

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            LG +    +++ ++V ++ +  +P  G E   L +P 
Sbjct: 229 FLGVDQLQHTTLADLVEYHKTEPIPSLGRE--LLRFPC 264


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 24/78 (30%), Positives = 43/78 (55%), Gaps = 2/78 (2%)

Query: 327 AISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS 386
            ++R  AE LL+   + ++L+R SE +  D+SLS+K   G  H K+ R    KY L    
Sbjct: 27  KVTRDGAEELLKNDGDGAFLIRESEGTPGDYSLSVKFVDGVQHFKVLRDGAGKYFLWV-- 84

Query: 387 PPFSSVPEIVHHYASRKL 404
             F+S+ ++V ++ +  +
Sbjct: 85  VKFNSLNQLVEYHRTSSV 102


>UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine phosphatase, non-receptor
           type 11 n=1 Tax=Hydra magnipapillata RepID=UPI00019269FE
          Length = 544

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 28/124 (22%), Positives = 58/124 (46%), Gaps = 2/124 (1%)

Query: 298 KPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKND 356
              S+E + PL + ++    L  + W+ G I R +AE +L +  +  SYLVR S T   +
Sbjct: 99  NNKSVELTEPLIDDSENDPGLSQEKWFFGEIGRGEAELILKQRGEHGSYLVRESRTQPGN 158

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH-MSLL 415
           F LS++     +   L  +     +       F ++  +++++ +  L  K ++  + L+
Sbjct: 159 FVLSVRHHNSVIEFLLIYSDGAFDIANTKRLKFPTMTHLINYFITNPLIHKDSDQAIHLI 218

Query: 416 YPVA 419
            P+ 
Sbjct: 219 EPLC 222



 Score = 86.5 bits (212), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 23/108 (21%), Positives = 50/108 (46%), Gaps = 5/108 (4%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           A  L +   +   ++  +AE+LL+      SYL R S +S   ++LS++  +   + K++
Sbjct: 5   AFSLRSSWGFFANLTVAEAESLLKEKGNHGSYLCRRSTSSPGSYTLSVRRQKEVWNFKIT 64

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI--KGAEHMSLLYPVA 419
              E   +   +   F+SVP+++ +Y         +  + + L  P+ 
Sbjct: 65  NDGESFGLYENDG--FASVPDLIEYYQHNPSKFLDQNNKSVELTEPLI 110


>UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T185_NEMVE
          Length = 983

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 38/203 (18%), Positives = 78/203 (38%), Gaps = 7/203 (3%)

Query: 209 KERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFE 268
           K    +      K    +    P   +  +   P+  R +S P     +  +  +   F 
Sbjct: 543 KCPECRGNRRPNKSFTGVSPFMPRSPISLASISPERQRKVSAPPRMGTDAQVVVAIQNFH 602

Query: 269 G---PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW-Y 324
           G     +S L+    ++G      + G       ++   ++  G   +  L +      +
Sbjct: 603 GIAPSGRSSLNMVIGDEGLSIRTGTTGYF-PRSHVTSTENADAGNKQNQGLSIRTGTTGF 661

Query: 325 HGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQ 384
            G + RT+AE       + ++LVR S     +++LS++      H+K+   ++  + L Q
Sbjct: 662 AGKMDRTEAEQETMGRSDGTFLVRESANRAGEYALSVRFRNATKHIKIPY-EDGTFCLTQ 720

Query: 385 NSPPFSSVPEIVHHYASRKLPIK 407
            S  F S+PE+V +Y    L + 
Sbjct: 721 -SKVFDSIPELVAYYRENTLGVS 742


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 32/102 (31%), Positives = 58/102 (56%), Gaps = 6/102 (5%)

Query: 318 LENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           L ++ WY+G+I+R   +NLL +   +  +L+R+SET+  D+S+SLK+     H ++   +
Sbjct: 307 LVDKPWYYGSITRYMCDNLLNQRGHDGDFLIRDSETNVGDYSVSLKAPGRNKHFRV-HVE 365

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
              Y +GQ    F ++ ++V HY  ++ PI   +    LY V
Sbjct: 366 GALYCIGQR--KFHTLDQLVDHY--QRAPIYTNKQGEKLYLV 403


>UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S6Q5_TETNG
          Length = 803

 Score =  101 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 26/110 (23%), Positives = 48/110 (43%), Gaps = 8/110 (7%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR-- 374
            L +  WYHGAI R  AENL++  ++  +L+R+S +S   + L+ +      H K+++  
Sbjct: 30  ELRSHAWYHGAIPRQVAENLVQ--RDGDFLIRDSLSSPGSYVLTSQWRNTAQHFKINKKV 87

Query: 375 ----TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
                   +         F SVP ++  Y   + P+       +  P+  
Sbjct: 88  VALNEAYTRVEFRLEREGFDSVPALIRFYVGNRKPVSQVVGAIIFQPINR 137


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score =  101 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 44/187 (23%), Positives = 73/187 (39%), Gaps = 8/187 (4%)

Query: 237 SSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKS 296
              + P   R ++ P  P P  S E SS        +       E      +  + +   
Sbjct: 316 GQEATPASVRPMASP-QPTPVMSHELSSGGGGALAIAAAIGVSREHTPTNQKRPSVDAFD 374

Query: 297 AKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
            +P +    +P    T     L+++ W+HG ++R +AE LL    +  +LVR S T+K  
Sbjct: 375 MRPFA-NTLNPPATPTSATNALQSKPWFHGHVTRKEAEQLLS--HDGDFLVRESTTTKGQ 431

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL- 415
           F LS      + H+ L        V+      F SV  ++  +    LPI  +  + LL 
Sbjct: 432 FVLSGVQDGQYKHLLLVDPNG---VVRTKDRQFDSVSHLISFHRDNTLPIVSSGSVLLLR 488

Query: 416 YPVAIRT 422
            PV  + 
Sbjct: 489 QPVTRQI 495


>UniRef50_A8P112 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P112_BRUMA
          Length = 931

 Score =  101 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 28/84 (33%), Positives = 48/84 (57%), Gaps = 2/84 (2%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           Q WY G + R D+E LLR   + ++LVR S +++  + +S+  +    H K+ ++ E +Y
Sbjct: 772 QQWYRGPMKRWDSEELLRGTPDGTFLVRFS-SAQQKYVISISFNGDVKHTKVEQSPEGRY 830

Query: 381 VLGQNSPPFSSVPEIVHHYASRKL 404
            L   S  FSSV E++++Y    L
Sbjct: 831 YL-DESTMFSSVVELINYYRENNL 853


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  101 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 33/153 (21%), Positives = 61/153 (39%), Gaps = 5/153 (3%)

Query: 253 SPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT 312
           SPL  P +  SS +F  P  S  S     +    PR +  +P+S    S       G  +
Sbjct: 593 SPLISPRVTTSSPRFNFPPSSGGSNSPHSQLSSSPRHNNPSPRSHHNTSPGACRRGGINS 652

Query: 313 DPALPLENQVWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
              +    Q W+H  ++R +   L   +   +  +L+R S+     F LS   +Q   H 
Sbjct: 653 GIHM---TQPWFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSFSHNQKVKHY 709

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
           +++  ++  Y +      F+ + ++V  Y    
Sbjct: 710 QINMVEDGVYTIDDGGTRFTDLIQLVEFYQLNS 742


>UniRef50_UPI0000E48AB6 PREDICTED: similar to B-cell linker n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E48AB6
          Length = 591

 Score =  101 bits (250), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 49/190 (25%), Positives = 80/190 (42%), Gaps = 19/190 (10%)

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA 297
               P           PLP+ +   S  Q   P +S +    E       RL+   P   
Sbjct: 402 QRKEPWKSESWKSEMPPLPQGTRRPSQPQLPMPNQSSVHQINE-------RLAPSQPAKP 454

Query: 298 KPL-SMEPSSPLGEWTDPALP-----LENQVWYHGAISRTDAENLLRLC-KEASYLVRNS 350
            P  S  P SP      PA P     LE   WY+G I R ++E  L  C K+ +++VRNS
Sbjct: 455 APSGSRAPPSPSRVHVPPAQPQQVNELEGHPWYNGGIGRQESEKYLHQCRKDGAFIVRNS 514

Query: 351 ETSK--NDFSLSLKSSQGFMHMKLSRTKEHKYVLG---QNSPPFSSVPEIVHHYASRKLP 405
                 N +SL+L  +    ++++ + K+ +Y LG    N   F +  +++ H+ +  L 
Sbjct: 515 TRGDPANPYSLALWFNGRVRNLQIRKRKDQRYALGSRKDNELAFDTPVQLIEHHMTNSLI 574

Query: 406 IKGAEHMSLL 415
           +   E  ++L
Sbjct: 575 LAQDEGKTIL 584


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score =  101 bits (250), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 31/129 (24%), Positives = 60/129 (46%), Gaps = 3/129 (2%)

Query: 293 NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
            P      +M P +P          L    WY G ISR +A+++L    + S+LVR++ +
Sbjct: 2   QPSPLHYSTMRPQAPGSLVDPNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS 61

Query: 353 SKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-H 411
            K +++L+L        +K+    + KY   + +  F+SV E++++Y    L +      
Sbjct: 62  MKGEYTLTLMKDGCEKLIKICHM-DRKYGFIE-TDLFNSVVEMINYYKENSLSMYNKTLD 119

Query: 412 MSLLYPVAI 420
           ++L  P+  
Sbjct: 120 ITLSNPIVR 128



 Score = 67.6 bits (163), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 18/91 (19%), Positives = 37/91 (40%), Gaps = 4/91 (4%)

Query: 329 SRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP 388
            R +AE +L+     ++L+R        ++LS+       H  +  T    +        
Sbjct: 343 KRRNAEEMLKGAPSGTFLIR--ARDAGHYALSIACKNIVQHCLIYETSTG-FGFAAPYNI 399

Query: 389 FSSVPEIVHHYASRKLPIKGAEH-MSLLYPV 418
           ++++  +V HYA+  L         +L +PV
Sbjct: 400 YATLKSLVEHYANNSLEEHNDTLTTTLRWPV 430


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score =  101 bits (250), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 32/102 (31%), Positives = 58/102 (56%), Gaps = 6/102 (5%)

Query: 318 LENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           L  + WY+GAI+R+  + +L     +  +L+R+SET+  D+S+SLK+     H ++   +
Sbjct: 443 LAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLKAPGRNKHFRV-HVE 501

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           ++ Y +GQ    F S+ ++V HY  ++ PI   +    LY V
Sbjct: 502 QNMYCIGQR--KFHSLDQLVDHY--QRAPIYTNKQGEKLYLV 539


>UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7P6T2_IXOSC
          Length = 702

 Score =   99 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 47/114 (41%), Gaps = 9/114 (7%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           +  + +  WYHG I R  AE L+    +  +LVR+  +   D+ L+       +H  +++
Sbjct: 20  SRDMRSHAWYHGTIPRQRAEELM--TADGGFLVRDCVSRPGDYVLTCCWKGAPLHFVINK 77

Query: 375 ------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP-VAIR 421
                 T   +         F +VP++V  Y   K PI  A    +  P V  R
Sbjct: 78  VVLQPYTVYERIQYQFEDDCFDTVPDLVTFYVGNKRPISAASGAVVSRPYVVTR 131


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score =   99 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 83/408 (20%), Positives = 139/408 (34%), Gaps = 59/408 (14%)

Query: 22  RQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSN 81
           +QGS G      P G   +A P  +  +  P NS  A     SS+P+    GP+     +
Sbjct: 164 QQGSGGSSPVGPPPGY--TANPPPYFDSNHPSNSSQA-----SSNPR----GPQGATPGH 212

Query: 82  WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
              T RL  I         P       +   +   T   +       ++   N+   +P 
Sbjct: 213 QPMTGRLIDID------SEPPIYGATASPSRNNGPTALDNPLQRSCKQRPTHNNNIKKP- 265

Query: 142 EAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEY 201
                      S++   +   LYD P  P ++   A+ +    P E    ++    P+  
Sbjct: 266 -----------SRKAKRRTPSLYDNP--PTKEDVEAKVKQLT-PAERNQYQNIIANPD-- 309

Query: 202 DQPWEWKKERISKAFAVDI----KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
                WKK   S    + +    K  K +       Q     ++     D          
Sbjct: 310 -----WKKLVDSGYDNLRMLNVWKQSKSVMLHKGGDQEGEYANVACFHDDHDDDDDDDEH 364

Query: 258 PSLEDSSAQFEGPEK--SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
            +  D   + E         +P   ++   P     G      P  M P         P 
Sbjct: 365 GNRNDGEEEEEEEVDDAQPFNPEAAKQPSNPSAGGGGGASGLHPHDMAP---------PT 415

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
            PL N+ W+HG +SR + E LL    +  +LVR S T+K+ + LS   +    H+ L   
Sbjct: 416 NPLYNEEWFHGPMSRKEGEPLLSN--DGDFLVRESTTAKDQYVLSGMQNGTPKHLLLV-D 472

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            + K  +      F SV  +++++ + +LPI  A     L    +R  
Sbjct: 473 PQGK--VRTKDKEFDSVSHLINYHRNNRLPIISAGSAVHLKTPVVRKF 518


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score =   99 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 26/86 (30%), Positives = 44/86 (51%), Gaps = 1/86 (1%)

Query: 319 ENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           E   W+HG +SR DAE L++ L  E  +LVR S  S  DF L+L  +   +H ++ R  E
Sbjct: 5   ECISWFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGE 64

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRK 403
             +    N   F  +  +++++   +
Sbjct: 65  DAFFSIDNEHIFHGLETLINYHQENE 90



 Score = 88.1 bits (216), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 4/96 (4%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQ 365
           L ++  P   L    WYHG + R +A  LL+    KE SYLVR S  +   + L++  + 
Sbjct: 269 LRKYKAPKPVLSKYNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVND 328

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
              H ++    E+ Y    + P   S+  ++ +Y+ 
Sbjct: 329 RSFHFQIK--NENGYYFIDDGPLLESLEHVIDYYSR 362


>UniRef50_UPI00017930CA PREDICTED: similar to SH2 domain containing 4A n=1
           Tax=Acyrthosiphon pisum RepID=UPI00017930CA
          Length = 410

 Score =   99 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 62/366 (16%), Positives = 123/366 (33%), Gaps = 25/366 (6%)

Query: 77  KKKSNWRSTTRLRIIRLRDRLEPRPLA-ILEDYADPFD--VQETGEGSAGASGAPEKVPE 133
           ++ S W     ++   L+ +   + +  +L+   +P+   + E  +         E+  E
Sbjct: 37  RRWSVWDHNEGIKPAYLKRQKNNKKVQWMLDTNGNPWTWIMGEHKDDKTIEQIIEEEARE 96

Query: 134 NDGYMEPYEAQKMMAEIRGS-KETATQPLPLYDTPYEPEEDGATAE---GEGAPWPRESR 189
                  +E +++  ++                 P E +   AT E          R +R
Sbjct: 97  AARIQAEHETEQLRLKVESELMAMLESKAKTQFNPPENKYSHATEEIYCSVEDLNARNAR 156

Query: 190 LPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDIS 249
            P    +P     +  E    ++S+        + +        ++ +     +   + +
Sbjct: 157 KPSVATQPMRGALK--ELSFNKVSERVRNWEHRVMEERTSEIYNKMKNKKEEEERQAEEA 214

Query: 250 GPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP------PRLSAGNPKSAKPLSME 303
                +     +  + + E   +      REE  R        P      P S+KP S +
Sbjct: 215 DKKQDIVWREQKQKAKEVELQIRQIARQAREEHRRSLLNTSEKPSNVVFVPNSSKPPSKK 274

Query: 304 PSSPL--GEWTDPALPLEN-----QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
                   +        E        W+HG I+R +AE LL      S+LVR SE     
Sbjct: 275 AVVEWFRAKEIPRRAGFEKDKNAIATWFHGLITRQEAEILLINEPVGSFLVRLSERIWG- 333

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           ++++ K      H  +  +  H   LG N    +++ E+V ++ S  +   G E   LL 
Sbjct: 334 YAITYKDHDCCKHYLVDASNGHYQFLGTNQISHNTLSELVSYHRSMPITKTGEE--LLLR 391

Query: 417 PVAIRT 422
           P    T
Sbjct: 392 PCNRTT 397


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =   99 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 49/223 (21%), Positives = 81/223 (36%), Gaps = 12/223 (5%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP 251
           + + R  EE   P E + + + K   +   +           +L +   L     +  GP
Sbjct: 277 QQELRNEEENTHPRE-RVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGP 335

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
             P P   L+D        E+     GR     +     +G  +           PL   
Sbjct: 336 GEPPPVLLLQDDRHSTSSSEQEREG-GRTPTLEILKSHISGIFRPK----FSLPPPLQLI 390

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
            +   PL  Q+WYHGAI R +   LL       +LVR S+  K ++ LS+       H  
Sbjct: 391 PEVQKPLHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQ-GKQEYVLSVLWDGLPRHFI 447

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
           +    ++ Y L      F S+P ++ H  S + P+     + L
Sbjct: 448 IQSL-DNLYRLEGEG--FPSIPLLIDHLLSTQQPLTKKSGVVL 487


>UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Euteleostomi
           RepID=SH24B_HUMAN
          Length = 431

 Score =   99 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 3/100 (3%)

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
            W+HG ISR DAE LL    E ++LVR SE     ++LS +  +GF H  +  + +    
Sbjct: 324 PWFHGIISREDAEALLENMTEGAFLVRVSEKIWG-YTLSYRLQKGFKHFLVDASGDFYSF 382

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           LG +    +++ ++V  +    + + G E   L  P   R
Sbjct: 383 LGVDPNRHATLTDLVDFHKEEIITVSGGE--LLQEPCGQR 420


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score =   99 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 28/115 (24%), Positives = 54/115 (46%), Gaps = 7/115 (6%)

Query: 295 KSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSE-- 351
           KS    S      L E          + W+H  +SR++AE +L+  + + ++L+R SE  
Sbjct: 627 KSNPLKSPTFEQVLAEPVPQQNSHLGKAWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQN 686

Query: 352 TSKND--FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           T      +++S ++     H ++   +  +Y +G  S  F S+ E+V +Y +  L
Sbjct: 687 TKAGQKNYAISFRAEGKVKHCRIEVDESGQYCIG--SAIFDSLTELVQYYEANPL 739



 Score = 91.5 bits (225), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 7/108 (6%)

Query: 320 NQVWYHGAI--SRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
            + W+HG +   R  AE LL   K+   ++LVR S T   D+SLS      + H ++   
Sbjct: 541 KEKWFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTTFTGDYSLSFVRDGKYNHCRIHTK 600

Query: 376 KEHKY--VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
            E         +   F S+ E++ HY S  L     E + L  PV  +
Sbjct: 601 SEGGKTRFYLIDQTLFDSIYELIMHYKSNPLKSPTFEQV-LAEPVPQQ 647


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score = 99.6 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 30/152 (19%), Positives = 55/152 (36%), Gaps = 8/152 (5%)

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL----SMEPSSPLGEW 311
           P  +   +   F G  +  L   + +   +       N   AK       + P++ + + 
Sbjct: 9   PSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKR 68

Query: 312 --TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
                   L    W+HG I+R  AE LL   +   +LVR S     D++L +       H
Sbjct: 69  EGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEH 128

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
            ++        +       F ++ ++V HY S
Sbjct: 129 YRIMYHASK--LSIDEEVYFENLMQLVEHYTS 158


>UniRef50_UPI000180B9A8 PREDICTED: similar to Protein vav-2 n=1 Tax=Ciona intestinalis
           RepID=UPI000180B9A8
          Length = 938

 Score = 99.2 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 52/252 (20%), Positives = 91/252 (36%), Gaps = 12/252 (4%)

Query: 155 ETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISK 214
             A +   LY  P          +      P + +  E    PP    QP +        
Sbjct: 572 SKAVRASRLY-PPNAGSSGPEVPQRGKRTRPFDKKPMEAPSIPPSIPTQPLKAAAAVPPP 630

Query: 215 AFAVDIKVIKDLPWPPPVGQLD---SSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPE 271
                 +     P PP  G +    SS      D +++         +  D    F    
Sbjct: 631 TMYRAHRDYNGNPRPPFPGVMTISFSSHEYVMVDEEVNSDWWLGHTTTDLDRKGYFPASF 690

Query: 272 KSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
            S ++       R    + +   +  +  +  P +P  +    A+PLE  +WY G + R 
Sbjct: 691 VSPVTTKSSRPERSNNDIQSVPGEFPRRSNHPPVTPPQQ----AIPLEENIWYAGTMDRG 746

Query: 332 DAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSS 391
           +AENLL      ++LVR   T     ++SL  S+   H++++R+ E  Y + +    F S
Sbjct: 747 EAENLLHDKPSGTFLVR---TRDGHLAISLIYSKEMKHIRINRSSEGLYFVAECKN-FKS 802

Query: 392 VPEIVHHYASRK 403
           V E++ +Y    
Sbjct: 803 VQELIRYYRENS 814


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score = 99.2 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 26/112 (23%), Positives = 55/112 (49%), Gaps = 4/112 (3%)

Query: 290 SAGNPKSAKPLSMEPSS--PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
           S+G+  +    S+ P++  P    +   + L    W+HG+I+R +AE+LL+  ++  +LV
Sbjct: 649 SSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLV 708

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           R S     D++L +       H ++   +    +   +   F ++ ++V HY
Sbjct: 709 RESTNFPGDYTLCVCFQSKVEHYRVKYLENK--LTIDDEEYFENLGQLVAHY 758


>UniRef50_O14544 Suppressor of cytokine signaling 6 n=31 Tax=Euteleostomi
           RepID=SOCS6_HUMAN
          Length = 535

 Score = 99.2 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 78/449 (17%), Positives = 152/449 (33%), Gaps = 47/449 (10%)

Query: 3   QEGGPVRS-APCRTGTLE---GSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCA 58
           ++GG  RS +    GTL+    ++Q S G  K  +P GS +     S    P       A
Sbjct: 61  EKGGKNRSKSESLMGTLKRRLSAKQKSKG--KAGTPSGSSADEDTFSSSSAPIVFKDVRA 118

Query: 59  HREPISS--------SPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLA--ILEDY 108
            R PI S        SP P    P   +++  +    +R+  L     P P    + +D+
Sbjct: 119 QR-PIRSTSLRSHHYSPAPWPLRPTNSEETCIK--MEVRVKALVHSSSPSPALNGVRKDF 175

Query: 109 ADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPY 168
            D        E +     +     +   +++ +    +       ++     +PL     
Sbjct: 176 HDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGL---MPQDYIQYTVPL----- 227

Query: 169 EPEEDGATAEGEGAPWPRESRLPEDDER-PPEEYDQPWEWKKERISKAFAVDIKVIKDLP 227
              ++G         +  +S  P +    PP+   + +   + ++ +   V  ++  D  
Sbjct: 228 ---DEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQS 284

Query: 228 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP- 286
               +                  P      P ++++  Q      +       E  R   
Sbjct: 285 VNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHL 344

Query: 287 ---PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEA 343
              P  + G  +    +       +   T+    L  Q WY G I+R +AE  L    + 
Sbjct: 345 NFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDG 404

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQ-NSPPFSSVPEIVHH---- 398
           S+LVR+S   +   SLS +S    +H ++  +        Q +    +S+ +++ H    
Sbjct: 405 SFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRD 464

Query: 399 -------YASRKLPIKGAEHMSLLYPVAI 420
                  Y+  +LP      + L  PV+ 
Sbjct: 465 SENGAFCYSRSRLPGSATYPVRLTNPVSR 493


>UniRef50_A9UNJ0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UNJ0_MONBE
          Length = 931

 Score = 99.2 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 41/215 (19%), Positives = 82/215 (38%), Gaps = 12/215 (5%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP 251
           E    P  E   P  W+    S    V +           +  +D    +      ++ P
Sbjct: 488 ESVSDPAGEDGYPHRWRLMDTSGKKPVPLLTFGSYHEATKMRWMD---MIRGKMLAVATP 544

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
           ASP P  +          P  +  SP           + +G  +         S P+   
Sbjct: 545 ASPPPLRAR----MSLRAPNGASSSPKPRRSLSESAAVGSGLARPPSSPRPVLSPPIVGP 600

Query: 312 TDPALPL-ENQVWYH-GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
             P   + +++ W+  GA S +++E  L+   + ++LVR S + +  +SL++       H
Sbjct: 601 RVPRNSVADDEAWFLPGAASLSESE--LKDLPDGTFLVRESTSRQGSYSLTVVFQNEVKH 658

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +K+ R    +Y L +++  F +V ++V  +  + L
Sbjct: 659 IKILRDGT-QYRLTEHAEGFDTVQQLVAFFQRQNL 692


>UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_DROER
          Length = 220

 Score = 99.2 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 27/99 (27%), Positives = 50/99 (50%), Gaps = 4/99 (4%)

Query: 323 WYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    +   +
Sbjct: 52  WFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDL 111

Query: 382 LGQNSPPFSSVPEIVHHYASR-KLPIKGAEHMSLLYPVA 419
            G     F+++PE+V +Y    +L  K  + + L  P+ 
Sbjct: 112 YG--GEKFATLPELVQYYMENGELKEKNGQAIELKQPLI 148


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            NQ W+H  ISR + E LLR   + ++LVR S     DF+L +       H ++ +T   
Sbjct: 144 NNQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSGG 203

Query: 379 KYVLGQNSPPFSSVPEIVHHYAS 401
           + +       FS++ ++V HY  
Sbjct: 204 Q-LTCDKEEYFSNLTQLVSHYKR 225


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 47/205 (22%), Positives = 79/205 (38%), Gaps = 14/205 (6%)

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDG-DRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGR 279
           K  K LP  P   Q+  SP L       +S P  P+PE     +   F G E   L   +
Sbjct: 157 KEKKPLPPTPDQNQVMPSPQLHKNCPSALSRPLPPVPEFQQVVAKFDFPGIEAQDLPLVK 216

Query: 280 EEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL--PLENQVWYHGAISRTDAENLL 337
                +    +    ++      E   P   +  P     LE   W+   I+R  AE LL
Sbjct: 217 GCTYVILDDKNPHWWRAQDEEGREGLIP-STYVYPLTRFDLEQNRWFCKDITRAKAEQLL 275

Query: 338 RL-CKEASYLVRNSETSKNDFSLSLKS---SQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
           R    E S+LVR S +     ++S+ S    +   H  + +    ++ L +    FS++ 
Sbjct: 276 RQAGSEGSFLVRES-SQVGKLTVSVYSCIPCEVVKHYHVKQLPTGEWYLAEKH-TFSTIS 333

Query: 394 EIVHHYASRKLPIKGAEHMSLLYPV 418
           +++H++      +       L +PV
Sbjct: 334 DLIHYHQHNAAGLVTR----LRHPV 354


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 58/313 (18%), Positives = 106/313 (33%), Gaps = 29/313 (9%)

Query: 116 ETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTP--YEPEED 173
              EG        + + +N    +P+  +  +   R         L LYD P    P+  
Sbjct: 191 CCKEGQLRYLLVDDTISDN----QPHWQRCRLLVRRIRDSQEKYVLELYDPPKASSPKLT 246

Query: 174 GATAEGEGAPWPRESRLPEDD---------------ERPPEEYDQPWEWKKERISKAFAV 218
              ++ +         +P++                E   ++    W  + +        
Sbjct: 247 SQCSDIQEVRRCNRLEMPDNINTFVLKVVRQGSWIFETDNDQQVSSWTTEIKECVNNRDT 306

Query: 219 DIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGP-EKSCLSP 277
           ++           +     SP  P           PLP      + A   G  E    S 
Sbjct: 307 EVASCLSGAAAFNLQNSAVSPRCPSTSSSAGADVEPLPTTPDFTAPAGHRGSAELGGQSK 366

Query: 278 GREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL 337
            R  +          + + A P S+ P  P  + TD    L +  W+HG ISR  A +L+
Sbjct: 367 TRSSRPGSGFLGLIPSLRPADPASLPPPEPAVQKTDHF--LFSYPWFHGPISRVKAAHLV 424

Query: 338 RLCK---EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
           +         +LVR SET + D+ L+        H++LS T+  +  +      F SV +
Sbjct: 425 QSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAKHLRLSLTEWGQCRV--QHLRFPSVMD 482

Query: 395 IVHHYASRKLPIK 407
           ++ H+    +P++
Sbjct: 483 MLSHFRLYPIPLE 495


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 6/105 (5%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNS-ETSKNDFSLSLKSSQGFMHMKLSRT 375
           PL  + W+HG + R +   LL    +  +LVR +    ++   LS+  + G  H  +  T
Sbjct: 104 PLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWN-GHKHFIVQTT 160

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            E  +      PPF+S+ E++ H    +LP+       L  PV  
Sbjct: 161 GEGNFRF--EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCR 203


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 53/104 (50%), Gaps = 4/104 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR-KLPIKGAEHMSLLYPVA 419
           +   + G     F+++PE+V +Y    +L  K  + + L  P+ 
Sbjct: 61  DFFDLYG--GEKFATLPELVQYYMENGELKEKNGQAIELKQPLI 102


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 45/252 (17%), Positives = 96/252 (38%), Gaps = 25/252 (9%)

Query: 190 LPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLP------------WPPPVGQLDS 237
           L +  E+  ++   PW+ +++ I K   +   V ++                  +  +  
Sbjct: 447 LSQPVEKNEKQLPSPWQLRRKIILKHKKLPDGVDENSVVIRNEDGAFIHILNGKLFYMCV 506

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA 297
           +    D    +      L +P   + +  F    ++ L      +G         + ++ 
Sbjct: 507 TGREMDLRNTVKNGILYLEDPIDNEWNPHFFVLTQNKLLYTDSFQGNNETDTEDDDEETG 566

Query: 298 --KPLSMEPSSPLGEWTDPALPLE-NQVWYHGAI--SRTDAENLLR---LCKEASYLVRN 349
             +   +   +     + P   L  +++W+HG +   R +AE+LL+      + ++LVR 
Sbjct: 567 FQRHKEVNKFTFSISLSVPNDELHFSEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRE 626

Query: 350 SETSKNDFSLSLKSSQGFMHMKLSRTKEH---KYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           SET   D+SLS        H ++   ++    KY L  ++  F S+  ++ +Y S  L  
Sbjct: 627 SETFVGDYSLSFWRQGKVNHCRIRSKQDKGQTKYYLI-DTNSFDSLYSLITYYRSHPLR- 684

Query: 407 KGAEHMSLLYPV 418
                + L  PV
Sbjct: 685 SQEFLIVLKEPV 696



 Score = 94.6 bits (233), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 8/113 (7%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQG 366
           L E        E + WY   ++R+ AE +L+    + ++LVR SE   N +++S ++ + 
Sbjct: 692 LKEPVPQPNKHEGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRPSERGANSYAISFRAEKK 751

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
             H ++ +     Y +G  S  F S+ +++ +Y    L     + + L +PV 
Sbjct: 752 IKHCRI-KVDGRLYAIG--SVYFESLVDLITYYERHPL----YKKIRLCHPVN 797


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score = 98.8 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 26/111 (23%), Positives = 53/111 (47%), Gaps = 6/111 (5%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSL--SLKSSQGF 367
           +       ++   +YHG I RTD E LL+  KE  +L+R +E +  +  L  S++ +   
Sbjct: 11  DSVSITDDVKGADYYHGLIPRTDIEPLLK--KEGDFLLRKTELTPGEIVLAISVRHNNAV 68

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            H  +++ ++  +    +     SV +++ +Y S K P+  +    L  P+
Sbjct: 69  RHFMVNQDQDGSFYCEHHHEK--SVSDLIQYYKSTKEPLSASSQARLRRPI 117


>UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Takifugu rubripes
           RepID=UPI00016E9884
          Length = 843

 Score = 98.5 bits (243), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 49/242 (20%), Positives = 83/242 (34%), Gaps = 19/242 (7%)

Query: 196 RPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPD---GDRDISGPA 252
           R   +     E K+++ S+         +  P   P           +    + D+S   
Sbjct: 65  RSQSQKKSCREMKQKKTSRPLPCTPAPGRPSPLTSPADHCRKPLDHTEVLWTETDVSDTN 124

Query: 253 SPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT 312
           S + +PS    +A  +   +         KG              K     PS  L +  
Sbjct: 125 SCVRKPSNMTKAASPQDLIED--PHEDNLKGSADTSGDYVKFSKDKFWLEPPSENLKKQL 182

Query: 313 DPAL-----PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
           D  L      L++  WYHG +    AE+L+       +L+R+S ++  DF L+    Q  
Sbjct: 183 DDELRLSGTNLKSHAWYHGPVPWEVAESLV--VNHGEFLIRDSRSNHGDFVLTCHWQQKT 240

Query: 368 MHMKLSRT------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +H  + RT         +         F S+P +VH Y   K  +       +  P+  R
Sbjct: 241 LHFLIRRTVLQSSETYTRVQYSLEEEAFDSLPALVHFYVGSKAALTQWSGAQIHRPIN-R 299

Query: 422 TL 423
           TL
Sbjct: 300 TL 301


>UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicini
           RepID=B0WI58_CULQU
          Length = 825

 Score = 98.5 bits (243), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 23/117 (19%), Positives = 49/117 (41%), Gaps = 14/117 (11%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  +  L +  WYHG I R  AE +++  KE  +LVR+  +   ++ L+ ++    +H
Sbjct: 45  ELSLDSRDLRSHAWYHGPIPRQRAEEIVQ--KEGDFLVRDCVSQPGNYVLTCRTKGPTLH 102

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             +++      T   +         + +VP+++  Y         A    + +P   
Sbjct: 103 FVINKLLIQPETVYERVQYQFEDDAYDTVPDLITFYVGS------ASGARIQFPCNR 153


>UniRef50_UPI0000D9F428 PREDICTED: similar to Src homology 2 domain containing E n=1
           Tax=Macaca mulatta RepID=UPI0000D9F428
          Length = 199

 Score = 98.5 bits (243), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 43/84 (51%), Positives = 56/84 (66%), Gaps = 5/84 (5%)

Query: 139 EPYE---AQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDE 195
           EP E     + +A+ R SK+   +P  LYDTPYEP E G  AEG+    P +SRLPE+DE
Sbjct: 43  EPAEGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGGPRAEGKA--RPPDSRLPENDE 100

Query: 196 RPPEEYDQPWEWKKERISKAFAVD 219
           RP  EY+QPWEWKKE+I +A + +
Sbjct: 101 RPAAEYEQPWEWKKEQIVRALSGE 124


>UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DE57
          Length = 699

 Score = 98.5 bits (243), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 1/82 (1%)

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W HG ISR +AENLL      S+LVR S++    + L+ +      H  +      +YV+
Sbjct: 590 WLHGMISRREAENLLIDKPLGSFLVRISQSRPG-YILTYRGEGRCRHYMIQVQPNARYVI 648

Query: 383 GQNSPPFSSVPEIVHHYASRKL 404
                  +S+ E+V ++ S  +
Sbjct: 649 LGEDRAHASLTELVRYHQSVGI 670


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score = 98.1 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 54/207 (26%), Positives = 80/207 (38%), Gaps = 18/207 (8%)

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
           D  WP        +P   D + D   P   LP          F          G E   R
Sbjct: 17  DKIWPAGGEPDHGTPGSLDPNTD---PVPTLPAEPCSPFPQLFLALYDFTARCGGELSVR 73

Query: 285 LPPRLSA----GNPKSAKPLSMEPSSPLGEWTDPAL----PLENQVWYHGAISRTDAENL 336
              RL A    G    A+ LS +PS+ L   T  A      L +Q WY   +SRT A+ L
Sbjct: 74  RGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQL 133

Query: 337 LRLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
           L        ++L+R SE+S   +SLS+++     H ++S   +    L Q    F  + E
Sbjct: 134 LLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYL-QKGRLFPGLEE 192

Query: 395 IVHHYASRKLPIKGAEHMSLLYPVAIR 421
           ++ +Y +    I+      LL P   +
Sbjct: 193 LLTYYKANWKLIQN----PLLQPCMPQ 215


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score = 98.1 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 2/90 (2%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
            + ++   W+    SR+ AE LLR      +++R  ++S  +FS+S++      H K+ R
Sbjct: 50  YIEIQTPRWFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFKVMR 109

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
               +Y L   S  F+S+ ++V  Y +  +
Sbjct: 110 DSRGQYFLW--SEKFTSLNKLVDFYRTSSI 137


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score = 98.1 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 12/118 (10%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM---HMKLS 373
            L+   W+ G I+R  AE LL   +   +LVR S     D++L + S Q      H ++ 
Sbjct: 26  ELDLANWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 85

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASR--------KLPIKGAEHMSLLYPVAIRTL 423
            T +++  + +++  F ++ E++ HY           K P+K    M L   +   + 
Sbjct: 86  STNDNRVTVDEDAF-FPNLIELIKHYERDADGLCTMLKKPLKKKTEMVLQSAIFKESF 142


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score = 98.1 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 38/140 (27%), Positives = 60/140 (42%), Gaps = 8/140 (5%)

Query: 284 RLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEA 343
           R PP+L   +   A+   +  +        P   L  + W+HG +SR +AE LL+L    
Sbjct: 310 RNPPKLVTPHDSLARSCLLLQARSSSCM--PGHRLRGEPWFHGKLSRREAEALLQL--NG 365

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
            +LVR S T+   + L+   S    H+ L    E   V+      F SV  ++ ++    
Sbjct: 366 DFLVRESTTTPGQYVLTGLQSGQPKHLLLV-DPEG--VVRTKDHRFESVSHLISYHVDNH 422

Query: 404 LPIKGA-EHMSLLYPVAIRT 422
           LPI  A   + L  PV  + 
Sbjct: 423 LPIISAGSELCLQQPVERKL 442


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score = 98.1 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 8/135 (5%)

Query: 290 SAGNPKSAKPLS---MEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
           +AG   ++ PL      P +           L  + WYHG +SR  AE LLR   +  +L
Sbjct: 442 AAGITAASPPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSRRAAEKLLR--ADGDFL 499

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           VR+S T+   + L+   +    H+ L    E   V+      F S+  ++ ++    LPI
Sbjct: 500 VRDSVTNPGQYVLTGMHAGQPKHLLLV-DPEG--VVRTKDVLFESISHLIDYHLKNGLPI 556

Query: 407 KGAEHMSLLYPVAIR 421
             AE    L  V  R
Sbjct: 557 VAAESELHLRGVVSR 571


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score = 97.7 bits (241), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 6/104 (5%)

Query: 320 NQVWYHGAISRTDAENLL---RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           +  WYHG ISR  AE +L      ++  +LVR S ++  D+ L +  +   +H ++ R  
Sbjct: 9   DINWYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQNNEVVHYQIRRHG 68

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           E  +           +  ++ HY     P   +  + L  P+  
Sbjct: 69  EDAFFSIDEQNIMHGLETLIEHYCKVNDP---SLGVQLSKPIVK 109



 Score = 85.7 bits (210), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 24/94 (25%), Positives = 41/94 (43%), Gaps = 5/94 (5%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQG 366
           L E+  P        WYHG + R +A  +L+    +  +LVR +  S   + LS+  +  
Sbjct: 275 LNEFVSPMPSSRKDQWYHGKLDRHEATAILKTKDVDGCFLVRMNRQS--GYVLSMMCTNQ 332

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
             H ++      KY    N P  +S+  ++ HY 
Sbjct: 333 CYHFQIQ--DRDKYYFIDNGPYLNSLEHLIQHYT 364


>UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7Q1P4_IXOSC
          Length = 461

 Score = 97.7 bits (241), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 6/104 (5%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LE + W+HGAISR ++E  L   ++  +LVR S+ +   F L+        H+ L     
Sbjct: 361 LEKEAWFHGAISRKESEGRL--AEDGDFLVRESQGNPGQFVLTGMQGSARRHLLLVDPAG 418

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH-MSLLYPVAI 420
              V+      F SV  +V+++    LPI  AE  + L  PV  
Sbjct: 419 ---VVRTKDRTFDSVSHLVNYHRDNALPIISAESALVLKNPVPR 459


>UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Nasonia vitripennis
           RepID=UPI00015B5D64
          Length = 858

 Score = 97.7 bits (241), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 39/172 (22%), Positives = 62/172 (36%), Gaps = 26/172 (15%)

Query: 274 CLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE--------------WTDPALPLE 319
           C     EE   LPPR SA     + P +     P+ E                DP   L 
Sbjct: 106 CRDQEHEEPLLLPPRGSAPASGCSSPRASMSQEPVEESVRKLLERELRLFDLIDP-RDLR 164

Query: 320 NQVWYHG---AISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR-- 374
           +  WYHG      R  AE    +  +  +LVR+  +   ++ LS++     +H  +++  
Sbjct: 165 SYAWYHGSSLPGGRKGAEA--EIPNDGDFLVRDCSSQPGNYVLSVRHKGQALHFVINKLV 222

Query: 375 ----TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
               T   +         F +V ++V  Y   K PI  A    ++ P   R 
Sbjct: 223 LQPDTVYERVQYQLEDEAFDTVADLVTFYVGSKRPISQASGARIVNPRHRRL 274


>UniRef50_B0XFC9 Phosphatidylinositol 3-kinase regulatory subunit n=3 Tax=Culicini
           RepID=B0XFC9_CULQU
          Length = 872

 Score = 97.3 bits (240), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 44/224 (19%), Positives = 81/224 (36%), Gaps = 9/224 (4%)

Query: 201 YDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE--- 257
           Y   W+ K        AV  +               S  S        +    P P    
Sbjct: 364 YKLDWKEKLPEFLSTPAVPPRKTSRSTGVGSASSSLSLSSTSSSSTSTTVTQQPQPSAAG 423

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
            SL+  SA       + + P     G +    +     + +   M  +  +G+   PA  
Sbjct: 424 GSLKKPSAIQSPAGPTAVIPSPLADGAVGTYNNTNGVDAVR--GMRGTMAVGDADTPA-D 480

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L    WY G ISR +A+  +   ++ S+LVR++ +   +++L+LK       +K+     
Sbjct: 481 LREAEWYWGRISRDEAKEKMTDVQDGSFLVRDATSGGGEYTLTLKKDGTDRVIKIYHC-N 539

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVAI 420
            +Y   +     +SV E++  Y    L        + L+YP++ 
Sbjct: 540 GRYGFTKECN-HASVVELIAFYKRESLKEYNTILDIKLMYPISR 582



 Score = 71.5 bits (173), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 34/151 (22%), Positives = 60/151 (39%), Gaps = 8/151 (5%)

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV-WYHGA 327
            PE   LS  ++       RL   + +  + L+    S         LP E++  W   A
Sbjct: 718 NPELMTLSKTKDHYLEHLHRLKFTDGEIKQMLADGNWSAAP---SSNLPHEDETTWLKIA 774

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
            +R  AE  L      ++L+R        F+LS+  ++   H  + +T+   Y   +   
Sbjct: 775 YNRQQAEQELAGRPTGTFLIRG--RVGGQFALSITCNETVNHCIIHQTERG-YGFAEPYN 831

Query: 388 PFSSVPEIVHHYASRKLPIKGAE-HMSLLYP 417
            + S+ ++V HYA+  L         +L YP
Sbjct: 832 IYGSLKQLVLHYANNSLEEHNDTLQTTLKYP 862


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score = 97.3 bits (240), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 1/82 (1%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
             WYHGA+SR   E+LLR     S+LVR SE++    S++++      H ++S+     +
Sbjct: 239 YSWYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLF 298

Query: 381 VLGQNSPPFSSVPEIVHHYASR 402
            + +    F +V +++ H++  
Sbjct: 299 YITEAH-RFPTVVQLIEHHSRS 319


>UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE
          Length = 321

 Score = 97.3 bits (240), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 29/119 (24%), Positives = 59/119 (49%), Gaps = 4/119 (3%)

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN-SETSKNDFSLSL 361
                L    +P+  L++  WY   ISR +   +L    + ++LVR+ S   + +++L++
Sbjct: 12  STDDHLQTQREPSDLLQDAEWYWADISREEVNEILHGMPDGAFLVRDASCKVQGEYTLTV 71

Query: 362 KSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVA 419
           +++     +++   +E K+   +    FSSVPE++  Y +R L        ++L YPV 
Sbjct: 72  RNNGTNKLIRILH-QEGKFGFSEP-LTFSSVPELISFYRNRSLVHYNTSLDVTLAYPVT 128



 Score = 89.2 bits (219), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 28/102 (27%), Positives = 49/102 (48%), Gaps = 3/102 (2%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L  + W+ G ++R  AE LL      ++L+RNS +SK+ ++ S+  +    H  +  T+ 
Sbjct: 214 LREESWFVGDLARGPAEELLLGKPNGAFLIRNS-SSKDCYACSVVVNSQVRHCVIRHTER 272

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
             Y   +      S+ ++V HY+   L     A  + L YPV
Sbjct: 273 G-YGFVEPFDLHKSLKDLVLHYSQTSLAQHNQALDVRLAYPV 313


>UniRef50_UPI000179134F PREDICTED: similar to signal transduction protein lnk-realted,
           partial n=1 Tax=Acyrthosiphon pisum RepID=UPI000179134F
          Length = 474

 Score = 96.9 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 43/245 (17%), Positives = 86/245 (35%), Gaps = 30/245 (12%)

Query: 168 YEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLP 227
           Y P +   +  G      +++R  ++ E P E Y   +  K E   +     +   +   
Sbjct: 167 YCPPKSLKSKHGVFCFLIQDARETKEIEMP-ERYANTFVLKDENNVEYIIDALSPEEMRQ 225

Query: 228 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP 287
           W   V            D  I G                 +G   S ++   +     P 
Sbjct: 226 WLATVKYCMRKRDGLHDDISIIGSI---------------DGVLDSSVAHSNDTLLSSPQ 270

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL---LRLCKEAS 344
                    +   +++         D +  L    W+HG ++R+DA NL   L       
Sbjct: 271 ---------SSTNNLDTILNNDVENDISASLRLYPWFHGMLARSDATNLVSHLGTNGHGM 321

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +LVR SET K ++ L+        H++++   +    +   S  F S+ +++ H+ +  +
Sbjct: 322 FLVRQSETRKGEYVLTFNFKGKPKHLRMTLNDQGHCRVQHLS--FPSIQDMLEHFQTHLI 379

Query: 405 PIKGA 409
           P++  
Sbjct: 380 PLENG 384


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score = 96.9 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 25/88 (28%), Positives = 46/88 (52%), Gaps = 3/88 (3%)

Query: 317 PLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
            LE   W HGAISR  A+ LL +   +  YLVR S++    ++L +      +H ++++ 
Sbjct: 68  SLELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPGQYTLDVWKEGKSVHYRITKG 127

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRK 403
            E  +   +    F ++PE++ H+ +R 
Sbjct: 128 DEGYFF--RQGVCFPTIPELIQHHQTRS 153


>UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7QIL2_IXOSC
          Length = 372

 Score = 96.9 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 39/175 (22%), Positives = 71/175 (40%), Gaps = 19/175 (10%)

Query: 258 PSLEDSSAQFEGPEKSCLSPGRE---------EKGRLPPR----LSAGNPKSAKPLSMEP 304
             +  +   F+G  KS  S   +            R PP        G         +  
Sbjct: 197 GKIPGTLRTFDGVLKSVFSLECDLGWILVRHVGCRRGPPPSLDPHRGGGSPPPPVPQVVS 256

Query: 305 SSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKS 363
               G+       L  + WY G+I R+  + +L  C ++  +L+R+SET+  D S+SLK+
Sbjct: 257 VVAGGQQPRGRPELRAKEWYFGSIPRSQCDQVLNECAQDGDFLIRDSETNVGDLSVSLKA 316

Query: 364 SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
                H ++   ++  + +GQ    FS + ++V HY   + PI  +     ++ V
Sbjct: 317 PLRNKHFRV-HVEDGVFCIGQR--RFSQLDDLVEHYK--RAPIYTSPKGDKMFLV 366


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score = 96.9 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 43/201 (21%), Positives = 67/201 (33%), Gaps = 8/201 (3%)

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
                 P    V      P   +    ++      PEP        F+       +    
Sbjct: 388 STGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDM-RPFEDALKLH 446

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLC 340
           E        +A  P   +  S  P +           L  + WYHG +SR  AE +LR  
Sbjct: 447 ECSVAAGVTAAPLPLEDQWPS--PPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLR-- 502

Query: 341 KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
            +  +LVR+S T+   + L+   +    H+ L    E   V+      F S+  ++ H+ 
Sbjct: 503 ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLV-DPEG--VVRTKDVLFESISHLIDHHL 559

Query: 401 SRKLPIKGAEHMSLLYPVAIR 421
               PI  AE    L  V  R
Sbjct: 560 QNGQPIVAAESELHLRGVVSR 580


>UniRef50_C3Z699 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3Z699_BRAFL
          Length = 950

 Score = 96.9 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 1/80 (1%)

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
            W+HG I+R ++E LL+      +L+R SE+    +SL+ + S    H  + +    KYV
Sbjct: 776 PWFHGIITRRESERLLQDKLLGCFLIRVSESRFG-YSLTYRISSRCKHFMIDQLPSGKYV 834

Query: 382 LGQNSPPFSSVPEIVHHYAS 401
           +        S+  +V +Y  
Sbjct: 835 VVGEPKVHVSLSALVDYYRK 854


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score = 96.9 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 32/117 (27%), Positives = 49/117 (41%), Gaps = 6/117 (5%)

Query: 305  SSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNS-ETSKNDFSLSLKS 363
            + P         PL  + W+HG + R +   LLR   E  +LVR +    ++   LS+  
Sbjct: 933  NIPPQMTLSTNRPLHEEEWFHGVLPREEVVRLLRN--EGDFLVRETTRNDESQTVLSVCW 990

Query: 364  SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            + G  H  +  T E  Y      P F S+ E++ H    +LP+ G     L  PV  
Sbjct: 991  N-GHKHFIVQTTAEGHYRF--EGPAFPSIQELIVHQYQSELPVTGRSGAVLRKPVLR 1044


>UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR
          Length = 442

 Score = 96.5 bits (238), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 42/194 (21%), Positives = 78/194 (40%), Gaps = 17/194 (8%)

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSA-QFEGPEKSCLSPGREEKGRL 285
           P  P V QL+          ++    SP P+ +    +   F+  ++   +         
Sbjct: 246 PHAPRVAQLNLRKPRDRLSSNLIDLNSPPPDQTTNKLALGNFDPLQQQAAATVAATTATA 305

Query: 286 PPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASY 345
               +A N  S + +          +  P  PL  +VW+H AISR  +E LL+  ++  +
Sbjct: 306 SATAAAPNSHSIRDV----------FDGPQCPLTAEVWFHAAISRPISERLLQ--QDGDF 353

Query: 346 LVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP 405
           LVR S+  +  + L+    +   H+ L    E   V+      F S+  +++++    LP
Sbjct: 354 LVRESQGKRGQYVLTGLEGKAPKHLLLI-DPEG--VVRTKDRIFDSISHLINYHWVHALP 410

Query: 406 IKGAEH-MSLLYPV 418
           I   +  + L  PV
Sbjct: 411 IISEDSELVLRNPV 424


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 8/105 (7%)

Query: 320 NQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL--SRT 375
           ++ W+H  ISR +AE+LL+     + S+LVR S     DFSLS        H  +    T
Sbjct: 319 SEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRKNRVQHCHIKSRPT 378

Query: 376 KEH--KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            +   KY L      F ++  +++HY +  L     E M L  PV
Sbjct: 379 NDGTAKYFLVGPKG-FDNLYSLINHYQTNPLKSDKFELM-LTEPV 421



 Score = 81.5 bits (199), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 10/115 (8%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKND--FSLSLKSS 364
           L E          + WYH  ++R  AE +LR   K++ +LVR       +  +++S ++ 
Sbjct: 417 LTEPVPQPNAHLGKDWYHENLTRLQAEEMLRRMRKDSYFLVRKRNDGDQNESYAISFRTG 476

