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Job DescriptionP43405
Confidence100.00%DateFri May 25 09:37:32 BST 2012
Rank74Aligned Residues254
% Identity28%Templatec3d4qA_
PDB info PDB header:transferaseChain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase; PDBTitle: pyrazole-based inhibitors of b-raf kinase
Resolution2.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   361........370.........380.........390.........400.........410.........420.........430.........440
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Query Sequence  KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE
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Template Sequence  DDWEIPDGQITV. GQRIGSGSFGTVYKGKWHGD. . . . . VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYST
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B

TT

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SSS

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TTB


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   448.450......... 460.........470......... 480.........490.........500.........510.........520.
 
   441........450.........460..... ....470.........480.........490.........500.........510.........
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Query Sequence  AESWMLVMEMAELGPLNKYLQQNRH. VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL
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Template Sequence  KPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVL
Template Known Secondary structure  SSS


SS
BTS




TT
B
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SGGGTTT


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   522.......530.........540.........550.........560.........570.........580.........590.........600.
 
   520.........530.........540........ .550.........560.........570.........580 .........590..
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Query Sequence  RADENYYKAQTHGKWPVKWYAPECINYYK. . . FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE. VTAMLEKGERMG. . .
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Template Sequence  . . . . . . . . . . . . . SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT. GQLPYSNINNRDQIIFMVGRGYLSPDLS
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   614.....620.........630.........640.........650. ........660.........670.........
 
   593......600.........610.........620.........630....
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Query Sequence  . CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV
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Template Sequence  KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
Template Known Secondary structure  GS
TTS
T
SSGGGS

T

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   680.........690.........700.........710.........720..
 
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No model constructed - rank, confidence too low




Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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