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Job DescriptionP43403
Confidence100.00%DateThu Apr 26 09:45:10 BST 2012
Rank3Aligned Residues371
% Identity37%Templatec1oplA_
PDB info PDB header:transferaseChain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
Resolution3.42 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   159160.........170.........180.........190.. .......200.........210.........220.........230.......
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Query Sequence  ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPR. KEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVE
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Template Sequence  EKHSWYHGPVSRNAAEYLLSS. . GINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH
Template Known Secondary structure  GGSTT

GGG..

TT
SSSTT
TT

TTS
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BSS
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   142.......150.........160.. .......170.........180.........190.........200.........210.........
 
   238.240.........250.........260.........270.........280.........290.........300.........310.......
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Query Sequence  YLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYES
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Template Sequence  HHSTVADGLITTLHYPAPKRNKPTVYGVSPNY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  TT

TTSSS






S



SSS
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   220.........230.........240.........250.
 
   318.320.........330.........340.........350.........360.........370.........380.........390.......
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Query Sequence  PYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY
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Template Sequence  . . . . . . . . . . . DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYS. . LTVAVKTLKEDT. . MEVEEFLKEAAVMKEIKHPN
Template Known Secondary structure  ...........S

B

GGGSGGGTTSSGGGT..

SSS..S



TT
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   252.......260.........270.........280.... .....290...... ...300.........310......
 
   398.400..... ....410.........420.........430. ........440.........450.........460.........470.....
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Query Sequence  IVRLIGVC. QAEALMLVMEMAGGGPLHKFLVGKRE. EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA
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Template Sequence  LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLV
Template Known Secondary structure  B


SSSS


TT
BS
TTTS
TT
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SGGG
GGG
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   317..320.........330.........340.........350.........360.........370.........380.........390......
 
   476...480.........490.........500.........510.........520.........530.........540.........550.....
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Query Sequence  KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG
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Template Sequence  KVADFGLSRLMTGDT. . YTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD
Template Known Secondary structure 

TT


TT

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   397..400.........410. ........420.........430.........440.........450.........460.........470....
 
   556...560.........570.........580.........590......
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Query Sequence  KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC
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Template Sequence  YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM
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TT

T
SSGGGS

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   475....480.........490.........500.........510.....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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