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
               H  + + +   +++G  + PF S+ E++ HY    L  K      L YP  
Sbjct: 477 GTIKHCVIKK-EGRLFMIG--TAPFESLTELIAHYEKNPLYRKTK----LKYPCN 524


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 49/104 (47%), Gaps = 7/104 (6%)

Query: 319 ENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSK--NDFSLSLKSSQGFMHMKLSRT 375
           ++  WY G ISR  AE  L     + ++++R+SE++    +FSLS+K      H K+   
Sbjct: 58  KSHPWYVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKILTD 117

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
              KY L      F+S+ ++V ++      +   + + L  P  
Sbjct: 118 LAGKYFLWV--VKFTSINDLVDYHKDNS--VSRTQEIVLNEPCV 157


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 30/103 (29%), Positives = 54/103 (52%), Gaps = 5/103 (4%)

Query: 322 VWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
            W+H  IS  +AE LL       S+L R S+++  DF+LS++ +    H+K+  T ++  
Sbjct: 3   RWFHPNISGIEAEKLLLTRGVHGSFLARPSKSNPGDFTLSVRRNDEVTHIKIQNTGDYYD 62

Query: 381 VLGQNSPPFSSVPEIVHHYASRK--LPIKGAEHMSLLYPVAIR 421
           + G     F+  PE+V +Y  ++  L  K +  + L YP+  +
Sbjct: 63  LYG--GEKFARKPELVQYYTEQQGLLREKNSNVIELKYPLNCQ 103



 Score = 78.8 bits (192), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 29/145 (20%), Positives = 51/145 (35%), Gaps = 45/145 (31%)

Query: 320 NQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMH--------- 369
           ++ WYHG ++  +AE LL    K  S+LVR S++   DF LS+ +++  M          
Sbjct: 107 SERWYHGHLTGKEAEKLLTEKGKPGSFLVRESQSKPGDFVLSVLTNEDKMETGDPQTSRD 166

Query: 370 -------------MKLSRT---------------------KEHKYVLGQNSPPFSSVPEI 395
                         + +                        + KY +G     F ++ ++
Sbjct: 167 PRDDPLPGGQPACPRFACRAGPSWEPCALEPHRASVALLQPDGKYDVGG-GERFDTLTDL 225

Query: 396 VHHYASRKLPIKGAEHMSLLYPVAI 420
           V HY    +  K    + L  P   
Sbjct: 226 VEHYKKNPMVEKSGAVVHLKQPFNA 250


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 36/170 (21%), Positives = 70/170 (41%), Gaps = 14/170 (8%)

Query: 257 EPSLEDSSAQ-FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
           +P+ ++ +   F   E + L    E + +               +    ++     +D  
Sbjct: 505 DPTFKEWNLHYFVLTEDNKLVYTEERQTQPHD----DTTSEDGSIDESANNDRRGSSDTT 560

Query: 316 LPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL- 372
                + WYHG + R +A+ LLR    K+ S++VR S T   + +LS        H ++ 
Sbjct: 561 ELHYAEKWYHGQMGRDEADQLLRDYNGKDGSFMVRESATFIGNCTLSFMYHGRVTHCRIH 620

Query: 373 -SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE---HMSLLYPV 418
             +   H Y    ++  F S+  +V HY  ++ P++ A+    + L  PV
Sbjct: 621 SQQNNGHTYFYLVHALLFDSLYSLVWHY--QRYPLRNAKMNFELLLTEPV 668



 Score = 84.2 bits (206), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 11/126 (8%)

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSET-- 352
             +   M     L E         N+ WYH +++RTDAEN+L R+ ++ ++LVR   +  
Sbjct: 652 PLRNAKMNFELLLTEPVPQPNAHANKEWYHDSMTRTDAENVLMRIPRDGAFLVRKCRSDD 711

Query: 353 -SKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH 411
            S   F++S ++     H ++ + +   +V+G  +  F ++ +++  Y    L       
Sbjct: 712 PSVTSFAISFRADGKIKHCRIKQ-ESRLFVIG--NATFETLCDVISFYEKNPL----YRK 764

Query: 412 MSLLYP 417
           M L +P
Sbjct: 765 MKLKHP 770


>UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B2C65
          Length = 846

 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 49/288 (17%), Positives = 85/288 (29%), Gaps = 58/288 (20%)

Query: 173 DGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPV 232
            G   E +  P  R        E        P                +     P    V
Sbjct: 45  PGGQPEDQVQPCLRSPGYAHSSEMYTHVGTAPR---------------RSSPLTPEAQHV 89

Query: 233 GQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKG----RLPPR 288
            Q D     P      SG  +  P+         +EG      +P +  +G    + P  
Sbjct: 90  SQADGCVRKPSNMAA-SGAKAASPQDLYVPMDPIYEGAHTHKSAPTKSPRGVALKQEPDV 148

Query: 289 LSAGNPKSAKPLSM-----EPSSPLGEWT-------------------------DPALPL 318
           L    P+   P  M       +   GE+                            +  L
Sbjct: 149 LEPTAPEEKSPPFMFFSLTGSADSSGEYVKFSKGKFWLEPLSENLKKQLEEELRLSSTNL 208

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR---- 374
           ++  WYHG I    +E+L+       +L+R+S++++ +F L+    Q  +H  + +    
Sbjct: 209 KSHAWYHGPIPWEVSESLV--VNHGDFLIRDSQSNRGNFVLTSNWQQKTLHFLIRKAALQ 266

Query: 375 --TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
                 +         F S+P +VH Y   + P+       +  PV  
Sbjct: 267 PGETYPRVQYSLEEEAFESLPALVHFYVGSRAPLTQWSGAQIQRPVNR 314


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score = 96.5 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 40/195 (20%), Positives = 72/195 (36%), Gaps = 5/195 (2%)

Query: 216 FAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCL 275
           F    +      WP          + P        PASP+    +  + +  +       
Sbjct: 281 FEAGDEQPFKPGWPRSGKLAKLESACPQMLCPALIPASPIHAGQMWVTLSSCQAGTPIPQ 340

Query: 276 SPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN 335
            P          ++S    +     +M    P          L +  W+HG ISR  A  
Sbjct: 341 PPALLPAPTPQAKVSTRGHQEQGRGAMPGGPPEAAGPKMEQFLSSCPWFHGPISRVKAAQ 400

Query: 336 LLRLCK---EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSV 392
           L++L        +LVR SET + ++ L+        H++LS T+  +  +      FSS+
Sbjct: 401 LVQLGGLEGHGVFLVRQSETRRGEYVLTFNFQGRAKHLRLSLTERGQCRV--QHLRFSSI 458

Query: 393 PEIVHHYASRKLPIK 407
            E++HH+    +P++
Sbjct: 459 TEMLHHFHRYPIPLE 473


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score = 96.1 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 57/150 (38%), Gaps = 9/150 (6%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
           +L  +   +E      L   + E+ R+    S    K+    + +       +   A  L
Sbjct: 122 NLVIALHSYEPSHDGDLGFEKGEQLRILE-QSGEWWKAQSLTTGQEGFIPFNFVAKANSL 180

Query: 319 ENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQG-----FMHMK 371
           E + W+   +SR DAE  L        S+L+R SE++   FSLS++           H K
Sbjct: 181 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 240

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +       + +      F  + E+V HY  
Sbjct: 241 IRNLDNGGFYIS-PRITFPGLHELVRHYTR 269


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score = 96.1 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 44/226 (19%), Positives = 80/226 (35%), Gaps = 11/226 (4%)

Query: 196  RPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPL 255
            +P ++  +       +    FA + +V +           +  P+     +     +   
Sbjct: 838  KPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHK 897

Query: 256  PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
              P    S    E  ++   +   EE       LS  +     P S+  S  L       
Sbjct: 898  DHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVP-SLAASISLSTN---- 952

Query: 316  LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNS-ETSKNDFSLSLKSSQGFMHMKLSR 374
             PL  + W+HG + R +   LL    +  +LVR +    ++   LS+  + G  H  +  
Sbjct: 953  RPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWN-GHKHFIVQT 1009

Query: 375  TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            T E  +      PPF+S+ E++ H    +LP+       L  PV  
Sbjct: 1010 TGEGNFRF--EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCR 1053


>UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X6G9_CULQU
          Length = 109

 Score = 96.1 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 26/102 (25%), Positives = 51/102 (50%), Gaps = 5/102 (4%)

Query: 321 QVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           + W+H ++S  DAE LL     + S+L R S ++   F+LS++  +   H+K+    +  
Sbjct: 2   ERWFHPSVSGVDAEKLLLERGFDGSFLARLSSSNPGAFTLSVRRGKEVTHIKIQNNGDFF 61

Query: 380 YVLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
            + G     F+++ E+V +Y     +L  K  + + L  P+ 
Sbjct: 62  DLYG--GEKFATLSELVQYYMENGGQLKEKNGQIIELKQPLI 101


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 49/221 (22%), Positives = 80/221 (36%), Gaps = 23/221 (10%)

Query: 188 SRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD 247
           S    D E+P +E D+  +W   ++S       +     P PP V     +P  PD   D
Sbjct: 5   SSKKPDKEKPIKEKDKG-QWSPLKVSA------QDKDAPPLPPLVVFNHLTPPPPDEHLD 57

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
                    +     +   +       L   + EK ++           +     E   P
Sbjct: 58  --------EDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVP 109

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLK--- 362
              +      LE + W+  +  R +AE  L        S+L+R SET+K  FSLS+K   
Sbjct: 110 -SNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT 168

Query: 363 -SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
              +   H K+    E  Y +      F S+  +V HY+ +
Sbjct: 169 TQGELIKHYKIRCLDEGGYYIS-PRITFPSLQALVQHYSKK 208


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 34/148 (22%), Positives = 58/148 (39%), Gaps = 9/148 (6%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   +E      L   + EK ++         K+    + +       +   A  +E + 
Sbjct: 68  ALYPYEAIHADDLGFKKGEKLKIIEEHGEW-WKARSLTTRKEGFIPSNYVAEADTMETEE 126

Query: 323 WYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKS-----SQGFMHMKLSRT 375
           W++  I+R DAE  L     K  SYL+R SETSK  +SLS++           H K+   
Sbjct: 127 WFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHYKIRSL 186

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRK 403
               Y +      FS +  ++ HY  + 
Sbjct: 187 DNGGYYIS-PKITFSDISSMIKHYHKQS 213


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 2/85 (2%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
              W+   I+R +AE LL   +  ++LVR SE+S+  +SLS+K ++   H ++ +    K
Sbjct: 11  AMAWFFPTITRKNAELLLMQERNGAFLVRRSESSEGLYSLSVKYNESVQHFRILQDTAGK 70

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKL 404
           + L      F S+  +V +Y +  +
Sbjct: 71  FHLWI--VKFPSLDALVDYYRTTSV 93


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 34/150 (22%), Positives = 61/150 (40%), Gaps = 3/150 (2%)

Query: 253 SPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT 312
             L + ++  +   F    ++ LS    E+  L         K    L+ +       + 
Sbjct: 30  QCLSQENIYVALFNFTSNNEAELSFSCGEQLELLSISDGSWWKVRSLLTNKIGYIPNNYV 89

Query: 313 DPALPLENQVWYHGAISRTDAE-NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
           +    L+   WY G + R+ A   LL      S+LVR S +   D++LSL +     H  
Sbjct: 90  EKYDYLKKYDWYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGDYTLSLHNETSLKHYH 149

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           + +TK   + + +    FS++P +V HY  
Sbjct: 150 IKKTKNCTFYILKEE--FSNLPSLVEHYKK 177


>UniRef50_A9V1A4 Predicted protein (Fragment) n=1 Tax=Monosiga brevicollis
           RepID=A9V1A4_MONBE
          Length = 634

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/100 (27%), Positives = 52/100 (52%), Gaps = 5/100 (5%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG-FMHMKLSRTKEHK 379
             W+HG +SR +AE+LL      ++L+R S+ S N ++LS+K  +  F H +++      
Sbjct: 509 YPWFHGLLSRREAEDLLYDSPVGTFLLRVSDRSFN-YALSIKHDKAFFRHYRVTHAASGG 567

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGA---EHMSLLY 416
           Y +   +  F ++ E+V  +    L + G    E + L++
Sbjct: 568 YCVDGAASDFPTLAELVDFFRHENLSVAGDRLVEPLDLIH 607


>UniRef50_D2H965 Putative uncharacterized protein (Fragment) n=3 Tax=Amniota
           RepID=D2H965_AILME
          Length = 453

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 59/330 (17%), Positives = 104/330 (31%), Gaps = 37/330 (11%)

Query: 116 ETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLP------------L 163
           +T            +  +N  Y +  E + +    R +     + +P            L
Sbjct: 126 KTKSQYYDLQAPDTQETQNI-YTKAAEEEGLGKGPRPAPLLEEEKIPSLSSSSRNIQQML 184

Query: 164 YDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVI 223
            D+    +  G   + E     ++  L + DE    +  + W   KE      ++     
Sbjct: 185 ADSINRMKAYGFHQKKESVKKTQDEELKQIDEEKTMQIYKSW---KEDSDWQASLRKSKA 241

Query: 224 KDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPS--LEDSSAQFEGPEKSCLSPGREE 281
            D        Q            +  G       P    +        P+   LSP    
Sbjct: 242 ADEKRRSLAKQAREDYKRLSLVAEKGGSNEEPRSPPGVPQKPKRPPLPPKPHFLSPA--- 298

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEW-TDPALPLEN---------QVWYHGAISRT 331
                PR   G     +  S      +  W  +  LPL             W+HG ++  
Sbjct: 299 ---GYPRNPLGKQGVTRTASGSAREDIIRWFKEEQLPLRAGYQRTSDTIAPWFHGILTLK 355

Query: 332 DAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSS 391
            A  LL  C+  S+L+R SE  K  ++LS  S  G  H  +  + +    LG +    ++
Sbjct: 356 RANELLSTCEPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADSYSFLGVDRLRHAT 414

Query: 392 VPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +  +V ++    +   G E   LLYP   +
Sbjct: 415 LAALVDYHKEEPITSLGKE--LLLYPCGQQ 442


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 46/235 (19%), Positives = 85/235 (36%), Gaps = 24/235 (10%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP 251
           +++++   EY          I        +V+ +     P+     S        D S  
Sbjct: 177 KNEDKDSHEY-------YNEIPGKGPSADEVLANRMKTEPMEIKRMSNKHLSFSTDHSAS 229

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
               P+         +        +P + +       +S  N +    L+ +      E 
Sbjct: 230 KVLKPQVGGMFDDPCYINTVPKQDNPSKSQ-------ISGKNKEICDLLASKKFYSTTEI 282

Query: 312 TDPALPL----ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
            +P LPL    +++ WYHG ++R  AE+LL    +  +L+R S TS   + LS       
Sbjct: 283 QEPKLPLYSSLQHEEWYHGKMNRKVAESLL--VNDGDFLIRESTTSACQYVLSGLQGGHP 340

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP-IKGAEHMSLLYPVAIR 421
            H+ L    + K  +      F SV  ++ ++   +LP I     + L  PV  +
Sbjct: 341 KHLLLV-DPDGK--VRTKDHVFESVIHLISYHMENELPIISSGSELYLRKPVRKQ 392


>UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2
           domain-containing-transforming protein C3) (Neuronal
           Shc) (N-Shc) (Protein Rai). n=15 Tax=Euteleostomi
           RepID=UPI0000ECC29C
          Length = 582

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/99 (27%), Positives = 44/99 (44%), Gaps = 6/99 (6%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
            + WY G +SR +AE LL+ C    +LVR S T+   + L+   +    H+ L    E  
Sbjct: 484 EKPWYQGEMSRKEAEQLLKKC--GDFLVRKSTTNPGSYVLTGMQNGQAKHLLLV-DPEG- 539

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPI-KGAEHMSLLYP 417
             +      F S+  +++H+    LPI      + L  P
Sbjct: 540 -TVRTKDRVFDSISHLINHHLENNLPIVSSGSKLCLQQP 577


>UniRef50_P70305 Phosphoinositide 3-kinase p85alpha (Fragment) n=9 Tax=Metazoa
           RepID=P70305_MOUSE
          Length = 112

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 3/87 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMKLSRTK 376
           L++  WY G ISR +    LR   + ++LVR++ T    D++L+L+       +K+   +
Sbjct: 28  LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFH-R 86

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRK 403
           + KY        F+SV E+++HY +  
Sbjct: 87  DGKYGFSDP-LTFNSVVELINHYRNES 112


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 2/105 (1%)

Query: 320 NQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            + W+HG I+  +AE  LL   K   +LVR S      + LS+ + +   H+ +      
Sbjct: 111 TERWFHGKITGKEAEKMLLERGKPDCFLVRESVHRPGSYVLSVLTGEQVAHIMIHGKPNG 170

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            Y +G     FSS+ E++  Y +  +  K    +SL  P      
Sbjct: 171 MYDVGGGHQ-FSSLKELIDFYTNTPMVEKNGGLVSLKQPFNATRF 214



 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/101 (26%), Positives = 51/101 (50%), Gaps = 5/101 (4%)

Query: 322 VWYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
            W+H  ++  +AE LL L     S+L R S ++   F+LS++      H+++  T+E   
Sbjct: 7   RWFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGDEVTHIRIQNTEEFLD 66

Query: 381 VLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
           + G     F+++ E+V +Y     +L  K  + + L YP+ 
Sbjct: 67  LYG--GEKFATLSELVTYYMENEGQLREKNGDLIELKYPLI 105


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score = 95.4 bits (235), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 32/117 (27%), Positives = 55/117 (47%), Gaps = 9/117 (7%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQG 366
           L E        E++ WYH  +SR+ AEN+L     + ++LVR      N F++S ++   
Sbjct: 732 LTEPVPQTNAHESKEWYHANLSRSQAENMLMRVPRDGAFLVRKRA-EPNSFAISFRAEGK 790

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
             H ++ +  E + V+   S  F S+ +++ +Y    L       M L YP+   TL
Sbjct: 791 IKHCRVQQ--EGQTVVLGTSE-FDSLVDLISYYEKHPL----YRKMKLRYPINEDTL 840



 Score = 84.6 bits (207), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 33/113 (29%), Positives = 49/113 (43%), Gaps = 16/113 (14%)

Query: 320 NQVWYHGAIS-----RTDAENLLR------LCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
            + W+HG +      R  AE LL          + S+LVR SET   D++LS   S    
Sbjct: 626 TEKWFHGKLGAGRDGRQIAERLLSEYCMETGAPDGSFLVRESETFVGDYTLSFWRSGRVQ 685

Query: 369 HMKLSRTKEH---KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           H ++   +E    K+ L  N   F ++  +++HY    L     E M L  PV
Sbjct: 686 HCRIHSRQEAGSPKFYLTDN-LVFDTLFALINHYQQVALRCNEFE-MKLTEPV 736


>UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SVT4_TETNG
          Length = 1377

 Score = 95.0 bits (234), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 8/117 (6%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQG 366
           LG         E++ WYH +++R  AE++L     + ++LVR   +  N +++S ++   
Sbjct: 672 LGNPVPQPNAHESREWYHSSLTRVQAEHMLMRVPRDGAFLVRK-RSEHNSYAISFRAEGK 730

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
             H ++ +  E +  +  +S  F S+ ++V +Y    L       M L YP+   TL
Sbjct: 731 IKHCRIQQ--EGRLFMLGSSAEFESLMDLVSYYEKHPL----YRKMKLRYPINEDTL 781



 Score = 85.0 bits (208), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 12/97 (12%)

Query: 320 NQVWYHGAIS-----RTDAENLLR-----LCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            + W+HG +      R  AE LL+       K+ ++LVR SET   D++LS   S    H
Sbjct: 567 AERWFHGKLGGGRDGRQVAEKLLQEYCEGGAKDGTFLVRESETFVGDYTLSFWRSGRVQH 626

Query: 370 MKLSRTKEHK--YVLGQNSPPFSSVPEIVHHYASRKL 404
            ++   +E         ++  F S+  ++ HY    L
Sbjct: 627 CRIHSRQESGSTRFYLTDNLVFDSLYRLICHYRDTPL 663


>UniRef50_UPI0000D56E93 PREDICTED: similar to predicted protein n=1 Tax=Tribolium castaneum
           RepID=UPI0000D56E93
          Length = 412

 Score = 95.0 bits (234), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 40/216 (18%), Positives = 79/216 (36%), Gaps = 15/216 (6%)

Query: 205 WE--WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLE- 261
           WE    +ER  + F    K  + +       +        + +R        + E +   
Sbjct: 196 WEKRLTEERTCEIFQKMQKEQQQVAKEAEEAEQKQEQLWREQERKAKQAEQQIREIARRA 255

Query: 262 DSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQ 321
               +    E           G  P R +                P     D +  +E+ 
Sbjct: 256 REEHRLTNFEIDTSYSTINNTGVPPGRGAVVEWYK------SHERPKWTGLDRSNNVES- 308

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
            W+HG I+R++AE LL      S+LVR SE     +++S ++ +   H  +S   ++++ 
Sbjct: 309 -WFHGLITRSEAEKLLLDRPYGSFLVRLSERIWG-YAISYRAKEKCKHYLVSAGLKYQF- 365

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           LG N     ++ +++ ++     P+ G E +    P
Sbjct: 366 LGNNQIEHETLRDLIEYHRVH--PLTGGEKLVEACP 399


>UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=1 Tax=Ciona intestinalis
           RepID=UPI0000523E1B
          Length = 322

 Score = 95.0 bits (234), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 3/91 (3%)

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
              +  ++ Q+WY G++ R  AE +L+   E ++LVRNS++   DF LS+K  +  +H  
Sbjct: 3   VLRSSSMQQQIWYFGSLERIVAEQILQPTSEGTFLVRNSKSILGDFVLSVKQKEEVIHYI 62

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
           + R       L   +  F S+  ++ HY + 
Sbjct: 63  IRREHSK---LVLKNHVFLSMVTLLEHYKTH 90


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score = 95.0 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 37/193 (19%), Positives = 69/193 (35%), Gaps = 11/193 (5%)

Query: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
           +            S P   + E SL   +  F G     +    E +            +
Sbjct: 422 NVPQQRKSSLPPFSAPVRSVSENSL--VAMDFSGRTGRIIDNPVEAQSAALEEGQTWRKR 479

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL--RLCKEASYLVRNSETS 353
           S +   +   SP+   +  A     QVW+HG I R +A  ++  +   +  +L+R+S+++
Sbjct: 480 SQRMNVLGSPSPMHPSSLSAAIHRTQVWFHGRIVREEAHKMIIQQGQVDGLFLLRDSQSN 539

Query: 354 KNDFSLSLKSSQGFMHMKL---SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
              F L+L   Q   H ++       +  + L   S  F+ +  +V  Y   +    G  
Sbjct: 540 PRAFVLTLCHHQKIKHFQILPCEEDGQVFFSLDDGSTKFTDLIHLVDFYQLNR----GVL 595

Query: 411 HMSLLYPVAIRTL 423
              L +P     L
Sbjct: 596 PCKLKHPCTAVAL 608


>UniRef50_B3XVX7 Protein tyrosine kinase HTK16 n=1 Tax=Codonosiga gracilis
           RepID=B3XVX7_9EUKA
          Length = 703

 Score = 95.0 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 22/105 (20%), Positives = 48/105 (45%), Gaps = 9/105 (8%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           +Q+++HG++ R +AE  ++      +L+R S +    + LS+      +H K+ + +   
Sbjct: 2   DQLFFHGSVPRAEAEAKVQRGGNGVFLIRQSSSDSGSYVLSVGYQGEALHFKI-KNEGEC 60

Query: 380 YVLGQNSPPFSSVPEIVHHYASRK--LPIKGAEHMSLLYPVAIRT 422
           +      P F  + ++  H+      LP       +L  PV +R+
Sbjct: 61  WFSIDEGPVFEGLADLTEHFVHFPDGLP------CNLTSPVLVRS 99



 Score = 88.4 bits (217), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 31/119 (26%), Positives = 55/119 (46%), Gaps = 9/119 (7%)

Query: 287 PRLSA---GNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR--LCK 341
           PR  A   GN ++ + LS                LE   +YHG ++R  AEN++      
Sbjct: 212 PRQVASRVGNTQTCRVLSDSEEGYGVPEIKKLFELE---YYHGKLNRVAAENIITIYGSN 268

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           +  +LVR S+ S  +F LS+  +Q   H ++  ++        + P F+S+ +++ HY 
Sbjct: 269 DGLFLVRFSKGS-GNFILSMCFNQSCFHFQIQCSQAENCYFIDDGPGFTSLGDLIQHYR 326


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score = 95.0 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 41/204 (20%), Positives = 79/204 (38%), Gaps = 15/204 (7%)

Query: 224 KDLPWPPPVGQLDSSPSLPDGDRDISGP--ASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
             L       Q ++    P   + +     +    E     +   F   E   L+  R E
Sbjct: 48  PWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAE 107

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP-LENQVWYHGAISRTDAENLLRL- 339
           +  +  + +    K+   L  E   P    T+  +  LE   WYH  I+R  AE+LLR  
Sbjct: 108 EYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQE 167

Query: 340 CKEASYLVRNSETSKNDFSLSL-----KSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
            KE +++VR+S      +++S+      +     H ++ +    ++ + +    F S+PE
Sbjct: 168 SKEGAFIVRDSR-HLGSYTISVFMGARSTEAAIKHYQIKKNDSGQWYVAERH-AFQSIPE 225

Query: 395 IVHHYASRKLPIKGAEHMSLLYPV 418
           ++ ++      +       L YPV
Sbjct: 226 LIWYHQHNAAGLMTR----LRYPV 245


>UniRef50_UPI000180B456 PREDICTED: similar to SH2 domain-containing protein 4B n=1
           Tax=Ciona intestinalis RepID=UPI000180B456
          Length = 537

 Score = 95.0 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 49/259 (18%), Positives = 94/259 (36%), Gaps = 23/259 (8%)

Query: 167 PYEPEEDGATAEGEGAPWPRES----RLPEDDERPPEEYDQP-WEWKKERISKAF----- 216
           P  P+  G  +  +      ES      P+ D    EE++Q    +K+E   +       
Sbjct: 260 PKSPK--GQRSVEKETENIYESVDDVTKPQVDLVSNEEWNQQLRRFKEEDEKRKIRARRA 317

Query: 217 AVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASP-LPEPSLEDSSAQFEGPEKSCL 275
           ++++K    +       ++ S                  L +P+L    A  +       
Sbjct: 318 SIEVKRQSLIAVNRNKSKIKSLRQKFAKLGSFDNEKESKLEKPTLPPKLAVIDTVVPPIT 377

Query: 276 SPGREEKGRLPPRLSAGNPKSAKPLSM-----EPSSPLGEWTDPALPLENQVWYHGAISR 330
           S             + G P S   +       + S+ + +  D  +P     W+HG ISR
Sbjct: 378 SLRARSPVVTSRLSTTGKPNSRNDVKRWFEDKQTSAFVDDRGDVIIP----TWFHGIISR 433

Query: 331 TDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFS 390
           +DAE+LL    E  +L+R S+     ++LS K+     H  +  ++   +  G +     
Sbjct: 434 SDAESLLCSRPERDFLIRLSDKIWG-YALSYKAEDRVKHFLIDASEGSYHFFGNDQIRHE 492

Query: 391 SVPEIVHHYASRKLPIKGA 409
           S+ E+V ++    +   G 
Sbjct: 493 SLAELVEYHKEEDITYNGE 511


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score = 94.6 bits (233), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 18/81 (22%), Positives = 41/81 (50%), Gaps = 2/81 (2%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           ++WYHG I+R   E +L    + ++LVR+S     D++L +  +    H ++ +   +  
Sbjct: 44  KLWYHGNITREHTEKILSGQADGTFLVRDSTNFPGDYTLCMAFNGKVEHYRIYQL--NGI 101

Query: 381 VLGQNSPPFSSVPEIVHHYAS 401
           +   +   F ++ +++ HY  
Sbjct: 102 LTCDHEETFDNLTQLIAHYKR 122


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score = 94.6 bits (233), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 2/90 (2%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
            + ++   W+    SR+ AE LLR      +++R  ++S  +FS+S++      H K+ R
Sbjct: 50  YIEIQTPRWFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFKVMR 109

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
               +Y L   S  F+S+ ++V  Y +  +
Sbjct: 110 DSRGQYFLW--SEKFTSLNKLVDFYRTSSI 137


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score = 94.6 bits (233), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 49/246 (19%), Positives = 90/246 (36%), Gaps = 14/246 (5%)

Query: 162 PLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
           P+  TP      G    G   P P ++  P     PP     P+  +        A    
Sbjct: 160 PIGSTPSAGPGGGRVPRGPLPPTPVQNLAPS----PPPHGGTPY-VQNSHGPSPNAPRGY 214

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLED----SSAQFEGPEKSCLSP 277
              +L  P P     S     D            PEP   D    +   + G E+  L  
Sbjct: 215 ESHELAAPAPSSGRSSYHGQTDQPPPPVPSRVRPPEPKPSDFDVIAMYDYPGLERGDLPL 274

Query: 278 GREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL 337
            + ++  +         ++      E   P        + L+++ W+   +SRT AEN+L
Sbjct: 275 VKGQRVTVFDATREFWWRARDEQGSEGYIPSNYVK--KMGLDSEEWFFPQLSRTRAENIL 332

Query: 338 RL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
           +   +E  ++VRNS + +N ++LS+       H  +   + +KY + +    F S+ E++
Sbjct: 333 KGEGREGGFVVRNS-SRENMYTLSICHEGQVRHYHIKLDESNKYFISEKH-RFPSIKELI 390

Query: 397 HHYASR 402
            ++   
Sbjct: 391 EYHKLN 396


>UniRef50_P05433 P47(GAG-CRK) protein n=1 Tax=Avian sarcoma virus CT10
           RepID=GAGC_AVISC
          Length = 440

 Score = 94.6 bits (233), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 48/255 (18%), Positives = 81/255 (31%), Gaps = 29/255 (11%)

Query: 188 SRLPEDDERPPEEYDQPW-EWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDR 246
              PE  E+P  E      E   E   +  A         P            ++     
Sbjct: 109 PPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYYCGAAIGCNCA 168

Query: 247 DISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSS 306
             S P  P     L  S A     +       R  +     R +            +   
Sbjct: 169 TASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPRGAEQPRAGRGAGHRGLRRPAGRGQRVR 228

Query: 307 PLGEWTDPALPLENQV---WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKS 363
           P G     A   +++    WY G +SR DA +LL+  +  ++LVR+S +   DF LS+  
Sbjct: 229 PAGGAALMAGQFDSEDRGSWYWGRLSRGDAVSLLQGQRHGTFLVRDSGSIPGDFVLSVSE 288

Query: 364 SQGFMHMKLS------------------RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP 405
           S    H  ++                       ++++G     F S+P ++  Y    L 
Sbjct: 289 SSRVSHYIVNSLGPAGGRRAGGEGPGAPGLNPTRFLIGD--QVFDSLPSLLEFYKIHYL- 345

Query: 406 IKGAEHMSLLYPVAI 420
               +  +L+ PV+ 
Sbjct: 346 ----DTTTLIEPVSR 356


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score = 94.2 bits (232), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 30/90 (33%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           A  L    WYHG I+R   E++L   K   +LVR+S T K  + LS+  +    H  ++ 
Sbjct: 2   ADRLFMYSWYHGDITRPACESILMAQKPGLFLVRDSSTCKGGYVLSVSENNKVSHYIIT- 60

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
            K  +Y +G     F+ +PEIV  Y    L
Sbjct: 61  NKNSQYQIGD--QTFNDLPEIVEFYKRHFL 88


>UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME
          Length = 409

 Score = 94.2 bits (232), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 45/228 (19%), Positives = 81/228 (35%), Gaps = 26/228 (11%)

Query: 211 RISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGP 270
            I KAFA+    +  L  P     ++ S      +     P    PE          +  
Sbjct: 169 TIGKAFALRFNALSRLNDPSADCNINQSCKENVKEYYNDLPNKLPPEVPEPQQQQVQQPL 228

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT------------------ 312
                   +    +   RLS+       P   + ++ LG +                   
Sbjct: 229 HPHAPRVAQLNLKKPRDRLSSNLIDLNSPPPDQTTNKLGHFDPLQATTAANSVLPSVRDV 288

Query: 313 --DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
              P  PL  +VW+H  ISR  +E LL+  ++  +LVR S+  +  + L+    +   H+
Sbjct: 289 FDGPQCPLTAEVWFHAGISRPISERLLQ--QDGDFLVRESQGKRGQYVLTGLEGKTPKHL 346

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH-MSLLYP 417
            L    E   V+      F S+  +++++ +  LPI   +  + L  P
Sbjct: 347 LLI-DPEG--VVRTKDRIFDSISHLINYHWAHALPIISEDSELVLRNP 391


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score = 94.2 bits (232), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 35/137 (25%), Positives = 60/137 (43%), Gaps = 36/137 (26%)

Query: 317 PLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           P E +VWYHG I++ +A NLL    +  S+LVR S+ +  D+SL  +++      K+S T
Sbjct: 353 PHEGKVWYHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRTNDIIQRFKISPT 412

Query: 376 KEHKYVLGQNS-------------------------PPF------SSVPEIVHHYASRKL 404
             ++Y++G                              F       SV +I+ HY   ++
Sbjct: 413 SNNQYMMGGRYYNRYEPICMLGHHFQSSGYHVFSFFLRFNCAASVDSVDDIIDHYKKEQI 472

Query: 405 PIKGAEHMSLLYPVAIR 421
                E  +L  PV+++
Sbjct: 473 ----VEGYNLKEPVSVQ 485



 Score = 93.8 bits (231), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 56/255 (21%), Positives = 87/255 (34%), Gaps = 25/255 (9%)

Query: 180 EGAPWPRESRLPEDDERPPEEYDQ-----PWEWKKERISKAFAVDIKVIKDLPWPPPVGQ 234
              P P  +R PE  + P     Q     P       I+   +        +      G 
Sbjct: 33  PYYPRPGRARFPEMGQGPTPAVRQHSNTSPDSLPDMSITYPLSGGDISGAAVSSTGSGGA 92

Query: 235 LDSSP--SLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP----- 287
           +                   SP  E      S    GP+   + P        PP     
Sbjct: 93  VGGHTLFQGTSSGTGSGTCCSPTSEGPASRISPTSTGPDGPTVFPPLPPPPPPPPGTVDE 152

Query: 288 -RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE-ASY 345
             +  G     + ++   S+P    + P +P     WYHG + RT AE  LR  +   SY
Sbjct: 153 SDMQDGTECDEEEVAFPLSAPPSNHSPPRMP----RWYHGKLDRTIAEERLRQARNPGSY 208

Query: 346 LVRNSETSKNDFSLSLKSSQGFM-HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           L+R S+     F LS  S    + H ++       Y+       FSS+ +++ +Y+    
Sbjct: 209 LIRESDRRPGSFVLSFLSMTNVVNHFRIIAMCGDYYI---GGRRFSSLSDLIGYYSYVSC 265

Query: 405 PIKGAEHMSLLYPVA 419
            +KG +   LL PVA
Sbjct: 266 LLKGEK---LLSPVA 277


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score = 94.2 bits (232), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 28/106 (26%), Positives = 54/106 (50%), Gaps = 4/106 (3%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS-KNDFSLSLKSSQGFMHMKLSRT 375
            L++  WY G ISR +    LR   + ++LVR++ +  + +++L+L+       +K+   
Sbjct: 324 SLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH- 382

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
           ++  Y   +    F SV ++++HY    L    A+    LLYPV+ 
Sbjct: 383 RDGHYGFSEP-LTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427



 Score = 91.5 bits (225), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 3/113 (2%)

Query: 307 PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
            L E  D     E + WY G I+RT AE +L   ++ ++L+R S + +  ++ S+     
Sbjct: 606 ALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVVDGD 664

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
             H  + RT    +   +    + S+ E+V HY    L     A  ++L +PV
Sbjct: 665 TKHCVIYRTATG-FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPV 716


>UniRef50_UPI0001925126 PREDICTED: protein tyrosine kinase 18 n=2 Tax=Eumetazoa
           RepID=UPI0001925126
          Length = 914

 Score = 94.2 bits (232), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 19/100 (19%), Positives = 47/100 (47%), Gaps = 6/100 (6%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           +E  +WYH  ++R +A+ +++   + ++LVRN+ +    ++LS        H  +    +
Sbjct: 542 VEKLLWYHADMTRQEADQVMQNTNDGTFLVRNA-SKPKMYTLSFSFQGVVKHYHIKTDSD 600

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           + + + Q    F SV +++ ++      +       L +P
Sbjct: 601 NLFYVSQRHS-FESVVQLIEYHKLNSAGLATR----LRFP 635


>UniRef50_A6NKC9 SH2 domain-containing protein 7 n=4 Tax=Euteleostomi
           RepID=SH2D7_HUMAN
          Length = 451

 Score = 94.2 bits (232), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 25/83 (30%), Positives = 46/83 (55%), Gaps = 1/83 (1%)

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
            W+HG I+R   E LLR     S+L+R S+ +   + LS + S    H  +++ +  +Y+
Sbjct: 50  PWFHGFITRKQTEQLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYI 108

Query: 382 LGQNSPPFSSVPEIVHHYASRKL 404
           +  ++   S++ E+VHHY   +L
Sbjct: 109 ISGDTQSHSTLAELVHHYQEAQL 131


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score = 93.8 bits (231), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 44/229 (19%), Positives = 74/229 (32%), Gaps = 20/229 (8%)

Query: 205 WEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSS 264
           WE  K+    +       I    W     +            + +   SP         +
Sbjct: 507 WELSKKSWKFSDEGCPSPIISPEWNLGSYRQRMLMQESQAKEEWAR--SPQGPGGKNRVA 564

Query: 265 AQFEGPEKSCLSPGRE-------EKGRLPPRLSAGNPKSAKPLSMEP--SSPLGEWTDPA 315
             F G     ++   E       E      R S+G+          P  S     +  P 
Sbjct: 565 MDFTGYRGRVIANPNEAVAVAVEEGQSWRKRHSSGSRALVGSPRNSPLLSPRSSRFISPQ 624

Query: 316 LPLENQVWYHGAISRTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
              + Q W+H  I+R +A N++ +    +  YLVR S+T    F L+    Q   H ++ 
Sbjct: 625 GVHQTQPWFHHGINREEANNMMHMQGMVDGLYLVRESQTFPGTFVLTFCHDQRVKHYQIQ 684

Query: 374 RT---KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
                 +  Y L +    F  + ++V  Y   +    GA   SL +P  
Sbjct: 685 PNVIDDKTFYSLDEGETKFGDLVQLVEFYQINR----GALPHSLTHPCT 729


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score = 93.8 bits (231), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 8/108 (7%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND---FSLSLKSSQGFMHMKLSR 374
           LE   WYHG + R D   LL   K+  +LVR +E  K +     LS+K +   MH  +  
Sbjct: 8   LEFAEWYHGLLPRKDINILLS--KQGQFLVRETEIKKGEGLQLVLSVKWNDKTMHFIIRH 65

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
                ++       F+S+  ++ ++   K PI       LL+ V  ++
Sbjct: 66  VDGKVFI---EKRQFNSIHALIRYHLVSKDPITDQSGAMLLHAVPRQS 110


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score = 93.8 bits (231), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 29/117 (24%), Positives = 55/117 (47%), Gaps = 9/117 (7%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQG 366
           L E        E++ WYH +++R  AE++L     + ++LVR      N +++S ++   
Sbjct: 653 LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRK-RNEPNSYAISFRAEGK 711

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
             H ++ +  E + V+  NS  F S+ +++ +Y    L       M L YP+    L
Sbjct: 712 IKHCRVQQ--EGQTVMLGNSE-FDSLVDLISYYEKHPL----YRKMKLRYPINEEAL 761



 Score = 89.6 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 34/125 (27%), Positives = 58/125 (46%), Gaps = 19/125 (15%)

Query: 310 EWTDPALPLE-NQVWYHGAIS-----RTDAENLLR------LCKEASYLVRNSETSKNDF 357
           +    +  L  N+ W+HG +      R  AE LL          + S+LVR SET   D+
Sbjct: 536 KEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDY 595

Query: 358 SLSLKSSQGFMHMKLSRTKEH---KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMS 413
           +LS   +    H ++   ++    K+ L  N   F S+ +++ HY  +++P++  E  M 
Sbjct: 596 TLSFWRNGKVQHCRIHSRQDAGTPKFFLTDN-LVFDSLYDLITHY--QQVPLRCNEFEMR 652

Query: 414 LLYPV 418
           L  PV
Sbjct: 653 LSEPV 657


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...   417   e-115
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...   226   2e-57
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...   221   4e-56
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...   202   2e-50
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...   197   5e-49
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...   195   2e-48
UniRef50_O14544 Suppressor of cytokine signaling 6 n=31 Tax=Eute...   191   4e-47
UniRef50_Q4S861 Chromosome 5 SCAF14709, whole genome shotgun seq...   184   5e-45
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...   181   3e-44
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   169   1e-40
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   166   2e-39
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          162   2e-38
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   161   4e-38
UniRef50_UPI00006A214E SH2 domain-containing adapter protein E. ...   160   6e-38
UniRef50_C3ZPI6 Putative uncharacterized protein n=2 Tax=Branchi...   160   1e-37
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          159   2e-37
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   159   2e-37
UniRef50_A4II17 Shd protein (Fragment) n=3 Tax=Xenopus (Silurana...   157   5e-37
UniRef50_Q4RIA8 Chromosome 8 SCAF15044, whole genome shotgun seq...   157   6e-37
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   157   6e-37
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   156   1e-36
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   155   3e-36
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...   155   4e-36
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...   154   6e-36
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   154   8e-36
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   153   1e-35
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   152   2e-35
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   152   2e-35
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...   152   2e-35
UniRef50_UPI00017930CA PREDICTED: similar to SH2 domain containi...   151   4e-35
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   151   4e-35
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   151   6e-35
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   150   7e-35
UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=...   150   9e-35
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   149   2e-34
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   148   3e-34
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...   148   4e-34
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   147   5e-34
UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=...   144   5e-33
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   144   6e-33
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   143   9e-33
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   142   2e-32
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   142   3e-32
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   140   7e-32
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   140   1e-31
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   140   1e-31
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   138   2e-31
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   138   2e-31
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   138   3e-31
UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA ...   138   3e-31
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...   138   4e-31
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...   137   1e-30
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   137   1e-30
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   136   1e-30
UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Su...   135   2e-30
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   135   2e-30
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...   135   3e-30
UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU...   135   3e-30
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   134   7e-30
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   134   7e-30
UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI         133   8e-30
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...   133   9e-30
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...   133   1e-29
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...   133   1e-29
UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 doma...   133   1e-29
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   132   2e-29
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...   132   2e-29
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   132   3e-29
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...   132   3e-29
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   131   4e-29
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   131   5e-29
UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS         130   7e-29
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...   130   1e-28
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   130   1e-28
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   129   1e-28
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...   129   2e-28
UniRef50_Q6GP30 MGC80721 protein n=2 Tax=Xenopus RepID=Q6GP30_XENLA   129   2e-28
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   129   2e-28
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   128   3e-28
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...   128   3e-28
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   128   4e-28
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   128   4e-28
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   128   4e-28
UniRef50_UPI000069FBD6 Tensin-like C1 domain-containing phosphat...   128   5e-28
UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis...   128   5e-28
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   127   9e-28
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...   127   9e-28
UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=...   127   1e-27
UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 doma...   126   1e-27
UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=...   126   1e-27
UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni ...   126   1e-27
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     126   2e-27
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   126   2e-27
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   126   2e-27
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   125   2e-27
UniRef50_Q63HR2 Tensin-like C1 domain-containing phosphatase n=2...   125   2e-27
UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine ki...   125   3e-27
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   125   3e-27
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   125   4e-27
UniRef50_UPI0000F2151D PREDICTED: similar to SH2B adapter protei...   124   5e-27
UniRef50_D0IN15 Suppressor of cytokine signaling 6 n=4 Tax=Eutel...   124   6e-27
UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3...   124   6e-27
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...   124   7e-27
UniRef50_UPI0001925BB9 PREDICTED: similar to Shb=Src homology 2 ...   124   7e-27
UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni Re...   123   8e-27
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   123   8e-27
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   123   9e-27
UniRef50_D2H965 Putative uncharacterized protein (Fragment) n=3 ...   123   1e-26
UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata R...   123   1e-26
UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 ...   123   1e-26
UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepI...   123   1e-26
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   123   1e-26
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   123   1e-26
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   123   2e-26
UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun se...   123   2e-26
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...   122   2e-26
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS         122   2e-26
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   122   3e-26
UniRef50_Q5BWZ4 SJCHGC04657 protein (Fragment) n=1 Tax=Schistoso...   122   3e-26
UniRef50_UPI000186F2CC Phosphatidylinositol 3-kinase regulatory ...   121   4e-26
UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni Re...   120   7e-26
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...   120   8e-26
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   120   1e-25
UniRef50_UPI000180B9A8 PREDICTED: similar to Protein vav-2 n=1 T...   120   1e-25
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   120   1e-25
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...   119   2e-25
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...   119   2e-25
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...   119   2e-25
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   119   2e-25
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   118   3e-25
UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containi...   118   3e-25
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...   118   3e-25
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   118   3e-25
UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosi...   118   3e-25
UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n...   118   3e-25
UniRef50_UPI000051A4E9 PREDICTED: similar to lymphocyte cytosoli...   118   3e-25
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...   118   3e-25
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   118   4e-25
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   118   4e-25
UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis...   118   5e-25
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   118   5e-25
UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis R...   118   5e-25
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   117   6e-25
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   117   6e-25
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...   117   8e-25
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   117   8e-25
UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis R...   117   9e-25
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME        117   1e-24
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...   117   1e-24
UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosi...   116   1e-24
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   116   2e-24
UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=...   116   2e-24
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...   116   2e-24
UniRef50_B8JL24 Novel protein similar to human and mouse SH2 dom...   116   2e-24
UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Eutele...   115   2e-24
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   115   2e-24
UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Tak...   115   3e-24
UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=...   115   3e-24
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   115   4e-24
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...   115   4e-24
UniRef50_B2MW85 Phosphatidylinositol 3-kinase 60 n=1 Tax=Bombyx ...   115   4e-24
UniRef50_UPI000186E4D4 hypothetical protein Phum_PHUM500510 n=1 ...   115   5e-24
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   114   5e-24
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...   114   5e-24
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...   114   5e-24
UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicu...   114   5e-24
UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis R...   114   6e-24
UniRef50_UPI000052380F PREDICTED: similar to phosphoinositide-3-...   114   6e-24
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...   114   6e-24
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...   114   6e-24
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...   114   6e-24
UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Tak...   114   6e-24
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   114   6e-24
UniRef50_UPI000186E9A4 SH2 domain-containing protein 4A, putativ...   114   7e-24
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   114   8e-24
UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniot...   114   8e-24
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...   113   8e-24
UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene ...   113   8e-24
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   113   9e-24
UniRef50_UPI000069EA62 SH2 domain-containing protein 4A (Protein...   113   1e-23
UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchi...   113   1e-23
UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona...   113   1e-23
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...   113   1e-23
UniRef50_UPI0000E45D4F PREDICTED: similar to SH2 domain containi...   113   1e-23
UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_...   113   1e-23
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   113   1e-23
UniRef50_P05433 P47(GAG-CRK) protein n=1 Tax=Avian sarcoma virus...   113   2e-23
UniRef50_UPI000179134F PREDICTED: similar to signal transduction...   112   2e-23
UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n...   112   2e-23
UniRef50_Q7Z7G1-3 Isoform 3 of Cytokine-dependent hematopoietic ...   112   2e-23
UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos...   112   2e-23
UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE      112   2e-23
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   112   2e-23
UniRef50_B8A4I5 Novel protein similar to vertebrate lymphocyte c...   112   2e-23
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...   112   3e-23
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   112   3e-23
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE        112   3e-23
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...   112   3e-23
UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio Rep...   112   3e-23
UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   112   3e-23
UniRef50_Q9D7V1 SH2 domain-containing protein 4A n=10 Tax=Tetrap...   112   3e-23
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   112   4e-23
UniRef50_B7PK27 Putative uncharacterized protein n=1 Tax=Ixodes ...   111   4e-23
UniRef50_Q4H2S5 Suppressor of cytokine signaling n=1 Tax=Ciona i...   111   4e-23
UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gam...   111   4e-23
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...   111   4e-23
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   111   5e-23
UniRef50_UPI000180B456 PREDICTED: similar to SH2 domain-containi...   111   5e-23
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...   111   5e-23
UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n...   111   5e-23
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   111   5e-23
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME       111   6e-23
UniRef50_A9UNJ0 Predicted protein n=1 Tax=Monosiga brevicollis R...   111   6e-23
UniRef50_B0XFC9 Phosphatidylinositol 3-kinase regulatory subunit...   111   6e-23
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...   111   6e-23
UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID...   111   7e-23
UniRef50_UPI0000E818A6 PREDICTED: similar to Myosin-VIIa n=3 Tax...   110   7e-23
UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pe...   110   8e-23
UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain pr...   110   8e-23
UniRef50_UPI0000D56E93 PREDICTED: similar to predicted protein n...   110   8e-23
UniRef50_A9VDX4 Predicted protein n=1 Tax=Monosiga brevicollis R...   110   1e-22
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   110   1e-22
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...   110   1e-22
UniRef50_UPI000180BA50 PREDICTED: similar to growth factor recep...   110   1e-22
UniRef50_UPI0001924162 PREDICTED: similar to SH2-B PH domain con...   110   1e-22
UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tet...   110   1e-22
UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A...   110   1e-22
UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota Re...   110   1e-22
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   110   2e-22
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   110   2e-22
UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=...   109   2e-22
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...   109   2e-22
UniRef50_A8P112 Variant SH3 domain containing protein n=1 Tax=Br...   109   2e-22
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...   109   2e-22
UniRef50_C3YYE3 Putative uncharacterized protein n=1 Tax=Branchi...   109   2e-22
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...   109   2e-22
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...   109   2e-22
UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax...   109   2e-22
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...   109   2e-22
UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n...   109   2e-22
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   109   2e-22
UniRef50_A8NSH4 SH2 domain containing protein n=1 Tax=Brugia mal...   108   3e-22
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...   108   3e-22
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...   108   3e-22
UniRef50_UPI00016E6E61 UPI00016E6E61 related cluster n=3 Tax=Tak...   108   3e-22
UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona inte...   108   3e-22
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    108   3e-22
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS         108   3e-22

Sequences not found previously or not previously below threshold:

UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni ...   113   9e-24
UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepI...   113   1e-23

>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score =  417 bits (1072), Expect = e-115,   Method: Composition-based stats.
 Identities = 419/423 (99%), Positives = 421/423 (99%)

Query: 1   MQQEGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 60
           MQQEGGPVRSAPCRTGTLEGSRQGSPGH+KRASPKGSLSSAQPHSWMLTPSPLNSHCAHR
Sbjct: 58  MQQEGGPVRSAPCRTGTLEGSRQGSPGHKKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 117

Query: 61  EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 120
           EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG
Sbjct: 118 EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEG 177

Query: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGE 180
           SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT EGE
Sbjct: 178 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATPEGE 237

Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
           GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS
Sbjct: 238 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 297

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL
Sbjct: 298 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 357

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
           SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS
Sbjct: 358 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 417

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           LKSSQGFMHMKLSRTK +KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI
Sbjct: 418 LKSSQGFMHMKLSRTKNNKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 477

Query: 421 RTL 423
           RTL
Sbjct: 478 RTL 480


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score =  226 bits (574), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 244/396 (61%), Positives = 258/396 (65%), Gaps = 65/396 (16%)

