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Job DescriptionP43405
Confidence100.00%DateFri May 25 09:37:32 BST 2012
Rank5Aligned Residues372
% Identity40%Templatec2h8hA_
PDB info PDB header:transferaseChain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor
Resolution2.20 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   164.....170.........180.........190....... ..200......... 210.........220.........230.......
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Query Sequence  EKMPWFHGKISREESEQIVLIGSKTNGKFLIRAR. DNNGSYALCLLH. . . . . EGKVLHYRIDKDKTGKLSIPEGKKFDTL
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Template Sequence  QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSL
Template Known Secondary structure  GGSTTB

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   144.....150.........160.........170.........180.........190.........200.........210.........220...
 
   238.240.........250.........260.........270.........280.........290.........300.........310.......
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Query Sequence  WQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQEST
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Template Sequence  QQLVAYYSKHADGLCHRLTTVCP. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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TTSSS




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   224.....230.........240......
 
   318.320.........330.........340.........350.........360.........370.........380.........390.......
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Query Sequence  VSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVK
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . TSKPQTQGLAKDAWEIPRESLRL. . . . . . . . EVKLGQGCFGEVWMGTWN. . . GTT
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SSSSTT
SB

GGG........
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   247..250.........260......... 270.........280....... ..290
 
   398.400.........410.........420.........430.........440.........450.........460 .........470.....
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Query Sequence  TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL. . QQNRHVKDKNIIELV
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Template Sequence  RVAIKTLKPGTMS. . . PEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA
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   291........300... ......310.........320.........330.........340.........350.........360.......
 
   476...480.........490.........500.........510.........520.........530.........540.........550.....
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Query Sequence  HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDV
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Template Sequence  AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI. . EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV
Template Known Secondary structure  TT


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   368.370.........380.........390.........400.........410. ........420.........430.........440.....
 
   556...560.........570.........580.........590.........600.........610.........620.........630...
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Query Sequence  WSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV
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Template Sequence  WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST
Template Known Secondary structure  TTTT

SSTT

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   446...450.........460.........470.........480.........490.........500.........510.........520...
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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