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Job DescriptionP43405
Confidence100.00%DateFri May 25 09:37:32 BST 2012
Rank155Aligned Residues237
% Identity39%Templatec3k54A_
PDB info PDB header:transferaseChain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: structures of human bruton's tyrosine kinase in active and inactive2 conformations suggests a mechanism of activation for tec family3 kinases.
Resolution1.94 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   360.........370.........380.........390.........400.........410.........420.........430.........
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Query Sequence  PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC
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Template Sequence  YGSWEIDPKDLTFLK. ELGTGQFGVVKYGKW. . . RGQYDVAIKMIK. . . . . . . . . . EFIEEAKVMMNLSHEKLVQLYGVC
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   392.......400...... ...410.........420. ........430... ......440.........450.......
 
   440.........450.........460 .........470.........480.........490.........500.........510.......
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Query Sequence  . EAESWMLVMEMAELGPLNKYL. QQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK
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Template Sequence  TKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGFP.
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   465....470.........480.........490.........500.........510.........520.........530.........540...
 
   518.520.........530.........540.........550.........560.........570.........580.........590.......
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Query Sequence  ALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC
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Template Sequence  . . . . . . . . . . . . . . . . . . VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLA
Template Known Secondary structure  ..................GGG





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   561........570.........580.........590.........600.........610.........620..
 
   598.600.........610.........620.........
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Query Sequence  PREMYDLMNLCWTYDVENRPGFAAVELRLRNY
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Template Sequence  SEKVYTIMYSCWHEKADERPTFKILLSNILDV
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   623......630.........640.........650....
 
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No model constructed - rank, confidence too low




Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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