Query: 28  HRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTR 87
                 P  S + + P     TP P +           SP       +          + 
Sbjct: 116 DPYSGGPSASAALSTPAVPGPTPPPRHG----------SPPHRLIRVETPGPPAPPPDSG 165

Query: 88  LRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMM 147
                 R       LAILEDYADPFDVQETGEGS G SGAP KVPENDGYMEPYEAQKMM
Sbjct: 166 PPASSDR-------LAILEDYADPFDVQETGEGSGGTSGAPGKVPENDGYMEPYEAQKMM 218

Query: 148 AEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEW 207
           AEIRGSKETA QPLPLYDTPYEPE++GA+ EGEG PWPRESRLPEDDERPPEEYDQPWEW
Sbjct: 219 AEIRGSKETAAQPLPLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEW 278

Query: 208 KKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQF 267
           KKERISKAFA   +  ++   P    +    P L  G+   + P                
Sbjct: 279 KKERISKAFAAQFEGSENCLSPGREEKGRLPPRLSAGNPKSAKP---------------- 322

Query: 268 EGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGA 327
                                           L MEPSSPLGEWTDPALPLENQVWYHGA
Sbjct: 323 --------------------------------LGMEPSSPLGEWTDPALPLENQVWYHGA 350

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
           ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP
Sbjct: 351 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 410

Query: 388 PFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           PFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
Sbjct: 411 PFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 446


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score =  221 bits (563), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 195/410 (47%), Positives = 229/410 (55%), Gaps = 76/410 (18%)

Query: 22  RQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSP----QPVANGPKQK 77
           +  SP HR      G   S  P       S  +   A   P   SP     P      Q 
Sbjct: 117 KYVSPKHRLIKVDTGEKGSCSPTGGNTAGSSGSPGQAFTSPSVPSPGVRSPPATAVAPQL 176

Query: 78  KKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGY 137
           ++S                     +AI+EDYADPFD +       G+  APEKV ENDGY
Sbjct: 177 EESKQD-----------------KVAIVEDYADPFDAK----QVPGSQNAPEKVTENDGY 215

Query: 138 MEPYEAQKMMAEIRGS--KETATQPLPLYDTPYEPEEDGATAEGEGAP--WPRESRLPED 193
           MEPYEAQKMMAEIR    KE    PL LYDTPYEP E+G  +EGE +    PRESRLP+D
Sbjct: 216 MEPYEAQKMMAEIRRRGSKELPCTPLHLYDTPYEPSENGLDSEGEKSTSQRPRESRLPQD 275

Query: 194 DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
           DER                                                  +   P  
Sbjct: 276 DER-----------------------------------------------PPEEYDQPWE 288

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
              E   +  +AQF+  +K+ ++  +E+K R   R SAGN K+ K  S+E    +GE  D
Sbjct: 289 WKKERISKAFAAQFDSADKTGMAAAKEDKPRHMHRHSAGNLKAIKHPSVEHCISVGERID 348

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           P+LPLE+Q WYHGAISR DAE+LLRLCKEASYLVRNSET+K DFSLSLKS QGFMHMKLS
Sbjct: 349 PSLPLESQFWYHGAISRADAESLLRLCKEASYLVRNSETNKIDFSLSLKSIQGFMHMKLS 408

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           RTKE+KYVLG NSPPF+SVPEI+HHYAS+KLPIKGAEHMSLLYPVA+RTL
Sbjct: 409 RTKENKYVLGHNSPPFNSVPEIIHHYASQKLPIKGAEHMSLLYPVAVRTL 458


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score =  202 bits (514), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 155/327 (47%), Positives = 189/327 (57%), Gaps = 60/327 (18%)

Query: 101 PLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQP 160
            + I +DY+DPFD +   +  AG         E+ GYMEPYEAQ++M E +  +   +Q 
Sbjct: 239 KVTIADDYSDPFDAKNDLKSKAGK-------GESAGYMEPYEAQRIMTEFQRQESVRSQH 291

Query: 161 --LPLYDTPYEPEEDGATAEGEGAPWP--RESRLPEDDERPPEEYDQPWEWKKERISKAF 216
             + LYDTPYEPE     ++ E    P  RES+LP+DD+RP +EYDQPWEW +  I    
Sbjct: 292 KGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALA 351

Query: 217 AVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLS 276
           A      K    P P                                             
Sbjct: 352 AQFNGNEKRQSSPSP--------------------------------------------- 366

Query: 277 PGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL 336
                  R   R   G  K  K  S E    LGE  DPA+PLE Q+WYHGAISR DAENL
Sbjct: 367 ---SRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENL 423

Query: 337 LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
           LRLCKE SYLVRNS+TSK+D+SLSL+S+QGFMHMKL++TKE KYVLGQNSPPF SVPE++
Sbjct: 424 LRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSVPEVI 482

Query: 397 HHYASRKLPIKGAEHMSLLYPVAIRTL 423
           H+Y +RKLPIKGAEH+SLLYPVA+RTL
Sbjct: 483 HYYTTRKLPIKGAEHLSLLYPVAVRTL 509


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score =  197 bits (501), Expect = 5e-49,   Method: Composition-based stats.
 Identities = 207/286 (72%), Positives = 216/286 (75%), Gaps = 48/286 (16%)

Query: 138 MEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERP 197
           MEPYEAQKMMAEIRGSKETA QPLPLYDTPYEPE++GA+ EGEG PWPRESRL      P
Sbjct: 1   MEPYEAQKMMAEIRGSKETAAQPLPLYDTPYEPEDEGASPEGEGTPWPRESRL------P 54

Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
            ++   P E+                                           P     E
Sbjct: 55  EDDERPPEEY-----------------------------------------DQPWEWKKE 73

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
              +  +AQFEG E +CLSPGREEKGRLPPRLSAGNPKSAKPL MEPSSPLGEWTDPALP
Sbjct: 74  RISKAFAAQFEGSE-NCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALP 132

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE
Sbjct: 133 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 192

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL
Sbjct: 193 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 238


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score =  195 bits (495), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 128/323 (39%), Positives = 175/323 (54%), Gaps = 28/323 (8%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGS--KETATQ 159
           + ILEDYADP+D + T           E+V ENDGYMEPY+AQ+M+ EIR    K+   +
Sbjct: 198 VIILEDYADPYDAKRTKGQRDA-----ERVGENDGYMEPYDAQQMITEIRRRGSKDPLVK 252

Query: 160 PLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVD 219
            L L D+P EP + G  +E             +   +PP+ YD P+E          A  
Sbjct: 253 ALQLLDSPCEPADGGLKSETLAKRR----SSKDLLGKPPQLYDTPYE---------PAEG 299

Query: 220 IKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGR 279
               +    PP     ++         +   P     E  +   S QFEG E+      R
Sbjct: 300 GPRAEGKARPPDSRLPENDER---PAAEYEQPWEWKKEQIVRALSVQFEGAERPSF---R 353

Query: 280 EEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL 339
           EE  R   R  +   K  KP   + S   GE  DP LPLE Q WYHGAISR +AE+ L+ 
Sbjct: 354 EETVRQHHRQKSWTQKILKPALSDHSE--GEKVDPGLPLEKQPWYHGAISRAEAESRLQP 411

Query: 340 CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           CKEA YLVRNSE+  + +S++LK+SQG +H+ +++TK++KY L Q S  F S+PE+VH+Y
Sbjct: 412 CKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYY 471

Query: 400 ASRKLPIKGAEHMSLLYPVAIRT 422
           ++ KLP KGAEHM+LLYPV  + 
Sbjct: 472 SNEKLPFKGAEHMTLLYPVHSKL 494


>UniRef50_O14544 Suppressor of cytokine signaling 6 n=31 Tax=Euteleostomi
           RepID=SOCS6_HUMAN
          Length = 535

 Score =  191 bits (485), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 78/450 (17%), Positives = 151/450 (33%), Gaps = 47/450 (10%)

Query: 2   QQEGGPVRS-APCRTGTLE---GSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHC 57
            ++GG  RS +    GTL+    ++Q S G  K  +P GS +     S    P       
Sbjct: 60  DEKGGKNRSKSESLMGTLKRRLSAKQKSKG--KAGTPSGSSADEDTFSSSSAPIVFKDVR 117

Query: 58  AHREPISS--------SPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLA--ILED 107
           A R PI S        SP P    P   +++  +    +R+  L     P P    + +D
Sbjct: 118 AQR-PIRSTSLRSHHYSPAPWPLRPTNSEETCIK--MEVRVKALVHSSSPSPALNGVRKD 174

Query: 108 YADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTP 167
           + D        E +     +     +   +++ +    +       ++     +PL    
Sbjct: 175 FHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGL---MPQDYIQYTVPL---- 227

Query: 168 YEPEEDGATAEGEGAPWPRESRLPEDDER-PPEEYDQPWEWKKERISKAFAVDIKVIKDL 226
               ++G         +  +S  P +    PP+   + +   + ++ +   V  ++  D 
Sbjct: 228 ----DEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQ 283

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
                +                  P      P ++++  Q      +       E  R  
Sbjct: 284 SVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCH 343

Query: 287 ----PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE 342
               P  + G  +    +       +   T+    L  Q WY G I+R +AE  L    +
Sbjct: 344 LNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPD 403

Query: 343 ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS-PPFSSVPEIVHH--- 398
            S+LVR+S   +   SLS +S    +H ++  +        Q      +S+ +++ H   
Sbjct: 404 GSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIR 463

Query: 399 --------YASRKLPIKGAEHMSLLYPVAI 420
                   Y+  +LP      + L  PV+ 
Sbjct: 464 DSENGAFCYSRSRLPGSATYPVRLTNPVSR 493


>UniRef50_Q4S861 Chromosome 5 SCAF14709, whole genome shotgun sequence n=2
           Tax=Tetraodon nigroviridis RepID=Q4S861_TETNG
          Length = 775

 Score =  184 bits (467), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 153/316 (48%), Positives = 192/316 (60%), Gaps = 53/316 (16%)

Query: 142 EAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEY 201
           +  +     RG KE + + LPLYDTPYEP E+G  ++ E +  PRESRLP+DDERPPEEY
Sbjct: 479 DEIRSGGTGRGPKEGSVRQLPLYDTPYEPAENGGDSDPERSRCPRESRLPQDDERPPEEY 538

Query: 202 DQPWEWKKERISKAFA---------------------------------VDIKVIKDLPW 228
           DQPWEWKKERISKAFA                                 V+IKVIK+LPW
Sbjct: 539 DQPWEWKKERISKAFAALLCYDCISYEGSVSDTGSGSHGGKDCTSNSLTVEIKVIKNLPW 598

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
           PPPVGQL+S+P++ +     +  A   P  +      QF+G EKS +SP ++ K R   R
Sbjct: 599 PPPVGQLNSTPTVVEELESPTQTAQAPPGQTF-----QFDGVEKSRMSPTKDGKTRPLQR 653

Query: 289 LSAGNPKSAKPLSMEPSSP-LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
            S+G   + K  S+E   P L E  DP++PLE+Q+             L +LC     ++
Sbjct: 654 HSSGCLVNTKMSSLEHCGPSLAERIDPSMPLESQL-------------LCQLCSNCRVVI 700

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           R +   +  F   L+SSQGFMHMKLSRTKE+KY+LGQNS PF SVPEI+H Y+S KLPIK
Sbjct: 701 RAAVKRR-VFPCVLRSSQGFMHMKLSRTKENKYILGQNSCPFDSVPEIIHFYSSCKLPIK 759

Query: 408 GAEHMSLLYPVAIRTL 423
           GAEHMSLLYPVAIRTL
Sbjct: 760 GAEHMSLLYPVAIRTL 775



 Score = 45.4 bits (105), Expect = 0.004,   Method: Composition-based stats.
 Identities = 29/56 (51%), Positives = 33/56 (58%), Gaps = 2/56 (3%)

Query: 93  LRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMA 148
                    L ILEDYADPFD ++ G G+       +   ENDGYMEPYEAQKMMA
Sbjct: 287 PPTPPSFLQLIILEDYADPFDAEQAGGGTQT--STEKVTTENDGYMEPYEAQKMMA 340


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score =  181 bits (459), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 133/352 (37%), Positives = 182/352 (51%), Gaps = 68/352 (19%)

Query: 83  RSTTRLRIIRLRDRLEPR----PLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYM 138
           RS   L  + L +  +P     P+    DY+DPFDV+      +      +  PEN+GYM
Sbjct: 97  RSKILLSSVSLEEPTDPVVPSAPVMGDTDYSDPFDVRLDPRPESAQG---QITPENNGYM 153

Query: 139 EPYEAQKMMAEIRGSKETATQ-----PLPLYDTPYEPEEDGATAEGEGAPWPRESRLPED 193
           EPYEAQK++ E++              + LYD PYE                        
Sbjct: 154 EPYEAQKVITELQRRAGGGAGGWGRGEVQLYDAPYE------------------------ 189

Query: 194 DERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
            ER P + D P E ++ R+ +                                +   P  
Sbjct: 190 -ERVPGQPDLPEEGRESRLPQDDDR-------------------------PADEYDQPWE 223

Query: 254 PLPEPSLEDSSAQFEGPE--KSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
              E   +  + QFEG E  +SC    R    R PP   +   +        P S +GE 
Sbjct: 224 WKKEHISKAFAVQFEGAEWDRSCSPTERLRCSRAPPTTGSMKLRKPSD----PHSMIGER 279

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
            DP+LPLE QVWYHG++SR++AE+LL LCKE SYLVRNSETS+ D+SLSL+S QGFMHMK
Sbjct: 280 VDPSLPLEKQVWYHGSLSRSEAESLLTLCKECSYLVRNSETSRLDYSLSLRSCQGFMHMK 339

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            S+ K+ +Y+LGQNSPPF ++PE++H+Y + KLPIKGAEH+SLL+PV ++TL
Sbjct: 340 FSQCKDGRYILGQNSPPFETIPEVIHYYTTHKLPIKGAEHLSLLFPVLVQTL 391


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  169 bits (428), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 52/223 (23%), Positives = 90/223 (40%), Gaps = 8/223 (3%)

Query: 199 EEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEP 258
             Y         +  KA      + + +        L  +      +  ++GP+   P  
Sbjct: 258 GIYRVSGVATDIQALKAAFDVKALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDP-- 315

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
           +L  +   F     + LS  + EK R+      G    A+  + +   P   +  P   L
Sbjct: 316 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP-SNYITPVNSL 374

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
           E   WYHG +SR  AE+LL      S+LVR SE+S    S+SL+      H +++   + 
Sbjct: 375 EKHSWYHGPVSRNAAEHLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDG 434

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           K  +   S  F+++ E+VHH+++    +      +L YP   R
Sbjct: 435 KLYVSSES-RFNTLAELVHHHST----VADGLITTLHYPAPKR 472


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  166 bits (419), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 54/245 (22%), Positives = 89/245 (36%), Gaps = 7/245 (2%)

Query: 178 EGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDS 237
                       +P          D   E ++ +                        +S
Sbjct: 111 NEALLQSRPLPHIPAGSTAASLLADAA-ELQQHQQDSGGLGLQGSSLGGGHSSTTSVFES 169

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA 297
           +      + ++  P     +P L  +   F+   ++ LS  + E+ R+     +G    A
Sbjct: 170 AHRWTSKE-NLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEA 228

Query: 298 KPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDF 357
              S         +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    
Sbjct: 229 HSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR 288

Query: 358 SLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLY 416
           S+SL+      H ++S   + K  + Q    F+++ E+VHH+    +P +G      LLY
Sbjct: 289 SISLRYEGRVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHH---SVPHEGHGLITPLLY 344

Query: 417 PVAIR 421
           P   +
Sbjct: 345 PAPKQ 349


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  162 bits (410), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 51/195 (26%), Positives = 82/195 (42%), Gaps = 6/195 (3%)

Query: 228 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP 287
                   +S+      + ++  P     +P L  +   F+   ++ LS  + E+ R+  
Sbjct: 159 HSSATSVFESAHRWTSKE-NLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILS 217

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
              +G    A   S         +  P   LE   WYHG ISR  AE LL      S+LV
Sbjct: 218 YNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLV 277

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           R SE+S    S+SL+      H ++S   + K  + Q    F+++ E+VHH+    +P +
Sbjct: 278 RESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHH---SVPHE 333

Query: 408 G-AEHMSLLYPVAIR 421
           G      LLYP   +
Sbjct: 334 GHGLITPLLYPAPKQ 348


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  161 bits (407), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 41/224 (18%), Positives = 79/224 (35%), Gaps = 11/224 (4%)

Query: 199 EEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEP 258
            E D+P     +RI       I V   +P  P        P        I    +     
Sbjct: 10  GEPDKP----ADRIKLDDPPTIGVGVGVPQIPMPSHAGQPPEQIRPVPQIPESETAGANA 65

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
            +  +   ++      LS  + E   +          +    +         +      +
Sbjct: 66  KIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEGYIPSNYVAKLKSI 125

Query: 319 ENQVWYHGAISRTDAEN--LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           E + WY   I R +AE   LL   +  ++L+R+SE+  ND+SLS++      H ++ +  
Sbjct: 126 EAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLD 185

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           E  + + + +  F ++ E+V HY+           ++L  P   
Sbjct: 186 EGGFFIARRT-TFRTLQELVEHYSKDS----DGLCVNLCKPCVQ 224


>UniRef50_UPI00006A214E SH2 domain-containing adapter protein E. n=1 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A214E
          Length = 437

 Score =  160 bits (405), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 118/418 (28%), Positives = 188/418 (44%), Gaps = 34/418 (8%)

Query: 4   EGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPI 63
           +     S+  ++ +L+ +R        R S +  L      +       L +   H   I
Sbjct: 52  KSRKNSSSEGQSKSLKDTR------LSRESLQSLLQGKGRKNSRDEGGGLRAPKGHSTYI 105

Query: 64  SSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAG 123
           +   +   +   +  +    +  +         ++   + I+E+YA P+D + T +    
Sbjct: 106 NRLIKVDPSLQDKNSRDIQETEEQPPEKDQDRPIKDETIIIIENYAIPYDAKCTKDPR-- 163

Query: 124 ASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAP 183
                E++ ENDGYMEPY+AQ+M+ EIR           L      P             
Sbjct: 164 ---DAERLGENDGYMEPYDAQQMITEIRRRGSKDNLITELLLLELGPPCG-------LKT 213

Query: 184 WPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPD 243
             R     E  +R P+ YD P+E                 +        G      +   
Sbjct: 214 VVRRPGSQELLDRAPQLYDTPYEPPDA---------GGEAEPQENKGSAGDGTRPENDER 264

Query: 244 GDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSME 303
              +   P     E  +   S QFE  E+   SP +EE GR   R  +  PK  K    E
Sbjct: 265 PAGEYEQPWEWKKEHIVRALSVQFENSER---SPSKEEPGRSHQRQKSWTPKVLKQHQAE 321

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKS 363
                G+  DP +PLE Q WYHG+++R  AE+LL  C EASYL+RNS +  + +S++LK+
Sbjct: 322 Q----GDKVDPTVPLEKQSWYHGSVTRDQAESLLDSCPEASYLLRNSGSGNSKYSIALKT 377

Query: 364 SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           SQG +H+ +++TK +K+ L Q    F+S+PE+VHHY+S+KLP KG++H+SLL+PV  +
Sbjct: 378 SQGCVHIIVAQTKNNKFTLSQMCGAFNSIPEVVHHYSSQKLPFKGSKHISLLHPVPSK 435


>UniRef50_C3ZPI6 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3ZPI6_BRAFL
          Length = 718

 Score =  160 bits (403), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 80/299 (26%), Positives = 132/299 (44%), Gaps = 23/299 (7%)

Query: 89  RIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPEND----GYMEPYEAQ 144
                    +P    +L+DY+DP+D+++    S      P+  P  +     Y +PY+AQ
Sbjct: 256 STPENTHVSKPMKPIVLDDYSDPYDIRKAVLESRDYDVPPDCRPPKEDDFNNYSDPYDAQ 315

Query: 145 KMMAEIR-GSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQ 203
           K++ E+R    + A +  P   TP   + +G++++      P E   PED +    +   
Sbjct: 316 KIIQELRIQQSKEAKEETPRSSTP---DSEGSSSDSALYEDPYEPSAPEDIDADTHQARL 372

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
             E +K + ++      +  +      P    D        +R     A+ L +      
Sbjct: 373 ARELEKAKETQLKQQQQQQQQPDEDTRPAEDYDQPWEWSSKERLSQAFAAQLDQQQPS-- 430

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
                 P  S  +P   +K       S+ +P S   +  + S    E  DP++PLE Q W
Sbjct: 431 ------PPPSTHTPPSADKRLAAVPESSASPLSKTRVFRKHSHEGSEPIDPSIPLEGQRW 484

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           YHG+ISR DAEN+LR C+E S+LVRNSE+S+ +FSLS+K             ++  Y L
Sbjct: 485 YHGSISRVDAENVLRSCRECSFLVRNSESSRTNFSLSIKMEDK-------ECRDRGYFL 536


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  159 bits (402), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 52/225 (23%), Positives = 87/225 (38%), Gaps = 6/225 (2%)

Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
           P         +     +     ++              +S+      + ++  P     +
Sbjct: 138 PAGSTAASLLENAAELQCSDSGLQCSSLGGHSSSTSVFESTHRWTSKE-NLLEPGPEEDD 196

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
           P L  +   F+   ++ LS  + E+ R+     +G    A   S         +  P   
Sbjct: 197 PQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNS 256

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H ++S   +
Sbjct: 257 LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPD 316

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAIR 421
            K  + Q    F+++ E+VHH+    +P +G      LLYP   +
Sbjct: 317 GKVFVTQE-AKFNTLAELVHHH---SVPHEGHGLITPLLYPAPKQ 357


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  159 bits (402), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 52/226 (23%), Positives = 87/226 (38%), Gaps = 6/226 (2%)

Query: 197 PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP 256
           P              + +   +   +             +S+      + ++  P     
Sbjct: 148 PAGSTAASLLADAAELQQDSGILSSMGGGGGHSSTTSVFESTHRWTSKE-NLLAPGPEED 206

Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
           +P L  +   F+   ++ LS  + E+ R+     +G    A   S         +  P  
Sbjct: 207 DPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLN 266

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
            LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H ++S   
Sbjct: 267 SLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDP 326

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAIR 421
           + K  + Q    F+++ E+VHH+    +P +G      LLYP   +
Sbjct: 327 DGKVFVTQE-AKFNTLAELVHHH---SVPHEGHGLITPLLYPAPKQ 368


>UniRef50_A4II17 Shd protein (Fragment) n=3 Tax=Xenopus (Silurana) tropicalis
           RepID=A4II17_XENTR
          Length = 379

 Score =  157 bits (397), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 89/306 (29%), Positives = 139/306 (45%), Gaps = 46/306 (15%)

Query: 117 TGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGAT 176
           + EG     G  E  PE+  YM+PYE+Q         +   T  L LYD PY+ ++   T
Sbjct: 119 SVEGKNELFGGEE--PEDIRYMDPYESQSTGLHCIMERAAGT-ALKLYDFPYQ-KQFHKT 174

Query: 177 AEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLD 236
             G        S+   +DERP +EYDQPWEWKK+ I++AFAV  +               
Sbjct: 175 FHG--------SQQHLEDERPADEYDQPWEWKKDDINRAFAVQFEG-------------- 212

Query: 237 SSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKS 296
                     D    +    E  L+ S+  F   +K+ LS   E            +PK 
Sbjct: 213 ---------SDWQQSSLTRTERLLQPSAKCFRRLQKNSLSSSPESST---------SPKQ 254

Query: 297 AKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
              L+ E  +   E      PL+ QVWYHG +S+ +AE  L+ CK  S+++R  +    +
Sbjct: 255 CAELTDECMAYSLEHGTLNPPLQTQVWYHGKLSKLEAEKYLQNCKPGSFVIRIEQDI--E 312

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           + +S++ S    H+K+   +   ++LG++ P F+ + E+V HY    L ++  E + L  
Sbjct: 313 YFMSVRGSHSTQHLKVKCIENEHFMLGESGPSFTCILELVEHYMKHPLLLQNEEQLFLQC 372

Query: 417 PVAIRT 422
           PV   T
Sbjct: 373 PVFTVT 378


>UniRef50_Q4RIA8 Chromosome 8 SCAF15044, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RIA8_TETNG
          Length = 253

 Score =  157 bits (397), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 98/320 (30%), Positives = 143/320 (44%), Gaps = 71/320 (22%)

Query: 102 LAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPL 161
           L ILEDYADPFD ++T E         E+   NDGYMEPY+AQ ++   RGSK+     +
Sbjct: 1   LIILEDYADPFDAEKTKEQREA-----ERAGVNDGYMEPYDAQVIITGERGSKDLLKVCV 55

Query: 162 PLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
            L                      RE +  E    P   YD P+E + +   +   + + 
Sbjct: 56  LL------------------DRGQREGKREEGHPLPLNIYDTPYEGELDGDREGVWIPVT 97

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
             +    PP   +L       D  R +S P                              
Sbjct: 98  RPESDIRPPGEYELPWEWRKEDIVRALSVP----------------------------HR 129

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 341
            GR      A   +S   +  E S                 WYHG++SR  AE  L+ C+
Sbjct: 130 MGRWLKWTPASPWRSRGEVGGEGS-----------------WYHGSVSRQQAEAQLQRCR 172

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK---YVLGQNSPPFSSVPEIVHH 398
           EAS+LVR+SE+  + +S++LK+SQ  +H+ +++TK  K   + L Q+S  F S+PE+VHH
Sbjct: 173 EASFLVRDSESGTSKYSIALKTSQSCVHIIVAQTKGVKGLGFTLDQSSCVFPSIPELVHH 232

Query: 399 YASRKLPIKGAEHMSLLYPV 418
           Y + +LP  GAEHM+L +PV
Sbjct: 233 YCTHRLPFTGAEHMTLQHPV 252


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  157 bits (397), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 51/225 (22%), Positives = 86/225 (38%), Gaps = 4/225 (1%)

Query: 197 PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP 256
           PP     P +   +    +      +             +++      + ++  P     
Sbjct: 72  PPPGSIIPGDVLAQSQDGSENHTGTLHSQGSSNTAQSSFENAHRWTSKE-NLLAPGPEED 130

Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
           +P L  +   F+   ++ LS  + E+ R+     +G    A   S         +  P  
Sbjct: 131 DPQLFVALYDFKAGGENQLSLRKGEQVRILSYNKSGEWCEAHSDSGHVGWVPSNYVTPLN 190

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
            LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H ++S   
Sbjct: 191 SLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDS 250

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           + K  +      F+++ E+VHH++   L         LLYP   +
Sbjct: 251 DGKVYVTAE-AKFNTLAELVHHHSV--LHEGHGLITPLLYPAPKQ 292


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  156 bits (394), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 89/232 (38%), Positives = 123/232 (53%), Gaps = 12/232 (5%)

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
             E+ + +         +    +    PV          D   D               S
Sbjct: 90  SQEFGRSKTPLNIVTFEEPQAPVVPSAPVVGETDYSDPFDARPDPRPRPGWEQNAVEACS 149

Query: 264 SA------------QFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
           S              FE  +    +   +E  R         P S      +P   LGE 
Sbjct: 150 SYMEPFEAQRFINVTFEAADWDQCTLPCDEALRKAGVSRVSPPSSGATSLRKPHGILGER 209

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
            DP LPLE QVWYHGA++R++AE+LL LCKE SYLVR S+TS+ND+SLSL+S  GFMHMK
Sbjct: 210 VDPMLPLEKQVWYHGALTRSEAESLLTLCKECSYLVRKSQTSRNDYSLSLRSCHGFMHMK 269

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            S++++ K++LG+NSPPF S+PE++H Y + KLPI+GAEH+SLL+PV ++TL
Sbjct: 270 FSQSRDGKFILGENSPPFDSIPEVIHFYTTNKLPIRGAEHLSLLFPVLVQTL 321


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  155 bits (391), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 48/229 (20%), Positives = 79/229 (34%), Gaps = 4/229 (1%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP 251
           E  E   +    P             +                 +   S+    ++    
Sbjct: 43  EHSEALLQSRPLPHIPDLPDGDPPGTIPSGGGSSGGSIGGTISSNLESSIRWTSKENLLQ 102

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
           +    +P L  +   F+    + LS  + E+ R+     +G    A     +       +
Sbjct: 103 SQEDDDPQLFVALYDFQAGGDNQLSLKKGEQVRILSYNKSGEWCEAHASPGQVGWVPSNY 162

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
             P   LE   WYHG ISR  AE LL      S+LVR SE+S    S+SL+      H +
Sbjct: 163 VTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 222

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           ++       V       F+++ E+VHH++     +       LLYP   
Sbjct: 223 INEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLIT----QLLYPAPK 267


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score =  155 bits (390), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 71/200 (35%), Positives = 110/200 (55%), Gaps = 4/200 (2%)

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
                     L  S         +S  +S L     +   A   G  K  L+    E G+
Sbjct: 641 PNRHTRNRAHLAVSRRWTTESSGLSQASSSLSMRDSDSKLALAGGFFKQSLTLNLNECGQ 700

Query: 285 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
            PP+           L++  + P  +  D ++PL+ Q WYHG+ISR DAE +LR   E S
Sbjct: 701 RPPKKFG---TLDLGLNLGTNRPNVDLIDASIPLDRQGWYHGSISRIDAEKILRPLSEGS 757

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRK 403
           +LVRNSE+++ D+SL+LKS++GFMHM++ R  +  +++LGQ S PF ++P+++ H+   +
Sbjct: 758 FLVRNSESTRQDYSLTLKSAKGFMHMRIQRDADSGQFILGQFSRPFPTIPDMIRHFCLNR 817

Query: 404 LPIKGAEHMSLLYPVAIRTL 423
           LP++GAEHM LL PV  + L
Sbjct: 818 LPVRGAEHMCLLEPVIAQIL 837


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score =  154 bits (388), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 87/343 (25%), Positives = 141/343 (41%), Gaps = 13/343 (3%)

Query: 82  WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
           +  T     +   ++L        +   +P         +  +     +           
Sbjct: 568 YCGTQNSSFLAHANKLHILSPISDKSSQEPISETSDNNRNNNSQKCSPEE------AATP 621

Query: 142 EAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEY 201
           E  K+   +  +K          D   +  + G + +         SR  +  + P   +
Sbjct: 622 ETMKVKRRLPQNKNLLNLGFHAGDLEIQGSDSGISIQSREGIK---SRQQDFSDLP---F 675

Query: 202 DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLE 261
           D P   ++  I++                P         L       S  +      S+ 
Sbjct: 676 DMPKLRRRRMITQDACTSGSATSVDLRDLPFDMPKLRRRLRIQPSTESSVSQASSSQSVI 735

Query: 262 DSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQ 321
           ++  Q             E   R  P L          L+   + P  +  D  LPLE Q
Sbjct: 736 EADRQVSSFRPKLTLNLGELDLRQRPGLGLSLVGLGMNLNNPENPPTADVIDVNLPLEKQ 795

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK-EHKY 380
            W+HGAI+R +AEN+LR+ +E S+LVRNSE++K D+SLSLKS++GFMHM++ +   +  Y
Sbjct: 796 GWFHGAITRVEAENVLRMLREGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDGNDECY 855

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           +LGQ S PF S+PE++ H+   +LPI+GAEHM LL PV  + L
Sbjct: 856 ILGQFSKPFHSIPEMIRHFCINRLPIRGAEHMCLLQPVIAQLL 898


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  154 bits (387), Expect = 8e-36,   Method: Composition-based stats.
 Identities = 49/212 (23%), Positives = 90/212 (42%), Gaps = 8/212 (3%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
           +  +   +++  + + +        L  +      +  ++GP+   P  +L  +   F  
Sbjct: 356 KDPTTKNSLEKALQRPVASDFEPQGLSEAARWNSKEDLLAGPSENDP--NLFVALYDFVA 413

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
              + LS  + EK R+      G    A+  + +   P   +  P   LE   WYHG +S
Sbjct: 414 SGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP-SNYITPVNSLEKHSWYHGPVS 472

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R  AE LL      S+LVR SE+S    S+SL+      H +++   + K  +   S  F
Sbjct: 473 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSES-RF 531

Query: 390 SSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +++ E+VHH+++    +      +L YP   R
Sbjct: 532 NTLAELVHHHST----VADGLITTLHYPAPKR 559


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  153 bits (386), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 51/213 (23%), Positives = 83/213 (38%), Gaps = 10/213 (4%)

Query: 212 ISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS----PLPEPSLEDSSAQF 267
           +   F  D                D  P   +     S   +       +P+L  +   F
Sbjct: 59  VEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDF 118

Query: 268 EGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGA 327
                + LS  + EK R+      G     +  + +   P   +  P   LE   WYHG 
Sbjct: 119 VASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVP-SNYITPVNSLEKHSWYHGP 177

Query: 328 ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
           +SR+ AE LL      S+LVR SE+S    S+SL+      H +++ T + K  +   S 
Sbjct: 178 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAES- 236

Query: 388 PFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            FS++ E+VHH+++    +      +L YP   
Sbjct: 237 RFSTLAELVHHHST----VADGLVTTLHYPAPK 265


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 39/242 (16%), Positives = 82/242 (33%), Gaps = 8/242 (3%)

Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
                 ++   E  + P E  D        +++    V       +     +     +  
Sbjct: 6   SRSASSKNTKKEVVQAPVERGDVS-SINIGQVTTHEPVGSGGGGGVRSGHHIELGGRNGP 64

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
                       S      +  +   ++      LS  + E   +          +    
Sbjct: 65  TIPSAVPPEVETSAATGTKIFVALYDYDARTDEDLSFKKGEHLDILNDTQGDWWFARSKS 124

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN--LLRLCKEASYLVRNSETSKNDFS 358
           + +       +      +E + WY G I R +AE   LL   +  ++LVR+SE+ +NDFS
Sbjct: 125 TKQEGYIPSNYVAKLKSIEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSESRRNDFS 184

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           LS++      H ++ +  E  + + + +  F ++ E+V HY +          ++L  P 
Sbjct: 185 LSVRDGDTVKHYRIRQLDEGGFFIARRT-TFRTLQELVDHYGNE----ADGLCVNLRKPC 239

Query: 419 AI 420
             
Sbjct: 240 VQ 241


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 49/202 (24%), Positives = 85/202 (42%), Gaps = 8/202 (3%)

Query: 220 IKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGR 279
             + + +        L  +      +  ++GP+   P  +L  +   F     + LS  +
Sbjct: 27  EALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDP--NLFVALYDFVASGDNTLSITK 84

Query: 280 EEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL 339
            EK R+      G    A+  + +   P   +  P   LE   WYHG +SR  AE LL  
Sbjct: 85  GEKLRVLGYNHNGEWCEAQTKNGQGWVP-SNYITPVNSLEKHSWYHGPVSRNAAEYLLSS 143

Query: 340 CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
               S+LVR SE+S    S+SL+      H +++   + K  +   S  F+++ E+VHH+
Sbjct: 144 GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSES-RFNTLAELVHHH 202

Query: 400 ASRKLPIKGAEHMSLLYPVAIR 421
           ++    +      +L YP   R
Sbjct: 203 ST----VADGLITTLHYPAPKR 220


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 78/405 (19%), Positives = 130/405 (32%), Gaps = 56/405 (13%)

Query: 22  RQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSN 81
           +QGS G      P G   +A P  +  +  P NS  A     SS+P+    GP+     +
Sbjct: 164 QQGSGGSSPVGPPPGY--TANPPPYFDSNHPSNSSQA-----SSNPR----GPQGATPGH 212

Query: 82  WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
              T RL  I         P       +   +   T   +       ++   N+   +P 
Sbjct: 213 QPMTGRLIDID------SEPPIYGATASPSRNNGPTALDNPLQRSCKQRPTHNNNIKKP- 265

Query: 142 EAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEY 201
                      S++   +   LYD P                 P E    ++    P+  
Sbjct: 266 -----------SRKAKRRTPSLYDNP---PTKEDVEAKVKQLTPAERNQYQNIIANPD-- 309

Query: 202 DQPWEWKKERISKAFAVDI----KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
                WKK   S    + +    K  K +       Q     ++     D          
Sbjct: 310 -----WKKLVDSGYDNLRMLNVWKQSKSVMLHKGGDQEGEYANVACFHDDHDDDDDDDEH 364

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
            +  D   + E           E   +            A            +   P  P
Sbjct: 365 GNRNDGEEEEEEEVDDAQPFNPEAAKQPSNPS-------AGGGGGASGLHPHDMAPPTNP 417

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L N+ W+HG +SR + E LL    +  +LVR S T+K+ + LS   +    H+ L    +
Sbjct: 418 LYNEEWFHGPMSRKEGEPLLSN--DGDFLVRESTTAKDQYVLSGMQNGTPKHLLLV-DPQ 474

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVAIR 421
            K  +      F SV  +++++ + +LPI  A   + L  PV  +
Sbjct: 475 GK--VRTKDKEFDSVSHLINYHRNNRLPIISAGSAVHLKTPVVRK 517


>UniRef50_UPI00017930CA PREDICTED: similar to SH2 domain containing 4A n=1
           Tax=Acyrthosiphon pisum RepID=UPI00017930CA
          Length = 410

 Score =  151 bits (381), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 57/369 (15%), Positives = 121/369 (32%), Gaps = 25/369 (6%)

Query: 74  PKQKKKSNWRSTTRLRIIRLRDRLEPRPLA-ILEDYADPFD--VQETGEGSAGASGAPEK 130
            + ++ S W     ++   L+ +   + +  +L+   +P+   + E  +         E+
Sbjct: 34  EQVRRWSVWDHNEGIKPAYLKRQKNNKKVQWMLDTNGNPWTWIMGEHKDDKTIEQIIEEE 93

Query: 131 VPENDGYMEPYEAQKMMAEIRGS-KETATQPLPLYDTPYEPEEDGATAE---GEGAPWPR 186
             E       +E +++  ++                 P E +   AT E          R
Sbjct: 94  AREAARIQAEHETEQLRLKVESELMAMLESKAKTQFNPPENKYSHATEEIYCSVEDLNAR 153

Query: 187 ESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDR 246
            +R P    +P     +  E    ++S+        + +        ++ +     +   
Sbjct: 154 NARKPSVATQPMRGALK--ELSFNKVSERVRNWEHRVMEERTSEIYNKMKNKKEEEERQA 211

Query: 247 DISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP----PRLSAGNPKSAKPLSM 302
           + +     +     +  + + E   +      REE  R       + S            
Sbjct: 212 EEADKKQDIVWREQKQKAKEVELQIRQIARQAREEHRRSLLNTSEKPSNVVFVPNSSKPP 271

Query: 303 EPSSPLGEWTDPALPLENQV---------WYHGAISRTDAENLLRLCKEASYLVRNSETS 353
              + +  +    +P              W+HG I+R +AE LL      S+LVR SE  
Sbjct: 272 SKKAVVEWFRAKEIPRRAGFEKDKNAIATWFHGLITRQEAEILLINEPVGSFLVRLSERI 331

Query: 354 KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS 413
              ++++ K      H  +  +  H   LG N    +++ E+V ++ S  +   G E   
Sbjct: 332 WG-YAITYKDHDCCKHYLVDASNGHYQFLGTNQISHNTLSELVSYHRSMPITKTGEE--L 388

Query: 414 LLYPVAIRT 422
           LL P    T
Sbjct: 389 LLRPCNRTT 397


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  151 bits (381), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 52/273 (19%), Positives = 99/273 (36%), Gaps = 20/273 (7%)

Query: 162 PLYDTPY-EPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI 220
           P++D P   P+ + ++   E     +   + E   R P+              +    D 
Sbjct: 22  PVFDQPVASPKSEISSKLAEEIERSKSPLILEVSPRTPDSVQMFR--PTFDTFRPPNSDS 79

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
              +       +    S  S+ +     +  +S      L  +   F G  +  LS  + 
Sbjct: 80  STFRGSQSREDLVACSSMNSVNNVHDMNTVSSSSSSSAPLFVALYDFHGVGEEQLSLRKG 139

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSP------------LGEWTDPALPLENQVWYHGAI 328
           ++ R+           A+  S   +                 +  P   L+   WYHG I
Sbjct: 140 DQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYNSLDKYTWYHGKI 199

Query: 329 SRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP 388
           SR+D+E +L      S+LVR SETS   +++S++      H +++     K  + Q    
Sbjct: 200 SRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQE-VK 258

Query: 389 FSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           F ++ E+VHH++             L+YP + +
Sbjct: 259 FRTLGELVHHHSVH----ADGLICLLMYPASKK 287


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  151 bits (380), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 47/224 (20%), Positives = 79/224 (35%), Gaps = 15/224 (6%)

Query: 197 PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP 256
           P   Y+  + ++         V+       P  P   Q   S       R+         
Sbjct: 9   PAVGYNGEFFFQPRSDDSDEEVESDAAAAGPSQPGSRQRQPSHRADRYPREPQ------- 61

Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
              +      F+G  +  LS  R EK  L  RL           S +       +  P  
Sbjct: 62  VGDVFVGVYNFQGRTEPELSFERGEKLTLLRRLDENWWLMRSQRSGKEGYAPSNYIAPFK 121

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM-HMKLSRT 375
            +    WYH  ISR  AE LL+   + S+LVR S +S  ++S++L+       H +++  
Sbjct: 122 DINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGEYSITLRCDGKARTHYRINHD 181

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL-YPV 418
               +V       F++V ++V H+      +       L  +PV
Sbjct: 182 ARGYFVAA--GKFFATVEQLVAHH----AVVADGLVACLKQHPV 219


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  150 bits (379), Expect = 7e-35,   Method: Composition-based stats.
 Identities = 46/241 (19%), Positives = 83/241 (34%), Gaps = 12/241 (4%)

Query: 169 EPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPW 228
           E +        E  P P  + +      P      P    K       ++ +        
Sbjct: 8   ENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSG 67

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
             P G   SS S+         PA      ++  +   +E      LS  + E+ ++   
Sbjct: 68  VTPFGGASSSFSVVPSSY----PAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINN 123

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYL 346
                 ++    + +       +  PA  ++ + WY G + R DAE LL         +L
Sbjct: 124 TEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFL 183

Query: 347 VRNSETSKNDFSLSLK-----SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           VR SET+K  +SLS++           H K+ +     Y +   +  F ++ ++V HY  
Sbjct: 184 VRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQ-FDTLQKLVKHYTE 242

Query: 402 R 402
            
Sbjct: 243 H 243


>UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=Euteleostomi
           RepID=SHD_HUMAN
          Length = 340

 Score =  150 bits (378), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 117/376 (31%), Positives = 160/376 (42%), Gaps = 86/376 (22%)

Query: 52  PLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRL-----EPRPLAILE 106
           P     +  EP  + P    N    K  S      ++    +             L    
Sbjct: 45  PYEDAESRLEPDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEADT 104

Query: 107 DYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDT 166
           +Y DPFD Q            P   P +DGYMEPY+AQ +M+E+        + + LYDT
Sbjct: 105 EYLDPFDAQ------------PHPAPPDDGYMEPYDAQWVMSELP------GRGVQLYDT 146

Query: 167 PYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDL 226
           PYE ++                         P +   P E ++                 
Sbjct: 147 PYEEQDPETADGPPSGQK-------------PRQSRMPQEDER----------------- 176

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
                               +   P     +      + QF+ PE        +E     
Sbjct: 177 -----------------PADEYDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKE----- 214

Query: 287 PRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
                             S    E  DPALPLE Q W+HG ++R DAE+LL LCKE SYL
Sbjct: 215 -----------LRRPPPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYL 263

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           VR SET+  D SLSL+SSQGF+H+K +RT+E++ VLGQ+S PF SVPE+V HY+SR LP+
Sbjct: 264 VRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPV 323

Query: 407 KGAEHMSLLYPVAIRT 422
           +GAEH++LLYPV  +T
Sbjct: 324 QGAEHLALLYPVVTQT 339


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  149 bits (374), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 36/198 (18%), Positives = 62/198 (31%), Gaps = 21/198 (10%)

Query: 239 PSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK 298
            +                +    +++  F G  K  L   + +   +       N    +
Sbjct: 2   SARAKEPEGARPDILKPTKGMKCEAAYDFNGASKEDLPFKKGDILTIENPTEDPNWWLVR 61

Query: 299 PLSMEPSSPLGEWT---------------DPALPLENQVWYHGAISRTDAENLLRLCKEA 343
             +         +                D +  L    W+HG ISR  AE+LL   ++ 
Sbjct: 62  DKTGRTGMIPANYVELIGSDTKKTGTLPRDASGQLIPMPWFHGKISRELAESLLMPREDG 121

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
            +LVR S     D++L +       H +  + K  K  +      FSS+ E+V HY    
Sbjct: 122 LFLVRESAHFPGDYTLCVCFQDQVDHYR-MQGKNGKLTI-DEEVYFSSLEELVQHYEKD- 178

Query: 404 LPIKGAEHMSLLYPVAIR 421
                     L  PV  +
Sbjct: 179 ---ADGLCTRLRKPVVKQ 193


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  148 bits (373), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 36/180 (20%), Positives = 70/180 (38%), Gaps = 7/180 (3%)

Query: 243 DGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSM 302
           +   +I+ P    P  ++  +   +E      LS  + E+ ++          +   ++ 
Sbjct: 46  NQPPNINPPMLGGPGVTIFVALYDYEARISEDLSFKKGERLQIINTADGDWWYARSLITN 105

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLS 360
                   +  P    E + WY G + R +AE  L  R     ++L+R +ET+  +FSLS
Sbjct: 106 SEGYIPSTYVAPEKSYEAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAETAVGNFSLS 165

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           ++      H ++ +     Y +     PF+S+ E+V HY             +L  P   
Sbjct: 166 VRDGDSVKHYRVRKLDTGGYFITTR-APFNSLYELVQHYTKD----ADGLVCALTLPCPK 220


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score =  148 bits (372), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 66/115 (57%), Positives = 90/115 (78%), Gaps = 1/115 (0%)

Query: 310  EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
            +  DP+LPLE Q WYHG+I+R +AE+LLR  KE SYLVRNSE++K D+SLSLKS++GFMH
Sbjct: 1081 DLIDPSLPLEKQTWYHGSITRVEAEDLLRSLKEGSYLVRNSESAKQDYSLSLKSAKGFMH 1140

Query: 370  MKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            M++       +++LGQ S PF+S+P+++ HY+  KLPI+GAEHM LL PVA + L
Sbjct: 1141 MRIQIDNNSGQFILGQFSKPFNSIPDMIRHYSVNKLPIRGAEHMCLLKPVAAQLL 1195


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  147 bits (371), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 78/348 (22%), Positives = 134/348 (38%), Gaps = 29/348 (8%)

Query: 79  KSNW--RSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDG 136
            SN+  R  +      + D L+ + L       DPFD     +     SGA   +     
Sbjct: 52  PSNYLARKDSNKGKKNIIDNLKSKVLKNKRTSIDPFDSVTDVQNIKSKSGAKVLMVAFSK 111

Query: 137 YMEPYEAQKMMAEIRGSKETATQPLPL-YDTPYEPEEDGATAEGEGAPWPRESRLPEDDE 195
           +   Y  Q+   E+  ++      + + +D     E +G              +  E  +
Sbjct: 112 FK--YTPQR-DDELELNRGDQVLVIEMEHDGWCRGECNGKVGWFPFNYI----QKVESSD 164

Query: 196 RPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPL 255
               EY  P +   +           +I  +    P           D D  +     P 
Sbjct: 165 GSTSEYADPSDVMDK----------PIISKVRTLYPFKSQSKEELSFDKDIILEIIDKPK 214

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKP-LSMEPSSPLGEWTDP 314
            +P   D     +   +  L P    +  + P L+ G  K      S+  + P+ +   P
Sbjct: 215 DDP---DWWRARKSNGEIGLVPRNYVEEIVSPVLTPGPTKPKHSISSLNTNPPIVKDETP 271

Query: 315 ALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
                ++ WYHG +SR++ E LL    K+  YL+RNSE+   DFSLS+K+     H K+ 
Sbjct: 272 DCIFRDKDWYHGTLSRSECEFLLNEHAKDGEYLIRNSESKPGDFSLSMKAPNRIKHFKIL 331

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPVAI 420
               ++YV+GQ S  FS++ E++ HY +  +   +  + M LLYP+  
Sbjct: 332 Y-GNNQYVIGQRS--FSNIDELLSHYKNYPIYTTENGQKMHLLYPLNK 376


>UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=Euteleostomi
           RepID=SHD_MOUSE
          Length = 343

 Score =  144 bits (363), Expect = 5e-33,   Method: Composition-based stats.
 Identities = 99/316 (31%), Positives = 136/316 (43%), Gaps = 38/316 (12%)

Query: 107 DYADPF-DVQETGEGSAGASGAPEKVPENDGYM--EPYEAQKMMAEIRGSKETATQPLPL 163
           D+ DP+ D     E     SG P+        +  E  +  +  A +    E        
Sbjct: 41  DFEDPYEDSNGRAEPEVTGSGDPKYNSPRHRLIKVEAADMARAKALLGSPGEEPEAETEY 100

Query: 164 YDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVI 223
            D      +  A   G   P+   S   E   R  + YD P+E              +  
Sbjct: 101 SDPFDAQPQPPAPNSGYMEPYDARSVSSEQPSRAVQLYDTPYE--------------EQA 146

Query: 224 KDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKG 283
                    GQ            +   P     +      + QF+GP+        +E  
Sbjct: 147 TKPEDGGSSGQSRRPLEDERPADEYDQPWEWKKDHISRAFAVQFDGPDWERTPCSTKEPW 206

Query: 284 RLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEA 343
           R  P                      E  D AL LE Q W+HG +SR +AENLL LCKE 
Sbjct: 207 RPQP---------------------AERVDTALALEKQPWFHGPLSRAEAENLLSLCKEG 245

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
           SYLVR SET   D  LSL+S+QG MH+K +RT+E++ VLGQ+S PF S+PE+V HY++R 
Sbjct: 246 SYLVRLSETRAQDCILSLRSNQGSMHLKFARTRENQVVLGQHSGPFPSIPELVLHYSARP 305

Query: 404 LPIKGAEHMSLLYPVA 419
           LP++GAEH++LLYPV 
Sbjct: 306 LPVQGAEHLALLYPVT 321


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  144 bits (362), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 59/353 (16%), Positives = 106/353 (30%), Gaps = 20/353 (5%)

Query: 76  QKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPEND 135
           Q  + N RS     +  L    + R       Y D          S  + G     P   
Sbjct: 95  QSPERNDRSAWVQALQALLLPAK-RSKMFHPSYYDGKIWLCCKVESQDSEGCQSVTPIIK 153

Query: 136 GYMEPYEAQ------KMMAEIRGSKETATQPLPLYDTPYE--PEEDGATAEGEGAPWPRE 187
               P  A        +          +     ++  P    P+  G  +  E  P    
Sbjct: 154 ASTAPTNAGMQFGGGPVQPMPTMVPGLSMPAPSMHGMPPPTGPKPSGRLSAPEAPPAASL 213

Query: 188 SRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD 247
              P            P   K  R +      +   K       +     +         
Sbjct: 214 PPKPAALL--AAVMTGPGSPKAMRHAMEAPPMVTAPKPAALLASMRGPSGASPTSPAPAS 271

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
                + +PE         +       L+  ++E   +       N   A+    E    
Sbjct: 272 SPVAPAVVPERKQVRVMFDYIATAAGDLTIHKDEMITILEER--PNWWKAQNKHGEVGFV 329

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQG 366
              +      LE + W+ G ISR +A  +L+   +E  +LVR SET   +++LSL  ++G
Sbjct: 330 PSNYLCRIQGLEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEG 389

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
             H ++    E +Y + +N   F S+P+++ ++        G     L   + 
Sbjct: 390 VRHYRIQHI-EGQYFVNENH-RFDSIPQLIEYHKLNG----GGIVTRLRRAIN 436


