Email l.a.kelley@imperial.ac.uk Description Q6XZF7 Date Thu Apr 26 09:30:42 BST 2012 Unique Job ID 56338b38252c9db8

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2dx1A_ 100.0 39 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4; PDBTitle: crystal structure of rhogef protein asef 2 c1griA_ 100.0 23 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 3 c3ky9B_ 100.0 25 PDB header:apoptosis Chain: B: PDB Molecule:proto-oncogene vav; PDBTitle: autoinhibited vav1 4 c1ng2A_ 99.9 27 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosolic factor 1; PDBTitle: structure of autoinhibited p47phox 5 c2l3sA_ 99.9 24 PDB header:structural protein Chain: A: PDB Molecule:autoinhibited crk protein; PDBTitle: structure of the autoinhibited crk 6 c1ov3A_ 99.9 27 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosol factor 1; PDBTitle: structure of the p22phox-p47phox complex 7 c2eyzA_ 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 8 c2vrwB_ 99.9 26 PDB header:signaling protein Chain: B: PDB Molecule:proto-oncogene vav; PDBTitle: critical structural role for the ph and c1 domains of the2 vav1 exchange factor 9 c3ksyA_ 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:son of sevenless homolog 1; PDBTitle: crystal structure of the histone domain, dh-ph unit, and2 catalytic unit of the ras activator son of sevenless (sos) 10 c3odoA_ 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1; PDBTitle: crystal structure of the dh/ph domains of p115-rhogef 11 c1xcgA_ 99.9 20 PDB header:signaling protein activator/signaling pr Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 11; PDBTitle: crystal structure of human rhoa in complex with dh/ph2 fragment of pdzrhogef 12 c1foeA_ 99.9 29 PDB header:signaling protein, immune system/signali Chain: A: PDB Molecule:t-lymphoma invasion and metastasis inducing PDBTitle: crystal structure of rac1 in complex with the guanine2 nucleotide exchange region of tiam1 13 c1x86A_ 99.9 19 PDB header:signaling protein/membrane protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12; PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa 14 c3t06E_ 99.9 20 PDB header:signaling protein Chain: E: PDB Molecule:rho guanine nucleotide exchange factor 11; PDBTitle: crystal structure of the dh/ph fragment of pdzrhogef with n-terminal2 regulatory elements in complex with human rhoa 15 d1xcga1 99.9 20 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 16 c2dfkA_ 99.9 29 PDB header:cell cycle Chain: A: PDB Molecule:collybistin ii; PDBTitle: crystal structure of the cdc42-collybistin ii complex 17 c3bjiA_ 99.9 25 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1 18 c1xdvB_ 99.9 20 PDB header:signaling protein Chain: B: PDB Molecule:son of sevenless protein homolog 1; PDBTitle: experimentally phased structure of human the son of2 sevenless protein at 4.1 ang. 19 d1txda1 99.9 20 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 20 c2z0qA_ 99.9 32 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 3; PDBTitle: crystal structure of dh-ph domain of rhogef3(xpln) 21 c1ki1B_ not modelled 99.9 26 PDB header:signaling protein Chain: B: PDB Molecule:intersectin long form; PDBTitle: guanine nucleotide exchange region of intersectin in2 complex with cdc42 22 d1dbha1 not modelled 99.9 20 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 23 c1lb1C_ not modelled 99.9 29 PDB header:signaling protein Chain: C: PDB Molecule:guanine nucleotide exchange factor dbs; PDBTitle: crystal structure of the dbl and pleckstrin homology2 domains of dbs in complex with rhoa 24 d2dfka1 not modelled 99.9 31 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 25 c2rgnB_ not modelled 99.9 26 PDB header:signaling protein complex Chain: B: PDB Molecule:rhoa/rac/cdc42 exchange factor; PDBTitle: crystal structure of p63rhogef complex with galpha-q and rhoa 26 c3odwB_ not modelled 99.9 22 PDB header:signaling protein Chain: B: PDB Molecule:rho guanine nucleotide exchange factor 1; PDBTitle: crystal structure of the linker-dh/ph domains of p115-rhogef 27 c1dbhA_ not modelled 99.9 19 PDB header:gene regulation Chain: A: PDB Molecule:protein (human sos 1); PDBTitle: dbl and pleckstrin homology domains from hsos1 28 d1foea1 not modelled 99.9 32 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 29 c3odxA_ not modelled 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 1; PDBTitle: crystal structure of an n-terminally truncated linker-dh/ph domains of2 p115-rhogef 