Job Description P42681 Confidence 100.00% Date Thu Apr 26 09:52:37 BST 2012 Rank 4 Aligned Residues 434 % Identity 40% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å

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		86	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.		.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.
Predicted Secondary structure																																									.
Query SS confidence																																									.
Query Sequence		Q	V	K	A	L	Y	D	F	L	P	R	E	P	C	N	L	A	L	R	R	A	E	E	Y	L	I	L	E	K	Y	N	P	H	W	W	K	A	R	D	.	R	L	G	N	E	G	L	I	P	S	N	Y	V	T	E	N	K	I	T	N	L	E	I	Y	E	W	Y	H	R	N	I	T	R	N	Q	A	E	H	L	L
Query Conservation																																									.
Alig confidence																																									.																		.	.
Template Conservation																																																											.	.
Template Sequence		T	F	V	A	L	Y	D	Y	E	S	R	T	E	T	D	L	S	F	K	K	G	E	R	L	Q	I	V	N	N	T	E	G	D	W	W	L	A	H	S	L	S	T	G	Q	T	G	Y	I	P	S	N	Y	V	A	P	S	D	.	.	S	I	Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E	R	L	L
Template Known Secondary structure						S	S		B				S	S	S	B			B		T	T									S	S	S	S							T	T	T								G	G	G				T	T	.	.	S	G	G	G	S	T	T	B			S
Template Predicted Secondary structure																																																											.	.
Template SS confidence
		85	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.			.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
		165	.		.	.	.	170	.	.	.	.	.	.	.	.	.		180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
Predicted Secondary structure				.														.
Query SS confidence				.														.
Query Sequence		R	Q	.	E	S	K	E	G	A	F	I	V	R	D	S	R	.	H	L	G	S	Y	T	I	S	V	F	M	G	A	R	R	S	T	E	A	A	I	K	H	Y	Q	I	K	K	N	D	S	G	Q	W	Y	V	A	E	R	H	A	F	Q	S	I	P	E	L	I	W	Y	H	Q	H	N	A	A	G	L	M	T	R	L
Query Conservation				.														.
Alig confidence				.														.																		.
Template Conservation																																				.
Template Sequence		L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	K	G	A	Y	C	L	S	V	S	D	F	D	N	A	K	G	.	L	N	V	K	H	Y	K	I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S	L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H	R	L
Template Known Secondary structure		T		T	T			T	T								S	S	S	T	T											T	T	T		.									B		.			S						T	T				S	S													T	T	S	S	S
Template Predicted Secondary structure																																				.
Template SS confidence
		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.		.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	Y	P	V	G	L	M	G	S	C	L	P	A	T	A	G	F	S	Y	E	K	W	E	I	D	P	S	E	L	A	F	I	K	E	I	G	S	G	Q	F	G	V	V	H	L	G	E	W	R	S	H	I	Q	V	A	I	K	A	I	N	E	G	S	M	S	E	E	D	F	I	E	E	A	K	V	M	M	K	L	S
Query Conservation
Alig confidence										.	.	.
Template Conservation										.	.	.
Template Sequence		T	T	V	C	P	T	S	K	.	.	.	P	Q	T	Q	G	L	A	K	D	A	W	E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M	G	T	W	N	G	T	T	R	V	A	I	K	T	L	K	P	G	T	M	S	P	E	A	F	L	Q	E	A	Q	V	M	K	K	L	R
Template Known Secondary structure										.	.	.				S	S	S	S	T	T		S	B			G	G	G											S	S									T	T	T										T	T	S	S
Template Predicted Secondary structure										.	.	.
Template SS confidence
		242	.	.	.	.	.	.	.				250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.
		323	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.		.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.
Predicted Secondary structure																																						.
Query SS confidence																																						.
Query Sequence		H	S	K	L	V	Q	L	Y	G	V	C	I	Q	R	K	P	L	Y	I	V	T	E	F	M	E	N	G	C	L	L	N	Y	L	R	E	N	.	K	G	K	L	R	K	E	M	L	L	S	V	C	Q	D	I	C	E	G	M	E	Y	L	E	R	N	G	Y	I	H	R	D	L	A	A	R	N	C	L	V	S	S	T
Query Conservation																																						.
Alig confidence														.																								.
Template Conservation														.
Template Sequence		H	E	K	L	V	Q	L	Y	A	V	V	S	.	E	E	P	I	Y	I	V	T	E	Y	M	S	K	G	S	L	L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E	R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L	V	G	E	N
Template Known Secondary structure			T	T	B									.	S	S	S									T	T								S					T	T																							T	T				S			S	G	G	G					G	G
Template Predicted Secondary structure														.
Template SS confidence
		319	320	.	.	.	.	.	.	.	.	.	330		.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.
		402	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.
Predicted Secondary structure
Query SS confidence
Query Sequence		C	I	V	K	I	S	D	F	G	M	T	R	Y	V	L	D	D	E	Y	V	S	S	F	G	A	K	F	P	I	K	W	S	P	P	E	V	F	L	F	N	K	Y	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	V	F	T	E	G	K	M	P	F	E	N	K	S	N	L	Q	V	V	E	A	I	S	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	V	C	K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I	K	W	T	A	P	E	A	A	L	Y	G	R	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K	G	R	V	P	Y	P	G	M	V	N	R	E	V	L	D	Q	V	E	R
Template Known Secondary structure		G							T	T	S	T	T	T								T	T		S	T	T	S		G	G	G	S																											T	T	T	T			S	S	T	T												T
Template Predicted Secondary structure
Template SS confidence
		398	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.
		482	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	F	R	L	Y	R	P	H	L	A	P	M	S	I	Y	E	V	M	Y	S	C	W	H	E	K	P	E	G	R	P	T	F	A	E	L	L	R	A	V	T	E	I	A	E	T
Query Conservation
Alig confidence
Template Conservation
Template Sequence		G	Y	R	M	P	C	P	P	E	C	P	E	S	L	H	D	L	M	C	Q	C	W	R	K	E	P	E	E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y	F	T	S
Template Known Secondary structure		T							T	T													T		S	S	G	G	G	S												T	S	S
Template Predicted Secondary structure
Template SS confidence
		478	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.