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  143 bits (361), Expect = 9e-33,   Method: Composition-based stats.
 Identities = 35/168 (20%), Positives = 66/168 (39%), Gaps = 12/168 (7%)

Query: 260 LEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLE 319
           L  +   +E   +  LS  + EK ++         ++    + E       +  P   ++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 320 NQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKS-----SQGFMHMKL 372
            + WY G + R DAE  L        ++L+R SET+K  +SLS++           H K+
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            +     Y +   +  F ++ ++V HY+ R           L+ P   
Sbjct: 206 RKLDNGGYYITTRAQ-FETLQQLVQHYSER----AAGLCCRLVVPCHK 248


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  142 bits (358), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 51/205 (24%), Positives = 81/205 (39%), Gaps = 6/205 (2%)

Query: 217 AVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLS 276
                        P      +SP +   +           +P L      F G  ++ L+
Sbjct: 80  DNFPSDTIQSRPLPSTPTHATSPDIAGWNSTEDVCGGDEHDPDLFVVLYDFNGGVENQLT 139

Query: 277 PGREEKGRLPPRLSAGNPKSAKPL-SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN 335
             + +  R+      G    AK L + +       +  P   LE   WYHG ISR  AE 
Sbjct: 140 VRKGDHVRILGYNKGGEWCEAKKLKNGKTGWVPVTYVTPFNSLEKHSWYHGPISRNAAEY 199

Query: 336 LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEI 395
           LL    + S+LVR+SE+S    S+SL+      H ++S   + K  +   S  FS++ E+
Sbjct: 200 LLSSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGSDGKVFVTTES-KFSTIAEL 258

Query: 396 VHHYASRKLPIKGAEHMSLLYPVAI 420
           VHH+  +   +      +L YP A 
Sbjct: 259 VHHHCKQSDGLIT----TLRYPAAK 279


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  142 bits (356), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 41/204 (20%), Positives = 70/204 (34%), Gaps = 15/204 (7%)

Query: 226 LPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRL 285
            P+ P +       ++ +    +  P           +   ++      LS    +K ++
Sbjct: 13  EPYLPCLSTEADKSTVIENPGALCSP-QSQRHGHYFVALFDYQARTAEDLSFRAGDKLQV 71

Query: 286 PPRLSAGNPKSAKPLSME-------PSSPLGEWTDPALPLENQVWYHGAISRTDAEN--L 336
              L  G   +                     +      L+ + W+ GAI R+DAE   L
Sbjct: 72  LDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLL 131

Query: 337 LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
               K  S+L+R SE+ K +FSLS+       H ++ R  E  + L      FS++ E V
Sbjct: 132 YSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFL-TRRRIFSTLNEFV 190

Query: 397 HHYASRKLPIKGAEHMSLLYPVAI 420
            HY            + L  P   
Sbjct: 191 SHYTKTS----DGLCVKLGKPCLK 210


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  140 bits (353), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 38/204 (18%), Positives = 75/204 (36%), Gaps = 17/204 (8%)

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
             P G+L  +  +  G    +   + +P  +  +    F    K  L   + +   +  R
Sbjct: 3   HVPTGKLIDTGPVTRGPSYENHSLTTIPNGTTCEGVFDFNTGNKGDLPFKKGDTLVVIQR 62

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALP-----------LENQVWYHGAISRTDAENLL 337
               N   A+    E       +   +             L    W+HG I+R+DAE+LL
Sbjct: 63  TRDPNWYRAQNSKGESGMVPLNYITQSNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLL 122

Query: 338 RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
              K+  +LVR S     D+++ +  +    H ++   K++K  +      F ++ ++V 
Sbjct: 123 TPRKDGLFLVRESTNYPGDYTMCVSFAGEVEHYRVIF-KDNKVTI-DEEEYFENLTKLVE 180

Query: 398 HYASRKLPIKGAEHMSLLYPVAIR 421
           HY             +L  P+  +
Sbjct: 181 HYERD----ADGLVCTLTQPLIKK 200


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  140 bits (352), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 38/194 (19%), Positives = 73/194 (37%), Gaps = 11/194 (5%)

Query: 235 LDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNP 294
           + +S S   G+      +   P  +   +   F+G  +  L   + +   +       N 
Sbjct: 1   MSNSMSGNSGNPMSGNSSKNFPNGTECVARYDFKGNSEKDLPFKKGDIIEILQSTRDPNW 60

Query: 295 KSAKPLS-MEPSSPLGEWTDP--ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSE 351
            +AK +S          +     AL L    W+ G I+R  AE LL   +   +LVR S 
Sbjct: 61  YNAKKVSDGRTGLIPINYVQQRRALHLHEMPWFFGKITREKAEELLTPREVGLFLVREST 120

Query: 352 TSKNDFSLSLKS---SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG 408
               D++L + S   ++   H ++  T +++  +      F ++ E++ HY         
Sbjct: 121 NFPGDYTLCVVSPQNNKKVEHYRVISTSDNQVTV-DEEAFFPTLIELIKHYEKD----AD 175

Query: 409 AEHMSLLYPVAIRT 422
                L  P+  +T
Sbjct: 176 GLCTMLKKPLKKKT 189


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  140 bits (351), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 35/163 (21%), Positives = 64/163 (39%), Gaps = 8/163 (4%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA-KPLSMEPSSPLGEWTDPALP 317
            +      ++      LS  + +   +          +  K  + +       +      
Sbjct: 57  PIYVGKYDYDSRTDDDLSFKKGDLMYIISTDEGDWWFARSKDTAGKEGYIPSNYVAEYKS 116

Query: 318 LENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           L+ + W+ G I R +AE +L     +  S+L+R+SET+  DFSLS+K      H ++ R 
Sbjct: 117 LDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRL 176

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           ++    + + S  F  + E+V HY              LLYP 
Sbjct: 177 EDGSLFVTRRS-TFQILHELVDHYKIE----TDGLCCKLLYPC 214


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  138 bits (348), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 38/186 (20%), Positives = 69/186 (37%), Gaps = 12/186 (6%)

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
            P  +     P  P     +  +   ++      L+  + +   +    +     +    
Sbjct: 48  QPRLESPPPTPPFPDNTAKVVVAVYDYDARLDDDLTFVKGDLLEIREDTTD-WWYARSRK 106

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKND-- 356
           + +     G +  P   LE + WY G I R DAE LL     ++ S+L+R SE       
Sbjct: 107 NGKKGYIPGNYVAPIQTLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSENKNGQVS 166

Query: 357 --FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
             F+LS++  +   H ++  T   KY +   S  FS++ E++  Y            + L
Sbjct: 167 NCFALSVRDKELIRHYRIKITDSGKYFISL-SKEFSTLNELIEFYKISS----DGLKIKL 221

Query: 415 LYPVAI 420
           L P   
Sbjct: 222 LEPCRK 227


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  138 bits (348), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 41/153 (26%), Positives = 70/153 (45%), Gaps = 9/153 (5%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F       LS  + +  ++       N   A+    E   P        + ++N  
Sbjct: 5   AKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIP-----SNYIEMKNHD 59

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WY+G I+R DAE LL    E ++L+R SE+S  DFSLS+K   G  H K+ R  + K+ L
Sbjct: 60  WYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFL 119

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
                 F+S+ E+V ++ +    +  ++ + L 
Sbjct: 120 WV--VKFNSLNELVEYHRTAS--VSRSQDVKLR 148


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  138 bits (347), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 37/174 (21%), Positives = 73/174 (41%), Gaps = 9/174 (5%)

Query: 246 RDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPS 305
              S P    P      S   ++  E + LS  + E+  +  ++     K A+  + +  
Sbjct: 207 SPASLPPGAAPALFEVQSLYDYDALEPTDLSLSKGERLVIVDQMEEHWWK-ARNNAGQEG 265

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSS 364
                +    L LE++ W+    S+  A  LL +C ++ ++LVR SE++   +SLS+   
Sbjct: 266 YIPANYVR-KLGLESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLSVFYQ 324

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
               H K+   ++  Y + +    F+S+ E++ ++        G     L  PV
Sbjct: 325 GKLKHYKIKHDQD-MYRVSERH-TFASISELIEYHKHNG----GGLVTRLRKPV 372


>UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017925DF
          Length = 555

 Score =  138 bits (347), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 78/318 (24%), Positives = 131/318 (41%), Gaps = 32/318 (10%)

Query: 133 ENDGYMEPYEAQKMMAEIRGSKETATQPLPLY-----------DTPYEPEEDGATAEGEG 181
             D Y E  +    M ++R  +++   P  ++           D    P       EG  
Sbjct: 239 PGDNYQELLDVPFDMPKLRRRQKSEEGPTTVFSTTSSSSSSSSDCAGRPALAPPRPEGLP 298

Query: 182 APWPRESRLPEDDERPPEEYDQPWEWKKER---------------ISKAFAVDIKVIKDL 226
              P+  R   +    P   + P++  K R                  +          +
Sbjct: 299 FDMPKLRRRQTNAGCGPGGVELPFDMPKLRKRQMDSCARVISLDFEIGSDEEAYSARSGV 358

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLP 286
             P    + +    LP     +        +    D S  F     +  +       +L 
Sbjct: 359 RHPADRTKSEQLEELPFDIPKLKKINLHNEDEKKPDRSTLFLNVLPNNCAAVNANNKQLS 418

Query: 287 PRLSAGNPKSAKPLSMEPSSPLG--EWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
                 N  +   LS+    PL   E  D +LPL+ Q WYHG ++R +AE  L   KE +
Sbjct: 419 KTFQNKNQPNRPTLSLCNIKPLNFVEDIDVSLPLDQQCWYHGPMNRLEAEKALHGQKEGT 478

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           YLVR    +K  ++LS+KS++GF+HM++++++E  Y LGQ+  PF ++P+++ HY   KL
Sbjct: 479 YLVR---GNKGSYALSIKSAKGFIHMRITQSEERNY-LGQSDRPFETIPDLIKHYTLNKL 534

Query: 405 PIKGAEHMSLLYPVAIRT 422
           P KGAEH+ L+ P+A + 
Sbjct: 535 PAKGAEHVGLIRPLAHQV 552


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score =  138 bits (347), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 69/140 (49%), Positives = 96/140 (68%), Gaps = 1/140 (0%)

Query: 285  LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
              P    G      PL +  +    +  D  LPLE Q WYHG+I+R +AE +LRL +E S
Sbjct: 983  QLPPKKPGGLSLGLPLEINTARGSADLVDVGLPLERQGWYHGSITRIEAEAVLRLLREGS 1042

Query: 345  YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRK 403
            YLVRNSE++K D+SLSLKS++GFMHM++ + +E + Y+LGQ S PF S+PE+V H++  +
Sbjct: 1043 YLVRNSESTKQDYSLSLKSARGFMHMRIQKNEELNAYILGQFSKPFDSIPEMVRHFSVNR 1102

Query: 404  LPIKGAEHMSLLYPVAIRTL 423
            LPI+GAEHM LL+PV  + L
Sbjct: 1103 LPIRGAEHMCLLHPVIAQLL 1122


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score =  137 bits (343), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 97/392 (24%), Positives = 158/392 (40%), Gaps = 23/392 (5%)

Query: 33   SPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIR 92
            SP    SS +P S     +  NS    +E I++S        + +  +   ST   R   
Sbjct: 712  SPISDKSSQEPGSETSDINRNNSQKQSQEEINASGTLKKENDENETAAVKTSTVPKRRSA 771

Query: 93   LRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRG 152
                L    L I        D   +                   ++     +  +   + 
Sbjct: 772  PNKAL----LLITGPEIQGSDSGISLHSREDVKSRT-------NFLNLGIQRASLGLEKS 820

Query: 153  SKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERI 212
                 T P    D P++                ++           +  D P++  K R 
Sbjct: 821  DSGKPTLPQEFSDLPFDMP-----KLRRRRAHMQQESCTSGSVTSVDVGDLPFDMPKLR- 874

Query: 213  SKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK 272
             +      + I+ L  P   G L  + +   G    S   S     +   + A   G  K
Sbjct: 875  RRLRMPQNQQIQQLAVPSTSGILLQTSTESSGLSQASSSLSMRDSDNRAAALA--GGFFK 932

Query: 273  SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
              L+    E    P +           L+   +    +  D ++ L+ Q WYHG+ISR D
Sbjct: 933  QSLTLNLNECSAKPVKKFG---TLDFGLNFNTARSNVDLIDASISLDRQGWYHGSISRID 989

Query: 333  AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSS 391
            AE +LR   E S+LVRNSE+++ D+SL+LKS++GFMHM++ R  +  +Y+LGQ S PF +
Sbjct: 990  AEKILRPLGEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDPDSSQYILGQFSRPFPT 1049

Query: 392  VPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            +P+++ H+   +LP++GAEHM LL PV  + L
Sbjct: 1050 IPDMIRHFCLNRLPVRGAEHMCLLEPVIAQIL 1081


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  137 bits (343), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 30/156 (19%), Positives = 58/156 (37%), Gaps = 9/156 (5%)

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
           P  +  +  +   ++G     LS  + EK ++         K+    +         +  
Sbjct: 109 PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLSTKREGFIPSNYVA 167

Query: 314 PALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLK-----SSQG 366
               LE + W+   I+R DAE  L        ++L+R SET K  +SLS++         
Sbjct: 168 KVNTLETEEWFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDV 227

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
             H K+       Y +      F  + +++ +Y + 
Sbjct: 228 IKHYKIRSLDNGGYYIS-PRITFPCISDMIKYYQTN 262


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  136 bits (342), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 32/176 (18%), Positives = 56/176 (31%), Gaps = 12/176 (6%)

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
           +S   +  P  +   +   F G  +  L   + +   +       N   AK         
Sbjct: 1   MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60

Query: 308 LGEWTDPAL------PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSL 361
              +            L    W+HG I+R  AE LL   +   +LVR S     D++L +
Sbjct: 61  PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120

Query: 362 KSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
                  H ++        +       F ++ ++V HY S            L+ P
Sbjct: 121 SCDGKVEHYRIMYHASKLSI--DEEVYFENLMQLVEHYTSD----ADGLCTRLIKP 170


>UniRef50_Q7YZX2 Bruton's tyrosine kinase-like protein n=1 Tax=Suberites domuncula
           RepID=Q7YZX2_SUBDO
          Length = 700

 Score =  135 bits (340), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 46/257 (17%), Positives = 89/257 (34%), Gaps = 10/257 (3%)

Query: 162 PLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
           P+  TP      G    G   P P ++  P         Y Q          + +    +
Sbjct: 160 PIGSTPSAGPGGGRVPRGPLPPTPVQNLAPSPPPHGGTPYVQNSHGPSPNAPRGYESH-E 218

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
           +    P          +   P        P  P P      +   + G E+  L   + +
Sbjct: 219 LAAPAPSSGRSSYHGQTDQPPPPVPSRVRPPEPKPSDFDVIAMYDYPGLERGDLPLVKGQ 278

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL-C 340
           +  +         ++      E   P        + L+++ W+   +SRT AEN+L+   
Sbjct: 279 RVTVFDATREFWWRARDEQGSEGYIPSNYVKK--MGLDSEEWFFPQLSRTRAENILKGEG 336

Query: 341 KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           +E  ++VRNS + +N ++LS+       H  +   + +KY + +    F S+ E++ ++ 
Sbjct: 337 REGGFVVRNS-SRENMYTLSICHEGQVRHYHIKLDESNKYFISEKH-RFPSIKELIEYHK 394

Query: 401 SRKLPIKGAEHMSLLYP 417
                  G     L  P
Sbjct: 395 LNG----GGLVTRLRKP 407


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  135 bits (340), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 38/188 (20%), Positives = 73/188 (38%), Gaps = 13/188 (6%)

Query: 237 SSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKS 296
            S +   G   +S P+SPLP+  L  +   +       L   + +K ++  +  +    +
Sbjct: 32  QSCNPLIGFSQLSPPSSPLPDN-LVVAIYSYNPKHDGDLGFEKGDKLKIINKDDSEWYLA 90

Query: 297 AKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSK 354
               + +       +   +  +E + W+   ISR +A   L        S+LVR SET+ 
Sbjct: 91  ESLTTGQRGYIPYNFIAMS-TMETEAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTP 149

Query: 355 NDFSLSLKS----SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
             +SLS++       G  H ++       + +      F+S+ E+V HY+          
Sbjct: 150 GSYSLSMRDFDNNGDGVKHYRIRNMDNGGFYITTK-ISFNSLKELVQHYSRDS----DGL 204

Query: 411 HMSLLYPV 418
              L+ P 
Sbjct: 205 CTKLVKPC 212


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score =  135 bits (340), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 58/121 (47%), Positives = 83/121 (68%)

Query: 303  EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
            +      +  D  +PLE Q WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK
Sbjct: 1390 QGYVTAVDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLK 1449

Query: 363  SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
             ++GFMHM++ R +  +Y+LGQ S PF +VPE++ H+   +LP++GAEHM L+ PV  + 
Sbjct: 1450 GAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLIEPVIAQL 1509

Query: 423  L 423
            L
Sbjct: 1510 L 1510


>UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU33_DROPE
          Length = 1444

 Score =  135 bits (339), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 57/121 (47%), Positives = 84/121 (69%)

Query: 303  EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
            +      +  D ++PLE Q WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK
Sbjct: 1324 QGYVTAVDLIDVSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLK 1383

Query: 363  SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
             ++GFMHM++ R +  +Y+LGQ S PF +VP+++ H+   +LP++GAEHM L+ PV  + 
Sbjct: 1384 GAKGFMHMRIQRNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQL 1443

Query: 423  L 423
            L
Sbjct: 1444 L 1444


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  134 bits (336), Expect = 7e-30,   Method: Composition-based stats.
 Identities = 36/154 (23%), Positives = 65/154 (42%), Gaps = 10/154 (6%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F+      LS  R +  ++       N   A+    +   P        + ++   
Sbjct: 5   AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIP-----KNYIEMKPHP 59

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+ G I R  AE +L +   + ++L+R SE++  DFSLS+K      H K+ R    KY 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
           L      F+S+ E+V ++ S    +   + + L 
Sbjct: 120 LWV--VKFNSLNELVDYHRSTS--VSRNQQIFLR 149


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  134 bits (336), Expect = 7e-30,   Method: Composition-based stats.
 Identities = 36/154 (23%), Positives = 65/154 (42%), Gaps = 10/154 (6%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           +   F+      LS  R +  ++       N   A+    +   P        + ++   
Sbjct: 5   AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIP-----KNYIEMKPHP 59

Query: 323 WYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+ G I R  AE +L +   + ++L+R SE++  DFSLS+K      H K+ R    KY 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
           L      F+S+ E+V ++ S    +   + + L 
Sbjct: 120 LWV--VKFNSLNELVDYHRSTS--VSRNQQIFLR 149


>UniRef50_B4QMW5 GD12452 n=4 Tax=Drosophila RepID=B4QMW5_DROSI
          Length = 1421

 Score =  133 bits (335), Expect = 8e-30,   Method: Composition-based stats.
 Identities = 42/202 (20%), Positives = 68/202 (33%), Gaps = 2/202 (0%)

Query: 178 EGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDS 237
                       +P          D   E ++ +                        +S
Sbjct: 111 NEALLQSRPLPHIPAGSTAASLLADAA-ELQQHQQDSGGLGLQGSSLGGGHSSTTSVFES 169

Query: 238 SPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA 297
           +      + ++  P     +P L  +   F+   ++ LS  + E+ R+     +G    A
Sbjct: 170 AHRWTSKE-NLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEA 228

Query: 298 KPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDF 357
              S         +  P   LE   WYHG ISR  AE LL      S+LVR SE+S    
Sbjct: 229 HSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR 288

Query: 358 SLSLKSSQGFMHMKLSRTKEHK 379
           S+SL+      H ++S   + K
Sbjct: 289 SISLRYEGRVYHYRISEDPDGK 310


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score =  133 bits (335), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 37/208 (17%), Positives = 75/208 (36%), Gaps = 13/208 (6%)

Query: 223 IKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEK 282
             D           +  S      D   P    P      +   F+G     LS  + E 
Sbjct: 14  STDTNSSNATQPKPNISSNFQSKPDQPPPVPWRPPEMSYIALYAFQGRNDGDLSFEKGEV 73

Query: 283 GRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR--LC 340
            ++    S     ++   +         +  P   LE + W+ G+ +R++A   L+    
Sbjct: 74  LKVFD-QSGDWWVASSTRTNVQGYIPCNYVAPVNSLEVEGWFFGSCTRSEAIMRLQADNL 132

Query: 341 KEASYLVRNSETSKNDFSLSLKSSQ-----GFMHMKLSRTKEHK-YVLGQNSPPFSSVPE 394
            + ++LVR SET    ++L+++ +         + ++ +TK+            F++V +
Sbjct: 133 PKGTFLVRESETRPGTYALTVRETDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVID 192

Query: 395 IVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           +V  + S+     G     LL P   +T
Sbjct: 193 VVKFHTSQP----GGLCSKLLKPCPKQT 216


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score =  133 bits (334), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 57/301 (18%), Positives = 96/301 (31%), Gaps = 20/301 (6%)

Query: 131 VPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRL 190
             E   + E    Q++  +    +E A Q +   +   +        E E      E   
Sbjct: 129 DSELQSWKEEVARQEVARQEVARQEVARQEVARQEVARQEVARQEKREAEERRRAEEEVR 188

Query: 191 PEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISG 250
             + +R  E Y    E ++ER  + +   ++  K             S +    D     
Sbjct: 189 RVEQKRKQEIYMDLREVREERDDQHWQDSLRKSKAADLRRR------SIAKQTRDDHRRQ 242

Query: 251 PASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE 310
               L    +   +  F G         +     +            + LS      +  
Sbjct: 243 SVKALERGRVAAVTKAFGGDRPVLPPKPKPRNLTVTSDTLNPKQGLQRTLSTSSREHIIR 302

Query: 311 WTDPAL----------PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
           W                     W+HG ISR +AE+LL   +   +LVR SE     + LS
Sbjct: 303 WFQEEQLPFRAGFQKDQSRIASWFHGIISRQEAEDLLSEGEPGHFLVRVSERILG-YVLS 361

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            +    F H  +  T E  Y+L  +   F+S+ E+V  +    + + G E   LL P   
Sbjct: 362 YRCKDEFKHFLIDAT-EGCYMLLGHQIRFTSLAELVEFHKGEPITMSGGEQ--LLQPCGQ 418

Query: 421 R 421
           R
Sbjct: 419 R 419


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score =  133 bits (334), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 53/279 (18%), Positives = 90/279 (32%), Gaps = 9/279 (3%)

Query: 144 QKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQ 203
           Q +       +   +        P +    G   +    P P      +   +  + Y Q
Sbjct: 323 QSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGK-EQTYYQ 381

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
                           ++      +  P G+L  +P+        +    P   P+   S
Sbjct: 382 GRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSS 441

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
           +     P K        E       L     K+A    + P SP          L+ + W
Sbjct: 442 AES--SPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETW 499

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           Y G +SR +AE LL   K+  +LVR S T+   F L+   +    H+ L    E    + 
Sbjct: 500 YQGEMSRKEAEGLLE--KDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLV-DPEG--TIR 554

Query: 384 QNSPPFSSVPEIVHHYASRKLPI-KGAEHMSLLYPVAIR 421
                F S+  +++H+    LPI      + L  PV  +
Sbjct: 555 TKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593


>UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 domain containing adaptor
           protein B n=1 Tax=Ciona intestinalis RepID=UPI000180BDCA
          Length = 627

 Score =  133 bits (334), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 59/183 (32%), Positives = 95/183 (51%), Gaps = 2/183 (1%)

Query: 239 PSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSA- 297
                  R  S   S +P+ +    S  F+  +         +K  +P        +   
Sbjct: 441 NPHISHSRSRSYEISSVPQLNRHSKSHSFDNQDPGDDYEHPWDKPSIPKVHLESMQRFQH 500

Query: 298 KPLSMEPSSPLGE-WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND 356
           + L + PS  + +   DP LPL  Q WYHGAI+R +A   L      SYLVRNSE++ N+
Sbjct: 501 RQLELHPSEAIADKDFDPLLPLTKQGWYHGAITRDEANMRLSREVPGSYLVRNSESTANN 560

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           +SLSL++    +HM +S T++  ++LG+ S PF SVPE++  Y++ +L I   +++SL Y
Sbjct: 561 YSLSLRTRSTTIHMVISSTRDGFWILGEFSAPFHSVPEMIAFYSTHRLKINDTQNISLKY 620

Query: 417 PVA 419
           P+ 
Sbjct: 621 PIT 623


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  132 bits (332), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 46/209 (22%), Positives = 78/209 (37%), Gaps = 12/209 (5%)

Query: 216 FAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD-ISGPASPLPEPSLEDSSAQFEGPEKSC 274
             +  K  K LP  P   Q+  SP L       +S P  P+PE     +   F G E   
Sbjct: 152 QHLTPKEKKPLPPTPDQNQVMPSPQLHKNCPSALSRPLPPVPEFQQVVAKFDFPGIEAQD 211

Query: 275 LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE-WTDPALPLENQVWYHGAISRTDA 333
           L   +     +    +    ++      E   P    +      LE   W+   I+R  A
Sbjct: 212 LPLVKGCTYVILDDKNPHWWRAQDEEGREGLIPSTYVYPLTRFDLEQNRWFCKDITRAKA 271

Query: 334 ENLLRL-CKEASYLVRNSETSKNDFSLSLKS---SQGFMHMKLSRTKEHKYVLGQNSPPF 389
           E LLR    E S+LVR S +     ++S+ S    +   H  + +    ++ L +    F
Sbjct: 272 EQLLRQAGSEGSFLVRES-SQVGKLTVSVYSCIPCEVVKHYHVKQLPTGEWYLAEKH-TF 329

Query: 390 SSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           S++ +++H++              L +PV
Sbjct: 330 STISDLIHYHQHN----AAGLVTRLRHPV 354


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score =  132 bits (332), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 78/238 (32%), Positives = 114/238 (47%), Gaps = 12/238 (5%)

Query: 198  PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
             E  D P++  K R  +                 +  L             +        
Sbjct: 945  QELSDLPFDMPKLRRRRMLMQQDANTSGSATSVDLKDLPFDMPKLRRRLRCTQSTESSTS 1004

Query: 258  PSLEDSSAQFEGPEKS-----------CLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSS 306
             +    S +   P  +            L+       +L      G       L +  S 
Sbjct: 1005 QASSSLSVRDVDPPPALFGGGLARPKMTLNLDGGNGQQLLGLKKPGGLNLGLSLELTASR 1064

Query: 307  PLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQG 366
               +  D  LPLE Q WYHG+I+R +AE +LRL +E SYLVRNSE++K D+SLSLKS++G
Sbjct: 1065 GSADLVDVELPLERQGWYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARG 1124

Query: 367  FMHMKLSRTKE-HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            FMHM++ + +E + Y+LGQ S PF S+PE+V H++  +LPI+GAEHM LL+PV  + L
Sbjct: 1125 FMHMRIQKNEELNAYILGQFSKPFDSIPEMVRHFSINRLPIRGAEHMCLLHPVIAQLL 1182


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  132 bits (331), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 39/243 (16%), Positives = 84/243 (34%), Gaps = 12/243 (4%)

Query: 180 EGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSP 239
            G+         +   +  +E     + + ++  K     +K  +         +     
Sbjct: 38  RGSAKRVSLEQAQQALKDQDEKRMEKKKRHQQQRKEEQRLLKQQQKEEKQRIKEEKRRKG 97

Query: 240 SLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKP 299
                   +      +P  +   +   ++   KS L   + +   +       N   A+P
Sbjct: 98  PATPKQEPVK---CFIPINTKVTAVYDYQPKSKSELQLKQGDVFVITN-SENENWWEAQP 153

Query: 300 LSME--PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDF 357
           +            +      L+++ +YHG I RT AE  L      S+LVR S+++  + 
Sbjct: 154 VGNSDIVGWVPSNYVVKLNSLDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEH 213

Query: 358 SLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           ++SL+      H ++SRT +  ++       FS+V ++V  Y  +           L + 
Sbjct: 214 TISLRCDGKVFHYRISRTDKGVFIAAD--RVFSTVQDLVKFYHQQS----DGLVHPLRHA 267

Query: 418 VAI 420
           V  
Sbjct: 268 VPK 270


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score =  132 bits (330), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 45/319 (14%), Positives = 104/319 (32%), Gaps = 28/319 (8%)

Query: 111 PFDVQETGEGSAGASGAPEKVPENDGYMEP---YEAQKMMAEIRGSKETATQPLPLYDTP 167
           P         +     +P    E+ G +EP    +    +  I    +   +P    +T 
Sbjct: 9   PSVSNNAKIENTKKGDSPSTGSEDGGNIEPINDNDFDVFLENIPDDIQDIEEPDHTNNTT 68

Query: 168 YEPEEDGATAEGEGAPWPRESRLP----------EDDERPPEEYDQPW-------EWKKE 210
           +    +     G    +  E RL            + +R P  Y   +        ++  
Sbjct: 69  FSAPPENQWYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRIT 128

Query: 211 RISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQF-EG 269
            +   + +  +    L          S     +     + P  P+ +     +   + + 
Sbjct: 129 AVCGDYYIGGRQFNSLMDLVAYYTHCSDLLKKERLIHPTPPPEPVNDKKRIVAILPYTKM 188

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV----WYH 325
           P+   LS  + +   +   +  G        + E      E  D      +      W+H
Sbjct: 189 PDTDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGLIFRELVDDLDDSIDPNTVFSWFH 248

Query: 326 GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQN 385
             +++++A ++L      S+LVR S+ S  D+SL    +      ++ + K  +Y++G  
Sbjct: 249 PNVTKSEAVDMLVKAGPGSFLVRPSDNSPGDYSLFFHINNQIQRFRIEK-KGVRYLMG-- 305

Query: 386 SPPFSSVPEIVHHYASRKL 404
              F  +  +++ Y   ++
Sbjct: 306 GRTFECLDAVINRYRKEQI 324



 Score =  100 bits (248), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 7/99 (7%)

Query: 320 NQVWYHGAISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
              WYHG + R  AE  LR   +  SYLVR S+     + LS     G  H +++     
Sbjct: 74  ENQWYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRITAVCGD 133

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
            Y+       F+S+ ++V +Y      +K      L++P
Sbjct: 134 YYI---GGRQFNSLMDLVAYYTHCSDLLKKE---RLIHP 166


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  131 bits (329), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 56/334 (16%), Positives = 106/334 (31%), Gaps = 20/334 (5%)

Query: 98  EPRPLAILEDYADPFDVQETGEGSAGASGAPEKV----PENDGYMEPYEAQKMMAEIRGS 153
                  + D + P                  K+           E  E + +    +  
Sbjct: 114 SNLVPGTMADSSTPSRKGTAKRTKKEKGFVKLKIFFEQSSGHLVAEIREGRGLPKPCQPF 173

Query: 154 KETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPE-DDERPPEEYDQPWEWKKERI 212
            + A       +   + + D A  +     W    R P  + E   E+  +   W+K  +
Sbjct: 174 VKVAIA----SEKASKQKSDPAREKSTDPVWSTGFRWPLGNAEEYMEDVLELTLWEKGAL 229

Query: 213 SKAFAVD--IKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGP 270
              F       + + +  P P+    +      G            E  +  +    +  
Sbjct: 230 KDQFCGRMAFPIGELIENPDPLEGWFALLDADKGKSGYRKFEPDTSEGKVVVALYDNDPR 289

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPL-SMEPSSPLGEWTDPALPLENQVWYHGAIS 329
               LS  +++        S G     + L + E     G +  P   LE + W+ G I+
Sbjct: 290 GDMELSMRKDDYL--LELRSDGAWVQCRHLMTNEEGFVPGTFVAPYKSLEAEPWFFGPIT 347

Query: 330 RTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP 387
           R  AE LL     K   +L+R SE++   FSLS+K  +   H ++ +      + G  S 
Sbjct: 348 RAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGENVRHFRVKKVAGGIKLQGSPSS 407

Query: 388 PFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           P   +P ++ ++   +    G    +L  P    
Sbjct: 408 PHKDLPSLIKYHKRHR----GGLTTTLKVPCPRE 437


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score =  131 bits (329), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 32/199 (16%), Positives = 65/199 (32%), Gaps = 12/199 (6%)

Query: 230 PPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRL 289
             + QL+ +     G+    G      E     +   ++      LS  + +   L    
Sbjct: 45  GTISQLNGTSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLLDHS 104

Query: 290 SAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL--RLCKEASYLV 347
           +          + +       +      +E++ WY G I R  AE L+      + ++L+
Sbjct: 105 NCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLI 164

Query: 348 RNSETSKNDFSLSLKS------SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           R  E    +F+L+++            H K+ R    +         F S+ E+V +Y+ 
Sbjct: 165 REREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSD 224

Query: 402 RKLPIKGAEHMSLLYPVAI 420
                       L +P   
Sbjct: 225 VP----DGLCCQLTFPAPR 239


>UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS
          Length = 1495

 Score =  130 bits (327), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 57/121 (47%), Positives = 84/121 (69%)

Query: 303  EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
            +      +  D ++PLE Q WYHGAI+R +AE  LR   E S+LVRN E++K D+SLSLK
Sbjct: 1375 QGYVTAVDLIDVSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLK 1434

Query: 363  SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
             ++GFMHM++ R +  +Y+LGQ S PF +VP+++ H+   +LP++GAEHM L+ PV  + 
Sbjct: 1435 GAKGFMHMRIQRNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGAEHMCLIEPVIAQL 1494

Query: 423  L 423
            L
Sbjct: 1495 L 1495


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score =  130 bits (325), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 40/218 (18%), Positives = 76/218 (34%), Gaps = 13/218 (5%)

Query: 208 KKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQF 267
             E + + +    +                             P+    E     +   F
Sbjct: 34  TDEELPEKYTQHRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDF 93

Query: 268 EGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP-LENQVWYHG 326
              E   L+  R E+  +  + +    K+   L  E   P    T+  +  LE   WYH 
Sbjct: 94  LPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHR 153

Query: 327 AISRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSSQG-----FMHMKLSRTKEHKY 380
            I+R  AE+LLR   KE +++VR+S      +++S+            H ++ +    ++
Sbjct: 154 NITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARSTEAAIKHYQIKKNDSGQW 212

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
            + +    F S+PE++ ++              L YPV
Sbjct: 213 YVAERH-AFQSIPELIWYHQHN----AAGLMTRLRYPV 245


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  130 bits (325), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 61/340 (17%), Positives = 120/340 (35%), Gaps = 38/340 (11%)

Query: 90  IIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAE 149
              +++  E + L + +D+ DPF+   T              PEN+ Y    + Q   AE
Sbjct: 24  SADMQNSDEFQDLPVHDDF-DPFESY-TELPEETVDANLTAPPENEWYHGCLDRQS--AE 79

Query: 150 IRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKK 209
           +R +           D P       +  +          +   +             ++ 
Sbjct: 80  LRLNAA---------DKPGSYLVRESERKPGSYVLSYLGQRGIN------------HFRV 118

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
             +   F V  +  + LP         S+    +  +  + P  P+ +     ++  +  
Sbjct: 119 TAVCGDFYVGGRQFQTLPELIGYYTHISNILKNERLQYPAPPPEPVDDKKKVVATLPYNK 178

Query: 270 PEK-SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL----PLENQVWY 324
                 LS    E   +   L  G        S E    + +   P      P E +VW+
Sbjct: 179 VPDTDELSFSAGEVFVVHNELGGGWLWVTSQRSGESGIIVQDLVKPVEGEIDPNEGKVWF 238

Query: 325 HGAISRTDA-ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           HG +S+ +A E L +      +L+RNS+ +  D+SLS +        ++ + ++ +YV+G
Sbjct: 239 HGNVSKEEAAETLWKDGDIGGFLIRNSDKNPGDYSLSFRGPNTIQRFRIQK-QQRQYVMG 297

Query: 384 QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                ++S+  IV HY   ++     +   L  P A +  
Sbjct: 298 --GRYYNSLDAIVDHYKKEEII----DGFKLRDPTAPKKF 331


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  129 bits (324), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 42/262 (16%), Positives = 78/262 (29%), Gaps = 27/262 (10%)

Query: 174 GATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVG 233
             +++      P   R PE D        +        +S + +        +P      
Sbjct: 137 SESSKTTLGCKPTTPREPEVDSAAARATVRTQPSSTSLMSLSSSGSPPSSSPVPQSSATS 196

Query: 234 QLDSSPSLPDGDRDISGPASPL------------------PEPSLEDSSAQFEGPEKSCL 275
           +  S           +  A P                    +                 L
Sbjct: 197 RHTSVREGSQDGSPPAFTAIPTGNAPPLSLPPRSPAPPPAQKMLEVRVMYSHNATTPGDL 256

Query: 276 SPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN 335
           S    +K  +    S  N   A+            +   A  +E++ W+HG ISR +A  
Sbjct: 257 SITEGDKLWVID-QSEPNWWKARDSQGRVGYIPSNYVRQA-GIESEAWFHGRISRAEAAA 314

Query: 336 LLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
           LL    +E  +LVR SE+   ++SLS+       H  + +  E  Y+   +   F  + +
Sbjct: 315 LLHVAKQEGCFLVRESESKVGEYSLSVSHGDSLRHYHIKKEGEEFYI--NDRHRFPDICK 372

Query: 395 IVHHYASRKLPIKGAEHMSLLY 416
           ++ ++        G     L  
Sbjct: 373 LIEYHKLNS----GGLVTRLRK 390


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score =  129 bits (324), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 46/245 (18%), Positives = 82/245 (33%), Gaps = 14/245 (5%)

Query: 167 PYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDL 226
           P + +       G     P  +    +    P + D   +  K++   + AV   +    
Sbjct: 29  PLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQGDPRQQGLKDKACGSLAVGFHLSPTY 88

Query: 227 PWPPPVGQLDSSPSLPDGDRDISGPASPLP---EPSLEDSSAQFEGPEKSCLSPGREEKG 283
             P           +  G   I    S +P     +L  +   +E      L   + E+ 
Sbjct: 89  FLPGL--AFLVPHPVTPGFLPIPARFSLMPLVFTDNLVIALHSYEPSHDGDLGFEKGEQL 146

Query: 284 RLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR--LCK 341
           R+    S    K+    + +       +   A  LE + W+   +SR DAE  L      
Sbjct: 147 RILE-QSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNT 205

Query: 342 EASYLVRNSETSKNDFSLSLKSSQG-----FMHMKLSRTKEHKYVLGQNSPPFSSVPEIV 396
             S+L+R SE++   FSLS++           H K+       + +      F  + E+V
Sbjct: 206 HGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYIS-PRITFPGLHELV 264

Query: 397 HHYAS 401
            HY  
Sbjct: 265 RHYTR 269


>UniRef50_Q6GP30 MGC80721 protein n=2 Tax=Xenopus RepID=Q6GP30_XENLA
          Length = 508

 Score =  129 bits (323), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 74/420 (17%), Positives = 116/420 (27%), Gaps = 68/420 (16%)

Query: 58  AHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQET 117
             R  I   PQ     P+ K+ S+  S          D   P      +DY  P    E 
Sbjct: 83  QKRAAIPRIPQETEFIPEDKEFSDSDSFE-------EDYESPNEFDDDDDYERPASENED 135

Query: 118 GEGSAGASGAP-------------EKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLY 164
            +G+      P             +    N  Y +      M       K       P  
Sbjct: 136 EDGNGDYEPPPPNIEDTHPAICQIKPNATNSPYADREFGNSMKNPPEPPKRPGNPAPPTN 195

Query: 165 ----DTPYEPEEDGATAEGEGAPWPRESRLPE-DDERPPEEYD----------QPWEWKK 209
                  Y P  +         P       P  +   PP               P +   
Sbjct: 196 RGHTFPGYSPSSNQENRSNTLGPSIDRRTKPSFEINCPPNVGRGIGAQGKKPFIPGKILP 255

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
                   V  K+   +  P P  + +            S P      P  + S  QF  
Sbjct: 256 GHAGIGQQVPEKLPNLIKPPIPSERNNQPFERKIPSPRPSLPMEKRFNPEEDASLRQFPS 315

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKP--------------------------LSME 303
           P     S               G P +  P                              
Sbjct: 316 PGGPGFSSNTFPPRPSAKNSFPGLPVTDGPGLPGPAPPPHKPGNMNRSFSEGTCNGRPPA 375

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNS--ETSKNDFSLS 360
           P       T     L    WY G ISR++AE  LR   ++ ++LVRNS   T+ + + L 
Sbjct: 376 PIPTNYNQTTEKESLSQDQWYTGNISRSEAETALRSINQDGTFLVRNSSKSTASHPYVLM 435

Query: 361 LKSSQGFMHMKLSRTK-EHKYVLG---QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
           +       ++++ + +  + Y+LG   +    F+SV EI+ ++    L +   +  SL  
Sbjct: 436 VLYRNKVYNIQIRQDQTNNVYMLGSGLRGQETFASVMEIIDYFHKTPLLLIDGKDQSLRQ 495


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  129 bits (323), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 34/171 (19%), Positives = 64/171 (37%), Gaps = 8/171 (4%)

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKP-LSMEPSSPLGEWTDP 314
           P      +           +     +      +  +      +  ++         +   
Sbjct: 169 PAVDTFVALYDHTPGCAKEMLLRAGDMLLRVNKDPSKEWTLVENCVTGCQGFVPTSFIAA 228

Query: 315 ALPLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           +  LE+  W+ G I+R+ AE  L    C   S+L+R SE+S   +SLSL+      H ++
Sbjct: 229 SASLESHAWFFGKIARSKAEKFLNDPRCHHGSFLIRESESSPGQYSLSLRDGDTVRHYRV 288

Query: 373 SRTKEHKYVL-GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
              +   Y L G  +  F+S+PE++  +  RK  +  A    L  P    +
Sbjct: 289 ENYEGGLYKLQGSPTQKFASLPELIAFHGQRKAGLATA----LREPCPKES 335


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  128 bits (322), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 30/207 (14%), Positives = 70/207 (33%), Gaps = 11/207 (5%)

Query: 212 ISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPE 271
           I          + D        +  +    P      + P  P        +   +    
Sbjct: 151 IEPQIDTSTAPVADTQTTTAKAEPRAEEEAPPRPPKSAAP--PEVVLFEVTALFNYNATN 208

Query: 272 KSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
              L   + E   +         + A+  + +       +       E++ WY G +SR 
Sbjct: 209 PDDLDLKQGETLEVLSTEEEFWWR-ARNSAGKVGMIPSNYVAKP-GFESEPWYVGKMSRV 266

Query: 332 DAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFS 390
           +A++ L++   + ++LVR SETS   ++LS+  +    + ++       Y+  ++     
Sbjct: 267 EAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYRIQHDGNEYYITTRHRQK-- 324

Query: 391 SVPEIVHHYASRKLPIKGAEHMSLLYP 417
           ++ E++ ++        G     L  P
Sbjct: 325 TIKELIDYHKLNG----GGLCTRLKKP 347


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score =  128 bits (321), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 32/205 (15%), Positives = 69/205 (33%), Gaps = 12/205 (5%)

Query: 223 IKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEK 282
             D     P+             R        +    +  +   ++  ++S LS  + ++
Sbjct: 62  TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDR 121

Query: 283 GRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE 342
             +     +   +     + +       +      + ++ W+   + R +A+ LL   + 
Sbjct: 122 MEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEEN 181

Query: 343 --ASYLVRNSETSKNDFSLSLK-SSQG----FMHMKLSRTKEHKYVLGQNSPPFSSVPEI 395
              ++LVR SE + N +SLS+K    G      H ++       Y +  N   F S+  +
Sbjct: 182 PRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQ-TFPSLQAL 240

Query: 396 VHHYASRKLPIKGAEHMSLLYPVAI 420
           V  Y+   L +       L  P   
Sbjct: 241 VMAYSKNALGL----CHILSRPCPK 261


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  128 bits (321), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 37/158 (23%), Positives = 64/158 (40%), Gaps = 10/158 (6%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
               +   F+  E   L+  + +  ++       N   A+   +E   P        + +
Sbjct: 1   MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIP-----KNYIRV 55

Query: 319 ENQVWYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           +   WY G ISR  AE +L       ++L+R SE+S  +FS+S+       H K+ R   
Sbjct: 56  KPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREAS 115

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
            KY L +    F+S+ E+V  Y +    I     + L 
Sbjct: 116 GKYFLWEE--KFNSLNELVDFYRTT--TIAKKRQIFLR 149


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  128 bits (321), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 35/194 (18%), Positives = 60/194 (30%), Gaps = 41/194 (21%)

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK------------------PLSMEPS 305
              F G     L   + ++  +       N   A+                  P++    
Sbjct: 14  KYNFPGSSPHDLPFKKGDRLVIVAPSKDPNWYKARREDGLEGMIPFNYVQEKVPVAGSAP 73

Query: 306 SPLGEWTDPALP------------------LENQVWYHGAISRTDAENLLRLCKEASYLV 347
            P       A                    L+   W+HG ISR DAE LL   K   +LV
Sbjct: 74  QPPQRPVLSAPQPVADNDAAMNHASKGAVQLKTMPWFHGRISREDAEKLLTPPKNGRFLV 133

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           R S+    D++L +       + ++ R ++    +  +   F ++ ++V HY        
Sbjct: 134 RESQNYPGDYTLCVSYDGRVENYRVRRNEKGLVTV-DDDEYFDNLIKLVEHYQKE----A 188

Query: 408 GAEHMSLLYPVAIR 421
                 L  PV   
Sbjct: 189 DGLCTRLKAPVDKE 202


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  128 bits (320), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 40/215 (18%), Positives = 83/215 (38%), Gaps = 17/215 (7%)

Query: 214 KAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKS 273
           K  +   K  K LP  P   Q+   P  P+        +    E     +   +     +
Sbjct: 176 KPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTS----ELKKVVALYDYMPMNAN 231

Query: 274 CLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDA 333
            L   + ++  +    +    ++      E   P    T+    +E   WY   ++R+ A
Sbjct: 232 DLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQA 291

Query: 334 ENLL-RLCKEASYLVRNSETSKNDFSLSLKS------SQGFMHMKLSRTKEHKYVLGQNS 386
           E LL +  KE  ++VR+S +    +++S+ +           H  +  T + +Y L +  
Sbjct: 292 EQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKH 350

Query: 387 PPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
             FS++PE+++++      +       L YPV+ +
Sbjct: 351 L-FSTIPELINYHQHNSAGLIS----RLKYPVSQQ 380


>UniRef50_UPI000069FBD6 Tensin-like C1 domain-containing phosphatase (EC 3.1.3.-) (C1 domain-
            containing phosphatase and tensin homolog) (C1-TEN)
            (Tensin-2). n=2 Tax=Xenopus (Silurana) tropicalis
            RepID=UPI000069FBD6
          Length = 1664

 Score =  128 bits (320), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 61/400 (15%), Positives = 115/400 (28%), Gaps = 38/400 (9%)

Query: 39   SSAQPHSWMLTPSPLNSHCAHREPISS---SPQPVANGPKQKKKSNWRSTTRLRIIRLRD 95
            +S + H+  L   P   +C  R+  +S   SP        Q   +   + T     + + 
Sbjct: 1119 TSKEVHNTALPSEPQTGNCVARQITNSYPHSPNHTHISEDQTPVTTAFALTETDRPQQKM 1178

Query: 96   RLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKE 155
                  +++      P+    T    A    AP    E +  +    +Q  + +      
Sbjct: 1179 VQSHSSVSVNNSSVKPYSTVHTPGLPATHVNAPPCANEANTLLPTSSSQSHVTKFVLPVT 1238

Query: 156  TATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKA 215
            +         T + P    ++      P       P+  E P      P   + + +  +
Sbjct: 1239 S---EAKRSHTTFGPAISSSSGTTAFGPV-----NPQGKEAPTSPPKSPMGSQSDLLPPS 1290

Query: 216  FAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCL 275
                  +        P       P LP+ +   +  A   P    E +         S  
Sbjct: 1291 PTPSFPIRTAYYSSSPCPPSIQPPRLPEKNHSPADGAKVDPNGLSECNKGHSSPVGWSKS 1350

Query: 276  SPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN 335
            +  R         L             +         D +       WY   ISR  A  
Sbjct: 1351 ALCRGMLEEYSKHLQYFFLHFYSDTQQDVPVTGNFVQDSSK-----FWYKPTISREQAIA 1405

Query: 336  LLRLCKEASYLVRNSETSKNDFSLSLK-----------------SSQGFMHMKLSRTKEH 378
            +LR  +  S+L+R+S + +  + L+LK                 + Q   H  +    + 
Sbjct: 1406 ILRGAEPGSFLIRDSNSFRGAYGLALKVASPPPNVAAQPYKGDSTEQLVRHFLIETGPKG 1465

Query: 379  KYVLGQN-SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
              + G    P F S+  +V  ++   L +       L  P
Sbjct: 1466 VKIKGSPIEPHFGSLSALVSQHSVTPLSL----PCRLQIP 1501


>UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T185_NEMVE
          Length = 983

 Score =  128 bits (320), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 39/213 (18%), Positives = 80/213 (37%), Gaps = 8/213 (3%)

Query: 209 KERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFE 268
           K    +      K    +    P   +  +   P+  R +S P     +  +  +   F 
Sbjct: 543 KCPECRGNRRPNKSFTGVSPFMPRSPISLASISPERQRKVSAPPRMGTDAQVVVAIQNFH 602

Query: 269 G---PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW-Y 324
           G     +S L+    ++G      + G       ++   ++  G   +  L +      +
Sbjct: 603 GIAPSGRSSLNMVIGDEGLSIRTGTTG-YFPRSHVTSTENADAGNKQNQGLSIRTGTTGF 661

Query: 325 HGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQ 384
            G + RT+AE       + ++LVR S     +++LS++      H+K+   ++  + L Q
Sbjct: 662 AGKMDRTEAEQETMGRSDGTFLVRESANRAGEYALSVRFRNATKHIKIPY-EDGTFCLTQ 720

Query: 385 NSPPFSSVPEIVHHYASRKLPIK-GAEHMSLLY 416
            S  F S+PE+V +Y    L +       +L  
Sbjct: 721 -SKVFDSIPELVAYYRENTLGVSFTGLDTTLRC 752


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  127 bits (318), Expect = 9e-28,   Method: Composition-based stats.
 Identities = 42/215 (19%), Positives = 73/215 (33%), Gaps = 18/215 (8%)

Query: 208 KKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP---------EP 258
           KK ++       +    +   P    Q              S  A  LP         + 
Sbjct: 4   KKSKLDGDQNGCVLEPVNKEHPVRTDQTYVRDPTSYKPPITSQNAGLLPGQVFQKMEEKE 63

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
            +  +   +E      L   + EK ++         K+    + +       +   A  +
Sbjct: 64  KIVVALYPYEAIHADDLGFKKGEKLKIIEEHG-EWWKARSLTTRKEGFIPSNYVAEADTM 122

Query: 319 ENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKS-----SQGFMHMK 371
           E + W++  I+R DAE  L     K  SYL+R SETSK  +SLS++           H K
Sbjct: 123 ETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDVVKHYK 182

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           +       Y +      FS +  ++ HY  +   +
Sbjct: 183 IRSLDNGGYYIS-PKITFSDISSMIKHYHKQSDGL 216


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score =  127 bits (318), Expect = 9e-28,   Method: Composition-based stats.
 Identities = 48/253 (18%), Positives = 85/253 (33%), Gaps = 29/253 (11%)

Query: 188 SRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPP-------PVGQLDSSPS 240
           +  P DD  P           K R+S+ F     +++ +   P       P   L  SPS
Sbjct: 34  ASRPMDDVSPFLPSRS--LSSKARVSETFQNSPPLVRCVKSKPQSCQPTNPTSNLAISPS 91

