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Job DescriptionQ9HB75
Confidence99.92%DateWed May 9 17:48:56 BST 2012
Rank11Aligned Residues258
% Identity29%Templatec3fxiA_
PDB info PDB header:immune systemChain: A: PDB Molecule:toll-like receptor 4; PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex
Resolution3.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   23......30.........40.........50.........60.........70.........80.........90.........100..
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Query Sequence  SDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQR
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Template Conservation      
  

  
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Template Sequence  MELNFYKIPDNLPF. . STKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ. . . . SLSHLSTLILTGNPI
Template Known Secondary structure 
SS

SS


SS
S..S



S




B
TT


S
TT


TT




TTSST....T
SS


TT


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   41........50.... .....60.........70.........80.........90......... 100.........110....
 
   103......110.........120.........130.........140... ......150.........160.. .......170.........
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Query Sequence  RDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPAC. VLQMRGLGALLLSHNCLSE. . LPEALGALPALTFLTVT
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Template Conservation    
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Template Sequence  QSLALGA. . . . . . . . . . . FSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLS
Template Known Secondary structure 

TTT...........TTT
TT


TTS



STT
TTTT
TT



SS







GGGTT
TT



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   115....120. ........130.........140.........150.........160.........170.........180...
 
   180........ .190.......
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Query Sequence  HNRLQTLPP. ALGALSTLQ. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                      
                                                           
Template Sequence  SNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEF
Template Known Secondary structure  SS



GGGGTTGGG
SS



TT




TTTTTT
S

SSTTT


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   184.....190.........200.........210.........220.........230.........240.........250.........260...
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                                                                  
Template Sequence  RNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFG
Template Known Secondary structure  TTS


S


TTTTGGGGGSSS



STTTSGGGSS
SB
TT









SS
B
S
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   264.....270.........280.........290.........300.........310.........320.........330.........340...
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                 
                                                
Template Sequence  QFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQ
Template Known Secondary structure  S





SS

S
BS
SB





TT



SS

BT
S




S
ST
TT
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   344.....350.........360.........370.........380.........390.........400.........410.........420...
 
   198.200...... ...210.........220....
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . RLDLSQNLL. . DTLPPEIGGLGSLLELNL
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Template Conservation 
                        
                       
  
                     
  
 
Template Sequence  LEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDL
Template Known Secondary structure 


TTSSTBTTBTTTT
TT


TTS


B

TTTTTT
SS



B
TT

BGGG


S

TT

S



B
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   424.....430.........440.........450.........460.........470.........480.........490.........500...
 
   225....230.. .......240.........250..... ....260.........270.........280. ........290.......
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Query Sequence  ASNRLQSL. PASLAGLRSLRLLVLHSNLLASV. PADLARLPLLTRLDLRDNQLRDLPPE. . . . . LLDAPFVRLQGNPLGE
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Template Conservation 
 
 
  
    
  
  
  
 

 
 
  
       
  
  
 

 
 
              
  
 
  
   
Template Sequence  SQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFAC
Template Known Secondary structure  TTS


S

TTSGGG
SS



B
TTS

SS


SGGGG
TT






SS




S


TT


TT






S




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   504.....510.........520.........530.........540.........550.........560.........570.........580...
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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