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Job DescriptionP16885
Confidence100.00%DateSat Jun 16 10:20:27 BST 2012
Rank1Aligned Residues726
% Identity35%Templatec3ohmB_
PDB info PDB header:signaling protein / hydrolaseChain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3
Resolution2.70 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   12.......20.........30.........40.........50.........60.........70.........80.........90.
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Query Sequence  EYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK
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Template Sequence  QLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYW. TGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVL
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TT

S


TTS
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GGG
GGGTTTS



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   12.......20.........30.........40.........50.... .....60.........70.........80.........90
 
   92.......100.... .....110.........120.........130.........140.........150. ........160........
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Query Sequence  EDCCFTILYGTQF. VLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIY. . SVDQTRRNSISLRELKT
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Template Sequence  EEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASR. . NTFLRKAYTKLKLQVNQDGRIPVKNILK
Template Known Secondary structure 
TT
SSGGG
SSSS
T

..S

TTS
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   100.........110.........120.........130.........140......... 150.........160.........170.......
 
   169170.........180 .........190.. .......200.........210.........220.........230.........240......
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Query Sequence  ILPLINFKVSSA. KFLKDKFVEIGA. HKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF
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Template Sequence  MFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKL. . CLRPDIDKILLEIG. . . . . . . . . AKGKPYLTLEQL
Template Known Secondary structure  TTGGGTTT


STT

GGG

..S

TT.........

STT
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   178.180.........190.........200.........210.........220 .........230.... .....240......
 
   247..250.........260 .........270.........280.........290.........300.........310.........
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Query Sequence  QRFLIHEQQEHWAQ. . . . . . . DLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLS
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Template Sequence  MDFINQKQRDPRLNEVLYPPLRPSQARLLIEKY. EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDL. STDMTQPLS
Template Known Secondary structure  SS
TTS
TTTS



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TT
TSTTS
SS
SS.
S


S
GG
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   247..250.........260.........270......... 280.........290.........300.........310..... ....320....
 
   320.........330.........340.........350.........360... ......370.........380.........390.......
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Query Sequence  HYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDG. . PDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS
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Template Sequence  AYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTS
Template Known Secondary structure  G

BSSTTBSS
SS
B
STT




SSS



STTS

TTSS
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   325....330.........340.........350.........360.........370.........380.........390.........400....
 
   398.400......... 410.........420.........430...... ...440.........450.........460.........470..
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Query Sequence  SFPVILSIEEHC. SVEQQRHMAKAFKEVFGDLLLTKPTEA. . . . SADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKK
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Template Sequence  PYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHTDEGTASS. . . . .
Template Known Secondary structure 
S



TTGGGB

S
BTTB
SSSS




TTTTTT






TTGGGTT.....
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   405....410.........420.........430.........440.........450.........460.........470.........
 
   473......480.........490.........500.........510.........520.........530.........540.........550..
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Query Sequence  DEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCM
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Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   553......560.........570.........580.........590.........600.........610.........620.........630..
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Query Sequence  ETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLT
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   633......640.........650.........660.........670.........680.........690.........700.........710..
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Query Sequence  DPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFES
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   713......720.........730.........740.........750.........760.........770.........780.........790..
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Query Sequence  LVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCR
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   793......800.........810.........820.........830.........840.........850.........860.........870..
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Query Sequence  GALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSF
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   873......880.........890.........900.........910.........920.........930.........940..... ....950
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Query Sequence  VFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKD. . NLENP
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EVNATEEMSTLVNYIEPVKFKSFEAARKRN
Template Known Secondary structure  ..................................................




TT
SS





T
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   583......590.........600.........610..
 
   951........960.........970.........980.........990.........1000.........1010.........1020.........1030
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Query Sequence  DFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSL
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Template Sequence  KCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEY
Template Known Secondary structure 
TTSS


TT
TT




TTTT
S
B
TT

STT
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   613......620.........630.........640.........650.........660.........670.........680.........690..
 
   1031........1040...... ...1050......... 1060.........1070.........1080.........1090......... 1100......
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Query Sequence  NGRTGYVLQPESMRTE. . KYDPMPPESQRKI. LMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKF. KTTVVND
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Template Sequence  NGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRK. . . VGIYVEVDMFGLPVDTRRKYRTRTSQG
Template Known Secondary structure  GGG
S

GGGT
TT



TT
SS

TT


S

SS
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SSTTT
B







SS
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   693......700.........710.........720.........730.........740.. .......750.........760.........
 
   1107..1110......... 1120.. .......1130.........1140.........1150.........1160.........1170.........1180....
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Query Sequence  NGLSPIWAPTQEK. VTF. EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFC
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Template Sequence  NSFNPVW. . . DEEPFDFPKVVLPTLASLRIAAFEEG. . . . GKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYT
Template Known Secondary structure 
SSS
B
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S
GGG
TT....TTTT



TTS
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   770...... ...780.........790.........800.. .......810.........820.........830.........840..
 
   1185....1190... ......1200.........1210........
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Query Sequence  EMRPVLESE. . . . . EELYSSCRQLRRRQEELNNQLFLYD
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Template Conservation      

          
  
                   
Template Sequence  EASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIG
Template Known Secondary structure 


GGG
T
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   843......850.........860.........870.........880.
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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