Query: 241 LPDGDR-----DISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
            P   +      ISG +    +P    +   +    +      R ++  L     +    
Sbjct: 92  HPSETQTVTTSKISGRSVKQLKPKHYVALFDYNARTEEETFLSRRDEVLLLADTDSEWWL 151

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETS 353
                S         +      +E + W+   +SR D+E LL L       +LVR SETS
Sbjct: 152 VQNLSSGRKGYVPSSFVAKKGSVEAEEWFMPMLSRKDSERLLLLEGNAQGVFLVRESETS 211

Query: 354 KNDFSLSLKSSQG--------FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP 405
           +   +LS++  +           H ++    +++Y        FSS+ E++  Y+     
Sbjct: 212 QGSLTLSVRDEERGLSGIMNTVKHYRIKH-PDYRYYYITTKCSFSSLQELIQFYSIDS-- 268

Query: 406 IKGAEHMSLLYPV 418
                   L    
Sbjct: 269 --HGLCCKLTRAC 279


>UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=1 Tax=Tribolium castaneum
           RepID=UPI0001757DDC
          Length = 952

 Score =  127 bits (317), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 43/223 (19%), Positives = 85/223 (38%), Gaps = 11/223 (4%)

Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
           PE +    ++    + +   ++       P    +  L      P  +R I    +    
Sbjct: 431 PENHRSTLKFVMAHLCRMCQMEYSRGNHSPPTVLIQALCHIFLRPPWERIIQVVYNTQSH 490

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
             + +                      +PPR + G  +      +  +S L +    A  
Sbjct: 491 NRILEVLLLKCSWGVKLPEFA--SAPAIPPRRAVGTAR------ISTNSTLDKEKSNAFS 542

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L+   WY G I R +    L+   + ++LVR++ T   +++L+L+       +K+   K 
Sbjct: 543 LQEAEWYWGDIKREEVNEKLKETPDGTFLVRDASTKSGEYTLTLRKGGTNKLIKICH-KN 601

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVA 419
            KY   +    F+SV E+++H+ +  L    A   + LLYPV+
Sbjct: 602 GKYGFTEPY-TFNSVVELINHFRNESLSQYNASLDIKLLYPVS 643



 Score = 82.0 bits (200), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 35/218 (16%), Positives = 75/218 (34%), Gaps = 7/218 (3%)

Query: 206 EWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSA 265
             + ++ ++   +    + +      +  +  S    D   +     +   E  L     
Sbjct: 716 HAQVKKEAQPHEIVGLTVNEKLLTQRLKMMQESSEHLDKTLEEKEAYNRTLERELTALKP 775

Query: 266 QFEGPEKSCLSPGREEKGRLPPRLSAGN--PKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
                 K      R  + R            ++++       S      D  +  + + W
Sbjct: 776 VVHSLRKERDKYIRWLQERGVSPTKINQVLNRNSEDEEYNTQSGEECDVDSLIHNDERTW 835

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
                 R DAE  L    + ++L+R S TSK  ++LS+  ++   H  +  TK       
Sbjct: 836 LMLDCRRIDAEKYLAGQPDGTFLIRTSSTSK--YALSIACNKMVNHCIIHDTKRGXXXXX 893

Query: 384 QNSPP--FSSVPEIVHHYASRKLPIKG-AEHMSLLYPV 418
              P   + ++ ++V HYA+  L I   + +  L +P+
Sbjct: 894 XXXPYNIYPTLKDLVLHYATNSLEIHNDSLNTVLAHPL 931


>UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=1 Tax=Macaca mulatta RepID=UPI0000D9EE2E
          Length = 221

 Score =  126 bits (316), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 76/219 (34%), Positives = 103/219 (47%), Gaps = 3/219 (1%)

Query: 207 WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQ 266
           + K          + V                            P               
Sbjct: 2   YTKSGDDYDENKAVPVPHQPASVILSSGAVILHLRSPPSTPPGLPGCRSTSEGWGGGVMG 61

Query: 267 FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV---W 323
                  C      ++ R P  ++ G P+         + P      P   L       W
Sbjct: 62  SPSAGAHCHPSLGLQEKRGPRCVNLGLPEPVSLSGNGMTPPTRSTNTPGDTLCCCPIYGW 121

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           +HG ++R DAE+LL LCKE SYLVR SETS  D SLSL+SSQGF+H+K +RT+E++ VLG
Sbjct: 122 FHGPLNRADAESLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQVVLG 181

Query: 384 QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
           Q+S PF SVPE+V HY+SR LP++GAEH++LLYPV  +T
Sbjct: 182 QHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQT 220


>UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=5 Tax=Eutheria
           RepID=B0R097_MOUSE
          Length = 161

 Score =  126 bits (316), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 97/158 (61%), Positives = 104/158 (65%)

Query: 255 LPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDP 314
            PE        +   PE     P   ++     +       +    +    +       P
Sbjct: 4   SPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAGDTQNGWAWTARDPAEMP 63

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
             P     WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR
Sbjct: 64  PFPSLILSWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 123

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM
Sbjct: 124 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 161



 Score = 53.9 bits (127), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 42/49 (85%), Positives = 45/49 (91%)

Query: 173 DGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIK 221
           +GA+ EGEG PWPRESRLPEDDERPPEEYDQPWEWKKERISKAFA D +
Sbjct: 1   EGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAGDTQ 49


>UniRef50_Q70DV1 Src tyrosine kinase n=3 Tax=Schistosoma mansoni RepID=Q70DV1_SCHMA
          Length = 647

 Score =  126 bits (316), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 36/217 (16%), Positives = 71/217 (32%), Gaps = 13/217 (5%)

Query: 213 SKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK 272
           S       +     P   P   L++S +    +   + P   +P      +   +     
Sbjct: 114 SSCLPNTHQSTNFSPTQQPANFLNNSVAHMRNNPSHNSPQ--IPTEGQFVALHDYVKRVD 171

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
             L+  + +   +          +    +                LE+  WY G + R +
Sbjct: 172 DDLNMTKGQIFNILDNSHCDWWYAECVSTGNRGYVPKNHLAAVTSLESNEWYFGELKRIE 231

Query: 333 AENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL-----SRTKEHKYVLGQN 385
           AE+ L+       S+LVR SE+  +++SLS++      H ++           K      
Sbjct: 232 AEHYLQLPGNDHGSFLVRISESQSSEYSLSVREENTVKHYRIRSRYSRTDPTLKRFYISR 291

Query: 386 SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
             PF ++ ++V+HY   +          L  P    T
Sbjct: 292 QLPFVNIQQLVNHYLENQ----SGLCCRLGKPCIRPT 324


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  126 bits (315), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 37/161 (22%), Positives = 66/161 (40%), Gaps = 9/161 (5%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT-DPALPLENQ 321
           +   F+      LS    +K  +  R       + K +    ++    +       +E+Q
Sbjct: 73  ALWDFKARNDQELSFKAGDKFEITDRSGDWWTANKKDIFGRVTTGFVPYNYLARDSVESQ 132

Query: 322 VWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
            W+ G ++R  A + L   +    S+LVR SE+    + LS+++ +   H K+ +T +  
Sbjct: 133 PWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQTGDQF 192

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           YV       FSS+ E++ HY S  L I       L  P   
Sbjct: 193 YVDALF--KFSSIVEVIEHYQSHPLSIGD----LLSEPCIR 227


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  126 bits (315), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 43/184 (23%), Positives = 69/184 (37%), Gaps = 18/184 (9%)

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLS---------- 301
              L +          E   ++ LS  +  + R+           AK LS          
Sbjct: 3   TPNLTDEEFFVVLYPIESAGRNQLSLRKGCQLRVLRYNGTEEWCEAKVLSTGDPSDNAKC 62

Query: 302 ---MEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
                       +  PA  L    WYHGA+SR  AE LL      S+LVR+SE+ +   S
Sbjct: 63  AVVGSVGWVPSNYITPATSLNMHTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGHLS 122

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +S++ +    H +++      + +      F ++PE+VHH++             L YP 
Sbjct: 123 VSVRFNASVYHYRINVDTAGLFYISPEH-RFQTLPELVHHHSYAS----DGLAAILHYPA 177

Query: 419 AIRT 422
           A  T
Sbjct: 178 AKST 181


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  126 bits (315), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 50/240 (20%), Positives = 91/240 (37%), Gaps = 14/240 (5%)

Query: 182 APWPRESRLPEDDERPPEEY-DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
            P P+E     D     ++Y D   E ++ R  +A       + D+       + +    
Sbjct: 74  PPSPKEEGAILDLLSKQKQYRDASREIQELRCQEAKLSTQYSMLDVKLSEMGDEDNLPLG 133

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           +   +   +G  S     S   +S+     E+         K     ++ AG+  S +P 
Sbjct: 134 IIFPEGGGTGTLSTRTIQSPNLNSSTDSTTEQKSKRSNMANKMTKIFKVRAGHDSSHEPS 193

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
           + +P+          L LE + +YHGA+ R + E LL    +  ++VR    +   + LS
Sbjct: 194 NNQPTE---------LRLEEEEFYHGALPRKETEALL--VNDGDFVVREKSDAWGRYVLS 242

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            K +    H  +    E+ Y L      F +V E++    + + P+  A    LL PV  
Sbjct: 243 AKHASKVRHFPIQINDENMYRL--EGDAFQTVGELIRFQLNSRQPVTKASQAILLKPVCR 300


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  125 bits (314), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 41/220 (18%), Positives = 73/220 (33%), Gaps = 18/220 (8%)

Query: 211 RISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGP 270
           +   +     +    L     +   +    +P      S          L  +   F+  
Sbjct: 297 QPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAI 356

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDP--ALPLENQVWYHGAI 328
           E   LS  +  +  +         K  K            +  P   L LE   WY G +
Sbjct: 357 EGGDLSLEKNAEYEVIDDSQEHWWKV-KDALGNVGYIPSNYVKPKALLGLERYEWYVGDM 415

Query: 329 SRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKS---SQGFMHMKLSRTKEHKYVLGQ 384
           SR  AE+LL+   KE  ++VR S T K  ++LSL +        H  + +    +Y L +
Sbjct: 416 SRQRAESLLKQGDKEGCFVVRKSST-KGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE 474

Query: 385 NSPPFSSVPEIVHHYASRKLPIKGAEHMSLL-----YPVA 419
                 ++P++++++        G     L       PV 
Sbjct: 475 KHCC-ETIPDLINYHRHNS----GGLACRLKSSPCDRPVP 509


>UniRef50_Q63HR2 Tensin-like C1 domain-containing phosphatase n=29 Tax=Euteleostomi
            RepID=TENC1_HUMAN
          Length = 1409

 Score =  125 bits (314), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 85/428 (19%), Positives = 130/428 (30%), Gaps = 65/428 (15%)

Query: 20   GSRQGSPGHRKRASPKGSLSSAQPHSWMLTPS--------PLNSHCAHREPISSSPQPVA 71
            G R   PGH   A P  S  S +P SW   PS        P ++ C+    +S    P+ 
Sbjct: 854  GDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLH 913

Query: 72   -NGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEK 130
             + P Q K+S  R  TR        RL P         A P   Q     +         
Sbjct: 914  TSSPVQGKESTRRQDTRSPTSAPTQRLSPGE-------ALPPVSQAGTGKAPELPSGSGP 966

Query: 131  VPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRL 190
             P                           P    D P E    G  ++G     P  + L
Sbjct: 967  EP----------------LAPSPVSPTFPPSSPSDWPQE-RSPGGHSDGASPRSPVPTTL 1009

Query: 191  PEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISG 250
            P     P +    P        S   +    V   +PW     +   S   P      S 
Sbjct: 1010 PGLRHAPWQGPRGP------PDSPDGSPLTPVPSQMPWLVASPEPPQSSPTPAFPLAASY 1063

Query: 251  PASPLPEPSLEDSSAQFEGPEKSCLSPGREE---KGRLPPRLSAGNPKSAKPLSMEPSSP 307
              + L +P L        GP +     G E+     R         P  +  +   P  P
Sbjct: 1064 DTNGLSQPPL-PEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAPLLSDNVPQTPEPP 1122

Query: 308  LGEWTDPALPLEN--QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK--- 362
              E       +++  + WY   +SR  A  LL+     ++L+R+S + +  + L+LK   
Sbjct: 1123 TQESQSNVKFVQDTSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVAT 1182

Query: 363  ------------SSQGFMHMKLSRTKEHKYVLGQNSPP-FSSVPEIVHHYASRKLPIKGA 409
                          Q   H  +    +   + G  S P F S+  +V  ++   + +   
Sbjct: 1183 PPPSAQPWKGDPVEQLVRHFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISL--- 1239

Query: 410  EHMSLLYP 417
                L  P
Sbjct: 1240 -PCCLRIP 1246


>UniRef50_UPI0001925EBD PREDICTED: similar to protein tyrosine kinase n=3 Tax=Hydra
           magnipapillata RepID=UPI0001925EBD
          Length = 730

 Score =  125 bits (314), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 37/174 (21%), Positives = 68/174 (39%), Gaps = 7/174 (4%)

Query: 251 PASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGE 310
               L + ++  +   F    ++ LS    E+  L         K    L+ +       
Sbjct: 28  QKQCLSQENIYVALFNFTSNNEAELSFSCGEQLELLSISDGSWWKVRSLLTNKIGYIPNN 87

Query: 311 WTDPALPLENQVWYHGAISRTDAE-NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           + +    L+   WY G + R+ A   LL      S+LVR S +   D++LSL +     H
Sbjct: 88  YVEKYDYLKKYDWYTGVMGRSSANLALLSNGSAGSFLVRKSTSKPGDYTLSLHNETSLKH 147

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
             + +TK   + + +    FS++P +V HY      + G    +L    + + L
Sbjct: 148 YHIKKTKNCTFYILKEE--FSNLPSLVEHYKK----VSGGLPRTLKDACSQKKL 195


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  125 bits (313), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 45/202 (22%), Positives = 79/202 (39%), Gaps = 7/202 (3%)

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
           +          V QL  + +     +++        +         +E   +S  S  R+
Sbjct: 356 QKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERK 415

Query: 281 EKGRLPPR-LSAGNPKSAKPLSMEPSSPLGEWTDPAL-PLENQVWYHGAISRTDAENLLR 338
           E+         +       P S   SS L +    +  PL  Q WYHGAI R +A+ LL+
Sbjct: 416 ERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLK 475

Query: 339 LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHH 398
             K+  +LVR S     ++ LS+ S     H  +    ++ Y        FS++P+++ H
Sbjct: 476 --KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYV-DNMYRF--EGTGFSNIPQLIDH 530

Query: 399 YASRKLPIKGAEHMSLLYPVAI 420
           + + K  I     + LL P+  
Sbjct: 531 HYTTKQVITKKSGVVLLNPIPK 552


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  125 bits (312), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 10/171 (5%)

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLS---MEPSSPLGEWTDP 314
            S+  +   F+  +   LS    +  R+  R            S   ++     G +  P
Sbjct: 1   GSIYRALWAFQSQQGEHLSFREGDLFRVLSRRDDWWSVRRIDASGRVLDSGLVPGNYLAP 60

Query: 315 ALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           A   + Q W+ G ++R  A++ L      E ++L+R SE     + LS++S     H K+
Sbjct: 61  AESGQTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKV 120

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            +T ++++ + +    FSS+ E+V +Y    L   G     L  P    TL
Sbjct: 121 LQTDQNRFYV-EPGRRFSSLAELVDYYQKTSLNNAGP----LGNPCKRNTL 166



 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 27/102 (26%), Positives = 51/102 (50%), Gaps = 7/102 (6%)

Query: 322 VWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
            WY+G I+R  AE LL     K+ S+LVR SE+  +++++S +S     H ++ R+    
Sbjct: 249 PWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGA 308

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           Y +      F+++ E++ +Y      +     + L  P A +
Sbjct: 309 YFVSDR-ISFATLGELISYYQRNNRSL----GVLLEEPCAQQ 345



 Score = 99.3 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 46/259 (17%), Positives = 75/259 (28%), Gaps = 16/259 (6%)

Query: 166 TPYEPE-EDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIK 224
            PYE   + GA      +      R  +     P     P         +    D  ++ 
Sbjct: 568 MPYEGRNQPGAGWNSRRSRSLPVCRKEQQGGSGPAGVRVPAAVSHSLPPEHLPHDDGLLG 627

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
                    Q    P           P            +    G      +  +     
Sbjct: 628 GRAL-----QEALLPRPAQPAGRHLRPHLLQDHRVPAGGAPVLPGGGPVSGAEPQGRLVV 682

Query: 285 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
                        +P S E   P G   D A+   +     G       EN      E +
Sbjct: 683 GAEDRRQRPRPGQRPGSGELPGPGGVRPDAAMVFRDAEPPSGPEPPVAPEN-----SEGA 737

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +L+R SE     + LS++S     H K+ +T ++++ + +    FSS+ E+V +Y    L
Sbjct: 738 FLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYV-EPGRRFSSLAELVDYYQKTSL 796

Query: 405 PIKGAEHMSLLYPVAIRTL 423
              G     L  P    TL
Sbjct: 797 NNAGP----LGNPCKRNTL 811


>UniRef50_UPI0000F2151D PREDICTED: similar to SH2B adapter protein 3 (Lymphocyte-specific
           adapter protein Lnk) (Signal transduction protein Lnk)
           (Lymphocyte adapter protein) n=2 Tax=Danio rerio
           RepID=UPI0000F2151D
          Length = 596

 Score =  124 bits (311), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 51/400 (12%), Positives = 108/400 (27%), Gaps = 28/400 (7%)

Query: 29  RKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREP---ISSSPQPVANGPKQKKKSNWRST 85
            + + P  +  +                  +        S          + ++S  R  
Sbjct: 139 LRCSPPDTTHRTRNHSQENERSDFRTGSEGYSPTACDFPSRNDVTHISVSRIRESVCRLF 198

Query: 86  TRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQK 145
            +           PR   I      P    E    S        +  +     E +   +
Sbjct: 199 KKSPQFGESSSCCPRDELIP--SGGPPVSVECTPHSPPVQVPTNRTSQRAALWERWNPWR 256

Query: 146 MMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDER--------- 196
            +   +       +    Y    E ++  +    +      + R   +            
Sbjct: 257 TVRRRQEFGSVCKEGQLRY---LEVDDTISDTAPQWQRCRLQVRRTNEHSASQRYLLELY 313

Query: 197 -PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPL 255
            PP++Y  P         K      ++         V ++         + D     S  
Sbjct: 314 DPPKDYRMPKISVHCSDIKEIRRCNRLEMPDNMNTFVLKVAGLTGGFIFEADNEQQVSSW 373

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
                E  S++ +  +                    G         +        +    
Sbjct: 374 TTELRECMSSRSDNVDGEPFPVSDSLSAARRGSSDPGGQSP-----LGFGLAEQAYNKTH 428

Query: 316 LPLENQVWYHGAISRTDAENLLRLCK---EASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
             L +  W+HG ISR  A  L++        ++LVR SET + D+ L+        H++L
Sbjct: 429 HFLSSYSWFHGPISRVRAAYLVQHAGVSGHGNFLVRQSETRRGDYVLTFNYQGRAKHLRL 488

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
           S T+  +  +      F SV +++ H+ +  +P++     
Sbjct: 489 SLTEWGQCRVQ--HLRFPSVMDMLSHFRNCPIPLECGAAC 526


>UniRef50_D0IN15 Suppressor of cytokine signaling 6 n=4 Tax=Euteleostomi
           RepID=D0IN15_ONCMY
          Length = 515

 Score =  124 bits (310), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 79/443 (17%), Positives = 135/443 (30%), Gaps = 50/443 (11%)

Query: 2   QQEGGPVRS-APCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHR 60
           +++G   RS      G+L+        ++ + S     S     S    P   N   +  
Sbjct: 57  EEKGPKNRSEGESLMGSLKRRLSAKQKNKIKESSTSVTSEDDTFSCSSAPIFFNDVKSQH 116

Query: 61  EPISSS----PQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLA--ILEDYADPFDV 114
              S+S    P P A      +++  R     ++  +    +P P    IL+++ DP   
Sbjct: 117 HLRSNSHHYSPTPWALRAANSEETCIRMDG--KVKAMIHSSDPSPSLNGILKEFPDP--- 171

Query: 115 QETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDG 174
           Q              +  +    ++          +      A+Q    Y  P + E D 
Sbjct: 172 QRDTLFQDSTENTKPQNGDLHLGID-------HENVPAIIGLASQDYIHYAMPIDDELDP 224

Query: 175 ATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQ 234
           A                 D   P  E  QP ++      +    +  +  D+   P V +
Sbjct: 225 AEG--------------LDSSSPMHEVPQPEQFPPFADEEPIDQEKLISPDIFMDPSVNR 270

Query: 235 LDSSPSLPDGDRDISGPASPLPEPSLEDSS--AQFEGPEKSCLSPGREEKGRLPPRLSAG 292
           L S             P      P    S     F     S  S G E            
Sbjct: 271 LLSDAECALIQDSRIEPPLSPLLPLPPGSHIRRSFLVYGGSSHSHGAERVLHHLNFDPNS 330

Query: 293 NPKSAKPLSMEPSSPLGEWTDPALPLE---NQVWYHGAISRTDAENLLRLCKEASYLVRN 349
            P   +       S     T P + L+    Q WY G I+R +AE  L    + S+LVR+
Sbjct: 331 APGVGRVYDAVQHSGPMIVTSPTVELKKLAEQGWYWGPITRWEAEEKLASLPDGSFLVRD 390

Query: 350 SETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS-PPFSSVPEIVH----------- 397
           S   +   SLS +S    +H ++  +        Q       S+ E++            
Sbjct: 391 SSDDRYLLSLSFRSQGKTLHTRIEHSNGSFSFYEQPDVEGHISIVELIECSIIDSESGAF 450

Query: 398 HYASRKLPIKGAEHMSLLYPVAI 420
            Y+  + P      + L  P++ 
Sbjct: 451 CYSRSRTPGTAMYPVRLTNPISR 473


>UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3 n=43
           Tax=Euteleostomi RepID=BCAR3_HUMAN
          Length = 825

 Score =  124 bits (310), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 42/244 (17%), Positives = 78/244 (31%), Gaps = 10/244 (4%)

Query: 185 PRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLD--SSPSLP 242
           P   + P            P    +    +  ++   + +    PPP+   D  S     
Sbjct: 14  PVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTL 73

Query: 243 DGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSM 302
              +     +    +   E       G   +   P   +      + S       +    
Sbjct: 74  PHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEK 133

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
                  E    +  L +  WYHG I R  +ENL++  ++  +LVR+S +S  +F L+ +
Sbjct: 134 LKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQ 191

Query: 363 SSQGFMHMKLSRT------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLY 416
                 H K++RT         +         F S+P +V  Y   + PI       +  
Sbjct: 192 WKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQ 251

Query: 417 PVAI 420
           P+  
Sbjct: 252 PINR 255


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score =  124 bits (310), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 34/148 (22%), Positives = 57/148 (38%), Gaps = 9/148 (6%)

Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
                 +   F    +  LS    +  ++    S      A+  S E   P        +
Sbjct: 14  HNMEAIAKFDFTASGEDELSFQAGDVLKIL--SSQEEWYKAELRSHEGYVP-----KNFI 66

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
                 W+   ISR +AENLL       ++VR S+ S  DFS+S++      H K+ R  
Sbjct: 67  DFHVPHWFDEKISRHEAENLLMSKGVGCFVVRASQNSHGDFSISVRHEDDVQHFKVMRDS 126

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +  Y L      F S+ ++V +Y +  +
Sbjct: 127 KGSYYLWTE--KFHSLNKLVDYYKTSSI 152


>UniRef50_UPI0001925BB9 PREDICTED: similar to Shb=Src homology 2 protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001925BB9
          Length = 419

 Score =  124 bits (310), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 79/379 (20%), Positives = 127/379 (33%), Gaps = 65/379 (17%)

Query: 18  LEGSRQGSPGHRKRASPKGSLSSAQPHSWMLTPS---PLNSHCAHREPISS--------- 65
           L G +        +        S    S  L  +   P ++  +  +  +S         
Sbjct: 72  LTGKKLQIKKDEYQDPWDSKEMSNNDKSSKLNDTYEDPFDAMKSENDLQTSKTLKTSKST 131

Query: 66  -SPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGA 124
            +       P       W + +      L ++    P    +DY+DP+D ++    S   
Sbjct: 132 DNENDSKTLPSDTYIDPWDTFSGKNKKDLENKQNSVPTKKKDDYSDPWDSKKCTSKSYDE 191

Query: 125 SGAPEKVPENDGYMEPYEAQK---MMAEIRGSKETATQPLPLYDTPYE--------PEED 173
                    +D Y EPY+  K   M +    S+    +   LYD PYE        P+ +
Sbjct: 192 F--------DDTYSEPYDKNKHTVMDSTPHASESDVEEHAELYDMPYEERVILGVEPKIN 243

Query: 174 GATAEGEGAPWPRESR----------LPEDDERPPEEYDQPWEWKKERISKAFAVDIKVI 223
           G          P   +                    EYD PWEWK + +   F     V 
Sbjct: 244 GNLKNPAPHLQPVPPQHAPYSSAKPKPSSSILPTAGEYDAPWEWKMKDVEADFEKRFSVG 303

Query: 224 KDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKG 283
            +         L+SS         +   +      ++  +  Q        +S  + E  
Sbjct: 304 VESASSIKP-PLNSSHPNKKPVPAVRNQSITSINTAVVANPVQKPARSNKDVSVSKAEDL 362

Query: 284 RLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEA 343
                                        DP +PL+NQ W+HGAI R  AE+LL+   + 
Sbjct: 363 SRKEY----------------------EVDPTIPLKNQGWFHGAIRRDYAEDLLKSMPDC 400

Query: 344 SYLVRNSETSKNDFSLSLK 362
           SYL+R+SE+SK ++SLSLK
Sbjct: 401 SYLIRDSESSKLNYSLSLK 419


>UniRef50_C4Q6F0 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4Q6F0_SCHMA
          Length = 1070

 Score =  123 bits (309), Expect = 8e-27,   Method: Composition-based stats.
 Identities = 52/148 (35%), Positives = 83/148 (56%), Gaps = 4/148 (2%)

Query: 274  CLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDA 333
              SP             + N   +   S+    P        LPLE Q W+H  ++R++A
Sbjct: 926  DQSPSSNVNLHHSMNPVSKNKLLSSQNSLPKGLPPH---LETLPLEEQPWFHPLLTRSEA 982

Query: 334  ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
            E L+R   E S+LVR SET  NDFSL++K  + F+HMK++R    +++LG+ S P++SV 
Sbjct: 983  EELIRNEPEGSFLVRPSETCPNDFSLTIKH-KSFLHMKITRNSTGQFILGEYSQPYASVS 1041

Query: 394  EIVHHYASRKLPIKGAEHMSLLYPVAIR 421
            ++++HYA   +P+ GA  ++L +PV  R
Sbjct: 1042 QMIYHYARTLVPVLGAYSVTLTHPVCKR 1069


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  123 bits (309), Expect = 8e-27,   Method: Composition-based stats.
 Identities = 44/227 (19%), Positives = 78/227 (34%), Gaps = 20/227 (8%)

Query: 200 EYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPS 259
           + ++P + K +       V  +     P PP V     +P  PD   D         +  
Sbjct: 10  DKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLD--------EDKH 61

Query: 260 LEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLE 319
              +   +       L   + EK ++  + +     +   ++         +      LE
Sbjct: 62  FVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDWWLARSLVTGREGYVPSNFVARVESLE 120

Query: 320 NQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLK----SSQGFMHMKLS 373
            + W+  +  R +AE  L        S+L+R SET+K  FSLS+K      +   H K+ 
Sbjct: 121 MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR 180

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
              E  Y +      F S+  +V HY+ +           L  P   
Sbjct: 181 CLDEGGYYIS-PRITFPSLQALVQHYSKKG----DGLCQRLTLPCVR 222


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  123 bits (309), Expect = 9e-27,   Method: Composition-based stats.
 Identities = 30/163 (18%), Positives = 64/163 (39%), Gaps = 5/163 (3%)

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR--LSAGNPKSAKPLSMEPSSPLG 309
            S   +  +  +   +    K  LS  + +  ++        G   +    + +      
Sbjct: 1   MSATKKNDIFVALDDYASQHKGELSFSKGDNFKILKNAAPDDGWWNAQNLNTKKKGWIPC 60

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
                   LE   W HGAISR  A+ LL +   +  YLVR S++    ++L +      +
Sbjct: 61  SLVALDGSLELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQPGQYTLDVWKEGKSV 120

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH 411
           H ++++  E  +   +    F ++PE++ H+ +R   +  +  
Sbjct: 121 HYRITKGDEGYFF--RQGVCFPTIPELIQHHQTRSDGLCSSLD 161


>UniRef50_D2H965 Putative uncharacterized protein (Fragment) n=3 Tax=Amniota
           RepID=D2H965_AILME
          Length = 453

 Score =  123 bits (309), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 54/331 (16%), Positives = 100/331 (30%), Gaps = 33/331 (9%)

Query: 113 DVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLP---------- 162
           +  +T            +  +N  Y +  E + +    R +     + +P          
Sbjct: 123 NSLKTKSQYYDLQAPDTQETQNI-YTKAAEEEGLGKGPRPAPLLEEEKIPSLSSSSRNIQ 181

Query: 163 --LYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI 220
             L D+    +  G   + E     ++  L + DE    +  + W   KE      ++  
Sbjct: 182 QMLADSINRMKAYGFHQKKESVKKTQDEELKQIDEEKTMQIYKSW---KEDSDWQASLRK 238

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
               D        Q            +  G       P       +              
Sbjct: 239 SKAADEKRRSLAKQAREDYKRLSLVAEKGGSNEEPRSPPGVPQKPKRPPLPPKPHFLS-- 296

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSS-PLGEWTDPALPLENQV---------WYHGAISR 330
                 PR   G     +  S       +  + +  LPL             W+HG ++ 
Sbjct: 297 --PAGYPRNPLGKQGVTRTASGSAREDIIRWFKEEQLPLRAGYQRTSDTIAPWFHGILTL 354

Query: 331 TDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFS 390
             A  LL  C+  S+L+R SE  K  ++LS  S  G  H  +  + +    LG +    +
Sbjct: 355 KRANELLSTCEPGSFLIRVSERIKG-YALSYLSEDGCKHFLIDASADSYSFLGVDRLRHA 413

Query: 391 SVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           ++  +V ++    +   G E   LLYP   +
Sbjct: 414 TLAALVDYHKEEPITSLGKE--LLLYPCGQQ 442


>UniRef50_P42680 Tyrosine-protein kinase Tec n=85 Tax=Coelomata RepID=TEC_HUMAN
          Length = 631

 Score =  123 bits (309), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 41/222 (18%), Positives = 77/222 (34%), Gaps = 16/222 (7%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
            R ++  A   +               +  +                   +  +   F+ 
Sbjct: 133 CRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQA 192

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT-DPALPLENQVWYHGAI 328
            E   L   R ++  +  +      ++      E   P    T   +  L+   WY   +
Sbjct: 193 AEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNM 252

Query: 329 SRTDAENLLRLC-KEASYLVRNSETSKNDFSLSLKSS------QGFMHMKLSRTKE--HK 379
           +R+ AE LLR   KE  ++VR+S +    +++SL +        GF H  +  T     K
Sbjct: 253 NRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKK 311

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           Y L +    F S+PEI+ ++              L YPV+++
Sbjct: 312 YYLAEKH-AFGSIPEIIEYHKHN----AAGLVTRLRYPVSVK 348


>UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Fragment)
           n=8 Tax=Euteleostomi RepID=Q5T4P3_HUMAN
          Length = 206

 Score =  123 bits (308), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 4/119 (3%)

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN-SETSKNDFSLSLK 362
            S+      D ++ L++  WY G ISR +  + LR   + ++LVR+ S   + D++L+L+
Sbjct: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR 105

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAI 420
                  +K+   ++ KY        F+SV E+++HY    L        + L+YPV+ 
Sbjct: 106 KGGNNKLIKI-YHRDGKYGFSDP-LTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSR 162


>UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepID=Q05DQ0_HUMAN
          Length = 283

 Score =  123 bits (308), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 32/119 (26%), Positives = 59/119 (49%), Gaps = 4/119 (3%)

Query: 304 PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN-SETSKNDFSLSLK 362
            S+      D ++ L++  WY G ISR +  + LR   + ++LVR+ S   + D++L+L+
Sbjct: 46  TSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR 105

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAI 420
                  +K+   ++ KY        F+SV E+++HY    L        + L+YPV+ 
Sbjct: 106 KGGNNKLIKI-YHRDGKYGFSDP-LTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSR 162


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  123 bits (308), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 46/289 (15%), Positives = 101/289 (34%), Gaps = 12/289 (4%)

Query: 139 EPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPP 198
             YE +++   +            L  T  E     A   G       + R         
Sbjct: 162 PEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFL 221

Query: 199 EEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEP 258
            + +    ++   +   + +  +    L          S     +       P  P+ + 
Sbjct: 222 SQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDR 281

Query: 259 SLEDSSAQFEGPEK-SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDP--- 314
               +   +        +S  + +   +   L  G        + E    + +  +    
Sbjct: 282 RRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGR 341

Query: 315 -ALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
              P E ++W+HG IS+ +A NLL    +  S+LVR S+ +  D+SL  ++++     K+
Sbjct: 342 EEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKI 401

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
             T  +++++G     ++S+ +I+ HY   ++     E   L  PV ++
Sbjct: 402 CPTPNNQFMMG--GRYYNSIGDIIDHYRKEQIV----EGYYLKEPVPMQ 444



 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 37/122 (30%), Positives = 52/122 (42%), Gaps = 9/122 (7%)

Query: 301 SMEPSSPLGEWTD-PALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFS 358
           S++      E    P        WYHG + RT AE  LR   K  SYL+R S+     F 
Sbjct: 158 SLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFV 217

Query: 359 LSLKSS-QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           LS  S      H ++       Y+       FSS+ +++ +Y+     +KG     LLYP
Sbjct: 218 LSFLSQMNVVNHFRIIAMCGDYYI---GGRRFSSLSDLIGYYSHVSCLLKGE---KLLYP 271

Query: 418 VA 419
           VA
Sbjct: 272 VA 273


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  123 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 30/146 (20%), Positives = 58/146 (39%), Gaps = 9/146 (6%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
               +   F    +  LS    +  ++              L  +       + D    +
Sbjct: 1   MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE---LGSQEGYVPKNFID----I 53

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
           +   W+H  +SR  AENLL   +   +++R S++S  DFS+S++      H K+ R  + 
Sbjct: 54  QFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKG 113

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKL 404
            Y L      F S+ ++V +Y +  +
Sbjct: 114 NYFLWTE--KFPSLNKLVDYYRTNSI 137


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  123 bits (307), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 33/141 (23%), Positives = 59/141 (41%), Gaps = 3/141 (2%)

Query: 280 EEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL-LR 338
            EK    P L     ++ +       +   +          + W+HG +S  +AE L L 
Sbjct: 68  GEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILE 127

Query: 339 LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHH 398
             K  S+LVR S++   DF LS+++     H+ + R ++ KY +G     F ++ E++ H
Sbjct: 128 RGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMI-RWQDKKYDVGG-GESFGTLSELIDH 185

Query: 399 YASRKLPIKGAEHMSLLYPVA 419
           Y    +       + L  P  
Sbjct: 186 YKRNPMVETCGTVVHLRQPFN 206



 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 4/104 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRK-LPIKGAEHMSLLYPVA 419
           +   + G     F+++PE+V +Y     L  K  + + L  P+ 
Sbjct: 61  DFFDLYGGE--KFATLPELVQYYMENGELKEKNGQAIELKQPLI 102


>UniRef50_Q4SIP6 Chromosome 21 SCAF14577, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SIP6_TETNG
          Length = 608

 Score =  123 bits (307), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 41/220 (18%), Positives = 79/220 (35%), Gaps = 12/220 (5%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDI-SGPASPLPEPSLEDSSAQFE 268
               ++    +   + L +   + Q  + P          S P   + E SL   +  F 
Sbjct: 395 AEDEQSRTCWMTAFRLLKYGIVLYQSYNVPQQRKSSLPPFSAPVRSVSENSLV--AMDFS 452

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAI 328
           G     +    E +            +S +   +   SP+   +  A     QVW+HG I
Sbjct: 453 GRTGRIIDNPVEAQSAALEEGQTWRKRSQRMNVLGSPSPMHPSSLSAAIHRTQVWFHGRI 512

Query: 329 SRTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH---KYVLG 383
            R +A  ++  +   +  +L+R+S+++   F L+L   Q   H ++   +E     + L 
Sbjct: 513 VREEAHKMIIQQGQVDGLFLLRDSQSNPRAFVLTLCHHQKIKHFQILPCEEDGQVFFSLD 572

Query: 384 QNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
             S  F+ +  +V  Y   +    G     L +P     L
Sbjct: 573 DGSTKFTDLIHLVDFYQLNR----GVLPCKLKHPCTAVAL 608


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score =  122 bits (306), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 4/111 (3%)

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN-SETSKNDFSLSLKSSQGFMHM 370
            D  + L++  WY G ISR +  + LR   + ++LVR+ S   + D++L+L+       +
Sbjct: 54  KDSFISLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLI 113

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAI 420
           K+   ++ KY   +    F+SV E+++HY    L        + L YPV+ 
Sbjct: 114 KI-YHRDGKYGFSEP-LTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSR 162



 Score =  108 bits (268), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 29/129 (22%), Positives = 55/129 (42%), Gaps = 3/129 (2%)

Query: 294 PKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS 353
               K    + S  + E  +     + + W+   I+R  AE+LL    + ++L+R S + 
Sbjct: 270 WLGIKNEDSDESYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SK 328

Query: 354 KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHM 412
           K  ++ S+ +     H  +  T    Y   +    +SS+ E+V HY    L     + ++
Sbjct: 329 KGCYACSVVADGEVKHCVIYSTARG-YGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNV 387

Query: 413 SLLYPVAIR 421
            L YPV  +
Sbjct: 388 RLAYPVHAQ 396


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score =  122 bits (306), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 34/159 (21%), Positives = 63/159 (39%), Gaps = 8/159 (5%)

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAI 328
               S +          P  +++ NP   +       +   E +  A  L +  WYHG +
Sbjct: 187 ANIDSEMEHNSGSNASTPIAVNSPNPNEQQEAIALKKALEWELSLDARELRSHAWYHGPL 246

Query: 329 SRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR------TKEHKYVL 382
            R  AE +++  +E  +LVR+  +  +++ LS +S    +H  L++      T   +   
Sbjct: 247 PRQRAEEIVQ--REGDFLVRDCASQPDNYVLSCRSKLAVLHFVLNKLVLQPETVYERVQY 304

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
                 F +VP+++  Y     PI  A    + YP   R
Sbjct: 305 QFEEDAFDTVPDLITFYVGSGKPISAASGALIQYPCNRR 343


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  122 bits (304), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 27/177 (15%), Positives = 63/177 (35%), Gaps = 17/177 (9%)

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
                +  +  +   F    ++ LS    E+  +         K +   + +       +
Sbjct: 23  NQAAADKCIFVALYNFPLSGQTDLSIHFGEQLNILSE-DGDWLKVSSASTGQECYLPTNY 81

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLK-----SS 364
                      W +  I+R  AE LL +      S+L+R SET    ++LS++     S 
Sbjct: 82  VAKV----CNRWLYKGINREKAEELLMVNSNRSGSFLIRESETRSGSYTLSIRKTNHTSR 137

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
               H ++ +     + +      F+++ ++V +Y+     +      +L  P  ++
Sbjct: 138 DSIKHYRIHQLDNGWFYIA-PRLTFATLQDMVDYYSE----VADGICCTLTEPCVVQ 189


>UniRef50_Q5BWZ4 SJCHGC04657 protein (Fragment) n=1 Tax=Schistosoma japonicum
           RepID=Q5BWZ4_SCHJA
          Length = 153

 Score =  122 bits (304), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 55/136 (40%), Positives = 86/136 (63%), Gaps = 2/136 (1%)

Query: 288 RLSAGNPKSAKPLSMEPSSPLG-EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
           R S  +    K LS + + P G       LPLE Q W+H +++R++AE L+R   E S+L
Sbjct: 19  RHSMHSVSRNKLLSSQNNLPKGLPSHLEKLPLEEQPWFHPSLTRSEAEELIRNEPEGSFL 78

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           VR SET  NDFSL++K  + F+HMK++R    +++LG+ S P+SSV ++++HYA   +P+
Sbjct: 79  VRPSETCPNDFSLTIKH-KTFLHMKITRNNAGQFILGEYSQPYSSVSQMIYHYARTLVPV 137

Query: 407 KGAEHMSLLYPVAIRT 422
            GA  ++L +PV  R 
Sbjct: 138 LGAYSVTLTHPVFKRV 153


>UniRef50_UPI000186F2CC Phosphatidylinositol 3-kinase regulatory subunit alpha, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186F2CC
          Length = 726

 Score =  121 bits (303), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 16/149 (10%)

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
             L P +  +    P       +  +  + +              L++  WY G I+R +
Sbjct: 286 PILPPRKVSRPGPHPYRDDLELERDRDSAQQQ-------------LKDAEWYWGDITREE 332

Query: 333 AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSV 392
               L    + ++LVRN+     +++L+L+       +K+   K  KY   +    F+SV
Sbjct: 333 VNEKLMNTPDGTFLVRNASNKGGEYTLTLRKGGTNKLIKICH-KNGKYGFSEPY-KFNSV 390

Query: 393 PEIVHHYASRKLPIKGA-EHMSLLYPVAI 420
            E+V  Y +  L    +   + LLYPV+ 
Sbjct: 391 VELVKFYKTSSLAQYNSTLDIKLLYPVSR 419



 Score = 98.2 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 31/130 (23%), Positives = 52/130 (40%), Gaps = 5/130 (3%)

Query: 294 PKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETS 353
           P+S  P  +                E  +W     SR  A  LL    E ++LVR S + 
Sbjct: 583 PESLTPWGLRELETDENLKSMPHQNE-YLWNLPECSRAQAATLLESKPEGTFLVRPSSS- 640

Query: 354 KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HM 412
              ++LS+  +    H  + +T    +   +    + S+ ++V HYA+  L     E   
Sbjct: 641 -GQYALSIVCNGVINHCIIYQTDRG-FGFAEPYNIYPSLKQLVLHYANNSLEEHNEELKT 698

Query: 413 SLLYPVAIRT 422
           +L+YPV   T
Sbjct: 699 TLMYPVFALT 708


>UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4QQ21_SCHMA
          Length = 1124

 Score =  120 bits (301), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 76/385 (19%), Positives = 135/385 (35%), Gaps = 23/385 (5%)

Query: 38   LSSAQPHS-WMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDR 96
            LS  + H     + +P  S  ++   ++ S  P     +Q +         +      D 
Sbjct: 756  LSPTRTHKEHFTSRNPPTSKNSNVLLMTQSSLPAGFPEQQPEY-------FIHYRHKSDN 808

Query: 97   LEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKET 156
            L       + D        +                EN    +      ++A    +  T
Sbjct: 809  LVHTNPNFVTDTRSTRMSGDCTHVQYYPQRNRSYNSENSCMTD------LIAPSYNNSMT 862

Query: 157  ATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAF 216
             +   PL       +     +        R + +    +R  +   Q    +  ++S + 
Sbjct: 863  QSVFFPLDSGWGPTDVKSNDSTSAKHKKHRSNMIRSHSQRTADP--QSNLLEGNQLSTSS 920

Query: 217  AVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLS 276
                 +I    +   + Q   +    +              P++  SS  F        S
Sbjct: 921  DHTRCLIPSKYYHRNLSQTVPANPDSNSIWPPVLVQWHRRRPNVAASSENFPDIIDYQGS 980

Query: 277  PGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL 336
                E   +P              S          T  +  LENQ+W+H  +SR+ AE L
Sbjct: 981  KRYNENLHIPAE------YYRHQKSDFSRHHSSSTTAISEQLENQLWFHRDLSRSHAEKL 1034

Query: 337  LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQNSPPFSSVPEI 395
            L+     S+LVR SETSK + SLS+K     +HMK+S+  E   YVLG+ S P+ SV  +
Sbjct: 1035 LKSTPTGSFLVRRSETSKTELSLSIKRESDVLHMKISQDPETGGYVLGEYSQPYPSVSSM 1094

Query: 396  VHHYASRKLPIKGAEHMSLLYPVAI 420
            ++ Y+   LP++G   + L +P++ 
Sbjct: 1095 IYRYSRTLLPVRGTTPVLLRFPISR 1119


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score =  120 bits (301), Expect = 8e-26,   Method: Composition-based stats.
 Identities = 58/319 (18%), Positives = 107/319 (33%), Gaps = 29/319 (9%)

Query: 110 DPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTP-- 167
            P       EG        + + +N    +P+  +  +   R         L LYD P  
Sbjct: 185 RPDVGDCCKEGQLRYLLVDDTISDN----QPHWQRCRLLVRRIRDSQEKYVLELYDPPKA 240

Query: 168 YEPEEDGATAEGEGAPWPRESRLPEDD---------------ERPPEEYDQPWEWKKERI 212
             P+     ++ +         +P++                E   ++    W  + +  
Sbjct: 241 SSPKLTSQCSDIQEVRRCNRLEMPDNINTFVLKVVRQGSWIFETDNDQQVSSWTTEIKEC 300

Query: 213 SKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK 272
                 ++           +     SP  P           PLP      + A   G  +
Sbjct: 301 VNNRDTEVASCLSGAAAFNLQNSAVSPRCPSTSSSAGADVEPLPTTPDFTAPAGHRGSAE 360

Query: 273 -SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
               S  R  +          + + A P S+ P  P  + TD    L +  W+HG ISR 
Sbjct: 361 LGGQSKTRSSRPGSGFLGLIPSLRPADPASLPPPEPAVQKTD--HFLFSYPWFHGPISRV 418

Query: 332 DAENLLRL---CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP 388
            A +L++         +LVR SET + D+ L+        H++LS T+  +  +      
Sbjct: 419 KAAHLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAKHLRLSLTEWGQCRVQ--HLR 476

Query: 389 FSSVPEIVHHYASRKLPIK 407
           F SV +++ H+    +P++
Sbjct: 477 FPSVMDMLSHFRLYPIPLE 495


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  120 bits (300), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 5/111 (4%)

Query: 311 WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
           +  P   LE   WYHG +SR  AE LL      S+LVR SE+S    S+SL+      H 
Sbjct: 1   YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY 60

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +++   + K  +   S  F+++ E+VHH+++    +      +L YP   R
Sbjct: 61  RINTASDGKLYVSSES-RFNTLAELVHHHST----VADGLITTLHYPAPKR 106


>UniRef50_UPI000180B9A8 PREDICTED: similar to Protein vav-2 n=1 Tax=Ciona intestinalis
           RepID=UPI000180B9A8
          Length = 938

 Score =  120 bits (300), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 52/251 (20%), Positives = 91/251 (36%), Gaps = 12/251 (4%)

Query: 157 ATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAF 216
           A +   LY  P          +      P + +  E    PP    QP +          
Sbjct: 574 AVRASRLY-PPNAGSSGPEVPQRGKRTRPFDKKPMEAPSIPPSIPTQPLKAAAAVPPPTM 632

Query: 217 AVDIKVIKDLPWPPPVGQLD---SSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKS 273
               +     P PP  G +    SS      D +++         +  D    F     S
Sbjct: 633 YRAHRDYNGNPRPPFPGVMTISFSSHEYVMVDEEVNSDWWLGHTTTDLDRKGYFPASFVS 692

Query: 274 CLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDA 333
            ++       R    + +   +  +  +  P +P  +    A+PLE  +WY G + R +A
Sbjct: 693 PVTTKSSRPERSNNDIQSVPGEFPRRSNHPPVTPPQQ----AIPLEENIWYAGTMDRGEA 748

Query: 334 ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
           ENLL      ++LVR   T     ++SL  S+   H++++R+ E  Y +      F SV 
Sbjct: 749 ENLLHDKPSGTFLVR---TRDGHLAISLIYSKEMKHIRINRSSEGLYFVA-ECKNFKSVQ 804

Query: 394 EIVHHYASRKL 404
           E++ +Y    +
Sbjct: 805 ELIRYYRENSM 815


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  120 bits (299), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 39/148 (26%), Positives = 63/148 (42%), Gaps = 5/148 (3%)

Query: 274 CLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDA 333
            + P            S  +       S + S    + +   + LE++ WYHGAI R+ A
Sbjct: 118 PVPPNDHSTTLNTGSASGSSLTFQHTSSHDVSCNGSQGSLARVGLESEKWYHGAIQRSYA 177

Query: 334 ENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
           E LL      S+L+R SE+     ++SL+      H ++ R   + Y +   S  F+SV 
Sbjct: 178 EYLLNSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDDSNMYYVI-ESNKFTSVS 236

Query: 394 EIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           ++VHH+             +LLYP   R
Sbjct: 237 DLVHHHEKHS----DGLACTLLYPAPKR 260


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score =  119 bits (298), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 31/101 (30%), Positives = 54/101 (53%), Gaps = 3/101 (2%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
           +  W+H +++ + AE LL    + S+LVR SE+   DF++S+K +    H+K+    +  
Sbjct: 2   SLKWFHSSLNGSQAEELLTPLADGSFLVRPSESKHGDFTISVKCNGKVTHIKIQNDGDSF 61

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM--SLLYPV 418
            ++G    PF ++  +V HY +    IK    +   LLYPV
Sbjct: 62  LLIGSPD-PFPTLESLVSHYRNTPNSIKEKSGVFIELLYPV 101



 Score =  103 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 10/154 (6%)

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
           S       E      R +  + K    + +E   P+      +     + WYHG+I   +
Sbjct: 66  SPDPFPTLESLVSHYRNTPNSIKEKSGVFIELLYPVR-----STDPTTERWYHGSIGAKE 120

Query: 333 AEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSS 391
           AE  LL   +  SYLVR S++    F L +K + G   + +S  +  KY + ++ P F+S
Sbjct: 121 AERMLLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQVIIS-CRNKKYEI-KSGPSFAS 178

Query: 392 VPEIVHHYASRKLP--IKGAEHMSLLYPVAIRTL 423
           + E++ +Y        +K    + L  P    + 
Sbjct: 179 LQELIEYYVMNPKLHDVKDQSPIKLREPFQSTSF 212


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score =  119 bits (298), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 32/191 (16%), Positives = 63/191 (32%), Gaps = 12/191 (6%)

Query: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
              P L               +     S   F           +     +  ++S  +  
Sbjct: 43  TGLPPLASTPPRSPRIVGTPNQTPGSPSRPHFRYSSIPEDHFSKPPPSPIRTKMSLQDMT 102

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKN 355
                 +       E+  P+  + +  W+HG ISR  AE L+R  +   +LVR+S +   
Sbjct: 103 PEDLRKLLE----EEFKLPSEDVRSHAWFHGGISREKAEKLIR--ENGDFLVRDSISKPG 156

Query: 356 DFSLSLKSSQGFMHMKLS------RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA 409
           +F L+++     MH  ++       +             F ++P ++  Y     P+  A
Sbjct: 157 NFVLTVRWKGVSMHFVVNKVVLKAHSPYASVQYQFEKECFDAIPSLIKFYVGNCRPVSQA 216

Query: 410 EHMSLLYPVAI 420
               + +PV  
Sbjct: 217 SGAVIQHPVNR 227


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 33/111 (29%), Positives = 58/111 (52%), Gaps = 6/111 (5%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
                L+ ++W+HG++SR +AE++L   ++  +LVR S+ S   + L+  ++    H+ L
Sbjct: 336 SQKQQLKQEIWFHGSVSRAEAESML--TRDGDFLVRESQGSPGQYVLTGMNNNTPKHLLL 393