30 d1ki1b1 not modelled 99.9 25 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 31 d1by1a_ not modelled 99.9 24 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 32 c3mpxA_ not modelled 99.9 17 PDB header:lipid binding protein Chain: A: PDB Molecule:fyve, rhogef and ph domain-containing protein 5; PDBTitle: crystal structure of the dh and ph-1 domains of human fgd5 33 d1kz7a1 not modelled 99.9 27 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 34 c3eo2A_ not modelled 99.8 31 PDB header:splicing Chain: A: PDB Molecule:neuroepithelial cell-transforming gene 1 protein; PDBTitle: crystal structure of the rhogef domain of human neuroepithelial cell-2 transforming gene 1 protein 35 c1ntyA_ not modelled 99.8 25 PDB header:signaling protein Chain: A: PDB Molecule:triple functional domain protein; PDBTitle: crystal structure of the first dh/ph domain of trio to 1.7 a 36 d1ntya1 not modelled 99.8 25 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 37 d1f5xa_ not modelled 99.8 25 Fold:DBL homology domain (DH-domain) Superfamily:DBL homology domain (DH-domain) Family:DBL homology domain (DH-domain) 38 c1mv3A_ 99.8 7 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc 39 c3gf9A_ not modelled 99.8 29 PDB header:endocytosis Chain: A: PDB Molecule:intersectin 2; PDBTitle: crystal structure of human intersectin 2 rhogef domain 40 c2dybA_ not modelled 99.7 31 PDB header:oxidoreductase Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: the crystal structure of human p40(phox) 41 c2ficA_ 99.7 22 PDB header:endocytosis/exocytosis, membrane protein Chain: A: PDB Molecule:bridging integrator 1; PDBTitle: the crystal structure of the bar domain from human bin1/amphiphysin ii2 and its implications for molecular recognition 42 d1ng2a2 99.6 20 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 43 c2e5kA_ 99.6 17 PDB header:protein binding Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1; PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1 44 c2rqrA_ 99.6 19 PDB header:protein binding Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex 45 d1uhca_ 99.6 94 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 46 d1udla_ not modelled 99.6 23 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 47 d1ug1a_ not modelled 99.6 20 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 48 c2jxbA_ not modelled 99.6 19 PDB header:signaling protein complex Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain, PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex 49 d1ov3a2 not modelled 99.6 20 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 50 c2dlpA_ not modelled 99.6 18 PDB header:structural protein Chain: A: PDB Molecule:kiaa1783 protein; PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein 51 c2jmcA_ not modelled 99.6 17 PDB header:signaling protein Chain: A: PDB Molecule:spectrin alpha chain, brain and p41 peptide PDBTitle: chimer between spc-sh3 and p41 52 c1x6gA_ not modelled 99.6 17 PDB header:signaling protein Chain: A: PDB Molecule:megakaryocyte-associated tyrosine-protein kinase; PDBTitle: solution structures of the sh3 domain of human2 megakaryocyte-associated tyrosine-protein kinase. 53 c2csqA_ not modelled 99.5 21 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:rim binding protein 2; PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2 54 c3nmzD_ not modelled 99.5 15 PDB header:cell adhesion/cell cycle Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4; PDBTitle: crytal structure of apc complexed with asef 55 d1i1ja_ not modelled 99.5 18 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 56 c3sogA_ 99.5 24 PDB header:structural protein Chain: A: PDB Molecule:amphiphysin; PDBTitle: crystal structure of the bar domain of human amphiphysin, isoform 1 57 c1x43A_ not modelled 99.5 26 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:sh3 domain grb2-like protein b1; PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1) 58 d1urua_ 99.5 23 Fold:BAR/IMD domain-like Superfamily:BAR/IMD domain-like Family:BAR domain 59 c1uruA_ 99.5 23 PDB header:endocytosis Chain: A: PDB Molecule:amphiphysin; PDBTitle: amphiphysin bar domain from drosophila 60 c2cubA_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1 61 c2egeA_ not modelled 99.5 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein kiaa1666; PDBTitle: solution structure of the third sh3 domain from human2 kiaa1666 protein 62 c2yuoA_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:run