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM-SLLYPVAIRT 422
               E   V+      F SV  +V+H+    LPI  A+ +  L YP+  RT
Sbjct: 394 I-DPEG--VVRTKDRVFDSVSHLVNHHCDNVLPIISADSVLVLRYPIPRRT 441


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 37/199 (18%), Positives = 71/199 (35%), Gaps = 26/199 (13%)

Query: 245 DRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP-RLSAGNPKSAKPLSME 303
                   +      +  +   F+      LS  + E+  +        +   A+  S  
Sbjct: 200 QAPPPKLQASRSSFEVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGT 259

Query: 304 PSSPLGEWTDP----------------------ALPLENQVWYHGAISRTDAENLLRLCK 341
                  + +                        +P+E Q WY G ISR  AE+LL   +
Sbjct: 260 TGLVPRNYIEVVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWYFGRISRERAEDLLLHGR 319

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           E  +LVR+SE++  D S+S++  +   H K+        +L   +  F  +  +++HY +
Sbjct: 320 EGEFLVRDSESNPGDLSISMRGIERNKHFKVQNVDG---LLKIGNRTFVDMNALINHYTT 376

Query: 402 RKLPIKGAEHMSLLYPVAI 420
             +     E + L  P+  
Sbjct: 377 SPIFSSPTEKLFLTGPLPK 395


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 3/98 (3%)

Query: 323 WYHGAISRTDAENL-LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
           W+HG +S  +AE L L   K  S+LVR S++   DF LS+++     H+ + R  E+KY 
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRTEDKVTHVMI-RWHENKYD 116

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           +G     F ++ E++ HY    +       + L  P  
Sbjct: 117 VGG-GQKFGTLCELIEHYKRNPMVEICGTVVHLRQPFN 153


>UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containing 4B n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A0859
          Length = 488

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 53/287 (18%), Positives = 96/287 (33%), Gaps = 32/287 (11%)

Query: 138 MEPYEAQKMMAEIRGSKETATQ-PLPLYDTPYEPEEDGATAEGEGAPWPRESRLPE--DD 194
           ME  +A K++ E    +    Q    LY T  + +    T+E E   W  + R  +  D+
Sbjct: 220 MEDRKAAKVLEERIREEFKEEQRAKELYWTLKQAQLQSGTSEHEEREWEEQLRRSKAADE 279

Query: 195 ERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASP 254
           ER         E+++  +       +  +  +           +            P   
Sbjct: 280 ERSRGAQRARDEYRRHSLRAIQKGTVAGLSSMFQELGQSHEQEARLYHHLPGPGPPPPLA 339

Query: 255 LPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDP 314
           +P  +                    E   R   R         + L           +  
Sbjct: 340 IPVRTW-------------------ERPLRPVSREVIVRWFKEEQLPRRAGFERNTKSIA 380

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
                   W+HG ISR DAE+LL    E ++LVR SE     ++LS +  +GF H  +  
Sbjct: 381 P-------WFHGIISREDAEDLLENMTEGAFLVRVSEKIWG-YTLSYRLQKGFKHFLVDA 432

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           + +    LG +    +++ +++  +    + + G E   L  P   R
Sbjct: 433 SGDFYSFLGVDPNRHATLTDLIDFHKEEIITVSGGE--LLQEPCGQR 477


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 50/320 (15%), Positives = 105/320 (32%), Gaps = 19/320 (5%)

Query: 110 DPFDVQETGEGSAGASGAPEKVPENDGYM-----EPYEAQKMMAEIRGSKETATQPLPLY 164
           +P +            G  ++   N+ Y+     +  +  ++                 +
Sbjct: 104 EPQNSNHIPNLKPPGDGG-DRAHMNEEYVSKFNYDATKDDELTLRKGMRVIVLQTDPDGW 162

Query: 165 DTPYEPEEDGATAEGEGAPWPRESRLPED--DERPPEEYDQPWEWKKERISKAFAVDIKV 222
               + E  G           + S +P+      P   + QP       +   +A +   
Sbjct: 163 WYGKDAERPGQPGYFPSNYVVKSSSMPQSCPSSMPNTSHVQPASDCISVVRTLYAFNSGN 222

Query: 223 IKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEK 282
            ++L +              D +  ++  +  L      +     +G +       +   
Sbjct: 223 PEELAFEQDEMLDIIEQPPDDPEWWLARNSEGLTGLVPMNYVEVVDGAQPVSSGNIQNYD 282

Query: 283 GRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE 342
              P      N  +        ++ +G     A  + ++ WY G + R DAE  L+   +
Sbjct: 283 RVCPQHNDIENMHA-------QNTAIGGNDGAADGIHSRDWYFGNMKRADAEQRLQDRAD 335

Query: 343 -ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
              +LVR SETS  D+S+S+K      H K++      + +GQ    F S+  ++ HY S
Sbjct: 336 NGEFLVRGSETSSGDYSISMKMPGRIRHFKVNTLPNGVFGIGQ--RKFDSMDALLEHYKS 393

Query: 402 RKLPIKGAEH-MSLLYPVAI 420
             +     +  + L  P+  
Sbjct: 394 APIYTSKEQGKVYLSKPMGR 413


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 41/200 (20%), Positives = 75/200 (37%), Gaps = 13/200 (6%)

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
           P P    +  P +P   +    P+SPLPE  L  +  +++      L   + EK ++   
Sbjct: 27  PKPPVSQNFDPLIPYPSQYTPPPSSPLPEN-LVVAIYKYDPAHSDDLGFEKGEKMKILDC 85

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYL 346
                  +    + +       +      +E + W++  +SR DA   L        S+L
Sbjct: 86  DDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFL 145

Query: 347 VRNSETSKNDFSLSLK-----SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           +R SET    FS+S++           H ++       + +  N   F+S+ E+V HY+ 
Sbjct: 146 IRESETQPGSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYI-TNKISFNSLSELVKHYSR 204

Query: 402 RKLPIKGAEHMSLLYPVAIR 421
                       L+ P   R
Sbjct: 205 E----ADGLCTRLVKPCQTR 220


>UniRef50_B3XVX8 Protein tyrosine kinase fes/fps n=1 Tax=Codonosiga gracilis
           RepID=B3XVX8_9EUKA
          Length = 792

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 37/201 (18%), Positives = 72/201 (35%), Gaps = 8/201 (3%)

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
           + P   P+  +++S +  D    +S       +      +  F     S  S        
Sbjct: 338 ESPLMLPIDGVNTSETATDSKTVLSKENILDTQQHTTQDAVTFCHVASSETSTTPPPSLP 397

Query: 285 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEAS 344
              R+  G P   K  SM+ ++  G+  D    +E+   Y G I R +   +L       
Sbjct: 398 TAERMPMGQPVVNKQTSMQLTA--GDGRDGGQSVEDLECYFGPIPRNEVPMILSD--PGD 453

Query: 345 YLVRN-SETSKNDFSLSLKSSQG-FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
           +L+R  SE S   + LS+    G   H  +         +      F S+  ++ HY   
Sbjct: 454 FLIRLGSENSATKYVLSVLEEGGNCRHFNIFYCPNGYVKI--EKQEFPSISHLIRHYIDN 511

Query: 403 KLPIKGAEHMSLLYPVAIRTL 423
            L +     +++ + V+ + +
Sbjct: 512 DLSLSKNSGVTIAHGVSRKKM 532


>UniRef50_UPI0001927133 PREDICTED: similar to predicted protein n=1 Tax=Hydra
           magnipapillata RepID=UPI0001927133
          Length = 521

 Score =  118 bits (295), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 39/225 (17%), Positives = 71/225 (31%), Gaps = 15/225 (6%)

Query: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
            ++                  D  +   LP  P +    +  ++     D       + +
Sbjct: 297 SDQEQISTSLNHTDRKSLKKDDRSMRPPLPPRPTISGPVNVSTVTRSQNDTVAIKRDVVK 356

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
           P+          PE+  +   +    R   R            S +              
Sbjct: 357 PTNRPP----PAPEQPDVVKNQIRPARPKNREEVSKWWKEIEYSRQAGL--------DKE 404

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
               +W+HG ISR +AE +L    + S+LVR SE     +++S K      H  +  +  
Sbjct: 405 FNPLLWFHGIISRHEAEKILEKKDKGSFLVRVSERVWG-YTVSFKDIARCKHFLIDTSAN 463

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
                G      +S+ E++ ++     PI G     L+YP    T
Sbjct: 464 GYQFFGTEQIVHNSLNELIDYHKIN--PISGLGQEILIYPCGQET 506


>UniRef50_UPI000051A4E9 PREDICTED: similar to lymphocyte cytosolic protein 2 n=1 Tax=Apis
           mellifera RepID=UPI000051A4E9
          Length = 624

 Score =  118 bits (295), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 76/395 (19%), Positives = 132/395 (33%), Gaps = 39/395 (9%)

Query: 36  GSLSSAQPHSWML----TPSPLNSHCAHREPISSSPQPVANGPKQK--KKSNWRSTTRLR 89
            +L+  QP    L    T S   +    R  +   PQP+ N  +    +KSN   T    
Sbjct: 233 SALNRTQPRKSFLHNTKTKSNNLAQTQKRMTVPPPPQPIKNKDQMVIIEKSNKDQTKPPA 292

Query: 90  IIRLRDRLEPRPLAI--LEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMM 147
            +R  D +   P      ED  + FD Q   +         +              Q + 
Sbjct: 293 TLRNLDLVANLPTKTEESEDEYESFDEQIIEQNQKKNMLRVDS------------KQSLT 340

Query: 148 AEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPED-DERPPEEYDQPWE 206
           +  + S E+  QP  +  T YE EE+           P ++    +  +RP      P  
Sbjct: 341 SGHQSSVESVYQPPSV--TSYEEEEEHYDIYESITETPDDNGYYLNPIQRPANMKTPPPL 398

Query: 207 WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQ 266
             K   S A         D+       +     +   GD   +   +         +S  
Sbjct: 399 PAKPPQSSATPSPTPSRTDIEKLKVKREDLLKMATIIGDPKRNVSLNTA---IRRQASLS 455

Query: 267 FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL--PLENQVWY 324
               + +          R P + SA  P S    S+           P       ++ W+
Sbjct: 456 ECLTQATLTQARLNLAKRSPEKKSATLPHSNSNTSLSSERATRPLPPPPERQSYIDKPWF 515

Query: 325 HGAISRTDAENLLR------LCKEASYLVRNSETSKND-FSLSLKSSQGFMHMKLSRTKE 377
           H  ++R  A  L++        ++  +L+R S T+ N+  +L L       ++ + +  +
Sbjct: 516 H-NVTREQATTLIKEQSTYGNSQDGYFLLRPSTTNVNNPLALVLWYRDRVYNVPVRKRPD 574

Query: 378 HKYVLGQ---NSPPFSSVPEIVHHYASRKLPIKGA 409
           ++Y LG    N   FS+V EIV  Y   +L +   
Sbjct: 575 NRYALGSAKVNEQSFSNVEEIVMFYTREELVLHSG 609


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score =  118 bits (295), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 37/195 (18%), Positives = 72/195 (36%), Gaps = 18/195 (9%)

Query: 232 VGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSA 291
           + QL    +    +          P  ++EDS  +  G   +       +          
Sbjct: 159 LKQLTFDETSTIYEELRPRSKCNSPHWAIEDSRMEGYGSSNATTPLATAQP--------- 209

Query: 292 GNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSE 351
            +P   +       +   E +  A  L +  WYHGA+ R  AE +++  +E  +LVR+  
Sbjct: 210 -SPSEQQEAIALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQ--REGDFLVRDCA 266

Query: 352 TSKNDFSLSLKSSQGFMHMKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLP 405
           +  +++ LS +S    +H  L++      T   +         F +VP+++  Y     P
Sbjct: 267 SQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKP 326

Query: 406 IKGAEHMSLLYPVAI 420
           I  A    + +P   
Sbjct: 327 ISSASGALIQFPCNR 341


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  118 bits (295), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 41/228 (17%), Positives = 76/228 (33%), Gaps = 11/228 (4%)

Query: 195  ERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASP 254
             +P ++  +       +    FA + +V +           +  P+     +     +  
Sbjct: 837  SKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGH 896

Query: 255  LPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDP 314
               P    S    E  ++   +   EE       LS  +          PS         
Sbjct: 897  KDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYC-----VPSLAASISLST 951

Query: 315  ALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNS-ETSKNDFSLSLKSSQGFMHMKLS 373
              PL  + W+HG + R +   LL    +  +LVR +    ++   LS+  +    H  + 
Sbjct: 952  NRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNG-HKHFIVQ 1008

Query: 374  RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
             T E  +      PPF+S+ E++ H    +LP+       L  PV   
Sbjct: 1009 TTGEGNFRF--EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRE 1054


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  118 bits (295), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 52/108 (48%), Gaps = 4/108 (3%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           D +  ++ Q W+HG I RT++  LL+   +  +L+R S  S  DF LS K+     H K+
Sbjct: 460 DQSKTIKEQTWFHGTIPRTESLRLLQQ--DGDFLLRESNNSLGDFVLSAKADGQVRHFKV 517

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             T    Y     +  F +V  ++ H+  ++ P+    +  LL P+  
Sbjct: 518 QVTDNGMYRF--EADQFPTVLNLISHHYQKREPVTKRTNCLLLNPICK 563


>UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RR81_NEMVE
          Length = 473

 Score =  118 bits (294), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 52/301 (17%), Positives = 98/301 (32%), Gaps = 40/301 (13%)

Query: 121 SAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGE 180
                 A  +   ++G    Y++         + E    P   Y  P+   + G      
Sbjct: 211 KYDGGYAKLRSTSDEGVAGLYDSADS----YRNAELPKIPGSGYAVPFARPDSGLDLNPR 266

Query: 181 GAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPS 240
                        D      YD P +    R+            D   P  +  L     
Sbjct: 267 E----------SLDFAAGAMYDNPEDPDDGRLGFYNNPLAGASTDPRLPARMDSLSRDDD 316

Query: 241 LPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPL 300
           +P+     +  +SP        +    + PE                     NP++   L
Sbjct: 317 IPEYHNPETRFSSPPQPTHAPKNLMDDDIPE-------------------YHNPETQFSL 357

Query: 301 SMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLS 360
            +   +P+      +  +  + WYHG ISR +AE LL    E  +LVR S++    + LS
Sbjct: 358 PLSVHAPVASTRSSSF-MRAKDWYHGPISRGEAELLLED--EGDFLVRESKSQPGQYVLS 414

Query: 361 LKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVA 419
               +   H+ L    + +  +      F +V +++  +   ++PI  A   +++ +PV 
Sbjct: 415 GIKDKQARHLLLV-DPQGQ--VRTRDKVFENVDQLISFHLVNQVPIISAGSEVTIKHPVL 471

Query: 420 I 420
            
Sbjct: 472 R 472


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  118 bits (294), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 36/166 (21%), Positives = 70/166 (42%), Gaps = 13/166 (7%)

Query: 256 PEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA 315
           P      S +++     S +     E   L  R        ++    +   P        
Sbjct: 4   PASPRYVSISEYNPKHNSDIPCKGGEAFYLLERTDDWCYVQSETSGSKGYLPSH---LIQ 60

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKS----SQGFMHMK 371
           L L N+ W+HG I R +AENLL+  +  ++L+R SET K  ++L++      ++   H +
Sbjct: 61  LDLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKGSYTLTMIQIKDGTKQISHFR 120

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
           ++   + KY +  ++  F  + +++ HY             +L+YP
Sbjct: 121 INYD-DGKYFI-TSARRFLGLHQLIQHYMQNS----DGLACNLVYP 160


>UniRef50_A9V2C7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2C7_MONBE
          Length = 592

 Score =  118 bits (294), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 51/313 (16%), Positives = 105/313 (33%), Gaps = 32/313 (10%)

Query: 133 ENDGYMEPYEAQKMMAEI---RGSKETATQPLPLYDTPYEPEE-----DGATAEGEGAPW 184
            +  Y E YE +    E    +  ++     L   D P            ++++ E    
Sbjct: 223 PDADYEERYEPEFDEDEQDAAQSDQDADDVALEELDGPSNTSIQDKAAPESSSDSELVVV 282

Query: 185 PRESRLPEDDERPPE---------EYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQL 235
                   +DE             E D   E ++  I         ++        +G  
Sbjct: 283 DSNDAQASEDEADATNDLGESDDWEADLQAELQELEIEGLQVTRPSLLMLHLSCTLIGLS 342

Query: 236 DSSPSLPDGDRDIS--------GPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP 287
               +       +S           S  P               +   S  +     L  
Sbjct: 343 SGVQTPLKLSLPMSALTFSYIFPSISIQPRVIQTKDKRMERQGHRVVFSLTKLTLRALVA 402

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYL 346
            L +    ++  L M       +  D      ++ +YHG ISR +A   L+    + ++L
Sbjct: 403 ALPSSFLFTSLTLKMS-----RKLVDVDESGVDRSYYHGTISREEAVRRLQEVNTDGAFL 457

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
           +R S T K+ +++SL+S+    H++++ T    Y LG++   F S+ +++     + L  
Sbjct: 458 LRLSATQKDAYTISLQSNGEIKHIRVTNTSNGGYALGKSKEEFESIWDLIEAQLDKSLKS 517

Query: 407 KGAEH-MSLLYPV 418
              +  + L++P+
Sbjct: 518 TKGDQAVQLVHPL 530


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  117 bits (293), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 12/112 (10%)

Query: 320 NQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQ----------GFM 368
           ++ W+HG +S  +AE LL    K  S+LVR S++   DF LS+++               
Sbjct: 109 SERWFHGHLSGREAEKLLTEKGKNGSFLVRESQSHPGDFVLSVRTGDDKTDSSDSKPKVT 168

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           H+ +    + KY +G     F S+ ++V HY    +       + L  P+  
Sbjct: 169 HVMIRCQHDLKYDVGG-GEKFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNT 219



 Score =  115 bits (288), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 5/105 (4%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  I+  +AENLL     + S+L R S+++  DF+LS++ +    H+K+  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
           ++  + G     F+++ E+V +Y     +L  K  + + L YP+ 
Sbjct: 61  DYYDLYGGE--KFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  117 bits (293), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 35/197 (17%), Positives = 66/197 (33%), Gaps = 9/197 (4%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
             ++ A        + LP            S          P +  P   +  S +   G
Sbjct: 359 SSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAG 418

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL-------PLENQV 322
              S  S             ++    S    +M  +S       P          L    
Sbjct: 419 MSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMP 478

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG+I+R +AE+LL+  ++  +LVR S     D++L +       H ++   +    + 
Sbjct: 479 WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENK--LT 536

Query: 383 GQNSPPFSSVPEIVHHY 399
             +   F ++ ++V HY
Sbjct: 537 IDDEEYFENLGQLVAHY 553


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score =  117 bits (292), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 33/174 (18%), Positives = 63/174 (36%), Gaps = 18/174 (10%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
               ++  F   E   L   +     +       N   A+  + E   P        + L
Sbjct: 1   MEAVANYPFTPTEPDELGFEKGSTLYIVGMEEDPNWYKARLGNQEGMVP-----ANYISL 55

Query: 319 ENQVWYHGAISRTDAENLLRL---------CKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
               WY    SR +AE  L             + ++++R SE     FS+S+K     +H
Sbjct: 56  YPHPWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVKEGSSVLH 115

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            ++    + KY +  N   F S+  ++ ++  +   I G + + L   V+ +T 
Sbjct: 116 FRIFFDPKGKYYIWTN--KFDSINALIDYHRHQ--TIYGVKALLLRDCVSSKTF 165


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  117 bits (292), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 42/271 (15%), Positives = 82/271 (30%), Gaps = 10/271 (3%)

Query: 153 SKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERI 212
           +  +     P +  P  P + G           +  +     +       Q         
Sbjct: 212 TMHSGGMVPPGHHIPKSPNQHGMLGPSGLQQAAQHHQ--PTAQHGALGSHQSNLMSTSMN 269

Query: 213 SKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEK 272
           S      I   +     P      +   +P   +       P P         Q   P  
Sbjct: 270 SAQLQNHILTSQQQQQQPASAGQGAGVVIPPQQQQQPPQVPPAPHGMSNSMHGQIGLPPP 329

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTD 332
                G  +   +    + G P S+  LS   ++      +    L    W+HG I R +
Sbjct: 330 PSAIGGAFDSNGVSWVGAGGVPTSS--LSPTAAAAAQRRAEVNAKLNAMPWFHGRIKREE 387

Query: 333 AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSV 392
           AENLL+  ++  +LVR S     D++L +  ++   H ++   +    +   +   F ++
Sbjct: 388 AENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKYAENK--LTIDDDEYFDNL 445

Query: 393 PEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            ++V HY              L+  +     
Sbjct: 446 GQLVEHYTLDS----DGLCTKLMKALPKEEF 472


>UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZG2_MONBE
          Length = 1021

 Score =  117 bits (292), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 36/147 (24%), Positives = 59/147 (40%), Gaps = 10/147 (6%)

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLEN------QVWYHGAISRTDAE 334
           +  R PP + AG  KS + L  + S    +  +               W+HG ISR +AE
Sbjct: 779 QPRRPPPSVPAGPRKSEQELKRDASIAWWKEKEEPRGAGKDSYGGFMPWFHGLISRREAE 838

Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
            LLR      +LVR SE     ++LS + S    H  + +  + +Y L   S    S+ E
Sbjct: 839 ELLRPRYIGCFLVRVSENRFG-YTLSYRVSDRCRHYMVEQNTQGQYALVGVSKIADSLNE 897

Query: 395 IVHHYASRKLPIKGAEHMSLLYPVAIR 421
           ++  +    +     +   L  P   +
Sbjct: 898 LIEWFQRNPI---NEDMDMLREPCGQK 921


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score =  117 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 31/129 (24%), Positives = 59/129 (45%), Gaps = 3/129 (2%)

Query: 293 NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
            P      +M P +P          L    WY G ISR +A+++L    + S+LVR++ +
Sbjct: 2   QPSPLHYSTMRPQAPGSLVDPNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS 61

Query: 353 SKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EH 411
            K +++L+L        +K+    + KY   +    F+SV E++++Y    L +      
Sbjct: 62  MKGEYTLTLMKDGCEKLIKICHM-DRKYGFIETDL-FNSVVEMINYYKENSLSMYNKTLD 119

Query: 412 MSLLYPVAI 420
           ++L  P+  
Sbjct: 120 ITLSNPIVR 128



 Score = 77.0 bits (187), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 18/90 (20%), Positives = 37/90 (41%), Gaps = 4/90 (4%)

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R +AE +L+     ++L+R        ++LS+       H  +  T    +        +
Sbjct: 344 RRNAEEMLKGAPSGTFLIR--ARDAGHYALSIACKNIVQHCLIYETSTG-FGFAAPYNIY 400

Query: 390 SSVPEIVHHYASRKLPIKG-AEHMSLLYPV 418
           +++  +V HYA+  L         +L +PV
Sbjct: 401 ATLKSLVEHYANNSLEEHNDTLTTTLRWPV 430


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score =  117 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 32/102 (31%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 319 ENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           E+  WYHG +SR   ENLL+     + S+LVR S +S  DF LS+  +    H ++ R  
Sbjct: 5   EDIFWYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHS 64

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           E  +     +     +  ++ HY + K  +   E +SL  PV
Sbjct: 65  EDAFFSIDENTKIHGLESLIEHYVNTKGILS--EGLSLTVPV 104



 Score = 90.5 bits (222), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 35/154 (22%), Positives = 64/154 (41%), Gaps = 6/154 (3%)

Query: 249 SGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPL 308
           S        P  E +S   +   K+ LS       R        +  + K   +E +  L
Sbjct: 213 SRNTETGAVPLHEAASRGHKDVVKALLSLNAPVNPR-DKDNQLPSHLARKNGFIECAEIL 271

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQG 366
             +  PA       WYHG + R +AE  ++    K+ ++LVR S+ +K +  L+L +   
Sbjct: 272 ENYQCPAPKTHRSYWYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTLINESL 330

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           F +  + +  +  Y+   N P   S+  I+ +Y+
Sbjct: 331 FYNYIIRKQDD--YLFIDNGPYLESLEHIIEYYS 362


>UniRef50_UPI000175FB8C PREDICTED: similar to PTK6 protein tyrosine kinase 6 n=1 Tax=Danio
           rerio RepID=UPI000175FB8C
          Length = 510

 Score =  116 bits (290), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 37/203 (18%), Positives = 73/203 (35%), Gaps = 13/203 (6%)

Query: 226 LPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRL 285
            P      +  ++        + S  ++  P   L  +   ++      LS    E+ R+
Sbjct: 23  SPDKTEAEKPTNTAKQTVNVPNPSRASACEPGSELYKALWSYKARGADELSFQEGEQFRI 82

Query: 286 PPRLSAGNP--KSAKPLSMEPSSPLGE-WTDPALPLENQVWYHGAISRTDAENLLRLCKE 342
             R        K  +  ++     +   +      ++ Q WY G ++R + E LL   + 
Sbjct: 83  CERQGEWWTALKLGRDGAVTGRGFVPNHFLARRQTVKEQPWYFGTLNRFETEILLLAPEN 142

Query: 343 --ASYLVRNSETSKNDFSLSLKSSQG---FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
              ++LVR+SE     + LS+ S        H+K+ + +   + L   S  F S+ ++V 
Sbjct: 143 DVGAFLVRHSEKDNIGYVLSVLSGDRSREVKHIKIHQNQNESFYL-DKSQTFQSLEKLVD 201

Query: 398 HYASRKLPIKGAEHMSLLYPVAI 420
           +Y    L         L  P   
Sbjct: 202 YYWKYSL----DGDSFLKQPCRR 220


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  116 bits (290), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 54/278 (19%), Positives = 93/278 (33%), Gaps = 13/278 (4%)

Query: 150 IRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKK 209
           +  +++     + L D   E  +   TA  E       +   +       E     E + 
Sbjct: 348 LDDAEQLQPGQIELNDLTLEAVQHKLTALEEELMDLARTMGSQQTSLEHLELQLEAEQEG 407

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
            +  +      K          V       +  +  R +         P    S+   + 
Sbjct: 408 VKRGQRIYQFSKRHALEECRQQVALSQGIRARLEVQRVLLKEKLDQLGPRDPPSALSPDP 467

Query: 270 PEKSCLSPG----REEKGRLPPRLSAGNPKSAKPL-SMEPSSPLGEWT--DPALPLENQV 322
                LS        E        SAG P +   L S      +      +   PLE Q 
Sbjct: 468 EASPPLSVTGIAHVSEGRWEGGGGSAGFPDNVLGLFSGNGGGLVLSPVGQEVERPLEQQT 527

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           WYHGAI R + + LL   K+  +LVR S+     + LS+  S    H  + + K++ Y L
Sbjct: 528 WYHGAIPRLEVQQLL--TKDGDFLVRKSQEKPG-YVLSVHWSGACKHFLV-QNKDNMYCL 583

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
              S  F ++P+++  Y + +  +     + L  PV  
Sbjct: 584 DGES--FHTIPQLIQQYQTSQQHVTKKSEVVLRRPVLK 619


>UniRef50_Q5SUW3 Growth factor receptor bound protein 10 n=7 Tax=Euteleostomi
           RepID=Q5SUW3_MOUSE
          Length = 550

 Score =  116 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 40/219 (18%), Positives = 79/219 (36%), Gaps = 11/219 (5%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
               +     +   + L +   + Q    P         + P   + E SL   +  F G
Sbjct: 338 AEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQRKGLPPPFNAPMRSVSENSLV--AMDFSG 395

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
                +    E +        A   +S +   +   SPL   T  A+    Q W+HG IS
Sbjct: 396 QIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNAVIHRTQHWFHGRIS 455

Query: 330 RTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH---KYVLGQ 384
           R ++  +++     +  +L+R+S+++   F L+L   Q   + ++   ++     + L  
Sbjct: 456 REESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFTLDD 515

Query: 385 NSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            +  FS + ++V  Y   K    G     L +      L
Sbjct: 516 GNTKFSDLIQLVDFYQLNK----GVLPCKLKHHCIRVAL 550


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score =  116 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 45/257 (17%), Positives = 94/257 (36%), Gaps = 25/257 (9%)

Query: 187 ESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDL------------PWPPPVGQ 234
           E  L +  E+  ++   PW+ +++ I K   +   V ++                  +  
Sbjct: 444 EMLLSQPVEKNEKQLPSPWQLRRKIILKHKKLPDGVDENSVVIRNEDGAFIHILNGKLFY 503

Query: 235 LDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNP 294
           +  +    D    +      L +P   + +  F    ++ L      +G         + 
Sbjct: 504 MCVTGREMDLRNTVKNGILYLEDPIDNEWNPHFFVLTQNKLLYTDSFQGNNETDTEDDDE 563

Query: 295 KSAKPLSMEPSS---PLGEWTDPALPLENQVWYHGAIS--RTDAENLLR---LCKEASYL 346
           ++      E +     +           +++W+HG +   R +AE+LL+      + ++L
Sbjct: 564 ETGFQRHKEVNKFTFSISLSVPNDELHFSEMWFHGKLGGKRAEAESLLKKYSHLGDGTFL 623

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH---KYVLGQNSPPFSSVPEIVHHYASRK 403
           VR SET   D+SLS        H ++   ++    KY L  ++  F S+  ++ +Y S  
Sbjct: 624 VRESETFVGDYSLSFWRQGKVNHCRIRSKQDKGQTKYYLI-DTNSFDSLYSLITYYRSHP 682

Query: 404 LPIKGAEHMSLLYPVAI 420
           L       + L  PV  
Sbjct: 683 LR-SQEFLIVLKEPVPQ 698



 Score =  110 bits (275), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 30/126 (23%), Positives = 58/126 (46%), Gaps = 8/126 (6%)

Query: 295 KSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETS 353
           +S    S E    L E        E + WY   ++R+ AE +L+    + ++LVR SE  
Sbjct: 679 RSHPLRSQEFLIVLKEPVPQPNKHEGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRPSERG 738

Query: 354 KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS 413
            N +++S ++ +   H ++ +     Y +G  S  F S+ +++ +Y    L     + + 
Sbjct: 739 ANSYAISFRAEKKIKHCRI-KVDGRLYAIG--SVYFESLVDLITYYERHPL----YKKIR 791

Query: 414 LLYPVA 419
           L +PV 
Sbjct: 792 LCHPVN 797


>UniRef50_B8JL24 Novel protein similar to human and mouse SH2 domain containing 4B
           (SH2D4B) n=2 Tax=Danio rerio RepID=B8JL24_DANRE
          Length = 441

 Score =  116 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 45/239 (18%), Positives = 86/239 (35%), Gaps = 32/239 (13%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLP--------- 242
           E +++  E+ D+ WE   E + +  A D ++ +   W     +  S  ++          
Sbjct: 188 EQEQKKSEQRDKAWE---EHLCRCKAADEEMTRKACWARDEYKRQSLRAIEKGHVAGLSG 244

Query: 243 ----DGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK 298
                  R  S    P   P   +      G +++     R  + R     +   P    
Sbjct: 245 HFQKQSQRRHSAFIEPSASPVSSNEVRPKPGLQRAEPPLYRRRQSRRHSTTTTTQPLMDS 304

Query: 299 PLSMEPSSPLGEWTDPALPLENQ---------------VWYHGAISRTDAENLLRLCKEA 343
           P  ++   P           E Q                W+HG ISR D+E LL      
Sbjct: 305 PAWLQTPRPGSRELVILWFNEEQKPKQAGYERNGKAIAPWFHGIISREDSETLLMNAAVG 364

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASR 402
           S+LVR SE     ++LS +++ GF H  +  + ++   LG +    +++ +++  +   
Sbjct: 365 SFLVRVSERIWG-YTLSYRTASGFKHFLIDASGDYYSFLGVDQNRHATLADLIDFHKVS 422


>UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Euteleostomi
           RepID=SH24B_HUMAN
          Length = 431

 Score =  115 bits (288), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 39/211 (18%), Positives = 71/211 (33%), Gaps = 3/211 (1%)

Query: 211 RISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGP 270
           ++ ++ A D +  +         +  S  ++  G              S E  +  +   
Sbjct: 213 QLRRSKAADEERSRRAQRARDEYRHHSLRAIQKGTVAGLSSMFRELGQSHEQEARLYHHL 272

Query: 271 EKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISR 330
               L        R   R      +       +                   W+HG ISR
Sbjct: 273 PDPGLPQPLALPVRTWERPLRPVSRDVIVRWFKEEQLPRRAGFERNTKFIAPWFHGIISR 332

Query: 331 TDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFS 390
            DAE LL    E ++LVR SE     ++LS +  +GF H  +  + +    LG +    +
Sbjct: 333 EDAEALLENMTEGAFLVRVSEKIWG-YTLSYRLQKGFKHFLVDASGDFYSFLGVDPNRHA 391

Query: 391 SVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           ++ ++V  +    + + G E   L  P   R
Sbjct: 392 TLTDLVDFHKEEIITVSGGE--LLQEPCGQR 420


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  115 bits (288), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 5/105 (4%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  I+  +AENLL     + S+L R S+++  DF+LS++ +    H+K+  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
           ++  + G     F+++ E+V +Y     +L  K  + + L YP+ 
Sbjct: 61  DYYDLYGGE--KFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN 103



 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 31/112 (27%), Positives = 52/112 (46%), Gaps = 13/112 (11%)

Query: 320 NQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQ----------GFM 368
           ++ W+HG +S  +AE LL    K  S+LVR S++   DF LS+++               
Sbjct: 109 SERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVT 168

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           H+ + R +E KY +G     F S+ ++V HY    +       + L  P+  
Sbjct: 169 HVMI-RCQELKYDVGG-GERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNT 218


>UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9A03
          Length = 489

 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 70/401 (17%), Positives = 128/401 (31%), Gaps = 38/401 (9%)

Query: 25  SPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKK-KSNWR 83
           + G+     P  S    Q     L  + ++    +RE    +           K +    
Sbjct: 86  AAGNASSTPPAASPHPTQGLMGQLRITSVSGLQDYREAGRPTAGAAHFTAVSPKVEPAVD 145

Query: 84  STTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEA 143
              RLRI  +R R                      EG        + + +N  +      
Sbjct: 146 RFRRLRIGSMRQRRSDL-------------SGCCKEGQLRYLPVDDTISDNQPHW----- 187

Query: 144 QKMMAEIRGSKETATQPLPLYDTP--YEPEEDGATAEGEGAPWPRESRLPEDDE---RPP 198
           Q+    +R         L LYD P    P+     ++ +         +P++        
Sbjct: 188 QRCRLLVRRGGGGEKYVLELYDPPKASSPKLTTQCSDIQEVRRCNRLEMPDNINTFVLKV 247

Query: 199 EEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSS---------PSLPDGDRDIS 249
            +    +E   ++   ++  +IK   +     PV                          
Sbjct: 248 SQGSLIFETDNDQQVSSWTTEIKECINNRHRTPVTSCLCQVLSLLIIRIMLCVTLPPPPP 307

Query: 250 GPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLG 309
            P SP     L  +  +    E+   +   +E G L    S G      P   + S+P  
Sbjct: 308 PPPSPDMMLLLRTAVKKEYKFEEKKQTLNVDELGLLLRSRSGGADLEPLPSPPDVSAPSS 367

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRL---CKEASYLVRNSETSKNDFSLSLKSSQG 366
           +     L  +   W+HG ISR  A  L++         +LVR SET + D+ L+      
Sbjct: 368 QRGSTELSSQAYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQGK 427

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
             H++LS T+  +  +      F SV +++ H+    +P++
Sbjct: 428 AKHLRLSLTEWGQCRVQ--HLRFPSVMDMLSHFRLFPIPLE 466


>UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=1 Tax=Schistosoma
           mansoni RepID=C4QLR4_SCHMA
          Length = 409

 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 42/215 (19%), Positives = 78/215 (36%), Gaps = 11/215 (5%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
            + + A + +  +  +     PV   +    L +     +   S         +      
Sbjct: 202 SKENTALSQNTSMPNNNVTHQPVAFDNFMGHLGNEISSDNQTDSAEYNKPSCGTKKSSAQ 261

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
             ++ L+    ++        AG  KS   +      P  E  +P      + WY G +S
Sbjct: 262 SNQNELTQELSQQPSRKINKVAGV-KSISNIKAPVGLPNFEHLEPV----GEPWYVGKMS 316

Query: 330 RTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPF 389
           R+ AENLLR   +  +LVR S      F LS      + H+ L+     K  +      F
Sbjct: 317 RSQAENLLRY--DGDFLVRASIQQPGQFVLSGLQDGKYRHLLLA-DPNGK--VRTKERVF 371

Query: 390 SSVPEIVHHYASRKLPIKG-AEHMSLLYPVAIRTL 423
            S+  ++ ++     PI+     + L++PV+  T 
Sbjct: 372 DSIQHLIDYHVQNGAPIRSLDSEIRLIFPVSTHTF 406


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score =  115 bits (286), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 42/239 (17%), Positives = 73/239 (30%), Gaps = 38/239 (15%)

Query: 217 AVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLS 276
                    +       Q  S  +  + +RD+  P + +        S    G       
Sbjct: 9   HHHFPTSIPISCSSHSIQSQSRMNTLNANRDLLSPGNDVIVTRTVSPSFYSHGMPSRDNV 68

Query: 277 PGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT--------------------DPAL 316
             +++  R+    S      A+  S E      +                      DP  
Sbjct: 69  FRKDDHVRILGNTSDPAWYRARNASHEEGLVHADCVVRVNGQSYENGIVRMRASGCDPGA 128

Query: 317 PL-------------ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKS 363
                           NQ W+H  ISR + E LLR   + ++LVR S     DF+L +  
Sbjct: 129 ASTASSTSSHHSSVANNQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMAY 188

Query: 364 SQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
                H ++ +T   + +       FS++ ++V HY              L+ P+   T
Sbjct: 189 HGKVEHYRIEQTSGGQ-LTCDKEEYFSNLTQLVSHYKRD----ADGLCHRLVTPIICET 242


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score =  115 bits (286), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 26/141 (18%), Positives = 56/141 (39%), Gaps = 9/141 (6%)

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
              F     + LS  + +  ++               + +       + +    ++   W
Sbjct: 6   KYDFMATGDTELSFRKGDILKILSPEDDWFKAEM---NGQEGYVPQNYIE----IQTPRW 58

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           +    SR+ AE LLR      +++R  ++S  +FS+S++      H K+ R    +Y L 
Sbjct: 59  FQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFKVMRDSRGQYFLW 118

Query: 384 QNSPPFSSVPEIVHHYASRKL 404
             S  F+S+ ++V  Y +  +
Sbjct: 119 --SEKFTSLNKLVDFYRTSSI 137


>UniRef50_B2MW85 Phosphatidylinositol 3-kinase 60 n=1 Tax=Bombyx mori
           RepID=B2MW85_BOMMO
          Length = 577

 Score =  115 bits (286), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 29/112 (25%), Positives = 54/112 (48%), Gaps = 3/112 (2%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
               P   LE   WY G I+R +A   LR  ++ ++LVRN+    + ++L+++       
Sbjct: 186 PQQSPEHSLEAAEWYWGDITRDEANEKLRDTRDGTFLVRNASNKDSGYTLTVRKGGANKL 245

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVAI 420
           +K+    E +Y   +    F SV ++V +Y+   L    +   + LLYP++ 
Sbjct: 246 IKIYHH-EGRYGFREPFE-FKSVVDLVCYYSEYSLATCNSSLDIKLLYPLSR 295



 Score = 89.7 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 25/108 (23%), Positives = 45/108 (41%), Gaps = 4/108 (3%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
           D      +   +    +R  AE LL    + ++L+R + T     +LS+  +    H  +
Sbjct: 463 DEINAHRDMDTWKVNCTRETAEKLLAGKPQGTFLIRPNST--GQLALSIVCNNMVYHCII 520

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVA 419
           ++T E  Y   +    + ++ E+V HYA   L     +    L YPV 
Sbjct: 521 NKT-ECGYGFAEPYNIYETLNELVLHYAGNSLEEHNDQLRTELKYPVN 567


>UniRef50_UPI000186E4D4 hypothetical protein Phum_PHUM500510 n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186E4D4
          Length = 653

 Score =  115 bits (286), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 39/194 (20%), Positives = 71/194 (36%), Gaps = 19/194 (9%)

Query: 243 DGDRDISGPASPLPEPSLEDSSAQFEGPEKSC---LSPGREEKGRLPPRLSAGNPKSAKP 299
            G  D + P+     P  + +     G E      ++   +     P      N  S  P
Sbjct: 388 SGYEDRNPPSPITKPPFSKRALPPLPGVEDDDGEKMALTTDSTPLSPQENKTSNNTSL-P 446

Query: 300 LSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSL 359
              + S    ++      +++  WY G IS   AE +L    + S++VR+S      FSL
Sbjct: 447 FKSKESFASVDFASSIEKVKDCGWYWGPISGKVAEKILSNEPDGSFIVRDSSDDYYIFSL 506

Query: 360 SLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSS------VPEIVHH-------YASRKLPI 406
           + K +    H+++     +      +S  F S      +   V H       +   + P+
Sbjct: 507 TFKLNSIIRHVRIEHDHGNFSF--GSSTRFKSHTIVDFIESAVEHSRSGRYLFFLHRRPV 564

Query: 407 KGAEHMSLLYPVAI 420
            G   + LL+PV+ 
Sbjct: 565 LGPMRVQLLHPVSR 578


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  114 bits (285), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 31/106 (29%), Positives = 48/106 (45%), Gaps = 7/106 (6%)

Query: 317 PLENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
            L  ++WYHG ISR DAE LL        S+LVR+S T+  ++ LSL       H  +SR
Sbjct: 3   DLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISR 62

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             +    + Q+   F S  E++ ++  +          +L  P   
Sbjct: 63  HPDGSVAI-QDGAKFDSPIELIQYHTKK----VDGLITTLKQPCCR 103



 Score = 81.2 bits (198), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 23/91 (25%), Positives = 43/91 (47%), Gaps = 4/91 (4%)

Query: 318 LENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
              Q+W+HGAISR ++E  ++    ++  +LVR   T  N F+L +       H  L   
Sbjct: 158 HRKQLWFHGAISREESEQRMKAFGLRDGLFLVRE-RTEVNSFALCVAVKNDIYHYLLEMN 216

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPI 406
              +  + +N   F ++ ++V HY+     +
Sbjct: 217 TLGQLSI-ENGRKFENLLQVVDHYSRTPDGL 246


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score =  114 bits (285), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 11/134 (8%)

Query: 295 KSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSE-- 351
           KS    S      L E          + W+H  +SR++AE +L+  + + ++L+R SE  
Sbjct: 627 KSNPLKSPTFEQVLAEPVPQQNSHLGKAWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQN 686

Query: 352 TSKND--FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA 409
           T      +++S ++     H ++   +  +Y +G  S  F S+ E+V +Y +  L     
Sbjct: 687 TKAGQKNYAISFRAEGKVKHCRIEVDESGQYCIG--SAIFDSLTELVQYYEANPL----Y 740

Query: 410 EHMSLLYPVAIRTL 423
             M L Y +    L
Sbjct: 741 RRMRLKYAINEDLL 754



 Score =  107 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 9/119 (7%)

Query: 310 EWTDPALPLENQVWYHGAI--SRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQ 365
           E          + W+HG +   R  AE LL   K+   ++LVR S T   D+SLS     
Sbjct: 531 ETLPSTEQHLKEKWFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTTFTGDYSLSFVRDG 590

Query: 366 GFMHMKLSRTKEH---KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
            + H ++    E    ++ L   +  F S+ E++ HY S  L     E + L  PV  +
Sbjct: 591 KYNHCRIHTKSEGGKTRFYLIDQTL-FDSIYELIMHYKSNPLKSPTFEQV-LAEPVPQQ 647


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score =  114 bits (285), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 32/166 (19%), Positives = 61/166 (36%), Gaps = 14/166 (8%)

Query: 259 SLEDSSAQFEGP--EKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
               +   F     E+  L+  + E  ++  R       +      +       +     
Sbjct: 1   MEYVALFDFSPSKEEQDELAFKKGEVLKVIKREDRHWLLA--HQGAKQGLVPENYLKIEK 58

Query: 317 PLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSK--NDFSLSLKSSQGFMHMKLS 373
                 WY G ISR  AE  L     + ++++R+SE++    +FSLS+K      H K+ 
Sbjct: 59  SH---PWYVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKIL 115

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
                KY L      F+S+ ++V ++      +   + + L  P  
Sbjct: 116 TDLAGKYFLWV--VKFTSINDLVDYHKDNS--VSRTQEIVLNEPCV 157


>UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicum
           RepID=Q5DBN4_SCHJA
          Length = 312

 Score =  114 bits (285), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 33/170 (19%), Positives = 62/170 (36%), Gaps = 18/170 (10%)

Query: 263 SSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV 322
           ++  F   E   L   +     +       N   A+  + E   P        + L    
Sbjct: 5   ANYAFSPTEPDELGFEKGSTLCIVGMEEDPNWYKARQGNQEGMVP-----ANYISLCPHP 59

Query: 323 WYHGAISRTDAENLLRL---------CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
           WY    SR +AE  L             + ++++R SE     FS+S+K     +H ++ 
Sbjct: 60  WYIPKCSRREAEARLLETDPNTHRDVQPDGAFVLRQSENDPGHFSISVKEGSSVLHFRIF 119

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
                KY +  N   FSS+  ++ ++  +   I G + + L   V+ +  
Sbjct: 120 FDPSGKYYIWTN--KFSSINALIDYHRHQ--TIYGIKALLLRDCVSSKIF 165


>UniRef50_A9V9Y7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9Y7_MONBE
          Length = 947

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 6/104 (5%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
                 W+HG I+R +AE+LL       +L R SET    ++LS+++     H  +  T+
Sbjct: 833 SGHFHDWFHGVITRREAEDLLAPKPIGCFLTRISETRLG-YTLSVRTRHACKHFVIEETR 891

Query: 377 E--HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           E   +Y+L      F ++  ++ HY          +   L  P 
Sbjct: 892 ESPSRYMLQGRDVYFDTLERLIEHYRGHP---ANDQGDHLTVPC 932


>UniRef50_UPI000052380F PREDICTED: similar to phosphoinositide-3-kinase, regulatory subunit
           3 (p55, gamma) n=1 Tax=Ciona intestinalis
           RepID=UPI000052380F
          Length = 552

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 37/194 (19%), Positives = 75/194 (38%), Gaps = 8/194 (4%)

Query: 234 QLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFE-----GPEKSCLSPGREEKGRLPPR 288
           Q D +  +P    +      P P P                     + P      R    
Sbjct: 68  QTDETGYIPAEYVEYVQTVVPRPAPRERPLLPPVPEVVDEAEVPPVIPPRCGSDSRPQVN 127

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVR 348
            +         +S   +SP       +  L++Q WY G+++R +    L   ++ ++LVR
Sbjct: 128 SNYVPVPINVNVSNGSNSPRPHRPSLSQSLQDQEWYWGSVTREEVNAQLSDEQDGTFLVR 187

Query: 349 NSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG 408
           NS  S  +++L+L+       +++  ++   Y   +    F+SV ++V+HY +  L    
Sbjct: 188 NSANSDREYTLTLRKGGSNKLIRIM-SRNGMYGFAEP-LIFNSVIQLVNHYRNEPLTRYN 245

Query: 409 AE-HMSLLYPVAIR 421
            +  ++L YP   +
Sbjct: 246 PDLDITLRYPAPKQ 259



 Score = 83.1 bits (203), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 21/100 (21%), Positives = 40/100 (40%), Gaps = 3/100 (3%)

Query: 320 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 379
              W+     R +A+ +LR     ++L+R        ++ SL ++    H  + +T +  
Sbjct: 449 ETNWFFPRYGRREADEVLRGTPNGTFLIRERNGPP-PYACSLVANGKVHHCLIEQTDDG- 506

Query: 380 YVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPV 418
           Y   +      ++ ++V HYA   L P        L  PV
Sbjct: 507 YGFAEPFNLHLTLSDLVLHYAHNSLIPHNETLDTKLSIPV 546


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 35/129 (27%), Positives = 58/129 (44%), Gaps = 5/129 (3%)

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSK 354
             K  + +PS         A  L++  WYHG ++R  AE LL     + SYL+R+S  + 
Sbjct: 8   EGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETT 67

Query: 355 NDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMS 413
             +SLS+++     H  +  T    Y        FSS+ + V H+A++ L   +    M 
Sbjct: 68  GLYSLSVRAKDSVKHFHVEYT---GYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMV 124

Query: 414 LLYPVAIRT 422
           L +P   + 
Sbjct: 125 LKHPYPRKV 133


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 44/239 (18%), Positives = 76/239 (31%), Gaps = 15/239 (6%)

Query: 188 SRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD 247
           S  PE  E P   Y      +   I        K     P        +           
Sbjct: 30  SSRPELSEMPVSGY------QGISIHGTLPRKKKTTTGSPVKQWEVNGNVGSLAAPYPGR 83

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
              P SPL    +E+    F    K   +    +      + S        P        
Sbjct: 84  HRLPPSPLIHNIIEE-HQTFCSDRKQSRNSAGMDPTMEYVKFSRDKYILDGPPEKLRREL 142

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
             E    +    +  WYHGAI R  AENL++  ++  +L+R+S +S  ++ L+ +     
Sbjct: 143 EEELKLSSEEPRSHAWYHGAIPRQVAENLVQ--RDGDFLIRDSLSSPGNYVLTCQWKNSP 200

Query: 368 MHMKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            H K+++          +         F S+P +V +Y   + P+       +  P+  
Sbjct: 201 QHFKINKRVVAMNEAYSRVQYLFEKEGFDSIPALVRYYVGNREPVSEVIGAIIFQPINR 259


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 48/115 (41%), Gaps = 2/115 (1%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAEN-LLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
           ++   +     + W+HG I+  +AE  LL   K   +LVR S      + LS+ + +   
Sbjct: 101 KYPLISEDPTTERWFHGKITGKEAEKMLLERGKPDCFLVRESVHRPGSYVLSVLTGEQVA 160

Query: 369 HMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           H+ +       Y +G     FSS+ E++  Y +  +  K    +SL  P      
Sbjct: 161 HIMIHGKPNGMYDVGGGHQ-FSSLKELIDFYTNTPMVEKNGGLVSLKQPFNATRF 214



 Score =  101 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 27/101 (26%), Positives = 51/101 (50%), Gaps = 5/101 (4%)

Query: 322 VWYHGAISRTDAENLLRLCKE-ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
            W+H  ++  +AE LL L     S+L R S ++   F+LS++      H+++  T+E   
Sbjct: 7   RWFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGDEVTHIRIQNTEEFLD 66

Query: 381 VLGQNSPPFSSVPEIVHHYASR--KLPIKGAEHMSLLYPVA 419
           + G     F+++ E+V +Y     +L  K  + + L YP+ 
Sbjct: 67  LYGGE--KFATLSELVTYYMENEGQLREKNGDLIELKYPLI 105


>UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Takifugu rubripes
           RepID=UPI00016E9884
          Length = 843

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 41/270 (15%), Positives = 75/270 (27%), Gaps = 27/270 (10%)

Query: 174 GATAEGEGAPWPRESRLPEDDERPPEEYDQPW---------EWKKERISKAFAVDIKVIK 224
           G  +  +  P  +       DE        P          E K+++ S+         +
Sbjct: 34  GGQSVDDIEPCLQSPNYAHSDEMYTHVGTIPRSQSQKKSCREMKQKKTSRPLPCTPAPGR 93

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
             P   P             +   +          +   S   +      L     E   
Sbjct: 94  PSPLTSPADHCRKPLDHT--EVLWTETDVSDTNSCVRKPSNMTKAASPQDLIEDPHEDNL 151

Query: 285 LPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP--------LENQVWYHGAISRTDAENL 336
                ++G+             P                  L++  WYHG +    AE+L
Sbjct: 152 KGSADTSGDYVKFSKDKFWLEPPSENLKKQLDDELRLSGTNLKSHAWYHGPVPWEVAESL 211

Query: 337 LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT------KEHKYVLGQNSPPFS 390
           +       +L+R+S ++  DF L+    Q  +H  + RT         +         F 
Sbjct: 212 V--VNHGEFLIRDSRSNHGDFVLTCHWQQKTLHFLIRRTVLQSSETYTRVQYSLEEEAFD 269

Query: 391 SVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           S+P +VH Y   K  +       +  P+  
Sbjct: 270 SLPALVHFYVGSKAALTQWSGAQIHRPINR 299


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 36/170 (21%), Positives = 64/170 (37%), Gaps = 9/170 (5%)

Query: 253 SPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT 312
           SPL  P +  SS +F  P  S  S     +    PR +  +P+S    S       G   
Sbjct: 593 SPLISPRVTTSSPRFNFPPSSGGSNSPHSQLSSSPRHNNPSPRSHHNTSPGACRRGG--- 649

Query: 313 DPALPLENQVWYHGAISRTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHM 370
             +     Q W+H  ++R +   L   +   +  +L+R S+     F LS   +Q   H 
Sbjct: 650 INSGIHMTQPWFHSGLTRDETHALFAKQGMVDGMFLIRESQRIPGAFVLSFSHNQKVKHY 709

Query: 371 KLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           +++  ++  Y +      F+ + ++V  Y        G     LL+    
Sbjct: 710 QINMVEDGVYTIDDGGTRFTDLIQLVEFYQLNS----GGLPTRLLHICTK 755


>UniRef50_UPI000186E9A4 SH2 domain-containing protein 4A, putative n=1 Tax=Pediculus
           humanus corporis RepID=UPI000186E9A4
          Length = 472

 Score =  114 bits (284), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 46/226 (20%), Positives = 81/226 (35%), Gaps = 16/226 (7%)

Query: 206 EWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSA 265
           +W+K  + +  +     ++           D+        R+    A    +   E +  
Sbjct: 232 QWEKRVLEERASQIFNKLQRKQLQVVKEAEDAEKRQEILWREQEKKAKEAEQQIREIARR 291

Query: 266 QFEGPEK-SCLSPGREEKGRLPPRLSAGNPKSA------KPLSMEPSSPLGEWTDPALP- 317
             E  ++ SC     E +     R S   P  +      KP S E  +   +  +     
Sbjct: 292 AREEHKRTSCCEIDVETETNQIKRTSTKEPVVSMSVGVIKPRSREAITEWFQTVEVERKA 351

Query: 318 -----LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
                     W+HG ISR +AENLL      S+LVR SE     +++S + S    H  +
Sbjct: 352 GIDDKNHVAPWFHGLISRQEAENLLSDKPVGSFLVRVSEKISG-YAISYRDSDRCKHYLI 410

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
             +  H   LG N     ++ E++  + ++ +   G E   L  P 
Sbjct: 411 DSSNGHYQFLGSNQMTHKTLGELITFHETQAITALGGE--LLRIPC 454


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  114 bits (284), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 7/130 (5%)

Query: 291 AGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNS 350
           + +P        +      +  +    +E + WYHG ISR +A  LL+  K   +LVR S
Sbjct: 485 SSSPCGDMEDEFDDEDVEYDTPEAHAGVEEEPWYHGEISRQEATGLLK--KMGDFLVRYS 542

Query: 351 ETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
              ++ ++L++K      H  +   +E          P+ S+P ++ H+   +LP+    
Sbjct: 543 ADKEH-YTLTVKMEG-IKHFIIQHNEEGFRF---EGDPYPSIPMLIDHHFKNRLPVTRKS 597

Query: 411 HMSLLYPVAI 420
              L  PV  
Sbjct: 598 QAILRQPVKK 607


>UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniota RepID=SH2D3_HUMAN
          Length = 860

 Score =  114 bits (284), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 51/298 (17%), Positives = 94/298 (31%), Gaps = 33/298 (11%)

Query: 149 EIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWK 208
            +R S  + ++   L     EP+   AT +                +        P    
Sbjct: 31  TLRRSSASISRQSHL-----EPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPSI 85

Query: 209 KERISKAFAVDIKVIKDLPWPPPVGQLDSS--PSLPDGDRDISGPASPLPEPSLEDSSAQ 266
           K+  +   A   +     P   P G  D     +  +     +GP    P      S+ +
Sbjct: 86  KKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPSAVE 145

Query: 267 FEGPEKSCLSPGREEKGRLP----PRLSAGNPKSAKP--------------LSMEPSSPL 308
            +   K  +  G  E+ R P       +AG P++                          
Sbjct: 146 VDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELE 205

Query: 309 GEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFM 368
            E    +  L +  WYHG I R  +E L++  +   +L+R+S TS  D+ L+ +     +
Sbjct: 206 EELKLSSTDLRSHAWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQAL 263

Query: 369 HMKLSRT------KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
           H K+++                    F  VP +V ++   +  +       +  PV  
Sbjct: 264 HFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNR 321


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score =  113 bits (283), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 40/231 (17%), Positives = 77/231 (33%), Gaps = 16/231 (6%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP 251
           +++++   EY          I        +V+ +     P+     S        D S  
Sbjct: 177 KNEDKDSHEYYN-------EIPGKGPSADEVLANRMKTEPMEIKRMSNKHLSFSTDHSAS 229

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
               P+         +        +P + +   +  +        A       +      
Sbjct: 230 KVLKPQVGGMFDDPCYINTVPKQDNPSKSQ---ISGKNKEICDLLASKKFYSTTEIQEPK 286

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
                 L+++ WYHG ++R  AE+LL    +  +L+R S TS   + LS        H+ 
Sbjct: 287 LPLYSSLQHEEWYHGKMNRKVAESLLVN--DGDFLIRESTTSACQYVLSGLQGGHPKHLL 344

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP-IKGAEHMSLLYPVAIR 421
           L    + K  +      F SV  ++ ++   +LP I     + L  PV  +
Sbjct: 345 LV-DPDGK--VRTKDHVFESVIHLISYHMENELPIISSGSELYLRKPVRKQ 392


>UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene vav n=1 Tax=Homo
           sapiens RepID=B4DVK9_HUMAN
          Length = 748

 Score =  113 bits (283), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 40/220 (18%), Positives = 71/220 (32%), Gaps = 12/220 (5%)

Query: 208 KKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS---S 264
            + R S       +V                  L    +D       LP+  +       
Sbjct: 450 HRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGL 509

Query: 265 AQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSME-----PSSPLGEWT-DPALPL 318
               G     L     +   L    +  N    +  S       P + +  +   P   L
Sbjct: 510 PPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDL 569

Query: 319 ENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
              +WY G + R  AE++L    + ++LVR       +F++S+K +    H+K+  T E 
Sbjct: 570 SVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIM-TAEG 628

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRKLP-IKGAEHMSLLYP 417
            Y +      F  + E+V  Y    L     +   +L +P
Sbjct: 629 LYRI-TEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 667


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  113 bits (283), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 31/168 (18%), Positives = 64/168 (38%), Gaps = 10/168 (5%)

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSME---PSSPLGEWTDP 314
                    F+      LS    +   +  +       +    +            +   
Sbjct: 10  GPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAE 69

Query: 315 ALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKL 372
              +E++ W+ G ISR++A   L+       ++L+R SE    D+ LS++ +Q   H K+
Sbjct: 70  RETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKI 129

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            R    +  L   +  F S+PE+V+++ ++ L    +  + L  P   
Sbjct: 130 WRRAGGRLHL-NEAVSFLSLPELVNYHRAQSL----SHGLRLAAPCRK 172


>UniRef50_C5J9R9 Src tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C5J9R9_SCHMA
          Length = 565

 Score =  113 bits (283), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 23/201 (11%), Positives = 59/201 (29%), Gaps = 13/201 (6%)

Query: 228 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP 287
               +   + + +         G            +   ++G  +  LS  + +   +  
Sbjct: 84  HMTCLAAQNDAITSAISTVSPGGSGVQARPLVQVRALYSYQGHNQDDLSFQKGDIMFVIS 143

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN--LLRLCKEASY 345
            +S     +    +         +      L   +     I R +A+   LL    + +Y
Sbjct: 144 GMSDAWWFARHSDTGISGYIPSNYVCLNDGLPTSLDAWYNIGRREADRKLLLVGNPQGTY 203

Query: 346 LVRNSETSKNDFSLSLKSSQG------FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
           L+R S +   +++LS++            H ++     +          F ++ ++V++Y
Sbjct: 204 LIRPS-SETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYY 262

Query: 400 ASRKLPIKGAEHMSLLYPVAI 420
                         L  P   
Sbjct: 263 TVHP----DGLCCRLSIPCPR 279


>UniRef50_UPI000069EA62 SH2 domain-containing protein 4A (Protein SH(2)A). n=1 Tax=Xenopus
           (Silurana) tropicalis RepID=UPI000069EA62
          Length = 278

 Score =  113 bits (283), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 3/101 (2%)

Query: 321 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 380
           + W+HG ISR ++E LL      S+L+R SE  +  + LS  S +G  H  +  +     
Sbjct: 170 EPWFHGIISRQESEQLLGSHGHGSFLLRVSEKIQG-YVLSYCSEEGCAHFLIDASATSYS 228

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
            LG +    +++ ++V ++ +  +P  G E   L +P   +
Sbjct: 229 FLGVDQLQHTTLADLVEYHKTEPIPSLGRE--LLRFPCGQK 267


>UniRef50_C3YW40 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YW40_BRAFL
          Length = 756

 Score =  113 bits (283), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 39/229 (17%), Positives = 70/229 (30%), Gaps = 20/229 (8%)

Query: 205 WEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSS 264
           WE  K+    +       I    W     +            + +    P         +
Sbjct: 507 WELSKKSWKFSDEGCPSPIISPEWNLGSYRQRMLMQESQAKEEWARS--PQGPGGKNRVA 564

Query: 265 AQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK---------PLSMEPSSPLGEWTDPA 315
             F G     ++   E          +   + +            S   S     +  P 
Sbjct: 565 MDFTGYRGRVIANPNEAVAVAVEEGQSWRKRHSSGSRALVGSPRNSPLLSPRSSRFISPQ 624

Query: 316 LPLENQVWYHGAISRTDAENL--LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
              + Q W+H  I+R +A N+  ++   +  YLVR S+T    F L+    Q   H ++ 
Sbjct: 625 GVHQTQPWFHHGINREEANNMMHMQGMVDGLYLVRESQTFPGTFVLTFCHDQRVKHYQIQ 684

Query: 374 RT---KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
                 +  Y L +    F  + ++V  Y   +    GA   SL +P  
Sbjct: 685 PNVIDDKTFYSLDEGETKFGDLVQLVEFYQINR----GALPHSLTHPCT 729


>UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona intestinalis
           RepID=UPI00006A5E95
          Length = 572

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/145 (20%), Positives = 60/145 (41%), Gaps = 11/145 (7%)

Query: 287 PRLSAGNPKSAKPLSMEPSSPLGEWTDPAL---PLENQVWYHGAISRTDAENLLRLCKEA 343
           P    GN     P S+E    L      +     + N +WYH  + R +A+ ++    + 
Sbjct: 7   PGGPTGNLVPTFPQSVETQKNLYRDVKSSNNTKEISNCLWYHFKLRREEAQAMVVN--DG 64

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKL----SRTK--EHKYVLGQNSPPFSSVPEIVH 397
            +L+R S +S +D+ L+L+ +   +H K+     R                F S+  ++ 
Sbjct: 65  DFLLRQSLSSVDDYVLTLRWNATVLHFKINKFVQRHDAVNSSTFFVFERAYFDSIYSLIM 124

Query: 398 HYASRKLPIKGAEHMSLLYPVAIRT 422
           ++   ++PI       + +P+  +T
Sbjct: 125 YHMENQIPISVLTGALIQHPITRQT 149


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 8/110 (7%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT- 375
            L++  WYHG + R   E LL   ++  +LVR+S ++  D+ L+     G MH K+ R  
Sbjct: 18  DLKSHAWYHGPLGREAGEALLE--RDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKIIRVV 75

Query: 376 -----KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
                   + +       F +VP ++  +   + PI  A    + +P+  
Sbjct: 76  LRPKQGYSRELFQFEEDRFDNVPALIRFHVGSRRPISQASSAVIFHPITR 125


>UniRef50_UPI0000E45D4F PREDICTED: similar to SH2 domain containing 4B n=2
           Tax=Deuterostomia RepID=UPI0000E45D4F
          Length = 470

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 44/219 (20%), Positives = 72/219 (32%), Gaps = 20/219 (9%)

Query: 202 DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLE 261
            +     K+R  +A     +V +       +  L     L   D+ I  P  PL E    
Sbjct: 251 RESKRADKDRSHRAKIAREEVRRSRILSKDLTHLTIQEELIVMDKRIVPPEKPLEE---- 306

Query: 262 DSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQ 321
                    EK  L   + +  R P     G+    +    E              +   
Sbjct: 307 ---------EKPSLPLRKRQAPRPPKP--TGHKSVVEWFQKEECERQAGLLKDTKEI--A 353

Query: 322 VWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYV 381
            W+HG I+R  AE LL    E  +LVR S      ++LS +  +   H  +  +      
Sbjct: 354 PWFHGIITRQQAEYLLFPKAEGHFLVRVSNRIWG-YALSFRDKERAKHFLIDASGSMYSF 412

Query: 382 LGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            GQ+    +S+ ++V  +    +   G E   L  P   
Sbjct: 413 FGQDQKDHASLEDLVQFHMRMPISEMGKE--VLKTPCVQ 449


>UniRef50_Q13239 Src-like-adapter n=29 Tax=Tetrapoda RepID=SLAP1_HUMAN
          Length = 276

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 40/194 (20%), Positives = 70/194 (36%), Gaps = 21/194 (10%)

Query: 235 LDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNP 294
           + +S        +   P     +       + +  P+ S     R EK R+      G  
Sbjct: 1   MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEG-GWW 59

Query: 295 KSAKPLSMEPSSPLGEWTDPALPLENQVWYHG----AISRTDAENLLR--LCKEASYLVR 348
           K+    +   S   G              YHG     + R  AE LL+    K  S+++R
Sbjct: 60  KAISLSTGRESYIPGICVA--------RVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIR 111

Query: 349 NSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG 408
            SET K  +SLS++  Q   H ++ R   + Y +      F  + ++V+HY+     +  
Sbjct: 112 ESETKKGFYSLSVRHRQ-VKHYRIFRLPNNWYYIS-PRLTFQCLEDLVNHYSE----VAD 165

Query: 409 AEHMSLLYPVAIRT 422
                L  P   ++
Sbjct: 166 GLCCVLTTPCLTQS 179


>UniRef50_C4PYY1 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4PYY1_SCHMA
          Length = 481

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 23/199 (11%), Positives = 59/199 (29%), Gaps = 13/199 (6%)

Query: 230 PPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRL 289
             +   + + +         G            +   ++G  +  LS  + +   +   +
Sbjct: 2   TCLAAQNDAITSAISTVSPGGSGVQARPLVQVRALYSYQGHNQDDLSFQKGDIMFVISGM 61

Query: 290 SAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN--LLRLCKEASYLV 347
           S     +    +         +      L   +     I R +A+   LL    + +YL+
Sbjct: 62  SDAWWFARHSDTGISGYIPSNYVCLNDGLPTSLDAWYNIGRREADRKLLLVGNPKGTYLI 121

Query: 348 RNSETSKNDFSLSLKSSQG------FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           R S +   +++LS++            H ++     +          F ++ ++V++Y  
Sbjct: 122 RPS-SETQNYALSVRHYDSEKNMWVVKHYRIRILDNNGGFFISIRTTFPNIQDLVNYYTV 180

Query: 402 RKLPIKGAEHMSLLYPVAI 420
                       L  P   
Sbjct: 181 HP----DGLCCRLSIPCPR 195


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  113 bits (281), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 27/110 (24%), Positives = 46/110 (41%), Gaps = 6/110 (5%)

Query: 313 DPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNS-ETSKNDFSLSLKSSQGFMHMK 371
               PL  + W+HG + R +   LL    +  +LVR +    ++   LS+  +    H  
Sbjct: 100 STNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNG-HKHFI 156

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +  T E  +      PPF+S+ E++ H    +LP+       L  PV   
Sbjct: 157 VQTTGEGNFRF--EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRE 204


>UniRef50_P05433 P47(GAG-CRK) protein n=1 Tax=Avian sarcoma virus CT10
           RepID=GAGC_AVISC
          Length = 440

 Score =  113 bits (281), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 48/256 (18%), Positives = 81/256 (31%), Gaps = 29/256 (11%)

Query: 187 ESRLPEDDERPPEEYDQPW-EWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGD 245
               PE  E+P  E      E   E   +  A         P            ++    
Sbjct: 108 SPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYYCGAAIGCNC 167

Query: 246 RDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPS 305
              S P  P     L  S A     +       R  +     R +            +  
Sbjct: 168 ATASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPRGAEQPRAGRGAGHRGLRRPAGRGQRV 227

Query: 306 SPLGEWTDPALPLENQV---WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
            P G     A   +++    WY G +SR DA +LL+  +  ++LVR+S +   DF LS+ 
Sbjct: 228 RPAGGAALMAGQFDSEDRGSWYWGRLSRGDAVSLLQGQRHGTFLVRDSGSIPGDFVLSVS 287

Query: 363 SSQGFMHMKLS------------------RTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
            S    H  ++                       ++++G     F S+P ++  Y    L
Sbjct: 288 ESSRVSHYIVNSLGPAGGRRAGGEGPGAPGLNPTRFLIGD--QVFDSLPSLLEFYKIHYL 345

Query: 405 PIKGAEHMSLLYPVAI 420
                +  +L+ PV+ 
Sbjct: 346 -----DTTTLIEPVSR 356


>UniRef50_UPI000179134F PREDICTED: similar to signal transduction protein lnk-realted,
           partial n=1 Tax=Acyrthosiphon pisum RepID=UPI000179134F
          Length = 474

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 44/253 (17%), Positives = 89/253 (35%), Gaps = 32/253 (12%)

Query: 168 YEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLP 227
           Y P +   +  G      +++R  ++ E P E Y   +  K E   +     +   +   
Sbjct: 167 YCPPKSLKSKHGVFCFLIQDARETKEIEMP-ERYANTFVLKDENNVEYIIDALSPEEMRQ 225

Query: 228 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP 287
           W   V            D  I G                 +G   S ++   +     P 
Sbjct: 226 WLATVKYCMRKRDGLHDDISIIGSI---------------DGVLDSSVAHSNDTLLSSPQ 270

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENL---LRLCKEAS 344
                    +   +++         D +  L    W+HG ++R+DA NL   L       
Sbjct: 271 ---------SSTNNLDTILNNDVENDISASLRLYPWFHGMLARSDATNLVSHLGTNGHGM 321

Query: 345 YLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
           +LVR SET K ++ L+        H++++   +    +      F S+ +++ H+ +  +
Sbjct: 322 FLVRQSETRKGEYVLTFNFKGKPKHLRMTLNDQGHCRVQ--HLSFPSIQDMLEHFQTHLI 379

Query: 405 PIK--GAEHMSLL 415
           P++  G   ++L 
Sbjct: 380 PLENGGPGDVTLR 392


>UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DE57
          Length = 699

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 35/197 (17%), Positives = 65/197 (32%), Gaps = 15/197 (7%)

Query: 232 VGQLDSSPSLPDGDRDISGPASPLPEPSLED--SSAQFEGPEKSCLSPGREEKGRLPPRL 289
           + ++ S+          +    P    +      S  F+      + P       L    
Sbjct: 498 MERMYSANPHFVRCIKPNNQKEPGVLDNQVVLLQSTPFDNFLNPSVPP-----PVLGTEE 552

Query: 290 SAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWY----HGAISRTDAENLLRLCKEASY 345
             G     + L    +      T     +++   +    HG ISR +AENLL      S+
Sbjct: 553 QTGEEAKVRKLKRGATLRWFTETQAQKVMQDDGAFPSWLHGMISRREAENLLIDKPLGSF 612

Query: 346 LVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLP 405
           LVR S++    + L+ +      H  +      +YV+       +S+ E+V ++ S  + 
Sbjct: 613 LVRISQSRPG-YILTYRGEGRCRHYMIQVQPNARYVILGEDRAHASLTELVRYHQSVGI- 670

Query: 406 IKGAEHMSLLYPVAIRT 422
                   L  P    T
Sbjct: 671 --QPFMEVLTVPCGQFT 685


>UniRef50_Q7Z7G1-3 Isoform 3 of Cytokine-dependent hematopoietic cell linker n=2
           Tax=Homo sapiens RepID=Q7Z7G1-3
          Length = 391

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 52/334 (15%), Positives = 102/334 (30%), Gaps = 35/334 (10%)

Query: 105 LEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEP-YEAQKMMAEIR---GSKETATQP 160
            +DY DP       E        P +  +   Y +  Y    M   +     +  +  QP
Sbjct: 66  DDDYDDP--ELRMEETWQSIKILPARPIKESEYADTHYFKVAMDTPLPLDTRTSISIGQP 123

Query: 161 LPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDI 220
                T  E  +   + +      P  S+        PE    P +     +S+      
Sbjct: 124 TWNTQTRLERVDKPISKDVRSQNRPPLSQRHTF----PEVQRMPSQISLRDLSEVLEA-- 177

Query: 221 KVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
              K               +    +  ++  +S     +    +    G  + C      
Sbjct: 178 --EKVPHNQRKPESTHLLENQNTQEIPLAISSSSFTTSNHSVQNRDHRGGMQPCSPQ--- 232

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAEN-LLRL 339
              R  P  S    ++  P       P          +++  WY G  SR   E   ++ 
Sbjct: 233 ---RCQPPASCSPHENILPYKYTSWRPPFPKRSDRKDVQHNEWYIGEYSRQAVEEAFMKE 289

Query: 340 CKEASYLVRNSETSKND--FSLSLKSSQGFMHMKLSRTKEHK-YVLGQN---SPPFSSVP 393
            K+ S+LVR+  T   +  + L++       ++K+   + ++ + LG        F SV 
Sbjct: 290 NKDGSFLVRDCSTKSKEEPYVLAVFYENKVYNVKIRFLERNQQFALGTGLRGDEKFDSVE 349

Query: 394 EIVHHYASRKLPIKGA--------EHMSLLYPVA 419
           +I+ HY +  + +           +   L  P+ 
Sbjct: 350 DIIEHYKNFPIILIDGKDKTGVHRKQCHLTQPLP 383


>UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos taurus
           RepID=UPI000179EA7A
          Length = 279

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 33/161 (20%), Positives = 60/161 (37%), Gaps = 9/161 (5%)

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSME-----PSSPLGEWT-DPALP 317
                G     L     +   L    +  N    + +S       P + +  +   P   
Sbjct: 40  LPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNISTNEVGWFPCNRVKPYVHGPPQD 99

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L   +WY G + R  AE++L    + ++LVR       +F++S+K +    H+K+  T E
Sbjct: 100 LSVHLWYAGPMERAGAESILTNRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIM-TAE 158

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLP-IKGAEHMSLLYP 417
             Y +      F  + E+V  Y    L     +   +L +P
Sbjct: 159 GLYRI-TEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFP 198


>UniRef50_Q6PBV3 Zgc:73230 n=2 Tax=Danio rerio RepID=Q6PBV3_DANRE
          Length = 321

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 29/114 (25%), Positives = 59/114 (51%), Gaps = 4/114 (3%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN-SETSKNDFSLSLKSSQG 366
           L    +P+  L++  WY   ISR +   +L    + ++LVR+ S   + +++L+++++  
Sbjct: 17  LQTQREPSDLLQDAEWYWADISREEVNEILHGMPDGAFLVRDASCKVQGEYTLTVRNNGT 76

Query: 367 FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE-HMSLLYPVA 419
              +++   +E K+   +    FSSVPE++  Y +R L        ++L YPV 
Sbjct: 77  NKLIRILH-QEGKFGFSEP-LTFSSVPELISFYRNRSLVHYNTSLDVTLAYPVT 128



 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 27/117 (23%), Positives = 50/117 (42%), Gaps = 3/117 (2%)

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
              + L + +     L  + W+ G ++R  AE LL      ++L+RNS +    ++ S+ 
Sbjct: 199 NFQNTLQKESGCEELLREESWFVGDLARGPAEELLLGKPNGAFLIRNSSSKD-CYACSVV 257

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPV 418
            +    H  +  T+   Y   +      S+ ++V HY+   L     A  + L YPV
Sbjct: 258 VNSQVRHCVIRHTERG-YGFVEPFDLHKSLKDLVLHYSQTSLAQHNQALDVRLAYPV 313


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 35/197 (17%), Positives = 66/197 (33%), Gaps = 9/197 (4%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
             ++ A        + LP            S          P +  P   +  S +   G
Sbjct: 564 SSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAG 623

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL-------PLENQV 322
              S  S             ++    S    +M  +S       P          L    
Sbjct: 624 MSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMP 683

Query: 323 WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 382
           W+HG+I+R +AE+LL+  ++  +LVR S     D++L +       H ++   +    + 
Sbjct: 684 WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENK--LT 741

Query: 383 GQNSPPFSSVPEIVHHY 399
             +   F ++ ++V HY
Sbjct: 742 IDDEEYFENLGQLVAHY 758


>UniRef50_B8A4I5 Novel protein similar to vertebrate lymphocyte cytosolic protein 2
           (SH2 domain containing leukocyte protein of 76kDa)
           (LCP2) n=1 Tax=Danio rerio RepID=B8A4I5_DANRE
          Length = 405

 Score =  112 bits (279), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 67/385 (17%), Positives = 129/385 (33%), Gaps = 61/385 (15%)

Query: 78  KKSNWRSTTRLRIIRLRDRLEPRP-----LAILEDYADPFDVQETGEGSAGASGAPEKVP 132
           KKSN      L +     ++ P P       I +D       +++    +     P +V 
Sbjct: 34  KKSNMSGARFLNMTDKDLKMFPTPHIPFITKICKDINQNNKEKKSLFHRSDHRKPPNQVE 93

Query: 133 ENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEG---EGAPWPRESR 189
              G    +++ +   E               D  YE  ++    +      +  P E+ 
Sbjct: 94  PTSG---GWDSDEFDQED-------------SDNDYEEPDNNEFEDNYICAASGDPAENV 137

Query: 190 LPEDD-ERPPEE--YDQPWEWKKERISKAFAVDIKVIKDLPWPP--------PVGQLDSS 238
             +DD E PP E   + P  ++  +            +    PP        P G L+ S
Sbjct: 138 NSDDDYEAPPSEIPSEIPTHFRAAKPMGDGDYIDTCPRGSARPPQDNSSGRLPRGLLNIS 197

Query: 239 PSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK 298
                 D     P  P  +     +    +  +K   S  + EK      ++     +  
Sbjct: 198 KPPSRPDPSPQRPFIPPNQAKPTPAVPTVDRSKKPGSSKKQTEKPAPKKTITMATKPATL 257

Query: 299 PLSMEPSSPLGEWTDPALPLE-----------NQVWYHGAISRTDAE-NLLRLCKEASYL 346
           P        + ++  P + +            +  WY G ISR +AE +L ++ K+ ++L
Sbjct: 258 PTQRFNMQQMDDFPPPPVEVNEKMEQICSQDMDPQWYVGQISRGEAEVSLRKVKKDGTFL 317

Query: 347 VRNSET--SKNDFSLSLKSSQGFMHMKLSRTKE-HKYVLGQ---NSPPFSSVPEIVHHYA 400
           VR+S     +  ++L +   Q   ++++        Y LG        +SSV E++ H+ 
Sbjct: 318 VRDSSKGCEEQPYTLMVLHQQKVYNIQIRFLGNKDGYSLGTGLNGIENYSSVAEMIMHHM 377

Query: 401 SRKLPIKGAE--------HMSLLYP 417
              L +               L++P
Sbjct: 378 KNPLFLIDGLDRGAGAQNQCCLMHP 402


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 36/220 (16%), Positives = 70/220 (31%), Gaps = 27/220 (12%)

Query: 205 WEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSS 264
             +     ++              PPPV     +     G + I+      P+P      
Sbjct: 11  RAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPG----- 65

Query: 265 AQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLG-------EWTDPALP 317
                     L+  + +   +       +    K  +      L        E       
Sbjct: 66  ---------ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPK 116

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L    W+HG IS  +A   L+  ++  +LVR S     D+ L +   +  +H ++     
Sbjct: 117 LSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRD- 175

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
             ++    +  F ++ ++V HY+  K    GA    L+ P
Sbjct: 176 -GHLTIDEAVFFCNLMDMVEHYSKDK----GAICTKLVRP 210


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 63/303 (20%), Positives = 105/303 (34%), Gaps = 43/303 (14%)

Query: 152 GSKETATQPLPLYDTPYEPEEDGATAE-------GEGAPWPRESRLPEDDERPPEEYDQP 204
             K +A    P   T  E   +G+ A+            +   +    +DE    +  + 
Sbjct: 81  RRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAER--EDELSLVKGSRV 138

Query: 205 WEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSS 264
              +K             I   P    + ++D + +       +   AS           
Sbjct: 139 TVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLH 198

Query: 265 -----AQFEGPEKSCLSPGREEKGRLP--PRLSAGNPK-------------------SAK 298
                  F    +  L+  + E   +   P       K                   S  
Sbjct: 199 VVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDG 258

Query: 299 PLSMEPSSPLGEWTDPALPLE--NQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKN 355
           P      +P   +T P+       + WY+G ++R  AE  L     E  +L+R+SE+S +
Sbjct: 259 PALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPS 318

Query: 356 DFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
           DFS+SLK+S    H K+    ++ Y +GQ    F ++ E+V HY   K PI  +EH   L
Sbjct: 319 DFSVSLKASGKNKHFKVQLV-DNVYCIGQ--RRFHTMDELVEHYK--KAPIFTSEHGEKL 373

Query: 416 YPV 418
           Y V
Sbjct: 374 YLV 376


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 7/111 (6%)

Query: 316 LPLENQVWYHGAISRTDAENLLR-LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR 374
           L +E   WYHG +SR  AE LL    ++ SYL+R+S T   ++SLS+K      H ++  
Sbjct: 7   LEVEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSVKHFQIG- 65

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS--LLYPVAIRTL 423
               +Y  G     F S+ E V H+A++ L I G   +   L +P +   L
Sbjct: 66  WDGKQYQFGMG--VFQSLQEFVEHFANQPL-IGGESGILTALRHPYSRNVL 113


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 26/102 (25%), Positives = 52/102 (50%), Gaps = 2/102 (1%)

Query: 303 EPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLK 362
           + ++ + +      P  ++ W+H  +SR  AENLL   +   +++R S++S  DFS+S++
Sbjct: 12  DSNNSVSKPRHKLNPFSSKRWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVR 71

Query: 363 SSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
                 H K+ R  +  Y L      F S+ ++V +Y +  +
Sbjct: 72  HEDDVQHFKVMRDNKGNYFLWTE--KFPSLNKLVDYYRTNSI 111


>UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio RepID=A2BDR6_DANRE
          Length = 635

 Score =  112 bits (278), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 33/139 (23%), Positives = 56/139 (40%), Gaps = 8/139 (5%)

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLV 347
           + S G  + + P          E    +  L +  WYHG I    +E+L++   E  +L+
Sbjct: 15  KFSKGTHQPSSPPDKLKQELEKELKLSSCNLSSHGWYHGRIPWEVSESLVQQ--EGDFLI 72

Query: 348 RNSETSKNDFSLSLKSSQGFMHMKL------SRTKEHKYVLGQNSPPFSSVPEIVHHYAS 401
           R+S +S  D+ L+ + +Q  +H  +      S     +         F SVP +VH Y  
Sbjct: 73  RDSLSSIGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYVG 132

Query: 402 RKLPIKGAEHMSLLYPVAI 420
            K P+       +  PV  
Sbjct: 133 NKRPLTKKSAAYIYSPVNR 151


>UniRef50_C4QLS5 Tyrosine kinase n=1 Tax=Schistosoma mansoni RepID=C4QLS5_SCHMA
          Length = 801

 Score =  112 bits (278), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 60/411 (14%), Positives = 126/411 (30%), Gaps = 39/411 (9%)

Query: 36  GSLSSAQPHSWMLTPSPLNSHCAHR--EPISSSPQPVA-NGPKQKKKSNWRSTTRLRIIR 92
           GS S+       L      SHC+    E + SS         +Q  +      + +R   
Sbjct: 91  GSKSNLSTPKTSLVNVFAGSHCSESLQETVLSSSYHFPRLTLEQMTRDTRVHHSGVRNSA 150

Query: 93  LRDRLEPR----PLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMA 148
             D L+ +    P+      + P D     + ++              +++ + +  +M 
Sbjct: 151 NSDYLDNKHSVSPIHWCVSSSKPLDEITMQKLNSPHRSNIHVQS--HSHLQQHSSLNIMP 208

Query: 149 EIRGSKETATQPLPLYDTPYEPE---EDGATAEGEGAPWPR---ESRLPEDDERPPEEYD 202
            + G++ + +       +  E     + G     +          +RL   ++       
Sbjct: 209 FLVGNRYSRSGCASATRSAMESPLTIDSGIHKSDKPYRSSVVVDSNRLKNLEQSGGTIST 268

Query: 203 QPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSS-----------PSLPDGDRDISGP 251
               + +   S   +    +        P     +            P +          
Sbjct: 269 AATIFMENGSSDHHSSVGGLSTRYLVHQPYFPSSAGSSSRLSLGSVGPCINSKKIYPLTQ 328

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
            +         +   +E      +S  + ++ R+     +         S +       +
Sbjct: 329 ENSHNSEYYHVAIFDYEAHTSEEVSARKGDQLRVLDLSDSEWWLVEH--SGQVGYIPSSY 386

Query: 312 TDPALPLENQVWYHGAISRTDAENLLRLCKE--ASYLVRNSETSKNDFSLSLK-----SS 364
              A  +E + WY  +ISR D+E LL L      ++LVR SET+    SLS++       
Sbjct: 387 LAQANSVEAEDWYFRSISRKDSERLLLLKGNIRGTFLVRASETTNGALSLSVRDTEQQRG 446

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLL 415
           +   H K+ ++ E   V       F  +  +V HY+++           L 
Sbjct: 447 ETVKHYKIKQSSETNDVYITTKQVFPDLKSLVIHYSNQ----ADGLCCCLT 493


>UniRef50_Q9D7V1 SH2 domain-containing protein 4A n=10 Tax=Tetrapoda
           RepID=SH24A_MOUSE
          Length = 421

 Score =  112 bits (278), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 49/267 (18%), Positives = 88/267 (32%), Gaps = 24/267 (8%)

Query: 175 ATAEGEGAPWPRESRLPEDD---ERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPP 231
           A +E      PR     +DD    +P +E D   E K+    K   +     +D  W   
Sbjct: 148 AASEEASGQGPRAIPTRKDDKAQTKPVKEKDH-EEMKQTEDEKTKQIYKSWKEDSEWQAS 206

Query: 232 VGQL-------DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGR 284
           + +         S       D           +      +   +          +  +  
Sbjct: 207 LRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPLPPKPQFLQPL 266

Query: 285 LPPRLSAGNPKSAKP-LSMEPSSPLGEWTDPALPLENQV---------WYHGAISRTDAE 334
             P  S GN    +  +S      +  + +  LP              W+HG ++   A 
Sbjct: 267 GIPPKSLGNQGVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGILTLKKAN 326

Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
            LL      S+L+R SE  K  ++LS  S +G  H  +  +      LG +    +++ +
Sbjct: 327 ELLSTGVPGSFLIRVSEKIKG-YALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLAD 385

Query: 395 IVHHYASRKLPIKGAEHMSLLYPVAIR 421
           +V ++    +   G E   LLYP   +
Sbjct: 386 LVEYHKEEPITSLGKE--LLLYPCGQQ 410


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  112 bits (278), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 44/292 (15%), Positives = 95/292 (32%), Gaps = 43/292 (14%)

Query: 171 EEDGATAEGEGAPWPRESRLPEDDE-------RPPEEYDQPWEWKKERISKAFAVDIKVI 223
             + + +    +P     +  +  E       +   +  QP E    + S+   ++    
Sbjct: 122 PSNNSPSRTVESPSMARRQAADPSEAIGTAVVKYNYQAQQPDELSLVKGSRILILEKSND 181

Query: 224 KDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEP----SLEDSSAQFEGPEKSCLSPGR 279
                           +    + D                +  +   F       LS  +
Sbjct: 182 GWWRGQSGNVAGWFPSNYTQEEGDADDTLHTYAMAENVLDIVVALYSFSSTNDQELSFEK 241

Query: 280 EEKGRLPPRLSA-GNPKSAKPLSMEPSSPLGEWT-------------------------- 312
            ++  +  R  +      A+    +       +                           
Sbjct: 242 GDRLEILDRPPSDPEWYKARNAQGQVGLVPRNYLQELSEYLTQPFLDRKQEPMERSQVAM 301

Query: 313 DPALPLENQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
                L ++ WY+G+I+R   +NLL +   +  +L+R+SET+  D+S+SLK+     H +
Sbjct: 302 GDKPHLVDKPWYYGSITRYMCDNLLNQRGHDGDFLIRDSETNVGDYSVSLKAPGRNKHFR 361

Query: 372 LSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL-PIKGAEHMSLLYPVAIRT 422
           +   +   Y +GQ    F ++ ++V HY    +   K  E + L+ P+   T
Sbjct: 362 V-HVEGALYCIGQ--RKFHTLDQLVDHYQRAPIYTNKQGEKLYLVRPLPKPT 410


>UniRef50_B7PK27 Putative uncharacterized protein n=1 Tax=Ixodes scapularis
           RepID=B7PK27_IXOSC
          Length = 569

 Score =  111 bits (277), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 95/478 (19%), Positives = 149/478 (31%), Gaps = 58/478 (12%)

Query: 4   EGGPVRSAPCRTGTLEGSRQGSPGHRKRASPKGSLSSAQPHSWMLT-----PSPLNSHCA 58
           + G  +  P +  +  GS Q     +  A+P+GS S A P              +N    
Sbjct: 92  QDGCPKPPPHQGSSGSGSSQPGASQQPMAAPRGSSSGAVPVPAARGQPGHGKVNINCLKG 151

Query: 59  HREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETG 118
              P  S   P+ +G      S   S         ++   P+     +  +      +  
Sbjct: 152 KLWPNGSRRHPIKSGVTYIHPSIQPSMPSADKAIYQNHPLPQSPGADKSASQVAMAVKRS 211

Query: 119 EGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR---GSKETATQPLPLYDTPYEPEEDGA 175
             + G    P +      +    E + M        G + T++  +    +         
Sbjct: 212 IHAGGIKVLPSEPVRRTRHNHRREGEPMALAPVLLNGFQATSSDNVSSSSSSDNSPRKPD 271

Query: 176 TAEGEGAPWPRES---------RLPEDDERPPEEYDQPWEWKK-ERISKAFAVDIKVIKD 225
              G  AP    +         + P  D RP  +YD+PW+  + +       V    +  
Sbjct: 272 EKRGRHAPPLPHALGALHNGAHQSPSSDTRPEGDYDRPWDLPRLKHTESPPQVPGHRVAK 331

Query: 226 LPWPPPVGQLDSSPSLPDGDRDIS-----GPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
            P      Q +        D          PA             Q +   +   S    
Sbjct: 332 PPALHSPTQANGPTPSSSADAATDVNADRRPADKRMLACRSAFQPQLQPQPQPLHSQSPS 391

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHG-------AISRTDA 333
              R                +  P    G        L +    +G        +SR+ A
Sbjct: 392 SDTRPEGDYDRPWDLPRLKHTESPPQVPGHRVAKPPALHSPTQANGVNAGDEVTVSRSCA 451

Query: 334 ENLLRLCKEA---------------SYLVRNSETSKNDFSLSLKSSQG------------ 366
             L   CK                  ++V  S        L+     G            
Sbjct: 452 GCLYSNCKLVQGASLCEPSSFVKCSCFIVCISNYCILFILLNYVHRDGASGTCQAQWSAR 511

Query: 367 -FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
            FMHMK+   ++ K++LGQ S PF S+PE++HHY+  KLPIKGAEHMSLLYPV  + L
Sbjct: 512 GFMHMKIVHNEDGKFILGQFSKPFESIPEMIHHYSVNKLPIKGAEHMSLLYPVIDQLL 569


>UniRef50_Q4H2S5 Suppressor of cytokine signaling n=1 Tax=Ciona intestinalis
           RepID=Q4H2S5_CIOIN
          Length = 406

 Score =  111 bits (277), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 38/212 (17%), Positives = 72/212 (33%), Gaps = 13/212 (6%)

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREE 281
             +      P   L   PS          P+    E ++   S       +S        
Sbjct: 153 TSQGTSENSPNENLYQLPSNDTHTNHSGKPSQLQEEDTVVPDSTDVYQTPESLDHGIMGA 212

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK 341
                         +   L + P+      T+    L  Q WY G ++R++AE+ L    
Sbjct: 213 TAAPVSPDVNHTFHTLTSLHVPPTMRKNTLTNEFKKLAQQGWYWGPLTRSEAEDKLNETP 272

Query: 342 EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNS-PPFSSVPEIVH--- 397
             S+LVR+S   +   SLS +S    +H ++  +  +      N    + SV +++    
Sbjct: 273 NGSFLVRDSSDERYLLSLSFRSFGRTLHTRIEHSSGNFSFYENNRMQSYDSVVDLIMDSV 332

Query: 398 ---------HYASRKLPIKGAEHMSLLYPVAI 420
                     Y+  + P+     + L++PV+ 
Sbjct: 333 RDSQEAGIFCYSRTRDPLATTYPVRLIHPVSR 364


>UniRef50_UPI000180CF27 PREDICTED: similar to phospholipase C gamma n=1 Tax=Ciona
           intestinalis RepID=UPI000180CF27
          Length = 1298

 Score =  111 bits (277), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 34/159 (21%), Positives = 60/159 (37%), Gaps = 9/159 (5%)

Query: 267 FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHG 326
           F   E + L    E + +     ++        +    ++     +D       + WYHG
Sbjct: 516 FVLTEDNKLVYTEERQTQPHDDTTS----EDGSIDESANNDRRGSSDTTELHYAEKWYHG 571

Query: 327 AISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL--SRTKEHKYVL 382
            + R +A+ LLR    K+ S++VR S T   + +LS        H ++   +   H Y  
Sbjct: 572 QMGRDEADQLLRDYNGKDGSFMVRESATFIGNCTLSFMYHGRVTHCRIHSQQNNGHTYFY 631

Query: 383 GQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPVAI 420
             ++  F S+  +V HY    L        + L  PV  
Sbjct: 632 LVHALLFDSLYSLVWHYQRYPLRNAKMNFELLLTEPVPQ 670



 Score = 93.9 bits (231), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 28/131 (21%), Positives = 54/131 (41%), Gaps = 11/131 (8%)

Query: 295 KSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETS 353
              +   M     L E         N+ WYH +++RTDAEN+L     + ++LVR   + 
Sbjct: 651 YPLRNAKMNFELLLTEPVPQPNAHANKEWYHDSMTRTDAENVLMRIPRDGAFLVRKCRSD 710

Query: 354 K---NDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
                 F++S ++     H ++ + +   +V+G     F ++ +++  Y    L      
Sbjct: 711 DPSVTSFAISFRADGKIKHCRIKQ-ESRLFVIGN--ATFETLCDVISFYEKNPL----YR 763

Query: 411 HMSLLYPVAIR 421
            M L +P    
Sbjct: 764 KMKLKHPATKE 774


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score =  111 bits (277), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 51/288 (17%), Positives = 100/288 (34%), Gaps = 17/288 (5%)

Query: 140 PYEAQKMMAEIRGSKETATQPLPLYDTP--YEPEEDGATAEGEGAPWPRESRLPEDDE-- 195
            ++  +++    G  +     L L+D P   +P+   A +  +         +P++    
Sbjct: 193 RWQRCRLVLRRAGMPDGEEYVLELFDPPKGSKPKLRAACSAIQEVRRCTRLEMPDNLHTF 252

Query: 196 --RPPEEYDQPWEWKKERISKA------FAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRD 247
             +     D  +E   E    +      F    +      WP          + P     
Sbjct: 253 VLKVTNATDVLFEAGDEHQLSSYATDVLFEAGDEQPFKPGWPRSGKLAKLESACPQMLCP 312

Query: 248 ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSP 307
              PASP+    +  + +  +        P          ++S    +     +M    P
Sbjct: 313 ALIPASPIHAGQMWVTLSSCQAGTPIPQPPALLPAPTPQAKVSTRGHQEQGRGAMPGGPP 372

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCK---EASYLVRNSETSKNDFSLSLKSS 364
                     L +  W+HG ISR  A  L++L        +LVR SET + ++ L+    
Sbjct: 373 EAAGPKMEQFLSSCPWFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLTFNFQ 432

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHM 412
               H++LS T+  +  +      FSS+ E++HH+    +P++     
Sbjct: 433 GRAKHLRLSLTERGQCRVQ--HLRFSSITEMLHHFHRYPIPLECGATC 478


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 48/246 (19%), Positives = 88/246 (35%), Gaps = 38/246 (15%)

Query: 207 WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSL----PDGDRDISGPASPLPEPSLED 262
            +K            +    P       +D +  +    PD    +    +         
Sbjct: 91  MEKCSDGWWRGSYNGLSGWFPSNYVTEDVDGTMRVDSVNPDKLASVGHNNNSSQVLQTVQ 150

Query: 263 SSAQFEGPEKSCLSPGREEKGRLP--PRLSAGNPKSAKP--------------------- 299
           +   F       L+  + E   +   P       K  K                      
Sbjct: 151 ALYHFSSGNVEELNFNKYELMDVLEKPENDPEWWKCRKENGQVGLVPKNYVTVVQKTHKE 210

Query: 300 LSMEPSSPLGEWTDPALPLE--NQVWYHGAISRTDAENLL-RLCKEASYLVRNSETSKND 356
           L +    P      P++  +   + WY+G ++R  AE +L +   +  +L+R+SE+  ND
Sbjct: 211 LGISGPHPSNYDIKPSMDGKFGGKQWYYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPND 270

Query: 357 FSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEH---MS 413
           FS+SLK+     H K+    +  + +GQ    FS++ ++V HY   K PI  +EH   + 
Sbjct: 271 FSISLKALYKNKHFKVL-LNDGFFCIGQ--RKFSTMEDLVEHYK--KAPIFTSEHGDKLY 325

Query: 414 LLYPVA 419
           L+ P+ 
Sbjct: 326 LIKPLT 331


>UniRef50_UPI000180B456 PREDICTED: similar to SH2 domain-containing protein 4B n=1
           Tax=Ciona intestinalis RepID=UPI000180B456
          Length = 537

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 49/274 (17%), Positives = 92/274 (33%), Gaps = 14/274 (5%)

Query: 149 EIRGSKETATQPLPLYDTPYEPEED-GATAEGEGAPWPRES----RLPEDDERPPEEYDQ 203
             +   + AT      D   +P+   G  +  +      ES      P+ D    EE++Q
Sbjct: 239 RPKTPPKVATPKTSPKDERKQPKSPKGQRSVEKETENIYESVDDVTKPQVDLVSNEEWNQ 298

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISG-------PASPLP 256
                KE   K      +   ++     +    +   +    +  +          S L 
Sbjct: 299 QLRRFKEEDEKRKIRARRASIEVKRQSLIAVNRNKSKIKSLRQKFAKLGSFDNEKESKLE 358

Query: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSS-PLGEWTDPA 315
           +P+L    A  +       S             + G P S   +           + D  
Sbjct: 359 KPTLPPKLAVIDTVVPPITSLRARSPVVTSRLSTTGKPNSRNDVKRWFEDKQTSAFVDDR 418

Query: 316 LPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
             +    W+HG ISR+DAE+LL    E  +L+R S+     ++LS K+     H  +  +
Sbjct: 419 GDVIIPTWFHGIISRSDAESLLCSRPERDFLIRLSDKIWG-YALSYKAEDRVKHFLIDAS 477

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA 409
           +   +  G +     S+ E+V ++    +   G 
Sbjct: 478 EGSYHFFGNDQIRHESLAELVEYHKEEDITYNGE 511


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 44/198 (22%), Positives = 68/198 (34%), Gaps = 13/198 (6%)

Query: 231 PVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKG--RLPPR 288
            + Q  +  ++           S L      D            L       G  R    
Sbjct: 184 CLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQP 243

Query: 289 LSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQV-----WYHGAISRTDAENLLRLCKEA 343
           L +       P +++P +     +  +LP   Q       YHG +SR  AE+LL   K+ 
Sbjct: 244 LGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL--VKDG 301

Query: 344 SYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRK 403
            +LVR S TS   + LS        H+ L    E K  +      F +V  ++ ++    
Sbjct: 302 DFLVRESATSPGQYVLSGLQGGQAKHLLLV-DPEGK--VRTKDHVFDNVGHLIRYHMDNS 358

Query: 404 LP-IKGAEHMSLLYPVAI 420
           LP I     +SL  PV  
Sbjct: 359 LPIISSGSEVSLKQPVRK 376


>UniRef50_Q59F39 IL2-inducible T-cell kinase variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59F39_HUMAN
          Length = 376

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 36/209 (17%), Positives = 73/209 (34%), Gaps = 14/209 (6%)

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
           P  W   +      ++        + P              D   +      PE ++  +
Sbjct: 167 PNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPED---NRRPLWEPEETVVIA 223

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPA-LPLENQV 322
              ++  +   L+  R E+  L         +       E   P     + +   LE   
Sbjct: 224 LYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYE 283

Query: 323 WYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGF-------MHMKLSR 374
           WY+ +ISR  AE LL    KE +++VR+S T+   +++S+ +            H  +  
Sbjct: 284 WYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKE 342

Query: 375 TKEH-KYVLGQNSPPFSSVPEIVHHYASR 402
           T ++ K         F S+P +++++   
Sbjct: 343 TNDNPKRYYVAEKYVFDSIPLLINYHQHN 371


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 26/113 (23%), Positives = 53/113 (46%), Gaps = 6/113 (5%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSL--SLKSSQGF 367
           +       ++   +YHG I RTD E LL+  KE  +L+R +E +  +  L  S++ +   
Sbjct: 11  DSVSITDDVKGADYYHGLIPRTDIEPLLK--KEGDFLLRKTELTPGEIVLAISVRHNNAV 68

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            H  +++ ++  +    +     SV +++ +Y S K P+  +    L  P+  
Sbjct: 69  RHFMVNQDQDGSFYCEHHHEK--SVSDLIQYYKSTKEPLSASSQARLRRPIER 119


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score =  111 bits (276), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 45/271 (16%), Positives = 89/271 (32%), Gaps = 29/271 (10%)

Query: 171 EEDGATAEGEGAPWPRESRLP----------EDDERPPEEYDQPW-------EWKKERIS 213
             +     G    +  ESRL            + +R P  Y   +        ++   + 
Sbjct: 79  PPESEWYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSYYGRTGINHFRITAVC 138

Query: 214 KAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQF-EGPEK 272
             F +  +    L          S     +       P  P+ +     +   + + PE 
Sbjct: 139 GDFYIGGRQFISLSDLVGYYTSCSDLLKRERLAIPVAPPEPVNDKKRVVAILPYTKMPET 198

Query: 273 SCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL----PLENQVWYHGAI 328
             LS  + +   +   +  G        + E      E  D       P     W+H   
Sbjct: 199 DELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWFHPNC 258

Query: 329 SRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPP 388
           ++ +A ++L      S+LVR S+ S  D+SL    +      ++ + K  +Y++G     
Sbjct: 259 TKNEAVDMLVKAGPGSFLVRPSDNSPGDYSLFFHINNQIQRFRIEK-KGVRYLMG--GRT 315