and tbc1 domain containing 3; PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3 63 c1x2qA_ not modelled 99.5 23 PDB header:signaling protein Chain: A: PDB Molecule:signal transducing adapter molecule 2; PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2 64 c2ysqA_ not modelled 99.5 23 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9; PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9 65 c2dl7A_ not modelled 99.5 24 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa0769 protein; PDBTitle: solution structure of the second sh3 domain of human2 kiaa0769 protein 66 d1wlpb2 not modelled 99.5 18 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 67 c1zlmA_ not modelled 99.5 36 PDB header:signaling protein Chain: A: PDB Molecule:osteoclast stimulating factor 1; PDBTitle: crystal structure of the sh3 domain of human osteoclast2 stimulating factor 68 c2ekhA_ not modelled 99.5 24 PDB header:signaling protein Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a; PDBTitle: solution structures of the sh3 domain of human kiaa0418 69 d1bb9a_ not modelled 99.5 17 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 70 c1bb9A_ not modelled 99.5 17 PDB header:transferase Chain: A: PDB Molecule:amphiphysin 2; PDBTitle: crystal structure of the sh3 domain from rat amphiphysin 2 71 d1uuea_ not modelled 99.5 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 72 d2v1ra1 not modelled 99.5 33 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 73 d1ycsb2 not modelled 99.5 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 74 c2yt6A_ not modelled 99.5 26 PDB header:cell cycle Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full- PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1 75 c2eyyA_ not modelled 99.5 20 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 76 c2djqA_ not modelled 99.5 31 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sh3 domain containing ring finger 2; PDBTitle: the solution structure of the first sh3 domain of mouse sh32 domain containing ring finger 2 77 c1x2pA_ not modelled 99.5 30 PDB header:transferase Chain: A: PDB Molecule:protein arginine n-methyltransferase 2; PDBTitle: solution structure of the sh3 domain of the protein2 arginine n-methyltransferase 2 78 d1jqqa_ not modelled 99.5 26 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 79 c2oi3A_ not modelled 99.5 21 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1) 80 c2epdA_ not modelled 99.5 30 PDB header:protein binding Chain: A: PDB Molecule:rho gtpase-activating protein 4; PDBTitle: solution structure of sh3 domain in rho-gtpase-activating2 protein 4 81 c2ed1A_ not modelled 99.5 30 PDB header:signaling protein Chain: A: PDB Molecule:130 kda phosphatidylinositol 4,5-biphosphate- PDBTitle: solution structure of the sh3 domain of 130 kda2 phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase-3 activating protein 82 c1wyxA_ not modelled 99.5 32 PDB header:cell adhesion Chain: A: PDB Molecule:crk-associated substrate; PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution 83 d1ujya_ not modelled 99.5 30 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 84 c1x69A_ not modelled 99.5 24 PDB header:signaling protein Chain: A: PDB Molecule:cortactin isoform a; PDBTitle: solution structures of the sh3 domain of human src2 substrate cortactin 85 c2csiA_ not modelled 99.5 28 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:rim binding protein 2; PDBTitle: solution structure of the third sh3 domain of human rim-2 binding protein 2 86 c2pqhA_ not modelled 99.5 23 PDB header:structural protein Chain: A: PDB Molecule:spectrin alpha chain, brain; PDBTitle: structure of sh3 chimera with a type ii ligand linked to the chain c-2 terminal 87 d1k4us_ not modelled 99.5 41 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 88 c2dnuA_ not modelled 99.5 21 PDB header:structural genomics, structural protein Chain: A: PDB Molecule:sh3 multiple domains 1; PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human 89 c2yupA_ not modelled 99.5 23 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the second sh3 domain of human vinexin 90 c2d1xD_ not modelled 99.5 25 PDB header:cell invasion Chain: D: PDB Molecule:cortactin isoform a; PDBTitle: the crystal structure of the cortactin-sh3 domain and amap1-2 peptide complex 91 c2dilA_ not modelled 99.5 29 PDB header:cell adhesion Chain: A: PDB Molecule:proline-serine-threonine