Query: 389 FSSVPEIVHHYASRKLPIKGAEHMSLLYPVA 419
           F  +  +++ Y   ++     E  SL +PV 
Sbjct: 316 FECLDAVINRYRKEQIV----EGHSLNHPVV 342



 Score = 95.1 bits (234), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 32/125 (25%), Positives = 47/125 (37%), Gaps = 7/125 (5%)

Query: 296 SAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSK 354
                  +    L       +      WYHG + R  AE+ LR   K  SYLVR S+   
Sbjct: 57  ELDHDEFDGPHMLNGERPAIIAPPESEWYHGRLDRYSAESRLRGSSKLGSYLVRESDRKP 116

Query: 355 NDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSL 414
             + LS     G  H +++      Y+       F S+ ++V +Y S    +K      L
Sbjct: 117 GSYVLSYYGRTGINHFRITAVCGDFYI---GGRQFISLSDLVGYYTSCSDLLKRE---RL 170

Query: 415 LYPVA 419
             PVA
Sbjct: 171 AIPVA 175


>UniRef50_A9UNJ0 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UNJ0_MONBE
          Length = 931

 Score =  111 bits (276), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 40/218 (18%), Positives = 79/218 (36%), Gaps = 12/218 (5%)

Query: 192 EDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGP 251
           E    P  E   P  W+    S    V +           +  +D    +      ++ P
Sbjct: 488 ESVSDPAGEDGYPHRWRLMDTSGKKPVPLLTFGSYHEATKMRWMDM---IRGKMLAVATP 544

Query: 252 ASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEW 311
           ASP P      +      P  +  SP           + +G  +         S P+   
Sbjct: 545 ASPPP----LRARMSLRAPNGASSSPKPRRSLSESAAVGSGLARPPSSPRPVLSPPIVGP 600

Query: 312 TDPALPLENQVWYH--GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
             P   + +   +   GA S +++E  L+   + ++LVR S + +  +SL++       H
Sbjct: 601 RVPRNSVADDEAWFLPGAASLSESE--LKDLPDGTFLVRESTSRQGSYSLTVVFQNEVKH 658

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK 407
           +K+ R    +Y L +++  F +V ++V  +  + L   
Sbjct: 659 IKILRDGT-QYRLTEHAEGFDTVQQLVAFFQRQNLGTY 695


>UniRef50_B0XFC9 Phosphatidylinositol 3-kinase regulatory subunit n=3 Tax=Culicini
           RepID=B0XFC9_CULQU
          Length = 872

 Score =  111 bits (276), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 44/224 (19%), Positives = 80/224 (35%), Gaps = 9/224 (4%)

Query: 201 YDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE--- 257
           Y   W+ K        AV  +               S  S        +    P P    
Sbjct: 364 YKLDWKEKLPEFLSTPAVPPRKTSRSTGVGSASSSLSLSSTSSSSTSTTVTQQPQPSAAG 423

Query: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
            SL+  SA       + + P     G +    +     + +   M  +  +G+   PA  
Sbjct: 424 GSLKKPSAIQSPAGPTAVIPSPLADGAVGTYNNTNGVDAVR--GMRGTMAVGDADTPA-D 480

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           L    WY G ISR +A+  +   ++ S+LVR++ +   +++L+LK       +K+     
Sbjct: 481 LREAEWYWGRISRDEAKEKMTDVQDGSFLVRDATSGGGEYTLTLKKDGTDRVIKIYHC-N 539

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVAI 420
            +Y         +SV E++  Y    L        + L+YP++ 
Sbjct: 540 GRYGF-TKECNHASVVELIAFYKRESLKEYNTILDIKLMYPISR 582



 Score = 82.7 bits (202), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 27/144 (18%), Positives = 50/144 (34%), Gaps = 17/144 (11%)

Query: 275 LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAE 334
           L   +   G +   L+ GN  +A   ++                           R  AE
Sbjct: 735 LHRLKFTDGEIKQMLADGNWSAAPSSNLPHEDETTWLKIAYN-------------RQQAE 781

Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
             L      ++L+R        F+LS+  ++   H  + +T+   Y   +    + S+ +
Sbjct: 782 QELAGRPTGTFLIR--GRVGGQFALSITCNETVNHCIIHQTERG-YGFAEPYNIYGSLKQ 838

Query: 395 IVHHYASRKLPIKG-AEHMSLLYP 417
           +V HYA+  L         +L YP
Sbjct: 839 LVLHYANNSLEEHNDTLQTTLKYP 862


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score =  111 bits (276), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 27/102 (26%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 320 NQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH 378
            + W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    + 
Sbjct: 324 RRKWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDF 383

Query: 379 KYVLGQNSPPFSSVPEIVHHYASRK-LPIKGAEHMSLLYPVA 419
             + G     F+++PE+V +Y     L  K  + + L  P+ 
Sbjct: 384 FDLYGGE--KFATLPELVQYYMENGELKEKNGQAIELKQPLI 423


>UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID=Q7PSB5_ANOGA
          Length = 940

 Score =  111 bits (276), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 24/117 (20%), Positives = 50/117 (42%), Gaps = 8/117 (6%)

Query: 310 EWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
           E +  +  L +  WYHG I R  AE +++  KE  +LVR+  +   ++ L+ ++    +H
Sbjct: 227 ELSLDSRDLRSHAWYHGPIPRQRAEEIVQ--KEGDFLVRDCVSQPGNYVLTCRTKGPTLH 284

Query: 370 MKLSR------TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
             +++      T   +         + +VP+++  Y      I  A    + +P   
Sbjct: 285 FVINKLLLQPETVYERVQYQFEDDAYDTVPDLITFYVGSGKSISVASGARIQFPCNR 341


>UniRef50_UPI0000E818A6 PREDICTED: similar to Myosin-VIIa n=3 Tax=Gallus gallus
           RepID=UPI0000E818A6
          Length = 918

 Score =  110 bits (275), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 44/265 (16%), Positives = 81/265 (30%), Gaps = 35/265 (13%)

Query: 184 WPRESRLPEDDERPPEEYDQPWEWKKERISK-AFAVDIKVIKDLPWPPPVGQLDSSPSLP 242
             R+S L    E   +   Q  E ++ER  + A   + +    LP P P  +    P   
Sbjct: 543 RCRKSYLSLLAELRAQAQRQQEEAERERSRQLAMEAEAQKTISLPVPVPRKRR---PLPC 599

Query: 243 DGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSM 302
              +  +      P P       +F              +         G     K L  
Sbjct: 600 PRPQTATDTLLQPPVPRPRSKLTEFTPF--DNFLHPSGPRPVTGTEEQTGEKAKMKQLKR 657

Query: 303 EPSSPLGEWTDPALPLENQVWY----HGAISR---------------------TDAENLL 337
             +      T     +++   +    HG ISR                      +AENLL
Sbjct: 658 GATLRWFRETQAQKVMQDDGAFPSWLHGMISRRNGNGMQNLSLFDCELQTIKRKEAENLL 717

Query: 338 RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVH 397
                  +LVR S++    ++L+ +      H  +      +YV+       +S+ E+V 
Sbjct: 718 IDKPLGCFLVRISQSRPG-YTLTYRGEGRCRHYMIEMQPNARYVILGEDRAHASLTELVR 776

Query: 398 HYASRKLPIKGAEHMSLLYPVAIRT 422
           ++ +  +         L  P   ++
Sbjct: 777 YHQTVGI---QPFMEILTVPCGQKS 798


>UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D8F4
          Length = 792

 Score =  110 bits (275), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 28/134 (20%), Positives = 53/134 (39%), Gaps = 8/134 (5%)

Query: 293 NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSET 352
           NP++    +    +   E +  A  L +  WYHG+I RT AE +L    +  +LVR+  +
Sbjct: 44  NPENGLDPAQLRKALEWELSLDARDLRSHAWYHGSIPRTRAEEILES--DGDFLVRDCTS 101

Query: 353 SKNDFSLSLKSSQGFMHMKLSRT---KEHKY---VLGQNSPPFSSVPEIVHHYASRKLPI 406
              +F LS K     +H  +++     +  Y           + +V +++ +Y      I
Sbjct: 102 QPGNFVLSTKCKGQNLHFVINKVVLQPDTVYERIQFQFEDEAYDTVSDLITYYVGSGKVI 161

Query: 407 KGAEHMSLLYPVAI 420
                  +  P   
Sbjct: 162 SSLSGARIQNPKNR 175


>UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2
           domain-containing-transforming protein C3) (Neuronal
           Shc) (N-Shc) (Protein Rai). n=15 Tax=Euteleostomi
           RepID=UPI0000ECC29C
          Length = 582

 Score =  110 bits (275), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 41/279 (14%), Positives = 81/279 (29%), Gaps = 22/279 (7%)

Query: 144 QKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQ 203
           Q     +   +  A +     + P +    G                      P      
Sbjct: 324 QSFDEPLMEEESAAAEHPYYNNIPNKMPPPGGFINARLKAKI-----------PTAADTA 372

Query: 204 PWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDS 263
                   IS+       V  +      +     S +    +  +   A  +      ++
Sbjct: 373 QKYLTPTHISEYLKTGFLVFSETLIHKNIMPEGKSEATARAEMPMYVNAQHI----NMET 428

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
               +   +S +S   +      P     + K      +   + +            + W
Sbjct: 429 LLALQADAESDISGNTDSTKESSPEKDLFDMK-NFSCCLTLPTSIQLLIMKERERGEKPW 487

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           Y G +SR +AE LL+ C    +LVR S T+   + L+   +    H+ L    E    + 
Sbjct: 488 YQGEMSRKEAEQLLKKC--GDFLVRKSTTNPGSYVLTGMQNGQAKHLLLV-DPEG--TVR 542

Query: 384 QNSPPFSSVPEIVHHYASRKLPI-KGAEHMSLLYPVAIR 421
                F S+  +++H+    LPI      + L  P   +
Sbjct: 543 TKDRVFDSISHLINHHLENNLPIVSSGSKLCLQQPAERK 581


>UniRef50_UPI0000D56E93 PREDICTED: similar to predicted protein n=1 Tax=Tribolium castaneum
           RepID=UPI0000D56E93
          Length = 412

 Score =  110 bits (275), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 35/212 (16%), Positives = 69/212 (32%), Gaps = 13/212 (6%)

Query: 207 WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLED-SSA 265
             +ER  + F    K  + +       +        + +R        + E +       
Sbjct: 200 LTEERTCEIFQKMQKEQQQVAKEAEEAEQKQEQLWREQERKAKQAEQQIREIARRAREEH 259

Query: 266 QFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYH 325
           +    E           G  P R +      +               +         W+H
Sbjct: 260 RLTNFEIDTSYSTINNTGVPPGRGAVVEWYKSHERPKWTGLDRSNNVES--------WFH 311

Query: 326 GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQN 385
           G I+R++AE LL      S+LVR SE     +++S ++ +   H  +S        LG N
Sbjct: 312 GLITRSEAEKLLLDRPYGSFLVRLSERIWG-YAISYRAKEKCKHYLVSA-GLKYQFLGNN 369

Query: 386 SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYP 417
                ++ +++ ++     P+ G E +    P
Sbjct: 370 QIEHETLRDLIEYHRVH--PLTGGEKLVEACP 399


>UniRef50_A9VDX4 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VDX4_MONBE
          Length = 476

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 46/260 (17%), Positives = 82/260 (31%), Gaps = 14/260 (5%)

Query: 169 EPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPW 228
           E +      + E     RE R     +R  EE      ++++          +       
Sbjct: 207 EAQRQAEAKQQEIYMSMREMREQARKQREMEERQMDQMFQEQESRSKQHEAEQRAAAERA 266

Query: 229 PPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPR 288
                  ++     +     + P           +S            PG      LPPR
Sbjct: 267 RKAAQATENIFKQLEAHSKPAAPQVARATNMARSASLAKRPASPPPTGPGHSNTLPLPPR 326

Query: 289 LSA---GNPKSAKPLSME------PSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRL 339
             +      + +KP S+E       +S +      +     + W+HG ISR +AE LL+ 
Sbjct: 327 KGSMADVGARPSKPSSLEDVLHWFRTSEIPRGVGKSATGRWENWFHGPISRPEAERLLKG 386

Query: 340 CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSP-PFSSVPEIVHH 398
             + ++L+R S      ++LS   S  + H  +  +     V G  S     S+  +V  
Sbjct: 387 KPKGAFLLRISTRIWG-YTLSFVDSDRYKHFLVDASDGKYSVFGAQSNATHMSLSRLVAF 445

Query: 399 YASRKLPIKGAEHMSLLYPV 418
           +              L  PV
Sbjct: 446 HKK---VAVSKTGTMLTEPV 462


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 22/121 (18%), Positives = 50/121 (41%), Gaps = 7/121 (5%)

Query: 299 PLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
             + + +S    +         ++WYHG I+R   E +L    + ++LVR+S     D++
Sbjct: 23  NTNGKQTSVDRRYVANNEQH-PKLWYHGNITREHTEKILSGQADGTFLVRDSTNFPGDYT 81

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           L +  +    H ++ +   +  +   +   F ++ +++ HY              L+ PV
Sbjct: 82  LCMAFNGKVEHYRIYQL--NGILTCDHEETFDNLTQLIAHYKRD----ADGLCHRLITPV 135

Query: 419 A 419
            
Sbjct: 136 I 136


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 48/282 (17%), Positives = 97/282 (34%), Gaps = 16/282 (5%)

Query: 145 KMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEG---EGAPWPRESRLPEDDERPPEEY 201
           K++ E R     +       D P  P +              +  E   P    +P    
Sbjct: 141 KIVVECRKEGIVSYSTPESLDQPGGPPKWEKCRLALVKAVGGYMLEFYSPPKSTKPRSGV 200

Query: 202 DQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLE 261
                 +    +     D +    L     +  +  +    D    ++     +   +  
Sbjct: 201 FCALITEARETTALEMPDHENTFVLKANNSLEFVILARDTDDMRSWLATIKYCIRSGAGY 260

Query: 262 DSSA---QFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
             +A   Q +    +   P R   GR   RLS+    S   +       +   TD    L
Sbjct: 261 GDTAPGDQRDYHSDAPELPPRHVSGRGGDRLSSS---SNFDMCPSTGDNISMETDIGQTL 317

Query: 319 ENQVWYHGAISRTDAENLLRL---CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRT 375
           + + W+HG + R++A NL+          +LVR SET   +F L+        H++++  
Sbjct: 318 KKEFWFHGTLGRSEATNLVLHDGARGHGLFLVRQSETRTGEFVLTFNFQGRAKHLRMTIN 377

Query: 376 KEHKYVLGQNSPPFSSVPEIVHHYASRKLPIK--GAEHMSLL 415
            + +  +      F S+ E++ H+  + +P++  G   ++L 
Sbjct: 378 DQGQCRVQHF--WFQSIYEMLEHFRQQPIPLESGGNSDVTLT 417


>UniRef50_UPI000180BA50 PREDICTED: similar to growth factor receptor-bound protein 10 n=1
           Tax=Ciona intestinalis RepID=UPI000180BA50
          Length = 553

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 38/265 (14%), Positives = 86/265 (32%), Gaps = 27/265 (10%)

Query: 178 EGEGAPWPRESRLPEDDERPPEEYD-QPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLD 236
                 +P  ++ P      P  +  +P ++K   I + F V+               ++
Sbjct: 288 HSAQVWFPINNKKPTSSAPYPHCFCLKPRKFKNGSIIRWFCVESTHTMSAWISGLRLTMN 347

Query: 237 SS-------PSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRL 289
            S        +      ++   +S       + ++  F G     +   +E       + 
Sbjct: 348 GSRFYESYLSARRQSQSNLVRSSSDRTINRHDFAAMDFRGETGRVIHDPKEVAMLELEQQ 407

Query: 290 SAG----------NPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR- 338
           S+              S + +    +             + Q W++G I+R +A   L  
Sbjct: 408 SSWRRRLINRTITGQASDRNIVGSSAPTKQVAFFARAIHQTQTWFYGKITREEATEELHR 467

Query: 339 -LCKEASYLVRNSETSKNDFSLSLKSSQGFMHM---KLSRTKEHKYVLGQNSPPFSSVPE 394
               +  +LVR+S T      ++L  +Q   H+   ++ R  ++ Y        F  + +
Sbjct: 468 NGNVDGLFLVRDSHTIPGGIVVTLCHNQKSRHIPITQIERNGQNFYTADNGETRFVDMIQ 527

Query: 395 IVHHYASRKLPIKGAEHMSLLYPVA 419
           +V  +   K    G+    LL+  +
Sbjct: 528 LVDFHRLNK----GSLPCLLLHECS 548


>UniRef50_UPI0001924162 PREDICTED: similar to SH2-B PH domain containing signaling mediator
           1 n=1 Tax=Hydra magnipapillata RepID=UPI0001924162
          Length = 984

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 32/214 (14%), Positives = 66/214 (30%), Gaps = 21/214 (9%)

Query: 207 WKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQ 266
             K  I    A       +    P     D    +               +     +   
Sbjct: 720 LPKRHIVSPLAKQQSSFDNESSEPLRSIFDQENEIFSDTLPERSTYQAPVQNPKVINGYN 779

Query: 267 FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHG 326
               + S  +P    +   P                E             PL    W+HG
Sbjct: 780 ITSSQDSQAAPITTPEVLSPIP--------------ETQCDWTNPFGENHPLAVYPWFHG 825

Query: 327 AISRTDAE-NLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
            I+R  +  ++L+        +LVR SET + ++ L+        H+++S   E    + 
Sbjct: 826 TITRVQSSMHVLQQGSSWHGVFLVRQSETRRGEYVLTFNLQGRSKHLRMSLNSEGNCRVQ 885

Query: 384 QNSPPFSSVPEIVHHYASRKLPIK--GAEHMSLL 415
                F ++ +++ H+    +P++  G++ + L 
Sbjct: 886 --HLRFETIFDMLEHFRLHPIPLENNGSDDVRLT 917


>UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B2C65
          Length = 846

 Score =  110 bits (274), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 41/275 (14%), Positives = 71/275 (25%), Gaps = 26/275 (9%)

Query: 170 PEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWP 229
               G   E +  P  R        E        P                      P  
Sbjct: 42  GAAPGGQPEDQVQPCLRSPGYAHSSEMYTHVGTAPRRSSPLTPEAQHVSQADGCVRKPSN 101

Query: 230 PPVGQLDSSPSL----------PDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPG- 278
                  ++                    S P       +L+      E       SP  
Sbjct: 102 MAASGAKAASPQDLYVPMDPIYEGAHTHKSAPTKSPRGVALKQEPDVLEPTAPEEKSPPF 161

Query: 279 -------REEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRT 331
                    +      + S G                 E    +  L++  WYHG I   
Sbjct: 162 MFFSLTGSADSSGEYVKFSKGKFWLEPLSENLKKQLEEELRLSSTNLKSHAWYHGPIPWE 221

Query: 332 DAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSR---TKEHKY---VLGQN 385
            +E+L+       +L+R+S++++ +F L+    Q  +H  + +        Y        
Sbjct: 222 VSESLV--VNHGDFLIRDSQSNRGNFVLTSNWQQKTLHFLIRKAALQPGETYPRVQYSLE 279

Query: 386 SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
              F S+P +VH Y   + P+       +  PV  
Sbjct: 280 EEAFESLPALVHFYVGSRAPLTQWSGAQIQRPVNR 314


>UniRef50_A9JR87 Zgc:171590 protein n=4 Tax=Clupeocephala RepID=A9JR87_DANRE
          Length = 264

 Score =  110 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 32/198 (16%), Positives = 72/198 (36%), Gaps = 18/198 (9%)

Query: 228 WPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPP 287
            P    +  ++ ++     D +GP +      +  S   +        +    E+  +  
Sbjct: 4   RPSKDRRGPNAHAVLLDTEDSNGPLTMESIRYVLVSLYDYPSRGPGDCAIRVGERLNILS 63

Query: 288 RLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLR--LCKEASY 345
                  K +   +   S     +T     L N+  + G +S+  +E LL     +  S+
Sbjct: 64  DEG-EWFKVSSSATGNESYIPSNYTA---KLYNRWQFVG-LSKRKSEELLMLPHNQPGSF 118

Query: 346 LVRNSETSKNDFSLSLKSSQ-----GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYA 400
           L+R SET   +++LS++ S         H ++S      + +      F ++ +++ HY+
Sbjct: 119 LIRESETFPGNYTLSVRKSGSQERASVKHYRISCIDNGWFYIS-PGLTFRTLSDMIAHYS 177

Query: 401 SRKLPIKGAEHMSLLYPV 418
                +      +L  P 
Sbjct: 178 -----VSDGLCCTLGEPC 190


>UniRef50_Q9H3Y6 Tyrosine-protein kinase Srms n=19 Tax=Amniota RepID=SRMS_HUMAN
          Length = 488

 Score =  110 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 49/206 (23%), Positives = 78/206 (37%), Gaps = 16/206 (7%)

Query: 225 DLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE---PSLEDSSAQFEGPEKSCLSPGREE 281
           D  WP        +P   D + D        P    P L  +   F       LS  R +
Sbjct: 17  DKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGD 76

Query: 282 KGRLPPRLSAGNPKSAKPLSMEPSSPLGE----WTDPALPLENQVWYHGAISRTDAENLL 337
           +         G    A+ LS +PS+ L             L +Q WY   +SRT A+ LL
Sbjct: 77  RLCALEEG--GGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLL 134

Query: 338 RLCKE--ASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEI 395
                   ++L+R SE+S   +SLS+++     H ++S   +    L Q    F  + E+
Sbjct: 135 LSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYL-QKGRLFPGLEEL 193

Query: 396 VHHYASRKLPIKGAEHMSLLYPVAIR 421
           + +Y +    I+      LL P   +
Sbjct: 194 LTYYKANWKLIQNP----LLQPCMPQ 215


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score =  110 bits (273), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKS---SQGFMHMKLS 373
            L+   W+ G I+R  AE LL   +   +LVR S     D++L + S   ++   H ++ 
Sbjct: 26  ELDLANWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVI 85

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
            T +++  +      F ++ E++ HY              L  P+  +T
Sbjct: 86  STNDNRVTV-DEDAFFPNLIELIKHYERD----ADGLCTMLKKPLKKKT 129


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  110 bits (273), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 1/96 (1%)

Query: 319 ENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
           EN  W+HG ISR DAE +LR    +  +LVR S +S+ D+ LS+      +H  + R  +
Sbjct: 5   ENLCWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGD 64

Query: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMS 413
             +    +  P   +  ++ HY   K  +     + 
Sbjct: 65  DAFFSIHDHTPIHGLDSLIEHYQKDKGNLVTRLQVI 100



 Score = 68.1 bits (164), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 29/146 (19%), Positives = 47/146 (32%), Gaps = 43/146 (29%)

Query: 310 EWTDPALPL-ENQVWYHGAISRTDA---------------------------------EN 335
              +P  PL    +WYHG + RT A                                 E 
Sbjct: 270 NAYEPQRPLTHRDLWYHGTLERTAAVDYLKDFAVKLLPNLAHRQQQQQPDRDGNKENGEC 329

Query: 336 L--LRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVP 393
           L  L      +YLVR S     D  L++       H  + R ++  ++     P  +S+ 
Sbjct: 330 LDGLEQSTSGTYLVRYSAKQNVD-VLTMLYDNEPKHFIIQRQQD--WLYIDEGPYMNSLE 386

Query: 394 EIVHHYASRKLPIKGAEHMSLLYPVA 419
            ++ HY            ++L +PV 
Sbjct: 387 HLIEHYTR----FSDGLPINLRFPVT 408


>UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=Euteleostomi
           RepID=GRB7_HUMAN
          Length = 532

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 35/219 (15%), Positives = 70/219 (31%), Gaps = 11/219 (5%)

Query: 210 ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG 269
               ++    +   +   +   + +               G             +  F G
Sbjct: 320 SEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMDFSG 379

Query: 270 PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAIS 329
                +   RE          A   K+   LS+    P    +  A     Q+W+HG IS
Sbjct: 380 HAGRVIENPREALSVALEEAQAWRKKTNHRLSL--PMPASGTSLSAAIHRTQLWFHGRIS 437

Query: 330 RTDAENLL--RLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH---KYVLGQ 384
           R +++ L+  +   +  +LVR S+ +   F LSL   Q   H  +  ++E     + +  
Sbjct: 438 REESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFSMDD 497

Query: 385 NSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
               F+ + ++V  +   +    G     L +      L
Sbjct: 498 GQTRFTDLLQLVEFHQLNR----GILPCLLRHCCTRVAL 532


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 40/184 (21%), Positives = 65/184 (35%), Gaps = 7/184 (3%)

Query: 239 PSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAK 298
                          P P  S E SS        +       E      +  + +    +
Sbjct: 317 QEATPASVRPMASPQPTPVMSHELSSGGGGALAIAAAIGVSREHTPTNQKRPSVDAFDMR 376

Query: 299 PLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFS 358
           P +    +P    T     L+++ W+HG ++R +AE LL    +  +LVR S T+K  F 
Sbjct: 377 PFA-NTLNPPATPTSATNALQSKPWFHGHVTRKEAEQLLSH--DGDFLVRESTTTKGQFV 433

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPI-KGAEHMSLLYP 417
           LS      + H+ L        V+      F SV  ++  +    LPI      + L  P
Sbjct: 434 LSGVQDGQYKHLLLV-DPNG--VVRTKDRQFDSVSHLISFHRDNTLPIVSSGSVLLLRQP 490

Query: 418 VAIR 421
           V  +
Sbjct: 491 VTRQ 494


>UniRef50_A8P112 Variant SH3 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P112_BRUMA
          Length = 931

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 8/143 (5%)

Query: 275 LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAE 334
            SP  +       R S+    S + + +   S   ++ +    +  Q WY G + R D+E
Sbjct: 731 SSPQLQLPLTNEQRKSSS---SIENMFLPQKSQSQDYVNT--EVVGQQWYRGPMKRWDSE 785

Query: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
            LLR   + ++LVR S +++  + +S+  +    H K+ ++ E +Y L   S  FSSV E
Sbjct: 786 ELLRGTPDGTFLVRFS-SAQQKYVISISFNGDVKHTKVEQSPEGRYYL-DESTMFSSVVE 843

Query: 395 IVHHYASRKLPIK-GAEHMSLLY 416
           ++++Y    L       + +L +
Sbjct: 844 LINYYRENNLRESFETLNTTLRH 866


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 31/109 (28%), Positives = 48/109 (44%), Gaps = 8/109 (7%)

Query: 318 LENQVWYHGAISRTDAENLLR--LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKL--S 373
             ++ W+H  ISR +AE+LL+     + S+LVR S     DFSLS        H  +   
Sbjct: 317 HFSEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRKNRVQHCHIKSR 376

Query: 374 RTKEH--KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            T +   KY L      F ++  +++HY +  L       + L  PV  
Sbjct: 377 PTNDGTAKYFLVGP-KGFDNLYSLINHYQTNPLK-SDKFELMLTEPVPQ 423



 Score = 95.8 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 49/116 (42%), Gaps = 10/116 (8%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRL-CKEASYLVRNSETSKND--FSLSLKSS 364
           L E          + WYH  ++R  AE +LR   K++ +LVR       +  +++S ++ 
Sbjct: 417 LTEPVPQPNAHLGKDWYHENLTRLQAEEMLRRMRKDSYFLVRKRNDGDQNESYAISFRTG 476

Query: 365 QGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
               H  + + +   +++G    PF S+ E++ HY    L         L YP   
Sbjct: 477 GTIKHCVIKK-EGRLFMIGT--APFESLTELIAHYEKNPL----YRKTKLKYPCNQ 525


>UniRef50_C3YYE3 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3YYE3_BRAFL
          Length = 1043

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 62/362 (17%), Positives = 113/362 (31%), Gaps = 35/362 (9%)

Query: 78  KKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGY 137
            + N  ST  +   R     E  P  +  +   P     +      + G P+      G 
Sbjct: 620 TEVNRDSTVLVGGRRRESCGENSPNGVDSNRQVPPSSPNSLMPPPLSVGHPQAGSSRPG- 678

Query: 138 MEPYEAQKMMAEIRGSKETATQPLPLYDTPYEP--EEDGATAEGEGAPWPRESRLPEDDE 195
                                +P  LY               +   +P PR  + P+  +
Sbjct: 679 ---------DYHDVVLPARNARPTSLYQNTGSNYVNTGNYAGKMPESPGPRSPKSPKILQ 729

Query: 196 RPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDR--DISGPAS 253
           R  E+        K+R+S       K +             ++  LPD      +  P +
Sbjct: 730 RDYEDSRNQEANFKKRMSVWLETCKKNLDPRKRHSASDLKLANRPLPDLPPVEAMKPPPN 789

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
           P   P L ++  + +   ++ +      K    P  + G  +   P+   P     E+  
Sbjct: 790 PAVLPGLRENPPEVDPLPENSVFLKNRPKYGRVP-STTGEKEDLPPVEGSP----REFAR 844

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
               LE   WY G ++  DAE  L    + S+LVR+S   +   SLS ++  G  H ++ 
Sbjct: 845 SLKELERCGWYWGPMNWDDAETKLAGKPDGSFLVRDSSDDRYILSLSFRARGGTHHTRIE 904

Query: 374 RTKEHKYVLGQNSPPF---SSVPEIVH------------HYASRKLPIKGAEHMSLLYPV 418
            +K   +             S+ E +             +Y   +        + LL P+
Sbjct: 905 HSK-GVFSFWSQPKSHGCSPSIVEFIETAMLHSNTGKFQYYLRARALGSPPVPVLLLKPI 963

Query: 419 AI 420
           + 
Sbjct: 964 SR 965


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 4/109 (3%)

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCKEASYLVRN-SETSKNDFSLSLKSSQGFMHMKL 372
               L++  WY G ISR +    LR   + ++LVR+ S   + +++L+L+       +K+
Sbjct: 321 SPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKV 380

Query: 373 SRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVAI 420
              ++  Y   +    F SV ++++HY    L    A     LLYPV+ 
Sbjct: 381 FH-RDGHYGFSEP-LTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427



 Score =  100 bits (249), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 3/112 (2%)

Query: 308 LGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGF 367
           L E  D     E + WY G I+RT AE +L   ++ ++L+R S + +  ++ S+      
Sbjct: 607 LMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVVDGDT 665

Query: 368 MHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKG-AEHMSLLYPV 418
            H  + RT    +   +    + S+ E+V HY    L     A  ++L +PV
Sbjct: 666 KHCVIYRTATG-FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPV 716


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 8/108 (7%)

Query: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKND---FSLSLKSSQGFMHMKLSR 374
           LE   WYHG + R D   LL   K+  +LVR +E  K +     LS+K +   MH  +  
Sbjct: 8   LEFAEWYHGLLPRKDINILLS--KQGQFLVRETEIKKGEGLQLVLSVKWNDKTMHFIIRH 65

Query: 375 TKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRT 422
                ++       F+S+  ++ ++   K PI       LL+ V  ++
Sbjct: 66  VDGKVFI---EKRQFNSIHALIRYHLVSKDPITDQSGAMLLHAVPRQS 110


>UniRef50_Q13322 Growth factor receptor-bound protein 10 n=44 Tax=Euteleostomi
           RepID=GRB10_HUMAN
          Length = 594

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 37/235 (15%), Positives = 80/235 (34%), Gaps = 12/235 (5%)

Query: 196 RPPEEYDQPWEWKK--ERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPAS 253
           +P +  ++  E +       +     +   + L +   + Q    P              
Sbjct: 365 KPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPFSTPV 424

Query: 254 PLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTD 313
                +   +   F G     +    E +        A   +S +   +   SPL   T 
Sbjct: 425 RSVSENSLVA-MDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTL 483

Query: 314 PALPLENQVWYHGAISRTDAENLLRLCK--EASYLVRNSETSKNDFSLSLKSSQGFMHMK 371
             +    Q W+HG ISR ++  +++     +  +L+R+S+++   F L+L   Q   + +
Sbjct: 484 STVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQ 543

Query: 372 LSRTKEH---KYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
           +   ++     + L   +  FS + ++V  Y   K    G     L +      L
Sbjct: 544 ILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNK----GVLPCKLKHHCIRVAL 594


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 56/382 (14%), Positives = 121/382 (31%), Gaps = 21/382 (5%)

Query: 52  PLNSHCAHREPISSSPQPVANGPKQKKKSNWRS---------TTRLRIIRLRDRLEPRPL 102
           P +   + R P+ ++P+P  +  +  +  N             + + +  L ++  P   
Sbjct: 86  PSSQPRSQR-PLPAAPRPDPSQEQVCRLGNGARCPPHVICVVVSAVSMPDLSEQFTPPET 144

Query: 103 AILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLP 162
           A     +    V++ G  S     + +    +   +  Y         +      ++ + 
Sbjct: 145 APPTLVSLIQAVEKRGLESEALYRSTDSPVPD---VPVYSLCSESDLGQKDVAYLSECVL 201

Query: 163 LYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERP-PEEYDQPWEWKKERISKAFAVDIK 221
            Y          A    +       ++   +          Q  E               
Sbjct: 202 RYLKALPSPLIPACIYPQLQTAVGLTQQALNQAAGGTLGEGQDREVSLVIEKATTVPLHH 261

Query: 222 VIKDLPWPPPVGQLDSSPSLPDGDRD-ISGPASPLPEPSLEDSSAQFEGPEKSCLSPGRE 280
            +        + ++  + +    D   +     PL   S   +         +     + 
Sbjct: 262 RLTLQFLLTHLAKVTQAQASNGLDAQTLGQIFGPLLVWSSTSAHWTPLDEGFAETVVEKL 321

Query: 281 EKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLC 340
              R   +        AKP   + +      T     L +  WY G ISR +    LR  
Sbjct: 322 LTERTTEQDVTPPVLPAKPAKSKVAPSAMTDTSSL--LNDAEWYWGEISREEVNEKLRDT 379

Query: 341 KEASYLVRNSETS-KNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHY 399
            + ++LVR++ +  + +++L+L+       +K+   +E +Y   +    F SV E+++HY
Sbjct: 380 PDGTFLVRDASSKLEGEYTLTLRKGGNNKLIKI-YHREGRYGFSEP-LTFLSVVELINHY 437

Query: 400 ASRKLPIKGA-EHMSLLYPVAI 420
               L    A     LLYPV+ 
Sbjct: 438 RHESLAQYNAKLDTKLLYPVSK 459



 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 30/118 (25%), Positives = 56/118 (47%), Gaps = 2/118 (1%)

Query: 306 SPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQ 365
           S   E  + +   +   WY G I R+ AE +LR   + ++L+R S+T K  ++ S+    
Sbjct: 605 SYSLEEDESSPHHDESTWYVGDIKRSQAEEMLRGTCDGTFLIRESQTQKGSYACSVVVDG 664

Query: 366 GFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGA-EHMSLLYPVAIRT 422
              H  + +T    Y   +    +SS+ ++V HY +  L       +++L +PV  R+
Sbjct: 665 DTKHCVVYKTVTG-YGFAEPYNLYSSLKDLVLHYKNVSLVQHNDHLNVTLAHPVLARS 721


>UniRef50_C1LZF7 Growth factor receptor-bound protein, putative n=3 Tax=Schistosoma
           RepID=C1LZF7_SCHMA
          Length = 234

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 28/155 (18%), Positives = 56/155 (36%), Gaps = 16/155 (10%)

Query: 259 SLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPL 318
              ++S  F    +  L   +    ++       N   A+        P        + +
Sbjct: 1   MEAEASYDFVANAEDELGFKKGSLLKILCVEDDPNWYLAEQEGRTGLIP-----CNYITM 55

Query: 319 ENQVWYHGAISRTDAENLLRL---------CKEASYLVRNSETSKNDFSLSLKSSQGFMH 369
               WY    SR +AE  L+            + ++++R SE     FSLS+K     +H
Sbjct: 56  RPHPWYIRHCSRMEAEERLQEIDQETAQHLQPDGAFILRQSEADGKGFSLSVKQGCEVLH 115

Query: 370 MKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKL 404
            K+ + +  KY    +   F S+ +++ H+    +
Sbjct: 116 FKVLQDEAGKYFFWLS--KFDSINQLIDHHRKTSI 148


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 57/379 (15%), Positives = 111/379 (29%), Gaps = 32/379 (8%)

Query: 66  SPQPVANGPKQKKKSNWRSTTRL-RIIRLRDRLEPR----PLAILEDYADPFDVQETGEG 120
           +PQ       Q+ KS+            L+D   P+     +++     +    + +   
Sbjct: 254 NPQDEYTKLIQENKSDSDEDVFTFDTSLLQDYSSPKVEATKMSVNNLTYESLKAELSKME 313

Query: 121 SAGASGAPEKVPEND-----GYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGA 175
                 A +   + +         P   Q                L L D   E E+  A
Sbjct: 314 QRLEEYAKQHAEKEEKLKALNXAAPDAQQNSEVPKAVLISNLQAELKLLDCTLEREKVKA 373

Query: 176 TAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQL 235
               E      ES  P  D  P  E     +                         V   
Sbjct: 374 EKVKEDLQGIGESP-PLFD--PLGEGVVXTDPTSPTTPTHPGDHAS-PSATLDTESVENG 429

Query: 236 DSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPK 295
               +   G+   +  ++ L +   +  S      + +        +G        G   
Sbjct: 430 GKKAAEKGGNSKAAKISNTLKKSFAKGFSMFRHRMQSNTSQSIDSTEGEAGEPGEPGETA 489

Query: 296 SAKPLSMEPSSPLGE---------WTDPALPLENQVWYHGAISRTDAENLLRLCKEASYL 346
           +    S +PS+ + +            P   +E + W++  + R +AE   +      YL
Sbjct: 490 TDAASSADPSAIVEDNESETGSTTDVPPETRVEEERWFYPNMERKEAEEKCKNT--GDYL 547

Query: 347 VRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH----KYVLGQNSPPFSSVPEIVHHYASR 402
           +R S + +N + L++  +    H  +    +     KY     S  F SV E++  + + 
Sbjct: 548 IRYS-SKQNRYVLTVCWAGQGKHFVIQEAPDEQTKTKYRF--ESRSFPSVRELLDFHVNS 604

Query: 403 KLPIKGAEHMSLLYPVAIR 421
           + P+  A    L  P+   
Sbjct: 605 QTPVTKASGAILSRPILRE 623


>UniRef50_A8NSH4 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NSH4_BRUMA
          Length = 537

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 61/407 (14%), Positives = 117/407 (28%), Gaps = 45/407 (11%)

Query: 27  GHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVA-----NGPKQKKKSN 81
           G      P  +  + +     + P    S  + R  +  S    A           + S+
Sbjct: 124 GSGPVFGPHENEDTLKQQLSRIKPWNSGSGSSARNKVQESVYDDADSLFGLSYNGSEPSH 183

Query: 82  WRSTTRLRIIR-LRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPEN------ 134
               +       L+   E  PL    +  D   +    +           +  +      
Sbjct: 184 IAPASESPYKGILKKSTENFPLNNNSNKKDKLSIDIDIKQKTKEKACGTYLSTDTVKTFG 243

Query: 135 --DGYMEPYE--------AQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPW 184
                 +P           Q   A+   S         L      P+ +    +      
Sbjct: 244 AIANAAKPAPLVGLSHSVKQFTPAQKTNSGHVVKFRPDLSSRHDLPDINDEITK------ 297

Query: 185 PRESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDG 244
            R+S + E  +   +++D+  E +  R+ +A+    +  ++           +       
Sbjct: 298 -RQSEIFEKIKEKYQQFDREAEQEARRVEQAWEEQERRAREAEAEIRHIAQRAREQHRQQ 356

Query: 245 DRDISGPASPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEP 304
               S P   + +     +S Q            +  +  +         KS +      
Sbjct: 357 TLRTSAPFLXVLKDVKNTASVQEILKNLPRPPKPKSREAII------DWFKSEELRHGTG 410

Query: 305 SSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSS 364
             PL             VW+HG I+R  A+ LL+     S+LVR SE     ++LS    
Sbjct: 411 LDPL--------THRPAVWFHGIITRNAADELLQGKPSGSFLVRVSERIWG-YTLSYMVG 461

Query: 365 QG-FMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAE 410
            G   H  + +  +    LG N      + E+V  +    +  KG E
Sbjct: 462 DGNIKHFMIEKIPQGYQFLGINQVVHQRLHELVAFHEISPITSKGNE 508


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 26/141 (18%), Positives = 56/141 (39%), Gaps = 9/141 (6%)

Query: 264 SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVW 323
              F     + LS  + +  ++               + +       + +    ++   W
Sbjct: 6   KYDFMATGDTELSFRKGDILKILSPEDDWFKAEM---NGQEGYVPQNYIE----IQTPRW 58

Query: 324 YHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLG 383
           +    SR+ AE LLR      +++R  ++S  +FS+S++      H K+ R    +Y L 
Sbjct: 59  FQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFKVMRDSRGQYFLW 118

Query: 384 QNSPPFSSVPEIVHHYASRKL 404
             S  F+S+ ++V  Y +  +
Sbjct: 119 --SEKFTSLNKLVDFYRTSSI 137


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 47/220 (21%), Positives = 76/220 (34%), Gaps = 19/220 (8%)

Query: 209 KERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFE 268
           K RI          +    W       D S +  D    I      L +P  ++    F 
Sbjct: 455 KRRIILKHKKLPDGVDGTDWRMAGLADDMSVADGDLSNSIKNDILFLEDPIDKEWHPHFF 514

Query: 269 GPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAI 328
              +S L    E            +  ++  L    +              ++ W+HG +
Sbjct: 515 VLTQSKLHYTDETAVTSQEDEEEESNDTSLQLEGLGND---------EMHFSEKWFHGKL 565

Query: 329 --SRTDAENLLRL---CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEH---KY 380
              R  AE+LL+      + ++LVR S+T   DFSLS        H ++   +E    KY
Sbjct: 566 EGGRRKAEDLLKEYSYLGDGTFLVRESDTFVGDFSLSFWRKDSVNHCRIRSKQERGQTKY 625

Query: 381 VLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAI 420
            L  N   F S+  ++ HY    L  +  + + L  PV  
Sbjct: 626 YLIDN-LAFDSLYSLITHYQKYPLRSQDFQQI-LKEPVPQ 663



 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 28/123 (22%), Positives = 55/123 (44%), Gaps = 8/123 (6%)

Query: 300 LSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFS 358
            S +    L E          + WYH  + RT AE++L+    + ++LVR +    N ++
Sbjct: 649 RSQDFQQILKEPVPQPQSHHGKPWYHEKLDRTRAEDMLKRIPSDGAFLVRQNGVDTNSYA 708

Query: 359 LSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +S ++     H  + + +   + +G     F S+ E+V++Y  + L       M L +PV
Sbjct: 709 ISFRAEGKIKHCIIKQ-EGRLFTIGNAQ--FESLVELVNYYEKKPL----YRKMKLKHPV 761

Query: 419 AIR 421
             +
Sbjct: 762 NEK 764


>UniRef50_UPI00016E6E61 UPI00016E6E61 related cluster n=3 Tax=Takifugu rubripes
           RepID=UPI00016E6E61
          Length = 473

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 68/426 (15%), Positives = 130/426 (30%), Gaps = 47/426 (11%)

Query: 24  GSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSNWR 83
             P    R       S    H +   P   + +          P            +N  
Sbjct: 62  KVPARDYRDEEHLPESYHPRHMYEEPPEEQDDN------YEPPPSHTPLAT-----ANSA 110

Query: 84  STTRLRIIRLRDRLEPRPLA----ILEDYADPFDVQETGEGSAGASGAPEKVPENDGYME 139
           S +    +  R  L  RP         + + P   +     S      P+     D Y+E
Sbjct: 111 SFSGEEYLDNRHSLPHRPPKKPVFPPRNASRPQRARVPDLESDEDYIDPDDTHTEDNYVE 170

Query: 140 PYEA------------QKMMAEIRGSKETATQPLPLYDTPYEP-EEDGATAEGEGAPWPR 186
           P E             Q     +   +         +  P+         A+    P   
Sbjct: 171 PAEGPDSTLIMVLGLFQASRIAVPTPRPCTLPQSQFHSLPWMSCPSPLTVADTFCLPRMN 230

Query: 187 ESRLPEDDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDR 246
             R P  +  P  +     E++      +     + ++  P P P  Q  +   L    +
Sbjct: 231 MRRSPTCEAEPTSD----EEYEVCDPGGSSHQPAEALRLPPKPLPREQEITPLLLSLFLQ 286

Query: 247 DISGPASPLPEPSLEDS--SAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEP 304
           ++   +S   E        S +FE    +     R +           +        +  
Sbjct: 287 EVPKTSSEASECQQRPDLKSREFEKFRHTSPPAVRPKLQLRLQLQLCSSTPPCLAQQLRG 346

Query: 305 SSPLGEWTDPALPLENQVWYHGAISRTDA-ENLLRLCKEASYLVRNS--ETSKNDFSLSL 361
            +P      P   + N+ WY GA  R  A E LLR  ++ +++VR S  + ++  ++L +
Sbjct: 347 GAPRAG-QSPDQEIRNKHWYGGACDRKTADEALLRSNQDGAFMVRKSSGQDAQQPYTLVV 405

Query: 362 KSSQGFMHMKLSRT-KEHKYVLGQN---SPPFSSVPEIVHHYASRKLPIKGAEH-----M 412
             +    ++ +       +Y LG+       F+S+P I+ ++    L +   ++      
Sbjct: 406 FYNGRVYNIPVRFIAATQQYALGREKSGEEYFNSLPHIIENHQRTPLVLIDGQNNTKDTT 465

Query: 413 SLLYPV 418
            L YPV
Sbjct: 466 RLSYPV 471



 Score = 42.3 bits (97), Expect = 0.035,   Method: Composition-based stats.
 Identities = 40/246 (16%), Positives = 65/246 (26%), Gaps = 15/246 (6%)

Query: 83  RSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYE 142
           R+   +  +  R + +P P     DY D  +                   ++D Y  P  
Sbjct: 43  RADDVINSLCDRLKSKPLPKVPARDYRD--EEHLPESYHPRHMYEEPPEEQDDNYEPPPS 100

Query: 143 AQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPE---------- 192
              +      S          +  P+ P +         A  P+ +R+P+          
Sbjct: 101 HTPLATANSASFSGEEYLDNRHSLPHRPPKKPVFP-PRNASRPQRARVPDLESDEDYIDP 159

Query: 193 DDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPA 252
           DD    + Y +P E     +     +       +P P P     S           S   
Sbjct: 160 DDTHTEDNYVEPAEGPDSTLIMVLGLFQASRIAVPTPRPCTLPQSQFHSLPWMSCPSPLT 219

Query: 253 SPLPEPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWT 312
                     +  +    E        EE     P  S+  P  A  L  +P     E T
Sbjct: 220 VADTFCLPRMNMRRSPTCEAE--PTSDEEYEVCDPGGSSHQPAEALRLPPKPLPREQEIT 277

Query: 313 DPALPL 318
              L L
Sbjct: 278 PLLLSL 283


>UniRef50_UPI000180C4F3 PREDICTED: Src protein n=2 Tax=Ciona intestinalis
           RepID=UPI000180C4F3
          Length = 512

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 32/225 (14%), Positives = 75/225 (33%), Gaps = 16/225 (7%)

Query: 201 YDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSL 260
           +   +E       K    +     D    P   +  S+P         + P   + E  +
Sbjct: 8   FRCCFEEYDVSEVKDAKENSSFEFDEIKTPTQNRRLSTPIQ----DRPAPPIPQIEEEDI 63

Query: 261 EDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGN----PKSAKPLSMEPSSPLGEWTDPAL 316
             +   +       L+  + +   +  +    +     +     S+   S    +     
Sbjct: 64  YIALYDYVARTNKDLTFKKGDTMVILKKGQNWSIAQLLEPNPLYSVTEGSIPTNYVKKQS 123

Query: 317 PL-ENQVWYHGAISRTDAENLLRL--CKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLS 373
            +     W      R++A +LL         +L R   T+ N+++LS+++     H+K+ 
Sbjct: 124 SVVSQPSWMFDTADRSEAVSLLMQPCNNHGDFLARRRTTNPNEYALSVRNGATVNHIKIE 183

Query: 374 RTKEHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
           +     Y +  +   F+++ ++V +Y    L    A  + L  P 
Sbjct: 184 KMGGQGYSI-DHHTMFATLNDLVGYYQENML----ANDIRLRSPC 223


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 64/405 (15%), Positives = 110/405 (27%), Gaps = 54/405 (13%)

Query: 61   EPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYA-DPFDVQETGE 119
             P    P P A  P  +      S       R++   +          + D  D  E+  
Sbjct: 651  APQPQKPLPGATKPPTQTFEKANSFREKIRRRIKGTKQDSDRQADRSMSPDNPDQPESFS 710

Query: 120  GSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGSKETATQPLPLYDTPYEPEEDGATAEG 179
            G   +             M+  ++          +  A +  P        ++    ++ 
Sbjct: 711  GRLRSRITAHHTQRQFRLMKDTDSAS----PSTDRSIAERLPPGSSAAGRKKKKRKASKA 766

Query: 180  EGAPWPRESRLPE-------DDERPPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPV 232
              A   +  R  +        D     +Y  P    +   ++            P PP  
Sbjct: 767  NRAARQQLRRKHQLVDGMMASDMHTTADYCVPLLVARSEDTQ-LQAGSPDGDLRPEPPVF 825

Query: 233  GQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG-----PEKSCLSPGREEKGRLPP 287
             Q  S                 + + +    S Q  G      ++ C +  +    R   
Sbjct: 826  AQRASKAGPSIKSNLRDKLTKLVHKKTASGGSVQSGGRWVGAAQEVCRTCSKRIVQRSGS 885

Query: 288  RLSAGNPKSAKPL------------------------------SMEPSSPLGEWTDPALP 317
                G   S   L                              S   + P         P
Sbjct: 886  DGGGGMHASRTVLDFRKEFPDIDICEGGHDHLDGATSEMINLDSFLCNIPPQMTLSTNRP 945

Query: 318  LENQVWYHGAISRTDAENLLRLCKEASYLVRNSE-TSKNDFSLSLKSSQGFMHMKLSRTK 376
            L  + W+HG + R +   LLR   E  +LVR +    ++   LS+  +    H  +  T 
Sbjct: 946  LHEEEWFHGVLPREEVVRLLRN--EGDFLVRETTRNDESQTVLSVCWNG-HKHFIVQTTA 1002

Query: 377  EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIR 421
            E  Y      P F S+ E++ H    +LP+ G     L  PV   
Sbjct: 1003 EGHYRF--EGPAFPSIQELIVHQYQSELPVTGRSGAVLRKPVLRE 1045


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 4/104 (3%)

Query: 318 LENQVWYHGAISRTDAENLLRLCK-EASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
           + ++ W+H  IS  +AE LL+    + S+L R S ++   F+LS++      H+K+    
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG 60

Query: 377 EHKYVLGQNSPPFSSVPEIVHHYASRK-LPIKGAEHMSLLYPVA 419
           +   + G     F+++PE+V +Y     L  K  + + L  P+ 
Sbjct: 61  DFFDLYGGE--KFATLPELVQYYMENGELKEKNGQAIELKQPLI 102


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.296    0.107    0.258 

Lambda     K      H
   0.267   0.0329    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,014,913,419
Number of Sequences: 3077464
Number of extensions: 86332333
Number of successful extensions: 519857
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 3071
Number of HSP's successfully gapped in prelim test: 10159
Number of HSP's that attempted gapping in prelim test: 420850
Number of HSP's gapped (non-prelim): 56885
length of query: 423
length of database: 1,040,396,356
effective HSP length: 131
effective length of query: 292
effective length of database: 637,248,572
effective search space: 186076583024
effective search space used: 186076583024
T: 11
A: 40
X1: 16 ( 6.8 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.1 bits)
S2: 94 (41.1 bits)