phosphatase-interacting PDBTitle: solution structure of the sh3 domain of the human proline-2 serine-threonine phosphatase-interacting protein 1 92 c3rnjA_ not modelled 99.5 21 PDB header:protein binding Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein PDBTitle: crystal structure of the sh3 domain from irsp53 (baiap2) 93 c2bz8B_ not modelled 99.5 24 PDB header:sh3 domain Chain: B: PDB Molecule:sh3-domain kinase binding protein 1; PDBTitle: n-terminal sh3 domain of cin85 bound to cbl-b peptide 94 c2dl4A_ not modelled 99.5 37 PDB header:signaling protein Chain: A: PDB Molecule:protein stac; PDBTitle: solution structure of the first sh3 domain of stac protein 95 c2ebpA_ not modelled 99.5 12 PDB header:cell adhesion Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1; PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1 96 d1u06a1 not modelled 99.5 31 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 97 c2cudA_ not modelled 99.5 16 PDB header:signaling protein Chain: A: PDB Molecule:src-like-adapter; PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap) 98 c2dbmA_ not modelled 99.5 36 PDB header:transferase, signaling protein Chain: A: PDB Molecule:sh3-containing grb2-like protein 2; PDBTitle: solution structures of the sh3 domain of human sh3-2 containing grb2-like protein 2 99 c2kbtA_ not modelled 99.5 36 PDB header:signaling protein Chain: A: PDB Molecule:chimera of proto-oncogene vav, linker, PDBTitle: attachment of an nmr-invisible solubility enhancement tag2 (inset) using a sortase-mediated protein ligation method 100 c2creA_ not modelled 99.5 26 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hef-like protein; PDBTitle: solution structure of rsgi ruh-036, an sh3 domain from2 human cdna 101 d1e6ga_ not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 102 c2fpeB_ not modelled 99.5 23 PDB header:signaling protein Chain: B: PDB Molecule:c-jun-amino-terminal kinase interacting protein PDBTitle: conserved dimerization of the ib1 src-homology 3 domain 103 d1gria2 not modelled 99.5 21 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 104 d1oeba_ not modelled 99.5 26 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 105 c2dmoA_ not modelled 99.5 31 PDB header:signaling protein Chain: A: PDB Molecule:neutrophil cytosol factor 2; PDBTitle: refined solution structure of the 1st sh3 domain from human2 neutrophil cytosol factor 2 (ncf-2) 106 c2egcA_ not modelled 99.5 26 PDB header:signaling protein Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a; PDBTitle: solution structure of the fifth sh3 domain from human2 kiaa0418 protein 107 d1e6ha_ not modelled 99.5 28 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 108 d1uffa_ not modelled 99.5 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 109 d1utia_ not modelled 99.5 27 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 110 c1wx6A_ not modelled 99.5 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:cytoplasmic protein nck2; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck2 111 c1wi7A_ not modelled 99.5 39 PDB header:protein binding Chain: A: PDB Molecule:sh3-domain kinase binding protein 1; PDBTitle: solution structure of the sh3 domain of sh3-domain kinase2 binding protein 1 112 c2yunA_ not modelled 99.5 26 PDB header:protein transport Chain: A: PDB Molecule:nostrin; PDBTitle: solution structure of the sh3 domain of human nostrin 113 c2nwmA_ not modelled 99.5 35 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin 114 d1uj0a_ not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 115 c2df6A_ not modelled 99.5 40 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7; PDBTitle: crystal structure of the sh3 domain of betapix in complex2 with a high affinity peptide from pak2 116 d1oota_ not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 117 c2dl3A_ not modelled 99.5 35 PDB header:cell adhesion, signaling protein Chain: A: PDB Molecule:sorbin and sh3 domain-containing protein 1; PDBTitle: solution structure of the first sh3 domain of human sorbin2 and sh3 domain-containing protein 1 118 c2ed0A_ not modelled 99.5 35 PDB header:signaling protein Chain: A: PDB Molecule:abl interactor 2; PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2) 119 d1wiea_ not modelled 99.5 24 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 120 c2js0A_ not modelled 99.5 27 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: solution structure of second sh3 domain of adaptor nck